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Homework, Households, And Hurdles: The Unexpected Drivers Of Student Graduation Perceptions, Daniel Alhassan, Zahra Fatah, Priscilla Mansah Codjoe, Caroline Bena Kuno, Dorcas Ofori-Boateng Jun 2025

Homework, Households, And Hurdles: The Unexpected Drivers Of Student Graduation Perceptions, Daniel Alhassan, Zahra Fatah, Priscilla Mansah Codjoe, Caroline Bena Kuno, Dorcas Ofori-Boateng

Mathematics and Statistics Faculty Publications and Presentations

Students’ perceptions of their likelihood to graduate are important determinants of their academic engagement, yet these perceptions remain understudied. This study, which is based on the 2021 Monitoring the Future survey of 8th- and 10th-grade students in the United States, uses machine learning algorithms to identify the most important factors that influence these perceptions. Among the tested models, random forest provided the best classification performance. Using permutation-based feature importance, we identified frequent participation in schoolwork, maternal education, paternal education, and homework completion as the most important predictors of students’ graduation perceptions. These results highlight the importance of targeted and well-coordinated …


Descriptive Sensory Analysis Of Gluten-Containing And Gluten-Free Chocolate Chip Cookies Available In The Marketplace, Eniola Ola, Victoria J. Hogan, Han-Seok Seo Jun 2025

Descriptive Sensory Analysis Of Gluten-Containing And Gluten-Free Chocolate Chip Cookies Available In The Marketplace, Eniola Ola, Victoria J. Hogan, Han-Seok Seo

Food Science Faculty Publications and Presentations

Limited research has systematically compared the detailed sensory profiles of commercially available gluten-containing (C) and gluten-free (F) cookies using trained panelists. This study aimed to develop a comprehensive sensory lexicon for C and F chocolate chip cookies and identify key sensory attributes that differentiate them. Seven professionally trained panelists created a lexicon of 33 attributes spanning aroma, flavor, basic taste, texture, and residual property. Using this lexicon, a descriptive analysis was conducted on 12 C and 12 F cookie samples. Multivariate analysis of variance revealed significant differences between the two groups across the 33 sensory attributes (p < 0.05). A mixed model analysis showed that C cookies had higher intensities of chocolate-related and sweet aroma complex notes, while F cookies exhibited stronger nutty, artificial, and off-note flavors. In terms of texture, F cookies were higher in toothpack and powdery mouthcoat, while C cookies displayed more melt-in-mouth characteristics. Principal component analysis and agglomerative hierarchical clustering revealed three distinct clusters of test samples within both crispy and chewy cookie types, with some F cookies closely aligning with C profiles. These findings, along with the developed lexicon, provide a valuable foundation for enhancing the sensory appeal and quality of gluten-free chocolate chip cookies.


A Rubric For Assessing Conformance To The Ten Rules For Credible Practice Of Modeling And Simulation In Healthcare, Alexandra Manchel, Ahmet Erdemir, Lealem Mulugeta, Joy Ku, Bruno Rego, Marc Horner, William Lytton, Jerry Myers, Rajanikanth Vadigepalli Jun 2025

A Rubric For Assessing Conformance To The Ten Rules For Credible Practice Of Modeling And Simulation In Healthcare, Alexandra Manchel, Ahmet Erdemir, Lealem Mulugeta, Joy Ku, Bruno Rego, Marc Horner, William Lytton, Jerry Myers, Rajanikanth Vadigepalli

Computational Medicine Center Faculty Papers

The power of computational modeling and simulation (M&S) is realized when the results are credible, and the workflow generates evidence that supports credibility for the context of use. The Committee on Credible Practice of Modeling & Simulation in Healthcare was established to help address the need for processes and procedures to support the credible use of M&S in healthcare and biomedical research. Our community efforts have led to the Ten Rules (TR) for Credible Practice of M&S in life sciences and healthcare. This framework is an outcome of a multidisciplinary investigation from a wide range of stakeholders beginning in 2012. …


Fostering Inclusive Teaching: Care-Centred Approaches In Business Schools Of The Visegrad Countries, Agnieszka Brzozowska Jun 2025

Fostering Inclusive Teaching: Care-Centred Approaches In Business Schools Of The Visegrad Countries, Agnieszka Brzozowska

Studia i Materiały Wydział Zarządzania Uniwersytet Warszawski

Purpose: This study aims to explore the experiences of business students in the Visegrad Group countries during the transition to online learning prompted by the COVID-19 pandemic, with a focus on the social aspects of their educational experiences.

