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Aiding Depth Perception In Initial Drone Training: Evidence From Camera-Assisted Distance Estimation, John Murray, Steven Richardson, Keith Joiner, Graham Wild Jul 2025

Aiding Depth Perception In Initial Drone Training: Evidence From Camera-Assisted Distance Estimation, John Murray, Steven Richardson, Keith Joiner, Graham Wild

Research outputs 2022 to 2026

Remotely Piloted Aircraft (RPA) pilots frequently experience difficulties with depth perception, particularly when estimating distances between the drone and environmental obstacles. This study evaluates whether the use of onboard camera imagery can improve exocentric distance estimation accuracy among ab initio drone pilots operating under visual line-of-sight (VLOS) conditions. Two groups of undergraduate students performed distance estimation tasks at 20 and 50 m. One group used direct observation only to estimate the exocentric distance between the drone and an obstacle. The second group, as well as direct observation, had access to a live video feed from the drone’s onboard camera via …


A Study On The Multifunctional Properties And Application Perspectives Of Zno/Sic Composite Materials, Mohammad Nur-E-Alam Jul 2025

A Study On The Multifunctional Properties And Application Perspectives Of Zno/Sic Composite Materials, Mohammad Nur-E-Alam

Research outputs 2022 to 2026

ZnO/SiC nanocomposite materials possess significant potential for various technological fields due to their extraordinary optical, electrical, thermal, and mechanical properties. The synthesis methods, material properties, and diverse applications of ZnO/SiC composites have been systematically explored in this study. The potential application areas of this nanocomposite include their roles in photocatalysis, optoelectronic devices, gas sensors, and photovoltaic systems. The synergetic effects of ZnO and SiC are analyzed to highlight their advantages over their individual components. Future research directions must focus on the remaining challenges to optimize these nanoscale composite materials for industrial and emerging applications.


Models Of Care For Indigenous Children In Rural And Remote Settings: A Global Scoping Review, Joseph Freeman, Thomas Stubbs, Verity Chadwick, Anita Pickard, Tuguy Esgin, Elizabeth J. Elliott, Alexandra Martiniuk Jul 2025

Models Of Care For Indigenous Children In Rural And Remote Settings: A Global Scoping Review, Joseph Freeman, Thomas Stubbs, Verity Chadwick, Anita Pickard, Tuguy Esgin, Elizabeth J. Elliott, Alexandra Martiniuk

Research outputs 2022 to 2026

Indigenous communities internationally have demonstrated remarkable strength despite significant challenges. Health disparities among Indigenous peoples persist due to historical injustices and ongoing racial discrimination, not inherent vulnerabilities. Disparities are rooted in a legacy of colonisation, systemic exclusion, and socio-economic inequities impacting access to healthcare, education, and employment. Preliminary searches show limited literature on models of care for remote living Indigenous children. This review aimed to identify internationally, effective models of care for Indigenous children in rural and remote areas. A scoping review was conducted, analysing literature on models of care for remote Indigenous children. This study followed the JBI’s Scoping …


Annual Report City Of Nashua, New Hampshire For The Fiscal Year Ended June 30, 2025, Nashua Town Representatives Jul 2025

Annual Report City Of Nashua, New Hampshire For The Fiscal Year Ended June 30, 2025, Nashua Town Representatives

Nashua, NH Annual Reports

This is an annual report containing vital statistics for a town/city in the state of New Hampshire.


An Exhibition And Protest Of Executions In Iran, Donna M. Hughes Jul 2025

An Exhibition And Protest Of Executions In Iran, Donna M. Hughes

Dignity: A Journal of Analysis of Exploitation and Violence

An exhibition and protest of executions in Iran was held in Washington, D.C. in June 2025. Portraits of 2000 men and women who were killed or executed in Iran since the 1980s were displayed on the National Mall in front of the Capitol. The Iranian Resistance estimates that 30,000 activists were massacred in one period in 1988. Executions of prisoners have continued steadily, making Iran the world’s leading executioner of men and women. In recent years, there has been a sharp escalation in the number of executions of prisoners. A United Nations Special Rapporteur reported that over 800 persons were …


2025 July, Morehead State University. Office Of Communications & Marketing. Jul 2025

2025 July, Morehead State University. Office Of Communications & Marketing.

Morehead State Press Release Archive, 1961 to the Present

Press releases for July of 2025.


