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Empowering The User Through Inclusive Technical Writing, Robert Enriquez Aug 2025

Empowering The User Through Inclusive Technical Writing, Robert Enriquez

English Theses & Dissertations

This thesis examines the issues in technical writing due to a disconnect between writer and reader/user. I am basing this study on my real-life job. I am a manager at a well-known sneaker retailer. In August 2024, there was a Workforce Management (WFM) software that the sneaker retailer launched in the retail stores. The WFM itself was glitched and unfinished. Not much disclaimer, training or preparation was given other than these procedural documents the sneaker retailer gave. If all the store managers had to depend on was technical documentation to prepare for this already glitched WFM, then I argue there …


Reproductive Redlining: Unraveling Historical Disparities And Facility Placement In Distance To Licensed Childcare Facilities, Reproductive Health Clinics, & Crisis Pregnancy Centers For Women In The Southern Region Of The United States, Mackenzie A. Kibler Aug 2025

Reproductive Redlining: Unraveling Historical Disparities And Facility Placement In Distance To Licensed Childcare Facilities, Reproductive Health Clinics, & Crisis Pregnancy Centers For Women In The Southern Region Of The United States, Mackenzie A. Kibler

Sociology & Criminal Justice Theses & Dissertations

This dissertation investigates how historical and structural inequalities shape contemporary access to reproductive health services, licensed childcare facilities, and crisis pregnancy centers across Mississippi, Virginia, and Maryland. Using feminist geography, reproductive justice theory, and historical trauma theory, this research develops the concept of reproductive redlining to explore how race, policy, and space intersect to produce health disparities. By combining GIS mapping with multivariate statistical analysis and redlining data from the Home Owners’ Loan Corporation (HOLC), the study evaluates spatial distributions and demographic correlates of facility access before and after the Dobbs decision. Findings reveal enduring spatial inequities that disproportionately impact …


Predictors Of Healthcare Providers' Readiness For Health System Transformation In Saudi Arabia, Ahmed Ali Alasiri Aug 2025

Predictors Of Healthcare Providers' Readiness For Health System Transformation In Saudi Arabia, Ahmed Ali Alasiri

Health Services Research Dissertations

The healthcare system in Saudi Arabia is undergoing significant health reform to warrant sustainable welfare provision. Privatization or public-private partnerships (PPPs) were introduced in 2021 and outlined the vision for the health system for 2023. The planned initiatives aim to be comprehensive and effectively reach individuals and society, including citizens, noncitizens, and visitors. This dissertation seeks to study and explore privatization, the role of healthcare providers, and their capacity to adapt to the transformation of the healthcare system. To achieve this ambitious goal, several interrelated projects have been undertaken. The first project was a systematic review aimed at studying the …


Toward More Challenge-Engaging Stem Students: A Narrative Inquiry Into Student Persistence In The Face Of Failure, Stephanie R. Fahey Aug 2025

Toward More Challenge-Engaging Stem Students: A Narrative Inquiry Into Student Persistence In The Face Of Failure, Stephanie R. Fahey

Educational Leadership & Workforce Development Theses & Dissertations

Science, Technology, Engineering, and Mathematics (STEM) postsecondary graduates greatly contribute to advances in technology and research, and STEM fields promise graduates careers with positive long-term outcomes. Many postsecondary students initially choose STEM majors; however, less than half of those students graduate with a STEM degree. High STEM attrition is a problem that continues to vex educators and researchers. One attributable factor to high STEM attrition is students adversely reacting to initial academic failure in challenging STEM educational contexts. However, there are a lack of studies that investigate the individual experiences of students who persist despite academic failure to better understand …


Explanations For Racial Inequality In America; Effects Of Protestant Beliefs, Behaviors And Region, Qurshonda Shannae Lomans Aug 2025

Explanations For Racial Inequality In America; Effects Of Protestant Beliefs, Behaviors And Region, Qurshonda Shannae Lomans

