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Inorganic Nanoparticle And Nanoplastic Transformations And The Impact On Biouptake By Freshwater Algal Cells Using Single Cell And Single Particle Inductively Coupled Plasma Mass Spectrometry, Elizabeth Carey Bair Jul 2025

Inorganic Nanoparticle And Nanoplastic Transformations And The Impact On Biouptake By Freshwater Algal Cells Using Single Cell And Single Particle Inductively Coupled Plasma Mass Spectrometry, Elizabeth Carey Bair

Theses and Dissertations

The ubiquitous presence of nanoparticles (NPs) and nanoplastics (NPPs) and their effects on environmental and human health is a significant concern. They are used in every aspect of our lives, and while they offer many benefits, there are concerns about their impacts on ecosystems and human health. The primary aim of this dissertation is to quantify NP and NPP transformations in the presence of algae and determine how those transformations influence bioavailability. The methodology involves two complementary analytical techniques: single particle (SP) and single cell (SC) inductively coupled plasma mass spectrometry (ICP-MS). These techniques are tested and applied to two …


Birth Of Inspiration: York County, South Carolina, The Setting That Inspired The Clansman, Zachary Alan Lemhouse Jul 2025

Birth Of Inspiration: York County, South Carolina, The Setting That Inspired The Clansman, Zachary Alan Lemhouse

Theses and Dissertations

In 1905, Thomas Dixon, Jr., published his controversial novel The Clansman. Monopolizing on racist sentiments held by white southerners, Dixon’s narrative contributed significantly to the perception of the Lost Cause myth and defense of white supremacy in America. The novel, and its subsequent adaptations as a play and the film Birth of a Nation, was inspired by actual events that occurred in Dixon’s ancestral home of York County, South Carolina. Located in the northernmost region of South Carolina’s Piedmont, York County played host to a struggle for civil rights during the Reconstruction Era that garnered national and international …


The Intersection Of Rurality And Wellness: A Multi-Manuscript Investigation Into Rural Well-Being, Lucas Perez Jul 2025

The Intersection Of Rurality And Wellness: A Multi-Manuscript Investigation Into Rural Well-Being, Lucas Perez

Theses and Dissertations

Rural communities face unique mental health and wellness challenges, including geographic isolation, provider shortages, and stigma surrounding help-seeking. This dissertation explores rural wellness through three interrelated studies, utilizing both qualitative and quantitative methods to examine disparities, perceptions of rurality, and demographic influences on well-being. The first study utilized the Five Factor Wellness Inventory (5F-WEL) to compare wellness scores between rural and non-rural individuals. The second study employed Interpretative Phenomenological Analysis (IPA) to explore rural definitions of wellness, as well as barriers and strengths related to mental health. The third study examined how perceptions of rurality and demographic factors predict wellness …


William Hogarth's Portraiture: A Vehicle For Social Commentary, Kaitlyn Elizabeth Hoff Jul 2025

William Hogarth's Portraiture: A Vehicle For Social Commentary, Kaitlyn Elizabeth Hoff

Theses and Dissertations

William Hogarth is often celebrated for the critiques of eighteenth-century England seen throughout his widely reproduced satirical print series and paintings, however his contributions to portraiture offer a compelling extension of his artistic vision and techniques. This research aims to explore Hogarth’s use of portraiture as a vehicle for social commentary and moral messaging, revealing broader themes of morality, nationalism, and identity among all of his works, comparing this approach to that of both his contemporaries and his own prints.

