Digital Commons Network^™

Narrowing The Divide: Posthuman Autopoiesis And Social Propaganda, Alexandra Holmes

International Journal of Undergraduate Research and Creative Activities

This paper examines the relationship between social propaganda as presented by Jacques Ellul in his book Propaganda: the Formation of Men’s Attitudes and the concept of autopoiesis (or self-generation) within posthuman ideology. These two concepts intersect in their connection of the individual to the masses. Both posthuman theory and Ellul’s concept of social interaction are based on the bridging of the ontological gap to overcome cognitive isolation, resulting in the engagement in a community outside of oneself. The stripping of individuality becomes necessary, as our self-contained autopoietic beings employ analogical inference in order to connect with the mass, and therefore …

The Discourse Of The Scalpel And The Limbo Of Non-Identity: Doing Justice To Herculine Barbin, Aurora Laybourn-Candlish

International Journal of Undergraduate Research and Creative Activities

In this essay I will make a comparative analysis of Butlers reading of Herculin Barbin in Gender Trouble and David Reimer in Undoing Gender. My reading of Undoing Gender will illustrate reflective moments in which Butler herself describes spaces outside of intelligibility. First, my analysis will consist of in reading Butlers earlier work against her more recent writings on gender. Utilizing the same critical lens that Butler incorporated to compare Foucault’s later work against his earlier writing will bring to the fore important tensions in Bulter’s gender theory and her relationship with Foucault. Second, I will describe the discourse of …

Semantics Embodied: Cognitive Linguistics And Searle’S Account Of Linguistic Intentionality, Krivo Flores

International Journal of Undergraduate Research and Creative Activities

John Searle has long argued that the philosophy of language is a branch of the philosophy of mind. In his view the capacity of speech acts to represent and relate to reality derives from more biologically basic forms of intentionality, such as perception and action, which initially evolved to relate organisms directly to their environments. Searle’s naturalistic model of language, in order to be complete, requires a theory of how perception and action specifically give rise to linguistic meaning and interpretation. In this paper I argue that recent theoretical developments in cognitive linguistics and the emerging field of embodied cognition …

Juxtaposing Longino’S “Equality Of Intellectual Authority” With Her “Shared Standards”, Gourav Krishna Nandi

International Journal of Undergraduate Research and Creative Activities

Helen Longino has proposed four criteria that can objectively criticize the background beliefs and assumptions in the development of scientific theories. She deduces that the criteria - ‘recognized avenues for criticism,’ ‘shared standards,’ ‘community response’ and ‘equality of intellectual authority’ - are mutually dependent. Using the assumption that the acceptance of more than one scientific approach is possible only if an individual is educated in a non-standard background, and is given intellectual authority which, in turn, refutes the idea of standardization in science, I argue that her assertion is contradictory. One of her criterion ‘shared standards’ implicitly nullifies the attempt …

Sex Differences In Stress Reactivity And Responses To Novelty In The Gray Short-Tailed Opossum (Monodelphis Domestica), Esperanza I. Alaniz, Nicole Altamirano, Joseph Rafac, Katelynn Renteria, John L. Vandeberg, Mario Gil

Research Colloquium

Introduction: Investigating how exposures to stress and novel environments influence behavior is important for translational research that aims to improve mental health. Previous studies have focused on reactions to novelty and revealed changes in defense reactions and exploratory behavior. (Pisula et al., 2012).

Objective: The focus of the present study is to investigate sex differences in behavioral responses to novel environments and restraint stress in the gray short-tailed opossums (Monodelphis domestica). Using the Monodelphis is innovative because it is a non-traditional animal model that is ideal for developmental research.

Methods: Using AnyMaze video tracking software, animals’ behaviors (6 males, 6 …

Plasmid Midiprep: A Method To Purify Plasmids For Recombinant Dna Studies, Adithya Anilkumar, Kyle Doxtater, Samantha Lopez, Sudhir Kotnala, Justin Wendel, Manish Tripathi

Research Colloquium

A fundamental aspect of molecular biology involves exploring the properties and functions of specific genes. The rise of recombinant DNA technology has vastly improved and simplified functional studies by allowing scientists to isolate specific genes using restriction enzymes and plasmids providing greater precision. Plasmids take great significance in downstream studies, which is why quantity and quality of the plasmids purified is important. In this study, we isolated and purified recombinant plasmids in microgram quantities to confirm the yield, quantity, and quality using spectral and size fractionation methods. We also assessed the plasmids for application in downstream studies. We found the …

Spartan Daily, October 11, 2023, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2023

Volume 161, Issue 22

We Are ... Marshall, October 11, 2023, Office Of Marshall University Communications

We Are ... Marshall: the Newsletter for Marshall University 1999-2023

No abstract provided.

