Digital Commons Network^™

The Impact Of Blood-Based Biomarkers And Disease-Modifying Medications On Anticipated Reactions Of Learning Alzheimer Disease Risk Information, Matthew Charles Picchiello

Arts & Sciences Graduate Student Theses and Dissertations

In recent years, the Alzheimer disease (AD) field has seen significant advancements, including the development of blood-based biomarker (BBBM) tests for risk assessment and the approval of new disease-modifying therapies. These innovations are rapidly reshaping the landscape of clinical care. However, public understanding and attitudes toward these developments remain unclear. To address this gap, the present study used a vignette-based, cross-sectional survey grounded in the Health Belief Model (HBM) to examine older adults’ awareness, knowledge, and anticipated reactions to BBBM testing and novel AD treatments. A nationally representative sample of 450 adults (aged 55+) in terms of race, ethnicity, and …

Readiness For The New Science Teks: A Needs Assessment, Roxanne Rodriguez

Masters Theses (Archived)

No abstract provided.

An Autistic “Linguatype”? Neologisms, New Words, And New Insights, Emily Zane, Rhiannon Luyster

Emerson Authors, Researchers, & Creators

In this commentary, we present new ideas about autistic neologisms. This essay has two primary goals. First, we argue that an autistic predilection to form neologisms generates intriguing new hypotheses about language in autism, including the possibility that a tendency to use neologisms could be a featural element of an autistic “linguatype” (as in “phenotype”). Second, we suggest that the study of neologism meaning, form, and use can yield insights about a specific speaker and about autistic language, generally. To support both aims, we present the largest collection to date of autistic neologisms. We supply an initial framework for considering …

Topical Lifitegrast Therapy For Dry Eye Disease, Lama Assi, Salim C. Lutfallah, Tsz Wing Yim, Su Hsun Liu, Sharon J. Duffy, Jayne Weiss

School of Medicine Faculty Publications

Objectives: This is a protocol for a Cochrane Review (intervention). The objectives are as follows:. To assess the effectiveness and safety of topical lifitegrast therapy alone or in combination with artificial tears, compared with a placebo, artificial tears alone, or no treatment for dry eye disease.

Bibliometric Analysis Of Colchicine In Cardiovascular Health: Trends, Key Contributors, And Global Collaborations, Meltem Sertbaş, Özlem Özaydin, Habi̇p Yilmaz, Abdullah Emre Güner, Özden Güdük, Nalan Okuroğlu, Ali̇ Özdemir, Yaşar Sertbaş

Turkish Journal of Medical Sciences

Background/aim: The study aims to systematically analyze the body of literature concerning the effects of colchicine on the cardiovascular system, providing a comprehensive evaluation of the current knowledge and highlighting the clinical and scientific relevance of colchicine in this field.

Materials and methods: Data were obtained from the Web of Science Core Collection database on November 17, 2024. The search terms included “Colchicine” AND "Cardiovascular effects" OR "Cardiovascular diseases" OR "Heart diseases" OR "Coronary artery disease" OR "Myocarditis" OR "Pericarditis" OR "Atherosclerosis" OR "Heart failure" OR "Myocardial infarction." No restrictions were applied regarding publication date or language, ensuring the comprehensive …

The Role Of The Hemoglobin-Albumin-Lymphocyte-Platelet (Halp) Score In Deep Neck Infections And Its Relationship With Clinical Parameters, Ayşe Seçi̇l Kayali Di̇nç, Nagi̇han Gülhan Yaşar, Agah Yeni̇çeri̇, Çeti̇n Şahutoğlu, İbrahi̇m Sevi̇m, Meli̇h Çayönü

Turkish Journal of Medical Sciences

Background/aim: Deep neck infections (DNI) are suppurative infections of the cervical spaces, which may lead to life-threatening complications. The HALP score is a laboratory parameter reflecting a patient’s nutritional and inflammatory status. The aim of this study was to compare the HALP scores of patients with DNI with those of a control group. A secondary objective was to investigate the potential relationship between the HALP score and clinical parameters, and to assess its role in determining disease severity.

Materials and methods: The study retrospectively included patients who were hospitalized and treated for DNI. Data were extracted from the hospital’s electronic …

2025-06-20 Agenda Book, Morehead State University. Board Of Regents.

