Digital Commons Network^™

July 15, 2025 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

Facts And Hopes: Toward The Next Quantum Leap In Melanoma, Keith T Flaherty, Andrew E Aplin, Michael A Davies, Nir Hacohen, Meenhard Herlyn, Dave Hoon, Patrick Hwu, Michal Lotem, James Mulé, Jennifer A Wargo, David E Fisher

Faculty, Staff and Student Publications

Outcomes from advanced melanoma, the deadliest of the skin cancers arising from melanocytes and capable of widely metastasizing, have greatly improved, with death rates decreasing for patients with American Joint Committee on Cancer stage 4 melanoma by 3% to 5% annually over the past 10 years. This improvement is a result of advances in both targeted therapy and immunotherapy. BRAF and MEK inhibitors for advanced melanoma have led the way for targeted cancer strategies and first-in-class approvals for immune checkpoint blockers targeting CTLA4, PD-1, and LAG3; T-cell engager therapy targeting the antigen gp100; and tumor-infiltrating lymphocyte therapy. All of these …

Technology Roadmap Of Micro/Nanorobots, Xiaohui Ju, Chuanrui Chen, Cagatay M Oral, Semih Sevim, Ramin Golestanian, Mengmeng Sun, Negin Bouzari, Xiankun Lin, Mario Urso, Jong Seok Nam, Yujang Cho, Xia Peng, Fabian C Landers, Shihao Yang, Azin Adibi, Nahid Taz, Raphael Wittkowski, Daniel Ahmed, Wei Wang, Veronika Magdanz, Mariana Medina-Sánchez, Maria Guix, Naimat Bari, Bahareh Behkam, Raymond Kapral, Yaxin Huang, Jinyao Tang, Ben Wang, Konstantin Morozov, Alexander Leshansky, Sarmad Ahmad Abbasi, Hongsoo Choi, Subhadip Ghosh, Bárbara Borges Fernandes, Giuseppe Battaglia, Peer Fischer, Ambarish Ghosh, Beatriz Jurado Sánchez, Alberto Escarpa, Quentin Martinet, Jérémie Palacci, Eric Lauga, Jeffrey Moran, Miguel A Ramos-Docampo, Brigitte Städler, Ramón Santiago Herrera Restrepo, Gilad Yossifon, James D Nicholas, Jordi Ignés-Mullol, Josep Puigmartí-Luis, Yutong Liu, Lauren D Zarzar, C Wyatt Shields, Longqiu Li, Shanshan Li, Xing Ma, David H Gracias, Orlin Velev, Samuel Sánchez, Maria Jose Esplandiu, Juliane Simmchen, Antonio Lobosco, Sarthak Misra, Zhiguang Wu, Jinxing Li, Alexander Kuhn, Amir Nourhani, Tijana Maric, Ze Xiong, Amirreza Aghakhani, Yongfeng Mei, Yingfeng Tu, Fei Peng, Eric Diller, Mahmut Selman Sakar, Ayusman Sen, Junhui Law, Yu Sun, Abdon Pena-Francesch, Katherine Villa, Huaizhi Li, Donglei Emma Fan, Kang Liang, Tony Jun Huang, Xiang-Zhong Chen, Songsong Tang, Xueji Zhang, Jizhai Cui, Hong Wang, Wei Gao, Vineeth Kumar Bandari, Oliver G Schmidt, Xianghua Wu, Jianguo Guan, Metin Sitti, Bradley J Nelson, Salvador Pané, Li Zhang, Hamed Shahsavan, Qiang He, Il-Doo Kim, Joseph Wang, Martin Pumera

Faculty, Staff and Student Publications

Inspired by Richard Feynman’s 1959 lecture and the 1966 film Fantastic Voyage, the field of micro/nanorobots has evolved from science fiction to reality, with significant advancements in biomedical and environmental applications. Despite the rapid progress, the deployment of functional micro/nanorobots remains limited. This review of the technology roadmap identifies key challenges hindering their widespread use, focusing on propulsion mechanisms, fundamental theoretical aspects, collective behavior, material design, and embodied intelligence. We explore the current state of micro/nanorobot technology, with an emphasis on applications in biomedicine, environmental remediation, analytical sensing, and other industrial technological aspects. Additionally, we analyze issues related to …

