Digital Commons Network^™

Reading Curriculum Policy And (Re)Shaping Practices: The Possibilities And Limits Of Enactment, Dawn Penney, Laura Alfrey

Research outputs 2022 to 2026

This paper provides a contribution and opening to the special issue Realising curriculum possibilities: From creative readings to transformative practice. It firstly considers and expands upon issues and concepts that were foregrounded in the special issue call for papers and that variously feature in subsequent contributions within it. Conceptual linkages that were implied or assumed in the text of the call for papers and that we contend, are worthy of continued debate and exploration, are critically examined. Enactment, creative readings, transformative practice and their inter-relationships are addressed. Secondly the paper provides an introduction that offers stimulus and provocation for the …

Show, Attend And Detect: Towards Fine-Grained Assessment Of Abdominal Aortic Calcification On Vertebral Fracture Assessment Scans, Syed Zulqarnain Gilani, Naeha Sharif, David Suter, John T. Schousboe, Siobhan Reid, William D. Leslie, Joshua R. Lewis

Research outputs 2022 to 2026

More than 55,000 people world-wide die from Cardiovascular Disease (CVD) each day. Calcification of the abdominal aorta is an established marker of asymptomatic CVD. It can be observed on scans taken for vertebral fracture assessment from Dual Energy X-ray Absorptiometry machines. Assessment of Abdominal Aortic Calcification (AAC) and timely intervention may help to reinforce public health messages around CVD risk factors and improve disease management, reducing the global health burden related to CVDs. Our research addresses this problem by proposing a novel and reliable framework for automated “fine-grained” assessment of AAC. Inspired by the vision-to-language models, our method performs sequential …

Activity Of Newest Generation Β-Lactam/Β-Lactamase Inhibitor Combination Therapies Against Multidrug Resistant Pseudomonas Aeruginosa, Robbie R. Haines, Papanin Putsathit, Katherine A. Hammer, Anna S. Tai

Research outputs 2022 to 2026

Multidrug resistant (MDR) P. aeruginosa accounts for 35 % of all P. aeruginosa isolated from respiratory samples of patients with cystic fibrosis (CF). The usefulness of β-lactam antibiotics for treating CF, such as carbapenems and later generation cephalosporins, is limited by the development of antibacterial resistance. A proven treatment approach is the combination of a β-lactam antibiotic with a β-lactamase inhibitor. New β-lactam/β-lactamase inhibitor combinations are available, but data are lacking regarding the susceptibility of MDR CF-associated P. aeruginosa (CFPA) to these new combination therapies. In this study we determined MIC values for three new combinations; imipenem-relebactam (I-R), ceftazidime-avibactam (CZA), …

Association Between Energy Balance-Related Factors And Clinical Outcomes In Patients With Ovarian Cancer: A Systematic Review And Meta-Analysis, Stephanie Stelten, Christelle Schofield, Yvonne A. W. Hartman, Pedro Lopez, Gemma G. Kenter, Robert U. Newton, Daniel A. Galvão, Meeke Hoedjes, Dennis R. Taaffe, Luc R. C. W. Van Lonkhuijzen, Carolyn Mcintyre, Laurien M. Buffart

Research outputs 2022 to 2026

Background:

This systematic review and meta-analysis synthesized evidence in patients with ovarian cancer at diagnosis and/or during first-line treatment on; (i) the association of body weight, body composition, diet, exercise, sedentary behavior, or physical fitness with clinical outcomes; and (ii) the effect of exercise and/or dietary interventions.

Methods:

Risk of bias assessments and best-evidence syntheses were completed. Meta-analyses were performed when ≥ 3 papers presented point estimates and variability measures of associations or effects.

Results:

Body mass index (BMI) at diagnosis was not significantly associated with survival. Although the following trends were not supported by the best-evidence syntheses, the meta-analyses …

Building The Plane While It’S Flying: Implementation Lessons From Integrating A Co-Located Exercise Clinic Into Oncology Care, Mary A. Kennedy, Sara Bayes, Robert U. Newton, Yvonne Zissiadis, Nigel A. Spry, Dennis R. Taaffe, Nicolas H. Hart, Daniel A. Galvão

Research outputs 2022 to 2026

Background:

Despite its therapeutic role during cancer treatment, exercise is not routinely integrated into care and implementation efforts are largely absent from the literature. The aim of this study was to evaluate a strategy to integrate the workflow of a co-located exercise clinic into routine care within a private oncology setting in two clinics in the metropolitan region of Western Australia.

