Digital Commons Network^™

Development Of Pullulan/Chitosan/Salvianolic Acid Ternary Fibrous Membranes And Their Potential For Chemotherapeutic Applications, Salahuddin Ahmed, Megan Keniry, Victoria Padilla, Narcedalia Anaya-Barbosa, Md Noushad Javed, Robert Gilkerson, Kithzia Gomez, Acharan S. Narula, Karen Lozano

Mechanical Engineering Faculty Publications

This study investigates the feasibility of centrifugal spinning for producing fibrous membranes containing pullulan, chitosan, and danshen extract. The danshen extract is composed of 20 wt% salvianolic acid B (SA). Citric acid was added to the mixture as a crosslinking agent to promote its use in the aqueous medium. The influence of the danshen concentration (25 wt% and 33 wt%) on fiber morphology, thermal behavior, and the biochemical effect was analyzed. Developed fiber-based membranes consist of long, continuous, and uniform fibers with a sparse scattering of beads. Fiber diameter analysis shows values ranging from 384 ± 123 nm to 644 …

Matter Of Will Of Ratcliff And The Not-So-Harmless Error: A Call To Change Mississippi’S Approach To Will Formalities, Kelsi Baldwin

MC Law Review

A will provides a mechanism to dispose of property at death. But costly litigation—or worse, a will’s invalidation—often thwart this purpose. The law of probate is state-specific, which leaves jurisdictions with the burden of ensuring that their laws promote rather than defeat the purpose of probate—to honor the testator’s intent. Mississippi attempts to recognize this purpose by requiring strict compliance with the statutory requirements for creating a will. This “better safe than sorry” approach errs on the side of invalidity with the hope that denying a non-compliant instrument for probate will prevent fraud and other wrongdoing.

Despite its intention, Mississippi’s …

Integrating Clinical Cancer And Ptm Proteomics Data Identifies A Mechanism Of Ack1 Kinase Activation, Eranga R. Balasooriya, Deshan Madhusanka, Tania P. López-Palacios, Riley J. Eastmond, Dasun Jayatunge, Jake J. Owen, Jack S. Gashler, Christina M. Egbert, Chanaka Bulathsinghalage, Lu Liu, Stephen R. Piccolo, Joshua L. Andersen

Faculty Publications

Beyond the most common oncogenes activated by mutation (mut-drivers), there likely exists a variety of low-frequency mut-drivers, each of which is a possible frontier for targeted therapy. To identify new and understudied mut-drivers, we developed a machine learning (ML) model that integrates curated clinical cancer data and posttranslational modification (PTM) proteomics databases. We applied the approach to 62,746 patient cancers spanning 84 cancer types and predicted 3,964 oncogenic mutations across 1,148 genes, many of which disrupt PTMs of known and unknown function. The list of putative mut-drivers includes established drivers and others with poorly understood roles in cancer. This ML …

Energy, Passivity, And Morphological Capacities, Pablo Borja, Cosimo Della Santina, Azita Dabiri

School of Engineering, Computing and Mathematics

The morphology of a system may be exploited to reduce the controller workload or to perform specific tasks, e.g., locomotion processes. However, understanding and characterizing these capacities in terms of physical quantities remains an open problem. In this paper, we pose the question: are energy and dissipation useful physical quantities to characterize morphological capacities? First, to illustrate the relevance of this question, we present some basic concepts of passivity theory that are useful for carrying out an energy-based analysis of the behavior of dynamical systems. Then, we analyze the behavior of a mechanical system, and we show how its morphology …

Calculation Of Atp Production Rates Using The Seahorse Xf Analyzer, Brandon R. Desousa, Kristen K.O. Kim, Anthony E. Jones, Andréa B. Ball, Wei Y. Hsieh, Pamela Swain, Danielle H. Morrow, Alexandra J. Brownstein, David A. Ferrick, Orian S. Shirihai, Andrew Neilson, David A. Nathanson, George W. Rogers, Brian P. Dranka, Anne N. Murphy, Charles Affourtit, Steven J. Bensinger, Linsey Stiles, Natalia Romero, Ajit S. Divakaruni

School of Biomedical Sciences

Oxidative phosphorylation and glycolysis are the dominant ATP-generating pathways in mammalian metabolism. The balance between these two pathways is often shifted to execute cell-specific functions in response to stimuli that promote activation, proliferation, or differentiation. However, measurement of these metabolic switches has remained mostly qualitative, making it difficult to discriminate between healthy, physiological changes in energy transduction or compensatory responses due to metabolic dysfunction. We therefore present a broadly applicable method to calculate ATP production rates from oxidative phosphorylation and glycolysis using Seahorse XF Analyzer data and empirical conversion factors. We quantify the bioenergetic changes observed during macrophage polarization as …

