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Quality Improvement Project Nursing Student Retention Strategies: A Focus On Peer Mentoring, Anh Vittoria Dec 2025

Quality Improvement Project Nursing Student Retention Strategies: A Focus On Peer Mentoring, Anh Vittoria

Doctor of Nursing Practice Projects

The nursing shortage remains a concern in healthcare. Increasing the number of students who complete nursing programs and enter the profession can help with the demand for nurses in the workforce. Nursing programs face challenges with student retention, which limits the number of nurses entering the profession. The quality improvement project aimed to examine the effects of a peer mentorship program on first-year associate degree nursing students’ perception of support and course completion rates. The purpose is to impact student retention and sense of support in an Associate Degree Nursing Program (ADN) through peer mentorship. The project was guided by …


Quality Improvement Project Enhancing Documentation Practices In Community Mental Health Clinics, Carol Parker Dec 2025

Quality Improvement Project Enhancing Documentation Practices In Community Mental Health Clinics, Carol Parker

Doctor of Nursing Practice Projects

Accurate and timely documentation are essential for safe, high-quality care in community mental health settings. This quality improvement (QI) project addressed inconsistent documentation practices among licensed, unlicensed, and Qualified Mental Health Specialist (QMHS) staff at an outpatient clinic. The purpose of the QI project was to implement and assess a structured in-service training program using the Accountable Health Communities–Health-Related Social Needs (AHC-HRSN) screening and documentation tool to improve staff knowledge, enhance documentation accuracy, and facilitate care coordination. Guided by the Iowa Model of Evidence-Based Practice and Lewin’s Change Management Model, a pre- and post-intervention design was used. Fifteen staff members …


Enhancing Mental Health Providers' Approach To Medication Adherence In Schizophrenia Patients Using Motivational Interviewing Techniques., Jacinta Madu Dec 2025

Enhancing Mental Health Providers' Approach To Medication Adherence In Schizophrenia Patients Using Motivational Interviewing Techniques., Jacinta Madu

Doctor of Nursing Practice Projects

Medication non-adherence among individuals with schizophrenia remains a persistent challenge that undermines symptom management and increases relapse and hospitalization rates. This quality improvement (QI) project aimed to evaluate the effect of Motivational Interviewing (MI) training on provider knowledge and confidence in promoting medication adherence within an outpatient mental health clinic. Guided by Lewin’s Change Theory and the Plan-Do-Study-Act (PDSA) framework, a quasi-experimental pre–post design was used. Six providers, including psychiatric nurse practitioners, therapists, a psychiatrist, and a registered nurse, participated in a structured MI training session incorporating didactic instruction and role-play exercises. Data were collected using pre- and post-intervention surveys …


Quality Improvement Project: Impact Of A Brief Mindfulness-Based Stress Reduction Program For Healthcare Providers Who Evaluate Veterans, Peng Anderson Dec 2025

Quality Improvement Project: Impact Of A Brief Mindfulness-Based Stress Reduction Program For Healthcare Providers Who Evaluate Veterans, Peng Anderson

Doctor of Nursing Practice Projects

Long-term stress can lead to healthcare provider burnout. Mindfulness-based interventions, even when shortened, may provide a promising and innovative method to reduce stress and prevent burnout. Research on mindfulness programs has demonstrated significant benefits for both providers and patients. This quality improvement project aims to evaluate the effect of a brief mindfulness-based stress reduction program (MBSR) for providers who evaluate veterans on the variable of mindfulness awareness compared to current site practice. Lewin’s change management model and Peplau’s Interpersonal Relations Theory were used. Plan-Do-Study-Act was the implementation framework applied. The design was pretest-posttest using the Mindful Attention Awareness Scale (MAAS). …


Current Knowledge And Perspectives Of Relative Energy Deficiency In Sport In An Athletic Environment, Meredith Rebecca Morgan Dec 2025

Current Knowledge And Perspectives Of Relative Energy Deficiency In Sport In An Athletic Environment, Meredith Rebecca Morgan