Morehead State Board of Regents Agenda Books and Meeting Minutes

Agenda booklet for the Board of Regents meeting of June 20, 2025, which includes the minutes of the meeting held on March 28, 2025.

Evaluating Leflunomide And Methotrexate Combination Vs. Monotherapy In Rheumatoid And Psoriatic Arthritis, Mete Kara, Gülay Alp, Mete Pekdi̇ker, Sertaç Ketenci̇, Annamaria Porreca, Haluk Ci̇nakli̇

Turkish Journal of Medical Sciences

Background/aim: Methotrexate (MTX) and leflunomide (LEF) are conventional synthetic disease-modifying antirheumatic drugs (DMARDs) commonly used for treating rheumatoid arthritis (RA) and psoriatic arthritis (PsA), either as monotherapies or in combination. This study aimed to compare the adverse effects (AEs) and efficacy of combined use of MTX plus LEF with monotherapy in RA and PsA patients.

Materials and methods: This study included 528 patients (385 RA and 143 PsA) with at least 6 months of follow-up. Disease activity was assessed using DAS-28 CRP and DAPSA, and treatment-related AEs were classified based on specific MedDRA categories.

Results: The cumulative incidence of AEs …

Pulmonary Artery Wall Thickness And Systemic Sclerosis: Influence Of Inflammation On Vascular Changes, Eli̇f Altunel Kilinç, Haydar Ali̇ Candan, İpek Türk, Çağlar Özmen

Turkish Journal of Medical Sciences

Background/aim: Systemic sclerosis (SSc) is a complex autoimmune disease characterized by vascular disorders and fibrosis. This study aimed to compare pulmonary artery wall thickness (PAWT) in SSc patients without PAH with idiopathic PAH (IPAH) and healthy controls and to investigate the effect of increased PAWT and inflammation on vascular changes in SSc patients.

Materials and Methods: This cross-sectional study included 60 SSc patients, 30 IPAH patients, and 40 age- and sex-matched healthy controls, all of whom underwent echocardiographic evaluation. Data were analyzed including patient demographics, disease duration, type of skin involvement, lung involvement, and autoantibody status.

Results: PAWT was significantly …

Evaluation And Validation Of 3d-Printed Anatomical Urinary System Model And Virtual Reality Rirs Simulators In Rirs Training: A Comparative Study, Mehmet Ezer, Tahsi̇n Batuhan Aydoğan, Lazaros Tzelves, Andreas Skolarikos, Mehmet Uslu, Kemal Sarica, Emre Huri̇

Turkish Journal of Medical Sciences

Background/aim: This study evaluates the use of a 3D-printed anatomical urinary system model (3D-AUSM) and a Virtual Reality RIRS Simulator (VRRS), for training in RIRS, based on real user feedback.

Materials and methods: The 3D-AUSM was created using cadaver CT and MRI scans, and the data was transferred to a VR environment for simulation. A total of 43 inexperienced urology trainees participated in the theoretical phase of the RIRS training program. Of these, 32 trainees (Group T) who passed a proficiency exam proceeded to the hands-on training phase with the 3D-AUSM and VRRS models. Additionally, 17 experienced surgeons (Group S) …

Profile Of Perinatal Infections Among Abandoned Neonates Admitted In A Tertiary Hospital In Oman, Mahmood Dhahir Al-Mendalawi

Sultan Qaboos University Medical Journal

No abstract provided.

Effect Of Ear Health, Care Practices, And Hearing Loss On Academic Performance Among Male Adolescents In Residential Schools: A Cross-Sectional Study In Eastern India, Sumeet Angral, Bijit Biswas, Ksbs Krishna Sasanka, Gulistan Bano

Sultan Qaboos University Medical Journal

Objectives: This study aimed to investigate the association between ear health, ear care practices, and academic performance among male adolescents in residential schools.Methods: A cross-sectional study was conducted among 684 male adolescents residing in residential schools in Deoghar, Jharkhand, India, during World Hearing Day 2023. Data were collected on socio-demographic characteristics, ear care practices, and academic performance. Comprehensive ear examinations and pure tone audiometry were performed to assess ear morbidity and hearing thresholds.Results: Ear morbidity was identified in 43% of participants, with bilateral involvement in 85% of these cases. Ear-related symptoms were reported by 26.3% of participants, including …