The Integrated Stress Response Pathway Coordinates Translational Control Of Multiple Immune Checkpoints In Lung Cancer, Shayna Thomas-Jardin, Shruthy Suresh, Ariana Arce, Nicole Novaresi, Qing Deng, Emily Stein, Lisa Thomas, Cheryl Lewis, Chul Ahn, Bret M Evers, Esra A Akbay, Maria E Salvatierra, Wei Lu, Khaja Khan, Luisa M Solis Soto, Ignacio I Wistuba, John D Minna, Kathryn A O'Donnell

Faculty, Staff and Student Publications

The integrated stress response (ISR) is an adaptive pathway hijacked by cancer cells to survive cellular stresses in the tumor microenvironment. ISR activation potently induces PD-L1, leading to suppression of antitumor immunity. In this study, we sought to uncover additional immune checkpoint proteins regulated by the ISR to elucidate mechanisms of tumor immune escape. The ISR coordinately induced cluster of differentiation 155 (CD155) and PD-L1, enhancing translation of both immune checkpoint proteins through bypass of inhibitory upstream open reading frames in their 5' untranslated regions. Analysis of primary human lung tumors identified a significant correlation between expression of PD-L1 and …

Targeting The Cd40 Costimulatory Receptor To Improve Virotherapy Efficacy In Diffuse Midline Gliomas, Sara Labiano, Javier Marco-Sanz, Iker Ausejo-Mauleon, Virginia Laspidea, Reyes Hernández-Osuna, Marc Garcia-Moure, Daniel De La Nava, Sara Nuin, Marisol Gonzalez-Huarriz, Timothy N Phoenix, Ibon Tamayo, Marta Zalacain, Andrea Lacalle, Lucía Marrodan, Montserrat Puigdelloses, Irati Hervás-Corpión, Maria C Ochoa, Noelia Casares, Oren J Becher, Candelaria Gomez-Manzano, Juan Fueyo, Jaime Gallego Perez-Larraya, Ana Patiño-Garcia, Marta M Alonso

Faculty, Staff and Student Publications

Diffuse midline glioma (DMG) is a devastating pediatric brain tumor. The oncolytic adenovirus Delta-24-RGD has shown promising efficacy and safety in DMG patients but is not yet curative. Thus, we hypothesized that activating dendritic cells (DCs) through the CD40 costimulatory receptor could increase antigen presentation and enhance the anti-tumor effect of the virus, resulting in long-term responses. This study shows that the intratumoral co-administration of Delta-24-RGD and a CD40 agonistic antibody is well tolerated and induces long-term anti-tumor immunity, including complete responses (up to 40%) in DMG preclinical models. Mechanistic studies revealed that this therapy increased tumor-proliferating T lymphocytes and …

Page 06: Seizing Robles Pond, Kaleigh Hoyt

Zion Cemetery Digital Poster Collection

Page 6 of 12 of the LHI Zion Cemetery Poster Project (FLDOS). Download to view in high resolution.

What Can We Learn From The High School Math Reform Efforts In California, Georgia, And Oregon? A Policy Analysis, Yanira Vazquez

Teacher Education, Educational Leadership & Policy ETDs

Using publicly available data sources, this policy analysis examined how three states—California, Georgia, and Oregon—approached high school mathematics reforms to address questions regarding what prompted these states to revise their high school math standards and course pathways; how their approaches to reform were similar or different; and what other states could learn from their methods.

Individual state cases were developed, focusing on content standards, course pathways, and graduation requirements. A cross-case study was created to compare reforms from the three states.