Electronic Theses and Dissertations

Sport performance personnel are in a unique position to directly impact athletes. While the primary individuals who manage athlete health are physicians, sport dietitians, and certified athletic trainers, sport coaches and strength and conditioning coaches also play an impactful role in an athlete’s performance and well-being. Using an original survey, this study investigated REDs knowledge by certified athletic trainers, strength and conditioning coaches and sport coaches. The survey was employed to assess sport performance professionals’ general knowledge of Relative Energy Deficiency in Sport (REDs) and low energy availability (LEA) and opinions on the role of health professionals in REDs identification, …


Processing Self, Ethan B. Mckellar Dec 2025

Processing Self, Ethan B. Mckellar

All Theses

Processing Self is a body of sculptural and utilitarian ceramic work that explores the intersection of the materiality of clay with the expression of grief and vulnerability. In this work I utilize the process of building unstable ceramic vessels and the communal action of wood firing to translate the experiences of grief and care into physical forms. As I build, I manipulate the clay to its limits, allowing it to falter under its own weight, and display the breakage and damage. By committing to support each vessel through its creation, I make a promise to persevere, echoing the commitment I …


Parental Experiences With Financial Toxicity In The Pediatric Intensive Care Unit: A Phenomenological Research, Sohrab Alexander Sardual Dec 2025

Parental Experiences With Financial Toxicity In The Pediatric Intensive Care Unit: A Phenomenological Research, Sohrab Alexander Sardual

Dissertations and Theses (Open Access)

Background: Parents of children admitted to the pediatric intensive care unit (PICU) encounter multiple stressors; however, there is a need to further understand their experiences with financial toxicity. Understanding parents’ experiences and perspectives on how they can be assisted is a critical first step to formulating interventions to help parents deal with financial toxicity.

Aims: The aims of this study are (a) to describe the experiences with financial toxicity of parents with critically ill children admitted to the PICU and (b) to explore parents’ perspectives on how they can be assisted in dealing with financial toxicity.

Methods: A phenomenological qualitative …


University Of Nebraska At Omaha Commencement: December 2025, University Of Nebraska At Omaha Dec 2025

University Of Nebraska At Omaha Commencement: December 2025, University Of Nebraska At Omaha

Commencement Programs

No abstract provided.


Political Discoveries In A Žižek Substack Project Critical Digital Studies, Edward Sankowski, Betty J. Harris Dec 2025

Political Discoveries In A Žižek Substack Project Critical Digital Studies, Edward Sankowski, Betty J. Harris

International Dialogue

This review essay analyzes Slavoj Žižek’s recent turn to Substack as a publishing platform, examining both his motivations and the philosophical and political implications of this medium for contemporary critical theory. Sankowski and Harris argue that Žižek’s Substack writings continue long-standing themes in his work—anti-capitalism, ecological crisis, updated Communism, and the cultural dimensions of ideology—while also revealing notable shifts, including heightened pessimism about historical progress and new reflections on environmental catastrophe. The authors assess the advantages and pitfalls of Substack for intellectual discourse, including its circumvention of traditional editorial “censorship,” its contribution to information glut, and its role in fostering …


Of The Freedom Famine In Palestine, Ibtisam Barakat Dec 2025

Of The Freedom Famine In Palestine, Ibtisam Barakat

International Dialogue

In this searing essay, poet and author Ibtisam Barakat bears witness to what she names the “Freedom Famine” in Gaza—a deliberate, decades-long deprivation of basic human rights culminating in the catastrophic conditions of 2025. Writing from the United States while in conversation with Gazan author Omar Hammash, Barakat juxtaposes their drastically unequal realities: her safety and his daily encounters with death, displacement, and starvation. Through Hammash’s testimony—delivered amid constant bombardment and interrupted by news of a friend’s killing—Barakat documents the collapse of Gaza’s infrastructure, the mass targeting of aid workers, the lethal failures of international relief, and the killing of …


Dear Belvedere, Rabbya Naseer Dec 2025

Dear Belvedere, Rabbya Naseer

International Dialogue

In this powerful open letter—originally delivered as a video message—artist Rabbya Naseer explains her decision to cancel her 2025 solo exhibition at Belvedere 21 after the museum refused to allow her proposed works addressing Palestine, colonialism, and contemporary violence. Framed as both personal testimony and institutional critique, the letter meditates on the ethics of waiting, perseverance (sabr), and the responsibility of artists amid geopolitical crisis. Naseer recounts months of stalled communication and escalating curatorial restrictions that ultimately rendered any engagement with the Israel–Palestine conflict “not possible.” Rejecting the museum’s demands for neutrality, depoliticization, and the substitution of existing …


