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Articles 99541 - 99570 of 2916981
Full-Text Articles in Entire DC Network
New Definitions Of Library Use: Experimentation, Discovery, And Creation (Edc) Within A Library, Holt Zaugg
New Definitions Of Library Use: Experimentation, Discovery, And Creation (Edc) Within A Library, Holt Zaugg
Faculty Publications
Why did you do this activity, project, or research?
Over the last decade, libraries have shifted from being primarily repositories for information and resources to active learning centers. Physical resources (e.g., books, journals, manuscripts) have moved to online access. Librarian roles have adjusted how they help patrons find and access resources in their local library and beyond, resulting in impactful input on research, learning, and scholarly endeavors. Additionally, due to a reduced need for storing materials, libraries have developed collaborative and innovative spaces to meet patrons’ needs. These spaces include group study rooms, experiential studios, makerspaces, green rooms, and podcast …
Mutant P53 Gain Of Function: Why Many See It, Why Some Do Not, Guillermina Lozano, Carol Prives, Kanaga Sabapathy
Mutant P53 Gain Of Function: Why Many See It, Why Some Do Not, Guillermina Lozano, Carol Prives, Kanaga Sabapathy
Faculty, Staff and Student Publications
Mutations in the TP53 tumor-suppressor gene in human cancer are unique in that 60% to 70% are of the missense variety, resulting in a full-length protein that is often highly expressed in patients' tumors. These missense mutant proteins often exhibit pro-oncogenic activities (referred to as gain of function) in mouse models and human cell lines and correlate with poor cancer prognosis in some cases.
Phage-Induced Protection Against Lethal Bacterial Reinfection, Yikun Xing, Haroldo J Hernandez Santos, Ling Qiu, Samantha R Ritter, Jacob J Zulk, Rachel Lahowetz, Kathryn A Patras, Austen L Terwilliger, Anthony W Maresso
Phage-Induced Protection Against Lethal Bacterial Reinfection, Yikun Xing, Haroldo J Hernandez Santos, Ling Qiu, Samantha R Ritter, Jacob J Zulk, Rachel Lahowetz, Kathryn A Patras, Austen L Terwilliger, Anthony W Maresso
Faculty, Staff and Students Publications
Bacteriophages, or phages, are viruses that target and infect bacteria. Due to a worldwide rise in antimicrobial resistance (AMR), phages have been proposed as a promising alternative to antibiotics for the treatment of resistant bacterial infections. Up to this point in history, phage use in preclinical animal studies, clinical trials, and emergency-use compassionate care cases has centered around the original observation from 1915 showing phage as lytic agent, and thus a treatment that kills bacteria. Here, we describe an activity associated with phage therapy that extends beyond lytic activity that results in long-term protection against reinfection. This activity is potent, …
Race, Reflection And Resistance: An Autoethnographic Journey In Social Studies Curriculum Development, Jesse Nicholas Hendryx-Dobson
Race, Reflection And Resistance: An Autoethnographic Journey In Social Studies Curriculum Development, Jesse Nicholas Hendryx-Dobson
Dissertations and Theses
The purpose of this qualitative, self- study, autoethnography is to explore my instructional practices, strategies and decision making as I navigate my attempts to build a more anti-racist, racial justice social studies curriculum in a predominantly white school environment. Critical Race Theory as well as racial literacy provided me with a conceptual framework, but also with the language I need to articulate the research problem and my findings. Three research questions guided how I collected and analyzed my data: 1) How do I plan social studies lessons that address the topic of race/racism? 2) How can I use social studies …
Unframing Spatial Presence And Resonating Aesthetic Presence : A “Continuous Interaction” Of Visitor Engagement With Chinese Art, Yi Zhu
Lingnan Theses (MPhil & PhD)
Digital technologies, as a prevalent method of display in museums, has been widely used in the presentation and creation of Chinese art, such as software, hardware, and interactive installations in exhibitions. According to Peng Feng (2022), digital technologies can effectively disseminate Chinese classical artworks while enriching visitors’ experience, enhancing their perceptions of aesthetic concepts and facilitating their understanding of the artworks. However, current studies are primarily focused on the social and cultural background information conveyed by the objects, rather than the visitor experiences in the process of interaction with the artworks. Digital technologies can engage visitors through active interaction with …
