Digital Commons Network^™

Bioinformatic Analysis Of Pogz Variants In Relation To White Sutton Syndrome, Hannah Rollins

Theses

White-Sutton syndrome (WHSUS) is a rare neurodevelopmental disorder caused by mutations in the Pogo Transposable Element with ZNF Domain (POGZ) gene, which encodes pogo-transposable element with ZNF domain, a chromatin regulator essential for proper mitotic progression and DNA repair. This study uses a bioinformatic framework to evaluate the structural and functional impact of missense mutations in the conserved amino acid region (positions 500–800) of the POGZ protein. Protein modeling, variant effect prediction, conservation analysis, and molecular dynamics simulations were employed to gain an understanding of the effects of POGZ missense mutations on protein structure and movement with specific emphasis on …

Fall 2025 Digsight, Southern Adventist University

DIGSIGHT - Institute of Archaeology Newsletter

Fall 2025 issue of the Archaeology newsletter DigSight. Features the article "Vessels in Time."

Feminist Scholarly Editing: A Provocation, Marlowe Daly-Galeano, Melissa J. Homestead, Claudia Stokes, Leila Walker

Publications and Research

This essay examines the feminist challenges posed by the protocols and history of scholarly editing. Prompted by the recent revival of bibliographical studies, the essay seeks to instigate a similar reconsideration of scholarly editing, bibliography’s counterpart in textual criticism. Scholarly editing has a vexed history with regard to women and gender: women writers were seldom the beneficiaries of editorial attention, but editors regularly used gendered metaphors to describe their work and often relied on the unacknowledged labor of women. This essay examines the history of sexism within the field of scholarly editing, illustrates the challenges and promises of editing women’s …

International Headache Society Evidence-Based Guidelines On The Use Of Non-Invasive Neuromodulation Devices For The Acute And Preventive Treatment Of Migraine, Hsiangkuo Yuan, Serena L. Orr, Mohammad A. M. Al-Karagholi, Messoud Ashina, Fred Cohen, Hans-Christoph Diener, David W. Dodick, Rigmor Højland Jensen, Michael J. Marmura, Daniele Martinelli, Manjit S. Matharu, Anja S. Petersen, Patricia Pozo-Rosich, Simona Sacco, Lucy Simmonds, Cristina Tassorelli, Stewart J. Tepper, Gisela M. Terwindt, Shuu-Jiun Wang, Jiunn-Tyng Yeh, Stephen D. Silberstein

Department of Jefferson Headache Center Papers and Presentations

ObjectiveTo develop evidence-based clinical practice guidelines for non-invasive neuromodulation devices in acute and preventive migraine treatment.MethodsA systematic review was conducted across six databases from 1946 to April 2025. Randomized controlled trials evaluating Food and Drug Administration-cleared or Conformité Européenne (CE)-marked non-invasive neuromodulation devices were included. The quality of evidence was assessed using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) methodology, and recommendations were developed through consensus following GRADE Evidence-to-Decision frameworks. The working group comprised 15 senior members and six junior members.ResultsFrom 1536 initial records, 15 studies met the inclusion criteria and were finally used to develop evidence-based recommendations. …

Data Set For Determining Causality Between Civic Engagement And Civic Agriculture, Dongkyu Kim, Mi-Son Kim, Allison Kaika

Datasets

This dataset includes opinion data from a phone and online survey for the Rio Grande Valley and an online survey.

District Vulnerability Index For Pakistan (Dvip): Harnessing Multisectoral Data To Inform Equitable Policy And Climate Action, Population Council

Climate and Environmental Changes

Pakistan’s highly heterogeneous population faces significant development challenges, including unequal resource distribution and disparities in access to services, which create varying levels of vulnerability across communities. While existing studies have primarily examined vulnerability through climate, economic, or other disaster lenses, they often overlook underlying structural and systemic factors. This study aims to address that gap by developing an index that incorporates domains of vulnerability typically underrepresented in analyses of Pakistan.

Genetic Entropy: A Critical Examination, Sarah Hunter

Science, Faith, and Origins

Genetic entropy is a hypothesis proposing that genomes deteriorate over time due to the gradual accumulation of slightly harmful mutations that natural selection cannot effectively remove. This paper explores the scientific debate surrounding this claim by examining differing perspectives on the theory of genetic entropy. Proponents of genetic entropy, such as John Sanford, argue that most mutations are deleterious and fall within a “near-neutral” range, allowing them to accumulate since their effects are too small for natural selection to detect. Evidence to support this claim includes Robert Carter and John Sanford’s research on the deterioration of the H1N1 viral genome …

Nsu Library Link - Fall 2025 - Volume 2.2, Nova Southeastern University

NSU Florida Link Newsletter

No abstract provided.