Soil Adsorption Of Heavy Metals To Protect Groundwater Near Refinery Wastewater Discharge Points, Hamid A. Al-Falahi, Ferdous A. Jabir, Muthanna H. Al-Dahhan

Chemical and Biochemical Engineering Faculty Research & Creative Works

This study presents a strategy to manage the discharge of wastewater, which is either partially treated or untreated, to safeguard the groundwater reserves in the region. a case study involving Ad Diwaniyah refinery wastewater disposal into an adjacent desert was utilized to evaluate the influence of soil adsorption on the attenuation of Pb, Cu, and Cd ion concentrations. Investigation of competitive adsorption of heavy metal ions (Pb2+, Cu2+, and Cd2+) in Dolomite-Limestone soil was conducted through batch and column methods. the adsorption behavior of the bivalent metal cations was observed to be pH dependent. However, the competitive extraction of the …

Catching Elusive Depression Via Facial Micro-Expression Recognition, Xiaohui Chen, Tony Tie (T.) Luo

Computer Science Faculty Research & Creative Works

Depression is a common mental health disorder that can cause consequential symptoms with continuously depressed mood that leads to emotional distress. One category of depression is Concealed Depression, where patients intentionally or unintentionally hide their genuine emotions through exterior optimism, thereby complicating and delaying diagnosis and treatment and leading to unexpected suicides. In this article, we propose to diagnose concealed depression by using facial micro-expressions (FMEs) to detect and recognize underlying true emotions. However, the extremely low intensity and subtle nature of FMEs make their recognition a tough task. We propose a facial landmark-based Region-of-Interest (ROI) approach to address the …

Investigating Evidence In Support Of Validity And Reliability For Data Collected With The Meaningful Learning In The Laboratory Instrument (Mlli), Elizabeth Vaughan, A. Montoya-Cowan, Jack Barbera

Chemistry Faculty Publications and Presentations

The Meaningful Learning in the Laboratory Instrument (MLLI) was designed to measure students’ expectations before and after their laboratory courses and experiences. Although the MLLI has been used in various studies and laboratory environments to investigate students’ cognitive and affective laboratory expectations, the authors of the instrument reported a discrepancy between the intended factor structure of the MLLI and the factor structure suggested by the data collected in preliminary studies. Therefore, the aim of this study was to investigate the validity and reliability evidence related to data collected with the MLLI, especially that related to structural validity. Evidence to support …

Mycorrhizal Fungi Mediate Aboveground – Belowground Interactions In Forest Ecosystems, Amelia A. Fitch

Dartmouth College Ph.D Dissertations

The activities of plants and soil microbes are the primary drivers of forest ecosystem processes such as carbon (C) and nitrogen (N) cycling, and mycorrhizal fungi serve as a bridge between these two groups of organisms. The combined efforts of trees and associated mycorrhizal fungi to seek soil nutrients links C and N cycling through effects on saprotrophic communities and decomposition activity. In these studies, I investigated the effects of arbuscular (AM) and ectomycorrhizal (EcM) associations on microbial communities and ecosystem processes related to SOM decomposition and N cycling, and in turn how differences in soils beneath AM and EcM …

Combination Therapy Of Triple-Negative Breast Cancer With Paclitaxel And Ambrisentan, A Selective Antagonist Of The Endothelin Type A Receptor, Inhibits Tumor Growth And Metastasis, Farah Nasser Almahrook

Theses

Cancer treatment is a big challenge especially when associated with metastasis. Moreover, the importance of using combination therapy is increasing, especially for highly invasive, drug-resistant cancers, such as triple-negative breast cancer (TNBC). Ambrisentan, a selective antagonist of the endothelin type A receptor (ETAR) was previously shown to reduce metastasis of TNBC in a preclinical tumor model when used prophylactically. In the current study, we investigated the therapeutic potential of Ambrisentan, given as monotherapy or in combination with Paclitaxel, on TNBC. The data show that oral dosing with Ambrisentan led to a significant retardation in tumor growth and metastasis. Moreover, combining …

Identification Of A Potential Pr50gag Binding Site Critical For Selective Encapsidation Of Feline Immunodeficiency Virus (Fiv) Genomic Rna, Anjana Krishnan

