Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Law (431952)
- Social and Behavioral Sciences (403762)
- Arts and Humanities (290125)
- Education (235125)
- Medicine and Health Sciences (203502)
-
- Life Sciences (117143)
- Physical Sciences and Mathematics (115641)
- History (114523)
- Business (107466)
- Engineering (82882)
- Higher Education (77719)
- Communication (73605)
- Sociology (65451)
- Public Affairs, Public Policy and Public Administration (63131)
- Public Health (55742)
- Library and Information Science (53178)
- Religion (50267)
- Medical Specialties (46130)
- United States History (45940)
- Psychology (45502)
- Journalism Studies (35094)
- Political Science (34567)
- Accounting (34265)
- Mass Communication (32987)
- Economics (32879)
- Social History (31728)
- Educational Administration and Supervision (31419)
- Environmental Sciences (30757)
- Computer Sciences (30099)
- Constitutional Law (29649)
- Institution
-
- University of New Mexico (85710)
- University of Montana (66867)
- University of Mississippi (65979)
- University of South Florida (62448)
- University of New Hampshire (62222)
-
- University of Nebraska - Lincoln (60132)
- Utah State University (47140)
- Brigham Young University Law School (42635)
- University of Colorado Law School (35096)
- Georgia Southern University (32683)
- Brigham Young University (31008)
- San Jose State University (27892)
- University of Central Florida (27571)
- Eastern Illinois University (26947)
- California Polytechnic State University, San Luis Obispo (26526)
- University of Kentucky (26340)
- Murray State University (26115)
- University of North Dakota (23547)
- Washington University School of Medicine (23266)
- University of Dayton (22816)
- Purdue University (21929)
- Louisiana State University (21663)
- City University of New York (CUNY) (20662)
- Western Michigan University (20599)
- Western Kentucky University (19832)
- The Texas Medical Center Library (18775)
- University of Michigan Law School (18684)
- Portland State University (18423)
- University of South Carolina (18376)
- Walden University (18114)
- Keyword
-
- Newspaper (44672)
- Press release; media release; press statement; news media information (30839)
- Humans (22198)
- Education (21082)
- Student newspaper (17992)
-
- Newspapers (16984)
- History (16604)
- United States (13846)
- Newsletter (13249)
- COVID-19 (12269)
- Spartan Daily (12028)
- Higher education (11730)
- EIU (11367)
- Bowling Green State University (11262)
- Female (10839)
- Faculty (10156)
- Michigan (9901)
- Latin America (9788)
- Students (9601)
- Eastern Illinois University (9577)
- Pennsylvania (9571)
- Daily Eastern News (9422)
- Periodicals (9145)
- Male (9133)
- Spanish (9044)
- Collegeville (8872)
- BG News (8848)
- Student newspapers (8472)
- University of New Mexico (8455)
- Western Kentucky University (8421)
- Publication Year
-
- 2026 (61200)
- 2025 (88384)
- 2024 (100769)
- 2023 (91552)
- 2022 (93096)
-
- 2021 (96060)
- 2020 (93619)
- 2019 (90593)
- 2018 (89286)
- 2017 (88507)
- 2016 (87723)
- 2015 (82149)
- 2014 (76920)
- 2013 (73786)
- 2012 (73381)
- 2011 (62333)
- 2010 (59769)
- 2009 (55795)
- 2008 (51274)
- 2007 (46416)
- 2006 (44816)
- 2005 (40980)
- 2004 (38292)
- 2003 (35538)
- 2002 (33790)
- 2001 (32115)
- 2000 (30978)
- 1999 (28232)
- 1998 (27622)
- 1997 (26655)
- Publication
-
- Theses and Dissertations (50348)
- University of Montana News Releases, 1928, 1956-present (30909)
- Faculty Publications (27329)
- Electronic Theses and Dissertations (21003)
- Faculty Scholarship (20590)
-
- Dissertations (17890)
- Walden Dissertations and Doctoral Studies (16609)
- Articles (14224)
- Session Laws 1951-2000 (13139)
- Open Access Publications (11655)
- Theses (11541)
- Spartan Daily (School of Journalism and Mass Communications) (11107)
- Daily Mississippian (all digitized issues) (10882)
- Masters Theses (10072)
- Documents (9842)
- Montana Kaimin, 1898-present (9454)
- Faculty, Staff and Student Publications (9450)
- African American Funeral Programs (9159)
- BG News (Student Newspaper) (8960)
- All Graduate Theses and Dissertations, Spring 1920 to Summer 2023 (8856)
- Michigan Law Review (8522)
- Utah Supreme Court Briefs (1965 –) (8082)
- Santa Fe New Mexican, 1883-1913 (8047)
- Master's Theses (7956)
- Honors Theses (7651)
- 2020-Current year OA Pubs (7468)
- WKU Administration Documents (7412)
- News Releases (7291)
- USF Tampa Graduate Theses and Dissertations (7079)
- Doctoral Dissertations and Projects (7025)
- Publication Type
Articles 47641 - 47670 of 2914934
Full-Text Articles in Entire DC Network
No. 110 An Order To Provide Relief In Anticipation Of Severe Winter Weather, Bill Lee
No. 110 An Order To Provide Relief In Anticipation Of Severe Winter Weather, Bill Lee
Executive Orders
No abstract provided.