Design/methodology/approach: Utilizing qualitative research methods, semi-structured interviews were conducted with 40 students across four business schools in the Czech Republic, Hungary, Poland, and Slovakia. The interviews were analysed thematically to identify key insights regarding students' perceptions of online education and the importance of social interactions.

Findings: The findings reveal that students significantly missed interpersonal relationships during online learning, highlighting a strong …


Quantum Management: A Revolution In The Future Of Management Science And Business Practice, Bartosz Niedzielski Jun 2025

Quantum Management: A Revolution In The Future Of Management Science And Business Practice, Bartosz Niedzielski

Studia i Materiały Wydział Zarządzania Uniwersytet Warszawski

Purpose: The article aims to propose a nominal definition of quantum management and analyze the differences between the classical and quantum paradigms of management, with particular emphasis on their impact on organizational structure and decision-making processes.

Methodology: The article is based on a synthetic literature review concerning the application of quantum theory in management sciences, including publications from bibliometric databases such as Scopus, Web of Science, and Elsevier. The review focuses on the theoretical and practical differences between the classical and quantum approaches to management. Additionally, a comparative method is used to identify key differences between these two …


The Impact Of Loper Bright V. Raimondo: An Empirical Review Of The First Six Months, Robin Kundis Craig Jun 2025

The Impact Of Loper Bright V. Raimondo: An Empirical Review Of The First Six Months, Robin Kundis Craig

Minnesota Law Review Vols. 106:2 onward (2021-present)

One of the most impactful decisions of the U.S. Supreme Court’s 2023–2024 term was Loper Bright Enterprises v. Raimondo, which overruled the forty-year-old administrative law doctrine of Chevron deference. This doctrine allowed federal agencies to interpret ambiguities in the statutes that they administer. Courts cited Chevron over 18,000 times in its forty-year existence, or roughly 450 times a year—more than once a day, on average. Small wonder, then, that in the first six months after the Supreme Court decided Loper Bright, courts cited it more than 400 times. This article provides an empirical review of what courts are doing with …


Water Flowing Down Wall Street, Vanessa Casado Pérez Jun 2025

Water Flowing Down Wall Street, Vanessa Casado Pérez

Minnesota Law Review Vols. 106:2 onward (2021-present)

Water scarcity is a perennial problem with dire consequences for the United States and governments around the world. A lack of adequate water resources is a systematic cause of environmental harm, economic damage, and societal division. Climate change has exacerbated these problems making water even more valuable and essential. Financial actors have turned water into the new oil. These large financial actors profiteer from buying and selling water without any interest in its actual use as an input of production. Instead, they typically seek to hold these rights until dire situations, like droughts and fires, cause temporary, but large, spikes …


Memory Matters: The Journals Of Cecilia Maria O’Conway And Rosetta Landry White, Betty Ann Mcneil Jun 2025

Memory Matters: The Journals Of Cecilia Maria O’Conway And Rosetta Landry White, Betty Ann Mcneil

Vincentian Studies

Betty Ann McNeil describes the journals of two of the very first Sisters of Charity, Cecilia Maria O’Conway and Rosetta (Rose) Landry White, who knew Saint Elizabeth Ann Seton and her family. Cecilia was the first to join Elizabeth in Baltimore as a Sister of Charity in early December 1808 at age twenty-one. McNeil tells us, “Cecilia taught at St. Joseph’s School until missioned to Philadelphia (1814) and New York (1817)” before withdrawing from the Sisters of Charity in 1823. At age twenty-five, Rose joined Elizabeth in late June 1809 and served as mother of the Sisters of Charity after …


John Timon, The Vincentian: Filling Out The Biography Of The Founding Bishop Of Buffalo, John E. Rybolt Jun 2025

John Timon, The Vincentian: Filling Out The Biography Of The Founding Bishop Of Buffalo, John E. Rybolt

Vincentian Studies

John Rybolt traces the biographical information we have about John Timon and talks about the bishop's career and his lifelong devotion to the Vincentians, even when he was painfully separated from the Congregation because he was forced to join the episcopacy against his will. At the time, the Congregation's Rules stated that Vincentians could not stay within the community if they accepted church office, especially not without receiving the approval of the superior general. But Timon's appointment could hardly have been refused, since it came directly from the pope.


About Vh Jun 2025

About Vh

Vincentian Studies

No abstract provided.


Cover And Contents Jun 2025

Cover And Contents

Turkish Journal of Agriculture and Forestry

No abstract provided.


