Digital Commons Network^™

Biliverdin Reductase A Is A Major Determinant Of Protective Nrf2 Signaling, Chirag Vasavda, Ruchita Kothari, Navneet Ammal Kaidery, Suwarna Chakraborty, Sunil Jamuna Tripathi, Ryan S Dhindsa, Cristina Ricco, Shruthi Shanmukha, Samaneh Saberi, Julia E Lefler, Priyanka Kothari, Kalyani Chaubey, Adele M Snowman, Michael C Ostrowski, Eugenio Barone, Lakshminarayan M Iyer, L Aravind, Sudarshana M Sharma, Andrew A Pieper, Bobby Thomas, Solomon H Snyder, Bindu D Paul

Duncan NRI Faculty and Staff Publications

Biliverdin reductase A (BVRA), the terminal enzyme in heme catabolism, generates the neuroprotective and lipophilic antioxidant bilirubin. Here, we identify a nonenzymatic role for BVRA in redox regulation. Through phylogenetic, genetic, biochemical, and enzymatic assays, we found that BVRA exerts critical nonenzymatic antioxidant activity. Transcriptomic analyses further revealed that BVRA physically and genetically interacts with nuclear factor erythroid-derived factor-like 2 (NRF2), a major transcriptional regulator of cellular redox signaling. ChIP-seq and RNA-seq analyses reveal that BVRA and NRF2 coordinate the expression of antioxidant genes, many of which are typically dysregulated in neurodegenerative conditions such as Alzheimer's disease. Thus, this noncanonical …

Efficacy Of Erdafitinib Before Or After Enfortumab Vedotin In Fgfr3-Altered Advanced Urothelial Cancer: Analysis Of The Unite Collaborative Study, Cindy Y Jiang, Hyunsoo Hwang, Ilana Y Epstein, Dimitra Rafailia Bakaloudi, Rafee Talukder, Amy K Taylor, Amanda Nizam, Tanya Jindal, Michael J Glover, Ali Raza Khaki, Pedro C Barata, Charles B Nguyen, Eugene Oh, Nancy B Davis, Hannah Mabey, Christopher J Hoimes, Sean T Evans, Bashar Abuqayas, Emily Lemke, Irene Tsung, Wei Qiao, Deepak Kilari, Yousef Zakharia, Mehmet A Bilen, Matthew I Milowsky, Sumit A Shah, Shilpa Gupta, Hamid Emamekhoo, Joaquim Bellmunt, Ajjai S Alva, Petros Grivas, Pavlos Msaouel, Vadim S Koshkin, Matthew T Campbell, Omar Alhalabi

Faculty, Staff and Students Publications

Background: Erdafitinib is approved for locally advanced/metastatic urothelial cancer (LA/mUC). As enfortumab vedotin (EV) plus pembrolizumab enters frontline management, outcomes with erdafitinib pre- and post-EV are clinically relevant but not specifically evaluated in clinical trials.

Methods: UNITE is a multi-institutional retrospective study of patients with LA/mUC treated with novel targeted agents. All patients with FGFR3 alterations treated with EV only, erdafitinib then EV (Erda->EV), and EV then erdafitinib (EV->Erda) were included. Sequential treatment with EV and Erda was not required. Primary endpoints were observed response rates (ORR) and progression-free survival (PFS); secondary endpoint was overall survival (OS).

Results: …

The Latest In Resuscitation Research: Highlights From The 2024 American Heart Association's Resuscitation Science Symposium, Gabriela M Galli, Aarthi Kaviyarasu, Sachin Agarwal, Catherine R Counts, Tommaso Scquizzato, Betty Yang, Clark G Owyang, Ryan Coute, Simon Orlob, Lindsay Shepard, Saleem Halablab, James Horowitz, Sarah Perman, Ryan Morgan, Anne Grossestreuer, Jacob Vine, Nicholas Johnson, Luke Andrea, Ari Moskowitz, Benjamin Abella, Cameron Dezfulian, Walid H Farooqi, Felipe Teran

Faculty, Staff and Students Publications

No abstract provided.