Nitroarene-Mediated Photo-Oxidative Deconstruction And Upcycling Of Unsaturated Rubber Waste, Junpeng Wang, Zefeng Wang, Roberto Obergon, Obed Fernando
Nitroarene-Mediated Photo-Oxidative Deconstruction And Upcycling Of Unsaturated Rubber Waste, Junpeng Wang, Zefeng Wang, Roberto Obergon, Obed Fernando
University Research
Transforming waste polymers into materials with improved properties offers a compelling strategy for advancing the sustainable use of polymers, echoing the Chinese proverb: “Blue comes from indigo but surpasses it in blueness.” Herein, we report a photo-oxidative deconstruction and upcycling method for unsaturated rubber waste. Under 390 nm LED irradiation at room temperature, in the presence of a nitroarene oxidant, diverse unsaturated polymers─including natural rubber, polybutadiene, nitrile rubber, styrene–butadiene rubber, and even cross-linked nitrile gloves─are selectively converted into carbonyl-terminated oligomers. The aldehyde-functionalized products are cross-linked via dynamic imine chemistry with p-phenylenediamine to yield reprocessable elastomers with markedly improved tensile strength …
Obesity And Long Covid: Intersecting Epidemics?, Michael Gottlieb, Huihui Yu, Ji Chen, Erica S. Spatz, Nicole L. Gentile, Rachel E. Geyer, Michelle Santangelo, Caitlin Malicki, Kristyn Gatling, Kelli N. O'Laughlin, Kari A. Stephens, Joann G. Elmore, Lauren E. Wisk, Michelle L'Hommedieu, Robert M. Rodriguez, Juan Carlos C. Montoy, Ralph C. Wang, Kristin L. Rising, Efrat Kean, Jonathan W. Dyal, Mandy J. Hill, Arjun K. Venkatesh, Robert A. Weinstein, Inspire Group
Obesity And Long Covid: Intersecting Epidemics?, Michael Gottlieb, Huihui Yu, Ji Chen, Erica S. Spatz, Nicole L. Gentile, Rachel E. Geyer, Michelle Santangelo, Caitlin Malicki, Kristyn Gatling, Kelli N. O'Laughlin, Kari A. Stephens, Joann G. Elmore, Lauren E. Wisk, Michelle L'Hommedieu, Robert M. Rodriguez, Juan Carlos C. Montoy, Ralph C. Wang, Kristin L. Rising, Efrat Kean, Jonathan W. Dyal, Mandy J. Hill, Arjun K. Venkatesh, Robert A. Weinstein, Inspire Group
Jefferson Center for Connected Care Faculty Papers
BACKGROUND: Obesity affects over 10% of the world population and has significant public health implications. With rising recognition of the long-term effects of Long COVID (LC) coupled with new agents to facilitate weight loss, it is critical to understand the influence of obesity on LC. This study assessed the association of obesity with rates of LC and degree of LC-related mental and physical health outcomes among participants up to three years after initial infection.
