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Articles 98431 - 98460 of 2929955
Full-Text Articles in Entire DC Network
Retraction: A Database Of Teleseismic Shear-Wave Splitting Measurements For The Ordos Block And Adjacent Areas(Seismological Research Letters (2022), 93, 5, (2731–2739), 10.1785/0220210310), Lin Liu, Stephen S. Gao, Kelly H. Liu, Tu Xue, Yan Jia, Sanzhong Li
Retraction: A Database Of Teleseismic Shear-Wave Splitting Measurements For The Ordos Block And Adjacent Areas(Seismological Research Letters (2022), 93, 5, (2731–2739), 10.1785/0220210310), Lin Liu, Stephen S. Gao, Kelly H. Liu, Tu Xue, Yan Jia, Sanzhong Li
Geosciences and Geological and Petroleum Engineering Faculty Research & Creative Works
An earlier version of this article (Liu et al., 2022) included private data from the Himalayan-III program which should not have been made public. The authors acknowledge and regret their negligence during the selection of the measurements. The impacted data represent only 2.7% of the total data published in this article, and after review, the authors and the editors agree that this unintentional error has no bearing on the work's scientific conclusions. Therefore, we are retracting the impacted data and have made corrections to remove any Himalayan-III program data from the article's text, figures, and supplemental tables.
Analyzing Google Maps As A Data Source For Urban Research In Dhaka, Xinyi Du
Analyzing Google Maps As A Data Source For Urban Research In Dhaka, Xinyi Du
Dissertations and Theses Collection (Open Access)
This paper investigates how mass transit infrastructure shapes urban economic activity by examining the impact of Dhaka's first metro line using novel Google Maps data. Leveraging the opening of Metro Line 6 on December 2022, we employ a difference-in-differences framework to analyze changes in business establishment density around metro stations. Our estimates show that every 1% reduction in distance to the nearest metro station adds, on average, about 0.092–0.111 establishments per 40 m × 40 m grid cell—that is, roughly 57 – 69 additional businesses per square kilometer. The effect is even more pronounced for dining: about 1 – 4 …
Machine Learning For Digital Biomarker-Based Detection Of Cognitive Decline, Seng Khoon The
Machine Learning For Digital Biomarker-Based Detection Of Cognitive Decline, Seng Khoon The
Dissertations and Theses Collection (Open Access)
Dementia is a neurodegenerative disease with a prevalence rate expected to triple by 2050, posing a significant challenge for health services. To impede the increasing prevalence, medical professionals and scientists are actively investigating technology to detect cognitive decline at a reversible stage known as Mild Cognitive Impairment (MCI). Digital biomarker technology is an emerging pragmatic approach to permit objective, ecologically valid, and long-term continuous measurement of cognitive health status, rendering it as one of the promising technologies for early MCI detection. Despite its potential, it is nontrivial to encode, extract and combine predictive information from these digital biomarker technologies; advanced …
Supporting On Their Own Terms: Eu Institutions’ Discourses On Mindanao, Vincent Carlo A. Legara
Supporting On Their Own Terms: Eu Institutions’ Discourses On Mindanao, Vincent Carlo A. Legara
European Studies Department Faculty Publications
This paper critically examines the nature and dynamics of European Union (EU) engagement in Mindanao. The southern Philippines is historically home to Muslims, with a special region that is the Bangsamoro Autonomous Region of Muslim Mindanao (BARMM), formerly known as the Autonomous Region in Muslim Mindanao, where Muslims compose the majority of the population. Muslim Mindanao gained greater autonomy in 2019 after decades of violent conflict and the persistence of weak democratic institutions. Since the 1970s, Muslim secessionist movements have clashed against government troops for independence. These have contributed to poor human development indicators in Mindanao. The EU, previously the …
Does External Labour Market Activeness Affect Agency Problem?, Yuyun Claudie Huang, Jamie Yixing Tong, Joey W. Yang
Does External Labour Market Activeness Affect Agency Problem?, Yuyun Claudie Huang, Jamie Yixing Tong, Joey W. Yang
Research outputs 2022 to 2026