Effect Of Focussing On Anastatica Hierochuntica Flower On Labour Pain, Duration Of Labour And Perceived Fatigue During Labour: Randomized Controlled Study, Emine Koç, Şükran Başgöl, Sümeyye Bal, Sabire Kirtiloğlu Dec 2025

Effect Of Focussing On Anastatica Hierochuntica Flower On Labour Pain, Duration Of Labour And Perceived Fatigue During Labour: Randomized Controlled Study, Emine Koç, Şükran Başgöl, Sümeyye Bal, Sabire Kirtiloğlu

Journal of Asian Midwives (JAM)

Background: Maternal fatigue and pain during labour can adversely affect the health of the mother, fetus, and newborn. Anastatica hierochuntica is a plant traditionally used in some cultures during childbirth rituals. When placed in water, the dried flower gradually unfolds and symbolically represents the opening of the uterus and birth canal. This study aimed to investigate the effect of focusing on the Anastatica hierochuntica flower during labour on labour pain, duration, and perceived fatigue.
Methods: This randomized controlled trial was conducted in the delivery unit of a mother-friendly hospital with 119 participants 60 in control group and 59 in intervention …


Factors Associated With Preterm Premature Rupture Of Membranes: A Case-Control Study In A Tertiary Hospital In Kabul, Afghanistan, Atia Sharif Nadi, Freshta Sharif Tawakkuli, Zainab Sharif Ezadi, Sayed Murtaza Sadat Hofiani, Shoaib Murtaza Sadat Naeemi, Ahmad Komail Frogh Dec 2025

Factors Associated With Preterm Premature Rupture Of Membranes: A Case-Control Study In A Tertiary Hospital In Kabul, Afghanistan, Atia Sharif Nadi, Freshta Sharif Tawakkuli, Zainab Sharif Ezadi, Sayed Murtaza Sadat Hofiani, Shoaib Murtaza Sadat Naeemi, Ahmad Komail Frogh

Journal of Asian Midwives (JAM)

Background: It is essential to identify preterm premature rupture of membranes (PPROM) and its associated risk factors to reduce its impact. This study aims to find the demographic, reproductive, and obstetric factors associated with PPROM among women in Kabul, Afghanistan.
Methods: This case-control study was conducted over six months in 2023 at a tertiary hospital in Kabul, Afghanistan. We included 40 cases of PPROM and 80 controls without PPROM in this study. We used structured questionnaires to collect demographic, reproductive, and obstetric characteristics of the participants. To find the factors associated with PPROM, Logistic regression was performed using IBM SPSS …


A Scoping Review Of Maternal Active Smoking During Pregnancy And Low-Birth Weight, Naomi Sondang, Nindi Oktavia, Qorinah Estiningtyas Sakilah Adnani, Lani Gumilang, Hadi Susiarno, Victor Abiola Adepoju Dec 2025

A Scoping Review Of Maternal Active Smoking During Pregnancy And Low-Birth Weight, Naomi Sondang, Nindi Oktavia, Qorinah Estiningtyas Sakilah Adnani, Lani Gumilang, Hadi Susiarno, Victor Abiola Adepoju

Journal of Asian Midwives (JAM)

Background: Low-birth weight (LBW; < 2.5 kg) infants are at increased risk of early mortality, impaired growth, neuro-developmental delay and chronic disease later in life. Maternal behavior, especially cigarette smoking, remains one of the most modifiable determinants of birth weight. We therefore synthesized recent evidence on the association between active maternal smoking during pregnancy and LBW.
Methods: Following PRISMA guidance, we systematically searched PubMed, Scopus and ScienceDirect for the period January 2020 to 31 January 2025 for English-language observational studies that quantified the relationship between active prenatal smoking and LBW. Risk of bias was appraised, and findings were summarized narratively.
Results: In total 26,650 papers were found and eight eligible studies (four cohort, three cross-sectional, one case-control) from Asia, Europe and the Middle East were included. Across all designs and exposure metrics—self-report, exhaled carbon-monoxide, urinary cotinine, and cord-blood DNA-methylation, active smoking was consistently associated with …


Neurology Residency Training In Pakistan: Current Status And Future, Bashir Soomro Dec 2025

Neurology Residency Training In Pakistan: Current Status And Future, Bashir Soomro

Pakistan Journal of Neurological Sciences (PJNS)

No abstract provided.