Colony Collapse Disorder And How To Mitigate Losses, Axl Taylor

Department of Entomology: Distance Master of Science Projects

What is Colony Collapse Disorder?

The Role of Varroa destructor in CCD

Viruses and Their Role in CCD

Effects of Nosema in CCD

Habitat Destruction/Nutrition and Its Effect on CCD

Pesticides and their effect on CCD

Mitigating Causes of CCD

Colony Behavior, Social Resilience, and Monitoring

Integrated Management Approaches

Conclusion

Insect Biodiversity Of Prairie Land Based On Prescribed Fire Plans In Central Iowa, Katelyn Rodriguez

Department of Entomology: Distance Master of Science Projects

Introduction

Insects play a crucial role in the prairie ecosystems by helping to maintain a healthy balance in various aspects of human life. They play vital roles in assisting with pest control, waste decomposition, and the pollination of plants and crops (The Nature Conservancy, 2021). Additionally, they can serve as indicators of an environment's health, such as nutrient cycling in water and soil formation in crop fields (The Nature Conservancy, 2021). Insect biodiversity is a crucial component in ensuring our environment is adequately cared for, and in turn, other aspects of life that rely on insect relationships.

In some states, …

Broadening Dementia Risk Models: Building On The 2024 Lancet Commission Report For A More Inclusive Global Framework, Cyprian Mostert, Chinedu Momoh, Andrea Winkler, Connor Mclaughlin, Harris Eyre, Mohamed Salama, Levi Muyela, Karen Blackmon, Zul Merali, Kirti Ranchod

Brain and Mind Institute

No abstract provided.

Compassionate Causation In The Domestic Violence Survivors Justice Act, Zoë Lewis Ewing

University of Chicago Law Review

This Comment evaluates the implementation of the Domestic Violence Survivors Justice Act (DVSJA), a New York law passed in 2019 to provide shortened sentencing ranges for domestic violence survivors convicted of crimes. It identifies an inconsistency in sentencing courts’ application of the law’s causation standard, which requires that a petitioner’s experience of domestic violence be a “significant contributing factor” to their criminal conduct. Some courts interpret the prong narrowly, while others apply a broad causation standard. This Comment argues that courts should opt for the latter approach and consider causation in the DVSJA satisfied if domestic violence was “sufficiently significant …

Studying Topic Evolution Based On Bertopic Model And Semantic Function, Jiabin Qu, Mengyang Wang

Journal of Scientific Information Research

[Purpose/significance] Topic evolution analysis can help researchers quickly grasp the research hotspots and development trends of a discipline. However, existing topic models often overlook the semantic functions and structures of texts during topic extraction, making it difficult to reveal the deeper patterns of disciplinary development. This paper proposes an integrated framework for topic evolution analysis that combines the BERTopic model with semantic functions, aiming to enrich and improve the methodological system of topic evolution research.

[Method/process] Firstly, the BERTopic model is used to extract topics, obtaining the“Topic-Word”distribution. Next, a discourse parsing tool analyzes abstracts into five semantic function segments, resulting …

Research On Identification And Evaluation Method Of Medical Experts' Expertise Domains In Online Health Community Based On Knowledge Graph, Yunjiang Xi, Qian Zhang, Man Li, Juan Yu

Journal of Scientific Information Research

[Purpose/significance] This study aims to identify the expertise domains of medical experts, and evaluates their domain levels to provide a basis for community expert recommendation.

[Method/process] This study utilized the improved OneRel model to structure community historical Q&A into entity relation triples. Then used the knowledge graph triples to test the consistency between the medical knowledge in the community Q&A and the domain knowledge, and finally obtained the doctor's domain levels by aggregating in each expertise domain.

[Result/conclusion] Using the data example from xywy.com website, 214 doctors in the community were ranked in terms of their average level of expertise …

Identifying Key Influencing Factors Of Elderly Health Information Search Based On Meta-Ethnography, Zhumei Sun, Zhibing Wang

Journal of Scientific Information Research

[Purpose/significance] Health information search is an important way for elderly people to actively cope with aging. Identifying the key factors affecting of their health information searching and exploring the correlation among these factors are of positive significance for promoting the elderly proactive health ability.

[Method/process] This paper firstly integrated the original research through a meta-ethnographic approach to form a set of factors influencing the elderly health information search. The DEMATEL method was then used to analyze the interrelationships among the influencing factors and identify the key influencing factors.