Sociology & Criminal Justice Theses & Dissertations

The founder of the Center for the Study of Social Policy in Washington DC, Tom Joe (1987) released an article examining economic disparities between Black and White Americans. Across the measures of income, poverty and unemployment rates, Black Americans were found to be at an economic disadvantage. According to current data published by the U.S. Department of Commerce (2018), the economic wealth gap has remained unequal. Prior research examining racial inequality has found Protestantism to be a foundation from which Americans form their ideologies about social issues (Hunt, 2007; Edgell & Tranby, 2007; Taylor & Merino, 2011). Data provided by …


"Legitimacy, War, And The State: A Framework For Understanding Legitimation Strategies In Us Foreign Policy", Daniel Jose Palomino Aug 2025

"Legitimacy, War, And The State: A Framework For Understanding Legitimation Strategies In Us Foreign Policy", Daniel Jose Palomino

Graduate Program in International Studies Theses & Dissertations

Do social norms play a role in policy maker’s foreign policy choices? What methods or strategies are effective in generating sustainable public support? In contrast to certain theories that conceive of international relations as purely divorced from social norms – be they international or domestic - I argue that the characteristic of legitimacy is critical to understanding how states construct and pursue their foreign policy. Using a methodology of historical review I examine four primary qualities of legitimation theory: Concern, Audience, Effort, and Reception; using the test case of the Americanization of the Vietnam War (1961-1965) this study will …


Graduate Students’ Perspectives On Universal Design For Learning (Udl) 3.0 Guidelines: A Q-Methodology Study, Taylor C. Rodriguez Aug 2025

Graduate Students’ Perspectives On Universal Design For Learning (Udl) 3.0 Guidelines: A Q-Methodology Study, Taylor C. Rodriguez

Educational Leadership & Workforce Development Theses & Dissertations

The purpose of this study was to explore graduate students’ perspectives of Q-methodology to understand their insights on the newly updated Universal Design for Learning (UDL) 3.0 guidelines and how they feel these guidelines support their academic journey. A Q-sort instrument consisting of 36 statements aligned with UDL 3.0 principles was administered to graduate students at the master’s and doctoral levels. Thirty-two participants completed the Q-sort activity, and factor analysis revealed four distinct viewpoints reflecting varied perceptions of UDL’s relevance and impact within graduate education.

Findings indicate areas of consensus among students, particularly regarding the importance of developing student autonomy …


Input Structure Based Optimization For Privacy Preserving Ai Systems, Feng Yizhou Aug 2025

Input Structure Based Optimization For Privacy Preserving Ai Systems, Feng Yizhou

Electrical & Computer Engineering Theses & Dissertations

As Artificial Intelligence (AI) systems become increasingly integrated into critical domains, ensuring privacy-preserving model design and system deployment has become a pressing priority. Safeguarding both sensitive user data and proprietary model parameters is critical throughout the AI model and system, from data acquisition and pre-processing to model inference and deployment. However, existing privacy-preserving frameworks face several limitations, including fragmented data ownership, incomplete protection across system stages, substantial computational overhead, and poor scalability to modern architectures such as large language models. This dissertation explores a unifying optimization strategy centered on input structure design to address these challenges. The core idea is …


Peace Engagement And Non-Negotiable Commitment Through An In-Depth Lens [Pencil Theory]: A Film Perspective On Un’S Conflict Resolution, Edward Moses Sam Selvaraj Aug 2025

Peace Engagement And Non-Negotiable Commitment Through An In-Depth Lens [Pencil Theory]: A Film Perspective On Un’S Conflict Resolution, Edward Moses Sam Selvaraj

Graduate Program in International Studies Theses & Dissertations

The research addresses the effectiveness of the United Nations concerning conflict resolution and peacekeeping, seen from the perspective of film culture. Applying the "PENCIL Theory" (Peace Engagement through an in-depth lens), the UN study along with its structural dynamics would be considered herein: a pencil comprising the Security Council as its lead, world as the eraser, and filmmakers as the ferrule that is representative of that significant link between public awareness and policy impact, and the UN General Assembly and Secretariat as its body in support of the decision-making processes. It brings to the fore the critical impacts on the …


Multimedia Forensics: Identification And Verification Of Source Camera, Vehicle Speed Estimation, And Deepfakes Detection, Jiajun Jiang Aug 2025

