Digital Commons Network^™

Role Of Lipoprotein(A) In Atherosclerotic Cardiovascular Disease In South Asian Individuals, Darshan Patel, Marlys L Koschinsky, Anandita Agarwala, Pradeep Natarajan, Harpreet S Bhatia, Anurag Mehta, Jaideep Patel, Matthew Peters, Shreya Pandya, Usman Sagheer, Raman Puri, Salim S Virani, Dinesh K Kalra

Faculty, Staff and Students Publications

South Asian individuals (SA), representing approximately one quarter of the global population, experience a disproportionately high burden of cardiovascular disease. Some of this increased susceptibility is accounted for by traditional risk factors such as diabetes, hypertension, carbohydrate-rich diets, and rising rates of obesity and metabolic syndrome. However, other previously underappreciated risk factors may also play a crucial role. These include environmental pollution, genetic factors, and Lp(a) (lipoprotein(a)). Various epidemiological and genetic studies support the role of Lp(a) as a causal and independent risk factor for atherosclerotic cardiovascular disease. SA have a higher prevalence of elevated Lp(a) levels (25% have levels …

X-Linked Hypophosphatemia Management In Adults: An International Working Group Clinical Practice Guideline., Aliya A. Khan, Dalal S. Ali, Natasha M. Appelman-Dijkstra, Thomas O. Carpenter, Catherine Chaussain, Erik A. Imel, Suzanne M. Jan De Beur, Pablo Florenzano, Hajar Abu Alrob, Rana Aldabagh, R Todd Alexander, Farah Alsarraf, Signe Sparre Beck-Nielsen, Martin Biosse-Duplan, Martine Cohen-Solal, Rachel K. Crowley, Karel Dandurand, Guido Filler, Lisa Friedlander, Seiji Fukumoto, Claudia Gagnon, Paul Goodyer, Corinna Grasemann, Chelsey Grimbly, Salma Hussein, Muhammad K Javaid, Sarah Khan, Aneal Khan, Anna Lehman, Willem F. Lems, E Michael Lewiecki, Ciara Mcdonnell, Reza D. Mirza, Emmett Morgante, Archibald Morrison, Anthony A. Portale, Yumie Rhee, Eric T. Rush, Heide Siggelkow, Sotirios Tetradis, Laura Tosi, Leanne M. Ward, Gordon Guyatt, Maria Luisa Brandi

Manuscripts, Articles, Book Chapters and Other Papers

PURPOSE: An international working group (IWG) consisting of experts in X-linked hypophosphatemia (XLH) developed global guidelines providing a comprehensive, evidence-based approach to XLH diagnosis, management, and monitoring.

METHODS: The IWG, consisting of 43 members as well as methodologists and a patient partner, conducted 2 systematic reviews (SRs) and narrative reviews to address key areas. The SRs addressed the impact of burosumab compared to conventional therapy (phosphate and active vitamin D) or no therapy on patient-important outcomes in adults. They also evaluated conventional therapy compared to no therapy. GRADE methodology was applied to evaluate the certainty of evidence. Non-GRADED recommendations were …

Role Of Nurses And Allied Health Professionals In Hepatology And The Challenges Faced When Navigating A Career Pathway, Lynsey Spillman, Dianne Backhouse, Leah Cox, Katie Ballesteros, Katie Ramos, Felicity Williams

School of Health Professions

Hepatology specialist nurses and allied health professionals (AHPs), including dietitians and physiotherapists, are essential members of the multidisciplinary team, delivering person-centred care from prevention through to advanced disease. Their contributions support lifestyle intervention, symptom management and care coordination, improving patient outcomes and service efficiency. Despite this, roles remain underfunded, inconsistently embedded and often overlooked in workforce planning. This article outlines the impact and challenges facing hepatology nurses and AHPs, drawing on UK service examples that demonstrate improved quality of life, reduced admissions, recompensation and cost savings. Barriers include limited access to structured training, protected time and clearly defined career pathways. …

Identity Development, Attraction, And Behavior Of Heterosexual-Identified Men Who Have Sex With Men: A Scoping Review, Andrew D. Eaton, Travis R. Scheadler, Melanie Mcdonald, Oliver Beer, Lauren B. Mcinroy, Erin Beckwell, Adam Busch, Cara Bradley, Paul A. Shuper