2023 October 11 - Undergraduate Curriculum Council Minutes, Undergraduate Curriculum Council, East Tennessee State University

Undergraduate Curriculum Council Minutes

No abstract provided.

Insights Into The Molecular Roles Of Foxr2 In The Pathology Of Primary Pediatric Brain Tumors, Rajendra Gharbaran

Publications and Research

Forkhead box gene R2 (FOXR2) belongs to the family of FOX genes which codes for highly conserved transcription factors (TFs) with critical roles in biological processes ranging from development to organogenesis to metabolic and immune regulation to cellular homeostasis. A number of FOX genes are associated with cancer development and progression and poor prognosis. A growing body of evidence suggests that FOXR2 is an oncogene. Studies suggested important roles for FOXR2 in cancer cell growth, metastasis, and drug resistance. Recent studies showed that FOXR2 is overexpressed by a subset of newly identified entities of embryonal tumors. This review discusses the …

University Philharmonic Orchestra & University Band

Bailey School of Music Concert Programs

Program for October 11, 2023.

The Unspoken Obvious: There Are Queer Children, Willie Edward Taylor Carver Jr.

Justice Festival at Morehead State University

A PowerPoint presentation, titled "The Unspoken Obvious: There are Queer Children," given by Willie Edward Taylor Carver Jr. at the Justice Festival held on the campus of Morehead State University on October 11, 2023.

2023-10-11 Julieta Peralta: Finding Dreams Beyond The Lines, Kevin Ruiz

The Spectator Online

No abstract provided.

A Proof-Of-Concept Pilot Test Of A Behavioral Intervention To Improve Adherence To Dietary Recommendations For Cancer Prevention, Meghan Butryn, Charlotte Hagerman, Nicole Crane, Marny Ehmann, Evan Forman, Brandy-Joe Milliron, Nicole L. Simone

Department of Radiation Oncology Faculty Papers

OBJECTIVES: Prevention programs that can help adults improve the quality of their diets to reduce cancer risk are needed. This Phase IIa study prospectively tested a mHealth intervention designed to improve adherence to dietary quality guidelines for cancer prevention.

METHODS: All participants (N = 62) received nutrition education and a self-regulation skills curriculum, with a primary target of changing grocery shopping behavior. Using a randomized, factorial design, the study varied whether each of the following 4 components were added to the 20-week intervention: (1) location-triggered app messaging, delivered when individuals arrived at grocery stores, (2) reflections on benefits of change, …

Nrg/Rtog 0837: Randomized, Phase Ii, Double-Blind, Placebo-Controlled Trial Of Chemoradiation With Or Without Cediranib In Newly Diagnosed Glioblastoma, Tracy T. Batchelor, Minhee Won, Arnab Chakravarti, Costas G. Hadjipanayis, Wenyin Shi, Lynn S. Ashby, Volker W. Stieber, H. Ian Robins, Heidi J. Gray, Alfredo Voloschin, John B. Fiveash, Clifford G. Robinson, Ushasree Chamarthy, Young Kwok, Terrence P. Cescon, Anand K. Sharma, Rekha Chaudhary, Mei-Yin Polley, Minesh P. Mehta

Department of Radiation Oncology Faculty Papers

BACKGROUND: A randomized, phase II, placebo-controlled, and blinded clinical trial (NCT01062425) was conducted to determine the efficacy of cediranib, an oral pan-vascular endothelial growth factor receptor tyrosine kinase inhibitor, versus placebo in combination with radiation and temozolomide in newly diagnosed glioblastoma.