Ainr: Automated Intrinsic Non-Rigid Registration For Accuracy Qualification Of Complex Freeform Products In 3d Printing, Weizhi Lin, Qiang Huang

Faculty Research, Scholarly, and Creative Activity

Non-rigid shape registration identifies the optimal non-rigid transformation between an actual product and its intended design to characterize their geometric dissimilarities. This transformation is usually determined by iteratively minimizing point-wise distances to match points with point-wise rigid motion. However, freeform products may exhibit complex spatial patterns of shape deviation, leading to premature iteration termination due to tradeoffs among local regions. One solution is to segment the complex design into semantic features and perform segment-wise rigid registration. Segment boundaries are typically placed along high-curvature regions, where deviations are more likely occur in 3D printing. However, since boundaries are generally more prone …

A Sovereign Advisory System For Canada: Rebuilding Strategic Foresight In Trade And Innovation, Barry Appleton

Articles & Chapters

No abstract provided.

Phosphorylation Of Ryr1 At Ser2902 Decreases Ca2+ Leak In Skeletal Muscle And Susceptibility To Malignant Hyperthermia And Heat Stroke, Rachel Sue Zhen Yee, Chang Seok Lee, Ting Chang, Sung Yun Jung, Omar Yousif, Courtney Cavazos, John Colyer, Filip Van Petegem, George G Rodney, Susan L Hamilton

Faculty, Staff and Students Publications

The ryanodine receptor 1 (RYR1) is the sarcoplasmic reticulum (SR) Ca2+ release channel required for both skeletal muscle contraction and Ca2+ leak. Mutations in RYR1 cause malignant hyperthermia susceptibility (MHS) and enhanced sensitivity to heat stroke (ESHS), which can result in death due to excessive skeletal muscle thermogenesis upon exposure to volatile anesthetics or heat. Here, we investigated the molecular and physiological functions of phosphorylation of RYR1 at Ser2902 by the kinase SPEG (striated muscle preferentially expressed protein). Muscle from SPEG-deficient mice expressing RYR1 with a Ser2902 →Asp2902 (S2902D) point mutation to mimic phosphorylation by SPEG showed decreased SR Ca2+ …

Genetics-Nutrition Interactions Control Diurnal Enhancer-Promoter Dynamics And Liver Lipid Metabolism, Dishu Zhou, Ying Chen, Panpan Liu, Kun Zhu, Juliet Holder-Haynes, S Julie-Ann Lloyd, Cam Mong La, Inna I Astapova, Seunghee Choa, Ying Xiong, Hosung Bae, Marlene Aguilar, Hongyuan Yang, Yu A An, Zheng Sun, Mark A Herman, Xia Gao, Liming Pei, Cholsoon Jang, Joshua D Rabinowitz, Samer G Mattar, Yongyou Zhang, Dongyin Guan

Faculty, Staff and Student Publications

The circadian clock controls 24-h rhythmic processes. However, how genetic variations outside clock genes impact peripheral diurnal rhythms remains largely unknown. Here, we find that genetic variation contributes to different diurnal patterns of hepatic gene expression in both humans and mice. Nutritional challenges alter the rhythmicity of gene expression in mouse liver in a strain-specific manner. Remarkably, genetics and nutrition interdependently control more than 80% of rhythmic gene and enhancer-promoter interactions (E-PIs), with a noncanonical clock regulator, estrogen-related receptor gamma (ESRRγ), emerging as a top transcription factor during motif mining. Knockout of Esrrγ abolishes strain-specific metabolic processes in response to …

Estimated Waste Generation From 1 Million Basic Metabolic Panels: A Multisite U.S. Study, Seema Khattri Bhandari, Kwaku Twum, Erving T Laryea, Yaqing Du, Raeshun T Glover, Rachel G Brackbill, William Butler, Khushbu Patel, Christopher W Farnsworth, Christina C Pierre, Steven W Cotten, Joesph R Wiencek

2020-Current year OA Pubs

OBJECTIVES: Clinical laboratory operations consume large amounts of electricity and water and generate considerable quantities of solid waste. In this study, we quantified and compared the estimated solid waste produced from performing one million basic metabolic panels (BMPs) across five major high-throughput chemistry analyzer systems commonly used in the United States. Additionally, we estimated the carbon emissions associated with the electricity and water usage of each analyzer to better understand their environmental impact.

