Digital Commons Network^™

Vulgarized Neighbouring Network Of Multivariate Autoregressive Processes Of With Student-T Distri, Rasaki Olawale Olanrewaju, Ravi Prakash Ranjan, Queensley C. Chukwudum, Sodiq Adejare Olanrewaju

Malaysian Journal of Computing (MJoC)

This paper introduces the vulgarized network autoregressive process with Gaussian and Student-t random noises. The processes relate the time-varying series of a given variable to the immediate past of the same phenomenon with the inclusion of its neighboring variables and networking structure. The generalized network autoregressive process would be fully spelt-out to contain the aforementioned random noises with their embedded parameters (the autoregressive coefficients, networking nodes, and neighboring nodes) and subjected to monthly prices of ten (10) edible cereals. Global-α of Generalized Network Autoregressive (GNAR) of order lag two, the neighbor at the time lags two and the neighbourhood nodal …

Qtls And Candidate Loci Associated With Drought Tolerance Traits Of Kaybonnet X Zhe733 Recombinant Inbred Lines Rice Population, Yheni Dwiningsih, Julie Thomas, Anuj Kumar, Chirag Gupta, Navdeep Gill, Charles Ruiz, Jawaher Alkahtani, Niranjan Baisakh, Andy Pereira

Crop, Soil and Environmental Sciences Faculty Publications and Presentations

Rice is the most important staple crop for the sustenance of the world’s population, and drought is a major factor limiting rice production. Quantitative trait locus (QTL) analysis of drought-resistance-related traits was conducted on a recombinant inbred line (RIL) population derived from the self-fed progeny of a cross between the drought-resistant tropical japonica U.S. adapted cultivar Kaybonnet and the drought-sensitive indica cultivar ZHE733. K/Z RIL population of 198 lines was screened in the field at Fayetteville (AR) for three consecutive years under controlled drought stress (DS) and well-watered (WW) treatment during the reproductive stage. The effects of DS were quantified …

Comparison Of A Patient-Specific Computed Tomography Organ Dose Software With Commercial Phantom-Based Tools, Bindu P. Bhat

Master's Theses (2009 -)

Computed Tomography imaging is an important diagnostic tool but carries some risk due to radiation dose used to form the image. Currently, CT scanners report a measure of radiation dose for each scan that reflects the radiation emitted by the scanner, not the radiation dose absorbed by the patient. The radiation dose absorbed by organs, known as organ dose, is a more relevant metric that is important for risk assessment and CT protocol optimization. Tools for rapid organ-dose estimation are available but are limited to using general patient models. These publicly available tools are unable to model patient-specific anatomy and …

Sustained Antidepressant Effect Of Ketamine Through Nmdar Trapping In The Lhb, Shuangshuang Ma, Christopher J Lingle, Et Al.

2020-Current year OA Pubs

Ketamine, an N-methyl-D-aspartate receptor (NMDAR) antagonist

Glimpses Of Oregon’S Sea Otters, Cameron La Follette, Douglas Deur

Anthropology Faculty Publications and Presentations

Sea otters are an iconic species in the history of what is now known as Oregon. Their pelts brought great wealth in late eighteenth and nineteenth century China, motivating some of Oregon’s earliest exploration, trade, and contact between Native American and Euro-American people. Over time, hunting eliminated the species from Oregon’s coastal waters. This article provides a broad introduction to the history of Oregon’s now-extinct sea otter population, describing the emergence of the Chinese market that created and sustained the hunt, the British discovery of profits to be made by trading for the pelts, and the rise of American traders. …

Fall 2023 Shsp Alumni Connections, New York Medical College

School of Health Sciences and Practice

• Founder's Dinner 2023
• SHSP Renovations for the New Academic Year
• NYMC Alumna Dr. Blanco Appointed SLP Director of Clinical Education
• Mock Interview Day for the D.P.T. Class of 2024
• SLP Hosts Cricket Activity for First-Year Students
• Clinical Skills and Simulation Center Looks Forward to Expansion
• Golf Outing Supports Student Scholarships
• NYMC and TU Hosts Webinar Series: “Ninety Minutes: The Medical Magazine of the Web”
• Sambit Mohapatra, Ph.D., M.S., PT, Is Named Chair of the Department of Rehabilitation Sciences
• Katherine Paulino-Gomez, M.A., CCC-SLP, Brings Unique Perspective to SLP Faculty
• Meet the President of NYMC Student Health Care Executives
• From Healing Communities …