METHODS: Patients with newly diagnosed glioblastoma were randomly assigned 2:1 to receive (1) cediranib (20 mg) in combination with radiation and temozolomide; (2) placebo in combination with radiation and temozolomide. The primary endpoint was 6-month progression-free survival (PFS) based on blinded, independent radiographic assessment of postcontrast T1-weighted and noncontrast T2-weighted MRI brain scans and was tested using a 1-sided …

The Inherited Kras-Variant As A Biomarker Of Cetuximab Response In Nsclc, Joanne Weidhaas, Chen Hu, Ritsuko Komaki, Gregory Masters, George Blumenschein, Joe Chang, Bo Lu, Adam Dicker, Jeffrey Bogart, Yolanda Garces, Samir Narayan, Clifford Robinson, Vivek Kavadi, Joel S Greenberger, Christopher Koprowski, James Welsh, Elizabeth Gore, Robert Macrae, Rebecca Paulus, Jeffrey Bradley

Department of Radiation Oncology Faculty Papers

PURPOSE: RTOG 0617 was a phase III randomized trial for patients with unresectable stage IIIA/IIIB non-small cell lung cancer comparing standard-dose (60 Gy) versus high-dose (74 Gy) radiotherapy and chemotherapy, plus or minus cetuximab. Although the study was negative, based on prior evidence that patients with the KRAS-variant, an inherited germline mutation, benefit from cetuximab, we evaluated KRAS-variant patients in RTOG 0617.

EXPERIMENTAL DESIGN: From RTOG 0617, 328 of 496 (66%) of patients were included in this analysis. For time-to-event outcomes, stratified log-rank tests and multivariable Cox regression models were used. For binary outcomes, Cochran-Mantel-Haenzel tests and multivariable logistic regression …

Editorial For "Automated Breast Density Assessment In Mri Using Deep Learning And Radiomics: Strategies For Reducing Inter-Observer Variability"., Pegah Khosravi

Publications and Research

No abstract provided.

Chapter I — On Theories Of Modernization, Messay Kebede

Ethiopian Modernization: Opportunities and Derailments

The vast literature pertaining to development and modernity discloses philosophical questions that instigate the controversies dividing the various theories of modernization. Of these philosophical issues, the most crucial and recurrent is the question of the prime factor or mover of modernization. The reason for the philosophical issue of primacy derives from the fact that modernization involves cultural as well as socioeconomic changes. Following the philosophical distinction between the spiritual and the material, the clash between the two basic schools of idealism and materialism frames the philosophical approach around the question of knowing whether the prime cause of modernization is cultural …

Office Of Research, Economic Engagement And Outreach Update, October 11, 2023, Office Of Research, Economic Engagement And Outreach

Office of Research, Economic Engagement and Outreach

No abstract provided.

Updates In Sjs/Ten: Collaboration, Innovation, And Community., Madeline E. Marks, Ramya Krishna Botta, Riichiro Abe, Thomas M. Beachkofsky, Isabelle Boothman, Bruce C. Carleton, Wen-Hung Chung, Ricardo R. Cibotti, Roni P Dodiuk-Gad, Christian Grimstein, Akito Hasegawa, Jay H. Hoofnagle, Shuen-Iu Hung, Benjamin Kaffenberger, Daniela Kroshinsky, Rannakoe J. Lehloenya, Michelle Martin-Pozo, Robert G. Micheletti, Maja Mockenhaupt, Keisuke Nagao, Suman Pakala, Amy Palubinsky, Helena B. Pasieka, Jonathan Peter, Munir Pirmohamed, Melissa Reyes, Hajirah N. Saeed, Jeffery Shupp, Chonlaphat Sukasem, Jhih Yu Syu, Mayumi Ueta, Li Zhou, Wan-Chun Chang, Patrice Becker, Teresa Bellon, Kemberlee Bonnet, Gianpiero Cavalleri, James Chodosh, Anna K. Dewan, Arturo Dominguez, Xinzhong Dong, Elena Ezhkova, Esther Fuchs, Jennifer Goldman, Sonia Himed, Simon Mallal, Alina Markova, Kerry Mccawley, Allison E. Norton, David Ostrov, Michael Phan, Arthur Sanford, David Schlundt, Daniel Schneider, Neil Shear, Kanade Shinkai, Eric Tkaczyk, Jason A. Trubiano, Simona Volpi, Charles S. Bouchard, Sherrie J. Divito, Elizabeth J. Phillips