Multimedia Forensics: Identification And Verification Of Source Camera, Vehicle Speed Estimation, And Deepfakes Detection, Jiajun Jiang

Electrical & Computer Engineering Theses & Dissertations

This dissertation advances multimedia forensics by addressing three critical research areas that enhance the authenticity verification and analysis of digital media. Multimedia forensics, which encompasses techniques for examining images, videos, audio, and text, faces increasing challenges due to sophisticated editing tools and massive data volumes. In the first study, a fast source camera identification and verification method based on PRNU analysis is proposed for video forensic investigations. By integrating camera rolling and I-frame analysis, this approach achieves a processing speed improvement of at least 15 times over conventional frame-by-frame methods while reducing false positives. The second study focuses on vehicular …


The Effects Of The Chief Information Officer’S Presence And Tenure On Financial Performance, Xuemei Li Aug 2025

The Effects Of The Chief Information Officer’S Presence And Tenure On Financial Performance, Xuemei Li

Theses and Dissertations in Business Administration

CIOs should be at the core of the organization. They play more and more critical roles in organizations. However, CIOs have not been paid enough attention in many firms. This can be partially observed in a lack of studies about CIOs, for instance, how CIOs influence the organizations, and how organizations' settings influence the CIOs. Technical initiatives or innovations may be the bridge between CIOs and firm performance. Different theories have been employed concerning CIOs, innovations, and firm performance. For instance, the resource-based view (RBV) has served as a theoretical foundation in related studies.

Drawing on RBV, attention-based view (ABV), …


Two Essays On Firms’ Reactions To Major Events In Rival Companies, Alireza Askarzadeh Aug 2025

Two Essays On Firms’ Reactions To Major Events In Rival Companies, Alireza Askarzadeh

Theses and Dissertations in Business Administration

The first essay of this dissertation examines the influence of peer credit rating downgrades on firms’ financial decisions. The results show that firms respond to a rival’s downgrade by increasing excess debt capacity, excess cash holdings, excess net working capital, and the excess cash conversion cycle. They also accelerate their speed of adjustment (SOA) toward target capital structures. These adjustments are motivated by a desire to mitigate the higher costs and risks associated with financial distress and to preserve competitive advantage. Moreover, firms with more capable managers, and those operating in environments with greater market competition, higher information asymmetry, and …


Practicing In The Laboratories Of Democracy: An Interpretive Phenomenological Analysis Of How Political Science Faculty Use Simulations With Community College Students, James Stewart Shifflett Aug 2025

Practicing In The Laboratories Of Democracy: An Interpretive Phenomenological Analysis Of How Political Science Faculty Use Simulations With Community College Students, James Stewart Shifflett

STEMPS Theses & Dissertations

Political science faculty members have often used simulations to promote civic engagement and build political efficacy in students. However, the use of political simulations with community college students has not been studied as extensively as it has with their four-year counterparts. Through the interpretive phenomenological analysis (IPA) methodology, this study examined the experiences of nine political science faculty members who use simulations with community college students to understand how instructional designers might better support their civic engagement and design efforts. Faculty members who participated in the study use simulations as constructive social interactions; as comprehensive learning experiences integrating preparation, facilitation …


“We Are Trans, But We’Re Not Transitional”: Exploring Safety, Place, And Space In The Lives Of Transgender Individuals In Southeastern Virginia, Susana Avalos Aug 2025

“We Are Trans, But We’Re Not Transitional”: Exploring Safety, Place, And Space In The Lives Of Transgender Individuals In Southeastern Virginia, Susana Avalos

Sociology & Criminal Justice Theses & Dissertations

In general, little research exists on trans people’s spatial experiences despite space being highly relevant to their experiences of violence and perceptions of safety. To date, two criminological studies have examined LGBTQ people’s fear of crime in relation to public or private places and spaces. This is in stark contrast to the sizable place and space literature on cisgender men and women. These topics from the perspectives of trans people are underexplored primarily because most criminological research has historically upheld binarized understandings of gender. Safety should not be privileged or limited to certain groups, individuals, or spaces. Instead, safety should …


Complex System Governance And Cyber Operations, Willie Gernard Mccallister Aug 2025