METHODS: This was a cross-sectional, multisite study of participants with SARS-CoV-2 infection from 12/11/2020–8/29/2022, with data collected through 4/2/2024. Surveys included validated tools for physical and …
Operating On Thin Margins: The Cost Of Providing New Hampshire Child Care, Tyrus Parker, Jess Carson
Operating On Thin Margins: The Cost Of Providing New Hampshire Child Care, Tyrus Parker, Jess Carson
Carsey Publications
In this primer, authors Tyrus Parker and Jess Carson summarize available data on the cost of operating a child care program in New Hampshire. Using data from a 50-state cost calculator as well as three local child care programs, the authors find that despite high child care costs for families, tuition alone is largely insufficient revenue for program operation. As a result, child care program operators must make difficult tradeoffs around program offerings, program quality, and compensation for educators. The authors call for rigorous data collection and modeling to support planning a sustainable financial model for the Granite State’s early …
Strategies Financial Institutions Use To Mitigate Security Breaches For Mobile Customers, Steven F. Knese
Strategies Financial Institutions Use To Mitigate Security Breaches For Mobile Customers, Steven F. Knese
Walden Dissertations and Doctoral Studies
Mobile fraud attack rates are increasing rapidly. Financial institutions, cybersecurity managers, and regulators need effective strategies to reduce consumer financial harm and operational risk. Grounded in the cybernetics model, this qualitative, pragmatic inquiry identified the cybersecurity strategies that cybersecurity professionals use at financial institutions to mitigate data breaches for mobile customers accessing financial data. Data were collected from five cybersecurity professionals through semistructured interviews and from publicly available documents and guidance issued by financial institutions and standards bodies. Six significant themes emerged from thematic analysis: implementing multifactor authentication, deploying virtual private networks (VPNs), delivering user education, promoting regular account monitoring, …
Hiv Pre-Exposure Prophylaxis Uptake And Continuation Among 15-24-Year-Old Women In Mulago, Uganda, Dithan Kiragga
Hiv Pre-Exposure Prophylaxis Uptake And Continuation Among 15-24-Year-Old Women In Mulago, Uganda, Dithan Kiragga
Walden Dissertations and Doctoral Studies
Young women in Uganda face disproportionately high HIV risk compared to the general population. While pre-exposure prophylaxis (PrEP) demonstrates proven effectiveness, poor uptake and nonadherence limit its potential impact. This study examined the relationship between perceived HIV susceptibility, PrEP benefits, behavioral risk factors, service delivery models, and PrEP uptake and continuity among young women aged 15–24 in Uganda, guided by the health belief model. Data were ed from surveillance records at Mulago National Referral Hospital’s STI clinic from January 2024 to September 2025. Of N=23,765 young women screened (median age 21 years; 98.9% single or separated; 48.7% with primary education), …
Association Between The 2022 Aha/Acc/Hfsa Heart Failure Staging And Cardiovascular And Kidney Outcomes In Patients With Diabetes And Kidney Disease: A Post Hoc Analysis Of The Scored Randomized Controlled Trial, Ayodele Odutayo, Deepak L Bhatt, Vikas S Sridhar, Michael Szarek, Christopher P Cannon, Lawrence A Leiter, Darren K Mcguire, Julia B Lewis, Renato D Lopes, Benjamin M Scirica, Kausik K Ray, Michael J Davies, Phillip Banks, Manon Girard, Subodh Verma, Jacob A Udell, Bertram Pitt, Ph Gabriel Steg, David Z I Cherney
Association Between The 2022 Aha/Acc/Hfsa Heart Failure Staging And Cardiovascular And Kidney Outcomes In Patients With Diabetes And Kidney Disease: A Post Hoc Analysis Of The Scored Randomized Controlled Trial, Ayodele Odutayo, Deepak L Bhatt, Vikas S Sridhar, Michael Szarek, Christopher P Cannon, Lawrence A Leiter, Darren K Mcguire, Julia B Lewis, Renato D Lopes, Benjamin M Scirica, Kausik K Ray, Michael J Davies, Phillip Banks, Manon Girard, Subodh Verma, Jacob A Udell, Bertram Pitt, Ph Gabriel Steg, David Z I Cherney
Faculty, Staff and Student Publications
Background: The 2022 American Heart Association/American College of Cardiology/Heart Failure Society of America heart failure (HF) classification incorporates cardiac biomarkers to identify early risk of HF. The HF stages may also guide the prognosis and management of cardiovascular and kidney-related events.