This study examines the relationship between external labour market and the agency problem. Exploiting the staggered recognition of the Inevitable Disclosure Doctrine (IDD) by US state courts to capture a drop in external labour market activeness, we examine whether and how the activeness of external labour market affects managers' empire building behaviour. We find that in IDD-recognising states, managers are less engaged in empire-building activity, thus reducing agency costs and improving firm performance. The effect is concentrated in managers with heightened career concern where their firms experience higher degrees of financial constraints or operate within an industry of more intense …
Eco-Friendly Additives For Biodegradable Polyesters: Recent Progress In Performance Optimization And Environmental Impact Reduction, Ahmad Fayyazbakhsh, Nima Hajinajaf, Hamed Bakhtiari, Michael Feuchter, Ilaria Improta, Ehsan Salehi, Sara Kamal Shahsavar, Marketa Julinova, Amirehsan Ghasemi, Bita Ghasemi, Reza Afsharnia, Marek Koutný, Young Cheol Chang
Eco-Friendly Additives For Biodegradable Polyesters: Recent Progress In Performance Optimization And Environmental Impact Reduction, Ahmad Fayyazbakhsh, Nima Hajinajaf, Hamed Bakhtiari, Michael Feuchter, Ilaria Improta, Ehsan Salehi, Sara Kamal Shahsavar, Marketa Julinova, Amirehsan Ghasemi, Bita Ghasemi, Reza Afsharnia, Marek Koutný, Young Cheol Chang
Research outputs 2022 to 2026
Biodegradable polymers have emerged as principal alternatives to petroleum-based polymers, which exert a detrimental impact on the environment. Among these, biodegradable polyesters stand out as particularly noteworthy, renowned for their exceptional properties that find application across diverse industries, including food packaging, biomedical devices, and agriculture. This comprehensive analysis delves into the impact of various additives, with a focus on eco-friendly ones, on biodegradable polyesters, as evidenced by recent research endeavors. The additives are systematically categorized to provide a nuanced understanding within distinct industrial contexts. In the exploration of these additives, a meticulous classification is employed, ensuring a focused analysis of …
Atypical Beta Oscillatory Dynamics Are Related To Poor Procedural Learning In Children With Developmental Coordination Disorder, Jarrad A.G. Lum, Kaila M. Hamilton, Li Ann Leow, Welber Marinovic, Ian Fuelscher, Pamela Barhoun, Talitha C. Ford, Aron T. Hill, Samaneh Nahravani, Melissa Kirkovski, Peter G. Enticott, Christian Hyde
Atypical Beta Oscillatory Dynamics Are Related To Poor Procedural Learning In Children With Developmental Coordination Disorder, Jarrad A.G. Lum, Kaila M. Hamilton, Li Ann Leow, Welber Marinovic, Ian Fuelscher, Pamela Barhoun, Talitha C. Ford, Aron T. Hill, Samaneh Nahravani, Melissa Kirkovski, Peter G. Enticott, Christian Hyde
Research outputs 2022 to 2026
Procedural learning difficulties are commonly reported in children with developmental coordination disorder (DCD), yet the neural basis of this impairment remains unclear. This study addressed this gap by examining the correlation between cortical oscillatory activity and procedural learning of a sequence of finger movements in children with and without DCD. Participants were 19 children with DCD and 38 typically developing (TD) children, with a mean age of 10 years and 3 months. Children completed the Serial Reaction Time task, a standard measure of procedural learning, during which they unintentionally learned a sequence of finger movements. Electroencephalography (EEG) was continuously recorded …
Advanced Biodegradable Antimicrobial Coatings By Combining Biopolymers And Natural Antimicrobials For The Active Packaging And Extending The Shelf-Life Of Fish And Other Seafood Products: A Review, Hariharan S. Melarcode, Onur Ertugrul, Paola C. Alzate Calderon, Joseph P. Kerry, Michael A. Morris
Advanced Biodegradable Antimicrobial Coatings By Combining Biopolymers And Natural Antimicrobials For The Active Packaging And Extending The Shelf-Life Of Fish And Other Seafood Products: A Review, Hariharan S. Melarcode, Onur Ertugrul, Paola C. Alzate Calderon, Joseph P. Kerry, Michael A. Morris
Research Outputs: 2025-Present
Fish and other seafood products are an integral and valuable part of human diets. In advanced nations, the transportation of fish and other seafood products to customers requires packaging and display. Due to their intrinsic physicochemical properties, seafood products are particularly susceptible to microbial growth, resulting in shorter shelf lives and higher spoilage rates compared to other animal-derived proteins, such as meat. To prevent microbial spoilage and preserve the freshness and quality of fish and other seafood products, petroleum-based plastic materials are commonly used in combination with packaging technologies, such as vacuum packaging and modified atmosphere packaging. However, as these …
