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A Mixed Methods Survey To Highlight Retrospective Drug Spending, Dillon Peter Thorpe Jun 2025

A Mixed Methods Survey To Highlight Retrospective Drug Spending, Dillon Peter Thorpe

College of Science and Health Theses and Dissertations

The financial impact of substance use is poorly understood. What research has been conducted has focused on societal and medical costs, rarely on the personal finances of substance users. Less research has been conducted on the finances of people currently in recovery and abstinence. To fill in this gap, 284 current Oxford House residents completed a survey that inquired about demographics, spending habits, and reasons for staying in Oxford House. Following analysis, it was found that previous drug/alcohol spending is a highly variable metric, with a range of $0-$30,000 per month. In addition, the sample was homogenous in terms of …


The Effect Of Reading Goals On Conspiracy Believability And Memorability, Leah Patricia O'Neill Jun 2025

The Effect Of Reading Goals On Conspiracy Believability And Memorability, Leah Patricia O'Neill

College of Science and Health Theses and Dissertations

Previous research shows that individuals who are assigned different goals for reading remember and comprehend text differently, which might also influence how individuals read texts that contain conspiracy theories. This research has revealed a connection between scores on the Schizotypal Personality Questionnaire-Brief (SPQ-B) and conspiracy theory belief, such that those who score higher are more likely to believe in conspiracy theories. Therefore, this study investigated the influence of reading goals (i.e., study vs entertainment) and different types of conspiracy theories (i.e., familiar and less familiar) on participant’s believability ratings for conspiracy texts. Participants were assigned a reading goal prior to …


The Role Of Imagination In Archaeology: Linking Contemplation And Method At The Amache National Historic Site, Sami Zepponi Jun 2025

The Role Of Imagination In Archaeology: Linking Contemplation And Method At The Amache National Historic Site, Sami Zepponi

Electronic Theses and Dissertations

Archaeology is both a science and an interpretative process, blending material discovery with imagination to reconstruct past experiences. This research, conducted through the 2024 University of Denver Amache Field School, explores the archaeological imagination and the creative and cognitive engagement that shapes historical interpretation. Using Amache, a WWII Japanese American incarceration site, as a case study, this thesis examines how material culture, landscape modifications, and reflection inform archaeological understanding. This study explores how imagination connects tangible findings to cultural narratives by integrating community-based archaeology, place and landscape theory, and contemplative inquiry. Findings highlight imagination as essential to archaeology, enabling deeper …


Peering Into The Past And Future: Connection, Challenge, Growth, And Rural Peer Mentors, Tinker Elizabeth Jacobs Duclo Jun 2025

Peering Into The Past And Future: Connection, Challenge, Growth, And Rural Peer Mentors, Tinker Elizabeth Jacobs Duclo

Electronic Theses and Dissertations

Peer mentoring is a recognized strategy for supporting student success, academic persistence, and belonging in higher education. However, while mentee benefits are well-documented, the long-term effects on peer mentors (PMs) remain underexplored, particularly at Rural-Serving Institutions (RSIs). My evaluation bridges that gap by examining the lasting impact of PM service through a qualitative evaluation of the Rifle Colorado Mountain College (CMC) Peer Mentor Program. Guided by Rural Cultural Wealth (RCW) theory and using the Most Significant Change (MSC) model within a constructivist framework, my evaluation centers alumni PM voices, gathering their reflections on the significant changes and impacts of their …


Home Bound: Explaining The Neoliberalization Of Regional Public University Districts Through An Explanatory Sequential Mixed Methods Design, Becket C. Duncan Jun 2025

Home Bound: Explaining The Neoliberalization Of Regional Public University Districts Through An Explanatory Sequential Mixed Methods Design, Becket C. Duncan

Electronic Theses and Dissertations

I examined housing costs in neoliberalized consumer spaces (Cunningham, 2016; Saunders & Ramírez, 2017) in regional public university (Orphan, et al., 2022) districts. I use geographic methods (Jonas, et al., 2015; Daché-Gerbino, 2018) with an explanatory sequential mixed methods design and a complex case study approach (Creswell & Plano Clark, 2018). Results from my spatial analyses showed that residents who live within one-half mile of universities spend more on monthly housing costs ($1,331) than those who do not ($1,227) except in the case of regional public universities ($1,184). Results from a regression analysis demonstrated that eight institutional variables predicted 33.2% …