[Result/conclusion] The study finds that, the influencing factors of elderly health information …

Application And Reflection Of Full-Text Bibliometric From The Perspective Of Knowledge Innovation:A Review Of The 2024 Academic Salon On Full-Text Bibliometric Analysis, Haichen Zhou, Chengzhi Zhang, Shuo Xu, Jin Mao

Journal of Scientific Information Research

[Purpose/significance] In December 2024, the 7th Chengdu Conference on Scientometrics & Evaluation was held in Chengdu. This article was conducted to summarize the salon on Full-text Bibliometric analysis of the forum, and reveal the research status and development trends of full-text bibliometric from the perspective of knowledge innovation, providing inspiration for future.

[Method/process] The article systematically summarizes and analyzes the presentations and discussions from the salon, exploring the theoretical foundation, application scenarios, and discussions of full-text bibliometric from the perspective of knowledge innovation.

[Results/conclusion] Full-text Bibliometric can reveal the micro-processes and underlying mechanisms of knowledge innovation, offering new insights and …

Reform And Exploration Of Talent Cultivation In Public Security Intelligence, Lei Hong, Guangliang Gao

Journal of Scientific Information Research

[Purpose/significance] Public security intelligence work has undergone a significant transformation from passive defense to proactive early warning, with corresponding shifts in its core functions. The cultivation of public security intelligence talents rooted in practical combat has evolved alongside the development of intelligence work, necessitating a clear understanding of its historical development and future prospects.

[Method/process] By employing a comprehensive approach that integrates literature analysis, data interpretation, and historical examination, this study systematically reviews the evolution of public security intelligence education from the perspectives of practical intelligence work, the overarching public security education system, and the specific aspects of intelligence education.It …

The Multidimensional Quantitative Evaluation Of Local Policies For Promoting The Development Of New Quality Productive Forces: Based On The "Theme-Tool-Effectiveness" Framework, Jing Pan, Hongjun Yi, Yu Lu

Journal of Scientific Information Research

[Purpose/significance] The development of new quality productive forces is a crucial strategic goal for national progress, with local policies serving as important conduits for conveying and implementing national strategies. Researching local policies that promote the development of new quality productive forces is significant for the implementation of the national strategy in different regions and for further policy evaluation.

[Method/process] By constructing a theme-tool-effectiveness analysis framework and employing LDA topic model, policy tools, and PMC index model, this study conducts a multidimensional quantitative evaluation of local policy texts related to the development of new quality productive forces.

[Result/conclusion] The study finds …

Disclosure Puzzles In Patent Law, Jonathan S. Masur, Lisa Larrimore Ouellette

University of Chicago Law Review

Since its inception, patent law has required that inventors publicly disclose information about their inventions in exchange for receiving patent rights. This foundational requirement is policed through multiple doctrines: patents fail “enablement” if “undue experimentation” is needed to practice the invention, and they lack adequate “written description” when they fail to establish the inventor’s “possession” of the invention.

Despite disclosure doctrines’ centrality, fundamental puzzles about their application remain unresolved. What are the boundaries between enablement and written description? Do equivalents claimed via the doctrine of equivalents have to be enabled or described? Are the rules different for after-arising technologies? Federal …

Your Consolation Brings Joy: How Private School Employees Support Students Experiencing Trauma, Virginia L. Rose

PhD in Education

Trauma caused by adverse childhood experiences is a growing and pervasive issue. Researchers have found trauma may have physical, emotional, behavioral, academic, and spiritual effects on children. School employees are in a unique position to teach students about resiliency and can mitigate the effects of traumatic stress. Although multiple studies have examined teachers’ definition, perspective, and experiences of trauma, few studies have taken place in faith-based schools. The following qualitative study used a phenomenological approach to discover the lived experiences of faith-based school employees in identifying and supporting students who have experienced trauma. Eleven faith-based school employees participated in a …

Effects Of Musical Participation On Senior Adult Musicians' Quality Of Life, M. Seth Mcgee

PhD in Education

As the global population of senior adults expands, so does the need for research-based strategies for maintaining health and well-being in this growing demographic. Current research has shown that musical involvement can provide benefits for senior adults’ physical health, cognitive function, emotional well-being, and sense of social connection. This study followed six senior adult musicians aged 60-82 who engaged in weekly musical activities in both individual and group contexts and examined their perceptions of how their daily participation in music-making affected their health and well-being. Participants were observed by the researcher interacting during rehearsals within the context of an active …

Arthurian Mock Epistolary, Connor P. Underwood

Arthurian Epistolary Project (HUM 270-001)

King Arthur’s Proclamation to the Britons Concerning “King” Rion

Arthurian Mock Epistolary, Claire Haupt

Arthurian Epistolary Project (HUM 270-001)

King Arthur Pardons Sir Lancelot

T.B. Boyd, James Scholz

Tennessee State University Notable Alumni

No abstract provided.