Methods: SCORED (Effect of Sotagliflozin on Cardiovascular and Renal Events in Patients With Type 2 Diabetes and Moderate Renal Impairment Who Are at Cardiovascular Risk) was a randomized trial in diabetes with kidney disease comparing sotagliflozin versus placebo on cardiovascular death, HF hospitalizations, and urgent HF visits. SCORED participants were grouped by HF stage post hoc. Stage A: no …
The Gene Encoding Ornithine Decarboxylase For Putrescine Biosynthesis Is Essential For The Viability Of Fusobacterium Nucleatum, Shiqi Xu, Bibek G C, Alex Phan, Chenggang Wu
The Gene Encoding Ornithine Decarboxylase For Putrescine Biosynthesis Is Essential For The Viability Of Fusobacterium Nucleatum, Shiqi Xu, Bibek G C, Alex Phan, Chenggang Wu
Faculty, Staff and Student Publications
Fusobacterium nucleatum is a Gram-negative anaerobe associated with periodontitis and colorectal cancer. It secretes putrescine, a polyamine that promotes biofilm formation by oral co-colonizers and enhances the proliferation of cancer cells. However, the physiological importance of putrescine for F. nucleatum itself remains unexplored. Here, we show that putrescine biosynthesis, mediated by the ornithine decarboxylase gene oda, is essential for F. nucleatum viability. Deletion of oda was only possible when a functional copy was provided in trans, and CRISPR interference of oda expression resulted in complete growth defects. The essentiality of oda was conserved across multiple subspecies. Supplementation with …
Disease-Specific And Overall Survival For Patients With Lacrimal Gland Adenoid Cystic Carcinoma In Recent Decades, Bita Esmaeli, Zhouxuan Li, Tracy J Lu, Hila Goldberg, Jing Ning, James Matthew Debnam, Steven Jay Frank, Renata Ferrarotto
Disease-Specific And Overall Survival For Patients With Lacrimal Gland Adenoid Cystic Carcinoma In Recent Decades, Bita Esmaeli, Zhouxuan Li, Tracy J Lu, Hila Goldberg, Jing Ning, James Matthew Debnam, Steven Jay Frank, Renata Ferrarotto
Faculty, Staff and Student Publications
Purpose: To evaluate the presenting symptoms, and the overall survival (OS) and disease-specific survival (DSS) in patients with lacrimal gland adenoid cystic carcinoma (LGACC).
Methods: This retrospective single-centre cohort study included all consecutive patients with LGACC treated by the primary author from November 1998 through August 2024. Demographic data, presenting symptoms, the histological subtype of LGACC, type of surgical treatment, adjuvant radiotherapy or chemotherapy, T category at presentation and survival data were reviewed. Correlations between histological subtypes, T-category, type of surgery (eye sparing vs orbital exenteration), and DSS and OS were analysed.
Results: 52 patients had a median age of …
Utah Women In The Workplace: Entrepreneurship, Workforce Development, Stem Fields, And Leadership Development, Susan R. Madsen, April Townsend
Utah Women In The Workplace: Entrepreneurship, Workforce Development, Stem Fields, And Leadership Development, Susan R. Madsen, April Townsend
Marketing and Strategy Faculty Publications
During the fall of 2023, Utah Women & Leadership Project (UWLP) researchers conducted a statewide study to establish a baseline for public perceptions related to the awareness, understanding, and attitudes about challenges that Utah women and girls face. In early 2024, we published 20 short research summaries1 that shared the results of this comprehensive study (see Nos. 9–28). Next, in the fall of 2024, we administered this survey, with slight changes, around the state of Utah for the second time. Six comprehensive research white papers were then published on the results (see Nos. 11, 12, 13, 14, 16, and …
Public Speaking, Demonstration And Action Exhibit Scorecard & Information, Alison Coleman
Public Speaking, Demonstration And Action Exhibit Scorecard & Information, Alison Coleman
UNH Cooperative Extension
No abstract provided.
