Digital Commons Network^™

Her2-Low And Her2-Ultralow Metastatic Breast Cancer And Trastuzumab Deruxtecan: Common Clinical Questions And Answers, Nusayba A Bagegni, Karthik V Giridhar, Daphne Stewart

2020-Current year OA Pubs

Approximately 80% of invasive breast cancers are classified as human epidermal growth factor receptor 2 (HER2)-negative; however, many of these tumors have detectable levels of HER2 surface expression. Trastuzumab deruxtecan (T-DXd) is a HER2-directed antibody-drug conjugate with a membrane-permeable payload that is cytotoxic to both HER2-expressing tumor cells and neighboring cells via the bystander antitumor effect. T-DXd has shown significant antitumor activity in clinical trials for patients with HER2-positive (immunohistochemistry [IHC] 3+ or IHC 2+/in situ hybridization [ISH]+) breast cancer. In addition, the results of the DESTINY-Breast04 trial demonstrated the clinical benefit of T-DXd in patients with HER2-low (IHC 1+ …

Investigating The Polygenic Relationship Between Heavy Cannabis Use And Schizophrenia In The All Of Us Research Program, Isabelle Austin-Zimmerman, Hayley H A Thorpe, John J Meredith, Jibran Y Khokhar, Tian Ge, Marta Di Forti, Arpana Agrawal, Emma C Johnson, Sandra Sanchez-Roige

2020-Current year OA Pubs

BACKGROUND: Decades of research have identified a strong association between heavy cannabis use and schizophrenia (SCZ), with evidence of correlated genetic factors. However, many studies on the genetic relationship between cannabis use and psychosis have lacked data on both phenotypes within the same individuals, creating challenges due to unmeasured confounding. We aimed to address this by using multimodal data from the All of Us Research Program, which contains genetic data as well as information on SCZ diagnosis and cannabis use.

METHODS: We tested the association between cannabis use disorder (CUD) and SCZ polygenic scores (PGSs) with SCZ and heavy cannabis …

Invisible No More: National Solutions For Protecting Unaccompanied And Separated Migrant Children In Egypt, Enas Abdel Azim, Noran Khorsheed, Raghda Bahy Elessawy, Tharwat Abaza

Papers, Posters, and Presentations

Egypt has a strategic geographical position as a significant destination and transit country for unaccompanied and separated migrant children (UASC). With a substantial and rapidly increasing migrant population, exacerbated by recent regional influxes, the country’s public infrastructure and resources are experiencing considerable strain. While Egypt has demonstrated its commitment to child rights through the ratification of key international instruments like the Convention on the Rights of the Child (CRC) and the African Charter on the Rights and Welfare of the Child (ACRWC), UASC in the country nonetheless face complex protection challenges, including legal visibility concerns, risk for exploitation, and barriers …

Plan Your Way To Tenure And/Or Promotion, Wendy Doucette, Jill Cirasella

Journal of Graduate Librarianship

In this editorial, we share our best advice for preparing the dossier necessary for professional advancement. While our advice is unavoidably shaped by the specifics of our experiences and universities, we believe most of it is broadly applicable to academic librarians in general. We cluster our advice into three categories: framework and planning, building your portfolio, and ongoing recordkeeping. We hope this “from the ground up” presentation will help those new to academic librarianship, though it’s never too late for more experienced librarians to (re)consider their own approaches.

A Temple For The Creator To Abide: The Soul Sanctuary In Ellen G. White’S Writings, Abner F. Hernández

Ellen White Issues Symposium

No abstract provided.

The Holy Spirit As A Representative Of Christ In Ellen G. White’S Writings, Denis Kaiser

Ellen White Issues Symposium

No abstract provided.

