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Articles 99121 - 99150 of 2917849
Full-Text Articles in Entire DC Network
Nurturing Belonging: A Qualitative Study Of Participation In A Gardening Group For People Living With And Beyond Cancer, Melissa Jacobs, Kerryann Steele, Alison Warren
Nurturing Belonging: A Qualitative Study Of Participation In A Gardening Group For People Living With And Beyond Cancer, Melissa Jacobs, Kerryann Steele, Alison Warren
School of Health Professions
PurposeThe incidence of cancer is increasing globally and engagement in meaningful occupations is fundamental for people living with and beyond cancer. There is a growing body of evidence regarding the health and well-being benefits of engaging in nature-based occupations, however, there is limited evidence specific to this population. This study aims to explore the experiences of engaging in Blooming Well, a gardening group created to provide opportunities for people recovering from or living with cancer.Design/methodology/approachA qualitative case study methodology was used to explore perspectives of both group leaders and participants of the Blooming Well group. Study participants included two group …
Mapping Vascular Network Architecture In Primate Brain Using Ferumoxytol-Weighted Laminar Mri, Joonas A Autio, Ikko Kimura, Takayuki Ose, Yuki Matsumoto, Masahiro Ohno, Yuta Urushibata, Takuro Ikeda, Matthew F Glasser, David C Van Essen, Takuya Hayashi
Mapping Vascular Network Architecture In Primate Brain Using Ferumoxytol-Weighted Laminar Mri, Joonas A Autio, Ikko Kimura, Takayuki Ose, Yuki Matsumoto, Masahiro Ohno, Yuta Urushibata, Takuro Ikeda, Matthew F Glasser, David C Van Essen, Takuya Hayashi
2020-Current year OA Pubs
Mapping the vascular organization of the brain is of great importance across various domains of basic neuroimaging research, diagnostic radiology, and neurology. However, the intricate task of precisely mapping vasculature across brain regions and cortical layers presents formidable challenges, resulting in a limited understanding of neurometabolic factors influencing the brain's microvasculature. Addressing this gap, our study investigates whole-brain vascular volume using ferumoxytol-weighted laminar-resolution multi-echo gradient-echo imaging in macaque monkeys. We validate the results with published data for vascular densities and compare them with cytoarchitecture, neuron and synaptic densities. The ferumoxytol-induced change in transverse relaxation rate (ΔR
Georgia Has A New Habitability Protection For Tenants, But What Does It Mean?, Elizabeth Grant, Gordon Wayne
Georgia Has A New Habitability Protection For Tenants, But What Does It Mean?, Elizabeth Grant, Gordon Wayne
Scholarly Works
Georgia’s Safe at Home Act became law on July 1, 2024, and established the standard that residential premises be “fit for human habitation.” The Act strengthens tenant protections by targeting severe housing issues affecting 15% of Georgia households, particularly Black and rural communities. It adds cooling as an essential utility, caps security deposits, and mandates a three-day notice to pay before eviction filings. However, the undefined “fit for human habitation” term awaits judicial interpretation, complicated by limited legal access and rare appellate precedent. Though a key step forward, this brief Comment suggests that additional measures are needed to secure tenants’ …
Morphological And Physiological Responses Of Cymbopogon Citratus And Pennisetum Alopecuroides To Saline Water Irrigation, Haifeng Xing, Asmita Paudel, Julie Hershkowitz, Youping Sun
Morphological And Physiological Responses Of Cymbopogon Citratus And Pennisetum Alopecuroides To Saline Water Irrigation, Haifeng Xing, Asmita Paudel, Julie Hershkowitz, Youping Sun
Plants, Soils, and Climate Faculty Publications
Reclaimed water provides a sustainable and economical alternative for landscape irrigation, but its elevated salinity can negatively impact sensitive plant species. This study evaluated the salinity tolerance of two widely used ornamental grasses, Cymbopogon citratus (lemon grass) and Pennisetum alopecuroides (fountain grass), under three electrical conductivity (EC) levels: 1.2 (control), 5.0, and 10.0 dS·m−1. Visual assessments over 62 days showed that both species maintained an acceptable appearance under saline conditions. C. citratus exhibited no foliar damage, with visual scores above 4.6 even at 10.0 dS·m−1, whereas P. alopecuroides showed slight leaf injury but retained a score …