Soil Water Contents Affect The Physiological Traits Of Duku Undergoing Sudden Death Disease, In Jambi, Islah Hayati, Sosiawan Nusifera, Mapegau Mapegau, Budiyati Ichwan, Marlina Marlina, Nasamsir Nasamsir

Baghdad Science Journal

Duku, also known as Lancium domesticum Corr, is a plant native to Jambi Province, Indonesia, which is currently facing a sudden death disease. The plant generally grows in the alluvial of the Batanghari River, which is among the widest and longest rivers in Indonesia. Duku is consumed as a fresh fruit that tastes sweet and contains many antioxidants. The phenomenon of duku disease has the potential to cause scarcity, as its population continues to decline. The disease begins with root rot and is prevalent in areas that are often flooded due to the overflow of the Batanghari River. This study …

Influence Percentage Of Additive Materials On The Structural And Physical Characteristics Of Nickel Metal Using Thermal Spraying By Flame, Mohammed M. Hameed, Salih Y. Darweesh, Amer Sh. Mahmood

Baghdad Science Journal

The method of thermal spraying with flame, which was used to conduct a coating consisting of a nickel base and additions of three groups—(C=Ni-WC-B4C), (B=Ni-B4C), and (A=Ni-WC)—and with different reinforcement ratios from these groups, forms the basis of cermet coating. The bases for thermal spraying were made by roughing up and cutting out-of-service turbine blades that were 1 cm square in shape. The spray angle 90°, spray distance of 15 cm, thermal sintering temperature of 1050°C, and mixing ratio of type (C=50%Ni-25%WC-25%B4C) of the three mixes were at their ideal standard conditions. The results of the scanning electron microscope showed …

The Role Of Fear And Predator Dependent Refuge On A Stage Structure Prey-Predator System, Ghaith Jassim Abdulsada, Hiba Abdullah Ibrahim

Baghdad Science Journal

The present paper investigates the role of fear and predator dependent refuge in the prey-predator system. The system describes the interaction between prey and a stage structure of predator that incorporates Holling II functional response. The predator splits into two compartments immature (juvenile) and mature (adult). The mature predators can hunt and reproduce but this capability is not found in the immature predators, the immature depend on their parents. The growth rate of prey decreases due to the existence of mature predators. The existence, uniqueness, and boundedness of the solution of the system are investigated. Three equilibrium points of the …

Applying Ceragenins In Translational Medicine: Activating Mesenchymal Stem Cells And Preventing Healthcare-Associated Infections, Aaron L. Zaugg

Theses and Dissertations

Healthcare-associated infections are a major global concern. Increased infections among vulnerable populations lead to millions of deaths, annually, complicated by the emergence of multi-drug resistant pathogens. These infections are often facilitated by medical devices serving as abiotic surfaces that facilitate the formation of biofilms. Notably, colonization of prostheses and other bone-associated medical devices can lead to corrective procedures, revisions and death. To address these issues, inspiration can be drawn from natural sources of bone health and defenses against infection. Cathelicidins are endogenous peptides involved in both bone maintenance and infection control. Ceragenins are small molecule mimics of cathelicidins with broad …

Relation Between Executive Functions, Ruminative Thinking Style, And Internalizing Symptoms In Neurodivergent Individuals., John Strom

Clinical Psychology Dissertations

Introduction: Neurodevelopmental disorders (NDD) are among the most common psychological disorders occurring in childhood (Bishop, 2010; Scandurra et al., 2019), and are commonly associated with a host of psychological challenges including deficits in executive functioning (Craig et al., 2016; Demetriou et al., 2019) as well as comorbid internalizing disorders such as depression and anxiety (Katzman et al., 2017; Kirsch et al., 2020; Simonoff et al., 2008). Research has suggested that executive function deficits may contribute to symptoms of depression and anxiety and that this relation may be mediated by ruminative thinking styles (Snyder et al., 2019; von Hippel et al., …

Invisible Intersections: Race, Adhd, And The Role Of Disciplinary Actions In Academic Outcomes, Miles Feller

