Digital Commons Network^™

Adenovirus Types In Us Children Hospitalized Or Seen In The Emergency Department With Acute Respiratory Illness, 2016-2019., Tess Stopczynski, Varvara Probst, Adam Gailani, Justin Z. Amarin, Olla Hamdan, Haya Hayek, Laura S. Stewart, Herdi K. Rahman, Rangaraj Selvarangan, Jennifer E. Schuster, Christopher J. Harrison, Mary E. Moffatt, Marian G. Michaels, John V. Williams, Julie A. Boom, Leila C. Sahni, Vasanthi Avadhanula, Mary Allen Staat, Elizabeth P. Schlaudecker, Christina Quigley, Geoffrey A. Weinberg, Peter G. Szilagyi, Janet A. Englund, Eileen J. Klein, Aaron T. Curns, Heidi L. Moline, Ariana P. Toepfer, James D. Chappell, Andrew J. Spieker, Natasha B. Halasa

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Human adenovirus (HAdV) is a common cause of pediatric acute respiratory illness (ARI), contributing to 5-13% of cases worldwide. Clinical manifestations vary by HAdV species and type; therefore, delineating type-specific disease presentations and understanding severity of specific HAdV types' disease may help develop targeted interventions.

METHODS: We conducted a multicenter, prospective study within the New Vaccine Surveillance Network to characterize HAdV types. Children < 18 years old with ARI were enrolled in the emergency department or inpatient setting at 7 US children's hospitals from 1 December 2016 to 30 November 2019. Respiratory specimens were collected and tested for HAdV and other viruses. Subsequently, typing was conducted on HAdV specimens using single-plex real-time PCR assays targeting sequences in the hexon gene. Comparisons between HAdV types were performed to determine differences in characteristics and outcomes. Generalized linear mixed effects models were used to evaluate severity.

RESULTS: Among the 1843 HAdV-positive cases, 1402 specimens (76%) were typed. The most common types detected were HAdV-C1 (n = 439), HAdV-C2 (n = 393), and HAdV-B3 (n = 221). Children with HAdV-B7 (n = 78) …

The Effect Of Shared Decisions On Intertemporal Choice, Rosemarie M. Davidson

Masters Theses

Substance use disorders are a significant public health concern, and improving treatment outcomes requires a better understanding of the behavioral processes that influence drug consumption. Delay discounting, or the tendency to overvalue immediate reinforcers, is reliably more severe among individuals with substance use disorders. Recent work suggests that shared decision-making may increase tolerance for delayed rewards; however, prior studies used procedures that confounded delay to token delivery with delay to token exchange, limiting conclusions. The present study evaluates delay discounting across individual and social decision-making contexts using a traditional delay discounting paradigm.

Ten undergraduate participants completed sessions involving choices between …

Clinical Long-Read Sequencing Test For Genetic Disease Diagnosis., Isabelle Thiffault, Emily G. Farrow, Cassandra Barrett, Meadow Scott, Amy Ross, John C. Means, Warren A. Cheung, Adam F. Johnson, Boryana Koseva, Rebecca Mclennan, Elin Grundberg, Chengpeng Bi, Carl F. Schreck, Byunggil Yoo, Jeffrey J. Johnston, Florencia Del Viso, Vitoria Paolillo, John Herriges, Lei Zhang, Margaret Gibson, Ana S A Cohen, Joseph Alaimo, Carol J. Saunders, Tomi Pastinen

Manuscripts, Articles, Book Chapters and Other Papers

This diagnostic study examines the diagnostic yield and turnaround time of long-read sequencing compared to standard-of-care approaches.