Modernism’S Mythic Mothers: Queering Motherhood Through Classical Matrilineage, Samantha Marie Lepak
Modernism’S Mythic Mothers: Queering Motherhood Through Classical Matrilineage, Samantha Marie Lepak
Dissertations
I position this dissertation at the intersection of modern/contemporary literature, queer/feminist theory, and ancient Greek classics in the hopes of better understanding the spaces in which they meet, engaging with writers from the late modernist era to the present in order to highlight the connections between theories, themes, and practices of queerness from the modernists forward. Using the work of H.D. and writers following in her footsteps, I argue that exploring adaptations of Greek classics written primarily by female and gender-variant authors from the modernist era forward illuminates the extent to which the classics enables writers to “think queerly,” considering …
Maternal Access For Depression In Rural Environments, Simone Parlier
Maternal Access For Depression In Rural Environments, Simone Parlier
Dissertations
Significance –As many as 25% of birthing persons experience postpartum depression (PPD) within the first year after childbirth making this one of the most common postpartum disorders. PPD is prevalent, incapacitating, and treatable. The first step is identifying those at risk. Rural birthing persons are understudied, and may have unique predisposing characteristics as well as geographic challenges for optimal detection and treatment of PPD. Purpose -The long-term goal is to improve the health of rural families. Using The Theory of Unpleasant Symptoms, the purpose of this descriptive, cross-sectional research was to describe the prevalence of PPD in rural birthing persons …
Ethnicity Through Education: An Analysis Of The Influence Of Formal Education On Ethnicity In Garo Hills, Samirkumar Benedict Talati
Ethnicity Through Education: An Analysis Of The Influence Of Formal Education On Ethnicity In Garo Hills, Samirkumar Benedict Talati
Dissertations
In recent decades, the positioning of ethnic groups within the educational context has emerged as an important area of scholarly investigation. The structural, institutional, and local contexts often determine how ethnic groups shape their ethnicity. This study draws from panethnicity and social ontology frameworks to examine ethnic consciousness and the processes of solidarity-building across subgroups within the Garo community in the Garo Hills of Meghalaya. The unequal distribution of educational resources has led to socioeconomic disparities and class formation within Garo society, creating a growing divide between the educated and uneducated Garos. While acknowledging the diversity among subgroups, this study …
Assessment Of Relationships Between Quality And Staffing In The Ambulatory Care Environment, Rachel E. Start
Assessment Of Relationships Between Quality And Staffing In The Ambulatory Care Environment, Rachel E. Start
Dissertations
ABSTRACT Background The United States healthcare system underperforms compared to other industrialized countries where cost and quality are concerned. Nursing is accountable, as a profession recognized by society, to ensure health and livelihood in the patients and populations served. Advancing the role of the ambulatory care nurse and providing valid strategies to measure the contribution of the nursing profession in this setting is a tactic that many organizations are pursuing to achieve this paradigm shift. The assessment of relationships between measures of structure, process, and outcome within the ambulatory care setting across a variety of organizations may have the potential …
Exploring Latinx Students' Experience With School Connectedness: A Hybrid Thematic Approach To Deductive And Inductive Analysis, Maria Olivia Mendez
Exploring Latinx Students' Experience With School Connectedness: A Hybrid Thematic Approach To Deductive And Inductive Analysis, Maria Olivia Mendez
Dissertations
This qualitative study aimed to deepen the understanding of school connectedness experienced by Latinx high school students. Specifically, the researcher sought to explore how Latinx students described their connection to school during their high school years. Additionally, to examine whether their experiences aligned with the social and ecological structures outlined in the theoretical model supporting adolescent connectedness to school. If there is alignment, in what ways did it manifest? If not, how did the experiences differ? The study had two primary objectives: (a) to gain insight into how Latinx students experienced school and their sense of connection through their narratives, …