Survival Guide For Queer Families In Heteronormative Healthcare: Liberatory Consciousness And The Paradox Of Dependent Healthcare, A Critical Policy Discourse Analysis, Dwenna A. Holden Jun 2025

Survival Guide For Queer Families In Heteronormative Healthcare: Liberatory Consciousness And The Paradox Of Dependent Healthcare, A Critical Policy Discourse Analysis, Dwenna A. Holden

Electronic Theses and Dissertations

In this study I explored and analyzed how the queer experiences of an anonymous higher education institution in the western United States’ self-identified queer faculty and staff intersected with the discursive framing of the college’s dependent healthcare structure and documents. Within a critical paradigm I designed research around a high-density theoretical approach to weaving various branches of queer theory together with critical theory around policy and law in relation to queer bodies and hostile heteronormative policy environments. I arrived at solutions based in complaint, survival, and transformation. I used critical policy discourse analyses to interrogate the college’s dependent healthcare documents …


Stewards Of Place, Stewards Of Democracy: The Role Of Regional Public Universities In Rural Political Well-Being, Katie Kleinhesselink Jun 2025

Stewards Of Place, Stewards Of Democracy: The Role Of Regional Public Universities In Rural Political Well-Being, Katie Kleinhesselink

Electronic Theses and Dissertations

This qualitative embedded single-case study explored how a rural-serving regional public university (RPU) contributed to the political well-being of its politically polarized service region ahead of the 2024 presidential election. Guided by the stewardship of political place theoretical framework, which integrates rural consciousness, the Community Capitals Framework, and the stewardship of place framework for RPUs’ public engagement, the study utilized policy discourse analysis to examine regional residents' and internal constituents' perceptions regarding WPU’s role in promoting regional political well-being. Data collection included semi-structured interviews, direct observations of campus civic engagement events, and institutional document reviews.

The study demonstrates that regional …


Chingonas In Charge: A Phenomenological Study Of Latina Educational Leaders In Colorado, Paulina Yvette Lerma-Banuelos Jun 2025

Chingonas In Charge: A Phenomenological Study Of Latina Educational Leaders In Colorado, Paulina Yvette Lerma-Banuelos

Electronic Theses and Dissertations

Despite comprising 76% of the U.S. teaching workforce (2017−2018), Latina women held only 8.5% of principal roles and 2.7% of superintendent positions. In places such as Colorado, where Latinos make up 15.1% of the population, this inequity highlights the pressing necessity for better representation. The present study used a qualitative phenomenological approach to explore the fundamental essence and attributes of leadership among Latina K−12 administrators in Colorado, with a focus on the concept of “chingona” and its transformative significance in their professional journeys. The name “chingona” was historically rejected by young Latina women because of connotations to being aggressive or …


From Deficit To Asset: Developing An Equitable Early Warning System For Ninth Grade Success, Stephanie Mann Jun 2025

From Deficit To Asset: Developing An Equitable Early Warning System For Ninth Grade Success, Stephanie Mann

Electronic Theses and Dissertations

I explored the design and implementation of an asset-based Early Warning System (EWS) to support ninth-grade students at The Academy, a PK-12 charter school, during their critical high school transition. Using Practical Action Research, I addressed the question: How might a comprehensive EWS leverage student assets and systemic support to ensure success? Over one academic year, the study unfolded in two phases: Phase I employed qualitative methods—interviews, focus groups, and data reviews—to identify gaps, while Phase II developed an enhanced EWS, integrating map and street data for richer student profiles and staff collaboration. Findings underscore a human-powered EWS rooted in …


A Clinical Practice Guideline For Enhanced Rehabilitation Assessment In Poststroke Patients, Chanda Honeywood Jun 2025

A Clinical Practice Guideline For Enhanced Rehabilitation Assessment In Poststroke Patients, Chanda Honeywood