Understanding Perceptions, Attitudes And Experiences Of Nursing Students During Clinical Placement In Primary Health Care Settings – A Scoping Review, Debbie Procter, Kylie Mccullough, Debbie Massey, Karen Strickland
Understanding Perceptions, Attitudes And Experiences Of Nursing Students During Clinical Placement In Primary Health Care Settings – A Scoping Review, Debbie Procter, Kylie Mccullough, Debbie Massey, Karen Strickland
Research outputs 2022 to 2026
Aims: Critically analyse literature on undergraduate nursing students' perceptions, attitudes and experiences during Primary Health Care (PHC) placements and identify factors influencing their satisfaction. These insights may improve educational outcomes, shape career intentions and address workforce shortages. Background: Global nursing shortage, driven by increased demands and high attrition, impacts healthcare worldwide. Australia faces projected shortfalls of 79,473 nurses by 2035, significantly in PHC. Attributing factors include remuneration disparities, inadequate training/mentorship and limited career pathways. Strengthening the PHC nursing workforce is crucial, with undergraduate nursing students providing an important workforce pipeline. Design/Method: Scoping Review protocol was registered using Joanna Briggs Institute's …
Incorporating Waste Plastics Into Pavement Materials: A Review Of Opportunities, Risks, Environmental Implications, And Monitoring Strategies, Ali Ghodrati, Nuha S. Mashaan, Themelina Paraskeva
Incorporating Waste Plastics Into Pavement Materials: A Review Of Opportunities, Risks, Environmental Implications, And Monitoring Strategies, Ali Ghodrati, Nuha S. Mashaan, Themelina Paraskeva
Research outputs 2022 to 2026
The integration of waste plastics into pavement materials offers a dual benefit of enhancing road performance and mitigating the environmental burden of plastic waste. This review critically examines the opportunities and challenges associated with incorporating waste plastics in pavement construction, with an emphasis on their impact on the mechanical properties, durability, and life cycle performance of pavements. Special attention is given to the environmental implications, particularly the potential generation and release of micro- and nano-plastics during the pavement life cycle. This paper further evaluates current monitoring and analytical methodologies for detecting plastic emissions from road surfaces and explores emerging approaches …
Amyloid Accumulation, Brain Atrophy, And Cognitive Decline In Emergent Alzheimer's Disease, Ying Xia, Pierrick Bourgeat, Vincent Doré, Jurgen Fripp, Yen Ying Lim, Simon M. Laws, Christopher Fowler, Christopher C. Rowe, Colin L. Masters, Elizabeth J. Coulson, Paul Maruff
Amyloid Accumulation, Brain Atrophy, And Cognitive Decline In Emergent Alzheimer's Disease, Ying Xia, Pierrick Bourgeat, Vincent Doré, Jurgen Fripp, Yen Ying Lim, Simon M. Laws, Christopher Fowler, Christopher C. Rowe, Colin L. Masters, Elizabeth J. Coulson, Paul Maruff
Research outputs 2022 to 2026
Introduction : Emergent Alzheimer's disease (AD) represents a transitional stage where cognitively unimpaired (CU) individuals exhibit subthreshold but increasing amyloid-β (Aβ) levels. The impact of Aβ accumulation on brain volume loss and cognition during this early stage remains unclear. Methods: This retrospective cohort study analyzed data from 408 CU participants who were initially Aβ− (< 15 Centiloids) and followed for up to 15 years. Changes in basal forebrain and hippocampal volume, along with domain-specific cognitive performance, were compared between those who progressed to Aβ+ (≥20 Centiloids) and those who remained Aβ−. Results: Sixty-five CU participants progressed to Aβ+, indicating emergent AD, and showed faster Aβ accumulation and subtle memory decline. However, no significant differences in rate of BF and hippocampal atrophy were observed between groups. Discussion: The results suggest that during this emergent phase of AD, Aβ accumulation is associated with episodic memory loss, in the absence of detectable accelerated brain atrophy. Highlights: Identified cognitively unimpaired individuals in the emergent stage of Alzheimer's disease (AD). Emergent AD exhibits a greater rate of amyloid-β (Aβ) accumulation. No accelerated volume loss detected in the basal forebrain or hippocampus. Emergent AD is also associated with a subtle decline in memory. Early Aβ accumulation may impair cognitive function before structural atrophy.
