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Impact Of Type 2 Diabetes Mellitus On Quality Of Life In People With Diabetespresenting To A Specialist Diabetes Clinic, Bilal Bin Younis, Rozina Arshad, Haroon Yousuf, Fatima Salman, Junaid Masood, Saima Khurshid Jan 2017

Impact Of Type 2 Diabetes Mellitus On Quality Of Life In People With Diabetespresenting To A Specialist Diabetes Clinic, Bilal Bin Younis, Rozina Arshad, Haroon Yousuf, Fatima Salman, Junaid Masood, Saima Khurshid

Turkish Journal of Medical Sciences

Background/aim: Quality of life is an important health-related factor that has an impact on all health interventions. The aim of the study was to assess psychosocial outcomes in people with diabetes Materials and methods: A total of 142 people with type 2 diabetes were recruited from a specialist diabetes center. The validated Urdu version of the WHO-5 Well-Being Index was administered for easy understanding of the quality of life of the regional population. Results: The 142 adult participants with diabetes were recruited from a specialist diabetes clinic. The rate of likely depression (WHO-5 score of <28) was 16.9%. Neuropathy was found to have a negative impact on the quality of life in people with diabetes (P 6lt; 0.001). Conclusion: People with complications of diabetes like neuropathy may experience worsening quality of life. It is advised to incorporate the WHO-5 into annual patient reviews as a measure of emotional well-being to drive changes that improve outcomes for people with diabetes.


The Comparison Of Various Disinfectants? Efficacy On Staphylococcus Aureus And Pseudomonas Aeruginosa Biofilm Layers, Hati̇ce Köse, Nur Yapar Jan 2017

The Comparison Of Various Disinfectants? Efficacy On Staphylococcus Aureus And Pseudomonas Aeruginosa Biofilm Layers, Hati̇ce Köse, Nur Yapar

Turkish Journal of Medical Sciences

Background/aim: Because biofilms are resistant to antibiotics and biocides, they usually cause chronic persistent infections, which are arduous to cure and have high mortality and morbidity. Our study aimed to investigate the efficiency of orthophthalaldehyde, peracetic acid, hydrogen peroxide, and sodium hypochlorite on Pseudomonas aeruginosa and Staphylococcus aureus biofilm layers and live microbial cells. Materials and methods: Biofilm layers were determined by crystal violet assay and live microbial cells were determined using a resazurin assay. Results: For Pseudomonas aeruginosa, sodium hypochlorite showed the most influential disinfection because it diminished 83.6% of the biofilm layer and decreased 99.7% of live microbial …


Abdominal Actinomycosis In The Last 10 Years And Risk Factors For Appendiceal Actinomycosis: Review Of The Literature, Marta Lisa-Gracia, Berta Martín-Rivas, Marcos Pajaron-Guerrero, Ana Arnaiz-García Jan 2017

Abdominal Actinomycosis In The Last 10 Years And Risk Factors For Appendiceal Actinomycosis: Review Of The Literature, Marta Lisa-Gracia, Berta Martín-Rivas, Marcos Pajaron-Guerrero, Ana Arnaiz-García

Turkish Journal of Medical Sciences

Background/aim: Actinomycosis is a granulomatous disease caused by filamentous, gram-positive, anaerobic bacteria. Actinomycetes are commensal inhabitants of the oral cavity and intestinal tract but acquire pathogenicity through invasion of breached or necrotic tissue. In abdominal actinomycosis (AA), the appendix and ileocecal region are usually involved. The aim of this study was to characterize patients diagnosed with AA and to establish the risk factors for appendiceal actinomycosis, including a short review of the literature. Materials and methods: We conducted a prospective cohort study of all patients diagnosed with AA in the University Hospital Marques de Valdecilla (Santander-Cantabria) from January 2003 to …


Chromosomal Findings And Sequence Analysis Of Target Exons Of Calcium-Sensingreceptor (Casr) Gene In Patients With Sagliker Syndrome, Erdal Tunç, Osman Demi̇rhan, Yahya Sağliker, İsmai̇l Yildiz, Nuray Paylar, Ali̇ İrfan Güzel Jan 2017

Chromosomal Findings And Sequence Analysis Of Target Exons Of Calcium-Sensingreceptor (Casr) Gene In Patients With Sagliker Syndrome, Erdal Tunç, Osman Demi̇rhan, Yahya Sağliker, İsmai̇l Yildiz, Nuray Paylar, Ali̇ İrfan Güzel