Clinical Psychology Dissertations

Race is a marginalized identity linked to significant achievement gaps for Black and Latino students in the USA (de Bray et al., 2019). These students experience higher rates of exclusionary school discipline (ESD) than White and Asian peers (Aud et al., 2010; de Bray et al., 2019), with suspensions correlating to lower academic performance (Del Toro & Wang, 2022; Wang et al., 2023; Owens & Hinshaw, 2016). Additionally, developmental disabilities like ADHD intersect with these issues; despite narrowing racial disparities in diagnoses (Cénat et al., 2022; Fairman et al., 2020), access to treatment remains uneven (Baglivio et al., 2017; Coker …

Evidence And Consensus-Based Imaging Guidelines In Birdshot Chorioretinopathy: Multimodal Imaging In Uveitis (Muv) Taskforce Report 8, Jose S. Pulido

Wills Eye Hospital Papers

PURPOSE: To develop consensus-based imaging guidelines for diagnosing and monitoring birdshot chorioretinopathy (BSCR).

DESIGN: Consensus-based approach guided by literature and an expert committee using a nominal group technique (NGT).

METHODS: An expert committee of 5 international uveitis specialists reviewed 15 well-documented representative BSCR cases with comprehensive imaging data. Cases with active and inactive disease were included. Imaging, including color fundus photography (CFP), fundus fluorescein angiography (FFA), indocyanine green angiography (ICGA), optical coherence tomography (OCT), fundus autofluorescence (FAF), and OCT angiography (OCTA) were reviewed. Using a structured NGT approach, consensus-based recommendations were developed for specific disease characteristics, biomarkers of activity, and …

Strengthening Connections: A Randomized Controlled Trial Examining The Impact Of A Supervisor Support Intervention On Loneliness And Military Couple Relationships, Cynthia D. Mohr, Annamarie S. O'Neill, Jacquelyn M. Brady, Todd E. Bodner, Tori L. Crain, Leslie B. Hammer

Psychology Faculty Publications and Presentations

Social connection has been declining across the general population (i.e., the “loneliness epidemic”), though some groups, including military personnel, are experiencing particularly high rates. This has led to calls for a multilevel national strategy, including workplaces, to build social connection (U.S. Surgeon General, 2023). To answer this call, the present study draws on the wise intervention approach (Walton, 2014), multidimensional model of social connection (Holt-Lunstad, 2022), and models of the bidirectional relationship between sleep health and relationship functioning (Gordon et al., 2017; Troxel et al., 2007), to deliver a workplace intervention that builds social connection for military employees and their …

453 Cent. Park W. Tenant Assn. V. Park Front Apts., Llc

All Decisions

The court denied the landlord's motion for partial summary judgment seeking to dismiss fraud claims in a rent overcharge case. The landlord argued the four-year lookback period could only be pierced for fraudulent schemes to deregulate, not merely overcharge. The court, citing recent Court of Appeals and First Department precedent interpreting a 2024 legislative amendment, held that the fraud exception applies to any "fraudulent scheme to evade the protections of the rent stabilization law," irrespective of whether the unit was deregulated.

Expert Opinion On Clinical Presentation, Diagnosis And Treatment Of Infantile Onset Pompe Disease: A Delphi Study In Türkiye, Eki̇n Özsaydi Aktaşoğlu, Asli İnci̇, Ridvan Murat Öktem, Gürsel Bi̇beroğlu, İlyas Okur, Fati̇h Süheyl Ezgü, Fi̇li̇z Başak Cengi̇z Ergi̇n, Abdurrahman Akgün, Nur Arslan, Hali̇l İbrahi̇m Aydin, Ayşe Ergül Bozaci, Mahmut Çoker, Fatma Tuba Emi̇noğlu, Meli̇ke Ersoy, Emi̇ne Göksoy, Banu Kadioğlu Yilmaz, Mehtap Kağnici, Mustafa Kiliç, Nesli̇han Önenli̇ Mungan, Burcu Öztürk Hişmi̇, Pembe Soylu Üstkoyuncu, Ayşegül Tokatli, Ayşe Çi̇ğdem Aktuğlu Zeybek, Berrak Bi̇lgi̇ner Gürbüz, Sevi̇l Dorum, Di̇lek Güneş, Çi̇ğdem Seher Kasapkara, Sebi̇le Kilavuz, Erdoğan Soyuçen, Peli̇n Teke Kisa, Özlem Ünal Uzun, Fatma Derya Bulut, Songül Gökay, Selen Has Özhan, Deni̇z Kor, Aynur Küçükcongar Yavaş, Fi̇gen Özçay, Yilmaz Yildiz, Harun Yildiz, Leyla Tümer