The Rising Returns To R&D: Ideas Are Not Getting Harder To Find, Yoshiki Ando, James Bessen, Xiupeng Wang
The Rising Returns To R&D: Ideas Are Not Getting Harder To Find, Yoshiki Ando, James Bessen, Xiupeng Wang
Research Collection School Of Economics
R&D has grown robustly, yet aggregate productivity growth has stagnated. Is this because “ideas are getting harder to find”? Using microdata from the US Census Bureau this paper estimates R&D effectiveness in the manufacturing sector from 1976 to 2018. We find that the marginal effect of R&D on output and the gross marginal returns to R&D have risen sharply. But rivals’ R&D has also gotten more effective, raising expected obsolescence. But firm productivity growth rises with growth in the R&D stock. Higher obsolescence slows the accumulation of R&D capital, reducing the contribution to productivity growth and shortening innovation lives.
Unraveling Nonperturbative Qcd With Transverse Momentum Hadronic Structures, Tommaso Rainaldi
Unraveling Nonperturbative Qcd With Transverse Momentum Hadronic Structures, Tommaso Rainaldi
Physics Theses & Dissertations
The main purpose of this thesis is to investigate the theoretical foundations of the factorization theorems that involve transverse quark and gluon momentum distributions, and to better understand the interface between foundational questions and phenomenological applications. Many of these applications involve using transverse parton momentum dependent (TMD) correlation functions as tools for probing the complex nonperturbative structures of the hadrons.
We first introduce the concepts of collinear and TMD factorization in a toy-model theory and, by leveraging the comparative simplicity of such a model, we test the range of validity and limitations of the factorization approach. At the same time, …
Evaluating Chatgpt To Answer Multi-Modal Exercises In Computer Science Education, Eng Lieh Ouh, Kar Way Tan, Siaw Ling Lo, Benjamin Gan
Evaluating Chatgpt To Answer Multi-Modal Exercises In Computer Science Education, Eng Lieh Ouh, Kar Way Tan, Siaw Ling Lo, Benjamin Gan
Research Collection School Of Computing and Information Systems
This study investigates ChatGPT-4o's ability to answer multi-modal assessment exercises in computer science (CS) courses. While the use of large language models (LLMs) to answer text-based exercises are extensively researched, their ability to answer exercises involving artifacts of other modalities remains underexplored. To close this gap, we evaluate ChatGPT-4o's answers to 120 multi-modal CS exercises in programming, software design, human-computer interaction, statistical analysis, process analysis, and simulation. The multi-modal artifacts in these exercises include class diagrams, sequence diagrams, user interface images, analytical charts, workflow diagrams and object-flow diagrams. Our comparisons to the expected answers of these exercises show that ChatGPT-4o …
An On-The-Fly Synthesis Framework For Ltl Over Finite Traces, Shengping Xiao, Yongkang Li, Shufang Zhu, Jun Sun, Jianwen Li, Geguang Pu, Moshe Vardi
An On-The-Fly Synthesis Framework For Ltl Over Finite Traces, Shengping Xiao, Yongkang Li, Shufang Zhu, Jun Sun, Jianwen Li, Geguang Pu, Moshe Vardi
Research Collection School Of Computing and Information Systems
We present an on-the-fly synthesis framework for Linear Temporal Logic over finite traces (LTLf) based on top-down deterministic automata construction. Existing approaches rely on constructing a complete Deterministic Finite Automaton (DFA) corresponding to the LTLf specification, a process with doubly exponential complexity relative to formula size in the worst case. In this case, the synthesis cannot be conducted until the entire DFA is constructed. This inefficiency is the main bottleneck of existing approaches. To address this challenge, we first present a method for converting LTLf into Transition-based DFA (TDFA) by directly leveraging LTLf semantics, incorporating intermediate results as direct components …
The Aggregate Welfare And Trade Implications Of Contracting Frictions In Global Sourcing, Davin Chor, Lin Ma
The Aggregate Welfare And Trade Implications Of Contracting Frictions In Global Sourcing, Davin Chor, Lin Ma
Research Collection School Of Economics