Walden Dissertations and Doctoral Studies

This doctoral project aimed to develop clinical practice guidelines (CPG) to strengthen the assessment of poststroke patients for rehabilitation. The project sought to adopt an evidence-based approach to develop standardized recommendations that can help in the timely and appropriate rehabilitation of stroke survivors, thereby reducing the risk of long-term disability and readmissions. Stroke is a significant cause of disability and poor functional recovery, increased healthcare costs, and lower quality of life for patients occur because of poor rehabilitation assessment. While rehabilitation protocols already exist, discrepancies in patient evaluations result in intervention delays and ineffective uptake of rehabilitation programs, limiting the …


The Motivating Factors Of A Multigenerational Workplace Based On Work Values And Reinforcements, Alaina Lister Jun 2025

The Motivating Factors Of A Multigenerational Workplace Based On Work Values And Reinforcements, Alaina Lister

Walden Dissertations and Doctoral Studies

There are currently four generations in the workplace—Generation Z, millennials, Generation X, and baby boomers—each having its own values and motivations due to different life experiences. Leaders are facing new challenges regarding how to motivate each generation in relation to rewards, recognition, and work values. It was unknown whether there are empirical differences in motivation and leadership preferences based on generational cohort. The purpose of this study was to examine how the members of four different generations are motivated based on their preferred rewards and recognition, and the work values they hold. The targeted population were members of Generation Z, …


Employee Engagement And Productivity Among Remote Workers In The Finance Industry, Mauriom Ndikeh Jun 2025

Employee Engagement And Productivity Among Remote Workers In The Finance Industry, Mauriom Ndikeh

Walden Dissertations and Doctoral Studies

The COVID-19 pandemic and its related restrictions made remote work a defining feature of the modern workforce. Some finance industry leaders lack effective employee engagement strategies to increase productivity in remote work environments. The purpose of this qualitative pragmatic inquiry project was to identify and explore successful employee engagement strategies some finance industry leaders used to increase productivity in remote work environments. This project was grounded in Kahn’s employee engagement theory. The participants were six finance industry leaders from financial organizations in the Northeast and Mid-Atlantic regions of the United States. Data were collected using semistructured Zoom interviews, field notes, …


To Study The Correlation Between Project Management Methodologies, Leadership Styles, And Team Engagement., Mouna Ittira Subbaiah Jun 2025

To Study The Correlation Between Project Management Methodologies, Leadership Styles, And Team Engagement., Mouna Ittira Subbaiah

Harrisburg University Dissertations and Theses

The software industry is expanding rapidly due to emerging technologies, innovative business strategies, and evolving customer demands. Software projects vary in complexity, requiring diverse approaches to ensure successful development from initiation to completion. This complexity has driven the adoption of continuous learning, lean principles, and agile methodologies. Modern methodologies prioritize flexibility, adaptability, productivity, inclusivity, and knowledge sharing. The choice of a particular method depends on organizational culture and project characteristics. The characteristics of the methodology will directly and indirectly influence team engagement. However, transitioning between methods can be challenging, involving significant costs and time investments. Recently, many organizations have shifted …


Roles Of Organic Agriculture For Water Optimization In Arid And Semi-Arid Regions, Shikha Sharma, Matt A. Yost, Jennifer R. Reeve Jun 2025

Roles Of Organic Agriculture For Water Optimization In Arid And Semi-Arid Regions, Shikha Sharma, Matt A. Yost, Jennifer R. Reeve

Plants, Soils and Climate Student Research

Water scarcity is a critical challenge in arid and semi-arid regions, where agricultural water consumption accounts for a significant portion of freshwater use. Conventional agriculture (CA) methods with high reliance on chemical and mechanical inputs often exacerbate this issue through soil degradation and water loss. This review aims to examine how different organic practices, such as mulching, cover cropping, composting, crop rotation, and no-till (NT) in combination with precision technologies, can contribute to water optimization, and it discusses the opportunities and challenges for the adoption and implementation of those practices. Previous findings show that organic agriculture (OA) may outperform CA …


In Living Memory: Curatorial Perspectives Of Jewish Heritage In Holocaust Public Histories, Hannah M. Lahti Jun 2025

In Living Memory: Curatorial Perspectives Of Jewish Heritage In Holocaust Public Histories, Hannah M. Lahti