Methods:

This prospective evaluation utilised a mixed methods approach to summarise lessons learned during the implementation of an integrated exercise workflow and supporting implementation plan. Data collection was informed by the RE-AIM (Reach, Effectiveness, Adoption, Implementation, Maintenance) framework. Reports …

Effect Of Carbon Fibres On Electromagnetic-Interference-Shielding Properties Of Geopolymer Composites, Dimuthu Wanasinghe, Farhad Aslani, Guowei Ma

Research outputs 2022 to 2026

Many of the construction materials available are known to cause a drastic level of damage to the environment during their manufacturing stages. Hence, many researchers have attempted to formulate construction materials that are more environmentally friendly. Additionally, the rise in wireless communications in recent decades has seen a rapid increase in electromagnetic pollution and interference, which affects the functionality of sensitive electronic devices. This research is focused on fabricating a more sustainable construction material that could prevent electromagnetic interference for electronic devices housed inside. Carbon fibres of three different lengths were added in four variations to a geopolymer control mix …

Effect Of Methyl Orange On Wettability Of Sandstone Formations: Implications For Enhanced Oil Recovery, Fatemah Alhamad, Mujahid Ali, Muhammad Ali, Hussein Abid, Hussein Hoteit, Stefan Iglauer, Alireza Keshavarz

Research outputs 2022 to 2026

With the increasing global population, fossil fuel resources still represent a main contributor to the energy supply, despite the progress made in the field of renewable energies. Large quantities of residual oil from mature reservoirs cannot be produced through primary and secondary recovery methods. Among alternative recovery techniques, chemically enhanced oil recovery methods are attracting considerable interest to increase the hydrocarbon recovery from oil-bearing geological formations. The wettability of any particular formation can be used to predict the oil recovery factor of a reservoir based on its wetting state. However, due to the complex nature of geological porous media, special …

Impact Of You Only Live Once: A Resilience-Based Hiv Prevention Intervention To Reduce Risky Sexual Behaviour Among Youth In South Africa, Fungai Mbengo, Esther Adama, Amanda Towell-Barnard, Arvin Bhana, Ebenezer Afrifa-Yamoah, Maggie Zgambo

Research outputs 2022 to 2026

Purpose: Interventions focused on promoting resilience or protective factors of youth have been proposed as a strategy for reducing risky behaviours associated with HIV infection among youth; however few studies have explored their effectiveness. This study assessed the impact of a resilience-based HIV prevention intervention (You Only Live Once) on risky sexual behaviours, resilience and protective factors of youth. Methods: A one-group pretest-posttest design was used. One hundred and ninety-seven youth aged 15 – 24 years were conveniently recruited from a non-profit organisation in Maluti-a-Phofung Local Municipality, South Africa and participated in a 12-session, resilience-based HIV intervention delivered over a …

Is The Precipitation Of Anxiety Symptoms Associated With Bolus Doses Of Flumazenil A Barrier To Its Use At Low Continuous Doses In Benzodiazepine Withdrawal?, Alexander Gallo, Tim Macdonald, Kellie Bennett, Gioiamia Basso-Hulse, Gary Hulse

Research outputs 2022 to 2026

Introduction:

Benzodiazepines (BZDs) are used in the management of anxiety and sleep disorders; however, chronic use is associated with tolerance and dependence. During withdrawal, symptoms of anxiety are often severe and problematic for patients and may lead to relapse or maintenance on low doses of BZDs. Low, continuous doses of flumazenil reduce BZD withdrawal symptoms in several studies; however, bolus doses are known to induce anxiety and precipitate panic. Accordingly, this study aimed to determine whether continuous low-dose flumazenil is anxiogenic like bolus doses.

Method:

In a randomised control cross over design, participants received a continuous low-dose flumazenil infusion for …

Mutual Effect Of Homocysteine And Uric Acid On Arterial Stiffness And Cardiovascular Risk In The Context Of Predictive, Preventive, And Personalized Medicine, Zhiyuan Wu, Haiping Zhang, Zhiwei Li, Haibin Li, Xinlei Miao, Huiying Pan, Jinqi Wang, Xiangtong Liu, Xiaoping Kang, Xia Li, Lixin Tao, Xiuhua Guo

Research outputs 2022 to 2026

Background:

Arterial stiffness is a major risk factor and effective predictor of cardiovascular diseases and a common pathway of pathological vascular impairments. Homocysteine (Hcy) and uric acid (UA) own the shared metabolic pathways to affect vascular function. Serum uric acid (UA) has a great impact on arterial stiffness and cardiovascular risk, while the mutual effect with Hcy remains unknown yet. This study aimed to evaluate the mutual effect of serum Hcy and UA on arterial stiffness and 10-year cardiovascular risk in the general population. From the perspective of predictive, preventive, and personalized medicine (PPPM/3PM), we assumed that combined assessment of …

Online Brand Detraction In An Online Opinion Platform, Violetta Wilk, Claire Lambert, Stephanie Meek

Research outputs 2022 to 2026

While most studies focus on positive consumer-driven brand outcomes, this study set out to understand a negative consumer-driven brand outcome - online brand detraction (OBD). Through the lens of social exchange theory, OBD was operationalized and compared to its direct opposite manifestation - online brand advocacy (OBA). A big data, qualitative analysis, with a longitudinal approach was used to understand OBD in an online opinion platform (OOP). Four key dimensions of OBD were found: brand negativity, brand attack, negative brand knowledge and experience sharing, and virtual visual cues. These dimensions are polar opposites of OBA - a highly sought-after organic …

The Slow Movements: Informetric Mapping Of The Scholarship And Implications For Tourism And Hospitality, Anton Klarin, Eerang Park, Sangkyun Kim

Research outputs 2022 to 2026

Slow food and the consequent slow movements are becoming more evident in research and media with the recognition of its implications for sustainability in many spheres of society. This study—the first systematic literature review of this topic—offers a comprehensive interdisciplinary investigation into slow movements which allows us to gain a systems view of the scholarship; stakeholder-oriented insights; and a holistic understanding of slowness while recognizing the various movements within and providing future research directions for tourism and hospitality researchers. This study identifies that slowness has extended to most aspects of our everyday life, such as the slow city, slow management, …

Airway Morphology And Its Influence On Osa Severity And Surgical Intervention: A Retrospective Study, Fabiana Petrykowski, Raymond Lam, Richard Lewis, Syed Mohammed Shamsul Islam, Mithran Goonewardene

Research outputs 2022 to 2026

Introduction: The aim was to assess the relationship between airway morphology and surgical intervention in a cohort of patients presenting with increased body mass index (BMI) and a confirmed diagnosis of obstructive sleep apnoea (OSA). A secondary aim was to revisit the relationship between morphology and OSA severity. Methods: A retrospective analysis was conducted of pre-operative maxillofacial 3D-CT scans of thirty-two patients with a confirmed diagnosis of OSA who received treatment from an ear nose and throat specialist (ENT). Lateral cephalograms were imported into Quick Ceph Studio (Quick Ceph Systems Inc, San Diego, CA, USA) after which linear and angular …

Application Of Critical Realism In Social Work Research: Methodological Considerations, Lynne Soon-Chean Park, Shajimon Peter

Research outputs 2022 to 2026

INTRODUCTION: Critical realism (CR) provides a unique and robust philosophical framework for social work researchers by attending to the role of individual agency and social structure; however, little practical guidance is available regarding how the ontology and epistemology of CR can be applied as a methodological framework for qualitative research. APPROACH: In this article, we explain what CR is in relation to other ontological and epistemological positions and provide some practical suggestions for CR-informed research by drawing on relevant examples from a study that examined the causes of trust among Korean migrants in Aotearoa New Zealand. CONCLUSIONS: We suggest that …

Assessment Of Hole Quality, Thermal Analysis, And Chip Formation During Dry Drilling Process Of Gray Cast Iron Astm A48, Numan Habib, Aamer Sharif, Aqib Hussain, Muhammad Aamir, Khaled Giasin, Danil Yurievich Pimenov

Research outputs 2022 to 2026

The cutting parameters in drilling operations are important for high-quality holes and productivity improvement in any manufacturing industry. This study investigates the effects of spindle speed and feed rate on temperature, surface roughness, hole size, circularity, and chip formation during dry drilling of gray cast iron ASTM A48. The results showed that the temperature increased as spindle speed and feed rate increased. The surface roughness had an inverse relationship with the spindle speed and direct relation with the feed rate. Furthermore, hole size increased with increased spindle speed and decreased as the feed rate increased, while hole circularity decreased with …

Educators’ Perspectives About Teaching And Supporting Students With Learning Difficulties In Reading, Tanya Serry, Pam Snow, Lorraine Hammond, Emina Mclean, Jane Mccormack