Subclinical Hyperthyroidism Presenting As Urinary Frequency And Polyuria: A Case Report., Hameed H Salah, Elizabeth M Pines Jul 2025

Subclinical Hyperthyroidism Presenting As Urinary Frequency And Polyuria: A Case Report., Hameed H Salah, Elizabeth M Pines

Ambulatory and Primary Care Articles

Hyperthyroidism may present with a variety of symptoms including urinary frequency. This report discusses a case of subclinical hyperthyroidism presenting as generalized weakness, urinary frequency, polyuria, and intermittent diarrhea. However, this elderly patient had a complex past medical history including multinodular nontoxic thyroid goiter with tracheal deviation and multiple recent admissions for aspiration pneumonia, making the diagnosis of subclinical hyperthyroidism less obvious. The patient was managed with intravenous fluids and discharged on propranolol with recommendations to follow-up with endocrinology. This case demonstrates the importance of keeping hyperthyroidism on the differential for urinary frequency and polyuria without other clear etiologies.


Justice Making, Justice Spaces And Justice Users, Dean D' Cruz, Reboni Saha, Siddhrath Peter De Souza, Varsha Aithala, Naomi Jose, Sharada Kerkar Jul 2025

Justice Making, Justice Spaces And Justice Users, Dean D' Cruz, Reboni Saha, Siddhrath Peter De Souza, Varsha Aithala, Naomi Jose, Sharada Kerkar

Books

This insightful book reimagines how justice systems can be reshaped to better serve the needs of people—especially those who are disadvantaged. Focusing on public spaces in Goa—courtrooms, police stations, protest sites, and classrooms—it asks how these spaces are structured, and what must change for them to truly support those seeking justice.

Drawing on insights from practitioners, activists, and researchers, the authors explore how ordinary people relate to these spaces and the barriers they face. Through grounded case studies and theoretical reflections, the chapters of this work offer a wider commentary on how we might design justice systems that are more …


Empowering Weight Loss: A Pragmatic Randomized Controlled Trial Of A Theory-Driven Self-Regulation Mobile App For Young Adults With Excess Body Weight, H. S. J. Chew, J. W. Ngooi, R. C. Du, P. Z. Chan, M. Jansson, B. Zhu, Y. Cao, Chong-Wah Ngo, R. Foo, A. Shabbir, D. Ho, N. Sevdalis, K. Y. Ngiam Jul 2025

Empowering Weight Loss: A Pragmatic Randomized Controlled Trial Of A Theory-Driven Self-Regulation Mobile App For Young Adults With Excess Body Weight, H. S. J. Chew, J. W. Ngooi, R. C. Du, P. Z. Chan, M. Jansson, B. Zhu, Y. Cao, Chong-Wah Ngo, R. Foo, A. Shabbir, D. Ho, N. Sevdalis, K. Y. Ngiam

Research Collection School Of Computing and Information Systems

Background/Introduction: Obesity is projected to affect more than half of the global population by 2035, posing significant health and economic challenges. While lifestyle modification is considered a cornerstone of weight management, its effectiveness often relies on substantial support systems. Purpose: This study aimed to evaluate the effectiveness of a 12-week, standalone Temporal Self-Regulation Theory (TST)-based weight loss mobile application, which integrates self-regulation techniques, food logging, and dietary nudging, in promoting weight loss among young adults with excess body weight. Methods: A two-arm, parallel-group, 1:1 randomized controlled trial was conducted, adhering to the CONSORT-Outcomes 2022 Extension guidelines. Participants completed a face-to-face …


Cracking Aegis: An Adversarial Llm-Based Game For Raising Awareness Of Vulnerabilities In Privacy Protection, Jiaying Fu, Yiyang Lu, Zehua Yang, Fiona Fui-Hoon Nah, Ray Lc Jul 2025

Cracking Aegis: An Adversarial Llm-Based Game For Raising Awareness Of Vulnerabilities In Privacy Protection, Jiaying Fu, Yiyang Lu, Zehua Yang, Fiona Fui-Hoon Nah, Ray Lc