Public Health Simulation Infused Program (Pship) Toolkit, Desiree A. Díaz, Mindi Anderson, Francisco Guido-Sanz, Peggy Hill, Samantha Stephenson, Heather Peralta, Syretta Spears, Geraldine Luzincourt
Public Health Simulation Infused Program (Pship) Toolkit, Desiree A. Díaz, Mindi Anderson, Francisco Guido-Sanz, Peggy Hill, Samantha Stephenson, Heather Peralta, Syretta Spears, Geraldine Luzincourt
Faculty Scholarship and Creative Works
Project Narrative
PURPOSE AND NEED
Purpose: Priorities set forth by the Health Resources & Services Administration (HRSA) are addressed in the proposed simulation program in an effort to meet curricular needs and foster care to the medically underserved in Florida, further exposing students to public healthcare needs. Interprofessional (nursing and social work) and intraprofessional (undergraduate nurse and Nurse Practitioner [NP]) instruction is essential in the simulation-based education (SBE) program, promoting important content on identifying risk factors and health assessment of the medically underserved community (MUC) (Education Priority 2, §831). Coordination of medical care is a vicarious learning opportunity for all …
Creation Of An Open Access Textbook, Sue Ann Gardner
Creation Of An Open Access Textbook, Sue Ann Gardner
University of Nebraska-Lincoln Libraries: Presentations
Slide presented during the PRCA Research Celebration, June 3, 2025, in the University Libraries, University of Nebraska-Lincoln titled Creation of an Open Access Textbook, about the development and publication of Concepts in Animal Parasitology, co-edited by Scott L. Gardner and Sue Ann Gardner and published by Zea Books (Lincoln, Nebraska, USA) in 2024.
Comparison Between Pipeline Embolization Device (Ped) Versus Flow Redirection Endoluminal Device (Fred) For Intracranial Aneurysms: A Comprehensive Systematic Review And Meta-Analysis, Seyed Maroufi, Mohammad Fallahi, Muhammad Waqas, Othman Bin-Alamer, Manisha Koneru, Joanna Roy, Jane Khalife, Hamza Shaikh, Daniel Tonetti
Comparison Between Pipeline Embolization Device (Ped) Versus Flow Redirection Endoluminal Device (Fred) For Intracranial Aneurysms: A Comprehensive Systematic Review And Meta-Analysis, Seyed Maroufi, Mohammad Fallahi, Muhammad Waqas, Othman Bin-Alamer, Manisha Koneru, Joanna Roy, Jane Khalife, Hamza Shaikh, Daniel Tonetti
Department of Neurosurgery Faculty Papers
OBJECTIVES: The performance of the Pipeline Embolization Device (PED) and relatively newer double-layered Flow Re-Direction Endoluminal Device (FRED) have been studied for the treatment of intracranial aneurysms, but direct comparisons between PED and FRED are limited. The current systematic review aims at comparing the efficacy and safety of PED and FRED.
METHODS: A systematic review of the literature was conducted according to the PRISMA guideline. PubMed, Embase, Scopus, Web of Science, and Cochrane Library were searched, and related records were identified. A meta-analysis of double-arm studies comparing PED and FRED was conducted on angiographic and clinical outcomes, retreatment rates, and …
An Instrumental Case Study Of Low-Income, African-American Parents’ Perceptions And Experiences Of Parent-Teacher Relationships In Midwestern, Pk-8 U.S. Public Schools, Rochelle Rolle
Theses and Dissertations from DePaul University
Positive parent-teacher relationships are vital for student success in pre-kindergarten through eighth grade, particularly among low-income, African-American parents and guardians. Research suggests respect, trust, and open communication as key factors for cultivating positive parent-relationships; however, race and social class have influenced the development of African-American parents and guardians’ relationships with their children’s teachers. This instrumental case study investigated how six low- income, African-American parents and guardians in Midwestern PK-8 public schools perceive their relationships with their children’s teachers. Using a qualitative method approach, the study was guided by the Hoover-Dempsey and Sandler Model of the Parental Involvement Process and Critical …
Co-Designing A Digital Nutrition Intervention For Individuals With Severe Mental Illness Using The Behaviour Change Wheel, Ciara O'Sullivan, Tara Coppinger, Indika Dhanapala, Alison Merrotsy
Co-Designing A Digital Nutrition Intervention For Individuals With Severe Mental Illness Using The Behaviour Change Wheel, Ciara O'Sullivan, Tara Coppinger, Indika Dhanapala, Alison Merrotsy
Publications
Title: Co-Designing a Digital Nutrition Intervention for Individuals with Severe Mental Illness Using the Behaviour Change Wheel
Purpose: This study aims to develop a digital nutrition intervention for individuals with severe mental illness (SMI) residing in high-support mental health hostels, using a theoretically informed co-design approach.