Subjective Perspectives On Antarctic Wilderness: An Application Of Integral Ecology, Annabelle G. Mayes
Subjective Perspectives On Antarctic Wilderness: An Application Of Integral Ecology, Annabelle G. Mayes
Honors College Theses
Parties to the Antarctic Treaty have set Antarctica aside for peace, scientific research, and environmental protection. However, they have yet to take concrete actions to protect Antarctica’s wilderness values as agreed under the 1991 Protocol on Environmental Protection to the Antarctic Treaty. Meanwhile, pristine areas that are free from human interference are declining as human activity escalates. This study examines perceptions of Antarctic wilderness through the lens of integral ecology. Data from 1,640 people and 16 study populations were extracted from four published studies. Content analysis was conducted to determine how subjective perspectives differ across populations and geographic regions. All …
Ksu Chamber Singers: Gmea Send Off Concert
Ksu Chamber Singers: Gmea Send Off Concert
Bailey School of Music Concert Programs
with the Harrison High School Chamber Singers
Targeting Smpdl3b To Ameliorate Radiation- And Cisplatin-Induced Renal Toxicity, Youssef Zeidan
Targeting Smpdl3b To Ameliorate Radiation- And Cisplatin-Induced Renal Toxicity, Youssef Zeidan
All Publications
Kidney toxicity remains a major dose-limiting complication of radiation therapy and platinum-based chemotherapy, yet the molecular determinants of renal susceptibility and resilience to these genotoxic treatments are incompletely understood. Podocytes are particularly vulnerable to such insults, and emerging evidence implicates lipid dysregulation in podocyte injury. This study investigated the role of sphingomyelin phosphodiesterase acid-like 3B (SMPDL3B), a podocyte-enriched lipid-modulating enzyme, in radiation- and cisplatin-induced nephrotoxicity. Using a doxycycline-inducible, podocyte-specific SMPDL3B transgenic mouse model, renal injury was assessed following focal kidney irradiation, cisplatin administration, or their combination through functional assays, histopathology, ultrastructural analysis, immunofluorescence, and targeted lipidomics. Combined radiation and cisplatin …
Spartan Daily, January 22, 2026, San Jose State University, School Of Journalism And Mass Communications
Spartan Daily, January 22, 2026, San Jose State University, School Of Journalism And Mass Communications
Spartan Daily, 2026
Volume 166, Issue 1
Spurious Elevations Of Chromogranin A In The Setting Of Autoimmune Metaplastic Atrophic Gastritis, Elizabeth Jose, Ariana Ambrosio, Jesse F. Simon, Jeffrey H. Schneider
Spurious Elevations Of Chromogranin A In The Setting Of Autoimmune Metaplastic Atrophic Gastritis, Elizabeth Jose, Ariana Ambrosio, Jesse F. Simon, Jeffrey H. Schneider
Student Publications
Autoimmune metaplastic gastritis (AMAG) is a form of autoimmune gastritis that is characterized by the immune system’s attack on gastric parietal cells, leading to chronic inflammation. Gastric neuroendocrine tumors (GNETs) are rare neoplasms that can develop in the gastrointestinal tract in the presence of AMAG. This case presents a 69-year-old female who presented with dyspepsia, and on subsequent endoscopic evaluation, she was found to have AMAG in the context of elevated levels of serum chromogranin A (CgA) and gastrin, suggestive of a GNET. Despite an extensive diagnostic workup, including imaging, colonoscopy, small bowel follow-through, capsule study, and oncology workup, no …
An Ai Tool Recreates Some Of The Friction Of Academic Search. Is That Actually Helpful?, Jasmine S. Kirby
An Ai Tool Recreates Some Of The Friction Of Academic Search. Is That Actually Helpful?, Jasmine S. Kirby
Libraries Faculty & Staff Publications
Keenious mitigates some of the educational risks of AI search. But its limitations will frustrate some users.
Saudi Arabia And Türkiye ‘S Policy Towards Hamas: Between Pragmatism And Regional Geo-Political Balance, Mulawarman Hannase, Syaiful Rohman
Saudi Arabia And Türkiye ‘S Policy Towards Hamas: Between Pragmatism And Regional Geo-Political Balance, Mulawarman Hannase, Syaiful Rohman
Jurnal Wacana Politik
This paper examines the foreign policies of Saudi Arabia and Türkiye towards Hamas. This Islamist group has become a major actor in the Palestinian-Israeli conflict in the past decade. This article aims to analyze the two countries’ different approaches in addressing Hamas by capturing the political, ideological, and regional geopolitical factors at play. Using a qualitative approach and desk study method, data is obtained by analyzing official documents, diplomatic statements, and academic literature. The results of the study show that Saudi Arabia tends to keep its distance from Hamas due to its affiliation with the Muslim Brotherhood and concerns over …
University Medical City Annual Research Day Oman, Convention And Exhibition Centre, 24Th September 2025, Sultan Qaboos University
University Medical City Annual Research Day Oman, Convention And Exhibition Centre, 24Th September 2025, Sultan Qaboos University
Sultan Qaboos University Medical Journal
No abstract provided.