Turkish Journal of Medical Sciences

Background/aim: Pompe disease (acid maltase deficiency, glycogen storage disease type II, OMIM #606800) is an autosomal recessive disorder characterized by lysosomal acid-α-glucosidase deficiency. The infantile-onset type of the disease is mainly characterized by cardiomegaly, hypotonia, and a high mortality rate. This study aimed to create a national consensus about infantile-onset Pompe disease (IOPD) to raise awareness among clinicians and standardize diagnosis and treatment approaches in Türkiye.

Materials and methods: The Gazi University Division of Metabolic Diseases and Nutrition developed this expert opinion consensus and expanded it to include metabolism specialists across Türkiye. A systematic literature review was performed, and the …

A Meta-Analysis Of The Effects Of Probiotic Supplementation On Type 2 Diabetes Parameters, Mostefa Naimi, Zineb Benmechernene, Méghit Boumédiène Khaled

Baghdad Science Journal

We aimed to assess the effect of probiotic supplementation on type 2 diabetes (T2D) related variables. Randomized controlled trials (RCTs) were systematically searched from PubMed, Springer-link and Scopus data bases published between 2016 and 2020. Collected studies were independently assessed for eligibility, data extracted and evaluated for risk of bias. Statistical analysis was performed using RevMan 5.4.1. The effects of probiotics were assessed for: body mass index (BMI), fasting blood glucose (FBG), glycated hemoglobin (HbA1c), homeostasis, model assessment-estimated insulin resistance (HOMA-IR), insulin, triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), systolic blood pressure (SBP), diastolic …

О Взаимодействии Грамматики И Словаря На Занятиях По Рки: Глаголы Перемещения И Их Лексикографические Толкования / On The Interaction Of Grammar And Vocabulary In Teaching Russian As A L2 (Rki): Motion Verbs And Their Lexicographic Definitions, Svetlana Krylosova

Russian Language Journal

This article examines how lexicographic definitions can be meaningfully integrated into the teaching of Russian grammar within a university-level Russian-as-a-foreign-language curriculum, focusing on the case of paired motion verbs. Drawing on the theoretical framework of Igor Mel’čuk’s Explanatory Combinatorial Lexicology, the study shows how academic dictionary entries can be transformed into learner-friendly tools tailored to the needs of advanced learners. Through a detailed analysis of pedagogically adapted definitions for the verbs letet’ and letat’, the author outlines a step-by-step classroom approach. Particular attention is paid to how semantic distinctions between the verbs are clarified and how common learner difficulties …

Correction: Rationale For A 4-Month, Parallel-Group, Randomized Controlled Trial To Assess The Feasibility And Efficacy Of A Remotely Delivered Exercise Training Intervention For Hispanics/Latinos With Multiple Sclerosis (Ferla Ms), Victoria A Flores, Stephanie L Silveira, David X Marquez, Dominique Kinnett-Hopkins, Augusto Miravalle, Fabian Sierra-Morales, Zulma Hernández-Peraza, Robert W Motl

Faculty, Staff and Student Publications

No abstract provided.

A Study On Covid-19 Outbreak In Cook County Of Illinois, Suraj Powar

Research Papers

This study presents a mathematical model developed to better understand the transmission dynamics of COVID-19 and evaluate the effectiveness of different public health strategies. The model, called SEQIRD, includes of the disease such as exposure, quarantine, infection, recovery, and death. Using real case and death data from Cook County, Illinois, the model closely fits observed trends and captures both pre and post-lockdown dynamics with high accuracy.

Our results show that early intervention significantly reduces total infections, with lockdown imposed even a few days earlier preventing thousands of cases. Through sensitivity analysis, we also identify that parameters such as transmission rate, …

A Core Curriculum For Sociology In Undergraduate Medical Education (2nd Edition), Tracey Collett, Kathleen Kendall, Jeni Harden

Peninsula Medical School

No abstract provided.

