Digital Commons Network^™

A Translational Blueprint For Developing Intraoperative Imaging Agents Via Radiopharmaceutical-Guided Drug Design, Teresa E Sullivan, Servando Hernandez Vargas, Sukhen C Ghosh, Solmaz Aghaamiri, Naruhiko Ikoma, Ali Azhdarinia

Faculty, Staff and Student Publications

Cancer imaging is a rapidly evolving field due to the discovery of novel molecular targets and the availability of corresponding techniques to detect them with high precision, accuracy, and sensitivity. Nuclear medicine is the most widely used molecular imaging modality and has a growing toolkit of clinically used radiopharmaceuticals that enable whole-body tumor visualization, staging, and treatment monitoring for a variety of tumors in a non-invasive manner. The need for similar imaging capabilities in the operating room has led to the emergence of fluorescence-guided surgery (FGS) as a powerful technique that gives surgeons unprecedented ability to distinguish tumors from healthy …

Pd-1 Blockade In Combination With Dasatinib Potentiates Induction Of Anti-Acute Lymphocytic Leukemia Immunity, Paul Koller, Natalia Baran, Karine Harutyunyan, Antonio Cavazos, Saradhi Mallampati, Renee L Chin, Zhou Jiang, Xian Sun, Heng-Huan Lee, Jennifer L Hsu, Patrick Williams, Xuelin Huang, Michael A Curran, Mien-Chie Hung, Marina Konopleva

Faculty, Staff and Student Publications

Immunotherapy, in the form of hematopoietic stem cell transplantation (HSCT), has been part of the standard of care in the treatment of acute leukemia for over 40 years. Trials evaluating novel immunotherapeutic approaches, such as targeting the programmed death-1 (PD-1) pathway, have unfortunately not yielded comparable results to those seen in solid tumors. Major histocompatibility complex (MHC) proteins are cell surface proteins essential for the adaptive immune system to recognize self versus non-self. MHC typing is used to determine donor compatibility when evaluating patients for HSCT. Recently, loss of MHC class II (MHC II) was shown to be a mechanism …

A New Key To Sustainable Farming: A New Wave Of Pesticides Has The Potential To Change Farming, Michael E. Harvey

The Synapse: Intercollegiate science magazine

No abstract provided.

The Renewable Frontier: Improving Offshore Wind Development Within The Great Lakes Through Statutory Initiatives, Anjelica D. Blair

Case Western Reserve Law Review

No abstract provided.

Sex And Stress Modulate Pupal Defense Response In Tobacco Hornworm, Sukhman Singh, Sakshi Watts, Ishveen Kaur, Isabella Rodriguez, Jessica Ayala, Dariela Rodriguez, Elian Martin, Rupesh R. Kariyat

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Biology)

In insects, larval and adult defenses against predators have been well studied. However, pupal (also known as resting stage) defenses have been overlooked and not examined thoroughly. Although some pupa possess antipredator strategies such as hairs, spines, cryptic coloration, and exudation of chemicals, few studies have tested these responses and the factors affecting them. Here, we investigated the behavioral responses in tobacco hornworm Manduca sexta that pupates in soil by introducing an external stimulus using vibrations from an electric toothbrush to mimic predation. We observed that M. sexta made violent wriggling (twitching), followed by pulsating movements in response to the …

The Aviation Illusion-Situational Judgment Test: Development And Evaluation, John Kleber

Doctoral Dissertations and Master's Theses

Situational judgment tests (SJTs) are scenario-based assessments that evaluate an individual's capacity to make key judgments relating to specific contexts. While SJTs are traditionally used for personal selection (e.g., managers, customer service personnel, and police officers), SJTs also demonstrate potential for use in training evaluation. One area of interest in aviation is aeronautical decision-making (ADM) during inflight encounters with aviation illusions. However, a gap in research exists regarding how to measure pilots’ capacity to make judgments about illusions during flight.

This dissertation aimed to develop and validate an SJT that evaluates aeronautical decision-making (ADM) during inflight encounters with aviation illusions. …

Juvenile Genetic Privacy In New York: Dna Collection And Maintenance Post-Francis O., Cassidy Moon

Cardozo Journal of Equal Rights & Social Justice

The note argues that the compulsory collection and indefinite maintenance of juvenile forensic DNA profiles violate the Fourth Amendment's protection against unreasonable searches and seizures. It asserts that such practices are particularly problematic for minors due to their heightened privacy interests, the low recidivism rates among juveniles, and the contradiction with the juvenile justice system's focus on rehabilitation and confidentiality. The note advocates for legislative reforms, such as New York Senate Bills 998 and 3104, to address these issues and protect juveniles' privacy rights.

