Digital Commons Network^™

Influence Of Exercise Training On Nitric Oxide Pathways And Their Physiological Effects, Jonas Benjamim, Stephen J Bailey, Leonardo Da Silva Gonçalves, Mia Burleigh, Mario Siervo, Andrew R Coggan, Raúl Bescos

School of Health Professions

Nitric oxide (NO) is a critical signalling molecule in cardiovascular, metabolic, and muscular function. Endogenous NO production occurs via two primary metabolic pathways: 1) the classical nitric oxide synthases (NOS) pathway, and 2) the alternative (nitrate-nitrite-NO) pathway, in which inorganic nitrate (NO 3 -) is sequentially reduced to nitrite (NO 2 -) and other NO intermediates (e.g., S-nitrosothiol). The latter pathway relies heavily on the oral microbiota, which catalyze the two-electron partial reduction of NO 3 - to NO 2 -, which is influenced by oral physiology, microbial composition and salivary flow. While the role of exercise training in enhancing …

Nature-Based And Outdoor Learning In The K-12 Setting, Samantha Bertotti, Cecilia Dunbar, Julia Fazio

Psychology and Child Development

This literature review examines the impact of nature-based and outdoor learning on K–12 students’ academic achievement, socio-emotional development, and mental health. Drawing on a wide range of empirical studies and systematic reviews, the paper highlights how learning in natural environments enhances academic outcomes by improving self-efficacy, cognitive functioning, and student engagement. Evidence consistently shows that outdoor learning fosters critical thinking, collaboration, and deeper conceptual understanding compared to traditional classroom instruction.

In addition to academic benefits, nature-based learning supports socio-emotional development by strengthening peer relationships, promoting confidence, and encouraging prosocial behaviors such as cooperation and empathy. These environments provide opportunities for …

Design And Tissue Engineering Applications Of Microporous Annealed Particle (Map) Scaffolds, Nic D. Leipzig, Oluwaseyi Shofolawe-Bakare

University Research

Microporous annealed particle (MAP) scaffolds are emerging as a facile, yet sophisticated biomaterial platform with tremendous potential for tissue regenerative applications. These scaffolds are fabricated in situ through interparticle crosslinking of microgels using a variety of covalent or non-covalent techniques and possess excellent tunability and biocompatibility. The microporous structure of MAP scaffolds allows cellular infiltration and vascularization independent of degradation rate, making them more advantageous than traditional nanoporous bulk hydrogels. Moreover, the incorporation of in situ crosslinking allows MAP scaffolds to retain the key advantages of traditional microgel-based scaffolds—such as injectability and modularity—while providing the added benefit of a fixed …

Improving Vaccination In People With Ckd: Report From A National Kidney Foundation Working Group, Susan F. Massengill, Kenneth A. Andreoni, Keith A. Bellovich, Cheryl Courtlandt, Vimal K. Derebail, David L. Feldman, Gia J. Oh, John W. Sleasman, Kristina A. Bryant, Improving Vaccination In Ckd Working Group

Department of Surgery Faculty Papers

People with chronic kidney disease (CKD) are particularly vulnerable to vaccine-preventable infections. Therefore, the National Kidney Foundation organized a multidisciplinary working group, including people with CKD and family care partners, to develop recommendations to improve vaccination rates, vaccination effectiveness, and health care for the CKD population. A modified Delphi process was used to achieve consensus on the recommendations. Recommendations on vaccination in CKD patients were organized into these categories: (1) patient preferences; (2) assessing the vaccination status of patients with CKD; (3) assessing vaccine response in patients with CKD; (4) vaccination of immunocompromised patients; (5) vaccination in posttransplant patients; (6) …

The Social And Biological Frontiers Of Polio: Comparing Global Eradication Strategies, Srisai A. Turangi

Honors Program: Senior Projects (Public)

This paper provides a comparative analysis of the divergent global strategies for poliomyelitis (polio) eradication, examining the historical and structural contexts of developed nations – the United States and United Kingdom – alongside the enduring challenges in endemic regions such as Nigeria and Pakistan. Biomedical innovations like the Inactivated Polio Vaccine (IPV) and Oral Polio Vaccine (OPV) have helped bring the world to a state of almost complete global eradication, but progress is still uneven due to variations in funding, healthcare infrastructure, and the legacy of colonialism. Studies reveal how a framework where global health inequalities remained, allowed for resource-rich …

Effect Of Dynamic Fatigue Loading On The Adaptation And Retention Of Maxillary Single Dentures Reinforced With Digitally Constructed Zirconia And Cobalt–Chromium Frameworks, Ghada Elgindy, Fardos N Rizk, Marwa Ezzat Sabet, Hebatallah Tarek Mohamed