Microstructural And Interfacial Analysis Of Yb2si2o7 Based Coatings Under Varied Steam Conditions, Daniel Scotson, Daniel Scotson, Esma Yilmaz, Ping Xiao Jun 2025

Microstructural And Interfacial Analysis Of Yb2si2o7 Based Coatings Under Varied Steam Conditions, Daniel Scotson, Daniel Scotson, Esma Yilmaz, Ping Xiao

Thermal and Environmental Barrier Coatings VII

Please click Additional Files below to see the full abstract


Interview With Robert Cliver, Jacey Terrill Jun 2025

Interview With Robert Cliver, Jacey Terrill

What Happened Here

This is a transcript of an oral history interview with Robert Cliver, a professor of History at Cal Poly Humboldt for eighteen years. He is highly critical of the administration’s choices during the protest and greatly supports the protesters, not only in their right to protest but in their messaging. He explains his negative views on the Israeli government, while also emphasizing that the protesters did not act from antisemitic sentiments. Much of his interview comes from the perspective of a historian, and knowing this document may be used by historians in the future, he extensively explains his reasoning. He …


Effectiveness Of Seca Skin Public Relations Marketing Through Live Streaming On Tiktok, Mochamad Alvansa, Margareta Manalu Jun 2025

Effectiveness Of Seca Skin Public Relations Marketing Through Live Streaming On Tiktok, Mochamad Alvansa, Margareta Manalu

Journal of Indonesian Tourism and Policy Studies

This study examines the utilization of TikTok's live streaming feature as a public relations marketing strategy in the beauty industry. Using a qualitative descriptive method, the research is grounded in public relations marketing and live streaming theories. Through in-depth interviews, it explores how the beauty brand Seca Skin optimizes this feature to expand market reach, increase sales, and enhance consumer engagement. The findings reveal that Seca Skin successfully meets four key aspects of live-stream selling: Attractiveness, Trustworthiness, Expertise, and Purchase Convenience. These factors contribute to higher audience engagement, strengthened customer loyalty, and more effective purchasing decisions. Moreover, the study highlights …


Our Lady Of Peace: John Joseph Lynch’S Pilgrimage To Niagara Falls, Amelia Gallagher Jun 2025

Our Lady Of Peace: John Joseph Lynch’S Pilgrimage To Niagara Falls, Amelia Gallagher

Vincentian Studies

This article relates how John Joseph Lynch established Niagara Falls as a pilgrimage site, which he envisioned as being the first such site in the United States. In the nineteenth century, Niagara was viewed as such a spectacular natural wonder that it frequently inspired religious devotion, a history that Lynch encouraged and continued. The evolution of nineteenth- and twentieth-century views of Niagara and of pilgrimage in general are discussed. Niagara's role in American history is also explored.


Saint Elizabeth Ann Seton As A Mystic, Sung-Hae Kim Jun 2025

Saint Elizabeth Ann Seton As A Mystic, Sung-Hae Kim

Vincentian Studies

Sung-Hae Kim describes how three key spiritual experiences in Elizabeth Seton’s life confirm her identity as a mystic according to William James’s four characteristics of the mystic state. These traits are ineffability, noetic quality, transiency, and passivity, and such experiences must lead to union with God. Elizabeth wrote about these experiences, which occurred when she was fourteen in New Rochelle, New York; twenty-nine in the lazaretto of Livorno, Italy; and sometime near her death at the age of forty-six in Emmitsburg. As Kim says, these “purify[ied] her ability to love, leading to serene peace and union with God and his …


The Body In Extremist White Supremacism, Mehr Latif, Kathleen Blee, Matthew Demichele, Pete Simi Jun 2025

The Body In Extremist White Supremacism, Mehr Latif, Kathleen Blee, Matthew Demichele, Pete Simi

Sociology Faculty Articles and Research

This article advances the study of racial extremism by analyzing how its practices of violence and sexuality are marked on the bodies of participants in the form of scars, physical stances, abuse, tattoos, pregnancy, injury, strength and size, using an extraordinarily rich and extensive set of narratives collected from lengthy in-person interviews with 47 former members of U.S. extremist white supremacist groups. It asks how embodied practices of violence and sexuality enable extremist white supremacist groups and actors, how embodied practices of violence and sexuality disable these groups and actors, and how gender matters in embodied practices in these groups. …


Probation Officers’ Perspectives Of Outside Services In Reducing Recidivism, Karla Murguia Jun 2025