School of Health Professions

Introduction: Heterosexual-identified men who have sex with men (H-MSM) experience sexual identity and behavior discordance. H-MSM may comprise 0.5–3.5% of adult heterosexual men. Understanding and accepting H-MSM as they self-identify may be necessary to implement effective public health and psychosocial interventions. This scoping review synthesizes research on H-MSM’s identity development, attraction, and behavior. Methods: Thirteen databases were searched and, using Covidence software, two independent reviewers screened 3617 titles and abstracts and 269 full texts to arrive at 124 articles meeting entry criteria. Ten independent reviewers then conducted thematic content analysis. Results:H-MSM either expressed sexual identity uncertainty or justified maintaining heterosexual …

Distribution Of Alkylamines In Surface Waters Around The Antarctic Peninsula And Weddell Sea, Arianna Rocchi, Mark F. Fitzsimons, Preston Chebai Akenga, Ana Sotomayor, Elisabet L. Sà, Queralt Güell-Bujons, Magda Vila, Yaiza M. Castillo, Manuel Dall'osto, Dolors Vaqué, Charel Wohl, Rafel Simó, Elisa Berdalet

School of Geography, Earth and Environmental Sciences

Alkylamines, volatile organic nitrogen compounds with low molecular weight, are present in the surface ocean and participate in the marine biogeochemical nitrogen cycle, atmospheric chemistry and cloud formation. Alkylamines have been detected in polar regions, suggesting that these areas constitute emission hotspots of these compounds. However, knowledge of the sea surface distribution patterns and factors modulating alkylamines remain limited due to their high reactivity and low concentrations, which hamper accurate measurements. We investigated the presence and distribution of alkylamines in seawaters around the Antarctic Peninsula and the northern Weddell Sea during the late austral summer and explored their potential links …

Heart Failure With Reduced Ejection Fraction Polypill Implementation Strategy In Sri Lanka: Design And Protocol Of A Pilot Type I Hybrid Randomised Clinical Trial, Anubha Agarwal, Mansi Agarwal, Charles W. Goss, Adam Hively, Mark D. Huffman, Et Al.

2020-Current year OA Pubs

No abstract provided.

An Extended Robust Optimisation Approach For Sustainable And Resilient Supply Chain Network Design: A Case Of Perishable Products, Seyed Ashkan Hosseini Shekarabi, Reza Kiani Mavi, Flavio Romero Macau

Research outputs 2022 to 2026

Disruptions and uncertainties pose considerable challenges in supply chain (SC) operations, requiring robust, strategic approaches. This study addresses financial resource allocation between supply chain network (SCN) design and external market investments, explicitly considering budget allocation and sales representative selection for perishable products. We propose a novel axis-shift robust (AxShR) method combined with an enhanced p-robust optimisation framework to manage multiple complex uncertainties. The model introduces a new resilience strategy allowing retailers to transfer products within the SCN, and apply artificial intelligence (AI) via a neural network to predict disruptions by evaluating risk indicators such as supplier location risk, raw material …

Integrated Genomic Analysis Of Nf1-Associated Peripheral Nerve Sheath Tumors: An Updated Biorepository Dataset, Jineta Banerjee, Yang Lyu, Kuangying Yang, Angela C Hirbe, Et Al.

2020-Current year OA Pubs

Neurofibromatosis type 1 (NF1) is an inherited neurocutaneous condition that predisposes to the development of peripheral nerve sheath tumors (PNST) including cutaneous neurofibromas (CNF), plexiform neurofibromas (PNF), atypical neurofibromatous neoplasms of uncertain biologic potential (ANNUBP), and malignant peripheral nerve sheath tumors (MPNST). The Johns Hopkins NF1 biospecimen repository promotes the successful advancement of therapeutic developments for NF1-associated PNST through acquisition and genomic analysis of human tumor specimens. RNA sequencing (RNAseq) and whole exome sequencing (WES) data were generated from 73 and 114 primary human tumor samples, respectively. These pre-processed data, standardized for immediate computational analysis, are accessible through the NF …

Targeting Triple-Negative Breast Cancer With Momordicine-I For Therapeutic Gain In Preclinical Models, Kousik Kesh, Ellen T Tran, Ruchi A Patel, Cynthia X Ma, Ratna B Ray

2020-Current year OA Pubs

No abstract provided.

H2-Rich Biogas Production From Fixed Bed Wheat Straw Pyrolysis And The Potential Of Produced Biochar As H2 Storage Material, Tawanda Matamba, Hussein Rasool Abid, Alireza Keshavarz, Stefan Iglauer

Research outputs 2022 to 2026

H2 is a clean energy source, and is targeted as one of the ways to transition from fossil fuels. However, there are drawbacks in production and storage of hydrogen. To cover the supply, we need H2 from many resources and because of its low density we need materials that can store bulky quantities of H2. Here we investigated the potential of a renewable source (waste wheat straw) to produce and store H2 through pyrolysis and adsorption. The impact of pressure and temperature (500–900 °C, and 1.01–30 bar range) on the selectivity of H2 rich gas production was systematically investigated; and …

The Ethics Of Mass Communication

Communication Research Trends

Recent years have seen an unprecedented uncertainty and debate over the ethics of mass media. James Thomson, curator of Nieman fellowships for journalists at Harvard University, detects in experienced journalists increasing doubt - even cynicism - regarding the morality of many accepted media practices. John Birt, associated with ITV in London, notes much more questioning of the morality of television programming in Britain.