The Effect Of Fluorides In The Tio2(B) Anode On The Hydrogen Evolution Reaction In Aqueous Electrolytes, Khoi-Nguyen Nguyen, Lam Hoang Nguyen, Jozel John Salvacion, Nam Huu Nhat Nguyen, Samuel Ming Tuk Yeung, Seung Woo Lee, Liat Rosenfeld, Chengyu Song, Dahyun Oh
The Effect Of Fluorides In The Tio2(B) Anode On The Hydrogen Evolution Reaction In Aqueous Electrolytes, Khoi-Nguyen Nguyen, Lam Hoang Nguyen, Jozel John Salvacion, Nam Huu Nhat Nguyen, Samuel Ming Tuk Yeung, Seung Woo Lee, Liat Rosenfeld, Chengyu Song, Dahyun Oh
Faculty Research, Scholarly, and Creative Activity
For aqueous lithium-ion batteries (A-LIBs), the hydrogen evolution reaction (HER) poses a significant challenge, as it competes with the primary electrochemical processes of the anode, resulting in capacity loss and reduced cycling stability. In this study, we investigate the use of fluorine-based additives in anodes to mitigate HER in LIBs with aqueous electrolytes including low or high amounts of salt (water-in-salt electrolytes (WiSE)). We synthesized and incorporated three distinct materials into TiO2(B) anodes: aluminum fluoride (AlF3), lithium fluoride (LiF), and 1H,1H,2H, 2H-perfluorooctyltriethoxysilane (FAS) using a solution-based method. Among these fluorides containing composite anodes, FAS containing anodes delayed HER onset potentials …
The Gut Microbiota Shapes The Human And Murine Breath Volatilome, Ariel J. Hernandez-Leyva, Amalia Z. Berna, Maggie H. Bui, Yang Liu, Anne L. Rosen, Michael A. Lint, Samantha A. Whiteside, Natalia Jaeger, Nikhilesh Joardar, Wentai Luo, Multiple Additional Authors
The Gut Microbiota Shapes The Human And Murine Breath Volatilome, Ariel J. Hernandez-Leyva, Amalia Z. Berna, Maggie H. Bui, Yang Liu, Anne L. Rosen, Michael A. Lint, Samantha A. Whiteside, Natalia Jaeger, Nikhilesh Joardar, Wentai Luo, Multiple Additional Authors
Chemistry Faculty Publications and Presentations
The gut microbiota is crucial to health, yet implementation of microbiota-based therapeutics is limited by the lack of rapid diagnostics. We hypothesize that breath contains gut microbe-derived volatile organic compounds (VOCs) reflecting microbiota composition and metabolism. In healthy children, we found that breath VOC composition (or volatilome), assessed by gas chromatography-mass spectrometry, correlates with gut microbiome composition and function. By capturing exhaled breath from human-stool-colonized and monocolonized gnotobiotic mice, we profiled breath VOCs and discovered that murine breath is also significantly influenced by the gut microbiome. VOCs from cultured gut microbes were identified in vivo in monocolonized gnotobiotic colonized mice. …
Evaluation Of Adalimumab Tapering Regimens In Children And Adolescents With Juvenile Idiopathic Arthritis In Remission: A Simulation Study, Dominic S Bräm, Verena Gotta, Gilbert Koch, Klervi Golhen, Andreas Woerner, Andrew Atkinson, Johannes N Van Den Anker, Marc Pfister, Tatjana Welzel
Evaluation Of Adalimumab Tapering Regimens In Children And Adolescents With Juvenile Idiopathic Arthritis In Remission: A Simulation Study, Dominic S Bräm, Verena Gotta, Gilbert Koch, Klervi Golhen, Andreas Woerner, Andrew Atkinson, Johannes N Van Den Anker, Marc Pfister, Tatjana Welzel
2020-Current year OA Pubs
BACKGROUND: Adalimumab (ADM) in children with juvenile idiopathic arthritis (JIA) is usually dosed using fixed weight-based bands (label dosing: 20 mg for < 30 kg, 40 mg for ≥ 30 kg) every other week (EOW). This has been shown to result in higher exposure after remission than targeted in adult patients with rheumatic diseases (trough concentrations of 2–8 mg/L) suggesting possibility of treatment adjustments and tapering, particularly in children weighing 30 to 50 kg. A pharmacometric simulation study was performed to evaluate different ADM dosing regimens supported by therapeutic drug monitoring (TDM) to provide insights for JIA management in remission. METHODS: This simulation study used a previously established pharmacokinetic ADM model. Simulation scenarios included dose reduction to 30 mg in children 30 to 50 kg and interval extension from 14 to 21 or 28 days. To further personalize ADM