Design/methodology/approach: This study will employ a participatory, mixed-methods approach, incorporating Public and Patient Involvement (PPI) to ensure user-centred intervention design. The Behaviour Change Wheel (BCW) guides the selection of intervention functions, Behaviour Change Techniques (BCTs) and delivery methods. The study will consist of three phases: (1) Preparation, (2) Co-Design, and (3) Finalisation.
Findings: Data …
Nazor V. Sydney Sol Group, Ltd.
Nazor V. Sydney Sol Group, Ltd.
All Decisions
In this loft tenant action, the court modified the lower court's order, reinstating claims for rent overcharge, unjust enrichment, and breach of warranty of habitability. The court held that court-ordered use and occupancy payments are not "voluntarily paid" rent under MDL § 302(b), allowing these claims to proceed in a related action. The court also reinstated a claim for accounting of the security deposit and attorneys' fees, finding the landlord failed to prove non-commingling. However, claims for harassment, retaliatory eviction, and constructive eviction were dismissed.
Rooted In Research, Jeremy Gasowski
Modeling The Mark 26 Guided Missile Launching System: Exploring Its Role In U.S. Naval Doctrine In The Late Cold War, Ryan Matthew Cabico
Modeling The Mark 26 Guided Missile Launching System: Exploring Its Role In U.S. Naval Doctrine In The Late Cold War, Ryan Matthew Cabico
Theses and Dissertations
The Mark 26 Guided Missile Launch System was an innovative and modular upgrade from previous systems for the United States Navy at a critical development point during the Cold War. Its incorporation into the Virginia-Class, especially the USS Arkansas, exemplified the rapidly evolving scope and demands of naval warfare in the modern era, and the requirements of individual vessels and component parts of the Navy to fulfill U.S. naval doctrine in this era. This same rapid evolution in technology and the global political landscape would ultimately seal the fate of the Mark 26 and USS Arkansas, with their designed innovations …
A Review Of The Persistent Burden Of Post-Covid Headaches In Children, Hajir Karim Abdul-Husseein
A Review Of The Persistent Burden Of Post-Covid Headaches In Children, Hajir Karim Abdul-Husseein
Hilla University College Journal For Medical Science
This review focuses on the problem of the headache occurrence in children after COVID. Studies indicated that headaches and fatigue are common long-term symptoms in school-age children following COVID-19 infection. The prevalence of persistent post-COVID headaches in children varies between 5% and 25.4%, often lasting for at least 3 months. Exploration of potential pathophysiological mechanisms of post-COVID headaches in children includes the trigemino-vascular system, viral-induced inflammation, immune system dysregulation, and compromised cerebral blood flow. Age-related immune responses and the expression of receptors like ACE2 may also play a role in pediatric headache development. The features of post-COVID headaches in children …
Exploring Educator Psychological Capital Through Participation In A Coordinated School Violence Prevention Approach, Stephanie Lorraine Neff
Exploring Educator Psychological Capital Through Participation In A Coordinated School Violence Prevention Approach, Stephanie Lorraine Neff
Walden Dissertations and Doctoral Studies
This study is a description of how educators’ participation in a coordinated approach to violence prevention contributed to employee wellness and school climate. Using principles of psychological capital (PsyCap) theory, archival focus group and interview data were used to describe educator experiences during implementation of a 3-year coordinated approach to school violence in a mid-sized public school district. Findings of the analysis revealed consistent references to feelings of hope, efficacy, resilience, and optimism throughout the study, but with slight shifts in frequency each year based on both internal (i.e. skill development, relationship-building), and external (i.e. administrative support, policy directives, broader …