Research Collection School Of Computing and Information Systems

Traditional methods for raising awareness of privacy protection often fail to engage users or provide hands-on insights into how privacy vulnerabilities are exploited. To address this, we incorporate an adversarial mechanic in the design of the dialogue-based serious game Cracking Aegis. Leveraging LLMs to simulate natural interactions, the game challenges players to impersonate characters and extract sensitive information from an AI agent, Aegis. A user study (n=22) revealed that players employed diverse deceptive linguistic strategies, including storytelling and emotional rapport, to manipulate Aegis. After playing, players reported connecting in-game scenarios with real-world privacy vulnerabilities, such as phishing and impersonation, and …


A Recycling Route For E-Waste And Aluminium Scrap To Produce A2xxx And A3xx Al Alloys, Iman El-Mahallawi, Shaza Raji, Mayar M. Ali, Mai Mahmoud, Sara Atef, Mahmoud Tash, Serag Salem, Tarek Elmeligy Jul 2025

A Recycling Route For E-Waste And Aluminium Scrap To Produce A2xxx And A3xx Al Alloys, Iman El-Mahallawi, Shaza Raji, Mayar M. Ali, Mai Mahmoud, Sara Atef, Mahmoud Tash, Serag Salem, Tarek Elmeligy

Mechanical Engineering

Electronic waste (e-waste) generation is significantly escalating, while traditional recycling methods, failing to meet sustainability criteria, are still used. The implementation of sustainability requirements calling for recycling will not be achieved unless intensive research is conducted for mitigating and tolerating the presence of accumulating tramp elements in the recycled alloys and even revising the existing standard specifications. This study explores an innovative approach to recycling electronic waste (e-waste) by integrating it with aluminum scrap through conventional melting techniques to produce high-performance industrial alloys aiming to develop novel aluminum alloys with enhanced properties suitable for various industrial applications. The experimental process …


Wild Hogs In The Water: Contested Infrastructural Ecologies Of Reservoir Storage In Texas, Sayd Randle Jul 2025

Wild Hogs In The Water: Contested Infrastructural Ecologies Of Reservoir Storage In Texas, Sayd Randle

Research Collection College of Integrative Studies

Reservoirs are developed to store water in reserve for future use. But once built, reservoir sites inevitably hold more than just water, often serving as a key habitat for a range of species. This paper examines how one such animal has transformed water storage facilities and nearby landscapes into contested ground in urbanising areas of Texas, USA. Living around the reservoirs, feral hogs complicate the process of urbanisation by degrading the stockpiled water and infrastructure at the storage sites themselves and by damaging private property throughout the surrounding landscape. Tracking local efforts to manage the hogs, the case study illustrates …


Political Ecologies Of Storage For The 21st Century, Sayd Randle, Matthew Archer Jul 2025

Political Ecologies Of Storage For The 21st Century, Sayd Randle, Matthew Archer

Research Collection College of Integrative Studies

New resource storage arrangements are proliferating rapidly both in terms of physical infrastructures-for the storage of things like "clean" energy, nuclear waste, carbon dioxide, fresh water, and data-and as part of a set of discursive moves that reinforce a vision of a near future world in which problems of climate change mitigation and adaptation in particular (but also issues like energy security, water security, industry growth, etc.) are solved through eco-modernist techno-fixes. This Symposium sketches the contours of a framework we term political ecologies of storage. In doing so, we treat storage as both a potent imaginary and a concrete …


Singapore At 60: Home Truly Is An Idea That Never Stands Still, Lily Kong Jul 2025

Singapore At 60: Home Truly Is An Idea That Never Stands Still, Lily Kong

Research Collection School of Social Sciences

There are many new stories to embrace but also quiet distances between us that we must bridge.