Research outputs 2022 to 2026

We explored the perspectives of school-based educators located in Victoria, Australia, regarding their support of students who have reading difficulties. An anonymous survey was completed by 523 participants, including educators, educational leaders and Student Support Services staff. Results revealed multiple areas of concern related to their capacity to work on reading intervention with these students. Although participants reported that students with reading difficulties were present in most classes, confidence to work effectively with these students was mixed. They described feeling poorly prepared by preservice programs and indicated that insufficient time and mentorship prevented them from serving these students optimally. As …

How To Develop A Structural Conception Of Algebra In School Students, Vesife Hatisaru

Research outputs 2022 to 2026

Algebra plays a pivotal role in school students’ mathematics learning. Students, however, have serious difficulties especially with ‘seeing’ the algebraic structures and expressing generality with algebraic symbols. These skills are not gained accidently; developing them in students takes continuous, sustained, and focused effort from both students themselves and teachers. As teachers of mathematics, what kind of classroom experience could we provide our students to prepare them for using algebra successfully? How could we assist them to develop structural conceptions of algebra? In this paper, I describe an approach based on the Mathematical Habits of Mind framework (Cuoco et al., 1996) …

Improving Musculoskeletal Injury Surveillance Methods In Special Operation Forces: A Delphi Consensus Study, Joanne Stannard, Caroline F. Finch, Lauren V. Fortington

Research outputs 2022 to 2026

Musculoskeletal injury mitigation is a priority in military organisations to protect personnel health and sustain a capable workforce. Despite efforts to prevent injury, inconsistencies exist in the evidence used to support these activities. There are many known limitations in the injury surveillance data reported in previous Special Operation Forces (SOF) research. Such studies often lack accurate, reliable, and complete data to inform and evaluate injury prevention activities. This research aimed to achieve expert consensus on injury surveillance methods in SOF to enhance the quality of data that could be used to inform injury prevention in this population. A Delphi study …

Nexus Between Constructs Of Social Cognitive Theory Model And Diabetes Self-Management Among Ghanaian Diabetic Patients: A Mediation Modelling Approach, Yaa Obirikorang, Emmanuel Acheampong, Enoch Odame Anto, Ebenezer Afrifa-Yamoah, Eric Adua, John Taylor, Linda Ahenkorah Fondjo, Sylvester Yao Lokpo, Evans Asamoah Adu, Bernard Adutwum, Enoch Ofori Antwi, Emmanuella Nsenbah Acheampong, Michael Adu Gyamfi, Freeman Aidoo, Eddie-Williams Owiredu, Christian Obirikorang

Research outputs 2022 to 2026

The promotion of Diabetes Self-Management (DSM) practices, education, and support is vital to improving the care and wellbeing of diabetic patients. Identifying factors that affect DSM behaviours may be useful to promote healthy living among these patients. The study assessed the determinants of DSM practices among Type 2 diabetes mellitus (T2DM) patients using a model-based social cognitive theory (SCT). This cross-sectional study comprised 420 (T2DM) patients who visited the Diabetic Clinic of the Komfo Anokye Teaching Hospital (KATH), Kumasi-Ghana. Data was collected using self-structured questionnaires to obtain socio-demographic characteristics, T2DM-related knowledge, DSM practices, SCT constructs; beliefs in treatment effectiveness, level …

Perspectives On Wider Integration Of The Health-Assistive Smart Home, Gordana Dermody, Jenna Mikus, Davina Porock, Dov Sugarman, Naeem K. Janjua, Christopher How, Roschelle Fritz

Research outputs 2022 to 2026

Most older adults desire to be as independent as possible and remain living in their ancestral home as they age. Aging-in-place maximizes the independence of older adults, enhancing their wellbeing and quality of life while decreasing the financial burden of residential care costs. However, due to chronic disease, multimorbidity, and age-related changes, appropriate conditions are required to make aging-in-place possible. Remote monitoring with smart home technologies could provide the infrastructure that enables older adults to remain living independently in their own homes safely. The health-assistive smart home shows great promise, but there are challenges to integrating smart homes on a …

Statistical Analysis Plan For The Stepped-Wedge Clinical Trial Healing Right Way - Enhancing Rehabilitation Services For Aboriginal Australians After Brain Injury, Elizabeth Armstrong, Tapan Rai, Deborah Hersh, Sandra Thompson, Juli Coffin, Natalie Ciccone, Leon Flicker, Dominique Cadilhac, Erin Godecke, Deborah Woods, Colleen Hayward, Graeme J. Hankey, Meaghan Mcallister, Judith Katzenellenbogen