Dentistry

Background. The impact of dynamic fatigue loading on denture adaptation and retention is clinically important. Zirconia and cobalt–chromium (Co–Cr) frameworks enhance denture strength, but their performance under cyclic loading remains unclear. Objectives. The aim of the study was to evaluate the adaptation and retention of maxillary single dentures reinforced with digitally constructed Co–Cr or zirconia frameworks after a simulated 1 year of function. Material and methods. Three types of maxillary single dentures were constructed on maxillary master casts. Group A included maxillary dentures without reinforcement (control group), whereas groups B and C encompassed maxillary dentures reinforced with digitally designed and …

Evaluation Of Publicly Available Maize Germplasm Adaptation To Environments In Nebraska, Garrett Snodgrass

Department of Agronomy and Horticulture: Dissertations, Theses, and Student Research

Publicly available maize germplasm represents an important resource for breeding programs seeking to expand genetic diversity and improve hybrid performance. However, effective use requires characterization of per se phenotypic performance of parental lines and evaluation of the parental line’s hybrid progeny adaptation to a given target population of environments. Furthermore, understanding population structure and heterotic grouping is imperative for maximizing efficiency of breeding decisions. The objectives of this study were to (1) evaluate phenotypic performance of parental lines and hybrids across environments in Nebraska, and to (2) refine heterotic group classification of parental lines within the University of Nebraska-Lincoln’s Hybrid …

From Surplus To Sustenance: Confronting Food Waste To Uphold The Right To Food, Emily M. Broad Leib, Noelle Musolino

Vanderbilt Journal of Transnational Law

No abstract provided.

Identification Of Microplastics And Additives From The Lake Erie Watershed And The Cuyahoga River Via Maldi-Ms And Dart-Ms, Chrys Wesdemiotis, Calum Bochenek, Luciana Rivera Molina, Robert Brand

University Research

Micro(nano)plastics have received increased attention as environmental contaminants due to their harmful effects on ecosystems and human health. Conventional extraction methods for microplastic analysis are often lengthy and complicated, resulting in the loss of important chemical components such as additives. In this study, we provide a complementary approach, utilizing matrix-assisted laser desorption/ionization (MALDI) and direct analysis in real time (DART) mass spectrometry (MS) techniques, with minimal extraction and sample preparation to preserve both polymer and additive information. MALDI-MS was applied to aqueous samples collected along the shores of Lake Erie and the Cuyahoga River, successfully identifying the base polymer(s) in …

Improving Equity Within The Holistic Admission Process Through Race-Neutral Holistic Review: A Before And After Cross-Sectional Study, Megan Eikenberry, Kylie Scott, Jaime González, Josh Subialka, Lacey Frankland, Patrice Ayala, Mark Kargela, Byron Russell

Physical Therapy Faculty Publications

Introduction: The US Physical therapist (PT) workforce lacks racial and ethnic diversity, which may contribute to health disparities. Holistic review (HR) admission methods may improve workforce diversity by evaluating applicants' academic metrics, experiences, and personal attributes. Holistic review processes must adapt following the 2023 Supreme Court ruling prohibiting race-based admission criteria.

Review of literature: Holistic review criteria are program-specific and align with institutional and programmatic goals. While HR is shown to improve student body diversity, most PT education programs heavily emphasize academic metrics, which may disadvantage racial and ethnic minority (REM) applicants from acceptance. This study examines the racial and …

Asset: Scaling Authentic Science Education, Alexandra Forgerson, Carol Colaninno, Rachel Ruggirello, Doug Chalker

Institute for School Partnership: Research & Publications

The Washington University in St. Louis (WashU) Advancing Secondary Science Education through Tetrahymena (ASSET) program is a long-standing science education program that was initially developed at Cornell University and transferred to WashU in 2023. Funded through the National Institutes of Health (NIH) Science Education Partnership Award (SEPA), the ASSET program enhances STEM education by providing research-based, inquiry-driven learning experiences for K-12 students. The program integrates phenomenon-based storylines aligned with the Next Generation Science Standards (NGSS) to promote critical thinking and engagement among students. All ASSET learning experiences feature a living model organism, Tetrahymena, a single-celled protozoan that is safe and …

Dna Barcoding And Metabarcoding Reveal Labeling Accuracy And Species Substitution In Squid And Surimi From Los Angeles Markets, Demian A. Willette, Margarita L. Joaquin