Closing The Loop On Textile Waste: Policy, Technology, And Consumer Behavior In Sustainable Fashion, Anthony Amotoe-Bondzie

Collected Student Papers

Textile waste has become one of the most visible consequences of the fashion industry’s linear production and consumption model, where materials are rapidly extracted, transformed, consumed, and discarded. This paper critically examines how sustainable fashion can move beyond isolated recycling efforts toward a more integrated circular economy framework. Rather than treating textile waste as only an end-of-life problem, the study analyzes it as a systems issue shaped by overproduction, weak product design, limited recovery infrastructure, fragmented regulation, and consumer habits that normalize short garment lifespans. The paper argues that closing the loop on textile waste requires coordinated interventions across policy, …

Oer Action Plan At Southern University And A&M College, Maletta Payne

Southern University and A&M College: John B. Cade Library Publications

This OER Action Plan, developed by the Southern University Library, outlines strategic initiatives to expand the adoption and integration of Open Educational Resources (OER) across a wider range of academic programs. The plan emphasizes building sustainable collaborations with faculty and academic departments, engaging administrative leaders to support OER through institutional policies and incentives, and aligning these efforts with the University’s mission to reduce student costs, foster teaching innovation, and enhance learning outcomes. Through targeted outreach, faculty development opportunities, and cross-campus partnerships, the plan aims to increase the visibility, use, and long-term impact of OER. This action plan was created as …

Advancing The Science Of Genomic Learning Healthcare Systems., Teri A Manolio, Renee Rider, Carol J Bult, Rex L Chisholm, Patricia A Deverka, Geoffrey S Ginsburg, Eric D Green, Gail P Jarvik, George A Mensah, Jahnavi Narula, Erin M Ramos, Mary V Relling, Dan M Roden, Robb Rowley, Noura S Abul-Husn, Adam H Buchanan, Christopher G Chute, Guilherme Del Fiol, Gai Elhanan, Susanne B Haga, Rizwan Hamid, Carol R Horowitz, Peter J Hulick, Cynthia A James, Janina M Jeff, Bruce Korf, Latrice Landry, Deven Mcgraw, Howard L Mcleod, Nancy J Mendelsohn, Travis Osterman, Casey Overby Taylor, Daryl Pritchard, Heidi L Rehm, Krystal S Tsosie, Jason L Vassy, Karriem Watson, Ken Wiley, Marc S Williams

Faculty Research 2025

INTRODUCTION: Identifying key characteristics of exemplar genomic learning healthcare systems (gLHS) and knowledge gaps that can be explored by collaboration among them is likely to accelerate the sharing of best practices and generation of evidence that informs the use of genomics in clinical care.

METHODS: Deliberations of an expert group convened by the National Human Genome Research Institute (NHGRI) supplemented by relevant literature.

RESULTS: Recent advances in genomic data standardization, automated clinical decision support, increased interoperability, and improved genomic technologies have enabled the development of several robust gLHS. They remain concentrated in major academic centers, however, and operate largely independently. …

Evaluation Of Hippocampal Dlgap2 Overexpression On Cognition, Synaptic Function, And Dendritic Spine Structure In A Translationally Relevant Ad Mouse Model., Andrew R Ouellette, Kristen M S O'Connell, Catherine Kaczorowski

Faculty Research 2025

INTRODUCTION: Developing effective therapeutics for Alzheimer's disease (AD) requires a better understanding of the molecular drivers of the disease. Our previous work nominated DLGAP2 as a modifier of age-related cognitive decline and risk for AD. We tested the hypothesis that overexpression of DLGAP2 in the hippocampus would protect against cognitive and synaptic deficits in a susceptible F1 5XFAD model.

METHODS: DLGAP2 was overexpressed in the hippocampus of F1 hybrid 5XFAD and non-transgenic littermates using a viral approach. Cognitive function, electrophysiological properties, and dendritic spine morphology were assessed at 6 and 14 months of age.

RESULTS: DLGAP2 overexpression impaired synaptic plasticity …

Expanding And Refining The Mammalian Phenotype Ontology To Enhance Disease Model Discovery., Susan M. Bello, Anna V Anagnostopoulos, Leigh Carmody, Nicolas Matentzoglu, Cynthia Smith

Faculty Research 2025

The mouse is a premier model system for investigating gene function and modeling human disease. For almost 40 years, Mouse Genome Informatics has worked to capture and integrate the data generated from mouse studies. A critical component of this integration is the development and use of the Mammalian Phenotype (MP) Ontology to capture the morphological and physiological effects of alterations to gene function in the mouse. As the wealth of phenotype data captured using the MP has expanded, its utility in the diagnosis of human disease has increased. Tools have been developed to use mouse and human phenotypes in variant …

Destin V. Dist. Ct. (Handwerker-Lamaster), 141 Nev. Adv. Op. 42 (Aug. 28, 2025), David Elder

Nevada Supreme Court Summaries

No abstract provided.