In a National Day op-ed published in The Straits Times, SMU President Professor Lily Kong reflects on what ‘home’ means as Singapore marks its 60th year of independence — and how that meaning continues to evolve across generations. Prompted by a walk through a familiar playground now transformed, Prof Kong considers how Singapore’s changing physical and social landscape mirrors shifts in national identity. While progress and policy evolution signal a society in transition, she also notes the emergence of quieter divides – between …


Calibrated Structures Of Feeling: Cultural Citizenship And The Reproduction Of The Military In Singapore, John Lowe, George Wong Jul 2025

Calibrated Structures Of Feeling: Cultural Citizenship And The Reproduction Of The Military In Singapore, John Lowe, George Wong

Research Collection School of Social Sciences

This article discusses the nexus between Raymond Williams’ structure of feelings and the reproduction of military masculinity as cultural citizenship. By placing the gaze upon National Service in the Singapore Armed Forces as a rite of passage into manhood, this work uses representations of the military in popular culture and souvenirs/ephemera to elucidate how structures of feeling are calibrated as masculinity the state wants its citizenry to internalize. These render military masculinity emergent for Singaporean male bodies. With the male body functioning as an important edifice of the military, emotions toward military service are the connective tissue between enactments of …


Governing Migration, Producing Skills: Emigration And Education In The Philippines, Yasmin Y. Ortiga, Roderick. Galam Jul 2025

Governing Migration, Producing Skills: Emigration And Education In The Philippines, Yasmin Y. Ortiga, Roderick. Galam

Research Collection School of Social Sciences

This article examines skill as an integral yet understudied aspect of emigration governance. To date, migration studies have mainly focused on how the demand for migrant skills drive people's movements across borders, shaping the conditions for entry into popular destinations in the West. In contrast, less is known as to how skills also shape the way governments manage emigration, pushing would-be migrants to acquire certain capacities well before they leave their countries of origin. Drawing from the case of the Philippines, this article discusses how state agencies have used skills training to dominate specific markets for migrant professionals and demand …


Stockpiling, Forecasting And Protecting Skills: Skilling As Technique Of Preparedness In Times Of Crises, Rebecca Ye, Yasmin Y. Ortiga Jul 2025

Stockpiling, Forecasting And Protecting Skills: Skilling As Technique Of Preparedness In Times Of Crises, Rebecca Ye, Yasmin Y. Ortiga

Research Collection School of Social Sciences

In this comparative and situational analysis, we examine how nation-states use skilling as a technique of preparedness during crisis moments. By analysing two strategically selected country cases, Singapore and Sweden, during a critical phase of a global pandemic, we identify three techniques: stockpiling, forecasting, and protecting skills, and how these were enacted as a means to perform preparedness. Stockpiling skills was observed to take place as a rapid response; forecasting skills was a technique enacted with a view on the longer-term horizon and protecting skills was mobilised as a short-term future technique, where boundaries were assembled around skilling. While there …


Religious Beliefs, Cooperation, And Evolutionary Mechanisms, Nicole Fellice Ko, Norman P. Li Jul 2025

Religious Beliefs, Cooperation, And Evolutionary Mechanisms, Nicole Fellice Ko, Norman P. Li

Research Collection School of Social Sciences

Religion is an organized system of spiritual beliefs, practices, and rituals that often involve a sense of the divine (Schilbrack, 2022). An evolutionary mechanism is an evolved set of traits that interpret environmental inputs and generate behavioral responses that enhance survival or reproductive success (Li et al., 2018). Cooperation refers to the act of individuals or groups working together to achieve a shared goal or mutual benefit (Alós-Ferrer & Garagnani, 2020).


The Role Of Private Law In Promoting Building Safety: The Case Of Singapore, Edward S. W. Ti Jul 2025

The Role Of Private Law In Promoting Building Safety: The Case Of Singapore, Edward S. W. Ti

Research Collection Yong Pung How School Of Law

Singapore is a tiny granite rock situated just north of the equator. Lacking land, and indeed any kind of natural resource, means that the trend for urban development in the city-state will always be densifi cation; 96 per cent of residents in Singapore already live in multi-owned housing, ie high-rise apartments. 1 Singapore is also a rapidly greying nation. 2 It has been observed that persons over 70 years old are four times more vulnerable in the event of a fi re, 3 and fi re safety is a critical aspect of building safety. Safety features and measures in the …


The Miseducation Of Model Minorities: The Gospel Of ‘Schoolvation’ And The Myth Of The Schooled Society, Justin Kh Tse Jul 2025