While all states aimed to reform high school mathematics to address equity issues and offer options aligned with students’ …

Sensory Neuron-Expressed Fgf13 Controls Nociceptive Signaling In Diabetic Neuropathy Models, Aditya K Singh, Matteo Bernabucci, Nolan M Dvorak, Zahra Haghighijoo, Jessica Di Re, Nana A Goode, Feni K Kadakia, Laura A Maile, Olumarotimi O Folorunso, Paul A Wadsworth, Cynthia M Tapia, Pingyuan Wang, Jigong Wang, Haiying Chen, Yu Xue, Jully Singh, Kali Hankerd, Isaac J Gamez, Makenna Kager, Vincent Truong, Patrick Walsh, Stephanie I Shiers, Nishka Kuttanna, Hanyue Liao, Margherita Marchi, Erika Salvi, Ilaria D'Amato, Daniela D'Amico, Parsa Arman, Catharina G Faber, Rayaz A Malik, Marina De Tommaso, Dan Ziegler, Krishna Rajarathnam, Thomas A Green, Peter M Grace, Matthew R Sapio, Michael J Iadarola, Gregory D Cuny, Diana S Chow, Giuseppe Lauria Pinter, Steve Davidson, Dustin P Green, Jun-Ho La, Jin Mo Chung, Jia Zhou, Theodore J Price, Elizabeth Salisbury, Subo Yuan, Fernanda Laezza

Faculty, Staff and Student Publications

Nociception involves complex signaling, yet intrinsic mechanisms bidirectionally regulating this process remain unexplored. Here, we show that the fibroblast growth factor 13 (FGF13)/Nav1.7 protein-protein interaction (PPI) complex bidirectionally modulates nociception, and that the FGF13/Nav1.7 ratio is upregulated in type 2 diabetic neuropathy (T2DN). PW164, an FGF13/Nav1.7 channel C-terminal tail domain (CTD) PPI interface inhibitor, which reduces complex assembly, selectively suppressed Na+ currents sensitized by capsaicin-induced activation of TRPV1 channels in human induced pluripotent stem cell-derived (hIPSC-derived) sensory neurons and inhibited mechanical and thermal hyperalgesia in mice. FGF13 silencing mimics PW164 activity in culture and in vivo. Conversely, ZL192, an FGF13 …

Fgfr3-Induced Y158 Parp1 Phosphorylation Promotes Parp Inhibitor Resistance Via Brg1/Mre11-Mediated Dna Repair In Breast Cancer Models, Mei-Kuang Chen, Hirohito Yamaguchi, Yuan Gao, Weiya Xia, Jeffrey T Chang, Yu-Chun Hsiao, Tewodros W Shegute, Zong-Shin Lin, Chen-Shiou Wu, Yu-Han Wang, Jennifer K Litton, Qingqing Ding, Yongkun Wei, Yu-Yi Chu, Funda Meric-Bernstam, Helen Piwnica-Worms, Banu Arun, Jordi Rodon Ahnert, Jinsong Liu, Jun Yao, Wei-Chao Chang, Hung-Ling Wang, Coya Tapia, Constance T Albarracin, Khandan Keyomarsi, Shao-Chun Wang, Ying-Nai Wang, Gabriel N Hortobagyi, Chunru Lin, Liuqing Yang, Dihua Yu, Mien-Chie Hung

Faculty, Staff and Student Publications

Poly(ADP-ribose) polymerase (PARP) inhibitors (PARPis) are used to treat BRCA-mutated (BRCAm) cancer patients; however, resistance has been observed. Therefore, biomarkers to indicate PARPi resistance and combination therapy to overcome that are urgently needed. We identified a high prevalence of activated FGF receptor 3 (FGFR3) in BRCAm triple-negative breast cancer (TNBC) cells with intrinsic and acquired PARPi resistance. FGFR3 phosphorylated PARP1 at tyrosine 158 (Y158) to recruit BRG1 and prolong chromatin-loaded MRE11, thus promoting homologous recombination (HR) to enhance PARPi resistance. FGFR inhibition prolonged PARP trapping and synergized with PARPi in vitro and in vivo. High-level PARP1 Y158 phosphorylation (p-Y158) positively …

Medpix®: Database Of Medical Images, Teaching Cases, And Clinical Topics, Alex Henigman, Brandon Kennedy

Library Staff Publications

MedPix is a free, open-access, online database developed by the National Library of Medicine that houses a vast collection of over 59,000 medical images, 12,000 patient cases, and 9,000 clinical topics. Designed to support both teaching and self-directed learning, the platform serves a diverse audience including physicians, medical students, educators, and researchers. MedPix offers robust search capabilities as well as case-based learning tools that support Continuing Medical Education.