How much do contracting frictions between global firms and their suppliers impact country welfare and trade? We answer this by developing a model of global sourcing under partial contractibility, where firm-supplier relationships are exposed to a bilateral holdup problem. Sourcing decisions aggregate into a gravity equation for trade flows by organizational mode (intrafirm vs. arm’s length), which we take to structural estimation. We can then evaluate welfare changes with an extended Arkolakis, Costinot and Rodriguez-Clare (2012) formula that incorporates these contracting frictions. Our counterfactual analysis reveals a sizeable average country welfare gain of 9.2% from eliminating contracting frictions in global …
Renal G Protein-Coupled Estrogen Receptor 1 Regulates The Epithelial Sodium Channel Promoting Natriuresis To A Greater Extent In Females, Victoria L Nasci, Jean C Bopassa, Elena Mironova, Megan Rhoads, Ravneet Singh, Dennis P Buehler, David M Pollock, Oleh M Pochynyuk, James D Stockand, Eman Y Gohar
Renal G Protein-Coupled Estrogen Receptor 1 Regulates The Epithelial Sodium Channel Promoting Natriuresis To A Greater Extent In Females, Victoria L Nasci, Jean C Bopassa, Elena Mironova, Megan Rhoads, Ravneet Singh, Dennis P Buehler, David M Pollock, Oleh M Pochynyuk, James D Stockand, Eman Y Gohar
Faculty, Staff and Student Publications
Hypertension prevalence is lower in women than men. Enhanced renal sodium (Na+) handling in females has been implicated in sex-differences in hypertension. Epithelial Na+ channel (ENaC) is a key contributor to Na+ homeostasis and is regulated by estrogen. Recent evidence suggests G protein-coupled estrogen receptor 1 (GPER1) evokes a female-specific natriuresis that involves endothelin-1 (ET-1). ET-1 has been shown to downregulate ENaC activity, but whether GPER1 regulates ENaC to modulate natriuresis is unknown. We tested the hypothesis that renal GPER1 functionally interacts with ENaC to promote natriuresis in a sex-specific manner. RNAscope confirmed co-expression of GPER1 and ENaC in rat …
Semi-Automated Hippocampal Avoidance Whole-Brain Radiotherapy Planning, Dong Joo Rhee, Subha Perni, Kelly J Perrin, Kevin E Casey, Alexandra O Leone, Callistus M Nguyen, Laurence E Court, He Wang, Xin Wang, Eun Young Han
Semi-Automated Hippocampal Avoidance Whole-Brain Radiotherapy Planning, Dong Joo Rhee, Subha Perni, Kelly J Perrin, Kevin E Casey, Alexandra O Leone, Callistus M Nguyen, Laurence E Court, He Wang, Xin Wang, Eun Young Han
Faculty, Staff and Student Publications
Background: Hippocampal avoidance whole-brain radiotherapy (HA-WBRT) is designed to spare cognitive function by reducing radiation dose to the hippocampus during the treatment of brain metastases. Current manual planning methods can be time-consuming and may vary in quality, necessitating the development of automated approaches to streamline the process and ensure consistency.
Purpose: To automate hippocampal avoidance whole-brain radiotherapy (HA-WBRT) planning.
Methods: Our algorithm automatically contours organs-at-risk (OARs) and the hippocampal-avoidance brain target. The algorithm generates planning structures from given contours, utilizing preset beam parameters and dose constraints for optimization. If the dose constraints are unmet, "hotspot" contours will be created to …
1d Thermoembolization Model Using Ct Imaging Data For Porcine Liver, Rohan Amare, Danielle Stolley, Steve Parrish, Megan Jacobsen, Rick R Layman, Chimamanda Santos, Beatrice Riviere, Natalie Fowlkes, David Fuentes, Erik Cressman
1d Thermoembolization Model Using Ct Imaging Data For Porcine Liver, Rohan Amare, Danielle Stolley, Steve Parrish, Megan Jacobsen, Rick R Layman, Chimamanda Santos, Beatrice Riviere, Natalie Fowlkes, David Fuentes, Erik Cressman
Faculty, Staff and Student Publications
Innovative therapies such as thermoembolization are expected to play an important role in improving care for patients with diseases such as hepatocellular carcinoma. Thermoembolization is a minimally invasive strategy that combines thermal ablation and embolization in a single procedure. This approach exploits an exothermic chemical reaction that occurs when an acid chloride is delivered via an endovascular route. However, comprehension of the complexities of the biophysics of thermoembolization is challenging. Mathematical models can aid in understanding such complex processes and assisting clinicians in making informed decisions. In this study, we used a Hagen-Poiseuille 1D blood flow model to predict the …
Spontaneous Tumor Regression And Immunotherapy Response Demonstrate Clonal T-Cell Expansion In Merkel Cell Carcinoma, Patrick Hallaert, John W Roman, Mairead Baker, Natasha T Hill, Jennifer L Marte, James L Gulley, Nicholas Logemann, Courtney W Hudgens, Alexandre Reuben, Isaac Brownell