Alarming Rate Of Hemorrhagic Stroke Showing An Urgent Need For Hypertension Control: A Retrospective Study From A Major Stroke Center In Sindh, Sana Ghous, Muhammad Hashim Kalwar, Muhammad Hassan Butt, Irfan Ali Vighio, Mehfooz Ali Shah, Javed Khurshed Shaikh, Mansoor Hassan Dec 2025

Alarming Rate Of Hemorrhagic Stroke Showing An Urgent Need For Hypertension Control: A Retrospective Study From A Major Stroke Center In Sindh, Sana Ghous, Muhammad Hashim Kalwar, Muhammad Hassan Butt, Irfan Ali Vighio, Mehfooz Ali Shah, Javed Khurshed Shaikh, Mansoor Hassan

Pakistan Journal of Neurological Sciences (PJNS)

Background and Objective:

Hemorrhagic stroke accounts for approximately 18–20% of the global stroke burden and is associated with high mortality and disability. It poses a significant challenge in low- and middle-income countries, where delayed presentation and inadequate risk factor control worsen outcomes. Hypertension remains the most important modifiable risk factor, particularly when poorly controlled. The objective of this study was to investigate the incidence of hemorrhagic stroke at a major stroke center and its association with uncontrolled hypertension.

Methods:

This retrospective study was conducted at Sindh institute of cardiovascular diseases (SICVD) Sukkur over three months, from May to July 2024. …


Dancing With Logic: The Impact Of Integrating Dance In Teaching Introductory Computer Science Concepts On Student Understanding And Engagement, April Monk Dec 2025

Dancing With Logic: The Impact Of Integrating Dance In Teaching Introductory Computer Science Concepts On Student Understanding And Engagement, April Monk

Master's Theses

The purpose of this study was to investigate the effectiveness of dance-integrated pedagogical methods in enhancing the learning experiences of students in an introductory computer science course. In particular, the research aimed to measure the impact of creative movement on student comprehension, engagement, and perceptions of computer science. To guide this investigation, the study explored three research questions: Does integrating dance into lessons impact students’ comprehension of fundamental computer science concepts? How does dance integration affect student perceptions of both dance and computer science? And what elements of dance contribute to differences in comprehension between dance-integrated and traditional lessons? A …


Effectiveness Of Education On Increasing Training Likelihood: An Analysis In Relation To Physique Inflation, Reid J. Venable Dec 2025

Effectiveness Of Education On Increasing Training Likelihood: An Analysis In Relation To Physique Inflation, Reid J. Venable

Honors College Theses

Resistance training is a widely recommended form of exercise for enhancing muscular strength, improving metabolic health, and promoting overall quality of life. In addition to these benefits, perhaps the most popular reason for participating in resistance training is to achieve muscle hypertrophy and attain a desired or aesthetic physique. However, various factors such as the use of performance-enhancing drugs and social media have led to “physique inflation,” a cultural phenomenon in which exposure to highly enhanced or unrealistic body types shifts perceptions of what is considered a “normal” or attainable physique. As a result, many individuals avoid or delay resistance …


Strategic Business Planning For An Optometry Practice: A Comprehensive Approach To Market Analysis, Operations, And Growth, Molly Elizabeth Weber Dec 2025

Strategic Business Planning For An Optometry Practice: A Comprehensive Approach To Market Analysis, Operations, And Growth, Molly Elizabeth Weber

Honors College Theses

This study is a comprehensive analysis of the field of optometry in order to develop a business plan which could be utilized to open a new optometry practice. Strengths, weaknesses, opportunities, and threats are all studied in order to gain a robust view and offer insights of how a business would fair in the field of optometry to allow entrepreneurs to make informed decisions in business endeavors involving practice operations, market terrain, and growth potential.