Integrating Artificial Intelligence And Machine Learning Technologies Into Common Operating Picture And Course Of Action Development, C. Anthony Pfaff, Christopher John Hickey

Books, Monographs & Collaborative Studies

C. Anthony Pfaff and Christopher John Hickey, Principal Investigators

©2025 C. Anthony Pfaff. All rights reserved.

Integrating Artificial Intelligence and Machine Learning Technologies into Common Operating Picture and Course of Action Development explores the potential of artificial intelligence (AI) and machine learning to revolutionize military planning processes by enhancing situational awareness and expediting course of action development within the Joint planning process. The study delves into technical, organizational, and resource considerations that are critical for AI integration. In addition, the study highlights the importance of clean, structured data in training AI systems, addresses challenges in data collection across varying formats …

Non-Invasive Telemonitoring In Heart Failure: A Systematic Review, Patrick A. Kwaah, Emmanuel Olumuyide, Kassem Farhat, Barbara Malaga-Espinoza, Ahmed Abdullah, Michael H. Beasley, Novi Y. Sari, Lily K. Stern, Julio A. Lamprea-Montealegre, Adrian Dasilva-Deabreu, Jiun-Ruey Hu

School of Medicine Publications

Background and Objectives: Heart failure (HF) represents a major public health challenge worldwide, with rising prevalence, high morbidity and mortality rates, and substantial healthcare costs. Non-invasive telemonitoring has emerged as a promising adjunct in HF management, yet its clinical effectiveness remains unclear. Materials and Methods: In this systematic review, we summarize randomized controlled trials (RCTs) between 2004 and 2024 examining the efficacy of non-invasive telemonitoring on mortality, readmission, and quality of life (QoL) in HF. In addition, we characterize the heterogeneity of features of different telemonitoring interventions. Results: In total, 32 RCTs were included, comprising 13,294 participants. While some individual …

Radial Velocities And Stellar Populations For A Sample Of Matlas Survey Dwarfs, Kate Southon, Jonah S. Gannon, Duncan A. Forbes, Arsen Levitskiy, Maria Luisa Buzzo, Aaron J. Romanowsky, Jean P. Brodie

Faculty Research, Scholarly, and Creative Activity

Spectroscopic observations are essential for confirming associations, measuring kinematics, and determining stellar populations in dwarf galaxies. Here, we present Keck Cosmic Web Imager spectra for 12 MATLAS survey dwarfs. For 9, we confirm recession velocities consistent with their literature-assumed host galaxies. We propose revisions of the host galaxy associations for MATLAS-631, 1494, and 1938. For MATLAS-1494, our measured redshift reclassifies it from an ultra-diffuse galaxy candidate to a dwarf galaxy that is of smaller physical size and places it in the field. It also appears old and passive, providing a challenge to models that invoke quenching by tidal effects. Additionally, …

With Vim And Courage: Confederate Soldiers And The Politics Of War, Michelle N. Norello

LSU Master's Theses

The Confederate cause has captivated historians for many decades. At first glance, the Confederacy embodies a persistent effort to promote white supremacy, the planter class, and independence. While this assessment is accurate, individual Confederate soldiers possess diverse narratives that both challenge and support the labels assigned over the years. The political dimension of the Civil War opens new avenues for scholarly exploration concerning Confederate soldiers. But what insights might this offer regarding the nature of the Confederacy, civilian political engagement, and democracy? The answer to this question is complex and nonlinear. Previous research has acknowledged the numerous reasons why Confederate …