Biology Faculty Works

Accurate species identification of seafood remains a persistent challenge in local and global marketplaces. This is particularly true for processed products that obscure diagnostic features. Here, we conduct a dual-molecular investigation into frozen squid and imitation crab products sold at American, Asian, and Hispanic grocery stores in Los Angeles, California, to assess label integrity under current U.S. Food & Drug Administration (FDA) guidance. Forty-eight squid samples from 13 retailers underwent DNA barcoding and yielded high percentage matches to 10 species across six genera. Despite broad labeling as ‘squid’, all samples matched FDA Acceptable Market Names with a 0 % mislabeling …

Situation Mouse All Floxed Up: Exploring Phenotypic Abnormalities In Bdnf Floxed Mice, Marissa A. Burkman

All NMU Master's Theses

Animal research is a contentious topic in both the scientific and general communities.  It is essential that our animal models accurately and predictably depict intended phenotypes, necessitating careful colony monitoring and maintenance.  Volunteer animal staff in the Ottem Laboratory became concerned when mice with LoxP sites flanking the BDNF gene depicted anxiety-like behaviors such as aggression, difficulty handling, and increased agitation.  Though many studies have noted behavioral and phenotypic abnormalities related to large gene inserts, few have noted abnormalities with small gene inserts such as the 34 bp LoxP site.  Brandt (2018) performed a three-stage behavioral protocol on these mice …

Time-Dependent Amplification Of Growth Rates In A Plankton-Oxygen Model, Rapha Coutin

Master's Theses

Near-bottom hypoxia occurs when dissolved oxygen levels drop to a level that is harmful to marine biology, creating biological dead zones along the ocean floor. Recent years have seen a dramatic increase in the percentage of coastal, near-bottom, hypoxic water, with the average in 2021 nearly double that of the average from 2009 to 2018 and about twenty-eight times the average from 1950 to 1980. Recent literature has linked this increase in oceanic hypoxia to the increase in upwelling-favorable winds caused by climate change. Upwelling brings low-oxygen, nutrient-rich water up to the surface, leading to plankton blooms and mass consumption …

Toxic Immortality: Rethinking Decline And Plastics With Lucretius, Jessica Croteau

Environmental Studies Faculty Scholarship

Much of contemporary environmental thought operates within paradigms of conservation, sustainability, and resilience—frameworks that assume the goal of ecological politics must be to prevent loss, preserve stability, and mitigate decline. However, these frameworks inadequately address cases where persistence and abundance, rather than disappearance, are the source of harm. By contrast, this article argues that an ecological ethic oriented toward decline, unbecoming, and decomposition reveals an alternative set of political and material stakes: not the conservation of things but their proper dissolution. Drawing from the materialist philosophy of Lucretius, the article critiques the prevailing assumption that endurance is inherently beneficial, highlighting …

Model For Analyzing Floorplate Morphology That Optimizes Daylighting And Cost, Andrew G. Welch, Ermal Shpuza Phd

The Kennesaw Journal of Undergraduate Research

One key method to improve the energy efficiency of a building is to enhance daylight levels, which reduces the need for artificial lighting. Elevated daylight levels are also associated with increased productivity and well-being of building occupants. Daylight levels are inversely proportional to the building compactness, where shallow floorplates and elongated buildings are associated with higher daylight levels. However, creating buildings that have more natural light comes with a greater construction cost due to larger envelope areas as well as greater operating costs due to the energy loss through the exterior envelope area. This research identifies the basic design strategies …

E3 Ubiquitin Ligases And Asthma Relief, Ajay P. Nayak

Department of Medicine Faculty Papers

No abstract provided.

After Grants Pass: The Case For Recentering The Criminal Legal System And Its Constitutional Constraints, Scout Katovich

William & Mary Law Review

In City of Grants Pass v. Johnson, the Supreme Court held that the Eighth Amendment does not prohibit cities from punishing unhoused people for sleeping outside when they have nowhere else to go. While the holding was legally narrow, the Court’s rhetoric framed criminalization as sound policy rather than punishment, obscuring the criminal legal system implications at the heart of the case. Cities responded not to the narrow holding but to the rhetorical message: In the year following the decision, they enacted hundreds of new laws criminalizing homelessness and dramatically intensified enforcement.