METHODS: Five academic medical centers each using a different clinical chemistry analyzer system, collected their respective annual vendor purchase data (January 2022-December 2022). Consumables including reagent cartridges, …

Fate Mapping Of Peripherally-Derived Macrophages After Traumatic Brain Injury In Mice Reveals A Long-Lasting Population With A Distinct Transcriptomic Signature, Maria Serena Paladini, Benjamin A Yang, Kristof A Torkenczy, Elma S Frias, Xi Feng, Karen Krukowski, Rene Sit, Maurizio Morri, Wendy Lam, Valentina Pedoia, Stefka Tyanova, Marco Colonna, Amber L Nolan, Susanna Rosi

2020-Current year OA Pubs

Traumatic brain injury (TBI) is an environmental risk factor for dementia and long-term neurological deficits, posing a significant public health challenge. TBI-induced neuroinflammation involves both brain-resident microglia and peripheral monocyte-derived macrophages (MDMs). Previous research has shown that MDMs contribute to the development of long-term memory deficits, yet their long-term behavior following brain infiltration remains unclear. To address this, our study uses two complementary fate-mapping mouse lines, CCR2-creERT2 and Ms4a3-cre, for precise and lasting tracking of MDMs in vivo. Here we show that MDMs persist in the brain for at least 8 months post-TBI in both male and female mice. MDMs …

Scientific Authority In The Public Sphere: The Heroic Legacies Of Carl Sagan And Philip Zimbardo, Scott T. Allison

Heroism Science

This article examines the parallel trajectories of Carl Sagan and Philip Zimbardo as scientists who assumed the role of public intellectuals. Their careers highlighted the tensions and opportunities inherent in bridging scholarly research and public engagement. Sagan, an astronomer, popularized the cosmic perspective to promote planetary stewardship, while Zimbardo, a social psychologist, used compelling methodologies to explore the psychological underpinnings of cruelty and heroism. Both were, in their own ways, heroic in their commitment to making science accessible, employing storytelling and mass media to render complex concepts understandable and relevant, thereby expanding the societal relevance of their disciplines. However, their …

Revisiting Least Restrictive Environment In Adapted Physical Education: A Framework For Evidence-Based Practice, Dillon R. Martinez, Samantha Charron

Essays in Education

This article addresses the implementation of Least Restrictive Environment (LRE) principles in adapted physical education. Despite the legal mandates established by the Individuals with Disabilities Education Act, the field faces significant challenges, including a shortage of qualified professionals, overemphasis on universal inclusion, and the exclusion of student voices from placement decisions. Through analysis of historical context, implementation challenges, and a proposed Student-Centered APE Placement Model (SCAPM), this article provides a preliminary framework for making evidence-based placement decisions that prioritize student success. By integrating perspectives from a preservice teacher education candidate and current higher education practice, the framework offers practitioners a …

Film Review: Marginal Voices In Taare Zameen Par, Ritwika Laskar

Journal of International Women's Studies

No abstract provided.

Film Review: A Feminist Critique Of The Representation Of Women In 21st-Century Bollywood Sports Biopics, Amitabh Roy

Journal of International Women's Studies

This review critically analyses the portrayal of women in Bollywood sports biopics using a feminist perspective, with reference to three influential 21st-century films: Mary Kom (2014), Saina (2021), and Shabaash Mithu (2022). While these movies ostensibly celebrate women’s sporting achievements, a close reading discloses the durability of patriarchal currents in the narrative, visual composition, and character construction. Using feminist theories like Laura Mulvey’s “male gaze,” Judith Butler’s “gender performativity,” and bell hooks’s intersectionality, this work contends that these films simultaneously empower and limit their heroines. Exploring how femininity, family, and national pride are performed in these films, this review examines …

Between Mothers And Daughters: Female Isolation, Despotism And Fragile Bonds In Anthony Trollope’S "Castle Richmond" And "Lady Anna", Aleksandra Tryniecka