Family Matters: Experiences Of Family Stigma, Addiction Recovery & The Role Of Self-Compassion, Kennedy Hoying
Family Matters: Experiences Of Family Stigma, Addiction Recovery & The Role Of Self-Compassion, Kennedy Hoying
Master's Theses
Addiction and substance use is currently one of the most stigmatized disorders in society, creating a barrier to treatment and recovery. This study explored the role of family stigma, the stigmatization processes of family members of otherwise stigmatized individuals, within families of substance users to examine how stigma might affect family support behaviors. Two hundred and twenty-two U.S. adults who have a substance using family member completed an online survey regarding their experiences of family stigma, attributions of responsibility for addiction, self-compassion, and any supportive recovery behaviors they engage in to help their family member’s addiction. Results of correlation analysis …
Anthropogenic Litter In Freshwater Ecosystems: Effect On Ecosystem Processes And Spatial Distribution, Emily Johnson
Anthropogenic Litter In Freshwater Ecosystems: Effect On Ecosystem Processes And Spatial Distribution, Emily Johnson
Master's Theses
The rapid increase of plastic production and disposal into the environment has resulted in anthropogenic litter (i.e., trash; AL) becoming a global problem. In aquatic ecosystems, macro- and microplastics are long-lived, mobile, and interact with the physical and chemical components of aquatic ecosystems. Our objectives were to: (1) assess the impact of microplastic pollution on the ecosystem processes of ecosystem metabolism and N2 flux in an oligotrophic lake and (2) to assess the abundance and assemblage of anthropogenic litter in a large urban river. For objective (1), we added microplastics at a range of concentrations to littoral mesocosms. Ecosystem metabolism …
Working Paper No. 101, “Universal Welfare” In Marxist Thought, And Its Implementation During The Era Of The Soviet Union, Eunji Jang
Working Papers in Economics
This inquiry seeks to establish that although in his writings Karl Marx emphasized “Universal Welfare” as a central ideal, its appearance and realization in the Soviet Union was affected by tensions between ideology and the realities of centralized economic control. The first section explores Marx’s vision of universal welfare as a structural component of a post-capitalist society rooted in collective ownership and human emancipation. The second section examines how the Soviet Union institutionalized welfare across sectors such as education, healthcare, housing, and employment, while access to these services was often influenced by labor contribution and political loyalty. The final section …
Inactivation Of The Fusobacterium Nucleatum Rnf Complex Reduces Fada-Mediated Amyloid Formation And Tumor Development, Timmie A Britton, Ju Huck Lee, Chungyu Chang, Aadil H Bhat, Yi-Wei Chen, Rusul Mohammed Ali, Chenggang Wu, Asis Das, Hung Ton-That
Inactivation Of The Fusobacterium Nucleatum Rnf Complex Reduces Fada-Mediated Amyloid Formation And Tumor Development, Timmie A Britton, Ju Huck Lee, Chungyu Chang, Aadil H Bhat, Yi-Wei Chen, Rusul Mohammed Ali, Chenggang Wu, Asis Das, Hung Ton-That
Faculty, Staff and Student Publications
The Gram-negative anaerobe Fusobacterium nucleatum is an oral oncobacterium that promotes colorectal cancer (CRC) development with the amyloid-forming cell surface adhesin FadA integral to CRC tumorigenesis. We describe here molecular genetic studies uncovering a novel mode of metabolic regulation of FadA-mediated tumor formation by a highly conserved respiratory enzyme known as the Rnf complex. First, we show that genetic disruption of Rnf, via rnfC deletion, significantly reduces the level of fadA transcript, accompanied by a near-complete abolishment of the precursor form of FadA (pFadA), reduced assembly of FadA at the mature cell pole, and severe defects in the osmotic stress-induced …
Green Technologies For Isolating Bioactives From Plant-Based Food And Their Applications In Human Health And Longevity, Vibha Gajbe, Azza S. Naik, Roji Waghmare, Shuchi Midha
Green Technologies For Isolating Bioactives From Plant-Based Food And Their Applications In Human Health And Longevity, Vibha Gajbe, Azza S. Naik, Roji Waghmare, Shuchi Midha
Research Outputs: 2025-Present
No abstract provided.