In examining Hogarth’s portraits alongside other formal portraiture, the socio-political landscape of the time, and existing scholarship, methods such as …


Aesthetic Judgment: Considering A Contemporary Standard Of Taste, Lydia Margaret Lee Jul 2025

Aesthetic Judgment: Considering A Contemporary Standard Of Taste, Lydia Margaret Lee

Theses and Dissertations

Originally published in 1757 as part of his Four Dissertations essay collection, David Hume’s essay, “Of the Standard of Taste,” occupies a prominent place in Enlightenment aesthetic studies. Due to an oversaturation of print materials being produced, eighteenth century society was concerned with evaluating and ranking the massive quantities of art being produced. Philosophers such as David Hume attempted to define criteria for determining a standard of taste, aiming to hierarchically rank works of art based on aesthetic experience. For centuries, critics such as Timothy Costelloe, Noel Carroll, David Marshall, Jonathan Friday, James Shelley, and many others have engaged in …


Ideologies Of Language, Race, And Time In U.S. Political Discourses, Paige Pinkston Jul 2025

Ideologies Of Language, Race, And Time In U.S. Political Discourses, Paige Pinkston

Theses and Dissertations

This dissertation follows how public discourses that emerged during the 2020- 2022 “Critical Race Theory Panic” played out in different contexts and at different scales in the United States, from conservative national media to South Carolina legislative action. While political discourse has become increasingly nationalized (Berry & Sobieraj, 2014), new legislation has largely taken place at the state level (Johnson, 2022). Drawing on over two years of fieldwork and methods of discourse analysis, I thus examine how nationally circulating discourses about race and racism were taken up by South Carolinians to create partisan alignments and distinctions as well as to …


Help-Seeking, Motivation, And Partner Interactions In Couples Affected By Tramatic Brain Injury, Violet Hodge Jul 2025

Help-Seeking, Motivation, And Partner Interactions In Couples Affected By Tramatic Brain Injury, Violet Hodge

Theses and Dissertations

Traumatic brain injury (TBI) affects individuals and their romantic relationships, creating barriers to help-seeking and impacting relational health. Despite evidence supporting the benefits of couples counseling and relationship education, stigma and motivational factors influence engagement in these services. This dissertation examines the interdependent processes of help-seeking, motivation, and relationship satisfaction in couples where one partner has experienced a TBI. Using the Actor-Partner Interdependence Model (APIM), two studies explore (1) the role of self-stigma in help-seeking and motivation for completing a relationship education program, and (2) the influence of self-stigma for help-seeking on motivation in couples services, particularly in the context …


Reluctant Transitions: Place And Post-Extraction Politics In Southeastern Ohio, Jenna Lynn Haver Jul 2025

Reluctant Transitions: Place And Post-Extraction Politics In Southeastern Ohio, Jenna Lynn Haver

Theses and Dissertations

Based on a summer of ethnographic research in a subsection of Appalachian Ohio colloquially referred to as “The Valley,” this research challenges three narratives of this place that formulate a harmful Appalachian imaginary. The first narrative of industrycontrolled coal heritage is complicated by the way local people negotiate control over their own stories of coal and its existence outside of industry domain. The second narrative characterizes this as a space of extraction which is in tension with different social relations to varying types of energy – especially the discontinuity of the coal to fracking shift. The third narrative centers of …


“Cruelty, Bloodshed, And Degradation From The Inauspicious Conjunction Of Stars”: “Magic” In The 1857-58 Rebellion In India, Summer Bordon Jul 2025

“Cruelty, Bloodshed, And Degradation From The Inauspicious Conjunction Of Stars”: “Magic” In The 1857-58 Rebellion In India, Summer Bordon

Theses and Dissertations

During the 1857-58 rebellion in India, British soldiers and civilians saw ample evidence of Indian belief in “magic”. Prophecies about the end of British rule were implicated in inciting rebellion. When a solar eclipse occurred during the British army’s campaign to regain control of Delhi, victory was attributed partially to Indian superstition. Much of the historiography of the 1857-58 rebellion has uncritically accepted British sources’ conceptions of Indian “magic”, dismissing it as superstitious, politically hindering, and divorced from material reality. Yet, British understandings of magic cannot be taken at face value. Instead, they must be located within broader colonial narratives …


Queer Inclusion In Libba Bray's Beauty Queens: The Case For Lgbtq Ya Literature, Kayla Michelle Crumbley Jul 2025

Queer Inclusion In Libba Bray's Beauty Queens: The Case For Lgbtq Ya Literature, Kayla Michelle Crumbley