One might expect the churches to help in clarifying issues of media ethics. The Catholic Church, for example, has a strong tradition of philosophical analysis of ethical problems. Yet, surprisingly, except in Spain, one finds little involvement …

The New International Information Order

Communication Research Trends

In the Nineteenth Century the lines of international communication tended to follow the paths of the NorthAtlantic empires. The cartel of European and American news agencies divided up the world according to the political and economic spheres of influence of the day. Reuters in London took the British Empire; Havas in Paris, the Latin world and French-speaking dependencies; Wolff in Berlin, the Scandinavian countries and Eastern Europe; the American Associated Press and United Press followed U.S. expansion. Just as roads held together the Roman Empire, so transoceanic cables, radio frequencies and satellites have been the lifelines of modern empires.

After …

Bias In The News

Communication Research Trends

Over the past 100 to 150 years, print and now broadcast news have built an image as the vital support of democratic public decision-making. Journalists have presented themselves as the watchdog of government, a Fourth Estate. The ideals of freedom of the press and objectivity of news are revered as sacred institutions.

Current research on newsmaking is questioning profoundly the validity of these claims. Some researchers conclude that the snippets ofinformation in the evening news cover over deeper issues and only create an illusion of being informed. TV news is increasingly designed as entertainment, little different &om the soaps that …

Broadcasting Policy And Media Reform

Communication Research Trends

In some nations broadcasting evolves steadily and organically into a system that serves the information and leisure needs of an ever broader range of social groups. The media stimulate a widespread, critical and informed debate on national issues. In other countries broadcasting tends to become the preserve of powerful minority interests, and all information is slanted, often subtly, to serve the power strategies of these interests. Wave after wave of public "media reform" protest crashes against these privileged minorities, hut the established controls remain virtually intact. What has communication research to say to this problem?

Mental Health Counselors’ Perceptions Of Professional Identity As Correctional Counselors In An Integrated Behavioral Healthcare Setting, Jeanel L. Franklin, Kevin C. Snow, Edward S. Neukrug

Journal of Human Services Scholarship and Interprofessional Collaboration

This interpretive phenomenological study of four individuals examined clinical mental health counselors (MHCs) in a correctional integrated behavioral healthcare (IBH) setting to the purpose of examining how the unique experiences and roles of MHCs employed as correctional counselors in an IBH setting impacted the perceptions of their professional identity/development as counselors. Findings indicated how environment, work relationships, and multiple foci of mental health roles contributed to professional growth and identity development. Participants experienced an adaptive transitional process when applying counseling styles to the setting and population as well as integrating experiences as correctional counselors into pre-existing professional identities. Practical implications …

Framework For Multi-Resource Condition Evaluation, Pihu Gupta, Abhishek Rathi, Nitin Garg

Defensive Publications Series

In many computing scenarios, ensuring a desired state or enforcing a policy for a cloud workload requires considering the relationships and dependencies between distinct entities, resources, or assets. Traditional approaches that focus on the properties and configurations of single resources or assets can prevent accurate assessment of requirements. This disclosure describes techniques to evaluate conditions and constraints that involve multiple, disparate types of resources or entities. The techniques include resource identification and relationship mapping; data retrieval; cross-resource constraint evaluation; result aggregation and reporting; etc. A generic framework and data model define and evaluate conditions that span the boundaries of individual …

Intelligence Reform At 20: How Joint Military Intelligence Lost Its Groove And How To Get It Back, Laura J. Coco-Hampton, Karalee G. Picard

Joint Force Quarterly

On the 20-year anniversary of the Intelligence Reform and Terrorist Prevention Act (IRTPA), two DIA officers examine the impact of analytic tradecraft reforms and the over-emphasis on intelligence analyst skills over intelligence product outputs, particularly to the Joint Force. As a result, a large number of intelligence analysts no longer speak the same language as the Joint Force, instead adhering exclusively to analytic tradecraft and processes developed independent from joint doctrine warfighter support requirements. This paper aims to identify and outline structural reasons behind key gaps in intelligence analytic support to the Joint Force and also to recommend changes to …