Manuscripts, Articles, Book Chapters and Other Papers

Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis (SJS/TEN) is a predominantly drug-induced disease, with a mortality rate of 15-20%, that engages the expertise of multiple disciplines: dermatology, allergy, immunology, clinical pharmacology, burn surgery, ophthalmology, urogynecology, and psychiatry. SJS/TEN has an incidence of 1-5/million persons per year in the United States, with even higher rates globally. One of the challenges of SJS/TEN has been developing the research infrastructure and coordination to answer questions capable of transforming clinical care and leading to improved patient outcomes. SJS/TEN 2021, the third research meeting of its kind, was held as a virtual meeting on August 28-29, 2021. The …

The Inherited Kras-Variant As A Biomarker Of Cetuximab Response In Nsclc, Joanne B Weidhaas, Clifford G Robinson, Et Al.

2020-Current year OA Pubs

PURPOSE: RTOG 0617 was a phase III randomized trial for patients with unresectable stage IIIA/IIIB non-small cell lung cancer comparing standard-dose (60 Gy) versus high-dose (74 Gy) radiotherapy and chemotherapy, plus or minus cetuximab. Although the study was negative, based on prior evidence that patients with the KRAS-variant, an inherited germline mutation, benefit from cetuximab, we evaluated KRAS-variant patients in RTOG 0617.

EXPERIMENTAL DESIGN: From RTOG 0617, 328 of 496 (66%) of patients were included in this analysis. For time-to-event outcomes, stratified log-rank tests and multivariable Cox regression models were used. For binary outcomes, Cochran-Mantel-Haenzel tests and multivariable logistic regression …

Redshift Wrangler: Conducting A Citizen Science Study Of Extragalactic Spectroscopy, Sadie C. Coffin

Theses

I present the citizen science project Redshift Wrangler, designed to use the contributions of volunteers to analyze large samples of galaxy data and build a repository of spectroscopic measurements for various analyses. When we know how to read it, the spectrum of a galaxy can tell the story of its stellar population, distance, and interactions with any close companion galaxies. Through Redshift Wrangler, citizen science measurements become our main tool for extracting information from enormous quantities of collected spectra. Several main goals motivate this work: first, designing and launching Redshift Wrangler on citizen science platform Zooniverse to bring more people …

The Parthenon, October 11, 2023, Evan Green, Conner Woodruff, Matt Schaffer, Chayce Matheny, Victoria Ware, Shauntelle Thompson, Rafael Alfonso, Scott Price

The Parthenon

No abstract provided.

Neuronal Nadph Oxidase Is Required For Neurite Regeneration Of Aplysia Bag Cell Neurons, S.M. Sabbir Alam, Yuichiro Watanabe, Brooke L. Steeno, Soumyajit Dutta, Halie A. Szilagyi, Alexander Wei, Daniel M. Suter

Department of Chemistry Faculty Publications

NADPH oxidase (Nox), a major source of reactive oxygen species (ROS), is involved in neurodegeneration after injury and disease. Nox is expressed in both neuronal and non-neuronal cells and contributes to an elevated ROS level after injury. Contrary to the well-known damaging effect of Nox-derived ROS in neurodegeneration, recently a physiological role of Nox in nervous system development including neurogenesis, neuronal polarity, and axonal growth has been revealed. Here, we tested a role for neuronal Nox in neurite regeneration following mechanical transection in cultured Aplysia bag cell neurons. Using a novel hydrogen peroxide (H2O2)-sensing dye, 5′-(p-borophenyl)-2′-pyridylthiazole pinacol ester (BPPT), we …

Bill Bargeman Oral History, Bill Bargeman, Lorenzo Spaccarelli

Raymond College

No abstract provided.