Research outputs 2022 to 2026

Background: Aboriginal Australians are known to suffer high levels of acquired brain injury (stroke and traumatic brain injury) yet experience significant barriers in accessing rehabilitation services. The aim of the Healing Right Way trial is to evaluate a culturally secure intervention for Aboriginal people with newly acquired brain injury to improve their rehabilitation experience and quality of life. Following publication of the trial protocol, this paper outlines the statistical analysis plan prior to locking the database. Methods: The trial involves a stepped wedge design with four steps over 3 years. Participants were 108 adult Aboriginal Australians admitted to one of …

Tox And Detox: Are Teens' Smartphone Use And Non-Use Practices Fully Fungible?, Lelia Green, Debra Dudek, Lynne Cohen, Kjartan Ólafsson, Elisabeth Staksrud, Carmen Louise Jacques, Kelly Jaunzems

Research outputs 2022 to 2026

The public sphere includes a range of credible discourses asserting that a proportion of teenagers (“teens”) has an unhealthy dependence upon continuous connection with media devices, and especially smartphones. A review of media discourse (Jaunzems et al.) in Australia, and a critical review of public discourse in Australia and Belgium (Zaman et al.), reveal both positive and negative commentary around screentime. Despite the “emotionally laden, opposing views” expressed in the media, there appears to be a groundswell of concern around young people’s dependence upon digital devices (Zaman et al. 120). Concerns about ‘addiction’ to and dependency on digital media first …

Temptations, Techniques And Typologies: Insights From A Western Australian Sample Of Young People Who Burgle, Suzanne Rock, Natalie J. Gately, James Mccue, Nathalie St Martin

Research outputs 2022 to 2026

A significant amount of property crime is committed by young people. In this novel qualitative study, 50 young people were interviewed to obtain an insight into their motivations to burgle. Decisions were based on peer pressure, opportunity and perceived need. Bennett and Wright’s typologies of adult burglars were applied to young burglars. Young burglars were more prone than adults in Bennett and Wright’s study to commit opportunistic burglaries, but were deterred by similar target characteristics. The social and psychological factors are strong motivators for youth burglary and should guide the development of intervention and deterrence strategies.

Deep Learning Inspired Feature Engineering For Classifying Tremor Severity, Ahmed Al Taee, Seyedehmarzieh Hosseini, Rami N. Khushaba, Tanveer Zia, Chin-Teng Lin, Adel Al-Jumaily

Research outputs 2022 to 2026

Bio-signals pattern recognition systems can be impacted by several factors with a potential to limit their associated performance and clinical translation. Among these factors, selecting the optimum feature extraction method, that can effectively exploit the interaction between the temporal and spatial information, is the most prominent. Despite the potential of deep learning (DL) models for extracting temporal, spatial, or temporal-spatial information, they are typically restricted by their need for a large amount of training data. The deep wavelet scattering transform (WST) is a relatively recent advancement within the DL literature to replace expensive convolution neural networks models with computationally less …

Effectiveness Of Universal Newborn Hearing Screening: A Systematic Review And Meta-Analysis, Karen Edmond, Shelly Chadha, Cynthia Hunnicutt, Natalie Strobel, Vinaya Manchaiah, Christine Yoshinaga-Itano, Universal Newborn Hearing Screening (Unhs) Review Group

Research outputs 2022 to 2026

Background:

Permanent bilateral hearing loss (PBHL) is a serious condition in newborns, with a prevalence of at least one per 1000 live births. However, there has been no recent systematic review and meta-analysis of the effectiveness of universal newborn hearing screening programs (UNHS).

Methods:

We registered our study protocol on PROSPERO CRD42020175451. Primary outcomes were any identification of PBHL (ie, PBHL diagnosed at any time), age of identification of PBHL, and neurodevelopment. Two reviewers searched standard databases to March 2022 and extracted data. We used fixed and random effects meta-analysis to pool data and graded the certainty of evidence using …

Pre-Service Teachers' Use Of Ict To Collaborate To Complete Assessment Tasks, Eileen V. Slater, Donna Barwood, Zina Cordery

Research outputs 2022 to 2026

This research explored the use of ICT products by n = 123 pre-service teachers to complete collaborative assessments. Students responded to a questionnaire relating to the use, benefits and limitations, and what would better enable the use of ICT for collaborative assessment purposes. The ICT products favoured by students did not support some key elements necessary for online collaboration, through either student use or product functionality. Poor Internet access was a commonly cited limitation with the effect of reducing access to available ICT skills training. Suggestions for changes to course structure and content and further research are made.