Spontaneous Tumor Regression And Immunotherapy Response Demonstrate Clonal T-Cell Expansion In Merkel Cell Carcinoma, Patrick Hallaert, John W Roman, Mairead Baker, Natasha T Hill, Jennifer L Marte, James L Gulley, Nicholas Logemann, Courtney W Hudgens, Alexandre Reuben, Isaac Brownell
Faculty, Staff and Student Publications
Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine skin cancer that is responsive to immune checkpoint inhibitors (ICI). On rare occasion, MCC spontaneously regresses. It is speculated that this regression occurs when biopsy-induced antigen shedding precipitates an immune response. Here, we demonstrate the activation of an adaptive immune response in a patient whose tumor underwent spontaneous regression after biopsy. To evaluate the tumor immune microenvironment during regression, we performed quantitative immunohistochemical analysis and T-cell receptor (TCR) sequencing. Relative to baseline, the regressing tumor showed evidence of an activated cytotoxic T-cell response together with increased TCR clonality, greater representation …
Impacts Of Radiation On Metabolism And Vascular Cell Senescence, Junichi Abe, Khanh Chau, Anahita Mojiri, Guangyu Wang, Masayoshi Oikawa, Venkata S K Samanthapudi, Abigail M Osborn, Keila C Ostos-Mendoza, Karla N Mariscal-Reyes, Tammay Mathur, Abhishek Jain, Joerg Herrmann, Syed Wamique Yusuf, Sunil Krishnan, Anita Deswal, Steven H Lin, Sivareddy Kotla, John P Cooke, Nhat-Tu Le
Impacts Of Radiation On Metabolism And Vascular Cell Senescence, Junichi Abe, Khanh Chau, Anahita Mojiri, Guangyu Wang, Masayoshi Oikawa, Venkata S K Samanthapudi, Abigail M Osborn, Keila C Ostos-Mendoza, Karla N Mariscal-Reyes, Tammay Mathur, Abhishek Jain, Joerg Herrmann, Syed Wamique Yusuf, Sunil Krishnan, Anita Deswal, Steven H Lin, Sivareddy Kotla, John P Cooke, Nhat-Tu Le
Faculty, Staff and Student Publications
Significance: This review investigates how radiation therapy (RT) increases the risk of delayed cardiovascular disease (CVD) in cancer survivors. Understanding the mechanisms underlying radiation-induced CVD is essential for developing targeted therapies to mitigate these effects and improve long-term outcomes for patients with cancer.
Recent Advances: Recent studies have primarily focused on metabolic alterations induced by irradiation in various cancer cell types. However, there remains a significant knowledge gap regarding the role of chronic metabolic alterations in normal cells, particularly vascular cells, in the progression of CVD after RT.
Critical Issues: This review centers on RT-induced metabolic alterations in vascular cells …
Liger-Hn Phase Iii Trials Of Petosemtamab + Pembrolizumab And Petosemtamab Monotherapy In Recurrent Or Metastatic Hnscc, Jean-Pascal Machiels, Jérôme Fayette, Robert Haddad, Douglas Adkins, Maura Gillison, Kevin J Harrington, Sung-Bae Kim, Christophe Le Tourneau, Amanda Psyrri, Ari Rosenberg, Lillian L Siu, Makoto Tahara, William N William, Jim Ford, Shekeab Jauhari, Rebecca Pyle, Yu-Ming Shen, David Yao, Fabian Zohren, Everett Vokes
Liger-Hn Phase Iii Trials Of Petosemtamab + Pembrolizumab And Petosemtamab Monotherapy In Recurrent Or Metastatic Hnscc, Jean-Pascal Machiels, Jérôme Fayette, Robert Haddad, Douglas Adkins, Maura Gillison, Kevin J Harrington, Sung-Bae Kim, Christophe Le Tourneau, Amanda Psyrri, Ari Rosenberg, Lillian L Siu, Makoto Tahara, William N William, Jim Ford, Shekeab Jauhari, Rebecca Pyle, Yu-Ming Shen, David Yao, Fabian Zohren, Everett Vokes
Faculty, Staff and Student Publications
Patients with recurrent/metastatic (r/m) head and neck squamous cell carcinoma (HNSCC) have limited treatment options and a dismal prognosis, especially when their cancer is resistant to standard treatments like anti-programmed cell death protein 1 and platinum-based therapies. Petosemtamab - a human, common light chain, bispecific antibody with enhanced antibody-dependent cellular cytotoxicity targeting epidermal growth factor receptor (EGFR) and leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5) - demonstrated antitumor activity in r/m HNSCC. In many tumor types, including HNSCC, EGFR is an oncogenic driver, while LGR5 is upregulated. LGR5 can potentiate the wingless-type integration site (WNT)/β-catenin signaling pathway in response to …
Developing Reference Plans For Evaluating Global Clinical Trials Credentialing And Psqa Systems, Fre'etta M D Brooks, Mohammad Hussein, Jessica Lye, Christopher L Nelson, Nakamura Mitsuhiro, Mallory C Glenn, Patricia Diez, Rushil Patel, Maddison Shaw, Ileana Silvestre Patallo, Miriam Barry, Catharine H Clark, Joerg Lehmann, Stephen F Kry