Complex System Governance And Cyber Operations, Willie Gernard Mccallister

Engineering Management & Systems Engineering Theses & Dissertations

This dissertation examines the potential integration of Complex System Governance (CSG) within cybersecurity, emphasizing the development of a reference model for Cybersecurity Infrastructures. Traditional strategies for securing digital environments have struggled to address the intricate and dynamic layers inherent in modern cybersecurity systems. The purpose of this research is to explore the applicability of CSG as a framework to assess cybersecurity infrastructure using a case study research design. The research addresses two key questions: (1) How can the CSG reference model be adapted to explore cybersecurity infrastructure? (2) What results from CSG based exploration of cybersecurity infrastructure through a case …


Exploring The Relationship Between Cannabis Use Motives And Readiness To Change Among Young Adult College Students, Emma Kathryn Rawls Aug 2025

Exploring The Relationship Between Cannabis Use Motives And Readiness To Change Among Young Adult College Students, Emma Kathryn Rawls

Psychology Theses & Dissertations

Cannabis use among young adult college students has risen steadily over the past decade, raising concerns about the associated health, academic, and psychological consequences. While cannabis use motives and readiness to change have each been linked to use patterns and outcomes, limited research has examined how these factors interact. The current study investigated whether readiness to change, based on the Transtheoretical Model (TTM), moderates the relationship between cannabis use motives and cannabis-related consequences as well as past-30-day use frequency. A sample of 100 college students 18-25 years old (Mage = 20.08, SD = 2.12; 67% female; 55.0% Black or …


Two Essays On The Role Of Anthropomorphism In Consumer Behavior, Faegheh (Faa) Taheran Aug 2025

Two Essays On The Role Of Anthropomorphism In Consumer Behavior, Faegheh (Faa) Taheran

Theses and Dissertations in Business Administration

The first essay of this dissertation investigates the contradictory findings on the relationship between anthropomorphism and self-control by focusing on how everyday anthropomorphized objects, rather than the products being used for consumption, influence consumer behavior. While previous studies have shown that using anthropomorphized products may decrease consumers’ self-control, this paper examines how unrelated [to consumption] anthropomorphized objects in a consumer’s environment—such as a water bottle with a humanlike face—can evoke a sense of social presence, increasing consumers’ perceptions that they are being negatively evaluated. Drawing on mind perception theory, I propose that this fear of negative evaluation can enhance self-control. …


Systems Statistical Engineering – Hierarchical Fuzzy Constraint Propagation, Hengameh Fakhravar Aug 2025

Systems Statistical Engineering – Hierarchical Fuzzy Constraint Propagation, Hengameh Fakhravar

Engineering Management & Systems Engineering Theses & Dissertations

Driven by the growing need in the 21st century for integrating rigorous statistical analysis into engineering research, there is a movement to develop an integrated statistical engineering science within statistics and quality communities (Hoerl & Snee, 2010; Anderson-Cook et al., 2012). Systems Statistical Engineering research seeks to integrate the Causal Bayesian hierarchical modeling (Pearl, 2009) and cybernetic control theory within Beer’s Viable System Model (1972, 1979, 1985) and the Complex Systems Governance framework (Keating, 2014; Keating & Katina, 2015, 2016) to produce multivariate systemic models for robust dynamic systems mission performance. Cotter & Quigley (2018) set forth the Bayesian systemic …


A Focused Ethnography: Mental Health Therapists In Pediatric Integrated Care, Melanie Agustin Aug 2025

A Focused Ethnography: Mental Health Therapists In Pediatric Integrated Care, Melanie Agustin

Counseling & Human Services Theses & Dissertations

The scope of practice for Licensed Professional Counselors (LPCs) and counseling residents (LPC-R) in integrated behavioral health (IBH) settings is grounded in accredited, theory-informed education and training. The benefits of IBH models are well-documented, however there is limited research that addresses how counselors develop professionally and clinically function, while navigating within pediatric inpatient environments. This qualitative dissertation used a focused ethnographic design to explore the lived experiences of ten purposively sampled counselors (n = 10) through demographic surveys, field observation, and semi-structured interviews. Reflexive journaling bracketed researcher bias, and thematic analysis, supported by NVivo and new member checking, guided interpretation. …