Theses and Dissertations

This thesis is a time sensitive case study on the nature of Libba Bray's novel Beauty Queensand it's placement as both a metacognitive novel and discourse in the nature of queer acceptance in the publishing and media landscape of the 2010s and 2020s. This includes focusing on contextualizing the book in the changing landscape of queer acceptance and visibility in the media over the last 20 years through the lens of the inclusion in YA and how that manifest in the 2010 and 2020s book bans on LGBTQ YA fiction. The novel highlights the wider need for LGBTQ YA …


Emotional Landscapes: St. Teresa Of Avila And The Spiritual Journey, Jillian Louise Breeden Jul 2025

Emotional Landscapes: St. Teresa Of Avila And The Spiritual Journey, Jillian Louise Breeden

Theses and Dissertations

This paper examines the writings of St. Teresa of Avila (1515-1582) through the methodological lens of the history of emotions, arguing that her mystical accounts represent a crucial yet understudied contribution to our understanding of early modern emotional frameworks. Through close textual analysis of Teresa's major works, this study demonstrates how her detailed articulations of spiritual ecstasy, divine love, and religious melancholy offer unique insights into both the religious and secular emotional landscapes of Counter-Reformation Spain. Teresa's innovative emotional vocabulary, which combined traditional Catholic devotional language with embodied metaphors and spatial conceptualizations, allowed her to navigate the complex ecclesiastical politics …


The Penn Center’S Impact On Rural Health Through Midwife Programming In 20Th Century South Carolina, Kathryn Addison Greenberg Jul 2025

The Penn Center’S Impact On Rural Health Through Midwife Programming In 20Th Century South Carolina, Kathryn Addison Greenberg

Theses and Dissertations

The Penn School of the Sea Islands provided an education to thousands of rural, Black South Carolinians over the twentieth century. Northern missionaries including the founders of the Penn School, Laura M. Towne and Ellen Murray, taught and provided healthcare to the residents of the Port Royal Experiment through the Civil War and into Reconstruction. With the arrival of Rossa Cooley and Grace House, the Penn School put emphasis on auxiliary programing including midwifery training institutes held in conjunction with Dr. Hilla Sheriff and the South Carolina Department of Public Health’s Division for Maternal and Child Health. With the goal …


Exploring The Holistic Wellness Of Black Women Counselors, Shanta A. Jerideau Jul 2025

Exploring The Holistic Wellness Of Black Women Counselors, Shanta A. Jerideau

Theses and Dissertations

Counselor wellness is crucial for clinician longevity and ethical practice. However, there is limited literature on the holistic wellness of Black women counselors. This manuscript probes into the lived experiences of Black women counselors, particularly in relation to the sociopolitical climate and racial injustices in the United States. Utilizing Consensual Qualitative Research, we examine the experiences of 15 Black women counselors working in counselor education, private practice, and community agencies within the Southeast Region of the United States. We anticipate this approach will enhance counselor education literature and foster increased peer support.


Essential Characteristics And Perceived Needs Of Teachers And School Leaders Of Steam-Focused Elementary Schools: An Exploratory Study, Christopher Abbaleo Jul 2025

Essential Characteristics And Perceived Needs Of Teachers And School Leaders Of Steam-Focused Elementary Schools: An Exploratory Study, Christopher Abbaleo

Theses and Dissertations

While STEAM (science, technology, engineering, arts, and mathematics) education has traditionally been emphasized at the high school level, there is growing recognition of its importance in elementary education. This exploratory, action research multiple-case study identified the essential characteristics of two STEAM-focused elementary schools and how they are operationalized as well as the perceived needs of teachers and school leaders working within the schools. Within-case analyses and a cross-case synthesis revealed both common and distinct STEAM-focused curricular approaches, along with other commonalities such as enriching co-curricular offerings, connections to STEAM careers, professional development, teacher collaboration, visionary leadership, and networking with external …


Characterizing The Relationships Between Cranial Geometry, Brain Morphometry, And Brain Mechanical Properties Using Mr Imaging And Elastography, Jessica Restivo Jul 2025