Overview Of Huntington's Disease And Emerging Treatment Strategies: A Narrative Review, Alexis J. Vega, Gabriel V. Hernandez, Pearse A. O'Malley, Connor J. Robin, Amanda N. Parra, Giustino Varrassi, Sahar Shekoohi, Alan D. Kaye

School of Medicine Faculty Publications

Huntington's disease (HD) is an autosomal dominant, progressive neurodegenerative disorder caused by a cytosine-adenine-guanine trinucleotide repeat expansion in the huntingtin (HTT) gene. The symptoms of HD include severe motor dysfunction, cognitive issues, and emotional dysregulation. These combined issues are not only debilitating but also lead to depression/anxiety, increased suicide rates, and caregiver burnout. Our narrative review summarizes several recent studies examining the efficacy and differences among emerging treatment strategies for HD. A systematic search of peer-reviewed literature was conducted, focusing on recent studies that describe molecular genetic manipulation of the HTT gene/huntingtin protein. The results of our narrative review reveal …

Evaluation And Identification Of Risk Factors For Stress Among Maquiladora Workers Based On The Mexican Official Standard 035 Survey Tool, Andrea Baca Melendez

Open Access Theses & Dissertations

Background and significance: Occupational psychosocial risk factors are workplace conditions that can trigger physiological, emotional, cognitive, and behavioral changes. They are strongly associated with mental health issues such as anxiety and depression, as well as non-mental health conditions like myocardial infarction, stroke, and occupational injuries. Analyzing these risks from a sociodemographic perspective provides valuable insights for improving work environments and workers’ well-being. Purpose: This study aimed to identify and determine the levels of occupational psychosocial risk factors among workers in a manufacturing company in Cd. Juárez, Chihuahua, and to examine their relationship with sociodemographic variables to inform future interventions in …

Does Social Media Undermine Trust? Institutional Trust In Civil Society And Governance Institutions, Christianna Sirindah Parr

Research Collection School of Social Sciences

What is the relationship between social media use and trust in civil society and governance institutions? In many parts of Asia, trust in government remains high despite limited political accountability and civil liberties. This study examines whether online political expression reshapes institutional trust in governance institutions and civil society organizations. The analysis considers the dual role of social media as a site for civic engagement and a channel for disaffection with formal authority. Using data from the Asian Barometer, the findings show that political expression on social media is associated with lower trust in governance institutions and higher trust in …

Tsunami Simulation And Boulder Transport Across Contrasting Coastal Geomorphologies In Sanriku, Japan, Storm Roberts, Daisuke Sugawara, Hidetoshi Masuda, Sarah Boulton

School of Geography, Earth and Environmental Sciences

Tsunami boulders serve as crucial indicators for reconstructing past tsunami events, yet their full transport process remains poorly understood. This study investigates tsunami boulder transport at two geomorphically distinct field sites in Japan affected by the 2011 tsunami, integrating field data with a validated tsunami simulation to track wave parameters at every transport stage. The simulation was validated against eyewitness accounts, local reports, and offshore GPS buoy data. Near the shoreline at the Settai site simulated flow velocities reached a maximum of 7.55 m/s, compared to 6.51 m/s at Hoshiyama beach. Inland at Settai, a maximum 15.56 m/s flow velocity …

The Persistence Of Homophobia In Men’S Friendship Norms, Sherrie Y. Xue, Stephanie C. Lin, Christilene Du Plessis

Research Collection Lee Kong Chian School Of Business

Across five studies and one supplementary study (five preregistered; N = 3,215 adults), we found that men, more than women, avoided shared experiences (e.g., going to the movies, sharing food) with individuals of the same gender. Furthermore, persistent societal expectations that men should be unambiguously heterosexual underpinned this pattern: Men felt more apprehensive about signaling same-gender romance in platonic relationships than women did. In turn, romantic prototypicality drove the pattern of men (more than women) avoiding shared activities, above and beyond differences in how hedonic, enjoyable, and feminine the activities were; our findings further suggested that men’s reluctance to share …