Intersecting Realities And Evolving Landscapes: Mapping Generative Ai Within The Framework Of Digital Rhetoric, Joshua Troy Nieubuurt Aug 2025

Intersecting Realities And Evolving Landscapes: Mapping Generative Ai Within The Framework Of Digital Rhetoric, Joshua Troy Nieubuurt

English Theses & Dissertations

The increased usage of [Generative] AI technologies (GenAI) in the 21st century has called into the question the rhetorical agency of these digital things. [Gen]AI has historically been framed within a Heideggerian “readiness-to-hand” dynamic in which it has been unilaterally conceived as a tool to be used by humans. This dissertation proposes that the GenAI assemblage is capable of being a co-actor in rhetorical spaces. To provide evidence for this stance This dissertation utilizes Actor Network Theory to map the actants within a GenAI assemblage. In doing so it allows for an understanding of the stakeholders (both human and non-human) …


Human Activity Recognition And Identification Driven Automated Deep Learning For Time-Series Classification, Justin Alan Gamble Aug 2025

Human Activity Recognition And Identification Driven Automated Deep Learning For Time-Series Classification, Justin Alan Gamble

Engineering Management & Systems Engineering Theses & Dissertations

The growing emphasis on Digital Engineering (DE) within the U.S. Department of Defense (DoD) demands advanced methods for leveraging vast time-series data generated by sensor-rich environments. Deep learning models offer promising solutions for complex timeseries classification tasks, however their design and optimization remain highly resource intensive, requiring specialized expertise. This dissertation addresses this challenge by developing and evaluating an Automated Machine Learning (AutoML) framework specifically tailored for the time-series classification task of Human Activity Recognition and Identification (HARI).

A systematic investigation was conducted using the Design Science Research Methodology (DSRM) comparing traditional search strategies of grid search and random search …


A Methodology For Model-Based Certification, Jay Albert Silverman Aug 2025

A Methodology For Model-Based Certification, Jay Albert Silverman

Engineering Management & Systems Engineering Theses & Dissertations

A need for a single source of knowledge for design decisions has led to the development of a new field of systems engineering, model-based systems engineering (MBSE) (Delligati, 2014). System certification is defined as affirming that regulatory requirements for a system have been met (Goodwin & Juzaitis, 2006). System certification is a specific application of system validation. System verification can be defined as ensuring that the system of interest (SOI), as designed, is in accordance with the design inputs/requirements. System validation can be defined as ensuring that the SOI, as designed, meets the defined system needs (Wolfgand, Katz, & Wheatcraft, …


Adaptations To Family-Based Treatment For Medicaid-Insured Adolescents With Anorexia Nervosa, Renee Borges Aug 2025

Adaptations To Family-Based Treatment For Medicaid-Insured Adolescents With Anorexia Nervosa, Renee Borges

Doctoral Dissertations

Background: Family-based treatment (FBT) is the leading intervention for adolescents with anorexia nervosa (AN), however it is under researched in socioeconomically disadvantaged and racially diverse youth.

Methods: Semi-structured interviews were completed with ten FBT clinicians who practice in publicly-funded settings. Interview questions were focused on implementation challenges, overall acceptability and appropriateness of FBT, and naturally-occurring treatment adaptations.

Results: Content analysis revealed common themes relating to the implementation of FBT in publicly-funded, community-based settings: acceptability and appropriateness, complexity and learnability, perceived core components of FBT, cultural adaptations, socioeconomic factors, logistical considerations, organizational and systemic barriers, training acceptability, participant’s self-efficacy, and telehealth …


Inclusion, Diversity, Equity, And Access Annual Report, Fiscal Year 2025, April Anderson-Zorn, Emily Baldoni, Karmine Beecroft, Chad E. Buckley, Susan Franzen, Tom Hardy, Ellie Harman, Laura Killingsworth, Heather Koopmans, Maddi Loiselle, Joshua Newport, Ryan Peters, Seth Peterson, Lindsey Skaggs, Caitlin Stewart, Maria Tudela, Eric Willey, Angela Yon Aug 2025