Characterizing The Relationships Between Cranial Geometry, Brain Morphometry, And Brain Mechanical Properties Using Mr Imaging And Elastography, Jessica Restivo

Theses and Dissertations

Traumatic brain injury (TBI) is a global health concern, with over 69 million cases annually. TBI risk depends on subject-specific neuroanatomical variation, yet research often only considers generic finite element (FE) models, based on the geometry and material composition of a 50th percentile male head. Although highly accurate, subject-specific models require expensive magnetic resonance (MR) imaging, elastography, and time-consuming computational resources. There is a need to create subject-specific TBI models that account for subject-specific variations, without neuroimaging. This study aims to create mathematical models to predict brain morphometry (dimensions, volume) [Objective 1] and mechanical properties (shear stiffness, damping ratio, octahedral …


"We Have Such Fantastic People Working Here": Using Action Research To Address Community College Burnout, Christine Pipitone Jul 2025

"We Have Such Fantastic People Working Here": Using Action Research To Address Community College Burnout, Christine Pipitone

Theses and Dissertations

This mixed-methods action research dissertation explores faculty burnout at a New Jersey community college to propose actionable, faculty-led solutions through a collaborative approach. Grounded in a theoretical framework that integrates theories of action, critical theory, and job demands–resources theory, the study included three phases that followed an explanatory sequential design. In the first phase, quantitative and qualitative data obtained through an anonymous questionnaire provided baseline information about the dimensions of burnout participants experienced. The data informed the second phase, which consisted of semi-structured focus group interviews. In the third phase, an action research team worked together to make recommendations based …


Investigating Mechanisms And Day-Level Factors That Influence Children’S 24-Hour Movement Behaviors, Hannah Parker Jul 2025

Investigating Mechanisms And Day-Level Factors That Influence Children’S 24-Hour Movement Behaviors, Hannah Parker

Theses and Dissertations

Twenty-four hour movement behaviors (i.e., physical activity (PA), screen time (ST), and sleep) are associated with health outcomes, chronic disease (obesity, type 2 diabetes), and mortality. Most literature evaluating children’s 24-hour movement behaviors has focused on static person-level demographic information such as age or biological sex. Relatively less work has examined the variable factors that change day to day, such as environment or context. The Structured Days Hypothesis (SDH) suggests that when children are in structured environments, they have healthier movement behaviors compared to less structured environments where children have more discretionary time to engage in obesogenic behaviors. Besides school/childcare, …


Students’ Experiences Using Peer Review To Affect Writing Self-Efficacy And Writing Performance In An Undergraduate Mass Communications Writing Course, Nina Morrison Brook Jul 2025

Students’ Experiences Using Peer Review To Affect Writing Self-Efficacy And Writing Performance In An Undergraduate Mass Communications Writing Course, Nina Morrison Brook

Theses and Dissertations

The purpose of this action research was to examine the impact of peer review on writing self-efficacy and writing performance in an undergraduate online writing for mass communications course. The study focused on two research questions: (1) How and to what extent does structured peer review affect undergraduate students’ writing self-efficacy in an online writing for mass communications course in a large public Southeastern university? and (2) How and to what extent does structured peer review affect undergraduate students’ writing performance in an online writing for mass communications course in a large public Southeastern university? This research used peer review …


Do-Reflect-Apply In The Showring, Hannah Majewski Jul 2025

Do-Reflect-Apply In The Showring, Hannah Majewski

UNH Cooperative Extension

4-H uses the “Experiential Learning Model” as a way to create high quality youth programs. This model, commonly known as “Do-Reflect-Apply” focuses not only on the particular 4-H experience, but also how youth are interpreting their learning, and if they can apply it to real world scenarios. In the context of the showring, the goal is for youth to dive into their animal projects and learn about industry standards with agriculture, while also developing into capable young adults.


Focus On Wildlife Swifts & Swallows Of Nh, Haley Andreozzi, Pam Hunt Jul 2025

Focus On Wildlife Swifts & Swallows Of Nh, Haley Andreozzi, Pam Hunt

UNH Cooperative Extension

No abstract provided.