Pedagogies Of Peace And Justice In Integrated Israeli-Palestinian Youth Programs, Tchelet L. Tutman, Aviv Cohen

Peace and Conflict Studies

This qualitative study investigates how pedagogical choices in Israeli-Palestinian peace education programs shape the enactment of educational aims related to citizenship, justice, and democratic engagement. Drawing on interviews, observations, and document analysis from four educational organizations working with Jewish and Palestinian citizens of Israel, the study explores how educators navigate core dilemmas including whether and how to address the conflict directly, contend with language asymmetries, respond to participant resistance, and facilitate dialogue during periods of political violence. The analysis develops four pedagogical models: Neither-Nor, Both-And, Encounter, and Conflict Without Meeting, which capture distinct strategies for balancing intergroup interaction with engagement …

Beyond Gun Control: How March For Our Lives Frames Gun Violence Prevention As Positive Peace, Ashley E. Nickels, Amanda D. Clark

Peace and Conflict Studies

March for Our Lives (MFOL) is a youth-led social movement that has redefined the framing of gun violence prevention, expanding it beyond policy-focused gun control efforts to a broader vision of positive peace. Rather than positioning gun violence solely as a matter of firearm regulation, MFOL constructs it as a structural justice issue, linking it to systemic inequities such as racial oppression, economic inequality, and political disenfranchisement. This study examines how MFOL’s movement framing reshapes understandings of gun violence prevention by emphasizing community transformation, intersectional justice, and collective safety. Drawing on framing theory, we analyze how MFOL presents gun violence …

Beyond Precedent: Sexual Violence As An Act Of Genocide In The International Criminal Tribunal For Rwanda, Ciara Kilroy

Peace and Conflict Studies

Wartime sexual violence (WSV) has been a characteristic of violent conflict throughout recorded history, yet has failed to illicit the same international attention and condemnation as other war crimes. WSV has also been a particularly pervasive method of destruction during genocide, in which women make up the majority of victims and are targeted for both their gender and group membership. However, sexual violence is not enumerated as a crime of genocide in the 1948 Genocide Convention. Despite its absence from the formal genocide convention, legal institutions have still attempted to hold perpetrators responsible for sexual violence during genocide. This paper …

Women As Strategic Partners In Peacebuilding And Social Cohesion In Rural- Based Mining Areas: The Case Of Wards 1 And 2 Insiza District, Matebeleland South In Zimbabwe, Dumisani Maqeda Ngwenya, Sikhathele Mathambo

Peace and Conflict Studies

This article discusses the efficacy of the “women as strategic partners in peacebuilding” program, under the broader overarching Building Resilience, Inclusiveness, Social Cohesion and Healing Project, which is a response to the gendered conflicts and violence caused by the presence of artisanal mining in two wards of Insiza District, Matebeleland South in Zimbabwe. The intervention was premised on strengthening women’s capacity to create safe platforms for inclusive dialogue, consensus-building and decision making to address conflicts and creating a conducive environment for collaboration and trust, to enhance social cohesion and build a more peaceful society. Peace committees (PCs) established by Emthonjeni …

Healing Through History, Nancy Baker Jones

Journal of Texas History

This is the written transcription of the author’s closing plenary address to the inaugural conference of the Alliance for Texas History, May 17, 2025. Its purpose is to put into both broad and personal historical contexts the events of 2023 and 2024 that led to the founding of the Alliance for Texas History. It concludes that, despite the difficulties of those events for her and for many other historians of Texas, history offers a potentially healing context for moving forward.

Military Operations, Jerry Gross

Bob Schieffer Vietnam War Collection

Navy news summary of events that occurred during Operation Jack Stay by Jerry Gross in Vietnam, April 4, 1966.

Air Force Operations

Bob Schieffer Vietnam War Collection

Daily summary of the Navy Air Force's Seventh Fleet in Vietnam, April 4, 1966.

Military Operations

Bob Schieffer Vietnam War Collection

Reporting of events that occurred during Operation Jack Stay in Vietnam, April 4, 1966.

James White’S First Stroke And Rising Tension Between Adventist Leaders, Kevin M. Burton

Ellen White Issues Symposium

No abstract provided.

The Chinese Reception Of Ellen G. White, Christie Chui-Shan Chow

Ellen White Issues Symposium

No abstract provided.