Organizational Development At Milner Library: A Journey Of Transformation 2024-2025, Chloe Vicente, Susan Franzen
Organizational Development At Milner Library: A Journey Of Transformation 2024-2025, Chloe Vicente, Susan Franzen
Reports and White Papers - Milner Library
This presentation was delivered at Milner Library on June 11, 2025 by Chloe Vicente, Fulbright Scholar-in-Residence, and Sue Franzen, Associate Dean of Public Services and Organizational Development.
Christian Beliefs About Salvation: Measurement And Associations With Mental Health And Well-Being, Anthony Edward Rose, Timothy B. Smith
Christian Beliefs About Salvation: Measurement And Associations With Mental Health And Well-Being, Anthony Edward Rose, Timothy B. Smith
Faculty Publications
Religious beliefs influence many behaviors and perspectives relevant to wellbeing and mental health. In Christianity, beliefs about how one attains salvation may be particularly relevant to psychology, but limited scholarship has considered cognitive aspects of religiosity. This study developed and evaluated a new measure of Beliefs about Salvation (BAS) that assesses affirmations of salvation (a) by God’s grace alone and (b) by God’s grace after human repentance/ordinances, as understood by different Christian denominations. We examined the association of the BAS with three measures of mental health and six measures of influences on religiosity. In a sample of 1556 predominantly members …
Egr3 Deletion Rescues Developmental And Epileptic Encephalopathy In Kcna1-Null Mice, Arindam Ghosh Mazumder, Saifina Karedia, Nandani Adhyapak, Catharina Schimer, John Samuel Bass, Jessica L Kamen, Miranda J Jankovic, Qinglong Miao, Amelia L Gallitano, Alexander B Saltzman, Antrix Jain, Anna Malovannaya, Edward Glasscock, Isamu Aiba, Jeffrey L Noebels, Vaishnav Krishnan
Egr3 Deletion Rescues Developmental And Epileptic Encephalopathy In Kcna1-Null Mice, Arindam Ghosh Mazumder, Saifina Karedia, Nandani Adhyapak, Catharina Schimer, John Samuel Bass, Jessica L Kamen, Miranda J Jankovic, Qinglong Miao, Amelia L Gallitano, Alexander B Saltzman, Antrix Jain, Anna Malovannaya, Edward Glasscock, Isamu Aiba, Jeffrey L Noebels, Vaishnav Krishnan
Faculty, Staff and Students Publications
KCNA1 encodes the α-subunit of the voltage-gated potassium channel KV1.1. Mutations in KV1.1’s pore domain result in developmental and epileptic encephalopathy (DEE), where early life seizures and a culprit lesion synergistically disrupt neurodevelopmental trajectories, resulting in intellectual disability that often presents with disturbances in sleep, sociability and sensory processing. Abnormalities in the subcellular localization of Kv1.1, via mutations in/autoantibodies against LGI1 and CNTNAP2, also give rise to syndromes of epilepsy and neuropsychiatric impairment. Mice with deletions of Kcna1(“−/−“) display spontaneous seizures at 2–3 weeks of age and premature mortality. In this study, we applied instrumented home-cage monitoring to examine …
Citrullinated Eno1 Vaccine Enhances Pd-1 Blockade In Mice Implanted With Murine Triple-Negative Breast Cancer Cells, Ricardo A León-Letelier, Alejandro M Sevillano-Mantas, Yihui Chen, Soyoung Park, Jody Vykoukal, Johannes F Fahrmann, Edwin J Ostrin, Candace Garrett, Rongzhang Dou, Yining Cai, Fu-Chung Hsiao, Jennifer B Dennison, Eduardo Vilar, Banu K Arun, Samir Hanash, Hiroyuki Katayama