Journal of International Women's Studies

Analyzing the dialogue in Anthony Trollope’s nineteenth-century novels Castle Richmond and Lady Anna reveals portrayals of mother-daughter conflicts that span throughout generations and carry profound societal consequences. In both novels, the mothers are depicted as ambivalent figures who simultaneously play the roles of both victim and oppressor. Relentlessly striving to redeem their past, the despotic mothers intimidate their daughters into accepting socially beneficial marriage arrangements. Using Bakhtin’s notion of dialogism, I present how in both novels, the younger generation (the daughters) adopt a fresh system of social values, which gradually results in a change in Victorian society of the second …

Evaluating Gender Policy In Kazakhstan: A Dual Perspective On Politics And Economics, Elmira Kagazbaeva, Ulzhan Kazybekova, Madina Axakalova

Journal of International Women's Studies

This article aims to advance gender studies in Kazakhstan by examining the underlying causes of inequality in the political and economic spheres. It holds both scientific and practical significance in identifying the challenges to gender equality in Kazakhstan and exploring potential solutions that could be applicable to other countries. The methodological framework of the study is grounded in a gender-based approach, complemented by general scientific and specialized methods of inquiry, including structural, functional, and content analysis of official documents. The research is supported by an analysis of official statistics and the legal framework governing gender-related issues. Kazakhstan’s gender policy is …

Antecedents And Measures Of Women’S Financial Empowerment: A Comprehensive And Global Literature Review, Priya Gupta, Mamta Aggarwal, Meera Bamba

Journal of International Women's Studies

Women’s financial empowerment has garnered greater interest in recent years, and numerous articles have highlighted gender disparities. In existing literature, antecedents and measures of economic empowerment are fragmented, with limited research that provides a comprehensive assessment framework. This systematic review aims to identify the determinants affecting women’s financial empowerment to develop a comprehensive framework to measure financial empowerment based on insights derived from an examination of 101 selected research articles published from 2001 to 2023 and exclusively sourced from the Scopus database. The search followed a comprehensive and systematic approach involving identification, selection, appraisal, and synthesis of the existing literature. …

Pindi Boys: The Cultural Production Of Urban Masculinity In Rawalpindi, Pakistan, Saad Ali Khan

Journal of International Women's Studies

This article seeks to understand and analyze the formation of urban masculinities in Rawalpindi, Pakistan by focusing on a subculture known as “Pindi boys,” who are young men aged 17-22. In doing so, this research offers an understanding of what it means to be a teen or young man from a low-income household in the urban city of Rawalpindi. How does sociocultural context influence boys and young men to embody a specific type of masculinity? Following the daily lifestyle of Pindi boys, this research avoids generalizations that result in an ahistorical analysis of men and masculinities in urban spaces. Considering …

Patterns And Levels Of Use Of Google Apps For Education By Faculty Members At The University Of Bisha And Their Perceptions Of The Availability Of Conditions That Facilitate Sustainability Of Their Use In The Light Of Eli’S Model Of Change., Mohammed Ayid Alqahtani

University of Bisha Journal for Educational Sciences

This study aimed to reveal the current patterns and levels of use of Google Apps for Education by faculty members at the University of Bisha, along with their perceptions of the factors that facilitate their use in light of Eli’s model. To achieve this goal, the study employed a descriptive method, and a questionnaire was designed and administered to all members of the study community, which included 950 male and female faculty members in the second semester of the academic year 1443/1444 AH. A total of 280 of them, constituting 30% of the study population, responded. The study found that …

Keys For Success When Using An Integrative Interprofessional Teaching Model: A Synergistic Approach, Hon-Vu Quang Duong, Nina Marcellus, Sandip Thanki

Journal of Educational Research and Practice

This study presents a longitudinal analysis of the qualitative experiences and quantitative outcomes associated with integrative, interdisciplinary teaching in the context of a specific nursing course, Pathophysiology (NURS 337), at a public, 4-year, state college (now university). Spanning an 8-year period, from 2014–2022, the research compares two distinct student cohorts: one exposed to collaborative interdisciplinary teaching methods, the other to traditional non-collaborative instructional approaches. The findings reveal that integrative, interdisciplinary teaching yielded significant benefits across multiple metrics. Notably, integrative, interdisciplinary teaching contributed to a more normalized distribution of grades, higher student retention rates, and an elevated cumulative GPA at the …