The Miseducation Of Model Minorities: The Gospel Of ‘Schoolvation’ And The Myth Of The Schooled Society, Justin Kh Tse

Research Collection College of Integrative Studies

The ‘model minority’, the phenomenon of some ‘minority’ communities (or some members within them) achieving social and economic advancement despite encountering the difficulties of assimilating into a mainstream society, is often described as a myth, especially as one of the central problematics in Asian American studies. Usually, the modern use of the word myth is pejorative: the model minority in this sense refers to a false empirical description of some minorities and should be quantitatively disaggregated and qualitatively debunked. In this article, I want to explore the model minority as another kind of myth, in the classical sense of mythos, …


Do Supplier Ceo's National Cultural Origins Affect Supplier-Customer Relationships?, Peng Liang, Hasan Cavusoglu, Nan Hu Jul 2025

Do Supplier Ceo's National Cultural Origins Affect Supplier-Customer Relationships?, Peng Liang, Hasan Cavusoglu, Nan Hu

Research Collection School Of Computing and Information Systems

This study investigates how the national cultural origins of supplier chief executive officers (CEOs), as characterized by Hofstede’s cross-cultural dimensions, influence the duration of supplier–customer relationships. By analyzing the cultural origins of supplier CEOs from 20 countries over a 25-year period, we find that supplier CEOs with high long-term orientation (LTO) and high uncertainty avoidance (UNA) are associated with longer lasting supplier–customer relationships, while those with high individualism (IND) are associated with shorter relationship durations. These findings are robust to several alternative explanations of customer and supplier CEO variables. To address potential endogeneity—specifically, the concern that CEOs with certain cultural …


Cardiovascular Manifestations Of Pseudoxanthoma Elasticum., Aimee Willett, Vivek V Jasti, Sean M Muir, Jay Anderson Jul 2025

Cardiovascular Manifestations Of Pseudoxanthoma Elasticum., Aimee Willett, Vivek V Jasti, Sean M Muir, Jay Anderson

Ambulatory and Primary Care Articles

Pseudoxanthoma elasticum (PXE) is a rare systemic disorder of elastic fibers. The most common manifestations include characteristic papules and ocular angioid streaks. Cardiovascular complications include peripheral arterial disease, hypertension, premature coronary artery disease, and cerebrovascular disease. These associations are secondary to dystrophic elastic fibers, resulting in the calcification of small- to medium-sized arteries. We present the case of a 22-year-old otherwise healthy female patient diagnosed with PXE following a biopsy of a neck lesion. Ophthalmologic evaluation revealed characteristic angioid streaks. The patient also reported early satiety and leg cramping, which prompted referral to gastroenterology and cardiology. Further investigation raised concern …


The Experience Of Codependency In Young Adult Romantic Relationships, Amanda S. Soares Jul 2025

The Experience Of Codependency In Young Adult Romantic Relationships, Amanda S. Soares

Undergraduate Theses and Capstone Projects

This qualitative study used Interpretative Phenomenological Analysis (IPA) to explore the lived experiences of codependency among four young adults (ages 21–24) who had recently exited a codependent romantic relationship. Through in-depth interviews, themes around emotional enmeshment, identity loss, boundary erosion, emotional suppression, and healing were found. Findings indicate that early attachment patterns, trauma, and socialization intersect with emotional vulnerability and self-worth to create conditions ripe for codependent dynamics. Participants describe both the psychological toll of these relationships and the personal growth that followed. These insights contribute to the limited literature on young adult codependency and may inform prevention and intervention …


Manufactured Superiority: The War On Terror, United States Dominated Media, And The Global Implications Of American Exceptionalism, Ayan Mohamed Jul 2025

Manufactured Superiority: The War On Terror, United States Dominated Media, And The Global Implications Of American Exceptionalism, Ayan Mohamed