Citrullinated Eno1 Vaccine Enhances Pd-1 Blockade In Mice Implanted With Murine Triple-Negative Breast Cancer Cells, Ricardo A León-Letelier, Alejandro M Sevillano-Mantas, Yihui Chen, Soyoung Park, Jody Vykoukal, Johannes F Fahrmann, Edwin J Ostrin, Candace Garrett, Rongzhang Dou, Yining Cai, Fu-Chung Hsiao, Jennifer B Dennison, Eduardo Vilar, Banu K Arun, Samir Hanash, Hiroyuki Katayama
Faculty, Staff and Student Publications
Background/Objectives:Cancer vaccine targets mostly include mutations and overexpressed proteins. However, cancer-associated post-translational modifications (PTMs) may also induce immune responses. Previously, our group established the enzyme protein arginine deiminase type-2 (PADI2), which catalyzes citrullination modification, is highly expressed in triple-negative breast cancer (TNBC), promoting antigenicity.
Methods: Here, we show the workflow of designing citrullinated enolase 1 (citENO1) vaccine peptides identified from breast cancer cells by mass spectrometry and demonstrate TNBC vaccine efficacy in the mouse model. Immunized mice with citENO1 peptides or the corresponding unmodified peptides, plus Poly I:C as an adjuvant, were orthotopically implanted with a TNBC murine …
Nafld Surveillance In The Alaska Native/American Indian Population, Wileina Saumara Rhodes
Nafld Surveillance In The Alaska Native/American Indian Population, Wileina Saumara Rhodes
Walden Dissertations and Doctoral Studies
In the United States, the prevalence of NAFLD is estimated at 24% of the population, and by 2030, the incidence of NAFLD will increase to 100.9 million cases. This study aimed to determine the prevalence and rate of non-alcoholic fatty liver disease (NAFLD) progression in the Alaska Native/ American Indian population (AN/AI) with and without elevated liver function tests. Two research questions guided the study: Do outcomes (abnormal/normal) of LFTs, A1C, lipids, BMI, and inflammatory markers predict or have a relationship with NAFLD progression? Does NAFLD surveillance have a relationship with the patient’s outcome as measured by the NAFLD Fibrosis …
Crisis Management Strategies For Sustaining Small Business Operations And Profitability During Unexpected Events, Dr. Brandy Marie Jones
Crisis Management Strategies For Sustaining Small Business Operations And Profitability During Unexpected Events, Dr. Brandy Marie Jones
Walden Dissertations and Doctoral Studies
Small business leaders face financial and logistical challenges during crises, such as economic downturns, natural disasters, and supply chain disruptions. This issue is critical for small business owners and policymakers, as effective crisis management ensures economic stability and community resilience. Grounded in situational crisis communications theory, the purpose of this qualitative pragmatic inquiry was to identify and explore effective crisis management strategies that small business leaders use to remain operational and profitable during unexpected events. The participants were seven small business leaders in Dallas, Texas who used effective crisis management strategies to remain profitable during unexpected events. Datum was collected …
Digital Transformation Strategies Used By Church Leaders To Increase Revenues And Meet Budgetary Goals, Lee Riley
Walden Dissertations and Doctoral Studies
Ineffective strategies to use digital transformation to increase revenues and meet budgetary goals can negatively impact small rural church leadership capabilities. Small rural church leaders who struggle to increase revenues and meet budgetary goals are at high risk of business instability. Grounded in the diffusion of innovations theory, the purpose of this qualitative pragmatic inquiry was to identify and explore effective digital transformation strategies used by small rural church leaders to increase revenues and meet budgetary goals. Participants were eight small rural church leaders who had effectively used digital transformation to increase revenues and meet budgetary goals. Data were collected …