Characterization And Clinical Implications Of P53 Dysfunction In Patients With Myelodysplastic Syndromes, Matteo Zampini, Elena Riva, Luca Lanino, Elisabetta Sauta, Rita Antunes Dos Reis, Rosa Maria Andres Ejarque, Giulia Maggioni, Alberto Termanini, Alessandra Merlotti, Alessia Campagna, Lorenzo Dall'olio, Austin Kulasekararaj, Michela Calvi, Clara Di Vito, Arturo Bonometti, Daoud Rahal, Giorgio Croci, Emanuela Boveri, Umberto Gianelli, Maurilio Ponzoni, Rossella Caselli, Serena Albertazzi, Gabriele Todisco, Marta Ubezio, Laura Crisafulli, Alessandro Frigo, Enrico Lugli, Ettore Mosca, Pamela Acha, Serena Ghisletti, Francesco Nicassio, Armando Santoro, Maria Diez-Campelo, Francesc Solé, Lionel Ades, Uwe Platzbecker, Valeria Santini, Pierre Fenaux, Torsten Haferlach, David Sallman, Guillermo Garcia-Manero, Domenico Mavilio, Daniel Remondini, Gastone Castellani, Saverio D'Amico, Amer M Zeidan, Rami Komrokji, Shahram Kordasti, Francesca Ficara, Matteo Giovanni Della Porta, Calr Consortium

Faculty, Staff and Student Publications

Purpose: Tumor Protein 53 (p53) expressed from gene TP53 is a seminal tumor suppressor. We aimed to characterize mutational and nonmutational mechanisms of p53 dysfunction in myelodysplastic syndromes (MDS) and to investigate their clinical effect.

Patients and methods: We analyzed a cohort of 6,204 patients with MDS and subsets of patients with available information on RNA sequencing of tumor cells (n = 109), high-dimensional phenotype of immune cells (n = 77), and multiomics analysis (RNA sequencing and proteomics) on single cells (n = 15). An independent validation was performed on 914 patients.

Results: Biallelic TP53 inactivation was a powerful driver …

Turkish Translation, Validity, And Reliability Of The European Organization For Research And Treatment Of Cancer Quality Of Life-High Dose Chemotherapy29 In Patients Undergone Hematopoietic Stem Cell Transplantation, Vesi̇le Yildiz Kabak, Sevi̇lay Karahan, Eli̇fcan Aladağ Karakulak, Tüli̇n Düger, Songül Atasavun Uysal, Fulya İpek-Erdem, Hakan Göker

Turkish Journal of Medical Sciences

Background/aim: Our aim was to investigate psychometric properties of the Turkish version of the European organization for research and treatment of cancer quality of life-high dose chemotherapy29 (EORTC QLQ-HDC29) in patients treated with hematopoietic stem cell transplantation (HSCT).

Materials and methods: Patients between the ages of 18 and 65 years and undergone HSCT were included. The European organization for research and treatment of cancer quality of life questionnaire–cancer30 the Eastern cooperative oncology group performance score, and the functional assessment of cancer therapy–bone marrow transplant were used to determine convergent validity. Reliability was assessed through the calculation of Cronbach’s alpha and …

Effects Of Lumbar Stabilization Exercises On Serum Biomarker Levels And Clinical Outcomes In Lumbar Disc Herniation: A Subgroup Analysis Of A Randomized Controlled Trial, Bi̇rgül Morkoç, Onur Aktan, Gamze Sönmez, Ebru Bodur, Jale Karakaya, Bayram Kaymak, Sevi̇l Bi̇lgi̇n

Turkish Journal of Medical Sciences

Background/aim: The aim of our study was to investigate the effectiveness of lumbar stabilization exercises on serum biomarker levels and clinical outcomes in lumbar disc herniation (LDH) patients with and without neurological deficit.

Materials and methods: 40 patients with neurological deficits (WND) and 34 patients without neurological deficits (WOND) diagnosed with LDH were included in this study. The patients WND and WOND were randomized into stabilization exercises (SE) and general exercises (GE) groups. Stabilization exercises or general exercises were applied for six weeks. Serum levels of tumor necrosis factor alpha (TNF-α), interleukin (IL)-1β, IL-6, IL-4, beta-endorphin (BE), anandamide (AEA), and …