dosing and avoid exposure above predefined target range, TDM-guided tapering within mentioned simulation scenarios was investigated, i.e., adjusting dosing interval in children and adolescents whose ADM trough concentrations were above the upper limit of the predefined ADM target range of 9 mg/L. Proportions of virtual patients within the extrapolated target exposure range from adults including a safety-margin, i.e., 4–9 mg/L, were assessed and compared to label dosing, stratified by body weight. RESULTS: In children and adolescents with JIA weighing 30 to 50 kg both, dose interval extension to 21 days and dose reduction to 30 mg EOW increased proportion of patients within predefined target range from 17 - 29% (label dose regimen) to 34–43% or 28–43%, respectively. TDM-guided tapering for patients with trough concentrations > 9 mg/L further increased proportion with target exposure to 56–63% while keeping the proportion of patients with trough concentrations < 2 mg/L similar to label dosing (≤ 2%). CONCLUSION: This simulation study suggests that ADM tapering, in children with JIA who reached remission, may be applicable. Appropriate ADM dose reduction or dose interval extension, especially when supported by TDM, could help to reduce treatment-related and socioeconomic burden, while minimize risk of underexposure. Provided simulation framework can be validated and further fine-tuned once paediatric exposure-response data and target ranges have been established.
Phase 1b/2 Study Of Bms-813160, A Ccr2/5 Dual Antagonist, In Combination With Chemotherapy Or Nivolumab In Patients With Advanced Pancreatic Or Colorectal Cancer, Dung T Le, Nikolaos A Trikalinos, Et Al.
Phase 1b/2 Study Of Bms-813160, A Ccr2/5 Dual Antagonist, In Combination With Chemotherapy Or Nivolumab In Patients With Advanced Pancreatic Or Colorectal Cancer, Dung T Le, Nikolaos A Trikalinos, Et Al.
2020-Current year OA Pubs
BACKGROUND: Cysteine-cysteine chemokine receptors 2 (CCR2) and 5 (CCR5) contribute to immune suppression in tumor microenvironments. CCR2 and CCR5 antagonists have demonstrated antitumor activity in pancreatic ductal adenocarcinoma (PDAC) and colorectal cancer (CRC), respectively. This phase 1b/2, open-label study evaluated BMS-813160, a CCR2/5 dual antagonist, in combination with chemotherapy±nivolumab in advanced PDAC or metastatic CRC.
METHODS: Part 1 included patients with metastatic untreated (first-line (1L)) PDAC, 1L CRC, or previously treated (second or third line (2/3L)) microsatellite stable (MSS) CRC. Patients received 2 weeks of BMS-813160 monotherapy (300 mg two times a day, 600 mg once daily, 300 mg once …
The Analysis Of Complete Basic Immunization Low Coverage During Covid-19 Pandemic At Community Health Center Pekanbaru, Nuzul Rifqa Sahira
The Analysis Of Complete Basic Immunization Low Coverage During Covid-19 Pandemic At Community Health Center Pekanbaru, Nuzul Rifqa Sahira
Jurnal Vokasi Indonesia
Complete Basic Immunization (IDL) is the giving of early immunization to infants before their age below one year old consisting of Hepatitis B, BCG, DPT-HB-Hib, Polio (IPV and OPV) and measles. Giving Immunization to children can prevent the occurrence of disease transmission (PD3I). The lowest IDL coverage in Pekanbaru Community Health Center during the Covid-19 pandemic experienced a significant decrease of 58.1%. The study objective was to analyze low IDL coverage in infants during the Covid-19 pandemic. The method was qualitative with phenomenology design. The study informant was 11 people. Data collection was conducted through in-deep interview, observation and document …
Holistic Wellness Frameworks In Higher Education: A Systematic Review Of Impact On Student Well-Being And Academic Outcomes, Charles Rettig
Holistic Wellness Frameworks In Higher Education: A Systematic Review Of Impact On Student Well-Being And Academic Outcomes, Charles Rettig
Pacific Journal of Health
Objective: To examine the impact of holistic wellness frameworks on undergraduate students’ well-being, academic performance (GPA), and graduation rates, and to understand student perceptions and engagement factors with programs in higher education.