Aku Research 2025, Office Of Research And Graduate Studies

Office of Research and Graduate Studies

• With dementia surging, BMI seeks tools for prevention
• The past, present and future of teaching in Pakistan
• Transforming educations with evidence
• Research influences national teacher development programme
• Redefining the migrant experience
• Study finds women are underrepresented in East Africa’s media
• Study identifies targets for treating drug-resistant tuberculosis
• Addressing extreme heat’s impacts on the vulnerable
• Colorectal cancer detection gets an AI boost
• Addressing the quiet crisis of women’s mental health
• The pandemic was especially hard for female health workers
• Advancing reproductive health in Pakistan
• A push for advanced practice nursing and midwifery
• Major study yields essential data on maternal health
• Saving …

A Learning‑Augmented Dynamic Programming Approach For Orienteering Problem With Time Windows, Guansheng Peng, Lining Xing, Fuyan Song Ma, Aldy Gunawan, Aldy Gunawan

Research Collection School Of Computing and Information Systems

Recent years have witnessed a surge of interest in solving combinatorial optimization problems (COPs) using machine learning techniques. Motivated by this trend, we propose a learning-augmented exact approach for tackling an NP-hard COP, the Orienteering Problem with Time Windows, which aims to maximize the total score collected by visiting a subset of vertices in a graph within their time windows. Traditional exact algorithms rely heavily on domain expertise and meticulous design, making it hard to achieve further improvements. By leveraging deep learning models to learn effective relaxations of problem restrictions from data, our approach enables significant performance gains in an …

Semi‑Supervised Graph Anomaly Detection Via Robust Homophily Learning, Guoguo Ai, Hezhe Qiao, Hui Yan, Guansong Pang

Research Collection School Of Computing and Information Systems

Current semi-supervised graph anomaly detection (GAD) methods utilizes a small set of labeled normal nodes to identify abnormal nodes from a large set of unlabeled nodes in a graph. These methods posit that 1) normal nodes share a similar level of homophily and 2) the labeled normal nodes can well represent the homophily patterns in the entire normal class. However, this assumption often does not hold well since normal nodes in a graph can exhibit diverse homophily in real-world GAD datasets. In this paper, we propose RHO, namely Robust Homophily Learning, to adaptively learn such homophily patterns. RHO consists of …

Endoscopic Retrograde Cholangiopancreatography And Primary Sclerosing Cholangitis: A Retrospective Study Of A High-Volume Program, Kristel Leung, Michael Youssef, Yasi Xiao, Catherine Streutker, Aliya Gulamhusein, Bettina Hansen, Natalia Calo, Gary May, Jeffrey Mosko, Gideon Hirschfield

Division of Gastroenterology and Hepatology Faculty Papers

BACKGROUND: Endoscopic retrograde cholangiopancreatography (ERCP) is valuable in management of primary sclerosing cholangitis (PSC). Herein, we characterize individuals with PSC who underwent ERCP on-demand at a high-volume quaternary centre, with evaluation of pathology results and short-term postprocedural outcomes.

METHODS: This retrospective cohort study evaluated patients with PSC who underwent ERCP at St Michael's Hospital between April 2011 and July 2021. Chart review was conducted to collect clinical, procedural, and pathology data, and reported post-ERCP complications within 90 days. Logistic regression analyses were conducted to evaluate factors associated with post-ERCP complications and placement of a biliary stent.

RESULTS: One hundred and …

Relationships Between Social Determinants Of Health And Pain Outcome Changes After Exercise In Adults With Knee Osteoarthritis, Klarissa Siebert

Open Access Theses & Dissertations

Background: Knee osteoarthritis (KOA) is a common musculoskeletal disease with pain as the primary symptom. KOA pain is a major contributor to disability and reduced quality of life and has been associated with social determinants of health (SDOH) variables. As for treatments of KOA pain, exercise such as stationary cycling is a first-line and recommended treatment. However, limited research has examined how SDOH influence pain outcomes following such interventions. Objective: This study investigated whether income level, education level, employment status, acculturative stress, and perceived ethnic discrimination are associated with changes in pain following a standardized cycling ergometer exercise in adults …

Fusarium Equiseti Pathogen Of Potato In Kenya And Its Potential In Vitro Biocontrol Using Fungal Endophytes, Marie Cecile Muhorakeye, Fathiya M. Khamis, Everlyne Samita Namikoye, Komivi S. Akutse