Fall 2023 Som Alumni Connections, New York Medical College

School of Medicine

• Founder's Dinner 2023
• Neil W. Schluger, M.D., Named Dean of the School of Medicine
• Dr. Pamela Ludmer Appointed Interim Dean for Undergraduate Medical Education
• Clinical Skills and Simulation Center Looks Forward to Expansion
• Non-Invasive Test Can Detect Oral and Throat Cancer at Early Stages
• NYMC and Regeneron Pharmaceuticals Collaborate on Drug Development Elective
• Intranasal Immunization Offers Stronger Protection Against COVID-19
• Golf Outing Supports Student Scholarships
• Drs. Abraham and Moscatello Return to Ukraine to Train Reconstructive Plastic Surgeons
• Medical Students Mark Transition to Clinical Practice
• SOM Welcomes Student Senate E-Board Officers
• SOM Class of 2027 Dons White Coats for the First …

If You Build It, They Will Come: Coastal Amenities Facilitate Human Engagement In Marine Protected Areas, Christopher M. Free, Joshua G. Smith, Cori J. Lopazanski, Julien Brun, Tessa B. Francis, Jacob G. Eurich, Joachim Claudet, Jenifer E. Dugan, David A. Gill, Scott L. Hamilton, Kristin Kaschner, David Mouillot, Shelby L. Ziegler, Jennifer E. Caselle, Kerry J. Nickols

Faculty Research, Scholarly, and Creative Activity

Calls for using marine protected areas (MPAs) to achieve goals for nature and people are increasing globally. While the conservation and fisheries impacts of MPAs have been comparatively well-studied, impacts on other dimensions of human use have received less attention. Understanding how humans engage with MPAs and identifying traits of MPAs that promote engagement is critical to designing MPA networks that achieve multiple goals effectively, equitably and with minimal environmental impact. In this paper, we characterize human engagement in California's MPA network, the world's largest MPA network scientifically designed to function as a coherent network (124 MPAs spanning 16% of …

A Marine Protected Area Network Does Not Confer Community Structure Resilience To A Marine Heatwave Across Coastal Ecosystems, Joshua G. Smith, Christopher M. Free, Cori Lopazanski, Julien Brun, Clarissa R. Anderson, Mark H. Carr, Joachim Claudet, Jenifer E. Dugan, Jacob G. Eurich, Tessa B. Francis, Scott L. Hamilton, David Mouillot, Peter T. Raimondi, Richard M. Starr, Shelby L. Ziegler, Kerry J. Nickols, Jennifer E. Caselle

Faculty Research, Scholarly, and Creative Activity

Marine protected areas (MPAs) have gained attention as a conservation tool for enhancing ecosystem resilience to climate change. However, empirical evidence explicitly linking MPAs to enhanced ecological resilience is limited and mixed. To better understand whether MPAs can buffer climate impacts, we tested the resistance and recovery of marine communities to the 2014–2016 Northeast Pacific heatwave in the largest scientifically designed MPA network in the world off the coast of California, United States. The network consists of 124 MPAs (48 no-take state marine reserves, and 76 partial-take or special regulation conservation areas) implemented at different times, with full implementation completed …

Genomic Approaches To Mitigating Genetic Diversity Loss In Declining Populations, Christen M. Bossu, Marina Rodriguez, Christine Rayne, Debra A. Chromczak, Philip G. Higgins, Lynne A. Trulio, Kristen C. Ruegg

Faculty Research, Scholarly, and Creative Activity

The accelerating pace of global biodiversity loss is exacerbated by habitat fragmentation and subsequent inbreeding in small populations. To address this problem, conservation practitioners often turn to assisted breeding programmes with the aim of enhancing genetic diversity in declining populations. Although genomic information is infrequently included in these efforts, it has the potential to significantly enhance the success of such programmes. In this study, we showcase the value of genomic approaches for increasing genetic diversity in assisted breeding efforts, specifically focusing on a highly inbred population of Western burrowing owls. To maximize genetic diversity in the resulting offspring, we begin …