Reciprocity And Beyond: Explaining Meat Transfers In Savanna-Dwelling Chimpanzees At Fongoli, Senegal, Angela M. Achorn, Stacy Lindshield, Papa Ibnou Ndiaye, Jeffrey Winking, Jill D. Pruetz

Anthropology Faculty Publications

Objectives

To understand the function of food sharing among our early hominin ancestors, we can turn to our nonhuman primate relatives for insight. Here, we examined the function of meat sharing by Fongoli chimpanzees, a community of western chimpanzees (Pan troglodytes verus) in southeastern Sénégal.

Materials and Methods

We tested three non-mutually exclusive hypotheses that have been used to explain patterns of food sharing: kin selection, generalized reciprocity, and meat-for-mating opportunities. We analyzed meat sharing events (n = 484) resulting from hunts, along with data on copulations, age-sex class, and kinship to determine which variables predict the …

Cloud Microphysical Response To Entrainment And Mixing Is Locally In Homogeneous And Globally Homogeneous: Evidence From The Lab, Jae Min Yeom, Ian Helman, Prasanth Prabhakaran, Jesse Anderson, Fan Yang, Raymond Shaw, Et. Al.

Michigan Tech Publications

Entrainment of dry air into clouds strongly influences cloud optical and precipitation properties and the response of clouds to aerosol perturbations. The response of cloud droplet size distributions to entrainment–mixing is examined in the Pi convection-cloud chamber that creates a turbulent, steady-state cloud. The experiments are conducted by injecting dry air with temperature (T_e) and flow rate (Q_e) through a flange in the top boundary, into the otherwise well-mixed cloud, to mimic the entrainment–mixing process. Due to the large-scale circulation, the downwind region is directly affected by entrained dry air, whereas the upwind region is representative …

Sepsis Exacerbates Alzheimer’S Disease Pathophysiology, Modulates The Gut Microbiome, Increases Neuroinflammation And Amyloid Burden, Vijayasree V Giridharan, Celso S G Catumbela, Carlos Henrique R Catalão, Juneyoung Lee, Bhanu P Ganesh, Fabricia Petronilho, Felipe Dal-Pizzol, Rodrigo Morales, Tatiana Barichello

Faculty, Staff and Student Publications

While our understanding of the molecular biology of Alzheimer's disease (AD) has grown, the etiology of the disease, especially the involvement of peripheral infection, remains a challenge. In this study, we hypothesize that peripheral infection represents a risk factor for AD pathology. To test our hypothesis, APP/PS1 mice underwent cecal ligation and puncture (CLP) surgery to develop a polymicrobial infection or non-CLP surgery. Mice were euthanized at 3, 30, and 120 days after surgery to evaluate the inflammatory mediators, glial cell markers, amyloid burden, gut microbiome, gut morphology, and short-chain fatty acids (SCFAs) levels. The novel object recognition (NOR) task …

Cellular Responses After (Neratinib Plus Pemetrexed) Exposure In Nsclc Cells, Laurence Booth, Andrew Poklepovic, John F Hancock, Paul Dent

Faculty, Staff and Student Publications

We previously demonstrated that neratinib interacted with pemetrexed to kill non-small cell lung cancer (NSCLC) cells. From developing other drug combinations, we observed that several days following exposure, cells activated survival mechanisms to counteract drug toxicity. The present studies attempted to define mechanisms that evolve to reduce the efficacy of neratinib and pemetrexed. Neratinib and pemetrexed synergized to kill NSCLC cells expressing wild-type RAS proteins, mutant KRAS (G12S; Q61H; G12A and G12C) or mutant NRAS (Q61K) or mutant ERBB1 (L858R; L858R T790M and exon 19 deletion). Neratinib and pemetrexed interacted in a greater than additive fashion to kill after 24 …

Religion And Atheism In Everyday Day Life Of The Ukrainian Educators In The 1920s-1930s, Oleksandr Lukyanenko, Vitaly Dmytrenko, Vita Dmytrenko