Nonprofit Marketing Strategies To Target A Specific Client Population, Daniel Curtis Grant
Nonprofit Marketing Strategies To Target A Specific Client Population, Daniel Curtis Grant
Walden Dissertations and Doctoral Studies
African American females are the fastest-growing demographic in the United States contracting HIV. Nonprofit executives are concerned that, without effective marketing campaigns, African American females are not seeking the education or testing proven to reduce the chance of contracting HIV. Grounded in the integrated marketing communications theory, the purpose of this qualitative single case study was to explore strategies that nonprofit executives use to design and execute effective marketing campaigns targeted to a specific client population. The participants were four senior leaders from a nonprofit healthcare clinic located in the south-central Region of the United States who have 10 or …
Leadership Strategies To Enhance Funding Performance In Pre-K -12 Public School Districts, Cynthia W. Williams Jones
Leadership Strategies To Enhance Funding Performance In Pre-K -12 Public School Districts, Cynthia W. Williams Jones
Walden Dissertations and Doctoral Studies
Some school leaders lack strategies to impact educational funding performance in prekindergarten through 12th grade (PK-12) public schools and increase students’ academic achievement and performance. School leaders and policymakers are concerned with improving educational funding, student achievement, and student performance in PK-12 public schools. Grounded in the Baldrige excellence framework, the purpose of this qualitative pragmatic inquiry study was to identify effective strategies that school leaders use to improve educational funding performance in PK-12 public schools and increase students’ academic achievement and performance. Participants were six PK-12 public school leaders with at least 5 years of leadership experience who had …
Strategies For Reducing Cost Overruns On Government-Funded Infrastructure Projects In Jamaica, Owen Whitely
Strategies For Reducing Cost Overruns On Government-Funded Infrastructure Projects In Jamaica, Owen Whitely
Walden Dissertations and Doctoral Studies
Cost overruns involving government-funded infrastructure projects have the potential to lead to adverse economic and social outcomes. Project managers and government administrators are concerned with cost overruns as they often lead to delays, resource misallocation, and decreased public trust. Grounded in the theory of constraints, the purpose of this qualitative pragmatic inquiry was to explore strategies project managers use to reduce cost overruns for government-funded infrastructure projects in Jamaica. Participants were five project managers working on large-scale infrastructure projects with experience effectively mitigating cost overruns in Jamaica. Data were collected through in-depth semistructured interviews, government documents, and public records. Five …
Role Of Glucuronoxylomannan And Steryl Glucosides In Protecting Against Cryptococcosis, Gabriel Soares Matos, Tamara L Doering, Et Al.
Role Of Glucuronoxylomannan And Steryl Glucosides In Protecting Against Cryptococcosis, Gabriel Soares Matos, Tamara L Doering, Et Al.