Magnitude, Trends, And Variability Of The Global Ocean Carbon Sink From 1985 To 2018, Tim Devries, Kana Yamamoto, Rik Wanninkhof, Nicolas Gruber, Judith Hauck, Jens Daniel Müller, Laurent Bopp, Dustin Carroll, Brendan Carter, Thi Tuyet Trang Chau, Scott C. Doney, Marion Gehlen, Lucas Gloege, Luke Gregor, Stephanie Henson, Ji Hyun Kim, Yosuke Iida, Tatiana Ilyina, Peter Landschützer

Faculty Research, Scholarly, and Creative Activity

This contribution to the RECCAP2 (REgional Carbon Cycle Assessment and Processes) assessment analyzes the processes that determine the global ocean carbon sink, and its trends and variability over the period 1985–2018, using a combination of models and observation-based products. The mean sea-air CO2 flux from 1985 to 2018 is −1.6 ± 0.2 PgC yr−1 based on an ensemble of reconstructions of the history of sea surface pCO2 (pCO2 products). Models indicate that the dominant component of this flux is the net oceanic uptake of anthropogenic CO2, which is estimated at −2.1 ± 0.3 PgC yr−1 by an ensemble of ocean …

Striving To Increase Bipoc Family Participation In Early Childhood Family Education, Ayuko Boomer

School of Education and Leadership Student Capstone Theses and Dissertations

Boomer, A. U. (2023). Striving to Increase BIPOC Family Participation in Early Childhood Family Education. Early Childhood Family Education (ECFE) is a public education program designed and available for all parents and families in Minnesota. Despite these intentions, many Black, Indigenous, and People of Color (BIPOC) families remain unaware of ECFE's existence and its significance. The purpose of this study is to understand the current methodologies of parent education outreach and collaboration with other programs, in particular, BIPOC communities, and explore and process what efforts have been made to increase BIPOC participation in traditional ECFE parent education group classes (non-affinity …

Regulation Of Tumor Apoptosis Of Poriae Cutis-Derived Lanostane Triterpenes By Akt/Pi3k And Mapk Signaling Pathways In Vitro, Shuai Yue, Xi Feng, Yousheng Cai, Salam A. Ibrahim, Ying Liu, Wen Huang

Faculty Research, Scholarly, and Creative Activity

Poria cocos is traditionally used as both food and medicine. Triterpenoids in Poria cocos have a wide range of pharmacological activities, such as diuretic, sedative and tonic properties. In this study, the anti-tumor activities of poricoic acid A (PAA) and poricoic acid B (PAB), purified by high-speed counter-current chromatography, as well as their mechanisms and signaling pathways, were investigated using a HepG2 cell model. After treatment with PAA and PAB on HepG2 cells, the apoptosis was obviously increased (p < 0.05), and the cell cycle arrested in the G2/M phase. Studies showed that PAA and PAB can also inhibit the occurrence and development of tumor cells by stimulating the generation of ROS in tumor cells and inhibiting tumor migration and invasion. Combined Polymerase Chain Reaction and computer simulation of molecular docking were employed to explore the mechanism of tumor proliferation inhibition by PAA and PAB. By interfering with phosphatidylinositol-3-kinase/protein kinase B, Mitogen-activated protein kinases and p53 signaling pathways; and further affecting the expression of downstream caspases; matrix metalloproteinase family, cyclin-dependent kinase -cyclin, Intercellular adhesion molecules-1, Vascular Cell Adhesion Molecule-1 and Cyclooxygenase -2, may be responsible for their anti-tumor activity. Overall, the results suggested that PAA and PAB induced apoptosis, halted the cell cycle, and inhibited tumor migration and invasion through multi-pathway interactions, which may serve as a potential therapeutic agent against cancer.

Work–Family Conflict And Its Sustainability Implications Among Married Immigrants Working In The Usa, Neena Gopalan, Nicholas J. Beutell, Joseph G. Grzywacz, Wendy Middlemiss, Srikant Manchiraju, Sapna Srivastava

Faculty Research, Scholarly, and Creative Activity

There is a paucity of research on the work and family dynamics of immigrants who arrive in the U.S. on visas. Work–family conflict among immigrants is a sustainability issue because it affects social cohesion, economic vitality, and the overall wellbeing of communities. This study examined work–family conflicts and work–life support among married immigrants (n = 182) born abroad but currently holding permanent resident status (also known as ‘green card holders’) in the U.S. Specifically, we examined how work variables (job intensity and work–life support) may either lead to or reduce job burnout, how burnout may be related to work–family conflict, …

Food Perception: Taste, Smell And Flavour, Yanping Chen, Ying Liu, Xi Feng

Faculty Research, Scholarly, and Creative Activity

No abstract provided.