Turkish Journal of Medical Sciences

Background/aim: Sagliker syndrome (SS) develops as a continuation of chronic kidney disease and secondary hyperparathyroidism conditions. It was thought that there are some genetic predisposition factors leading to SS. The calcium-sensing receptor (CaSR) is essential for calcium homeostasis in the body. We aimed to examine SS patients for chromosome aberrations (CAs) and CaSR gene abnormalities in exons 2 and 3. Materials and methods: Twenty-three patients and 23 control subjects were admitted to Balcalı Hospital of the Medical Faculty of Çukurova University in Turkey between 2009 and 2011. Chromosomal analysis was performed according to standard cytogenetic methods. Full sequencing of exons …


Primary Sjögren's Syndrome In Patients With Celiac Disease, Funda Erbasan, Deni̇z Turgut Çoban, Uğur Karasu, Yeşi̇m Çeki̇n, Bayram Yeşi̇l, Ayhan Hi̇lmi̇ Çeki̇n, Di̇nç Süren, Mustafa Ender Terzi̇oğlu Jan 2017

Primary Sjögren's Syndrome In Patients With Celiac Disease, Funda Erbasan, Deni̇z Turgut Çoban, Uğur Karasu, Yeşi̇m Çeki̇n, Bayram Yeşi̇l, Ayhan Hi̇lmi̇ Çeki̇n, Di̇nç Süren, Mustafa Ender Terzi̇oğlu

Turkish Journal of Medical Sciences

Background/aim: Many autoimmune diseases occur concomitantly with celiac disease (CD). We aimed to determine the frequency of Sjögren's syndrome (SS) in CD patients based on SS-specific serology verified by minor labial salivary biopsy. Materials and methods: Eight-two patients with CD were included in the study. After examination for objective evidence of sicca complex, all patients were tested for serological presence of rheumatoid factor (RF) and antinuclear antibodies (ANAs) and for ANA profile. Minor labial salivary biopsy was performed for patients with positive serology and/or clinical signs of SS. Results: Of the patients included, 24 (29.3%) had dry eye symptoms while …


Oral Lichen Planus: A 4-Year Clinical Follow-Up Study, Arunas Rimkevicius, Jolanta Aleksejuniene, Alina Puriene, Dmitrij Seinin, Ruta Rasteniene Jan 2017

Oral Lichen Planus: A 4-Year Clinical Follow-Up Study, Arunas Rimkevicius, Jolanta Aleksejuniene, Alina Puriene, Dmitrij Seinin, Ruta Rasteniene

Turkish Journal of Medical Sciences

Background/aim: This study aimed to examine oral lichen planus (OLP) cases histopathologically and cytologically, describe different clinical aspects of OLP manifestations, and associate different OLP clinical forms with self-reported oral health and with local and systemic risk factors. Materials and methods: All patients with a referral diagnosis of OLP received biopsies. The histological evaluation assessed infiltration with lymphocytes, epithelial hyperplasia, and hyperkeratosis. Histology was used to validate the OLP diagnosis and to evaluate the malignant transformation of OLP lesions. Clinical manifestations of OLP and potential local oral environment-related risks were clinically assessed. Systemic risks were evaluated by a structured questionnaire. …


Effects Of Ankaferd Bloodstopper On Dermal Healing In Diabetic Rats, Sertaç Aktop, Burcu Çevreli̇, Deni̇z Genç, Emel Serdaroğlu Kaşikçi, Ni̇l Çomunoğlu Üstündağ, Noushi̇n Zi̇bandeh, Eli̇f Merve Özcan, Gökhan Göçmen, Mehmet Kami̇l Göker, İsmai̇l Tayfun Uzbay, Tunç Akkoç Jan 2017

Effects Of Ankaferd Bloodstopper On Dermal Healing In Diabetic Rats, Sertaç Aktop, Burcu Çevreli̇, Deni̇z Genç, Emel Serdaroğlu Kaşikçi, Ni̇l Çomunoğlu Üstündağ, Noushi̇n Zi̇bandeh, Eli̇f Merve Özcan, Gökhan Göçmen, Mehmet Kami̇l Göker, İsmai̇l Tayfun Uzbay, Tunç Akkoç