Experiences Of Discrimination And Neighborhood Cohesion In Risk Of Poor Mental Health Outcomes Among Older, Community-Dwelling Participants In The Regards Study, Marquita S. Brooks
Experiences Of Discrimination And Neighborhood Cohesion In Risk Of Poor Mental Health Outcomes Among Older, Community-Dwelling Participants In The Regards Study, Marquita S. Brooks
All ETDs from UAB
Mental health disorders impact approximately 14% of persons aged 65 and older and often are undertreated or underrecognized. Assessment of factors that link environmental, sociocultural, behavioral, and biological factors to overall health and disease is integral to guiding research on health disparities in older populations. Although research suggests associations between environmental factors (i.e., discrimination and neighborhood cohesion) and mental health outcomes, there is limited research on these factors within the U.S. Therefore, our study assessed the relationship between discrimination, neighborhood cohesion, and mental health outcomes in the REasons for Geographic and Racial Differences in Stroke (REGARDS) study, a national, prospective …
Buklad Asin Baláog: Pagrigmat Sa Obra-Publiko Ni Raul Alcomendas, Dennis Gonzaga
Buklad Asin Baláog: Pagrigmat Sa Obra-Publiko Ni Raul Alcomendas, Dennis Gonzaga
Katipunan
Inihahayag ni Gonzaga kung paanong isang biswal na pagninilay ang walang pamagat na pinta ni Raul Alcomendas na nakasabit sa loob ng Metropolitan Cathedral ng Lungsod Naga. Isa itong mapagmuning pagtatagpi-tagpi ng kasaysayan ng Naga mula sa mga sinaunang pamayanan bago dumating ang mga Español, patungo sa panahong kolonyal, at hanggang sa kontemporanyong yugto ng politikal at kultural na kamalayan ng mga Bikolano. Pinag-aaralan dito ni Gonzaga kung paano nakukuhang pagkasunduin ni Alcomendas sa kaniyang sining ang madalas magkakatunggaling puwersa ng sekular at relihiyoso, tradisyonal at moderno, industriyal at agrikultural sa pamamagitan ng bihasang pagkontrol sa tonalidad at armonya ng …
Benefits And Challenges Of Collaborative Networks Addressing Food System Disruptions During The Covid-19 Pandemic, Dikshya Dahal, Tania Schusler
Benefits And Challenges Of Collaborative Networks Addressing Food System Disruptions During The Covid-19 Pandemic, Dikshya Dahal, Tania Schusler
School of Environmental Sustainability: Faculty Publications and Other Works
The COVID-19 pandemic disrupted food systems with disproportionate impacts on marginalized social groups, which in the USA included racial and ethnic minorities, working class families, immigrants, seniors, and people with disabilities, among others. The pandemic also greatly affected the operations of nonprofit organizations, which play important roles in disaster response. We explored how social networks supported non-profit organizations’ efforts to address increased food insecurity and food-related business disruptions during the pandemic in the Chicago region, IL, USA. We used mixed methods including a Social Network Analysis (SNA) of 48 organizations and their reported partners plus focus group discussions with representatives …
Comparing Emotional Facial Expressions Produced During Personal Narrative Discourse By People With And Without Aphasia, Chloe K. Houghton
Comparing Emotional Facial Expressions Produced During Personal Narrative Discourse By People With And Without Aphasia, Chloe K. Houghton
Theses and Dissertations
This study investigated the differences in emotional facial expressivity between people with aphasia (PWA) and control participants during emotional discourse tasks. Participants consisted of 26 PWA and 26 control participants from Aphasia Talk Bank who retold a stroke or illness story and an important life event story, totaling 104 video files. Undergraduate research assistants were trained to code emotional facial expressions according to valence, intensity, and duration utilizing a modified Facial Expression Coding System (FACES; Kring & Sloan, 1991). Dependent variables included positive frequency, negative frequency, positive intensity, and negative intensity. Results from this study demonstrate that female participants used …