Indexing A Spanish Choir Book To Trace Its Provenance, Amelia Lutz Dec 2025

Indexing A Spanish Choir Book To Trace Its Provenance, Amelia Lutz

Honors College Theses

A choir book from the rare books collection at Saint Meinrad Archabbey has little established about it beyond its dimensions and its label “Spanish Gradual.” By first exploring the historical context of liturgical books created after the Council of Trent for use in Spain, implementing a paleographical analysis, and indexing the chants included in the choir book (cantorale), I have established evidence to suggest its dates and likely origin. Following Fr. Columba Kelly’s framework for analyzing chant, I have begun a comprehensive index of the chant melodies and feast days included in the Spanish Gradual for Cantus Database.


What Does Genius Look Like? Investigating Brilliance Bias In Ai-Generated Images, Juliana Shihadeh, Margareta Ackerman, David Loker Dec 2025

What Does Genius Look Like? Investigating Brilliance Bias In Ai-Generated Images, Juliana Shihadeh, Margareta Ackerman, David Loker

Computer Science and Engineering

Text-to-image models, like Midjourney, DALL-E, and Stable Diffusion, have been shown to reinforce harmful biases, often perpetuating outdated and discriminatory stereotypes. In this study, we delve into a particular bias largely overlooked in generative image research: Brilliance Bias. By age 6, many children begin to internalize the damaging notion that intellectual brilliance is a male trait—a belief that persists into adulthood. Our findings demonstrate that popular image AI models possess this bias, further entrenching the misguided notion that exceptional intelligence is inherently male. This study calls for addressing brilliance bias in AI to ensure a more realistic representation of intellectual …


Prevalence And Characterization Of Post-Acute Sequelae Of Sars-Cov-2 Infection (Pasc) In Rwanda, Fernand Rwamwejo, Vivianne Umuhire Niyonkuru, Gilbert Rukundo, Eric Remera, Edson Rwagasore, Les Sztandera, Ruranga Charles, Elizabeth Krebs Dec 2025

Prevalence And Characterization Of Post-Acute Sequelae Of Sars-Cov-2 Infection (Pasc) In Rwanda, Fernand Rwamwejo, Vivianne Umuhire Niyonkuru, Gilbert Rukundo, Eric Remera, Edson Rwagasore, Les Sztandera, Ruranga Charles, Elizabeth Krebs

School of Business Faculty Papers

Objectives

Reliable, population-level estimates of post-acute sequelae of SARS-CoV-2 infection (PASC) remain scarce for sub-Saharan Africa. We aimed to quantify PASC prevalence and identify associated factors among adult COVID-19 survivors in Rwanda.

Methods

A nationally representative cross-sectional telephone survey (August-October 2024) sampled 3143 adults from the national COVID-19 registry. PASC was defined as new or persisting symptoms ≥3 months after acute illness and lasting ≥2 months. The prevalence was calculated, and multivariable logistic regression identified factors independently associated with PASC.

Results

Overall, PASC prevalence was 34%. Leading symptoms were back pain, headache, dizziness, fatigue, and reduced sexual desire. Higher odds …


Degradation Of Cobalt Chrome Molybdenum Hip And Knee Implants In Vivo And In Vitro, Peter William Kurtz Dec 2025

Degradation Of Cobalt Chrome Molybdenum Hip And Knee Implants In Vivo And In Vitro, Peter William Kurtz

All Dissertations

Cobalt Chrome Molybdenum (CoCrMo) remains a popular material choice for femoral condyles in total knee arthroplasty and for acetabular liners in dual mobility total hip designs. CoCrMo has been phased out of conventional THA designs due to its correlation with adverse effects such as ALTR and ALVAL. It is less understood if the mechanisms (i.e. abrasive wear to the surface of the implant) that release metal ions into the surrounding tissue occur at similar rates as seen in conventional THA. Additionally, it is unknown what effect the secondary damage modes such as electrocautery damage and adhesive wear have on these …


Power Distribution Controller For Formula Sae Vehicles, Michael Yuen Dec 2025

Power Distribution Controller For Formula Sae Vehicles, Michael Yuen

Electrical Engineering

The Power Distribution Controller (PDC) is designed for low-voltage (12V) automotive applications, specifically Formula SAE vehicles. It aims to replace the current and outdated MOSFET-based system, which suffers from inefficiencies such as lossy current sense resistors and limited configurability. Instead, this new system uses a PROFET-based architecture controlled over the Controller Area Network (CAN) and an updated microcontroller, enabling intelligent power management and data logging.