The Insurgent’S Dilemma: A Struggle To Prevail, David E. Spencer

Joint Force Quarterly

David E. Spencer’s review of The Insurgent’s Dilemma highlights David Ucko’s nuanced analysis of the strategic challenges insurgent movements face in balancing military efficacy with political legitimacy. Drawing on his expertise in Latin American insurgency, particularly the FARC, Spencer uses Ucko’s framework to explain why some insurgent groups, like the FARC, failed to adapt to post-Cold War conditions, while others, like the Zapatistas, successfully evolved ideologically, locally, and institutionally. Ucko argues that modern insurgencies must navigate complex trade-offs between violence and popular support, especially as traditional strategies become obsolete. The book offers critical insights into how both insurgents and counterinsurgents …

Space Warfare: Strategy, Principles And Policy, 2nd Ed., Todd W. Pennington, Emmy Kanarowski

Joint Force Quarterly

The second edition of Space Warfare by John J. Klein offers a timely and comprehensive update to a foundational text in spacepower strategy. Reviewed by Pennington and Kanarowski, this expanded volume deepens Klein’s signature analogies between maritime and space domains while addressing the significant geopolitical, doctrinal, and legal changes that have reshaped military space operations since the book’s original release in 2006. Notable additions include new chapters on space-based offensive and defensive platforms, “Guardian Angels” and “Celestial Demons,” and a thought-provoking call for a future Space National Guard. While some proposals are forward-looking, Klein’s work remains grounded in strategic theory, …

Human, Machine, War: How The Mind-Tech Nexus Will Win Future Wars, Frank Hoffman

Joint Force Quarterly

In his review of Human, Machine, War, Frank Hoffman explores a timely and thought-provoking anthology that examines how the fusion of human cognition and advanced technologies will define success in future warfare. Edited by Nicholas Wright, Michael Miklaucic, and Todd Veazie, the book argues that winning tomorrow’s conflicts hinges not just on technological superiority, but on mastering the interplay between human factors and emerging capabilities like AI, neuroscience, and cognitive enhancement. Featuring insights from leading defense thinkers, including retired Lieutenant General Jack Shanahan and defense neuroscientist James Giordano, the volume delves into the ethical, operational, and strategic dimensions of …

The Long Pivot: The Development Of The Joint Warfighting Concept, Wilson C. Blythe Jr.

Joint Force Quarterly

Military strategy evolves in response to global threats and technological advancements. This article examines the development of the Joint Warfighting Concept, a pivotal shift in U.S. military thinking towards confronting peer adversaries. The concept emerged from a process of reorienting the Department of Defense away from counterinsurgency operations and towards potential conflicts with modernized Russian and Chinese forces. Initially hindered by a lack of urgency, efforts to address this strategic shift gained momentum through initiatives like the Third Offset Strategy and subsequent national security documents. The Joint Warfighting Concept provides a unified vision for future warfare, guiding force modernization and …

A Conditions-Based Look At A Cyber Force, Shiraz Khan

Joint Force Quarterly

As global competition in the cybersphere increases, questions about the United States’ capability in the cybersphere also increase. This paper examines the current conditions surrounding the discussion of U.S. cyber capability and determines if the conditions surrounding the discussion that led to the creation of The United States Air Force and The United States Space Force exist for the cyber conditions today.

Using the process model used in Bruno Dyck and Frederick Starke’s “The Formation of Breakaway Organizations: Observations and a Process Model” this paper analyzes the stages and triggers that led to new organizations breaking away from their parent …

Revive: Getting Medical Supplies And Expertise Right In Distributed Maritime Operations, Seth Reini, Jonathan J. Haase

Joint Force Quarterly

In recent conflicts, military medical providers have set impressive records for battlefield care, setting a “golden hour” precedent. In a conflict with the People's Republic of China, however, the “golden hour” aspiration will be severely challenged if not untenable. Here, the paradigm will be Distributed Maritime Operations, air superiority will be challenged, and vast distances exist between treatment locations. With patients potentially being held for hours or days, updated medical treatment strategies, logistics methodologies, and transport capabilities will be necessary. This paper focuses on leveraging Military Sealift Command platforms for multi-mission usage by transporting medical supplies to Navy ships in …

Increasing Operational Access: A Strategy For The Western Pacific, Shaun F. Callahan

Joint Force Quarterly

This article presents a comprehensive argument for why the United States must enhance its military and strategic mobility in the Western Pacific to counter the People’s Republic of China’s (PRC) growing regional assertiveness. The article contends that maintaining a Free and Open Indo-Pacific requires a whole-of-government approach to operational access, blending diplomatic outreach, economic engagement, strategic communication, and military posture. Current U.S. basing and access agreements, rooted in Cold War dynamics, no longer suffice for effective power projection in today’s contested environment. To enable integrated deterrence and flexible crisis response, the United States must expand distributed access points, deepen partnerships, …