Undergraduate Theses and Capstone Projects

This research examines American exceptionalism and its effects on the global perception of the United States, specifically how it shapes international narratives, marginalizes alternative perspectives, and reinforces a ruling American worldview that inhibits effective engagement and cross-cultural dialogue. The study will focus on two key areas: U.S. military interventions and media representation. First, it will analyze the War on Terror in Afghanistan and Iraq (2001–2021), assessing how U.S.-enforced destabilization in the region perpetuates hegemonic control. Second, it will investigate U.S.-backed, Israel-led Palestinian erasure as a case study of interventionism that positions the U.S. as the self-designated enforcer of global order. …


Outcomes And Toxicity Following 3 Or More Definitive Courses Of Thoracic Radiation Therapy For Non-Small Cell Lung Cancer, Abigael Odwuor, Percy Lee, Joe Y Chang, Saumil Gandhi, Zhongxing Liao, Steven H Lin, Aileen Chen, Quynh-Nhu Nguyen, Michael S O'Reilly, Stephen G Chun, Julianna Bronk, David Qian, Matthew S Ning Jul 2025

Outcomes And Toxicity Following 3 Or More Definitive Courses Of Thoracic Radiation Therapy For Non-Small Cell Lung Cancer, Abigael Odwuor, Percy Lee, Joe Y Chang, Saumil Gandhi, Zhongxing Liao, Steven H Lin, Aileen Chen, Quynh-Nhu Nguyen, Michael S O'Reilly, Stephen G Chun, Julianna Bronk, David Qian, Matthew S Ning

Faculty, Staff and Student Publications

Purpose: Salvage re-irradiation is increasingly utilized to manage non-small cell lung cancer (NSCLC) locoregional recurrence or new lung primaries in previously treated areas. There is sparse information on efficacy and toxicity profile. We report a large experience of patients treated with multiple courses of definitive radiation for new and recurrent NSCLC.

Methods and materials: Medical records of patients who underwent ≥ 3 definitive thoracic radiation therapy (RT) courses for new or recurrent NSCLC at our cancer center from 2012 through 2021 were retrospectively reviewed following institutional review board approval. Toxicity was graded per Common Terminology Criteria for Adverse Events (CTCAE) …


Boundary-Setting And Choice-Making With No "Adult" In The Room: Professional Identity Formation Opportunities For 1ls In The Transactional Context, Marni Goldstein Caputo, Kathleen Luz Jul 2025

Boundary-Setting And Choice-Making With No "Adult" In The Room: Professional Identity Formation Opportunities For 1ls In The Transactional Context, Marni Goldstein Caputo, Kathleen Luz

Faculty Scholarship

Law schools are now required by the American Bar Association’s Standard 303(b)(3) to provide students with opportunities for professional identity formation throughout their legal education. It is critical that those opportunities be well-balanced and tied to the realities of practice. Yet until recently, we, as 1L lawyering skills professors at Boston University School of Law, only provided those opportunities in the litigation context. Further, our 1L lawyering skills curriculum was, since its inception, almost entirely steeped in litigation. This litigation focus matches neither the career trajectory nor the upper-level experiential opportunities of the majority of our students. In fact, transactional …


Ovarian Cancer Risk And Survival According To Tumor Sex Hormone Receptor Expression: An Ovarian Cancer Association Consortium And Ovarian Tumor Tissue Analysis Consortium Pooled Analysis, Zhuxuan Fu, Lauren Borho, Sarah E Taylor, Linda E Kelemen, Anna Defazio, Penelope M Webb, Martin Köbel, Nicola S Meagher, Renhua Na, Antonis C Antoniou, Alison H Brand, Catherine J Kennedy, Nikilyn Nevins, Paul D P Pharoah, Yurii B Shvetsov, Stacey J Winham, Jennifer Alsop, Matthias W Beckmann, Adelyn Bolithon, Jessica Boros, David D L Bowtell, James D Brenton, Michael E Carney, Anita Chudecka-Głaz, Linda S Cook, Cezary Cybulski, Peter A Fasching, Sian Fereday, Renée T Fortner, María J García, Ellen L Goode, Marc T Goodman, Jacek Gronwald, Arndt Hartmann, Brenda Y Hernandez, Estrid Høgdall, David G Huntsman, Allan Jensen, Mercedes Jimenez-Linan, Janine M Joseph, Beth Y Karlan, Ewa Kaznowska, Susanne K Kjaer, Tomasz Kluz, Jennifer M Koziak, Jenny Lester, Teri A Longacre, Maria Lycke, Valerie Mcguire, Kirsten B Moysich, Rachel A Murphy, Sandra Orsulic, Susan J Ramus, Cristina Rodríguez-Antona, Joseph H Rothstein, Spinder Samra, Weiva Sieh, Helen Steed, Karin Sundfeldt, Aline Talhouk, Jan Uciński, Chen Wang, Nicolas Wentzensen, Alice S Whittemore, Lynne R Wilkens, Thomas Songer, Maria Mori Brooks, Lu Tang, Francesmary Modugno Jul 2025