Blood Biomarker-Based Classification Study For Neurodegenerative Diseases, Jack Kelly, Rana Moyeed, Camille Carroll, Shouqing Luo, Xinzhong Li

Peninsula Medical School

As the population ages, neurodegenerative diseases are becoming more prevalent, making it crucial to comprehend the underlying disease mechanisms and identify biomarkers to allow for early diagnosis and effective screening for clinical trials. Thanks to advancements in gene expression profiling, it is now possible to search for disease biomarkers on an unprecedented scale.Here we applied a selection of five machine learning (ML) approaches to identify blood-based biomarkers for Alzheimer's (AD) and Parkinson's disease (PD) with the application of multiple feature selection methods. Based on ROC AUC performance, one optimal random forest (RF) model was discovered for AD with 159 gene …

Usp1 Promotes Cholangiocarcinoma Progression By Deubiquitinating Parp1 To Prevent Its Proteasomal Degradation, Deng Yong Zhang, Yan Zhu, Qiong Wu, Shuoshuo Ma, Yang Ma, Zheng Chao Shen, Zhonglin Wang, Wanliang Sun, Yong Chun Zhou, Dongdong Wang, Shuo Zhou, Zhong Liu, Lawrence N Kwong, Zheng Lu

Faculty, Staff and Student Publications

Despite its involvement in various cancers, the function of the deubiquitinase USP1 (ubiquitin-specific protease 1) is unexplored in cholangiocarcinoma (CCA). In this study, we provide evidence that USP1 promotes CCA progression through the stabilization of Poly (ADP-ribose) polymerase 1 (PARP1), consistent with the observation that both USP1 and PARP1 are upregulated in human CCA. Proteomics and ubiquitylome analysis of USP1-overexpressing CCA cells nominated PARP1 as a top USP1 substrate. Indeed, their direct interaction was validated by a series of immunofluorescence, co-immunoprecipitation (CO-IP), and GST pull-down assays, and their interaction regions were identified using deletion mutants. Mechanistically, USP1 removes the ubiquitin …

The Effects Of Immediate Static Stretching On Exercise Induced Inflammation And Doms Following An Acute Bout Of Eccentric Exercise Of The Triceps, Valarie R. Dimartino

Seton Hall University Dissertations and Theses (ETDs)

Introduction: Delayed onset muscle soreness (DOMS) is caused by the body's immune system attempting to heal damaged muscles, creating exercise induced inflammation. DOMS impacts exercise performance and adherence. Treatments provide temporary relief yet fail to inhibit the mechanism of inflammation. Purpose: The purpose of this quantitative investigation was to explore the effect of immediate static stretching on the inflammatory response and subsequent DOMS following an acute bout of eccentric triceps dips. Inflammation was measured via triceps girth (cm) and self-reported Visual Analog Scale (VAS) ratings of DOMS. Methods: 24 healthy adult participants (27.4 ± 7.5 yrs., 80 ± …

Nrg/Rtog 0837: Randomized, Phase Ii, Double-Blind, Placebo-Controlled Trial Of Chemoradiation With Or Without Cediranib In Newly Diagnosed Glioblastoma, Minesh Mehta

All Publications

Background: A randomized, phase II, placebo-controlled, and blinded clinical trial (NCT01062425) was conducted to determine the efficacy of cediranib, an oral pan-vascular endothelial growth factor receptor tyrosine kinase inhibitor, versus placebo in combination with radiation and temozolomide in newly diagnosed glioblastoma.

Methods: Patients with newly diagnosed glioblastoma were randomly assigned 2:1 to receive (1) cediranib (20 mg) in combination with radiation and temozolomide; (2) placebo in combination with radiation and temozolomide. The primary endpoint was 6-month progression-free survival (PFS) based on blinded, independent radiographic assessment of postcontrast T1-weighted and noncontrast T2-weighted MRI brain scans and was tested using …

Exploring Low-Income, Black Fathers' Strengths And Barriers To Positive Change Using Qualitative Methods, Katie N. Russell, Ashley Withrow, Laura A. Voith, Carmen Vernon, Hyunjune Lee, Sherise Mckinney

Faculty Scholarship

Objective: The goal was to explore low-income, Black fathers' personal strengths and barriers to engaged fatherhood, healthy relationships, and economic stability. Background: Fatherhood programs often rely on case management and education to promote positive fathering, healthy relationships, and economic stability. However, methods should be tailored to fit the strengths and needs of participating fathers. Low-income, Black fathers face additional challenges related to systemic discrimination and structural violence that can hinder their success. To effectively serve this group, research is required to understand their relevant strengths and barriers. Methods: Semistructured focus groups explored fathers' personal strengths and barriers specific to the …