This Article argues for the recentering of …

The New Necessity, Ezra Rosser

William & Mary Law Review

According to the U.S. Supreme Court, cities are free to criminalize homelessness. The 2024 case City of Grants Pass v. Johnson is the most important homelessness case in decades and was a significant blow to advocates for the unhoused. The conservative majority rejected the idea that city ordinances criminalizing sleeping in public amounted to cruel and unusual punishment insofar as they penalized status. There is no sidestepping the loss. But within the faint glow of the embers of the oral argument and of the decision itself, there is the possibility that a new understanding of necessity, supported by the same …

Family Nurse Practitioner Workforce Response To The Public Health Opioid Crisis Through Curriculum Revision, Dayle Sharp, Marcy Doyle, Michelle Capozzoli

All Materials

The opioid crisis continues to pose a critical public health challenge in the United States, demanding an adequately trained primary care workforce. In response, a Family Nurse Practitioner (FNP) program revised its curriculum to prepare students to care for individuals with Opioid Use Disorder (OUD) through a multi-pronged educational intervention. Grounded in Social Cognitive Theory, Situated Learning Theory, and Community of Practice Theory, the revised curriculum integrated a 24-hour Medication for Opioid Use Disorder (MOUD) waiver training, clinical shadowing with MOUD providers, and participation in a 10-month Project ECHO telementoring series based on SAMHSA’s Treatment Improvement Protocol (TIP) 63. Results …

Apoe And Plasma Ad Biomarkers: The Role Of Genetic Ancestry In Hispanics/Latinos, Caitlin Cheung, Natasha Z Anita, Paola Filigrana, Myriam Fornage, Kevin A Gonzalez, Linda C Gallo, Carmen R Isasi, Robert C Kaplan, Xihao Li, Freddie Márquez, Humberto Parada, Krista M Perreira, Alberto R Ramos, Tatjana Rundek, Wassim Tarraf, Fernando D Testai, Charles Decarli, Hector M González, Tamar Sofer

Faculty, Staff and Student Publications

Background: Apolipoprotein E (APOE) alleles are well-established genetic risk factors for Alzheimer's disease (AD), but their effects on AD biomarkers (amyloid beta [Aβ]42/40, phosphorylated tau [p-tau]181, neurofilament light chain [NfL], and glial fibrillary acidic protein [GFAP]) may vary across populations due to ancestry-, age-, and sex-related differences. We hypothesized that these effects vary across Hispanic/Latino background groups with distinct ancestral admixture.

Methods: We analyzed ε2 and ε4 allele associations with AD biomarkers using survey-weighted linear regression models, adjusting for demographic covariates. Secondary analyses examined genetic analysis group- and ancestry-specific effects.

Results: ε4 was associated with lower Aβ42/40 and higher p-tau181and …

Detection Of Adaptive Immune Receptor Cdr3s In Tumor Proteomes And Correlations With Survival Probabilities, Arpan Sahoo, Eddie Fung, Taha Huda, Brosi Chobrutskiy, Veda Naga Priya Vangala, George Blanck

USF-LVHN SELECT

No abstract provided.

Demography And Dispersal Influence The Relationship Between Habitat Suitability And Population Density, Cleber Ten Caten, Tad Dallas

Faculty Publications

A central goal of ecology is to understand spatial patterns of species densities. Habitat suitability estimates from species distribution models (SDMs) could be used to represent species density and overcome the scarcity of density data. However, there is mixed evidence that habitat suitability is a reliable descriptor of density, and it is suggested that local dynamics affect the relationship between habitat suitability and density. We simulated population dynamics for 200 virtual species considering different combinations of factors (demographic stochasticity, dispersal, and intraspecific competition) that affect population sizes and SDMs were trained using different sets of environmental predictors to evaluate when …

The Skill Premium In Times Of Rapid Technological Change, Tarek Hassan, Aakash Kalyani, Pascual Restrepo

Cowles Foundation Discussion Papers

No abstract provided.

Plm-Effector: Unleashing The Potential Of Protein Language Models For Bacterial Secreted Protein Prediction, Dandan Zheng, Lihong Chen, Guansong Pang, Jian Yang

Research Collection School Of Computing and Information Systems

Bacterial secreted proteins, particularly effectors delivered by specialized secretion systems, are key mediators of virulence and host-pathogen interactions. However, accurate computational identification remains challenging, as many existing methods rely heavily on sequence similarity or handcrafted features, and often focus on a single secretion system. Recent studies have reported that some bacterial effectors may be associated with more than one secretion system, highlighting the complexity of secretion system annotation and motivating the development of system-aware computational prediction approaches. Here, we present PLM-Effector, a hybrid deep learning framework that integrates modern protein language models (PLMs) with multiple neural architectures via a two-layer …

Online Tutorial On Survival Analysis For Biomarker Discovery, Jaka Kokošar, Ela Praznik, Martin Špendl, Nancy P Moreno, Alana Newell, Gad Shaulsky, Blaž Zupan