Occasional Papers on Religion in Eastern Europe

The article illustrates the process of formation of the atheist worldview of Soviet citizens under the pressure of Bolshevik propaganda in the context of student-teaching communities of higher educational institutions of the Ukrainian Soviet Socialist Republic. The study shows two poles of the life of teachers: the limit of involvement in the work in the societies of militant God-fighters and the marginal position of the believers with all the resulting negative consequences for the personality, which the atheistic totalitarian state tried to create for a person. Along with highlighting the state-wide patterns of the anti-religious struggle in the Ukrainian socialist …

Factors Associated With Periodontitis In Younger Individuals: A Scoping Review, Man Hung, Roah Kelly, Amir Mohajeri, Logan Reese, Sarah Badawi, Taroniar Sevathas, Cole Frost, Martin S. Lipsky

Institute on Aging Publications

Periodontitis is a disease that affects many young adults, and if left untreated, it can have lasting and permanent effects on an individual’s oral health. The purpose of this scoping review was to review the recent literature to identify factors that place young individuals at risk of stage II or III periodontitis. Using the PRISMA guidelines for scoping reviews, three databases were systematically searched for peer-reviewed human studies published in English that investigated risk factors associated with stage II and/or III periodontitis in individuals less than 40 years of age. This review excluded abstracts, literature reviews, including narrative, scoping, and …

The Advocate (Fall 2023), Lewis & Clark Law School

The Advocate

No abstract provided.

The Pacifican October 2023, University Of The Pacific

All Issues - Student Newspaper, The Pacifican, Pacific Weekly

No abstract provided.

Modeling And Analyzing The Influence Of Fear On The Harvested Modified Leslie-Gower Model, Abdul Rahman Mahmoud Jamil, Raid Kamel Naji

Baghdad Science Journal

A modified Leslie-Gower predator-prey model with a Beddington-DeAngelis functional response is proposed and studied. The purpose is to examine the effects of fear and quadratic fixed effort harvesting on the system's dynamic behavior. The model's qualitative properties, such as local equilibria stability, permanence, and global stability, are examined. The analysis of local bifurcation has been studied. It is discovered that the system experiences a saddle-node bifurcation at the survival equilibrium point whereas a transcritical bifurcation occurs at the boundary equilibrium point. Additionally established are the prerequisites for Hopf bifurcation existence. Finally, using MATLAB, a numerical investigation is conducted to verify …

Synthesis And Characterization Of Co-Polymer (Styrene / Allyl 2,3,4,6-Tetra-O-Acetyl-Β-D-Glucopyranoside) And Studying Some Of Its Thermal Properties, Yousef Wadouh, Rana Ghenem, Warda Khalil, Mohammad Keshe

Baghdad Science Journal

In this research, a Co-polymer (Styrene / Allyl-2.3.4.6-tetra-O-acetyl-β-D-glucopyranoside) was synthesized from glucose in four steps using Addition Polymerization according to the radical mechanism using Benzoyl Peroxide (BP) as initiator. Initially, Allyl-2.3.4.6-tetra-O-acetyl-β-D-glucopyranoside monomer was prepared in three steps and the reaction was followed by (HPLC, FT-IR, TLC), in the fourth step the monomer was polymerized with Styrene and the structure was determined by FT-IR and NMR spectroscopy. The reaction conditions (temperature, reaction time, material ratios) were also studied to obtain the highest yield, the relative, specific and reduced viscosity of the prepared polymer was determined, from which the viscosity average molecular …

Ghrelin And Obestatin Levels As A Novel Marker In Iraqi Obese Children, Noor Thair Tahir, Wafaa Raji Alfatlawi, Walaa Ahmed Al Jedda

Baghdad Science Journal

Obesity is an escalating health problem in developing countries. One to ten children worldwide are overweight in a report showed by the International Obesity Task Force. Ghrelin, orexigenic peptide, has 28 amino acids, it is considered the greatest remarkable promotion in the last two decades for understanding the physiological changes of action regu­lating food intake and hunger. Obestatin is a 23-amino acid peptide nearly connected to ghrelin that secures from substitution splicing the alike resort molecule, pre-proghrelin. The study is designed to assess the level of ghrelin and obestatin in Iraqi obese children and its relation with other biochemical parameters. …

Molecular Detection By Some Virulence Genes Of Salmonella Enterica Subsp. Enterica Isolated From The Stool Of Children With Diarrhea, Mohammed Nadhir Maaroof, Ahmed Hussein Dhayea