All Peer-Reviewed Publications

Accurate pathogen diagnosis is fundamental for effective crop disease management. In Kenya, a pathogen causing significant damage in potato farms was initially misidentified as Phytophthora infestans. This study aimed to correctly identify this pathogen and explore initial control measures using a polyphasic approach. The methodology integrated morphological observation, pathogenicity testing, and molecular analysis using ITS and EF1-α gene sequencing. The results confirmed the pathogen’s identity as Fusarium equiseti, with morphological features consistent with this species and molecular sequencing showing 99.6% identity to reference strains. This is the first official report of Fusarium equiseti as a potato pathogen in Kenya. Furthermore, …

Federal Courts, Class Actions, And The Jurisdictional Void, Courtney T. Welch

Fordham Law Review

To invoke the jurisdiction of a federal court, a plaintiff must satisfy the requirements of Article III. Among other things, Article III requires a plaintiff to have and maintain personal stake throughout the lifespan of the litigation. Though a simple premise, this constitutional requirement has a complicated history. This is especially true as applied to class action lawsuits, where plaintiffs bring claims both on behalf of themselves and other harmed individuals.

The U.S. Supreme Court has applied flexible rules to some—but not all—of Article III’s requirements in class actions. The breadth of this flexibility, though, is uncertain. Accordingly, so too …

Benefits Of Animal Assisted Therapy In Pediatric Inpatient Units: A Literature Review, Logan M. Shiflett

The Eleanor Mann School of Nursing Undergraduate Honors Theses

The purpose of this systematic review of literature was to establish if animal assisted therapy (AAT) is helpful in the reduction of stress for patients on pediatric inpatient floors. The PICOT question that led this review was: In pediatric patients, how does animal assisted therapy affect patient outcomes related to increased hospitalizations? The EBSCOhost database, as well as the Web of Science and CINAHL Complete information sources, were used to find relevant studies for this review that assessed the benefits and contraindications for AAT. Key terms such as “animal assisted therapy,” “pediatrics,” and “inpatient” were used to narrow down the …

Potential Predictors Of Nonconductive Wood Column Volumes In Five Maple Species, Tanner Ryan Frost

Master's Theses and Capstones

Maple tapping guidelines rely on the understanding of nonconductive wood column (NWC) formation, but this process has only been studied in sugar maple and may be ineffective at advising producers in their tapping activities due to the variation in wounding between sites and the lack of research into alternative species more recently being brought to market. The goal of this study was to investigate sap sugar concentrations and sap yields as predictors of nonconductive wood column (NWC) volumes in five Acer species: sugar maple (Acer saccharum), red maple (Acer rubrum), silver maple (Acer saccharinum), Norway maple (Acer platanoides), and boxelder …

Modular And Combined Particle Swarm Optimization Algorithms For Extraterrestrial Resource Prospecting, Gregory Hatfield

Master's Theses and Capstones

The success of future crewed and autonomous space missions hinges on effectively utilizing in-situ resources available in the extraterrestrial environment to sustain missions and habitation. Prior to extraction of resources, such missions will require robust and efficient methods for extraterrestrial resource prospecting. However, traditional global optimization techniques struggle with the complex and non-convex search spaces inherent to mapping and identifying resource deposits on extraterrestrial surfaces.