Faculty, Staff and Students Publications

In biomedicine, survival analysis addresses time-to-event data to study outcomes like patient survival and treatment response, and supports biomarker discovery. Yet, teaching this analysis is often hindered by mathematical and programming barriers. We present a structured, hands-on tutorial that goes beyond a typical online guide-offering integrated video lectures, literature, quizzes, and practical exercises. Built around Orange Data Mining, an open and free no-code visual analytics platform, the tutorial covers key concepts such as censoring, Kaplan-Meier curves, group comparisons, and biomarker discovery through real-world datasets. Organized in four pedagogical units, it progresses from basic survival data analysis to gene and gene-set …

Risk Factors For Acute Rejection In Pediatric Lung Transplantation And Its Impact On Graft Failure, Sophie Li, Spoorthi Kamepalli, David Moreno Mcneill, Selena Li, Abbas Rana

Faculty, Staff and Students Publications

Background: Although acute rejection is a common complication of lung transplantation, few studies have analyzed risk factors for acute rejection in pediatric lung transplant patients. The purpose of this study was to examine risk and protective factors for acute rejection in pediatric lung transplantation and its impact on graft failure.

Methods: A retrospective analysis was performed on lung transplant data for a cohort of 906 pediatric patients from the Organ Procurement and Transplantation Network (OPTN) Database between October 1, 1987, and June 30, 2023. Multivariable logistic regression was conducted to identify risk and protective factors for acute rejection, adjusting for …

Simulation-Free Spine Palliative Radiotherapy Enabled By Ai-Adapted Diagnostic Ct, Yiding Han, Alexander Nicola Hanania, Zaid Ali Siddiqui, Vincent Ugarte, Boran Zhou, Abdallah S R Mohamed, Piyush Pathak, Daniel Allen Hamstra, Baozhou Sun

Faculty, Staff and Students Publications

Background: Radiotherapy planning traditionally requires a dedicated simulation CT (sCT), which can introduce delays in initiating treatment. This is particularly impactful in spinal palliative care, where timely treatment is often important for symptom control and prevention of neurological deterioration. Although diagnostic CT (dCT) is frequently available earlier in the workflow, it can lead to geometric and dosimetric inaccuracies when used directly for treatment planning due to discrepancies in patient positioning, vertebral alignment, and table curvature.

Purpose: To develop and evaluate an AI-based method that transforms dCT into a simulation-equivalent planning CT (AI-pCT), enabling a clinically feasible simulation-free workflow for spinal …

Defining The Society Of Pediatric Liver Transplantation (Split) Research Agenda: A Delphi Consensus Project, Sharad I Wadhwani, Pooja Reddy Spector, Amy G Feldman, Katryn N Furuya, Kayla Hartjes, Chaowapong Jarasvaraparn, Beau Kelly, Stacee M Lerret, Krupa Mysore, Arti Pawaria, Philip Rosenthal, Amy Shui, Voytek Slowik, Sarah Taylor, Jennifer Vittorio, Pamela L Valentino

Faculty, Staff and Students Publications

Background: Despite major advances in surgical and medical management, only one-third of pediatric liver transplant (LT) recipients remain morbidity-free at 10 years. The Society of Pediatric Liver Transplantation (SPLIT) published a research agenda over 10 years ago, and much progress has been made since then. An updated consensus-driven SPLIT research agenda could guide future research and funding priorities. We aimed to identify and prioritize key research needs across the continuum of pediatric LT care using a modified Delphi consensus approach.

Methods: We conducted a three-round modified Delphi process among SPLIT members. In round 1, participants submitted open-ended research priorities. In …

Adenovirus Disease Following Pediatric Liver Transplantation: 10-Year Experience From A Large Pediatric Transplant Program, Anna M Banc-Husu, Sara Hassan, N Thao N Galvan, Elizabeth A Moulton, Jeremy M Schraw, Kathleen Hosek, Dana Cerminara, Flor M Munoz, Krupa Mysore

Faculty, Staff and Students Publications

Background: Human adenovirus in immunocompromised patients can be life-threatening. We describe the prevalence, clinical presentation, and treatment of adenovirus after pediatric liver transplantation at a large transplant center.

Methods: We performed a retrospective cohort study of adenovirus infection in children from 2013 to 2022. We compared incidence, clinical characteristics, and outcomes of post-transplant children by adenovirus treatment status.

Results: Adenovirus disease developed in 26% (84/320) children after liver transplant. Median age at liver transplant was 17.5 months, 48% were female; 50% had biliary atresia. Fever (53%), gastrointestinal symptoms (48%), and hepatitis (41%) were the most common clinical presentations at diagnosis. …