Bitter Rot [Fact Sheet], Liza Degenring Jul 2025

Bitter Rot [Fact Sheet], Liza Degenring

UNH Cooperative Extension

No abstract provided.


Personal Protective Equipment (Ppe) For Pesticide Use, Rachel Maccini Jul 2025

Personal Protective Equipment (Ppe) For Pesticide Use, Rachel Maccini

UNH Cooperative Extension

No abstract provided.


Quantifying Marine Carbon Dioxide Removal Via Alkalinity Enhancement Across Circulation Regimes Using Ecco-Darwin And 1d Models, Kay Suselj, Dustin Carroll, Daniel Whitt, Bridget Samuels, Dimitris Menemenlis, Hong Zhang, Nate Beatty, Anna Savage Jul 2025

Quantifying Marine Carbon Dioxide Removal Via Alkalinity Enhancement Across Circulation Regimes Using Ecco-Darwin And 1d Models, Kay Suselj, Dustin Carroll, Daniel Whitt, Bridget Samuels, Dimitris Menemenlis, Hong Zhang, Nate Beatty, Anna Savage

Faculty Research, Scholarly, and Creative Activity

Ocean Alkalinity Enhancement (OAE) is emerging as a viable method for removing anthropogenic (Formula presented.) emissions from the atmosphere to mitigate climate change. To achieve substantial carbon reductions, OAE would need to be deployed at scale across the global ocean. Hence, there is a need to quantify how the efficiency of OAE varies globally across a range of space-time scales in preparation for field deployments. Here we develop a marine carbon dioxide removal (mCDR) efficiency evaluation framework based on the data-assimilative ECCO-Darwin ocean biogeochemistry model, which separates and quantifies two key factors over seasonal to multi-annual timescales: (a) mCDR potential, …


Conservation Management Effects On Soil And Agronomic Properties In A Furrow-Irrigated Corn System In East-Central Arkansas, Jeferson P. Pimentel, Christopher G. Henry, Kris R. Brye, Benjamin R. Runkle, Amanda J. Ashworth, Edgar Mersiovsky, Kevin C. Thompson Jul 2025

Conservation Management Effects On Soil And Agronomic Properties In A Furrow-Irrigated Corn System In East-Central Arkansas, Jeferson P. Pimentel, Christopher G. Henry, Kris R. Brye, Benjamin R. Runkle, Amanda J. Ashworth, Edgar Mersiovsky, Kevin C. Thompson

Biological and Agricultural Engineering Faculty Publications and Presentations

Cover crops can improve soil physical properties and help to sustain agricultural crop yields. A 6-year study conducted from 2017 to 2022 examined the effects of conservation soil management practices in a furrow-irrigated continuous corn (Zea mays L.) system on a silt-loam soil (Typic Albaqualf) in the Lower Mississippi River Delta region of eastern Arkansas. This study compared the effects of conventional tillage (CT), no-tillage (NT), and no-tillage with cover crops (CC) in selected soil physical and chemical properties (i.e., soil bulk density (D b), porosity (& fnof;t), field capacity (Theta FC), Permanent wilting point (Theta PWP), Plant available water …


Exhibitions And Events, Summer 2025, University Galleries Jul 2025

Exhibitions And Events, Summer 2025, University Galleries

Exhibition and Event Schedules - University Galleries

Listing of exhibitions, events, and lectures held at the University Galleries at Illinois State University.


A Recipe For Disaster - Sodium Bicarbonate Overdose, Adeola A Kosoko, Amara Ogoke, Kyle Vogt Jul 2025

A Recipe For Disaster - Sodium Bicarbonate Overdose, Adeola A Kosoko, Amara Ogoke, Kyle Vogt

Faculty, Staff and Student Publications

Audience: Emergency medicine residents post-graduate years 1-4.