The Design And Effect Of Continuum Robot Compliance On Locomotion, Parsa Molaei

LSU Doctoral Dissertations

Continuum robots, due to their compliant structures and ability to navigate through constrained environments, offer significant advantages in applications requiring safe physical interaction and dexterous motion. However, challenges related to limited structural stiffness, payload capacity, and precise control remain open problems in the field. This dissertation presents novel contributions aimed at addressing these limitations through two main actuation units of continuum robots: tendon-driven continuum robots (TDCRs) and concentric tube robots (CTRs). In the first part, we focus on methods to improve the stability and modify the stiffness of the TDCR. A tendon decoupling strategy is introduced for planar TDCRs. The …

A Systems Engineering Approach To Improve Alarm Management And Nurse Mental Workload, Benjamin D. Elmore

LSU Doctoral Dissertations

Alarm fatigue has been a consistent problem nurses have experienced for decades. The effects of excessive nuisance alarms leads to adverse effects such as desensitization, missed alarms, frustration, and increased risk to patient safety. Other research has provided explanations on alarm fatigue causes and developed solutions for reducing nuisance alarms or minimizing effects, but few have examined the problem from a sociotechnical systems perspective. This study applied the Systems Engineering Initiative for Patient Safety (SEIPS) framework to define, design, and test an alarm management intervention compatible with a Progressive Care Unit (PCU)’s sociotechnical subsystems. The SEIPS application is unique from …

Resilience And Traumatic Stress Among Latinx English Language Learners: A Cross-Sectional Study Of Students From An Urban School District, Roya Ijadi-Maghsoodi, Sara Rahmanian Koushkaki, Alexandra Klomhaus, Hilary Aralis, Angela Venegas-Murillo, Lauren Marlotte, Sameera Siddiqi, Kungeun Lee, Shirley A De La Cruz, Sheryl Kataoka

Staff and Researcher Publications

Background: Latinx students in the United States can face stressors and structural inequities that can lead to poor academic and mental health outcomes. They comprise 76% of the English Language Learner (ELL) population, yet little is known about the relationship between ELL status and traumatic stress and resilience outcomes among these Latinx students. We sought to see if resilience differs between ELL vs. non-ELL Latinx students, and if traumatic stress risk modifies the association between ELL designation and resilience among Latinx students to inform culturally relevant school resilience interventions and school-wide approaches for this population.

Methods: We analyzed deidentified school …

Serum Metabolomic Profiling Of Incident Type 2 Diabetes Mellitus In The Multi-Ethnic Study Of Atherosclerosis And Rotterdam Study, Xuanwei Jiang, Fang Zhu, Gonçalo Graça, Xihao Du, Jinjun Ran, Fariba Ahmadizar, Alexis C Wood, Yanqiu Zhou, Denise M Scholtens, Ali Farzaneh, M Arfan Ikram, Alan Kuang, Carel W Le Roux, Meghana D Gadgil, Marilyn C Cornelis, Kent D Taylor, Xiuqing Guo, Mohsen Ghanbari, Laura J Rasmussen-Torvik, Russell P Tracy, Alain G Bertoni, Jerome I Rotter, David M Herrington, Philip Greenland, Maryam Kavousi, Victor W Zhong

Children’s Nutrition Research Center Staff Publications

Objective: This study aimed to investigate serum metabolomic biomarkers associated with incident type 2 diabetes mellitus (T2DM) and evaluate their performance in improving T2DM risk prediction.

Methods: Untargeted proton nuclear magnetic resonance (1H NMR) spectroscopy-based metabolomics analyses were conducted in the Multi-Ethnic Study of Atherosclerosis (MESA; n = 3460; discovery cohort) and The Rotterdam Study (RS; n = 1556; replication cohort). Multivariable cause-specific hazards models were used to analyze the associations between 23 571 serum metabolomic spectral variables and incident T2DM. Replicated metabolites required an false discovery rate-adjusted P < .01 in MESA, P < .05 in RS, and consistent direction of association. Pathway and network analyses were conducted to elucidate biological mechanisms underlying T2DM development. The utility of the replicated metabolites in improving T2DM risk prediction was assessed based on the Framingham Diabetes Risk Score. A 2-sample Mendelian randomization was conducted to assess causal associations.