Designed with FSAE regulations in mind, the PDC not only enhances the reliability of low-voltage systems but also provides a quickly adaptable solution to fuse boxes. It achieves this by providing firmware-adjustable overcurrent protection, incorporating …


Climate Change In The Courts: A 2025 Retrospective, Maria Antonia Tigre, Margaret Barry Dec 2025

Climate Change In The Courts: A 2025 Retrospective, Maria Antonia Tigre, Margaret Barry

Sabin Center for Climate Change Law

Drawing from cases collected in the Sabin Center’s Climate Litigation Database, this report offers insights into global climate litigation developments during 2025. This third installment in our year-end series provides a snapshot of how the field of climate litigation evolved over the course of the year. The report revisits significant rulings from around the world and connects them to eight illustrative themes: (1) climate change in international courts and tribunals; (2) environmental assessment and permitting; (3) non-compliance with climate commitments; (4) constitutional and human rights; (5) greenwashing and climate-washing; (6) corporate accountability cases; (7) standing; and (8) deregulatory suits.


Stayin’ Alive: Examining The Moderating Effect Of Suicide Resilience On The Relationship Between Sexual Minority Stress And Subjective Well-Being, Natalie A. Sachs Dec 2025

Stayin’ Alive: Examining The Moderating Effect Of Suicide Resilience On The Relationship Between Sexual Minority Stress And Subjective Well-Being, Natalie A. Sachs

Dissertations

Suicidality among sexual minorities is concerning and results from increased social stress, societal stigma, and experiences of discrimination. The effects of sexual minority stress (SMS) lead to negative outcomes for sexual minority college students. The purpose of the current study was to better understand the role of suicide resilience in moderating the adverse effects of SMS among sexual minority college students. The following research questions and hypotheses guided this study: Q1 Does SMS have any effect on subjective well-being among college-student sexual minority individuals (SMIs)? Q2 Does SMS have any effect on suicide resilience among college student SMIs? Q3 To …


Hypercalcemia Of Down Syndrome., Seth Lmb, Melissa Litao, Nasreen Talib, Jacob M. Redel Dec 2025

Hypercalcemia Of Down Syndrome., Seth Lmb, Melissa Litao, Nasreen Talib, Jacob M. Redel

Manuscripts, Articles, Book Chapters and Other Papers

We present a case of hypercalcemia in a 12-month-old female with Down syndrome. The patient presented with significant weight loss (810 g since her 6-month visit) and severe growth failure (weight 5.8 kg, -4.5 SDs). Laboratory evaluation revealed severe hypercalcemia with appropriately suppressed PTH and 1,25-hydroxyvitamin D levels. Renal ultrasound confirmed medullary nephrocalcinosis. After excluding common etiologies, the patient was diagnosed with hypercalcemia of Down syndrome, also termed Abnormal Calcium, Calcinosis, Creatinine in Down syndrome. Treatment with intravenous fluids, calcitonin, and transition to a low-calcium formula (Calcilo XD) normalized serum calcium levels. The patient maintained normal calcium levels on restricted …


Categorizing Weight Growth Of Infants Born Before 32 Weeks' Gestation Using The 2023 Postnatal Growth Charts For Preterm Infants., Fu-Sheng Chou, Hung-Wen Yeh, Crystal Hsueh, Jing Zhang, Maria Fe B. Villosis, Karine Barseghyan, Ashwini Lakshmanan, Reese H. Clark Dec 2025

Categorizing Weight Growth Of Infants Born Before 32 Weeks' Gestation Using The 2023 Postnatal Growth Charts For Preterm Infants., Fu-Sheng Chou, Hung-Wen Yeh, Crystal Hsueh, Jing Zhang, Maria Fe B. Villosis, Karine Barseghyan, Ashwini Lakshmanan, Reese H. Clark

Manuscripts, Articles, Book Chapters and Other Papers

OBJECTIVE: To categorize growth and correlate growth categories with morbidities in infants born before 32 weeks of gestation.