Probation Officers’ Perspectives Of Outside Services In Reducing Recidivism, Karla Murguia

Walden Dissertations and Doctoral Studies

Research has underscored the critical role of probation officers in improving rates of recidivism. However, the literature on the comprehensive impact of outside services on recidivism was sparse and underdeveloped. The purpose of this qualitative study was to explore how probation officers in court services and a community corrections agency in Garden City, Kansas perceived the utility of outside services in reducing adult recidivism for probationers. Ecological systems theory was used to guide the study. Eight probation officers recruited via purposive sampling participated in semistructured interviews. Transcribed data were analyzed using a six-step thematic analysis protocol. Findings revealed that probationers …


Core State Injury Prevention Program Listening Sessions Report June 2025 Report, Camille Velarde, Yvonnie Baik, Elena Martinez, Theresa Cruz Jun 2025

Core State Injury Prevention Program Listening Sessions Report June 2025 Report, Camille Velarde, Yvonnie Baik, Elena Martinez, Theresa Cruz

Reports & Documents

Background: Injury and violence remain pressing public health challenges in New Mexico, particularly in rural and underserved communities. To inform prevention strategies, the University of New Mexico Prevention Research Center partnered with the New Mexico Department of Health and local organizations to conduct community listening sessions focused on upstream approaches addressing shared risk and protective factors.

Methods: Four listening sessions were conducted in 2025 with stakeholders from county health councils and community organizations. Using a rapid qualitative analysis approach, researchers analyzed participant perspectives on local injury and violence concerns, familiarity with upstream frameworks, and communication preferences.

Results: Participants identified overlapping …


From Assembly Lines To The Open Road: Predicting Rare Events In Autonomous Systems, Ruwan Wickramarachchi Jun 2025

From Assembly Lines To The Open Road: Predicting Rare Events In Autonomous Systems, Ruwan Wickramarachchi

Publications

In the age of embodied AI and smart automation, autonomous agents are increasingly deployed in high-stakes, real-world environments. Ensuring the robustness and resilience of these systems in the face of rare but critical failure events is essential for their safe and reliable operation. Accurate forecasting of such rare events is particularly crucial, as a single overlooked anomaly can lead to catastrophic consequences. In manufacturing, for instance, unplanned downtime due to rare failures costs industries over \$50 billion annually, with sectors like automotive losing more than \$2 million per hour—even with preventive maintenance systems in place.

However, the extreme rarity and …


A Review Of Plant–Microbe Interactions In The Rhizosphere And The Role Of Root Exudates In Microbiome Engineering, Anagha Wankhade, Emma Wilkinson, David W. Britt, Amita Kaundal Jun 2025

A Review Of Plant–Microbe Interactions In The Rhizosphere And The Role Of Root Exudates In Microbiome Engineering, Anagha Wankhade, Emma Wilkinson, David W. Britt, Amita Kaundal

Biological Engineering Student Research

Microbial interactions within the rhizosphere are fundamental to plant health, influencing nutrient availability, stress tolerance, and pathogen resistance. Beneficial microbes, such as plant growth-promoting microbes (PGPMs), including bacteria and mycorrhizal fungi, enhance plant resilience through mechanisms like nutrient solubilization, phytohormone production, and pathogen suppression via antimicrobial compounds and siderophores. Root exudates, composed of sugars, organic acids, and secondary metabolites, act as chemoattractants that shape the rhizosphere microbiome by recruiting beneficial microbes. Microbial metabolites can, in turn, modulate plant physiology and exudate profiles, thereby reinforcing mutualistic interactions. Stress conditions alter exudate composition, enabling plants to attract specific microbes that aid in …


A Conditional Point Cloud Diffusion Model For Deformable Liver Motion Tracking Via A Single Arbitrarily-Angled X-Ray Projection, Jiacheng Xie, Hua-Chieh Shao, Yunxiang Li, Shunyu Yan, Chenyang Shen, Jing Wang, You Zhang Jun 2025

A Conditional Point Cloud Diffusion Model For Deformable Liver Motion Tracking Via A Single Arbitrarily-Angled X-Ray Projection, Jiacheng Xie, Hua-Chieh Shao, Yunxiang Li, Shunyu Yan, Chenyang Shen, Jing Wang, You Zhang