Desire And Worship In The Desire Of Ages, David A. Williams

Ellen White Issues Symposium

No abstract provided.

Plurality Of Unfallen Worlds: Ellen White And Extraterrestrials, Jud Lake

Ellen White Issues Symposium

No abstract provided.

The Holy Spirit As A Representative Of Christ In Ellen G. White’S Writings, Denis Kaiser

Ellen White Issues Symposium

No abstract provided.

Critical Assessments Of The Bible And The Writings Of Ellen G. White, Alberto R. Timm

Ellen White Issues Symposium

No abstract provided.

Ellen G. White On The “Deeper Meaning” Of Scripture, Alberto R. Timm

Ellen White Issues Symposium

No abstract provided.

Marketcrafters: The 100-Year Struggle To Shape The American Economy, Jay Nathan

Journal of Global Awareness

No abstract provided.

Trustworthy Ai: Prohibited Practices, Ethical Principles, And The Identification Of Problems, Anna Karmańska

Journal of Global Awareness

The following considerations arise from the study of texts of documents of a legal nature and from the author’s judgments. They do not present the results of the author’s own empirical research; however, they constitute a factual study that is important for their undertaking in the next step. Having given concern but also hopes for AI, the author focuses her attention on issues that, not only in her opinion, have a strong bearing on the preservation of humanity in a digital environment and at the same time with technocratic features. These issues (prohibited practices, high-risk systems, and ethics) related to …

Music And Sustainable Development Goals: Telling The Story, Mark Reimer

Journal of Global Awareness

Now, 10 years after the United Nations adopted its 17 Sustainable Development Goals, the music profession continues to work toward being a responsible partner in the health and preservation of the planet and its inhabitants. By transcending social barriers, music promotes cultural awareness and mutual understanding, encourages creativity, and enhances emotional well-being, outcomes vital to the global goals of health, freedom, peace, education, equality, prosperity, and environmental sustainability. The article includes various examples of how music performers, educators, composers, and scholars are creating or adopting new practices that are mindful of reducing the carbon footprint, yet financially feasible in their …

Economic Development And Its Transformation In Happiness: A Perspective Of Sustainable Development Goals Of Nepal, Dhruba Bhattarai, Bishnu Bhattarai

Journal of Global Awareness

The present paper attempts to explore the relationship between GDP Per Capita Income based economic measurements of people’s well-being in the form of happiness. The overall development of a country’s economy must be translated into people’s well-being and happiness, which the study focuses on using the relevant data. The secondary data of the Human Development Index, Gross Domestic Product, Per Capita Income, and Happiness Index for the last 20 years have been collected and analyzed. To assess the psychological aspects of the happiness concept, the relevant happiness indicators such as life expectancy, educational attainment, and index of economic freedom have …

Effects Of External Debt On Inflation In The West African Monetary Zone (Wamz), Collins Anosike

Journal of Global Awareness

This research examined the effect of external public debt on inflation in the West African Monetary Zone (WAMZ) using annual data from 1960 to 2022. The study selected the six member countries of WAMZ, namely: Gambia, Guinea, Nigeria, Sierra Leone, Liberia, and Ghana, to examine their economic well-being, growth performance, external debt, and inflation over a 63-year period. This study is unique because it examines three periods, namely: pre-WAMZ (1960 to 2000); during WAMZ (2001 to 2022); and the entire period (1960 to 2022), extends previous studies by using updated data, and then shows the long-run positive effect of external …

Notes From The Editor, Jay Nathan

Journal of Global Awareness

No abstract provided.

Letter From The Editor, Jay Nathan

Journal of Global Awareness

No abstract provided.

Ellen White’S Usage Of The Term Plain In The Context Of The Interpretation Of Scripture, Iriann Marie Hausted

Ellen White Issues Symposium

No abstract provided.

Hermeneutics Of Ellen G. White’S Writings: Basic Rules Of Interpretation, Jiři Moskala

Ellen White Issues Symposium

No abstract provided.