Dissertations

Holocaust Museums present a history of the genocide of European Jews, while Jewish Museums represent the long history and diverse cultures of Jewish life. By examining Holocaust public histories in Poland and the United States, this dissertation outlines the historical and memorial conditions that inform museum exhibits, as well as the curatorial approaches that synthesize historical information, spatial contexts, and material culture into exhibition narratives and historical representation. This dissertation employs exhibition analysis to explain existing curatorial approaches in Holocaust public histories and identifies curatorial principles and methods of display that might translate to new exhibits. Informed by the models …


Regulation Of Spermatogenesis By The Notch Signaling Pathway, Emma O'Flaherty Jun 2025

Regulation Of Spermatogenesis By The Notch Signaling Pathway, Emma O'Flaherty

Master's Theses

The Notch signaling pathway plays a significant role in gonad development and spermatogenesis, but little is known about its specific targets in the testis. The Drosophila testis contains two populations of stem cells: germline stem cells and cyst stem cells, which give rise to differentiating germline and somatic cyst cells, respectively. Notch signaling is activated in the somatic cyst cells by the Delta ligand from the germline in a region of the testes coined the “transition zone”, where somatic cyst cells progress from early cyst cells surrounding gonialblasts and 2-cell germline cysts to late cyst cells surrounding 16-cell spermatocyte cysts. …


Language Style Evaluation Validation For Implementation On Artificial Intelligence-Enhanced Augmentative And Alternative Communication Devices, Meghan A. Hunter Jun 2025

Language Style Evaluation Validation For Implementation On Artificial Intelligence-Enhanced Augmentative And Alternative Communication Devices, Meghan A. Hunter

Theses and Dissertations

This study explored various methods of evaluating language style for integration into prompts designed for a sophisticated augmentative and alternative communication (AAC) device. A total of 395 individuals without a language disorder were recruited via a crowdsourcing platform to complete five surveys. The initial four surveys were designed to assess individuals' language style using different approaches (questionnaire developed with ChatGPT, self-written, questionnaire developed by Hartman and McCambridge, and choosing tags). Following the completion of these four surveys, a fifth survey was dynamically created based on the responses in the previous four surveys. Each possible response in the fifth survey was …


Between Breaths: Healing And Being, Corina Yu Zhao Jun 2025

Between Breaths: Healing And Being, Corina Yu Zhao

Journal of Wellness

Burnout among healthcare professionals is an increasingly recognized crisis, yet pathways to resilience remain underexplored. This narrative chronicles the author’s personal journey from profound exhaustion to self-discovery and renewal. Through the integration of contemplative practices, nature exposure, and mindful nourishment, the author navigated the challenges of residency and emerged with a deeper understanding of well-being. By incorporating Isha Kriya meditation, Surya Kriya yoga, and self-inquiry practices rooted in Advaita Vedanta, the experience evolved into a transformative path of inner resilience. This report highlights the necessity of prioritizing self-care within the medical profession and offers evidence-backed insights into holistic wellness practices, …


A Toolkit For Improving School Climate: Lessons Learned From Action Research In A Network Of 16 Charter Schools, Grant E. Erwin Jun 2025

A Toolkit For Improving School Climate: Lessons Learned From Action Research In A Network Of 16 Charter Schools, Grant E. Erwin

Electronic Theses and Dissertations

Educators today face daunting challenges, especially in addressing persistent gaps in outcomes for historically underserved students from low-income and minority backgrounds. Practitioners often cite school climate as a key barrier to student success—an assertion supported by research linking school climate to students’ academic and personal outcomes. This study sought to improve school climate across 16 urban middle and high schools within one charter network. Using a mixed methods Collaborative Action Research (CAR) design over multiple years, the study triangulated academic research, external resources, and on-the-ground lessons to provide practical guidance for other educators. Data were collected from multiple stakeholders and …


Shrinkage Study In Photopolymerisable Hybrid Sol-Gel Through Holographic Patterning, Jamshed Aftab, Izabela Naydenova, Tatsiana Mikulchyk Jun 2025

Shrinkage Study In Photopolymerisable Hybrid Sol-Gel Through Holographic Patterning, Jamshed Aftab, Izabela Naydenova, Tatsiana Mikulchyk