Dissertations

Feline immunodeficiency virus (FIV) is an important lentivirus that causes acquired immunodeficiency syndrome (AIDS) in cats, making FIV a potential small animal model for studying the pathogenesis of human AIDS. Furthermore, due to its phylogenetic distance from primate retroviruses like human immunodeficiency virus (HIV) and its ability to infect non-dividing cells, FIV is also being exploited for the development of vectors for human gene therapy. Therefore, it is of paramount importance that pertinent steps in the life cycle of FIV, such as genomic RNA (gRNA) packaging, are delineated at the molecular level. The process of retroviral gRNA packaging relies on …

Tracing And Segmentation Of Molecular Patterns In 3-Dimensional Cryo-Et/Em Density Maps Through Algorithmic Image Processing And Deep Learning-Based Techniques, Salim Sazzed

Computer Science Theses & Dissertations

Understanding the structures of biological macromolecules is highly important as they are closely associated with cellular functionalities. Comprehending the precise organization of actin filaments is crucial because they form the dynamic cytoskeleton, which offers structural support to cells and connects the cell’s interior with its surroundings. However, determining the precise organization of actin filaments is challenging due to the poor quality of cryo-electron tomography (cryo-ET) images, which suffer from low signal-to-noise (SNR) ratios and the presence of missing wedge, as well as diverse shape characteristics of actin filaments. To address these formidable challenges, the primary component of this dissertation focuses …

Equity, Diversity, And Inclusion Annual Report, 2022-2023, Illinois State University

Equity, Diversity, and Inclusion Annual Report

Equity, Diversity, and Inclusion 2022-2023 Annual Report for Illinois State University.

Organic Carbon Decay Mediated By Mesopelagic Microbial Communities, Noah Jonathan Craft

OES Theses and Dissertations

Substantial remineralization of organic carbon occurs in the mesopelagic zone (i.e., the biological pump), the efficiency of which is responsible for the oceans’ capacity to store carbon originally derived from the atmosphere. To better understand how a substrate’s composition influences its degradation by mesopelagic microbial communities, we added treatments made of live algal cells, dead particulate organic carbon and dissolved organic carbon from ¹⁴C-labeled algal cultures to mesopelagic water collected in-situ. Each incubation took place in the laboratory over a period of months, during which PO¹⁴C, DO¹⁴C, ATP, prokaryote abundances and biochemical fractions were measured. …

The Effects Of Landscape And Yard Features On Mammal Diversity In Residential Yards Within Northwest Arkansas, Usa, Emily P. Johansson, Brett A. Degregorio

Biological Sciences Faculty Publications and Presentations

The human footprint is rapidly expanding, and wildlife habitat is continuously being converted to human residential properties. Surviving wildlife that reside in developing areas are displaced to nearby undeveloped areas. However, some animals can co-exist with humans and acquire the necessary resources (food, water, shelter) within the human environment. This ability to coexist may be particularly true when development is low intensity, as in residential suburban yards. Yards are individually managed “greenspaces” that can provide a range of food (e.g., bird feeders, compost, gardens), water (bird baths and garden ponds), and shelter (e.g., brush-piles, outbuildings) resources and are surrounded by …

The Himalayan Uplift And Evolution Of Aquatic Biodiversity Across Asia: Snowtrout (Cyprininae: Schizothorax) As A Test Case, Binod Regmi, Marlis R. Douglas, Karma Wangchuk, Zachery D. Zbinden, David R. Edds, Singye Tshering, Michael E. Douglas

Biological Sciences Faculty Publications and Presentations

Global biodiversity hotspots are often remote, tectonically active areas undergoing climatic fluctuations, such as the Himalaya Mountains and neighboring Qinghai-Tibetan Plateau (QTP). They provide biogeographic templates upon which endemic biodiversity can be mapped to infer diversification scenarios. Yet, this process can be somewhat opaque for the Himalaya, given substantial data gaps separating eastern and western regions. To help clarify, we evaluated phylogeographic and phylogenetic hypotheses for a widespread fish (Snowtrout: Cyprininae; Schizothorax) by sequencing 1,140 base pair of mtDNA cytochrome-b (cytb) from Central Himalaya samples (Nepal: N = 53; Bhutan: N = 19), augmented with 68 GenBank …

Genetic Architecture Of Soybean Tolerance To Off-Target Dicamba, Caio Canella Vieira, Jing Zhou, Diego Jarquin, Jiangfeng Zhou, Brian Diers, Dean E. Riechers, Henry T. Nguyen, Grover Shannon

Crop, Soil and Environmental Sciences Faculty Publications and Presentations

The adoption of dicamba-tolerant (DT) soybean in the United States resulted in extensive off-target dicamba damage to non-DT vegetation across soybean-producing states. Although soybeans are highly sensitive to dicamba, the intensity of observed symptoms and yield losses are affected by the genetic background of genotypes. Thus, the objective of this study was to detect novel marker-trait associations and expand on previously identified genomic regions related to soybean response to off-target dicamba. A total of 551 non-DT advanced breeding lines derived from 232 unique bi-parental populations were phenotyped for off-target dicamba across nine environments for three years. Breeding lines were genotyped …