Anatomy Of An Internet Hijack And Interception Attack: A Global And Educational Perspective, Ben A. Scott, Michael N. Johnstone, Patryk Szewczyk

Research outputs 2022 to 2026

The Internet’s underlying vulnerable protocol infrastructure is a rich target for cyber crime, cyber espionage and cyber warfare operations. The stability and security of the Internet infrastructure are important to the function of global matters of state, critical infrastructure, global e-commerce and election systems. There are global approaches to tackle Internet security challenges that include governance, law, educational and technical perspectives. This paper reviews a number of approaches to these challenges, the increasingly surgical attacks that target the underlying vulnerable protocol infrastructure of the Internet, and the extant cyber security education curricula; we find the majority of predominant cyber security …

Cerebrospinal Fluid Levels Of Fatty Acid–Binding Protein 3 Are Associated With Likelihood Of Amyloidopathy In Cognitively Healthy Individuals, Kunal Dhiman, Victor L. Villemagne, Christopher Fowler, Pierrick Bourgeat, Qiao-Xin Li, Steven Collins, Christopher C. Rowe, Colin L. Masters, David Ames, Kaj Blennow, Henrik Zetterberg, Ralph N. Martins, Veer Gupta

Research outputs 2022 to 2026

Introduction: Fatty acid–binding protein 3 (FABP3) is a biomarker of neuronal membrane disruption, associated with lipid dyshomeostasis—a notable Alzheimer's disease (AD) pathophysiological change. We assessed the association of cerebrospinal fluid (CSF) FABP3 levels with brain amyloidosis and the likelihood/risk of developing amyloidopathy in cognitively healthy individuals. Methods: FABP3 levels were measured in CSF samples of cognitively healthy participants, > 60 years of age (n = 142), from the Australian Imaging, Biomarkers & Lifestyle Flagship Study of Ageing (AIBL). Results: FABP3 levels were positively associated with baseline brain amyloid beta (Aβ) load as measured by standardized uptake value ratio (SUVR, standardized β …

Exploring Discordant Low Amyloid Beta And High Neocortical Tau Positron Emission Tomography Cases, Natasha Krishnadas, Vincent Doré, Simon M. Laws, Tenielle Porter, Fiona Lamb, Svetlana Bozinovski, Victor L. Villemagne, Christopher C. Rowe

Research outputs 2022 to 2026

Introduction: Neocortical 3R4R (3-repeat/4-repeat) tau aggregates are rarely observed in the absence of amyloid beta (Aβ). 18F-MK6240 binds specifically to the 3R4R form of tau that is characteristic of Alzheimer's disease (AD). We report four cases with negative Aβ, but positive tau positron emission tomography (PET) findings. Methods: All Australian Imaging, Biomarkers and Lifestyle study of aging (AIBL) study participants with Aβ (18F-NAV4694) and tau (18F-MK6240) PET scans were included. Centiloid < 25 defined negative Aβ PET (Aβ–). The presence of neocortical tau was defined quantitatively and visually. Results: Aβ– PET was observed in 276 participants. Four of these participants (one cognitively unimpaired [CU], two mild cognitive impairment [MCI], one AD) had tau tracer retention in a pattern consistent with Braak tau stages V to VI. Fluid biomarkers supported a diagnosis of AD. In silico analysis of APP, PSEN1, PSEN2, and MAPT genes did not identify relevant functional mutations. Discussion: Discordant cases were infrequent (1.4% of all Aβ– participants). In these cases, the Aβ PET ligand may not be detecting the Aβ that is present.

Genes Involved In Platelet Aggregation And Activation Are Downregulated During Acute Anaphylaxis In Humans, Francesca M. Mcgrath, Abbie Francis, Daniel M. Fatovich, Stephen P. J. Macdonald, Glenn Arendts, Andrew J. Woo, Erika Bosio

Research outputs 2022 to 2026

Objective: Mechanisms underlying the anaphylactic reaction in humans are not fully understood. Here, we aimed at improving our understanding of anaphylaxis by investigating gene expression changes. Methods: Microarray data set GSE69063 was analysed, describing emergency department (ED) patients with severe anaphylaxis (n = 12), moderate anaphylaxis (n = 6), sepsis (n = 20) and trauma (n = 11). Samples were taken at ED presentation (T0) and 1 h later (T1). Healthy controls were age and sex matched to ED patient groups. Gene expression changes were determined using limma, and pathway analysis applied. Differentially expressed genes were validated in an independent …