T-Birrd: Transforming The Future Of Military And Humanitarian Logistics, Jacob R. Bright

Joint Force Quarterly

Terrestrial Based Inserted Rocket Resource Delivery (T-BIRRD), Also Known as “Rocket Cargo” or “Point to Point Delivery”, represents a significant leap in the field of logistics, leveraging the capabilities of large commercial rockets to enhance the responsiveness and effectiveness of military operations and humanitarian efforts. This paper delves into the strategic advantages, operational controls, and legal implications associated with the use of T-BIRRD, framing it as a critical evolution in logistical practices.

This paper refers to the capability of rocket cargo delivery as T-BIRRD, a name chosen for its specificity, and clear differentiation from existing systems using rockets to deliver …

Finding Deepfakes: A Tabletop Exercise About Ai, Decisionmaking, And Algorithmic Performance, Andrea Brennan, Gwyneth Sutherlin, Lisa Pagano-Wallace, Hermie Mendoza

Joint Force Quarterly

This article explores a first-of-its-kind tabletop exercise designed to expose U.S. military and national security professionals to the real-world challenges of using AI tools like deepfake detectors in high-stakes decisionmaking. Set in a fictional scenario involving a flawed AI system, participants confronted algorithmic bias, technical uncertainty, and ethical dilemmas, revealing how AI limitations can erode trust in intelligence products. Drawing from student and faculty reflections, the article highlights the importance of preparing future leaders to scrutinize and manage AI performance failures not only as technical bugs but as complex, systemic issues with social and operational consequences. The exercise underscored the …

The Philosophical Foundations Of The Civil-Military Relationship, John Mark Mattox

Joint Force Quarterly

This article reexamines civil-military relations through a philosophical lens, arguing that they are far more complex than simple military subordination to civilian authority. Drawing on foundational models from Hobbes, Plato, medieval Christendom, and Clausewitz, it reveals a recurring tripartite structure of society: rulers, warriors, and citizens bound together by mutual responsibility and moral obligation. From Plato’s emphasis on virtue and justice to Clausewitz’s "paradoxical trinity" of people, military, and government, the article shows that the strength of any state depends on trust and collaboration among all three. True civil-military relations, it concludes, must be understood as a dynamic moral partnership …

Building Strategic Lethality: Special Operations Models For Joint Force Learning And Leader Development, Spencer B. Meredith Iii

Joint Force Quarterly

This article examines how U.S. Joint Special Operations Forces (SOF), particularly through SAG-U and CJSOTF-10, have rapidly adapted to support Ukraine amid Russia’s full-scale invasion, offering a model for future joint force innovation. SAG-U emerged as a key logistics and coordination hub, integrating NATO and interagency partners to manage complex, high-stakes supply chains. Meanwhile, CJSOTF-10 and its subordinate SOTF-10.1 shifted from traditional training and advising roles to rapid tactical adaptation, virtual assistance, and technological integration to meet evolving battlefield demands. The creation of the Remote Advise and Assist Cell (RAAC) illustrates how remote support and real-time data can bridge operational …

From High Seas To Highlands: Framing U.S. Defense Strategy With Southeast Asia’S Geography, Caitlin P. Irby

Joint Force Quarterly

The 2022 United States National Security Strategy prioritized competing with China and this focus seems likely to continue with the new administration.[i] Southeast Asia’s growing economic relevance and proximity to China mean that the US can secure significant gains on numerous goals by focusing on this region. To support developing an appropriate strategy, this paper identifies what features make Southeast Asia relevant to the US, potential flashpoints for conflict, and outlines the characteristics of a potential conflict. With this information the author then proposes specific steps to ensure that the United States military maintains the capability to protect US …

Rightsizing The Pla Air Force: Revisiting An Analytic Framework, Lauren Edson, Phillip C. Saunders

Joint Force Quarterly

This article evaluates the modernization of the People’s Liberation Army Air Force (PLAAF) from 2007 to 2025 using the Saunders-Quam framework, which identifies four core trade-offs: changes in roles and missions, domestic versus foreign procurement, high-tech versus low-tech systems, and combat versus support aircraft. While the framework remains a useful analytical tool, it underestimated the Chinese Communist Party’s willingness to fund expensive modernization efforts and the rapid advancements in China’s defense industrial base. The article identifies key factors missing from the original framework such as doctrinal shifts, increased emphasis on counterintervention, maritime expansion, and the rise of unmanned systems. It …