Results: Nineteen metabolites were significantly associated with incident T2DM. Pathway analyses …

Epha4 Signaling Dysregulation Links Abnormal Locomotion And The Development Of Idiopathic Scoliosis, Lianlei Wang, Xinyu Yang, Sen Zhao, Pengfei Zheng, Wen Wen, Kexin Xu, Xi Cheng, Qing Li, Anas M Khanshour, Yoshinao Koike, Junjun Liu, Xin Fan, Nao Otomo, Zefu Chen, Yaqi Li, Lulu Li, Haibo Xie, Panpan Zhu, Xiaoxin Li, Yuchen Niu, Shengru Wang, Sen Liu, Suomao Yuan, Chikashi Terao, Ziquan Li, Shaoke Chen, Xiuli Zhao, Pengfei Liu, Jennifer E Posey, Zhihong Wu, Guixing Qiu, Disco Study Group (Deciphering Disorders Involving Scoliosis & Comorbidities), Shiro Ikegawa, James R Lupski, Jonathan J Rios, Carol A Wise, Jianguo T Zhang, Chengtian Zhao, Nan Wu

Faculty, Staff and Students Publications

Idiopathic scoliosis (IS) is the most common form of spinal deformity with unclear pathogenesis. In this study, we first reanalyzed the loci associated with IS, drawing upon previous studies. Subsequently, we mapped these loci to candidate genes using either location-based or function-based strategies. To further substantiate our findings, we verified the enrichment of variants within these candidate genes across several large IS cohorts encompassing Chinese, East Asian, and European populations. Consequently, we identified variants in the EPHA4 gene as compelling candidates for IS. To confirm their pathogenicity, we generated zebrafish mutants of epha4a. Remarkably, the zebrafish epha4a mutants exhibited …

Role Of Lipoprotein(A) In Atherosclerotic Cardiovascular Disease In South Asian Individuals, Darshan Patel, Marlys L Koschinsky, Anandita Agarwala, Pradeep Natarajan, Harpreet S Bhatia, Anurag Mehta, Jaideep Patel, Matthew Peters, Shreya Pandya, Usman Sagheer, Raman Puri, Salim S Virani, Dinesh K Kalra

Faculty, Staff and Students Publications

South Asian individuals (SA), representing approximately one quarter of the global population, experience a disproportionately high burden of cardiovascular disease. Some of this increased susceptibility is accounted for by traditional risk factors such as diabetes, hypertension, carbohydrate-rich diets, and rising rates of obesity and metabolic syndrome. However, other previously underappreciated risk factors may also play a crucial role. These include environmental pollution, genetic factors, and Lp(a) (lipoprotein(a)). Various epidemiological and genetic studies support the role of Lp(a) as a causal and independent risk factor for atherosclerotic cardiovascular disease. SA have a higher prevalence of elevated Lp(a) levels (25% have levels …

X-Linked Hypophosphatemia Management In Adults: An International Working Group Clinical Practice Guideline., Aliya A. Khan, Dalal S. Ali, Natasha M. Appelman-Dijkstra, Thomas O. Carpenter, Catherine Chaussain, Erik A. Imel, Suzanne M. Jan De Beur, Pablo Florenzano, Hajar Abu Alrob, Rana Aldabagh, R Todd Alexander, Farah Alsarraf, Signe Sparre Beck-Nielsen, Martin Biosse-Duplan, Martine Cohen-Solal, Rachel K. Crowley, Karel Dandurand, Guido Filler, Lisa Friedlander, Seiji Fukumoto, Claudia Gagnon, Paul Goodyer, Corinna Grasemann, Chelsey Grimbly, Salma Hussein, Muhammad K Javaid, Sarah Khan, Aneal Khan, Anna Lehman, Willem F. Lems, E Michael Lewiecki, Ciara Mcdonnell, Reza D. Mirza, Emmett Morgante, Archibald Morrison, Anthony A. Portale, Yumie Rhee, Eric T. Rush, Heide Siggelkow, Sotirios Tetradis, Laura Tosi, Leanne M. Ward, Gordon Guyatt, Maria Luisa Brandi