Articles

Photopolymerisation induced shrinkage of holographic materials is one of the main factors which needs to be considered for designing holographic optical elements (HOEs) with high accuracy in light redirection with maximum efficiency. This work studies the shrinkage in photopolymerisable hybrid sol-gel (PHSG) by examining the properties of volume transmission gratings recorded in PHSG layers. It explores both the dependence of shrinkage on the holographic grating parameters (thickness, spatial frequency, slant angle) and the effect of material aging. By using the fringe-plane rotation model, shrinkage is found to have the maximum value of 1.37 % at 765 lines/mm (19.36° slant angle) …


The Modern Pilgrimage Of Umrah: The Convergence Of Spiritual Devotion And Pop-Consumer Culture In Indonesia, Syamsu Madyan, Habil Abyad, Imam Wahyudi Karimullah Jun 2025

The Modern Pilgrimage Of Umrah: The Convergence Of Spiritual Devotion And Pop-Consumer Culture In Indonesia, Syamsu Madyan, Habil Abyad, Imam Wahyudi Karimullah

International Journal of Religious Tourism and Pilgrimage

This study explores Umrah’s significant growth as a religious tourism model in Indonesian Muslim society. The discussion examines factors that influence that growth, from the increased income levels of Indonesian middle-class Muslims to the Umrah propaganda generated by the wave of social media. This study will also capture Umrah as a solution for Indonesian Muslims to the long waiting queue for Hajj quota in Indonesia, as it is seen as a good opportunity for religious commodification through the touristic market being exercised by stakeholders such as policymakers and travel agencies. As the Umrah tourist market will be analysed in this …


Marketing Management Of Cemetery-Based Religious Sites To Improve The Economic Level Of Society, Dian Mohammad Hakim, Imam Wahyudi Karimullah, Winarto Winarto, Maskuri Maskuri Jun 2025

Marketing Management Of Cemetery-Based Religious Sites To Improve The Economic Level Of Society, Dian Mohammad Hakim, Imam Wahyudi Karimullah, Winarto Winarto, Maskuri Maskuri

International Journal of Religious Tourism and Pilgrimage

This study discussed the potential of cemetery-based religious tourism as an economic development strategy, with the Sunan Ampel Cemetery in Surabaya, Indonesia, as a case in point. By analysing its marketing management strategies, the study demonstrates that successful tourism development requires more than just pulling in tourists; it requires an integrated approach that includes infrastructure and technology development, stakeholder collaboration, and local community involvement. With close to two million visitors each year, Sunan Ampel is an excellent example of the huge economic gains from successful religious tourism efforts. This paper emphasises the need to convert historical religious sites from passive …


Religious Tolerance Through Prayer: Legal Analysis And Inter-Religious Prayer Interactions Communities In Realising Religious Harmony, Zuli Dwi Rahmawati, Siti Sumadiyah Jun 2025

Religious Tolerance Through Prayer: Legal Analysis And Inter-Religious Prayer Interactions Communities In Realising Religious Harmony, Zuli Dwi Rahmawati, Siti Sumadiyah

International Journal of Religious Tourism and Pilgrimage

Joint prayer is an activity that is performed by different religious groups at the same time and place. This practice can be done in the form of one or several people praying while others agree, or everyone prays together according to their respective religions. In Indonesia, the practice of joint prayer shows a discourse on religious tolerance in the diversity of society. The practice of prayer between religious people often triggers discussions on pros and cons among Indonesian people. In this article the law and the interaction of prayer between religious communities as an effort to understand the key role …


Dark Tourism And ‘Partial Religiosity’: Ontological-Aesthetic Pilgrimage In Camiguin Island, Philippines, Jan Gresil Kahambing Jun 2025

Dark Tourism And ‘Partial Religiosity’: Ontological-Aesthetic Pilgrimage In Camiguin Island, Philippines, Jan Gresil Kahambing