Mixed-Up Origins: The Case For A Gestational Presumption In Embryo Mix-Ups, Betsy A. Sugar

Vanderbilt Law Review

Embryo mix-ups-instances in which fertility clinics mistakenly implant one couple with another couple's embryo confound courts' determinations of who, between the two couples, are the legal parents. Lax regulation of the fertility industry permitted this relatively new injury to develop, and it has led to morally and legally fraught questions of parenthood and personal autonomy. This Note reviews parentage doctrines, beginning with a discussion of the martial presumption; it also tracks how courts have traditionally responded to parentage questions that fertility medicine has generated, including embryo division in divorce and parentage in surrogacy contracts. It then analyzes potential approaches to …

Dean's Update, October 2023, Neil W. Schluger

SOM Dean's Research Newsletter

No abstract provided.

Dean's Report- Fall 2023, Marina K. Holz

GSBMS Dean’s Report

No abstract provided.

Mammalian Aging Driven By Transcription Going Awry, Brenna S Mccauley, Weiwei Dang

Faculty, Staff and Students Publications

The mechanisms that underlie increased cryptic transcription during senescence and aging have been poorly understood. Sen et al. recently identified cryptic transcription start sites (cTSSs) and chromatin state changes that may contribute to cTSS activation in mammals. Their results indicate that enhancer-promoter conversion may drive cryptic transcription in senescence.

Prevalence Of Pathogenic Germline Variants In Adult-Type Diffuse Glioma, Malcolm F Mcdonald, Lyndsey L Prather, Cassandra R Helfer, Ethan B Ludmir, Alfredo E Echeverria, Shlomit Yust-Katz, Akash J Patel, Benjamin Deneen, Ganesh Rao, Ali Jalali, Shweta U Dhar, Chris I Amos, Jacob J Mandel

Faculty, Staff and Students Publications

BACKGROUND: No consensus germline testing guidelines currently exist for glioma patients, so the prevalence of germline pathogenic variants remains unknown. This study aims to determine the prevalence and type of pathogenic germline variants in adult glioma.

METHODS: A retrospective review at a single institution with paired tumor/normal sequencing from August 2018-April 2022 was performed and corresponding clinical data were collected.

RESULTS: We identified 152 glioma patients of which 15 (9.8%) had pathogenic germline variants. Pathogenic germline variants were seen in 11/84 (13.1%) of Glioblastoma, IDH wild type; 3/42 (7.1%) of Astrocytoma, IDH mutant; and 1/26 (3.8%) of Oligodendroglioma, IDH mutant, …

Human Glp1r Variants Affecting Glp1r Cell Surface Expression Are Associated With Impaired Glucose Control And Increased Adiposity, Wenwen Gao, Lei Liu, Eunna Huh, Florence Gbahou, Erika Cecon, Masaya Oshima, Ludivine Houzé, Panagiotis Katsonis, Alan Hegron, Zhiran Fan, Guofei Hou, Guillaume Charpentier, Mathilde Boissel, Mehdi Derhourhi, Michel Marre, Beverley Balkau, Philippe Froguel, Raphael Scharfmann, Olivier Lichtarge, Julie Dam, Amélie Bonnefond, Jianfeng Liu, Ralf Jockers

Faculty, Staff and Students Publications

The glucagon-like peptide 1 receptor (GLP1R) is a major drug target with several agonists being prescribed in patients with type 2 diabetes (T2D) and obesity 1, 2. The impact of genetic variability of GLP1R on receptor function and its association with metabolic traits are unclear with conflicting reports. Here, we performed a functional profiling of 60 GLP1R variants across four signaling pathways and revealed an unexpected diversity of phenotypes ranging from defective cell surface expression to complete or pathway-specific gain- (GoF) and loss-of-functions (LoF). The defective insulin secretion of GLP1R LoF variants was rescued by allosteric GLP1R ligands …

Best Practices For Effective Management Of Point Of Care Testing, Anil K Chokkalla, Brandy D Recio, Sridevi Devaraj