Inclusion, Diversity, Equity, And Access Annual Report, Fiscal Year 2025, April Anderson-Zorn, Emily Baldoni, Karmine Beecroft, Chad E. Buckley, Susan Franzen, Tom Hardy, Ellie Harman, Laura Killingsworth, Heather Koopmans, Maddi Loiselle, Joshua Newport, Ryan Peters, Seth Peterson, Lindsey Skaggs, Caitlin Stewart, Maria Tudela, Eric Willey, Angela Yon

Reports and White Papers - Milner Library

Report of Milner Library's activities and initiatives related to Inclusion, Diversity, Equity, and Access in Fiscal Year 2025. Compiled by the IDEA Committee.


Optimization Of Mhealth Behavioral Interventions For Patients With Chronic Lymphocytic Leukemia: The Health4cll Study, Che Young Lee, Max J Gordon, Melissa M Markofski, Emily C Lavoy, Susan K Peterson, Liang Li, Sara Fares, Miranda Baum, Margaret Pace, Danielle Walsh, Alessandra Ferrajoli, Karen Basen-Engquist Aug 2025

Optimization Of Mhealth Behavioral Interventions For Patients With Chronic Lymphocytic Leukemia: The Health4cll Study, Che Young Lee, Max J Gordon, Melissa M Markofski, Emily C Lavoy, Susan K Peterson, Liang Li, Sara Fares, Miranda Baum, Margaret Pace, Danielle Walsh, Alessandra Ferrajoli, Karen Basen-Engquist

Faculty, Staff and Student Publications

Purpose: This pilot study of a diet and physical activity intervention (HEALTH4CLL) was conducted to reduce fatigue and improve physical function (PF) in patients with chronic lymphocytic leukemia (CLL).

Methods: The HEALTH4CLL study used a randomized factorial design based on the multiphase optimization strategy (MOST). Patients received diet, exercise, and body weight management instructional materials plus a Fitbit and were randomized to undergo one of 16 combinations of 4 evidence-based mHealth intervention strategies over 16 weeks. Patients' fatigue, PF, health-related quality of life, behavior changes, and program satisfaction and retention were assessed. Paired t-tests were used to examine changes in …


Computed Tomography Radiomics-Based Cross-Sectional Detection Of Mandibular Osteoradionecrosis In Head And Neck Cancer Survivors, Serageldin Kamel, Laia Humbert-Vidan, Zaphanlene Kaffey, Sarah Mirbahaeddin, Abdulrahman Abusaif, David T A Fuentes, Kareem Wahid, Cem Dede, Mohamed A Naser, Renjie He, Ahmed W Moawad, Khaled M Elsayes, Melissa M Chen, Adegbenga O Otun, Jillian Rigert, Mark S Chambers, Andrew Hope, Erin Watson, Kristy K Brock, Katherine Hutcheson, Lisanne Van Dijk, Amy C Moreno, Stephen Y Lai, Clifton D Fuller, Abdallah S R Mohamed, Md Anderson Head And Neck Cancer Symptom Working Group Aug 2025

Computed Tomography Radiomics-Based Cross-Sectional Detection Of Mandibular Osteoradionecrosis In Head And Neck Cancer Survivors, Serageldin Kamel, Laia Humbert-Vidan, Zaphanlene Kaffey, Sarah Mirbahaeddin, Abdulrahman Abusaif, David T A Fuentes, Kareem Wahid, Cem Dede, Mohamed A Naser, Renjie He, Ahmed W Moawad, Khaled M Elsayes, Melissa M Chen, Adegbenga O Otun, Jillian Rigert, Mark S Chambers, Andrew Hope, Erin Watson, Kristy K Brock, Katherine Hutcheson, Lisanne Van Dijk, Amy C Moreno, Stephen Y Lai, Clifton D Fuller, Abdallah S R Mohamed, Md Anderson Head And Neck Cancer Symptom Working Group

Faculty, Staff and Student Publications

Purpose: This study aims to identify radiomic features from contrast-enhanced CT (CECT) scans that differentiate osteoradionecrosis (ORN) from normal mandibular bone in head and neck cancer (HNC) patients treated with radiotherapy (RT).