International Journal of Religious Tourism and Pilgrimage

This paper theorizes the contrast between dark tourism and what is referred to as ‘partial religiosity’ in the context of travel to selected tourist destinations on Camiguin Island, Philippines. Also called ‘thanatourism’, dark tourism is about visiting places that challenge the value derived from the association with death either from tragedies of naturally occurring catastrophes (such as earthquakes, volcanic eruptions, or typhoons) or disasters produced by humans (such as genocides and violations of human rights). Focus is on three spots that sufficiently fit the description of dark tourist sites in Camiguin in the sense of naturally-caused disasters, namely: the Sunken …


Nostalgia, Trauma And Recovery: A Case Study Of Hazrat Hamza Shah Shrine, Ismail Rafik Shaikh, Subhash Kizhakanveatil Bhaskaran Pillai, Indrawati Indrawati, Irfan Syed Mirza, Yu-Fang Yen, Arina Khoirunnisa Jun 2025

Nostalgia, Trauma And Recovery: A Case Study Of Hazrat Hamza Shah Shrine, Ismail Rafik Shaikh, Subhash Kizhakanveatil Bhaskaran Pillai, Indrawati Indrawati, Irfan Syed Mirza, Yu-Fang Yen, Arina Khoirunnisa

International Journal of Religious Tourism and Pilgrimage

Religious tourism, as a pillar of spirituality and faith, continues to uplift and encourage believers in times of hardship. However, religious tourism was severely disrupted by the COVID-19 pandemic, which affected many stakeholders at different levels. This study explores the experiences of various stakeholders at the Hazrat Hamza Shah Shrine in Goa over three different time periods: nostalgia (before the pandemic), trauma (during the pandemic), and recovery (following the pandemic). Utilising qualitative data from interviews and social media sentiment analysis (53 posts on Facebook, 185 on Instagram, 64 on YouTube, and 102 on Google Maps), the study has identified a …


Mapping Of Religious Tourism And Pilgrimage Market: Study Of Selected Religious Locations In Goa, Parth Ravindra Rahalkar, Subhash Kizhakanveatil Bhaskaran Pillai, Indrawati Indrawati Jun 2025

Mapping Of Religious Tourism And Pilgrimage Market: Study Of Selected Religious Locations In Goa, Parth Ravindra Rahalkar, Subhash Kizhakanveatil Bhaskaran Pillai, Indrawati Indrawati

International Journal of Religious Tourism and Pilgrimage

This paper seeks to answers two basic research questions, firstly, how the COVID-19 pandemic impacted people with respect to religious tourism and pilgrimage, and secondly how the untapped potential for religious tourism and pilgrimage can be utilised in the future. Nine religious sites in Goa, India were selected purposively so a route map can be developed which becomes easy for making a one-day trip from North to South Goa and vice versa. These sites were assessed to identify the status of the five destination attributes. From each of these nine locations, four respondents were identified purposively [a resident, a visitor, …


Utility Of Carboxyhemoglobin Level For The Diagnosis Of Invasive Bacterial Infection In A Febrile Neonate At Paediatric Emergency Department, Abdulhamid Al Hinai, Laila Al Yazidi, Sanjay Jaju, Nasser Al Sidairi, Khalil Al Habsi, Mohammed Al Lawati, Saeed Al Obeidani Jun 2025

Utility Of Carboxyhemoglobin Level For The Diagnosis Of Invasive Bacterial Infection In A Febrile Neonate At Paediatric Emergency Department, Abdulhamid Al Hinai, Laila Al Yazidi, Sanjay Jaju, Nasser Al Sidairi, Khalil Al Habsi, Mohammed Al Lawati, Saeed Al Obeidani

Sultan Qaboos University Medical Journal

Objective: Carboxyhaemoglobin (COHb), which represents the fraction of carbon monoxide bound to haemoglobin, is available as a point-of-care test in the emergency department. This study aimed to assess the role of COHb in the diagnosis of invasive bacterial infections (IBI) in a paediatric emergency department. Methods: This retrospective study examined a single reading of venous COHb values in otherwise healthy neonates who presented with febrile illness at the paediatric emergency department at Royal Hospital, Muscat, Oman, between December 2019 and December 2022. The optimal COHb level for the diagnosis of IBI was determined using receiver operating characteristic curve …


Enhancing Delirium Prediction And Prevention In Elderly Patients Through Machine Learning-Based Analysis, Abdullah M. Al Alawi, Juhaina S. Al Maqbali Jun 2025