Baghdad Science Journal

Diarrhea is a real disease in childhood which could cause death. Therefore, this study was conducted to isolate Salmonella from 350 stool samples taken from children under five years in age, suffering from diarrhea during the period from March 2019 to March 2020 in Tikrit city / Iraq. The results showed the possibility to isolate ten isolates of Salmonella enterica subsp. Enterica, an infection rate, represents 2.875% of the total rate of patients who suffer from diarrhea. The virulence genes were investigated for ten isolates of S. enterica subsp. enterica, the result is that all isolates possessed the genes stn, …

Dynamics Of Predator-Prey Model Under Fluctuation Rescue Effect, Ghassan E. Arif, Jawdat Alebraheem, Warif B. Yahia

Baghdad Science Journal

This paper presents a novel idea as it investigates the rescue effect of the prey with fluctuation effect for the first time to propose a modified predator-prey model that forms a non-autonomous model. However, the approximation method is utilized to convert the non-autonomous model to an autonomous one by simplifying the mathematical analysis and following the dynamical behaviors. Some theoretical properties of the proposed autonomous model like the boundedness, stability, and Kolmogorov conditions are studied. This paper's analytical results demonstrate that the dynamic behaviors are globally stable and that the rescue effect improves the likelihood of coexistence compared to when …

Effects Of Water Stress, Nitrogen, Magnesium And Their Interactions On Some Growth Characteristics And Essential Oil Content Of Rosemary (Rosmarinus Officinalis L.), Nahla M. A. Khaleel, Abdulghany O. I. Sarmamy

Baghdad Science Journal

A factorial experiment was applied with four replicates on rosemary plants (Rosmarinus officinalis L.) grown in pots inside the glasshouse of the Department of Biology, College of Science, Salahaddin University, Erbil, Iraq, during April, 2019 to July, 2020, to determine the effects of soil moisture content ( SM1: 100% and SM2: 60% field capacity), nitrogen fertilizer (N1: 100, N2: 200 and N3: 300kg/hectare), and magnesium fertilizer (Mg1: 0.0, Mg2: 30 and Mg3: 60kg/hectare) and their interactions on some growth characteristics and essential oil content of rosemary plants. Two cuttings were taken from rosemary shoots (on March, 2020 and July, 2020) …

Green Synthesis Of Cds:Sn Nps By Starch As A Covering Agent And Studying Its Physical Properties, Zainab Yaaqoub, Nada K. Abbas

Baghdad Science Journal

The aim of this research is to employ starch as a stabilizing and reducing agent in the production of CdS nanoparticles with less environmental risk, easy scaling, stability, economical feasibility, and suitability for large-scale production. Nanoparticles of CdS have been successfully produced by employing starch as a reducing agent in a simple green synthesis technique and then doped with Sn in certain proportions (1%, 2%, 3%, 4%, and 5%).According to the XRD data, the samples were crystallized in a hexagonal pattern, because the average crystal size of pure CdS is 5.6nm and fluctuates in response to the changes in doping …

Biological Peculiarities Of Leucozonella Retteri, Zafar M. Makhmudjonov, Khayrullo B. Khakimov, Nilufar A. Mekhmonova, Shakhzoda R. Nasriddinova, Seytveli S. Abdurashitov

Baghdad Science Journal

The aim of the research is to study the biology, life cycles, distribution and structure of the reproductive organ of Leucozonella retteri in natural conditions. Zoological and malacological methods are used in the work. The collection of the material was carried out according to A.A. Shileiko method. According to the results of the conducted studies, the differences between Leucozonella retteri and other species in the structure of the reproductive organ were manifested in the following. The lower part of the sperm is straight, the ovary is slightly curved. The paw pad is 8, located in 4x2 positions. The stylophore is …

The Necessary And Sufficient Optimality Conditions For A System Of Focps With Caputo–Katugampola Derivatives, Moataz Abbas Holel, Sameer Qasim Hasan

Baghdad Science Journal

The necessary optimality conditions with Lagrange multipliers λ(t)∈Rn are studied and derived for a new class that includes the system of Caputo–Katugampola fractional derivatives to the optimal control problems with considering the end time free. The formula for the integral by parts has been proven for the left Caputo–Katugampola fractional derivative that contributes to the finding and deriving the necessary optimality conditions. Also, three special cases are obtained, including the study of the necessary optimality conditions when both the final time ���� and the final state x(����) are fixed. According to convexity assumptions prove that necessary optimality conditions are sufficient …

Estimation Of Apelin Levels In Iraqi Patients With Type Ii Diabetic Peripheral Neuropathy, Hadel Khalid Jaid, Fayhaa Muqdad Khaleel, Isam Noori Salman, Baydaa Ahmed Abd