Faculty, Staff and Student Publications

Objective. Deformable liver motion tracking using a single x-ray projection enables real-time motion monitoring and treatment intervention. We introduce a conditional point cloud diffusion (PCD) model-based framework for accurate and robust liver motion tracking from arbitrarily angled single x-ray projections. Approach. We propose a conditional PCD model for liver motion tracking (PCD-Liver), which estimates volumetric liver motion by solving deformable vector fields (DVFs) of a prior liver surface point cloud, based on a single x-ray image. It is a patient-specific model of two main components: a rigid alignment model to estimate the liver’s overall shifts, and a conditional PCD …


Pharmaceutical Innovation Through Computational Drug Design: A Comprehensive Exploration, Manasa Chandramouli, Madhusudhan Heggadadevanakote Surendra Jun 2025

Pharmaceutical Innovation Through Computational Drug Design: A Comprehensive Exploration, Manasa Chandramouli, Madhusudhan Heggadadevanakote Surendra

Makara Journal of Science

Chemical biology and computer-aided drug design (CADD) are crucial for identifying and optimizing lead molecules in drug development. Chemical biology is employed to determine the biological function of the target and the mode of action of a chemical modulator. At the same time, in CADD, promising candidate medications are identified based on the structure of the target or known bioactive ligands. Structure-based and ligand-based drug designs should be used in tandem, and their integration with experimental methods can considerably accelerate drug design. Furthermore, the use of CADD along with conventional experimental approaches increases the efficiency and accuracy of the discovery …


Correction: Identification Of A Fusobacterial Rna-Binding Protein Involved In Host Small Rna-Mediated Growth Inhibition, Pu-Ting Dong, Mengdi Yang, Jie Hu, Lujia Cen, Peng Zhou, Difei Xu, Peng Xiong, Jiahe Li, Xuesong He Jun 2025

Correction: Identification Of A Fusobacterial Rna-Binding Protein Involved In Host Small Rna-Mediated Growth Inhibition, Pu-Ting Dong, Mengdi Yang, Jie Hu, Lujia Cen, Peng Zhou, Difei Xu, Peng Xiong, Jiahe Li, Xuesong He

Faculty, Staff and Student Publications

No abstract provided.


Medical Populism And Epistemic Rights, Kurt Christian B. Tubera, Mark Anthony Dacela Jun 2025

Medical Populism And Epistemic Rights, Kurt Christian B. Tubera, Mark Anthony Dacela

Asia-Pacific Social Science Review

Medical populism, a performance-based political style that orchestrates antagonistic relations between the people and medical establishments, has served as a concept for analyzing the politicization of healthcare. With its four fundamental features, that is, invoking knowledge claims contrary to medical experts’ advice, simplifying discourse, dramatizing responses to public health crises, and forging divisions, medical populism compromises our access to accurate medical or public health information. Populist leaders abuse their epistemic authority and betray public trust when they propagate false information, medical or otherwise. And insofar as accurate medical or public health information is an epistemic good that we have the …


Systematic Review: Recent Developments In Magnetic-Nanoparticle-Based Dna Extraction, Stanley Evander Emeltan Tjoa, Mudasir Mudasir, Edi Suharyadi, Budi Setiadi Daryono Jun 2025

Systematic Review: Recent Developments In Magnetic-Nanoparticle-Based Dna Extraction, Stanley Evander Emeltan Tjoa, Mudasir Mudasir, Edi Suharyadi, Budi Setiadi Daryono

Makara Journal of Science

Deoxyribonucleic acid (DNA) is a research object for various molecular fields of study, and DNA extraction is a basic procedure in molecular biology laboratories. DNA extraction methods are evolving, from several steps using organic solvents to recent technology using magnetic nanoparticles as adsorbents for the purification step. The use of magnetic nanoparticles for DNA extraction is magnetizing because it is simple without heavy machinery, such as centrifugation and organic solvents. The application of this method is extensive and diverse. This systematic review summarizes current development trends for some aspects of this DNA extraction system from the magnetic nanoparticle synthesis method, …


Porous Calcium Carbonate-Poly-2-Acrylamido-2-Methylpropanesulfonic Acid Microspheres Embedded With Silver-Based Nanoparticles As Potential Antibacterial Carriers For Bone Infections, Novi Dwi Widya Rini, Adinda Asmoro, Systi Adi Rachmawati, Husaini Ardy, Akfiny Hasdi Aimon, Akihiro Kishimura, Yoshiki Katayama, Arie Wibowo Jun 2025

Porous Calcium Carbonate-Poly-2-Acrylamido-2-Methylpropanesulfonic Acid Microspheres Embedded With Silver-Based Nanoparticles As Potential Antibacterial Carriers For Bone Infections, Novi Dwi Widya Rini, Adinda Asmoro, Systi Adi Rachmawati, Husaini Ardy, Akfiny Hasdi Aimon, Akihiro Kishimura, Yoshiki Katayama, Arie Wibowo