This research addresses the resource prospecting problem by developing and evaluating novel variants of the Particle Swarm Optimization (PSO). Here, four novel algorithms, their variants, and four combined algorithms are rigorously tested and confirmed. The …

An Inter-Model Comparison Of Snow Water Equivalent In Watershed 3, Hubbard Brook Experimental Forest, For Winter 2023-2024, Ryan Reed

Master's Theses and Capstones

Estimates of snow water equivalent (SWE) are crucial for water availability and flood risk assessment due to the contribution of snow melt to increased surface runoff. However, many regions do not have observations of SWE, thus necessitating a robust method to estimate SWE for streamflow forecasting. Numerical snowpack models provide a potential way to estimate SWE in areas without observations. However, there are a multitude of snowpack models available, and they range greatly in their complexity. Even so, there have been few snowpack model intercomparisons to assess the trade-offs in model performance and complexity, and those that do exist did …

A Comparison Of Cultural Aspects Of Breastfeeding In The United States Vs Italy, Madison P. Wallace

The Eleanor Mann School of Nursing Undergraduate Honors Theses

Healthcare systems internationally differ from policies, funding and resources available, and it is evident when comparing the United States and Italy. Participation in the Nursing Across the Lifespan study abroad program at the University of Arkansas Rome Center and Tiny Tusk Breastfeeding and Infant Support internship inspired a comparative exploration of breastfeeding practices in the United States versus. Italy. The United States has a mixed public- private insurance system, workplace policies and government assistance, while Italy has a universal healthcare system with a mandated maternal work paid leave to support breastfeeding mothers. Italy's program supports education and physical care needed …

Enabling Injustice: Slapps, Democratic Values, And The Price Of Truth, Costantino Grasso

Buffalo Law Review

Conventional analysis of Strategic Lawsuits Against Public Participation (SLAPPs) often focuses on the promise of recent procedural reforms, including recent U.S. state-level reforms, the 2024 E.U. Anti-SLAPP Directive, the U.K. government’s 2025 SLAPP Bill, and related measures in the Economic Crime and Corporate Transparency Act. This Article argues that these legislative responses, introduced amid growing international concern, still leave structural vulnerabilities, have limited focus, and do not address the deep-seated inadequacies of substantive law that allow powerful actors to chill public-interest speech through abusive lawfare.

Adopting an interdisciplinary “new legal realist” approach, this Article decodes the anatomy of this modern …

National Security And Farmland Ownership: Livin’ Afida Loca, Jennifer Zwagerman

Buffalo Law Review

The brutal history of conflict over land demonstrates its importance for national security. Farmland in particular is in short supply and has appropriately been designated as “critical infrastructure.” However, the Committee on Foreign Investment in the United States (CFIUS) reviews foreign investment in farmland only if the farmland’s location is close to military or other sensitive sites. The United States Department of Agriculture (USDA) gathers information on specific types of foreign farmland investment yet is wholly removed from any type of national security review. While it might seem like a ban on foreign investment in farmland is an easy solution …

Suspending The Truancy Paradigm, Barbara Fedders, Lucy Carlson, Max Parker

Buffalo Law Review

In the aftermath of the COVID-19 pandemic, school absences have skyrocketed. While racially minoritized, disabled, and low-income students have historically been, and remain, most likely to experience absence, white and affluent students’ rates of attendance have also declined. To respond to this new universality of student absenteeism, some policymakers have begun to seek alternatives to what we term “the truancy paradigm.”

We define the truancy paradigm as the range of coercive and often punitive interventions deployed by states and school districts to enforce compulsory attendance statutes. This paradigm, we argue, wrongly assumes (a) that strict enforcement of compulsory attendance laws …

Conceptual Gerrymandering In Sffa And Some Thoughts On How It Enables The Case’S Weaponization, David Simson

Buffalo Law Review

This Article makes two main contributions at the intersection of Constitutional Law and critical analyses of race and racial (in)equality. First, and more narrowly, the Article provides an in-depth analysis and critique of the Supreme Court’s most recent affirmative action decision in Students for Fair Admission v. Harvard (SFFA), specifically with respect to a crucial aspect of the case that has not been addressed in depth in other scholarship on the decision: how key opinions conceptualize “race” in their reasoning. The Article shows how the SFFA majority opinion and a concurring opinion by Justice Gorsuch incorporate multiple, and inconsistent, understandings …

Presumed Guilt: Epistemic Closure In Pregnancy Prosecutions, M. Eve Hanan

Buffalo Law Review

Criminal law and reproductive justice scholars are calling attention to the increase in prosecutions for pregnancy outcomes in the United States. Trace amounts of controlled substances in newborns are prosecuted as child abuse. Miscarriages are prosecuted as illegal abortions or homicides. This area of criminal law existed side-by-side with Roe v. Wade for late-term pregnancy outcomes. The Dobbs decision has further emboldened these prosecutions by removing the protections of the Due Process Clause from the pre-viability phase of the pregnancy.