Developing Reference Plans For Evaluating Global Clinical Trials Credentialing And Psqa Systems, Fre'etta M D Brooks, Mohammad Hussein, Jessica Lye, Christopher L Nelson, Nakamura Mitsuhiro, Mallory C Glenn, Patricia Diez, Rushil Patel, Maddison Shaw, Ileana Silvestre Patallo, Miriam Barry, Catharine H Clark, Joerg Lehmann, Stephen F Kry
Faculty, Staff and Student Publications
Purpose: To develop a practical framework for creating a diverse set of validated reference plans (varying in complexity) and implement a workflow to introduce beam modeling, calibration, and delivery errors into the reference cohort to test and compare various dosimetry audit methodologies.
Methods: Sixteen IMRT and VMAT reference plans were created, using RayStation software, for four phantom geometries based on established credentialing cases from participating Global Harmonization Group (GHG) members. These reference plans were first validated in a multi-ion-chamber phantom. Nine dosimetric errors (perturbations) were introduced into the plans by modifying beam model and/or delivery parameters (MLC-offset, MLC-transmission, leaf-tip-width, PDD, …
The Landscape Of Malignant Transition: Unraveling Cancer Cell-Of-Origin And Heterogeneous Tissue Microenvironment, Ruihan Luo, Jiajia Liu, Tiangang Wang, Weiling Zhao, Yanfei Wang, Jianguo Wen, Hongyu Wang, Shanli Ding, Xiaobo Zhou
The Landscape Of Malignant Transition: Unraveling Cancer Cell-Of-Origin And Heterogeneous Tissue Microenvironment, Ruihan Luo, Jiajia Liu, Tiangang Wang, Weiling Zhao, Yanfei Wang, Jianguo Wen, Hongyu Wang, Shanli Ding, Xiaobo Zhou
Faculty, Staff and Student Publications
Understanding disease progression and sophisticated tumor ecosystems is imperative for investigating tumorigenesis mechanisms and developing novel prevention strategies. Here, we dissected heterogeneous microenvironments during malignant transitions by leveraging data from 1396 samples spanning 13 major tissues. Within transitional stem-like subpopulations highly enriched in precancers and cancers, we identified 30 recurring cellular states strongly linked to malignancy, including hypoxia and epithelial senescence, revealing a high degree of plasticity in epithelial stem cells. By characterizing dynamics in stem-cell crosstalk with the microenvironment along the pseudotime axis, we found differential roles of ANXA1 at different stages of tumor development. In precancerous stages, reduced …
Understanding Rural Schools’ Capacity To Learn About Evidence-Based Practices That Promote Youth Mental Health: A Comparative Case Study, Savannah Hobbs, Elaine S. Belansky, Nick Cutforth, Cynthia Hazel
Understanding Rural Schools’ Capacity To Learn About Evidence-Based Practices That Promote Youth Mental Health: A Comparative Case Study, Savannah Hobbs, Elaine S. Belansky, Nick Cutforth, Cynthia Hazel
The Rural Educator
Amid growing student mental health concerns, numerous evidence-based practices (EBPs) exist to promote student mental health, but most rural schools do not have these practices in place. Little is known about the organizational capacity of rural schools to learn about and select youth mental health EBPs, or the role research intermediaries can play to support these processes. In this study, 11 middle school staff from three rural school districts participated in surveys and semi-structured interviews to provide information on how schools learn about and select mental health EBPs, related barriers and facilitators, and the role of intermediary support. A semi-structured …
Place-Sustaining Partnerships For Rural Education And Workforce Development, Guan K. Saw, Ryan Culbertson
Place-Sustaining Partnerships For Rural Education And Workforce Development, Guan K. Saw, Ryan Culbertson
The Rural Educator
This policy brief draws on the 2024 National Academies of Sciences, Engineering, and Medicine (NASEM) report on K–12 STEM Education and Workforce Development in Rural Areas to examine how place-sustaining partnerships—among schools, communities, higher education, and industry—advance rural education and workforce development. Through examples of state-led initiatives and community-driven models, the brief illustrates how cross-sector collaboration rooted in local context can develop college and career pathways that equip rural learners to thrive and sustain the long-term vitality of rural communities.