Positive Education And Student Success In College: An Overview And Practical Implications, Lin L. Agler, Saurabh Gupta

Journal of Educational Research and Practice

Institutions of higher education are facing a historically challenging time as student graduation and retention rates continue to be less than ideal, especially since the start of the COVID-19 pandemic. This is a critical time of transition for the competitive structure of higher learning, as finances, technology, student success, and institutional rankings all have a joint leading position in this structure. Applying concepts of positive psychology to higher education has been shown to be advantageous for student success and retention. This strengths-based approach helps institutions remain innovative and competitive. However, instructors face a great challenge in effectively applying positive psychology …

The Reality Of Using Authentic Assessment In Public Education In Saudi Arabia From The Teachers’ Perspective, Huda Homydan Atyan Almehmadi

University of Bisha Journal for Educational Sciences

The study aimed to identify the reality of using authentic assessment in general education in the Kingdom of Saudi Arabia from the perspectives of teachers. It also aimed to determine the impact of variables such as gender, educational qualification, teaching stage, and teaching experience. To achieve the objectives of the study, a questionnaire was designed, and it was administered to a convenient random sample of (298) teachers in the general education sector in Makkah. The study's results revealed that the employment of authentic assessment strategies scored a high degree of implementation in all areas, with an average score of (4.1), …

The Reality Of Employing Artificial Intelligence Applications By Mathematics Teachers In The Educational Process In Medinah, Salwa Salem Hamzah Barzanji

University of Bisha Journal for Educational Sciences

The study aimed to reveal the reality of mathematics teachers’ use of artificial intelligence applications in the educational process. To achieve this, the researcher designed a questionnaire consisting of (26) statements; Distributed into three main axes, the study was applied to (315) mathematics teachers in the general education stages. The results revealed that the degree of mathematics teachers’ knowledge of the importance of employing artificial intelligence applications in the educational process; was high, while the degree of mathematics teachers’ use of artificial intelligence applications in the educational process was low, and the challenges facing mathematics teachers in employing artificial intelligence …

The Impact Of A Proposed Training Program Based On Flipped Learning To Develop Scientific Research Skills For Graduate Applications At King Khalid University, Badria Saad

University of Bisha Journal for Educational Sciences

Abstract: The research aimed to reveal the impact of a proposed training program based on flipped learning and its impact on the development of scientific research skills for graduate students at the College of Education, King Khalid University from the point of view of faculty members in Saudi universities, where the sample consisted of faculty members in the faculties of education in some Saudi universities of (24) faculty members, to determine the skills of scientific research in the Delphi style, and the sample of graduate students at the master's and doctoral stages at the College of Education, King Khalid University, …

The Educational Role Of Islamic Studies Teachers In Saudi Arabia In Developing Their Students' Awareness Of Combating Electronic Terrorism, Abdurazaq Owaied Athmali

University of Bisha Journal for Educational Sciences

The aim of the current research is to identify the educational role of teachers of Islamic studies in the Kingdom of Saudi Arabia in developing students' awareness of combating electronic terrorism, in addition to identifying the obstacles that hinder the realization of this role from the teachers' point of view. In order to achieve this goal, the descriptive survey approach was used, and the questionnaire was used as a tool for data collection. The research community was represented in all teachers of Islamic studies in Taif Governorate, and a random sample of (295) male and female teachers was selected from …

Lessons Learned In Inclusive Game Design: Bridging The Gaps For Visually Diverse Players, Charvi Golechha, Sneha Patni, Shanu Priya Garg, Amrita Bhattacharjee Dr.