Audiological Characteristics And Associations With Psychological Inflexibility, Karen Muñoz, Bailey Sorensen, Aryn Kamerer, Michael P. Twohig
Audiological Characteristics And Associations With Psychological Inflexibility, Karen Muñoz, Bailey Sorensen, Aryn Kamerer, Michael P. Twohig
Psychology Faculty Publications
Purpose:
The aim of this study was to describe psychological inflexibility for hearing difficulty for a sample of adults seeking hearing help and explore associations with demographic and audiological characteristics.Method:
Archival data from 226 clinical electronic medical records at one university clinic were analyzed for this retrospective exploratory study. Audiometric test findings and results from the Acceptance and Action Questionnaire–Adult Hearing Loss (AAQ-AHL) were extracted for adult patients seen between June 1, 2022, and February 29, 2024.Results:
The majority had a bilateral hearing loss (64%), 10% had a unilateral hearing loss, and 26% had bilateral pure-tone averages better …Posterior Predictive Design For Phase I Clinical Trials, Chenqi Fu, Shouhao Zhou, J Jack Lee
Posterior Predictive Design For Phase I Clinical Trials, Chenqi Fu, Shouhao Zhou, J Jack Lee
Faculty, Staff and Student Publications
Interval-based designs represent cutting-edge adaptive methodologies for phase I clinical trials to identify the maximum tolerated dose (MTD). These designs exhibit robust performance comparable to more intricate, model-based designs, and their pretabulated decision rule enables them to be implemented as simply as the conventional algorithm-based designs. In this paper, we introduce the posterior predictive (PoP) design, a novel interval-based design that leverages advanced Bayesian predictive hypothesis testing techniques for dose escalation and de-escalation. Our work moves beyond the existing model-assisted interval-based designs by achieving global optimality in dose transition. Theoretically, the global optimality ensures that the proposed design can consistently …
Reading For Pleasure, Writing For Impact: A Reflection On How An Assessment Task Fosters Advocacy In An Undergraduate English Service-Learning Module, Dermot Burns
Irish Journal of Academic Practice
Service-learning is a valuable pedagogy through which to facilitate and nurture the skills and knowledge pertaining to advocacy. A unique approach to foster this learning is being practised in the Discipline of English at University of Galway through its assessment design for an undergraduate module entitled ‘Service-learning: reading and writing with primary school children’. This paper establishes the significance of advocacy in service-learning and argues for the relevance of advocating for Reading for Pleasure with children. It describes how a mid-term assignment encourages students to share both their practical experiences in a local primary school and their emergent expertise, gained …
An Isometry Theorem For Persistent Homology Of Circle-Valued Functions, Nathan Broomhead, Mariam Pirashvili
An Isometry Theorem For Persistent Homology Of Circle-Valued Functions, Nathan Broomhead, Mariam Pirashvili
School of Engineering, Computing and Mathematics
This paper explores persistence modules for circle-valued functions, presenting a new extension of the interleaving and bottleneck distances in this setting. We propose a natural generalisation of barcodes in terms of arcs on a geometric model associated to the derived category of quiver representations. The main result is an isometry theorem that establishes an equivalence between the interleaving distance and the bottleneck distance for circle-valued persistence modules.
Marking Tidetime: Mudlarking As Intertidal Performance, Sarah Blissett
Marking Tidetime: Mudlarking As Intertidal Performance, Sarah Blissett
School of Art, Design and Architecture
No abstract provided.