Faculty, Staff and Students Publications

With the recent COVID-19 pandemic, point-of-care testing has gained tremendous attention, particularly in acute care settings. The point-of-care testing landscape is rapidly expanding and being contemplated for any crucial test with a central laboratory turnaround time >25% of the clinical decision time. A typical point-of-care testing program within a large hospital system encompasses a multitude of operators utilizing a wide range of devices across multiple testing sites. Thus, managing a large point-of-care testing network remains a daunting task with challenges related to staffing, standardization, quality management, training and competency assessment, and data management. This review will focus on understanding the …

The Improving Medication Adherence In Adolescents And Young Adults Following Liver Transplantation (Imalt) Multisite Trial: Design And Trial Implementation Considerations, Eyal Shemesh, Sarah Duncan-Park, George Mazariegos, Rachel Annunziato, Ravinder Anand, Miguel Reyes-Mugica, Jeff Mitchell, Benjamin L Shneider

Faculty, Staff and Students Publications

BACKGROUND/AIMS: Medication non-adherence is a leading cause of transplant rejection, organ loss, and death; yet no rigorous controlled study to date has shown compelling clinical benefits from an adherence-improving intervention. Non-adherent patients are less likely to participate in trials, and therefore, most studies enroll a majority of adherent patients who do not stand to benefit from the intervention, as they do not have the condition (non-adherence) under investigation. The improving Medication Adherence in adolescent Liver Transplant recipients trial specifically targets non-adherent patients to investigate whether a remote intervention to improve adherence results in reduced incidence of biopsy-confirmed rejection.

METHODS: Improving …

Review Of Toxocariasis At A Children's Hospital Prompting Need For Public Health Interventions, Mary B Fortini, Timothy A Erickson, Lauren M Leining, Karina M Robinson, Megan N Carey, Sarah J Smith, Brendan Sullivan, Alisa R Nelson, Sarah M Gunter, Jill E Weatherhead

Faculty, Staff and Students Publications

BACKGROUND: Toxocariasis, caused the by dog and cat roundworm, is one of the most common zoonotic helminth infections in the United States and can lead to severe lifelong morbidity in children. Although historical seroprevalence studies have identified a high frequency of toxocariasis regionally in the United States, there are few studies linking epidemiology and clinical disease in children. The study objective was to examine the contemporary epidemiology of pediatric toxocariasis within an endemic US region.

METHODS: We conducted an epidemiologic study analyzing children diagnosed with toxocariasis presenting to a tertiary pediatric hospital in Texas from 2010 to 2021. We examined …

Bronchopulmonary Dysplasia – Associated Pulmonary Hypertension: An Updated Review, Ahmed El-Saie, Nidhy P Varghese, Melissa K Webb, Natalie Villafranco, Bheru Gandhi, Milenka Cuevas Guaman, Binoy Shivanna

Faculty, Staff and Students Publications

Bronchopulmonary dysplasia (BPD) is the leading cause of chronic lung disease in infants and the commonest complication of prematurity. Advances in respiratory and overall neonatal care have increased the survival of extremely low gestational age newborns, leading to the continued high incidence of BPD. Pulmonary hypertension (PH) represents the severe form of the pulmonary vascular disease associated with BPD, and affects almost one-third of infants with moderate to severe BPD. PH responds suboptimally to pulmonary vasodilators and increases morbidity and mortality in BPD infants. An up-to-date knowledge of the pathogenesis, pathophysiology, diagnosis, treatment, and outcomes of BPD-PH can be helpful …

A Novel Pathogenic Mutation Of Mecp2 Impairs Chromatin Association Independent Of Protein Levels, Jian Zhou, Claudia Cattoglio, Yingyao Shao, Harini P Tirumala, Carlo Vetralla, Sameer S Bajikar, Yan Li, Hu Chen, Qi Wang, Zhenyu Wu, Bing Tang, Mahla Zahabiyon, Aleksandar Bajic, Xiangling Meng, Jack J Ferrie, Anel Lagrone, Ping Zhang, Jean J Kim, Jianrong Tang, Zhandong Liu, Xavier Darzacq, Nathaniel Heintz, Robert Tjian, Huda Y Zoghbi