Ovarian Cancer Risk And Survival According To Tumor Sex Hormone Receptor Expression: An Ovarian Cancer Association Consortium And Ovarian Tumor Tissue Analysis Consortium Pooled Analysis, Zhuxuan Fu, Lauren Borho, Sarah E Taylor, Linda E Kelemen, Anna Defazio, Penelope M Webb, Martin Köbel, Nicola S Meagher, Renhua Na, Antonis C Antoniou, Alison H Brand, Catherine J Kennedy, Nikilyn Nevins, Paul D P Pharoah, Yurii B Shvetsov, Stacey J Winham, Jennifer Alsop, Matthias W Beckmann, Adelyn Bolithon, Jessica Boros, David D L Bowtell, James D Brenton, Michael E Carney, Anita Chudecka-Głaz, Linda S Cook, Cezary Cybulski, Peter A Fasching, Sian Fereday, Renée T Fortner, María J García, Ellen L Goode, Marc T Goodman, Jacek Gronwald, Arndt Hartmann, Brenda Y Hernandez, Estrid Høgdall, David G Huntsman, Allan Jensen, Mercedes Jimenez-Linan, Janine M Joseph, Beth Y Karlan, Ewa Kaznowska, Susanne K Kjaer, Tomasz Kluz, Jennifer M Koziak, Jenny Lester, Teri A Longacre, Maria Lycke, Valerie Mcguire, Kirsten B Moysich, Rachel A Murphy, Sandra Orsulic, Susan J Ramus, Cristina Rodríguez-Antona, Joseph H Rothstein, Spinder Samra, Weiva Sieh, Helen Steed, Karin Sundfeldt, Aline Talhouk, Jan Uciński, Chen Wang, Nicolas Wentzensen, Alice S Whittemore, Lynne R Wilkens, Thomas Songer, Maria Mori Brooks, Lu Tang, Francesmary Modugno

Faculty, Staff and Student Publications

Objective: Many epithelial ovarian cancer (EOC) risk factors relate to sex hormones. The association between these factors and the expression of androgen receptor (AR), estrogen receptor-α (ER), and progesterone receptor (PR) in tumors is unknown.

Method: We linked epidemiologic, AR/ER/PR tumor expression, and survival data from 19 studies in the Ovarian Cancer Association Consortium (OCAC; 4762 cases, 20,888 controls) and the Ovarian Tumor Tissue Analysis (OTTA) consortium (5737 cases). We estimated odds ratios (ORs) and 95 % confidence intervals (CIs) between hormonally-linked factors and tumor AR/ER/PR expression using polytomous logistic regression. We assessed survival by AR/ER/PR tumor expression overall and …


Renal G Protein-Coupled Estrogen Receptor 1 Regulates The Epithelial Sodium Channel Promoting Natriuresis To A Greater Extent In Females, Victoria L Nasci, Jean C Bopassa, Elena Mironova, Megan Rhoads, Ravneet Singh, Dennis P Buehler, David M Pollock, Oleh M Pochynyuk, James D Stockand, Eman Y Gohar Jul 2025

Renal G Protein-Coupled Estrogen Receptor 1 Regulates The Epithelial Sodium Channel Promoting Natriuresis To A Greater Extent In Females, Victoria L Nasci, Jean C Bopassa, Elena Mironova, Megan Rhoads, Ravneet Singh, Dennis P Buehler, David M Pollock, Oleh M Pochynyuk, James D Stockand, Eman Y Gohar