STUDY DESIGN: This retrospective study categorized weight growth by correlating mean growth velocity (GV) with growth trajectory z-score changes (ΔGTZ ), as measured using 2023 Postnatal Growth Charts for Preterm Infants. The associations between weight categories and morbidities were assessed.

RESULTS: Weight gain of infants without morbidities was categorized into three groups based on correlating ΔGTZ with mean GV: slower ( ΔGTZ < -0.1), in-parallel ( ΔGTZ -0.1 to 0.3), and faster ( ΔGTZ > 0.3). The proportions of infants with and without morbidities in these categories were evaluated across two distinct cohorts, revealing similar …


Social Well-Being Moderates Behavioral Therapy Response For Generalized Anxiety Disorder., Jacob D. Armstrong, Nicole R. Baughman, Ricardo A. Wilhelm, Dalia El-Shafie, Hannah Berg, Hung-Wen Yeh, Elisabeth Akeman, Christopher Martell, Kate B. Wolitzky-Taylor, Michelle G. Craske, Martin P. Paulus, Robin Aupperle Dec 2025

Social Well-Being Moderates Behavioral Therapy Response For Generalized Anxiety Disorder., Jacob D. Armstrong, Nicole R. Baughman, Ricardo A. Wilhelm, Dalia El-Shafie, Hannah Berg, Hung-Wen Yeh, Elisabeth Akeman, Christopher Martell, Kate B. Wolitzky-Taylor, Michelle G. Craske, Martin P. Paulus, Robin Aupperle

Manuscripts, Articles, Book Chapters and Other Papers

INTRODUCTION: Identifying moderators of treatment outcome for depression and anxiety offers promise for personalizing treatment or providing novel intervention targets. Indices of social well-being have emerged as candidate moderators due to their robust impact on mental health and quality of life. Here, we examine whether measures of social support, isolation, and loneliness moderate outcomes to behavioral activation (BA) and exposure-based therapy (EXP) for individuals with GAD.

METHODS: This secondary analysis of a randomized clinical trial included 69 participants (31 EXP, 38 BA). Participants completed the GAD-7, along with NIH PROMIS (Depression; Social Isolation; and Emotional, Instrumental, and Informational Support) and …


Clinical Pharmacogenetics Implementation Consortium Guideline For Nat2 Genotype And Hydralazine Therapy., Michael T. Eadon, David W. Hein, Michael A. Andersen, Arlene B. Chapman, Rhonda M. Cooper-Dehoff, Zeruesenay Desta, Julio D. Duarte, Amanda L. Elchynski, Andrea Gaedigk, Seth E. Karol, Nita A. Limdi, Christelle Lteif, Laura Sosinski, Pablo Zubiaur, Michelle Whirl-Carrillo, Teri E. Klein, Kelly E. Caudle, Roseann S. Donnelly, José A G Agúndez Dec 2025

Clinical Pharmacogenetics Implementation Consortium Guideline For Nat2 Genotype And Hydralazine Therapy., Michael T. Eadon, David W. Hein, Michael A. Andersen, Arlene B. Chapman, Rhonda M. Cooper-Dehoff, Zeruesenay Desta, Julio D. Duarte, Amanda L. Elchynski, Andrea Gaedigk, Seth E. Karol, Nita A. Limdi, Christelle Lteif, Laura Sosinski, Pablo Zubiaur, Michelle Whirl-Carrillo, Teri E. Klein, Kelly E. Caudle, Roseann S. Donnelly, José A G Agúndez

Manuscripts, Articles, Book Chapters and Other Papers

Hydralazine is a vasodilator typically used in the treatment of resistant hypertension and heart failure. N-acetyltransferase 2 (NAT2) catalyzes the metabolism of hydralazine into inactive metabolites. NAT2 poor metabolizers (historically referred to as "slow acetylators") are predicted to have increased plasma hydralazine concentrations compared with NAT2 rapid and intermediate metabolizers (historically referred to as "rapid acetylators" and "intermediate acetylators," respectively), which may lead to both increased clinical efficacy and adverse effects, including drug-induced systemic lupus erythematosus. This guideline summarizes the evidence from the literature relevant to NAT2/hydralazine and provides recommendations for hydralazine prescribing based on NAT2 genotype-predicted acetylator phenotype (updates …