Cmsi Translations #19: Lessons And Thoughts From The Struggle For Command Of The Sea In The Red Sea, Zhao Jiaxu, Huang Chunyu
Cmsi Translations #19: Lessons And Thoughts From The Struggle For Command Of The Sea In The Red Sea, Zhao Jiaxu, Huang Chunyu
CMSI Translations
Since mid-November 2023 to the present Houthi armed forces in Yemen have continued to hijack and attack vessels in the Red Sea that "use Israeli ports" or "engage in trade with Israel" to oppose Israel's military operations in Gaza and disrupt military assistance to Israel from the United States, the United Kingdom, and other countries. As of April 1, 2024, over 86 vessels related to the United States, the United Kingdom, Israel, and other countries have been attacked. The Houthis continue to maintain control over the Red Sea, forcing vessels from these countries to risk damage and loss of life …
Lipoprotein(A) And Heart Failure Among Black And White Participants In Atherosclerosis Risk In Communities Study, Framingham Offspring Study, And Multi-Ethnic Study Of Atherosclerosis: The Pooling Project, Sarah Nomura, Weihua Guan, Yixin Zhang, Geoffrey H Tison, Hiroaki Ikezaki, Margaret R Diffenderfer, Ching-Ti Liu, Ron C Hoogeveen, Christie M Ballantyne, Ernst J Schaefer, Michael Y Tsai
Lipoprotein(A) And Heart Failure Among Black And White Participants In Atherosclerosis Risk In Communities Study, Framingham Offspring Study, And Multi-Ethnic Study Of Atherosclerosis: The Pooling Project, Sarah Nomura, Weihua Guan, Yixin Zhang, Geoffrey H Tison, Hiroaki Ikezaki, Margaret R Diffenderfer, Ching-Ti Liu, Ron C Hoogeveen, Christie M Ballantyne, Ernst J Schaefer, Michael Y Tsai
Faculty, Staff and Students Publications
Background: This study investigated Lp(a) (lipoprotein(a)) levels with heart failure (HF) incidence overall and ejection fraction (EF) subtypes among Black and White participants in a pooled analysis of MESA (Multi-Ethnic Study of Atherosclerosis), FOS (Framingham Offspring Study), and ARIC (Atherosclerosis Risk in Communities Study).
Methods: This study was conducted among 16 771 White and Black participants in ARIC (N=10 347), MESA (N=4150), and FOS (N=2274). Baseline was time of Lp(a) measurement (ARIC Visit 4: 1996-1998; MESA Visit 1: 2000-2002; FOS Cycle 6: 1995-1998). HF with reduced EF (HFrEF) was defined as EF < 50% and ≥50% as HF with preserved EF (HFpEF). Cox proportional hazards regression was used to evaluate associations between Lp(a) (log-transformed continuous, dichotomized at ≥30 mg/dL and ≥50 mg/dL, and quartiles) and HF (overall, HFpEF, HFrEF) in the overall population and stratified by race. Analyses were replicated excluding prior history of myocardial infarction.
Results: There were 2759 HF cases (HFpEF N=859; …
Convergence Research For Microplastic Pollution At The Watershed Scale, Heejun Chang, Elise F. Granek, Amanda Gannon, Jordyn M. Wolfand, Janice Brahney
Convergence Research For Microplastic Pollution At The Watershed Scale, Heejun Chang, Elise F. Granek, Amanda Gannon, Jordyn M. Wolfand, Janice Brahney
Geography Faculty Publications and Presentations
Microplastics are found in Earth’s atmosphere, lithosphere, hydrosphere, pedosphere, and ecosphere. While there is a growing interest and need to solve this grand challenge in both the academic and policy realms, few have engaged with academics, policymakers, and community partners to co-identify the problem, co-design research, and co-produce knowledge in tackling this issue. Using a convergence research framework, we investigated the perception of microplastic pollution among different end users, delivered educational materials to K-12 teachers and practitioners, and identified key sampling points for assessing environmental microplastic concentrations in the Columbia River Basin, United States. Three community partner workshops identified regional …
The Acute Impact Of Game-Based Physical Education On The Mood States Of Middle School Students, John Nemeth
The Acute Impact Of Game-Based Physical Education On The Mood States Of Middle School Students, John Nemeth