Baghdad Science Journal

Diabetes mellitus type 2 (T2DM) is a chronic and progressive condition, which affects people all around the world. The risk of complications increases with age if the disease is not managed properly. Diabetic neuropathy is caused by excessive blood glucose and lipid levels, resulting in nerve damage. Apelin is a peptide hormone that is found in different human organs, including the central nervous system and adipose tissue. The aim of this study is to estimate Apelin levels in diabetes type 2 and Diabetic peripheral Neuropathy (DPN) Iraqi patients and show the extent of peripheral nerve damage. The current study included …

Synthesis And Characterization Of Grafted Chitosan Blending With Polyvinyl Alcohol / Nanocomposite And Study Biological Activity, Ruwaidah S. Saeed, Hanaa G. Attiya, Kawther Ayad Obead

Baghdad Science Journal

The study of biopolymers and their derivative materials had received a considerable degree of attention from researchers in the preparation of novel material. Biopolymers and their derivatives have a wide range of applications as a result of their bio-compatibility, bio-degradability and non-toxicity. In this paper, chitosan reacted with different aldehydes(2,4 –dichloro- benzaldehyde or 2-methyl benzaldehyde), different ketones (4-bromoacetophenone or 3-aminoacetophenone) to produce chitosan schiff base (1-4) . Chitosan schiff base (1-4) reacted with glutaric acid or adipic acid in acidic media in distilled water according to the steps of Fischer and Speier to produce compounds (5-12) respectively. Grafted chitosan (5-12) …

Pursuing Culturally Responsive Math Teaching By Secondary Math Educators: A Professional Development Action Research Study, Emily Bell Redding

Theses and Dissertations

This action research study examines the use of professional development to build the self-efficacy of secondary math teachers in culturally responsive mathematics teaching (CRMT), with the hope to address achievement gaps of Black and Hispanic students. Seven math teachers from a school division in Southwest Virginia participated in a 9-week professional development that included virtual meetings to learn about CRMT, collaboration with colleagues, classroom applications, and self-reflection. Quantitative and qualitative data were collected throughout the 9 weeks in the forms of questionnaires, meeting transcripts, and reflection journals. The research study results found the professional development to build teacher self-efficacy, especially …

Infection Intensity And Prevalence From Perkinsus Marinus In The Eastern Oyster, Crassostrea Virginica (Gmelin 1791) And Their Association With Salinity, Temperature, And Sex In South Carolina Estuaries, Deja E. Best

Theses and Dissertations

This project aimed to identify the associations between the infection intensity and prevalence of Perkinsus marinus infection (i.e., Dermo ) in the Eastern oyster, Crassostrea virginica (Gmelin), with extrinsic environmental factors such as changes in salinity and temperature along with oyster host factors such as sex ratio. The objectives of the study were to: (1) identify significant associations between the dependent variables, P. marinus prevalence and infection intensity, in relation to salinity and water temperature which may be affected by climate change; and (2) identify any intrinsic factors related to sex (i.e., male, female, intersex, and indeterminant) that may affect …

Replenishment Of Essential Natural Resources: An Assessment Of The Ability Of Freshwater Algae To Enhance Crop Quality And Soil Health, Lala Christina Ek

Theses and Dissertations

Disregard for soil, an essential natural resource, hinders global food production. Food insecurity is a major concern for both public health officials and environmental scientists due to soil quality decline, pollution, and climate change. Alternatives or targeted additions to chemical fertilizers can bolster soil quality, improve crop yields, lengthen crop shelf life, and mitigate environmental pollution. One potential alternative to chemical fertilizers is replacement of them with biological soil amendments, including algae, to enhance crop growth and improve soil health. Research was conducted at the University of South Carolina-Columbia campus garden to determine impacts of non-toxic freshwater algae on crop …

Structure V-1: A Mississippian Mica Workshop In Kershaw County, South Carolina, John Mclellan Dodge

Theses and Dissertations

This thesis reanalyzes the pottery assemblage of Structure V-1 at the Mulberry site (38KE12). Because Structure V-1 was originally hypothesized to be evidence of a late seventeenth century occupation at the Mulberry site, the framework I use for this research focuses on identifying evidence of community coalescence after Mulberry’s initial occupation ended. However, new evidence from both the pottery and radiocarbon analysis conclusively dates the structure to around the sixteenth century Mulberry I phase. With that new date in mind, I explore the role mica craft production within Structure V-1 might have had in linking the community at Mulberry to …