2020-Current year OA Pubs
The development of vaccines for fungal diseases, including cryptococcosis, is an emergent line of research and development. In previous studies, we showed that a
Registered Nurses’ Perceptions Of Patient Safety In Critical Care Units, Martha Benghie Hyacinthe
Registered Nurses’ Perceptions Of Patient Safety In Critical Care Units, Martha Benghie Hyacinthe
Walden Dissertations and Doctoral Studies
Patient safety is a cornerstone of effective healthcare delivery, particularly in critical care units (CCUs) where patients are at heightened risk of complications due to their complex medical conditions. The purpose of this study, guided by Watson’s theory of human caring, was to explore RNs’ perceptions of patient safety in CCUs. Data on eight RNs working in CCUs were collected through semi-structured interviews, allowing for an in-depth exploration of nurses’ perspectives. Data were collected through semi-structured interviews, allowing for an in-depth exploration of nurses’ perspectives. Using Saldana’s method of thematic analysis, three overarching themes emerged: patient safety, resource allocation, and …
Psychiatric Boarding Discharge Strategies That Improve Service Quality And Throughput In Emergency Departments, Dr. Charille Caldwell
Psychiatric Boarding Discharge Strategies That Improve Service Quality And Throughput In Emergency Departments, Dr. Charille Caldwell
Walden Dissertations and Doctoral Studies
A lack of effective psychiatric discharge process strategies affects the service quality, throughput efficiency, and revenue of emergency departments (EDs). Consequently, ED discharge coordinators are concerned about the significant financial losses from these deficiencies. The purpose of this multiple qualitative descriptive case study was to explore discharge strategies ED discharge coordinators used to improve service quality and throughput of psychiatric-boarded patients in ERs by reducing the number of psychiatric-boarded patients' length of stay (LOS). The Donabedian model grounded this study. The participants were three ED discharge coordinators in the United States who successfully implemented such strategies. Data were collected from …
The Parthenon, June 11, 2025, Baylee Parsons, Kaitlyn Fleming, Ashton Pack, Nate Harrah, Soleil Woolard
The Parthenon, June 11, 2025, Baylee Parsons, Kaitlyn Fleming, Ashton Pack, Nate Harrah, Soleil Woolard
The Parthenon
No abstract provided.
Increasing Global South Knowledge Representation With Oa And Library Resource Sharing, J. Silvia Cho
Increasing Global South Knowledge Representation With Oa And Library Resource Sharing, J. Silvia Cho
Publications and Research
In this peer-review session, I present ideas to study and overcome barriers to digital interlibrary loan exchange with Latin America under Fair Use (and equivalent provisions). Materials published in Latin America and the Caribbean are more difficult to discover and access from the United States, creating silos and under-representation of points of view from these regions in Global North scholarship. Open Access is key towards overcoming barriers to access, but much of Southern knowledge continues to be in non-Open Access publications with traditional copyright. As a result, library resource sharing and interlibrary loan must facilitate a greater flow of Southern …
Parallel Use Of Low-Complexity Automated Nucleic Acid Amplification Tests On Respiratory And Stool Samples With Or Without Lateral Flow Lipoarabinomannan Assays To Detect Pulmonary Tuberculosis Disease In Children, Laura Olbrich, Bada Yang, Hayley Poore, Alia Razid, Brittney Sweetser, Mathias Weis Damkjær, Alexander W Kay, Johanna Åhsberg, Ruvandhi R Nathavitharana, Ian Schiller, Nandini Dendukuri, Andreas Lundh, Maunank Shah, Stephanie Bjerrum, Devan Jaganath
Parallel Use Of Low-Complexity Automated Nucleic Acid Amplification Tests On Respiratory And Stool Samples With Or Without Lateral Flow Lipoarabinomannan Assays To Detect Pulmonary Tuberculosis Disease In Children, Laura Olbrich, Bada Yang, Hayley Poore, Alia Razid, Brittney Sweetser, Mathias Weis Damkjær, Alexander W Kay, Johanna Åhsberg, Ruvandhi R Nathavitharana, Ian Schiller, Nandini Dendukuri, Andreas Lundh, Maunank Shah, Stephanie Bjerrum, Devan Jaganath
Faculty, Staff and Students Publications
Background: Low-complexity automated nucleic acid amplification tests (LC-aNAATs) are molecular assays widely used to diagnose tuberculosis disease in children. The lateral flow urine lipoarabinomannan assay (LF-LAM) is recommended for use amongst children with HIV. Previous systematic reviews have assessed the diagnostic accuracy of LC-aNAATs and LF-LAM separately in children, but in clinical practice the tests may be used concurrently, i.e. in 'parallel'.
Objectives: To compare the diagnostic accuracy of the parallel use of LC-aNAAT on respiratory and stool specimens in children, and with LF-LAM on urine amongst children with HIV, versus each assay alone for detecting pulmonary tuberculosis disease.
Search …