Turkish Journal of Medical Sciences

Background/aim: Diabetes mellitus inhibits wound-induced angiogenesis, impairs the wound healing process, and leads to the development of chronic wounds. Ankaferd BloodStopper (ABS) is a new and promising local haemostatic agent. Although the mechanism of ABS-mediated haemostasis is well established, little is known about the associated histological and biochemical tissue reactions. The aim of this study was to evaluate the effects of this new-generation local haemostatic agent on short-term soft-tissue healing in streptozotocin (STZ)-treated rats. Materials and methods: The 24 Wistar albino rats used in this study were divided into STZ-treated (STZ, n = 12) and nontreated groups (control, n = …


Adults With Common Variable Immunodeficiency: A Singlecenter Experience, Uğur Haci̇ Muşabak, Fevzi̇ Demi̇rel, Sai̇t Yeşi̇lli̇k, Abdullah Baysan, Ali̇ Selçuk, Özgür Kartal, Mustafa Güleç, Çağatay Öktenli̇, Osman Şener Jan 2017

Adults With Common Variable Immunodeficiency: A Singlecenter Experience, Uğur Haci̇ Muşabak, Fevzi̇ Demi̇rel, Sai̇t Yeşi̇lli̇k, Abdullah Baysan, Ali̇ Selçuk, Özgür Kartal, Mustafa Güleç, Çağatay Öktenli̇, Osman Şener

Turkish Journal of Medical Sciences

Background/aim: In this study, we aimed to assess the clinical and immunological findings of our patients with common variable immunodeficiency (CVID). Materials and methods: We analyzed the records of 31 adult patients with CVID (12 females, 19 males). The patients were classified into clinical and immunophenotypic subgroups for statistical comparisons. Results: Our patients had some clinical signs in considerable frequencies, such as low body weight (45.2%), urinary tract infections (41.9%), various dermatoses (35.5%), and oral aphthae (32.3%). The histological findings in the biopsy specimens of the gastrointestinal tract (nodular lymphoid hyperplasia, villous atrophy, and lymphocytic infiltrates at mucosa) were significantly …


Evaluation Of Dental Technician's Pneumoconiosis Using Chest X-Rayand Hrct: Correlation Between Radiological And Functional Findings, Recai̇ Ergün, Di̇lek Ergün, Ender Evci̇k, Begüm Ergan Jan 2017

Evaluation Of Dental Technician's Pneumoconiosis Using Chest X-Rayand Hrct: Correlation Between Radiological And Functional Findings, Recai̇ Ergün, Di̇lek Ergün, Ender Evci̇k, Begüm Ergan

Turkish Journal of Medical Sciences

Background/aim: This study aimed to compare high-resolution computed tomography (HRCT) findings with those of chest X-ray (CXR) and to evaluate the relationship of pulmonary function test (PFT) parameters with HRCT and CXR findings in cases of dental technician's pneumoconiosis. Materials and methods: CXR, PFT, and HRCT data of 89 dental technicians who were diagnosed with pneumoconiosis were retrospectively evaluated. Results: The cases of 24 dental technicians (27%) classified as normal (Category 0) based on CXR were evaluated as Category 1 according to HRCT. There was an inverse correlation of PFT parameters with nodular profusion score in CXR and all HRCT …


Male Infertility Is Significantly Associated With Multiple Deletions In An 8.7-Kb Segment Of Sperm Mtdna In Pakistan, Irfan Afzal Mughal, Asma Irfan, Sarwat Jahan, Abdul Hameed Jan 2017

Male Infertility Is Significantly Associated With Multiple Deletions In An 8.7-Kb Segment Of Sperm Mtdna In Pakistan, Irfan Afzal Mughal, Asma Irfan, Sarwat Jahan, Abdul Hameed

Turkish Journal of Medical Sciences

Background/aim: This study aimed to find a link between sperm mitochondrial DNA mutations and male infertility in Pakistan. Materials and methods: DNA from semen samples was extracted and amplified by PCR using 7.8-kb deletion-specific primers. The PCR products were separated on agarose gel, visualized under UV-illumination, and then photographed. The results were genotyped and the data were analyzed using SPSS. Results: Deletion analysis of the 8.7-kb fragment by long PCR revealed multiple deletions. The frequency of deletion was much higher in infertile groups as compared to the control group. Further, on comparison between different subtypes of infertile groups, the deletions …