Doctorate in Kinesiology
Mental health disorders represent a massive global health burden, with close to one billion people currently affected. Access to treatment and medical care remains low, especially among children. Increased physical activity (PA) is a widely recognized and accessible method for improving mental health, with substantial evidence supporting its benefits. Physical education (PE) is a structured, school-based environment that promotes PA and increased movement, but research examining its impact on mood is limited. This study examined mood changes in middle school students following PE participation in two game-based activities: handball (team sports) and badminton (partner games). A quasi-experimental design was used …
Economic And Environmental Impact Of Recovering And Upgrading Lignin Via The Alpha Process On An Ethanol Biorefinery, Daniel G. Kulas, Robert Handler, Graham Tindall, Bronson Lynn, Mark Thies, David Shonnard
Economic And Environmental Impact Of Recovering And Upgrading Lignin Via The Alpha Process On An Ethanol Biorefinery, Daniel G. Kulas, Robert Handler, Graham Tindall, Bronson Lynn, Mark Thies, David Shonnard
Michigan Tech Publications
Lignin valorization is limited by both impurities and broad molecular weight (MW) distributions. The Aqueous Lignin Purification using Hot Agents (ALPHA) process exploits the novel liquid–liquid equilibrium that exists between lignin and hot, one-phase solutions of aqueous renewable solvents to simultaneously purify and fractionate raw bulk lignins. Our analysis considered the valorization of lignin recovered from two ethanol biorefinery waste streams, black liquor and lignin cake. By applying sequential ALPHA stages, distinct lignin fractions of controlled MW and purity were isolated suitable for producing carbon fibers, polyurethane foams (PUF), and activated carbons (ACs). Surprisingly, only a single extraction stage was …
Xbp1s-Edem2 Prevents The Onset And Development Of Hfpef By Ameliorating Cardiac Lipotoxicity, Oveena Fonseka, Rida Raja, Claire Ross, Sanskruti R Gare, Jiayan Zhang, Susanne S Hille, Katharine King, Andrea Ruiz-Velasco, Namrita Kaur, Xinyi Chen, Jessica M Miller, Riham R E Abouleisa, Qinghui Ou, Zhiyong Zou, Xiangjun Zhao, Cristian Sotomayor-Flores, Derk Frank, Eileithyia Swanton, Martin R Pool, Sara Missaglia, Daniela Tavian, Gabriele G Schiattarella, Tao Wang, Luigi Venetucci, Christian Pinali, Martin K Rutter, Bernard D Keavney, Elizabeth J Cartwright, Tamer M A Mohamed, Oliver J Müller, Wei Liu
Xbp1s-Edem2 Prevents The Onset And Development Of Hfpef By Ameliorating Cardiac Lipotoxicity, Oveena Fonseka, Rida Raja, Claire Ross, Sanskruti R Gare, Jiayan Zhang, Susanne S Hille, Katharine King, Andrea Ruiz-Velasco, Namrita Kaur, Xinyi Chen, Jessica M Miller, Riham R E Abouleisa, Qinghui Ou, Zhiyong Zou, Xiangjun Zhao, Cristian Sotomayor-Flores, Derk Frank, Eileithyia Swanton, Martin R Pool, Sara Missaglia, Daniela Tavian, Gabriele G Schiattarella, Tao Wang, Luigi Venetucci, Christian Pinali, Martin K Rutter, Bernard D Keavney, Elizabeth J Cartwright, Tamer M A Mohamed, Oliver J Müller, Wei Liu
Center for Medical Ethics and Health Policy Staff Publications
Background: Morbidity and mortality of heart failure with preserved ejection fraction (HFpEF) is increased in metabolic disorders. However, options for preventing and treating these prevalent outcomes are limited. Intramyocardial lipotoxicity contributes to cardiac dysfunction. Here, we investigate the mechanisms underlying EDEM2 (endoplasmic reticulum degradation-enhancing alpha-mannosidase-like protein 2) regulation of cardiac lipid homeostasis and assess strategies that inhibit the incidence and progression of HFpEF.
Methods: Metabolic stress was induced in C57BL/6 male mice using a high-fat diet and Nω-nitro-L-arginine methyl ester. The recombinant adeno-associated virus 9 delivery system was used for loss- and gain-of-function studies. Palmitic acid and oleic acid …