Manuscripts, Articles, Book Chapters and Other Papers

PURPOSE: An international working group (IWG) consisting of experts in X-linked hypophosphatemia (XLH) developed global guidelines providing a comprehensive, evidence-based approach to XLH diagnosis, management, and monitoring.

METHODS: The IWG, consisting of 43 members as well as methodologists and a patient partner, conducted 2 systematic reviews (SRs) and narrative reviews to address key areas. The SRs addressed the impact of burosumab compared to conventional therapy (phosphate and active vitamin D) or no therapy on patient-important outcomes in adults. They also evaluated conventional therapy compared to no therapy. GRADE methodology was applied to evaluate the certainty of evidence. Non-GRADED recommendations were …

Role Of Nurses And Allied Health Professionals In Hepatology And The Challenges Faced When Navigating A Career Pathway, Lynsey Spillman, Dianne Backhouse, Leah Cox, Katie Ballesteros, Katie Ramos, Felicity Williams

School of Health Professions

Hepatology specialist nurses and allied health professionals (AHPs), including dietitians and physiotherapists, are essential members of the multidisciplinary team, delivering person-centred care from prevention through to advanced disease. Their contributions support lifestyle intervention, symptom management and care coordination, improving patient outcomes and service efficiency. Despite this, roles remain underfunded, inconsistently embedded and often overlooked in workforce planning. This article outlines the impact and challenges facing hepatology nurses and AHPs, drawing on UK service examples that demonstrate improved quality of life, reduced admissions, recompensation and cost savings. Barriers include limited access to structured training, protected time and clearly defined career pathways. …

Identity Development, Attraction, And Behavior Of Heterosexual-Identified Men Who Have Sex With Men: A Scoping Review, Andrew D. Eaton, Travis R. Scheadler, Melanie Mcdonald, Oliver Beer, Lauren B. Mcinroy, Erin Beckwell, Adam Busch, Cara Bradley, Paul A. Shuper

School of Health Professions

Introduction: Heterosexual-identified men who have sex with men (H-MSM) experience sexual identity and behavior discordance. H-MSM may comprise 0.5–3.5% of adult heterosexual men. Understanding and accepting H-MSM as they self-identify may be necessary to implement effective public health and psychosocial interventions. This scoping review synthesizes research on H-MSM’s identity development, attraction, and behavior. Methods: Thirteen databases were searched and, using Covidence software, two independent reviewers screened 3617 titles and abstracts and 269 full texts to arrive at 124 articles meeting entry criteria. Ten independent reviewers then conducted thematic content analysis. Results:H-MSM either expressed sexual identity uncertainty or justified maintaining heterosexual …

Distribution Of Alkylamines In Surface Waters Around The Antarctic Peninsula And Weddell Sea, Arianna Rocchi, Mark F. Fitzsimons, Preston Chebai Akenga, Ana Sotomayor, Elisabet L. Sà, Queralt Güell-Bujons, Magda Vila, Yaiza M. Castillo, Manuel Dall'osto, Dolors Vaqué, Charel Wohl, Rafel Simó, Elisa Berdalet

School of Geography, Earth and Environmental Sciences

Alkylamines, volatile organic nitrogen compounds with low molecular weight, are present in the surface ocean and participate in the marine biogeochemical nitrogen cycle, atmospheric chemistry and cloud formation. Alkylamines have been detected in polar regions, suggesting that these areas constitute emission hotspots of these compounds. However, knowledge of the sea surface distribution patterns and factors modulating alkylamines remain limited due to their high reactivity and low concentrations, which hamper accurate measurements. We investigated the presence and distribution of alkylamines in seawaters around the Antarctic Peninsula and the northern Weddell Sea during the late austral summer and explored their potential links …

Heart Failure With Reduced Ejection Fraction Polypill Implementation Strategy In Sri Lanka: Design And Protocol Of A Pilot Type I Hybrid Randomised Clinical Trial, Anubha Agarwal, Mansi Agarwal, Charles W. Goss, Adam Hively, Mark D. Huffman, Et Al.