Building Respect, Responsibility, And Reciprocity: Insights From A Rural Stem Research Practice Design Partnership, Amanda Obery, Martha Cabell, Shelly Hogan, Matt Queen
Building Respect, Responsibility, And Reciprocity: Insights From A Rural Stem Research Practice Design Partnership, Amanda Obery, Martha Cabell, Shelly Hogan, Matt Queen
The Rural Educator
Rural schools often have strong community involvement and thus can offer educational experiences to students that are more closely aligned with local people and places. However, curricula in rural schools rarely offer this same alignment. Partnerships with others, including higher education, can support rural schools in creating STEM curricula that center the resources and careers present in their communities. A research design practice partnership (RPDP) was created as a Third Space to enable the development of locally relevant STEM curricula. The partnership was formed focusing on respect, responsibility, and reciprocity, necessary tenets as the roles and goals of the project …
Tefl In Rural Schools Of Uruguay: Designing A Network Of Practice To Enhance Language Teaching, Vanessa Z. Mari, Valentina Alpuín
Tefl In Rural Schools Of Uruguay: Designing A Network Of Practice To Enhance Language Teaching, Vanessa Z. Mari, Valentina Alpuín
The Rural Educator
This article explores the program “Inglés Sin Límites” (English Without Limits), established in Uruguay to bridge teaching English as a foreign language (TEFL) instruction between urban and rural schools. As part of these efforts, the Godparents Project was created to develop a network of practices in which educators in rural schools could be supported in the teaching of English. Through the lens of a network of practice, we discuss the approaches used to support teachers as well as recommendations for expanding these practices and supporting rural teachers and students.
Navigating Through Difficult Roads And Terrains: Novice Teachers’ Challenges In Teaching In Remote Mountainous Settings In The Philippines, Albert C. Albina, Sarah Jean A. Salmorin, Dannyla N. Cainos, Rhea Mae C. Montano
Navigating Through Difficult Roads And Terrains: Novice Teachers’ Challenges In Teaching In Remote Mountainous Settings In The Philippines, Albert C. Albina, Sarah Jean A. Salmorin, Dannyla N. Cainos, Rhea Mae C. Montano
The Rural Educator
In rural areas, the adaptation of urban-originating elementary teachers to remote mountainous school locations poses substantial challenges and necessitates innovative strategies. This study primarily explored the lived experiences of newly hired elementary teachers residing in urban areas but assigned to remote mountainous locations, specifically focusing on their adaptation processes, the challenges they encountered, and support mechanisms that influenced their teaching roles. Using a descriptive phenomenological approach and reflexive thematic analysis, this study involved in-depth interviews with nine newly hired urban-originating elementary teachers who were assigned to teach in rural schools in the Municipality of Santa Catalina, Basay, and Bayawan City, …
Understanding Grade 10 Learners’ Mathematics Learning Experiences In Rural Schools: Applying The Self-Determination Theory, Hlamulo Wiseman Mbhiza, Thabisile Nkambule
Understanding Grade 10 Learners’ Mathematics Learning Experiences In Rural Schools: Applying The Self-Determination Theory, Hlamulo Wiseman Mbhiza, Thabisile Nkambule
The Rural Educator
The increasing performative expectation in mathematics continuously positions rural learners in a deficit manner within the education system in post-apartheid South Africa. The often-cited low academic performance of rural learners in mathematics fosters the belief that something is wrong with their mathematical learning abilities. The problem with narrow and often decontextualized perspectives of rural learners is that their interactions with mathematical content are frequently overlooked in education research. The purpose of this study was to critically explore grade 10 rural learners’ mathematics learning experiences. We employed a qualitative descriptive approach within a case study design, using semi-structured individual interviews supported …