Using a case study of a woman who was pressured to plead guilty to manslaughter and sentenced to eight years …

Front Matter, Buffalo Law Review

Buffalo Law Review

No abstract provided.

Effects Of Maternal Overnutrition And Metabolic Challenge In Adult Life On The Histological Integrity Of The Liver And Intestinal Epithelium In Rabbits, Lucía Carolina Cano, Erika Navarrete, Pedro Medina, Juan Pablo Ochoa-Romo, Georgina Díaz, Rodrigo Montúfar-Chaveznava, Rosa María Vigueras-Villaseñor, Ivette Caldelas

Artículos científicos

Introduction: Maternal overnutrition during critical stages of embryonic development has been implicated as a major determinant of developmental and metabolic disturbances in offspring. Current data concerning how perinatal exposure to high-fat and high-carbohydrate diets, followed by re-exposure in adulthood (metabolic challenge), affects the metabolic regulation and structural integrity of the liver and small intestine, key organs of the gut–liver axis (GLA), are limited. Methods: Female rabbits were fed either a standard diet (SD) or a high-fat and high-carbohydrate diet (HFCD) before mating and during gestation. The offspring on postnatal day 440 were challenged with an HFCD or SD for 30 …

Driving Complex Thinking And Technological Entrepreneurship With Artificial Intelligence: A Mixed Methods Study, Inés Alvarez-Icaza, J. Miranda, A Martínez-Arboleda, P Suarez-Brito, María Soledad Ramírez-Montoya

Artículos científicos

AI technologies offer unique capabilities that enhance collaboration and creativity among students by providing novel insights, generating diverse perspectives, and triggering the development of innovative thinking as a subcompetency of the mega-competency of complex thinking. Regarding entrepreneurial skills development, applying AI-powered tools, such as natural language processing on digital educational platforms, allows students to engage in dynamic ideation processes for entrepreneurial projects with social, technological, and scientific approaches. This article explores the application of artificial intelligence (AI) as a valuable resource for fostering creative idea generation within co-creation strategies for university students. In a mixed-method analysis, we obtained valuable information …

Modelling The Balance Axiom In Flow Theory: A Physiological And Computational Approach In Steam Education, David Antonio Rosas, Natalia Padilla-Zea, Daniel Burgos

Artículos científicos

This paper addresses the axiom of balance in Flow Theory from a physiological-and-groupbased approach by a quasi-experimental study using mixed methods across two action– research cycles, each divided into pre-test, intervention, and post-test phases. The study involved 56 students in two control and two experimental groups attending robotics and design STEAM courses in natural settings, wearing Polar H10 bands. Each group participated in nine one-hour sessions, with the same instructor. While flow in control groups was measured with intuition-based teacher actions, in experimental groups the teacher received support from a synchronous physiological flow advisory system. Data from these groups were …

Leveling The Playing Field? Exploring The Moral Ambiguity Of The Private Attorney General Model, Nathan Heastie

Washington and Lee Law Review Online

Johnson & Johnson’s market cap is twice the GDP of Oklahoma. So, when Oklahoma hauled Johnson & Johnson and other behemoth pharmaceutical companies into state court for their participation in the opioid epidemic, Big Pharma’s resources created a David v. Goliath situation. Against all odds, Oklahoma stood toe-to-toe with Big Pharma and brought home more than $650 million in settlement funds.

Oklahoma’s success would be otherwise impossible without the assistance of three private law firms serving the role of “private attorneys general.” The State signed contingency fee arrangements with the firms, transferring the financial burden of litigation from the State …