2020-Current year OA Pubs

No abstract provided.

H2-Rich Biogas Production From Fixed Bed Wheat Straw Pyrolysis And The Potential Of Produced Biochar As H2 Storage Material, Tawanda Matamba, Hussein Rasool Abid, Alireza Keshavarz, Stefan Iglauer

Research outputs 2022 to 2026

H2 is a clean energy source, and is targeted as one of the ways to transition from fossil fuels. However, there are drawbacks in production and storage of hydrogen. To cover the supply, we need H2 from many resources and because of its low density we need materials that can store bulky quantities of H2. Here we investigated the potential of a renewable source (waste wheat straw) to produce and store H2 through pyrolysis and adsorption. The impact of pressure and temperature (500–900 °C, and 1.01–30 bar range) on the selectivity of H2 rich gas production was systematically investigated; and …

An Extended Robust Optimisation Approach For Sustainable And Resilient Supply Chain Network Design: A Case Of Perishable Products, Seyed Ashkan Hosseini Shekarabi, Reza Kiani Mavi, Flavio Romero Macau

Research outputs 2022 to 2026

Disruptions and uncertainties pose considerable challenges in supply chain (SC) operations, requiring robust, strategic approaches. This study addresses financial resource allocation between supply chain network (SCN) design and external market investments, explicitly considering budget allocation and sales representative selection for perishable products. We propose a novel axis-shift robust (AxShR) method combined with an enhanced p-robust optimisation framework to manage multiple complex uncertainties. The model introduces a new resilience strategy allowing retailers to transfer products within the SCN, and apply artificial intelligence (AI) via a neural network to predict disruptions by evaluating risk indicators such as supplier location risk, raw material …

Integrated Genomic Analysis Of Nf1-Associated Peripheral Nerve Sheath Tumors: An Updated Biorepository Dataset, Jineta Banerjee, Yang Lyu, Kuangying Yang, Angela C Hirbe, Et Al.

2020-Current year OA Pubs

Neurofibromatosis type 1 (NF1) is an inherited neurocutaneous condition that predisposes to the development of peripheral nerve sheath tumors (PNST) including cutaneous neurofibromas (CNF), plexiform neurofibromas (PNF), atypical neurofibromatous neoplasms of uncertain biologic potential (ANNUBP), and malignant peripheral nerve sheath tumors (MPNST). The Johns Hopkins NF1 biospecimen repository promotes the successful advancement of therapeutic developments for NF1-associated PNST through acquisition and genomic analysis of human tumor specimens. RNA sequencing (RNAseq) and whole exome sequencing (WES) data were generated from 73 and 114 primary human tumor samples, respectively. These pre-processed data, standardized for immediate computational analysis, are accessible through the NF …

Targeting Triple-Negative Breast Cancer With Momordicine-I For Therapeutic Gain In Preclinical Models, Kousik Kesh, Ellen T Tran, Ruchi A Patel, Cynthia X Ma, Ratna B Ray

2020-Current year OA Pubs

No abstract provided.

The Ethics Of Mass Communication

Communication Research Trends

Recent years have seen an unprecedented uncertainty and debate over the ethics of mass media. James Thomson, curator of Nieman fellowships for journalists at Harvard University, detects in experienced journalists increasing doubt - even cynicism - regarding the morality of many accepted media practices. John Birt, associated with ITV in London, notes much more questioning of the morality of television programming in Britain.

One might expect the churches to help in clarifying issues of media ethics. The Catholic Church, for example, has a strong tradition of philosophical analysis of ethical problems. Yet, surprisingly, except in Spain, one finds little involvement …