Makara Journal of Science

Implant-associated infections (IAIs) are a significant complication following orthopedic surgeries and are mainly caused by Staphylococcus aureus. In this study, microspheres based on hybrid calcium carbonate–poly-2-acrylamido-2-methylpropane sulfonic acid (CaCO3-PAMPS) embedded with silver-based nanoparticles (AgNPs) were developed as potential antibacterial drug carriers for IAIs. AgNPs were prepared via a green synthesis approach, which employed Indonesian wild honey as a reducing and capping agent. PAMPS concentrations (0.025%, 0.050%, and 0.075% w/v) and silver ion (Ag+) concentrations in solution (0%, 2.5%, and 4% w/v) were varied. Scanning electron microscopy images showed that samples with 0.050% w/v PAMPS and …


Enhanced Crack Resistance Of Porous Anodic Aluminum Oxide Grown On A Tubular Substrate With The Additive Ethylene Glycol, Manogari Sianturi, Ariadne Laksmidevi Juwono, Anawati Anawati Jun 2025

Enhanced Crack Resistance Of Porous Anodic Aluminum Oxide Grown On A Tubular Substrate With The Additive Ethylene Glycol, Manogari Sianturi, Ariadne Laksmidevi Juwono, Anawati Anawati

Makara Journal of Science

The growth of a porous anodic aluminum oxide (PAAO) layer with fewer cracks on a tubular substrate is quite challenging. The PAAO layer on a curved surface grows slower than that on a flat surface and is susceptible to cracking. This study aims to improve the crack resistance of the PAAO layer grown on a tubular aluminum substrate by adding ethylene glycol (EG). Each bath contained additive concentrations of 0, 5, 10, and 15 vol% EG. Anodization proceeded for 4 h at a temperature of 10 ℃ using the potentiostatic mode at 25 V in a sulfuric acid bath and …


Phylogenetic Analysis Of Ftsz In Wolbachia: Implications For Host Specificity, Anwar Rovik, Ayu Rahayu Jun 2025

Phylogenetic Analysis Of Ftsz In Wolbachia: Implications For Host Specificity, Anwar Rovik, Ayu Rahayu

Makara Journal of Science

Wolbachia are the most prevalent and successful endosymbiont in invertebrates and are categorized into 21 supergroups based on genetic phylogeny. The filamenting temperature-sensitive Z (FtsZ) protein is essential for bacterial cell division and is hypothesized to play a role in Wolbachia's control of host reproduction. However, despite FtsZ's importance, little is known about its diversity and function within Wolbachia. This study investigated the variability of the FtsZ-encoding gene among Wolbachia strains and their hosts. FtsZ gene sequences were retrieved from the National Center for Biotechnology Information database, and representative sequences were randomly selected from each host species and analyzed …


Synthesis Of Carboxymethyl Cellulose From Nypa Fruticans For Coating Metformin On Zn-Based Metal-Organic Framework Nanohybrid As A Bionanocomposite Drug Delivery System, Delviani Delviani, Viola Giary Rizkillah Maharani, Putri Nur Shadrina, Tri Warni, Regina Wan Azizah, Indra Lasmana Tarigan, Madyawati Latief Jun 2025

Synthesis Of Carboxymethyl Cellulose From Nypa Fruticans For Coating Metformin On Zn-Based Metal-Organic Framework Nanohybrid As A Bionanocomposite Drug Delivery System, Delviani Delviani, Viola Giary Rizkillah Maharani, Putri Nur Shadrina, Tri Warni, Regina Wan Azizah, Indra Lasmana Tarigan, Madyawati Latief

Makara Journal of Science

Diabetes is a common and rapidly spreading disease that affects 6.6% of the world’s population. Metformin hydrochloride (HCl) is an effective oral pharmacological treatment for type 2 diabetes mellitus (T2DM) patients because of its capability to reduce glucose levels and the risk of hypoglycaemia. However, gastrointestinal sensitivities to this drug can cause diarrhoea, nausea, vomiting and stomach ache. An alternative is controlled release technology by coating metformin with carboxymethyl cellulose (CMC) and zinc-metal-organic framework (Zn-MOF) through the encapsulation method. Therefore, this study aimed to coat metformin formulations using CMC in a Zn-MOF to control release into the body and minimise …