Beyong Brackeen: Active Efforts Towards Antiracist Child Welfare Policy, Andrea Martin

Faculty Scholarship

Due to structural racism, legal protections afforded to families of children in the foster care system have been significantly eroded and continue to be challenged. The latest attempt to dismantle child welfare protections for a historically marginalized group was a prolonged attack on the Indian Child Welfare Act. Motivated in part by the racist belief that they are unfairly disadvantaged in adopting American Indian children, American Indian adversaries reached the pinnacle of their incessant attack on the law’s constitutionality and its heightened requirements. Fortunately, in Haaland v. Brackeen, the United States Supreme Court upheld the law’s important protections for …

Exit Engineering, Rachel Landy

Articles

How do business lawyers create value? For nearly forty years, scholars have conceptualized the business lawyer as a “transaction cost engineer” who helps contracting parties efficiently break negotiation stalemates to create more valuable deals. This theory provides meaningful insights about sophisticated corporate law practice, where outside lawyers parachute in to make one-off deals happen. However, it fails to explain the behavior of startup lawyers, who develop long-term relationships with their clients and counsel them on seemingly routine matters, well before a major transaction materializes. These lawyers are not just transaction cost engineers, they are exit engineers. This Article offers a …

Habitat-Mediated Efficacy Of 360 Degree Diver-Operated Video For Quantitative Surveys Of California Reef Fishes, Kameron Strickland

Capstone Projects and Master's Theses

Temperate rocky reefs feature a mosaic of complex macrohabitat features which host a variety of demersal fish species. Giant kelp forests add considerable vertical structure to rocky reefs, including macrohabitats extending from the reef to the upper water column. Much of what we know about temperate communities derives from shallow SCUBA surveys in which divers record observations using underwater visual census (UVC) techniques. Increasingly, these communities are being studied with video techniques first utilized in deeper water. While UVC provides immediate data on fish communities and requires no additional technology either for data collection or post-processing, imagery captures the fine-scale …

Uni Schedule Of Classes: Policies And Procedures, Fall 2023, University Of Northern Iowa

UNI Schedule of Classes

A listing and schedule of the courses being taught as well as policies and procedures concerning attending classes at the University of Northern Iowa.

Potent Bile Acid Microbial Metabolites Modulate Clostridium Perfringens Virulence, Tahrir Jatli Alenezi, Ying Fu, Bilal Alrubaye, Thamer Alanazi, Ayidh Almansour, Hong Wang, Xiaolun Sun

Poultry Science Faculty Publications and Presentations

Clostridium perfringens is a versatile pathogen, inducing diseases in the skin, intestine (such as chicken necrotic enteritis (NE)), and other organs. The classical sign of NE is the foul smell gas in the ballooned small intestine. We hypothesized that deoxycholic acid (DCA) reduced NE by inhibiting C. perfringens virulence signaling pathways. To evaluate the hypothesis, C. perfringens strains CP1 and wild-type (WT) HN13 and its mutants were cultured with different bile acids, including DCA and isoallolithocholic acid (isoalloLCA). Growth, hydrogen sulfide (H₂S) production, and virulence gene expression were measured. Notably, isoalloLCA was more potent in reducing growth, H …

Editorial: Parasitism: The Good, The Bad And The Ugly, Marco A. Juarez-Estrada, Danielle Graham, Xochitl Hernandez-Velasco, Guillermo Tellez-Isaias

Poultry Science Faculty Publications and Presentations

Editorial on the Research Topic

Parasitism: the good, the bad and the ugly

Firearm Contagion: A New Look At History, Rachel Martin, Michael R. Ulrich

Faculty Scholarship

Gun violence is widely considered a serious public health problem in the United States, but less understood is what this means, if anything, for evolving Second Amendment doctrine. In New York Pistol & Rifle Association, Inc. v. Bruen, the Supreme Court held that laws infringing Second Amendment rights can only be sustained if the government can point to sufficient historical analogues. Yet, what qualifies as sufficiently similar, a suitable number of jurisdictions, or the most important historical eras all remain unclear. Under Bruen, lower courts across the country have struck down gun laws at an alarming pace, while …

Need-Oriented Evangelism: Encountering, Embracing, And Experiencing God, Petr Cincala, Allison Sauceda