Background: Undergraduate students face increasing issues like mental health challenges, sleep deprivation, and inadequate physical activity, which significantly impede academic potential and well-being. Although the military’s H2F framework successfully enhances readiness across five integrated pillars, a systematic exploration of a similarly crafted civilian program’s direct influence on student outcomes in higher education remains largely unaddressed.
Methods: A structured electronic search following PRISMA 2020 guidelines across PubMed, GoogleScholar, PacificScholar, …
Effects Of Oral Exams On Entry-Level Stem Mathematics Students, Krysten A. Pampel
Effects Of Oral Exams On Entry-Level Stem Mathematics Students, Krysten A. Pampel
International Journal of Teaching and Learning in Higher Education
This study investigates the efficacy of oral examinations as an alternative assessment method in college algebra courses, focusing on their impact on student retention of mathematical concepts. Through a comparative analysis of two groups, one undergoing traditional assessment and the other receiving oral examinations, this research explores both quantitative assessment scores and qualitative feedback. While quantitative analysis reveals no significant difference in summative assessment performance between the two groups, qualitative data highlights the benefits of oral examinations, including immediate feedback, enhanced critical thinking, and holistic evaluation of student capabilities. Despite limitations in sample size, the study suggests that oral examinations …
The Value Of Unsiloing Yourself: Cycle Of Inquiry & Tackling Hard Questions In Community, Allyson Bogie, Mia Gittlen, Meredith Irby, Sam Solomon, Sarah Sugarman
The Value Of Unsiloing Yourself: Cycle Of Inquiry & Tackling Hard Questions In Community, Allyson Bogie, Mia Gittlen, Meredith Irby, Sam Solomon, Sarah Sugarman
High School Libraries Workshop
No abstract provided.
Political Posters, Periperformativity, And Power: An Analysis Of The Connections Between An Activist Movement’S Image And Sound, Adeline Navarro
Political Posters, Periperformativity, And Power: An Analysis Of The Connections Between An Activist Movement’S Image And Sound, Adeline Navarro
Acta Cogitata: An Undergraduate Journal in Philosophy
This essay aims to reconcile a gap in scholarship on the AIDS crisis as prior scholars have looked at ACT UP’s image, only recently focusing on their sound. First, this essay argues that we can gain a better understanding of the relationship between ACT UP’s image and sound, specifically its political posters and subsequent chants, by using Eve Kosofsky Sedgwick’s theory of periperformativity to examine the periperformative dimension of these chants and thus the power they lend ACT UP members during civil disobedience demonstrations. Second, it argues that the periperformative has the capacity to register historical change because it is …
Restorative Justice, Human Dignity, And The Capabilities Approach, Reed Mcfeely
Restorative Justice, Human Dignity, And The Capabilities Approach, Reed Mcfeely
Acta Cogitata: An Undergraduate Journal in Philosophy
As a value-driven and transformative approach to criminal justice, restorative justice is inherently philosophical. Despite this, however, its philosophical underpinnings remain underdeveloped. This manuscript argues for the necessity of grounding restorative justice in moral philosophy, specifically through the framework offered by Martha Nussbaum’s capabilities approach. The paper first addresses the fragmented nature of restorative justice values, suggesting a new uniform framework centered on respect, equality, agency, and active striving. It then explores what victims are materially owed in the restorative justice process, advancing Nussbaum’s list of basic capabilities as a foundation. However, the central aim of this manuscript transcends these …
The Experience Of U.S. Fulbright Scholars From Business Disciplines: 1998 – 2005
The Experience Of U.S. Fulbright Scholars From Business Disciplines: 1998 – 2005
Journal of Economics and Finance Education
The Fulbright Scholar program provides a long-standing and externally-funded means for internationalizing college and university curriculum. Over the past decade there has been an increasing emphasis on internationalization among faculty, administration and accrediting agencies. This manuscript is drawn from survey data which examines self-reported experiences of recent Fulbright Scholars from business disciplines in AACSBI accredited business programs. An overview of the perceptions and experiences of program participants and an exploratory model identifying factors impacting these experience are presented. Specific policy and process measures to improve the experiences of future Fulbright Scholars are suggested.