Faculty, Staff and Students Publications

Loss-of-function mutations in MECP2 cause Rett syndrome (RTT), a severe neurological disorder that mainly affects girls. Mutations in MECP2 do occur in males occasionally and typically cause severe encephalopathy and premature lethality. Recently, we identified a missense mutation (c.353G>A, p.Gly118Glu [G118E]), which has never been seen before in MECP2, in a young boy who suffered from progressive motor dysfunction and developmental delay. To determine whether this variant caused the clinical symptoms and study its functional consequences, we established two disease models, including human neurons from patient-derived iPSCs and a knock-in mouse line. G118E mutation partially reduces MeCP2 abundance …

Recent Insights Into The Pathogenesis And Therapeutic Targets Of Chronic Liver Diseases, Yankai Wen, Lichun Ma, Cynthia Ju

Faculty, Staff and Student Publications

Viral hepatitis, alcohol-associated liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD) are the three major causes of chronic liver diseases, which account for approximately 2 million deaths per year worldwide. The current direct-acting antiviral drugs and vaccinations have effectively reduced and ameliorated viral hepatitis infection, but there are still no effective drug treatments for ALD, NAFLD and liver cancer due to the poor understanding of their pathogenesis. To better understand the pathogenesis, the fifth Chinese American Liver Society/Society of Chinese Bioscientists in America Hepatology Division Annual Symposium, which was held virtually on 21-22 October 2022, focused on the topics …

Age-Related Differences In The Contribution Of Systolic Blood Pressure And Biomarkers To Cardiovascular Disease Risk Prediction: The Atherosclerosis Risk In Communities (Aric) Study, Mahmoud Al Rifai, George E Taffet, Kunihiro Matsushita, Salim S Virani, James De Lemos, Amit Khera, Jarrett Berry, Chiadi Ndumele, David Aguilar, Caroline Sun, Ron C Hoogeveen, Elizabeth Selvin, Christie M Ballantyne, Vijay Nambi

Faculty, Staff and Students Publications

We sought to determine how biomarkers known to be associated with hypertension-induced end-organ injury complement the use of systolic blood pressure (SBP) for cardiovascular disease (CVD) risk prediction at different ages. Using data from visits 2 (1990 to 1992) and 5 (2011 to 2013) of the Atherosclerosis Risk in Communities (ARIC) study, 3 models were used to predict CVD (composite of coronary heart disease, stroke, and heart failure). Model A included traditional risk factors (TRFs) except SBP, model B-TRF plus SBP, and model C-TRF plus biomarkers (high-sensitivity troponin T [hsTnT] and N-terminal pro-B-type natriuretic peptide [NT-proBNP]). Harrel's C-statistics were used …

Fatigue In Patients Receiving Maintenance Hemodialysis: A Review, Maurizio Bossola, S Susan Hedayati, Astrid D H Brys, L Parker Gregg

Faculty, Staff and Students Publications

Fatigue surrounding hemodialysis treatments is a common and often debilitating symptom that impacts patients' quality of life. Intradialytic fatigue develops or worsens immediately before hemodialysis and persists through the dialysis treatment. Little is known about associated risk factors or pathophysiology, although it may relate to a classic conditioning response. Postdialysis fatigue (PDF) develops or worsens after hemodialysis and may persist for hours. There is no consensus on how to measure PDF. Estimates for the prevalence of PDF range from 20%-86%, likely due to variation in methods of ascertainment and participant characteristics. Several hypotheses seek to explain the pathophysiology of PDF, …

Molecular Insights Using Spatial Transcriptomics Of The Distal Lung In Congenital Diaphragmatic Hernia, Krithika Lingappan, Oluyinka O Olutoye, Abiud Cantu, Manuel Eliezer Cantu Gutierrez, Nahir Cortes-Santiago, J D Hammond, Jamie Gilley, Joselyn Rojas Quintero, Hui Li, Francesca Polverino, Jason P Gleghorn, Sundeep G Keswani

Faculty, Staff and Students Publications

Abnormal pulmonary vascular development and function in congenital diaphragmatic hernia (CDH) is a significant factor leading to pulmonary hypertension. The lung is a very heterogenous organ and has marked cellular diversity that is differentially responsive to injury and therapeutic agents. Spatial transcriptomics provides the unmatched capability of discerning the differences in the transcriptional signature of these distinct cell subpopulations in the lung with regional specificity. We hypothesized that the distal lung parenchyma (selected as a region of interest) would show a distinct transcriptomic profile in the CDH lung compared with control (normal lung). We subjected lung sections obtained from male …