Faculty Publications

This article provides a fresh perspective on evangelism by reflecting a belief in the Triune God--the source of saving truth and loving community. Mission is part of God’s nature; he is the ultimate Missionary. Mission happens naturally whenever children of God intentionally invite and facilitate God’s presence. Over time, the word “evangelism" has become contaminated by myths, a false understanding of God, and unpleasant religious experiences and practices. Genuine evangelism addresses the most burning issues of people’s lives and should be treated as such. True evangelism involves caring about, praying for, and sharing with people. The practical part of this …

Cyber Fraud Profiling With Routine Activity Theory Using Data Mining Techniques, Sunardi Sunardi, Abdul Fadlil, Nur Makkie Perdana Kusuma

Malaysian Journal of Computing (MJoC)

Cyber profiling, as one of the supporting parts of digital forensics, is not only used to record and investigate cybercriminal behaviour. It can also be used to profile victim demographics based on victim characteristics. This study aims to create a cyber-fraud pattern based on a profile created from RAT. This research is expected to be input for internet users in Indonesia, especially IM users such as Instagram, Facebook, WhatsApp, and Telegram. The data collection method in this study uses data mining technology on structured and unstructured data. Structured data was obtained by conducting data mining on the number of cases …

Modelling Time Series Tropospheric Ozone Data And The Precursors To Study Effect And Relationship, Emilya Shahira Azli, Nurazrin Syafiqah Mat Asri, Siti Nurliyani Ahmad Tajuddin, Norshahida Shaadan, Siti Afiqah Muhamad Jamil, Shamsiah Sapri

Malaysian Journal of Computing (MJoC)

Understanding the role of pollutant precursors is very important to provide meaningful insights for planning and designing localized air pollution control strategies.  This study is conducted with the aim of describing the relationship and assessing the effect of several precursors (OX, NO, NO2, SO2, CO) towards O3 using Multiple Linear Regression (MLR) at an industrial (Petaling Jaya) and an urban (Shah Alam) location in Selangor, Peninsular Malaysia. Statistical modelling and analysis were conducted based on secondary data of time-series observations of multi-variables from the period of the year 2015-2017 obtained from the Department of Environment, Malaysia. Two models were developed, …

Vulgarized Neighbouring Network Of Multivariate Autoregressive Processes Of With Student-T Distri, Rasaki Olawale Olanrewaju, Ravi Prakash Ranjan, Queensley C. Chukwudum, Sodiq Adejare Olanrewaju

Malaysian Journal of Computing (MJoC)

This paper introduces the vulgarized network autoregressive process with Gaussian and Student-t random noises. The processes relate the time-varying series of a given variable to the immediate past of the same phenomenon with the inclusion of its neighboring variables and networking structure. The generalized network autoregressive process would be fully spelt-out to contain the aforementioned random noises with their embedded parameters (the autoregressive coefficients, networking nodes, and neighboring nodes) and subjected to monthly prices of ten (10) edible cereals. Global-α of Generalized Network Autoregressive (GNAR) of order lag two, the neighbor at the time lags two and the neighbourhood nodal …

Qtls And Candidate Loci Associated With Drought Tolerance Traits Of Kaybonnet X Zhe733 Recombinant Inbred Lines Rice Population, Yheni Dwiningsih, Julie Thomas, Anuj Kumar, Chirag Gupta, Navdeep Gill, Charles Ruiz, Jawaher Alkahtani, Niranjan Baisakh, Andy Pereira

Crop, Soil and Environmental Sciences Faculty Publications and Presentations

Rice is the most important staple crop for the sustenance of the world’s population, and drought is a major factor limiting rice production. Quantitative trait locus (QTL) analysis of drought-resistance-related traits was conducted on a recombinant inbred line (RIL) population derived from the self-fed progeny of a cross between the drought-resistant tropical japonica U.S. adapted cultivar Kaybonnet and the drought-sensitive indica cultivar ZHE733. K/Z RIL population of 198 lines was screened in the field at Fayetteville (AR) for three consecutive years under controlled drought stress (DS) and well-watered (WW) treatment during the reproductive stage. The effects of DS were quantified …

Comparison Of A Patient-Specific Computed Tomography Organ Dose Software With Commercial Phantom-Based Tools, Bindu P. Bhat

Master's Theses (2009 -)

Computed Tomography imaging is an important diagnostic tool but carries some risk due to radiation dose used to form the image. Currently, CT scanners report a measure of radiation dose for each scan that reflects the radiation emitted by the scanner, not the radiation dose absorbed by the patient. The radiation dose absorbed by organs, known as organ dose, is a more relevant metric that is important for risk assessment and CT protocol optimization. Tools for rapid organ-dose estimation are available but are limited to using general patient models. These publicly available tools are unable to model patient-specific anatomy and …