Enhancing Delirium Prediction And Prevention In Elderly Patients Through Machine Learning-Based Analysis, Abdullah M. Al Alawi, Juhaina S. Al Maqbali

Sultan Qaboos University Medical Journal

Objective: This study aimed to identify predictors of delirium within 24 hours of admission in elderly patients using machine learning (ML) models and evaluate their performance. Methods: This prospective cohort study was conducted among patients aged 65 years and older admitted to the general medical unit of Sultan Qaboos University Hospital, Muscat, Oman, from January 2022 to May 2023. Clinical and demographic data were collected and analysed using 4 ML models: logistic regression, random forest, gradient boosting and support vector machine. Model performance was evaluated using accuracy, precision, recall, F1 score and area under the curve-receiver operating characteristic …


Chest Wall Chondromyxoid Fibroma: A Case Report And Literature Review, Waad Al Farsi, Yaseen Al Lawati, Hilal Al Sabti, Zakiya Al Ajmi, Humaid Al Farii Jun 2025

Chest Wall Chondromyxoid Fibroma: A Case Report And Literature Review, Waad Al Farsi, Yaseen Al Lawati, Hilal Al Sabti, Zakiya Al Ajmi, Humaid Al Farii

Sultan Qaboos University Medical Journal

Chondromyxoid fibromas (CMFs) are rare tumours that comprise less than 2% of benign bone tumours; approximately 5-7.9% occur in the ribs. We report a 28-year-old female patient with CMF in the 4th rib that presented to a tertiary care hospital in Muscat, Oman, in 2023. She complained of pain in the right posterior chest wall for 6 months. A chest computed tomography showed posterior 4th rib expansile lesion measuring 3×2 cm without soft tissue involvement. A percutaneous biopsy suggested a diagnosis of chondomyxoid fibroma. The tumour was resected with a free-margin and assistance of video-assisted thoracic surgery approach. The diagnosis …


Integrated Metabolomics And Spatial Transcriptomics Of Cystic Pancreatic Cancer Precursors Reveals Dysregulated Polyamine Metabolism As A Biomarker Of Progression, Ricardo A León-Letelier, Yihui Chen, Rongzhang Dou, Ehsan Irajizad, Michele T Yip-Schneider, Ranran Wu, Rahmah Ejaz, Hamid K Rudsari, Yaxi Li, Rachelle Spencer, Riccardo Ballarò, Jody Vykoukal, Mark Hurd, Jennifer B Dennison, Kim-Anh Do, Anirban Maitra, Jianjun Zhang, Samir Hanash, C Max Schmidt, Johannes F Fahrmann Jun 2025

Integrated Metabolomics And Spatial Transcriptomics Of Cystic Pancreatic Cancer Precursors Reveals Dysregulated Polyamine Metabolism As A Biomarker Of Progression, Ricardo A León-Letelier, Yihui Chen, Rongzhang Dou, Ehsan Irajizad, Michele T Yip-Schneider, Ranran Wu, Rahmah Ejaz, Hamid K Rudsari, Yaxi Li, Rachelle Spencer, Riccardo Ballarò, Jody Vykoukal, Mark Hurd, Jennifer B Dennison, Kim-Anh Do, Anirban Maitra, Jianjun Zhang, Samir Hanash, C Max Schmidt, Johannes F Fahrmann

Faculty, Staff and Student Publications

Purpose: We conducted metabolomics and spatial cell transcriptomics of intraductal papillary mucinous neoplasms (IPMN), recognized pancreatic cancer precursors, to identify oncometabolites that inform upon risk of malignancy of IPMNs.

Experimental design: Untargeted metabolomic analyses were performed on cystic fluid from 125 patients with low-grade (LG) dysplasia or high-grade (HG) dysplasia with/without concurrent pancreatic ductal adenocarcinoma (PDAC; IPMN/PDAC). Predictive performance of individual metabolites for identifying HG or PDAC/IPMN was determined and compared with CA19-9 performance. Data were intersected with metabolic profiles of resected IPMN tissues and murine Kras;Gnas IPMN cell lines as well as spatial and single-cell transcriptomics of IPMNs.

Results: …