Faculty, Staff and Student Publications

Hypertension prevalence is lower in women than men. Enhanced renal sodium (Na+) handling in females has been implicated in sex-differences in hypertension. Epithelial Na+ channel (ENaC) is a key contributor to Na+ homeostasis and is regulated by estrogen. Recent evidence suggests G protein-coupled estrogen receptor 1 (GPER1) evokes a female-specific natriuresis that involves endothelin-1 (ET-1). ET-1 has been shown to downregulate ENaC activity, but whether GPER1 regulates ENaC to modulate natriuresis is unknown. We tested the hypothesis that renal GPER1 functionally interacts with ENaC to promote natriuresis in a sex-specific manner. RNAscope confirmed co-expression of GPER1 and ENaC in rat …


First-In-Human Phase 1 Study Of Khk2455 Monotherapy And In Combination With Mogamulizumab In Patients With Advanced Solid Tumors, Timothy A Yap, Olivier Rixe, Capucine Baldini, Ursa Brown-Glaberman, Sergey Efuni, David S Hong, Christophe Massard, Jameel Muzaffar, Andreea Varga, Emrullah Yilmaz, Yuta Ikawa, Lisa H Shiue, Yi Liu, Matthew W Hruska, Henry Zhao, Akihiro Tokunaga, Solmaz Sahebjam Jul 2025

First-In-Human Phase 1 Study Of Khk2455 Monotherapy And In Combination With Mogamulizumab In Patients With Advanced Solid Tumors, Timothy A Yap, Olivier Rixe, Capucine Baldini, Ursa Brown-Glaberman, Sergey Efuni, David S Hong, Christophe Massard, Jameel Muzaffar, Andreea Varga, Emrullah Yilmaz, Yuta Ikawa, Lisa H Shiue, Yi Liu, Matthew W Hruska, Henry Zhao, Akihiro Tokunaga, Solmaz Sahebjam

Faculty, Staff and Student Publications

Background: Indoleamine 2,3-dioxygenase 1 (IDO1) is a heme-containing enzyme that degrades tryptophan (Trp) to kynurenine (Kyn), which suppresses effector T cells and reduces antitumor activity. KHK2455 is a long-acting selective IDO1 inhibitor that blocks the heme component of the IDO holoenzyme. Mogamulizumab is a humanized immunoglobulin G1 monoclonal antibody targeting CCR4. KHK2455 + mogamulizumab demonstrated enhanced antitumor activity in preclinical studies, which led to a first-in-human, two-part, multicenter, open-label, phase 1, dose-escalation, cohort-expansion trial (ClinicalTrials.gov identifier NCT02867007) evaluating the safety/tolerability, pharmacokinetics, and IDO1 activity of KHK2455 alone and in combination with mogamulizumab in patients with treatment-refractory advanced solid tumors. …


The Landscape Of Malignant Transition: Unraveling Cancer Cell-Of-Origin And Heterogeneous Tissue Microenvironment, Ruihan Luo, Jiajia Liu, Tiangang Wang, Weiling Zhao, Yanfei Wang, Jianguo Wen, Hongyu Wang, Shanli Ding, Xiaobo Zhou Jul 2025

The Landscape Of Malignant Transition: Unraveling Cancer Cell-Of-Origin And Heterogeneous Tissue Microenvironment, Ruihan Luo, Jiajia Liu, Tiangang Wang, Weiling Zhao, Yanfei Wang, Jianguo Wen, Hongyu Wang, Shanli Ding, Xiaobo Zhou

Faculty, Staff and Student Publications

Understanding disease progression and sophisticated tumor ecosystems is imperative for investigating tumorigenesis mechanisms and developing novel prevention strategies. Here, we dissected heterogeneous microenvironments during malignant transitions by leveraging data from 1396 samples spanning 13 major tissues. Within transitional stem-like subpopulations highly enriched in precancers and cancers, we identified 30 recurring cellular states strongly linked to malignancy, including hypoxia and epithelial senescence, revealing a high degree of plasticity in epithelial stem cells. By characterizing dynamics in stem-cell crosstalk with the microenvironment along the pseudotime axis, we found differential roles of ANXA1 at different stages of tumor development. In precancerous stages, reduced …