Materials and methods: CECT images from 150 patients with confirmed ORN diagnosis (2008-2018) at MD Anderson Cancer Center (MDACC) were analyzed (80 % train, 20 % test). Radiomic features were extracted using PyRadiomics from manually segmented ORN regions and automated contralateral healthy mandible regions. Correlation analysis (r > 0.95) reduced features for model training. A random Forest (RF) classifier with Recursive Feature Elimination identified discriminative features. Explainability was assessed …


Language Barriers In Accessing Healthcare Services For Refugees In The United States, Sadaf Khuram Aug 2025

Language Barriers In Accessing Healthcare Services For Refugees In The United States, Sadaf Khuram

Communication & Theatre Arts Theses

Accessing healthcare is a pivotal aspect of refugees' integration into their host countries and significantly impacts their long-term health outcomes. The literature emphasizes the critical role of language proficiency in overcoming communication barriers within healthcare settings. This thesis, however, challenges the assumption that addressing language barriers alone is universally sufficient. It argues that the importance of language solutions is context-dependent, varying with the design of healthcare systems and the diverse needs and backgrounds of refugees. In some cases, focusing primarily on language barriers can divert resources from other critical areas, particularly when healthcare facilities have limited capacities or when services …


The Inside Scoop: Elucidating The Three-Way Relationship Between Schistosoma Mansoni, The Gut, And Vaccines, Mariam A. Mhanna Aug 2025

The Inside Scoop: Elucidating The Three-Way Relationship Between Schistosoma Mansoni, The Gut, And Vaccines, Mariam A. Mhanna

Biomedical Sciences Theses & Dissertations

Schistosomiasis is a neglected tropical disease that affects over 250 million people worldwide. This blood fluke infection burdens communities and areas with limited to no access to clean fresh water. When a host is exposed to cercariae, the infectious agent, in a body of water, it matures in the host’s circulation into adult female and male worms. Copulated adult worms migrate to the mesentery, in the case of Schistosoma mansoni, and produce eggs that can cross the intestinal barrier and get excreted in the feces to continue the lifecycle. The effects of S. mansoni infection on the host …


Master Protocol Design With Hybrid Control For Efficient Early-Phase Trial Consolidation, Alexander M Kaizer, Xiaojiang Zhan, Eric Baron, Rui Sammi Tang, David S Hong, Brian P Hobbs Aug 2025

Master Protocol Design With Hybrid Control For Efficient Early-Phase Trial Consolidation, Alexander M Kaizer, Xiaojiang Zhan, Eric Baron, Rui Sammi Tang, David S Hong, Brian P Hobbs

Faculty, Staff and Student Publications

Purpose: Master protocols represent transformations, enabling multiple therapies or diseases under a single protocol. These designs streamline therapeutic development by reducing redundancies. Suited for evolving fields such as oncology and global emergencies such as the COVID-19 pandemic, master protocols have been exemplified by studies such as RECOVERY, Solidarity, and I-SPY 2, which accelerated effective treatment identification (with I-SPY 2 focused on molecular subtypes). Recent oncology examples, such as MORPHEUS, evaluate immunotherapy combinations with shared controls. Despite advantages, their application in early-phase oncology remains underutilized amid growing regulatory emphasis on randomization for robust evidence.

Methods: US Food and Drug Administration (FDA) …


Nanotechnology For Immuno-Oncology, Adam J Grippin, Daeyong Lee, Eileen E Parkes, Wen Jiang, Betty Y S Kim Aug 2025

Nanotechnology For Immuno-Oncology, Adam J Grippin, Daeyong Lee, Eileen E Parkes, Wen Jiang, Betty Y S Kim

Faculty, Staff and Student Publications

Although the first generation of cancer immunotherapeutics produced unprecedented improvements in clinical outcomes for individuals with cancer, novel strategies to increase treatment specificity, delivery efficiency and pharmacokinetics are still needed. In this Review, we describe the potential advantages and current limitations of nanomaterials for cancer immunotherapy and highlight rational uses of nanosystems to generate potent and durable antitumor immune responses. We close with a review of the current state of clinical development of nanomedicine for cancer immunotherapy.