Introduction: Sodium bicarbonate is a compound found commonplace in many households and in many products. It lends itself to countless everyday uses including cooking and cleaning. Physicians prescribe sodium bicarbonate regularly both on- and off-label regularly for various ailments.1 Due to the ubiquitous way both emergency physicians and the general public use and are exposed to sodium bicarbonate, we wanted to prepare learners to identify and appropriately manage sodium bicarbonate toxicity.Obtaining a thorough history not just of medications prescribed but of significant ingestions or infusions is critical in diagnosing this toxicity. Furthermore, acute …


Efficacy And Safety Of Mechanical Thrombectomy In Distal Medium Middle Cerebral Artery Occlusion Ischemic Stroke Patients On Low-Dose Aspirin, Hamza Adel Salim, Vivek Yedavalli, Fathi Milhem, Basel Musmar, Nimer Adeeb, Motaz Daraghma, Kareem El Naamani, Nils Henninger, Sri Hari Sundararajan, Anna Luisa Kühn, Jane Khalife, Sherief Ghozy, Luca Scarcia, Benjamin Yq Tan, Robert W Regenhardt, Jeremy J Heit, Nicole M Cancelliere, Joshua D Bernstock, Aymeric Rouchaud, Jens Fiehler, Sunil Sheth, Ajit S Puri, Christian Dyzmann, Marco Colasurdo, Leonardo Renieri, João Pedro Filipe, Pablo Harker, Răzvan Alexandru Radu, Mohamad Abdalkader, Piers Klein, Thomas R Marotta, Julian Spears, Takahiro Ota, Ashkan Mowla, Pascal Jabbour, Arundhati Biswas, Frédéric Clarençon, James E Siegler, Thanh N Nguyen, Ricardo Varela, Amanda Baker, Muhammed Amir Essibayi, David Altschul, Nestor R Gonzalez, Markus A Möhlenbruch, Vincent Costalat, Benjamin Gory, Christian Paul Stracke, Constantin Hecker, Hamza Shaikh, Christoph J Griessenauer, David S Liebeskind, Alessandro Pedicelli, Andrea M Alexandre, Illario Tancredi, Tobias D Faizy, Erwah Kalsoum, Max Wintermark, Boris Lubicz, Aman B Patel, Vitor Mendes Pereira, Adrien Guenego, Adam A Dmytriw Jul 2025

Efficacy And Safety Of Mechanical Thrombectomy In Distal Medium Middle Cerebral Artery Occlusion Ischemic Stroke Patients On Low-Dose Aspirin, Hamza Adel Salim, Vivek Yedavalli, Fathi Milhem, Basel Musmar, Nimer Adeeb, Motaz Daraghma, Kareem El Naamani, Nils Henninger, Sri Hari Sundararajan, Anna Luisa Kühn, Jane Khalife, Sherief Ghozy, Luca Scarcia, Benjamin Yq Tan, Robert W Regenhardt, Jeremy J Heit, Nicole M Cancelliere, Joshua D Bernstock, Aymeric Rouchaud, Jens Fiehler, Sunil Sheth, Ajit S Puri, Christian Dyzmann, Marco Colasurdo, Leonardo Renieri, João Pedro Filipe, Pablo Harker, Răzvan Alexandru Radu, Mohamad Abdalkader, Piers Klein, Thomas R Marotta, Julian Spears, Takahiro Ota, Ashkan Mowla, Pascal Jabbour, Arundhati Biswas, Frédéric Clarençon, James E Siegler, Thanh N Nguyen, Ricardo Varela, Amanda Baker, Muhammed Amir Essibayi, David Altschul, Nestor R Gonzalez, Markus A Möhlenbruch, Vincent Costalat, Benjamin Gory, Christian Paul Stracke, Constantin Hecker, Hamza Shaikh, Christoph J Griessenauer, David S Liebeskind, Alessandro Pedicelli, Andrea M Alexandre, Illario Tancredi, Tobias D Faizy, Erwah Kalsoum, Max Wintermark, Boris Lubicz, Aman B Patel, Vitor Mendes Pereira, Adrien Guenego, Adam A Dmytriw

Faculty, Staff and Student Publications

Background: Acute ischemic stroke (AIS) from distal medium vessel occlusion (DMVO) presents unique treatment challenges. Mechanical thrombectomy (MT) is emerging as a viable option for these patients, yet the role of pre-stroke aspirin treatment is unclear. This study evaluates the impact of pre-stroke low-dose aspirin on outcomes in DMVO patients undergoing MT.