ServDes Conference Series

This paper presents a comprehensive study on the design, development, and evaluation of a multi-sensory board game, named Ezam, to bridge the participation gap between visually impaired and abled players. Using a user-centered, participatory design approach, the project integrates tactile, auditory, and spatial cues within a service-design framework to ensure a holistic, equitable gaming experience. The design process was informed by a market analysis of existing accessible board games and co-design sessions with over 50 visually impaired and sighted stakeholders across educational and community settings in India, and refined through iterative prototyping and rigorous user testing. Quantitative and qualitative evaluations …

Double-Cone Spiralling Model: Integrating Ancestral Elements And Future Possibilities In Service Design, Zijun Lin, Riccardo Torta, Beatrice Villari

ServDes Conference Series

As an interdisciplinary approach, service design (SD) has integrated multidisciplinary perspectives to extend its capability and reinforce its transformative role in addressing service (eco)system transformations. However, as both external and internal ecosystem dynamics introduce growing complexity and uncertainty, SD must continue to evolve its frameworks. This paper proposes a double-cone spiralling interpretive model for SD, outlining a potential spiralling trajectory of system transformation by bridging ancestral elements with future possibilities. The interpretive model draws on emerging SD frameworks that integrate transdisciplinary knowledge and case study analyses of illustrative examples. It highlights the importance of systemically considering ancestrality, long-term temporality, and …

Animation Film Industry Of India And Service Design: A Systematic Review Of Literature, Abhishek Kumar, Dr. Shikha Rai, Dr. Sonali Srivastav

ServDes Conference Series

The medium of animation transcends the physical limitations posed by other visual media, combining elements of fantasy with realism. By 2030, the animation business in India is expected to grow from ₹215.8 billion to ₹1.21 trillion. The major companies that dominate this segment in India are Disney and Pixar. The fact that the top 10 highest-grossing animation films in India are all produced by international companies, with ‘Kung Fu Panda 4(2024)’ at the top further demonstrating this foreign domination. Compared to its global counterparts, the Indian animation industry is yet to see the boom, despite the market accepting the medium. …

Empowering Rural Women Of Olasahi: Service Blueprint For A Community-Driven Sustainable Revenue Model, Gatikrushna Mohapatra, Seema Krishnakumar

ServDes Conference Series

This research paper explores the development of a sustainable business model for rural women in Olasahi, Jajpur, Odisha. Women in this region primarily engage in traditional snack-making but lack access to structured markets, have limited sources of revenue, and have limited financial awareness. The study integrates service design principles with entrepreneurship models to create a sustainable revenue framework enabling financial independence. A mixed-methods approach was employed, including surveys, focus group discussions, and case study analyses. The study highlights key barriers such as limited financial literacy, market inaccessibility, and a lack of structured business knowledge. It also identifies scalable solutions inspired …

Affordable Housing Using Bamboo: A Community-Driven Service Design Inquiry Using Creative What-If Exercises, Rajarshi Ray, Parthasarathi Mukhopadhyay

ServDes Conference Series

Affordable Housing (AH) remains a critical global issue, especially for economically weaker sections (EWS) of the developing countries like India. Non-affordability of typical building materials, make the EWS choose alternate materials like bamboo, which is traditionally-used in the tropics for being sustainable and affordable. However, challenges related to standardisation and societal perception hinder its mainstreaming. This warrants a holistic design approach like Service Design (SD), connecting different stakeholders involved with AH using bamboo, at the system level. While SD has wide application across different sectors, its role in building industry, remains relatively underexplored. Subsequently, four community-driven Indian initiatives are studied …

Invisible Hands, Indispensable Work: Human Centered Systemic Insights Into India’S Informal Service Of Domestic Work, Rahul Satish Mudukutore, Suprita Chaudhary, Debjani Roy, Veda Shetye, Mallika Kayastha

ServDes Conference Series

Domestic work in India constitutes a vast yet unregulated sector. This study employs a service centric approach to explore the systemic challenges faced by domestic workers. Through a mixed - methods approach including in - depth interviews, surveys, ethnographic studies, and service design analysis, we uncover key findings related to employment precarity, employer - worker power dynamics, and the informal nature of hiring practices. Our research highlights critical gaps in legal protections, lack of standardized employment contracts, and the socio - cultural barriers reinforcing domestic work as undervalued labour. Using stakeholder mapping, ecosystem analysis, and service blueprints, we identify intervention …