Methods: We conducted a multinational, multicenter, propensity score-weighted analysis within the Multicenter Analysis of primary Distal medium vessel occlusions: effect of Mechanical Thrombectomy (MAD-MT) registry. Patients with AIS due to DMVO, treated with MT, were included. We compared outcomes between patients on pre-stroke low-dose aspirin (75-100 mg) and …


Psy News, Summer 2025, Illinois State University, Department Of Psychology Jul 2025

Psy News, Summer 2025, Illinois State University, Department Of Psychology

Psych News

Newsletter of the Department of Psychology


Interconnections Of Insulin/Igf-1 Signaling And Autophagy Abnormalities In Alzheimer’S Disease, Wang Liao, Jinfeng Xuan, Woo-In Ryu, Mariana K Bormann, Yoon Lee, Haley Dion, Elizabeth Evangelista, Ruiyi Li, Lucas Trambaiolli, Jun Liu, Arthur J Siegel, Brent P Forester, Bruce M Cohen, Kai-Christian Sonntag Jul 2025

Interconnections Of Insulin/Igf-1 Signaling And Autophagy Abnormalities In Alzheimer’S Disease, Wang Liao, Jinfeng Xuan, Woo-In Ryu, Mariana K Bormann, Yoon Lee, Haley Dion, Elizabeth Evangelista, Ruiyi Li, Lucas Trambaiolli, Jun Liu, Arthur J Siegel, Brent P Forester, Bruce M Cohen, Kai-Christian Sonntag

Faculty, Staff and Student Publications

Introduction: Impaired insulin (INS) and insulin-like growth factor 1 (IGF-1) signaling are features of both brain aging and late-onset Alzheimer's disease (LOAD). However, their exact underlying mechanisms and cause-and-effect linkages, including the downstream regulation of endocytosis and autophagy, are still not well understood.

Methods: We investigated INS/IGF-1 signaling and its connection with endocytic and autophagic processes in fibroblasts from LOAD patients and healthy young or old control individuals.

Results: Compared to control old-age cells, protein levels in the INS/IGF-1 signaling cascade were elevated in LOAD cells, but activation of AKT was reduced. The activation of the INS/IGF-1/AKT/FOXO1 or mTOR axes …


Arterial Anastomosis To Injured Vessels: Outcomes In Lower Extremity Trauma Reconstruction, Ellen Wang, Jessica R Nye, Imran Rizvi, Kylie R Swiekatowski, Bora Kahramangil, Paul Won, Noa G Kopplin, Stephen F Parlamas, Jeffrey G Trost, Mohin A Bhadkamkar Jul 2025

Arterial Anastomosis To Injured Vessels: Outcomes In Lower Extremity Trauma Reconstruction, Ellen Wang, Jessica R Nye, Imran Rizvi, Kylie R Swiekatowski, Bora Kahramangil, Paul Won, Noa G Kopplin, Stephen F Parlamas, Jeffrey G Trost, Mohin A Bhadkamkar

Faculty, Staff and Student Publications

Background: Although traditional teaching advocates that microsurgical anastomoses should be performed to uninjured vessels outside the zone of injury (ZOI), there is no defined way to assess the extent of the ZOI, and uninjured vessels may not be available. To evaluate the complications ascribed to the ZOI and injured vessels, outcomes between arterial anastomoses fashioned from within the ZOI versus noninjured recipient vessels were compared.

Methods: A retrospective review was conducted of adult patients who required lower extremity free flap (FF) reconstruction from 2016 to 2024. Injury to the recipient artery (transection, avulsion, or thrombosis) was determined by intraoperative assessment …