Digital Commons Network^™

Genes Involved In Platelet Aggregation And Activation Are Downregulated During Acute Anaphylaxis In Humans, Francesca M. Mcgrath, Abbie Francis, Daniel M. Fatovich, Stephen P. J. Macdonald, Glenn Arendts, Andrew J. Woo, Erika Bosio

Research outputs 2022 to 2026

Objective: Mechanisms underlying the anaphylactic reaction in humans are not fully understood. Here, we aimed at improving our understanding of anaphylaxis by investigating gene expression changes. Methods: Microarray data set GSE69063 was analysed, describing emergency department (ED) patients with severe anaphylaxis (n = 12), moderate anaphylaxis (n = 6), sepsis (n = 20) and trauma (n = 11). Samples were taken at ED presentation (T0) and 1 h later (T1). Healthy controls were age and sex matched to ED patient groups. Gene expression changes were determined using limma, and pathway analysis applied. Differentially expressed genes were validated in an independent …

Plasma P217+Tau Versus Nav4694 Amyloid And Mk6240 Tau Pet Across The Alzheimer's Continuum, Vincent Doré, James D. Doecke, Ziad S. Saad, Gallen Triana-Baltzer, Randy Slemmon, Natasha Krishnadas, Pierrick Bourgeat, Kun Huang, Samantha Burnham, Christopher Fowler, Stephanie R. Rainey-Smith, Ashley I. Bush, Larry Ward, Jo Robertson, Ralph N. Martins, Colin L. Masters, Victor L. Villemagne, Jurgen Fripp, Hartmuth C. Kolb, Christopher C. Rowe

Research outputs 2022 to 2026

Introduction: We evaluated a new Simoa plasma assay for phosphorylated tau (P-tau) at aa217 enhanced by additional p-tau sites (p217+tau). Methods: Plasma p217+tau levels were compared to 18F-NAV4694 amyloid beta (Aβ) positron emission tomography (PET) and 18F-MK6240 tau PET in 174 cognitively impaired (CI) and 223 cognitively unimpaired (CU) participants. Results: Compared to Aβ− CU, the plasma levels of p217+tau increased 2-fold in Aβ+ CU and 3.5-fold in Aβ+ CI. In Aβ− the p217+tau levels did not differ significantly between CU and CI. P217+tau correlated with Aβ centiloids P =.67 (CI, P =.64; CU, P =.45) and tau SUVRMT P …

Plasma P-Tau181/Aβ1-42 Ratio Predicts Aβ-Pet Status And Correlates With Csf-P-Tau181/Aβ1-42 And Future Cognitive Decline, Christopher J. Fowler, Erik Stoops, Stephanie R. Rainey-Smith, Eugeen Vanmechelen, Jeroen Vanbrabant, Nele Dewit, Kimberley Mauroo, Paul Maruff, Christopher C. Rowe, Jurgen Fripp, Qiao-Xin Li, Pierrick Bourgeat, Steven J. Collins, Ralph N. Martins, Colin L. Masters, James D. Doecke

Research outputs 2022 to 2026

Background: In Alzheimer's disease (AD), plasma amyloid beta (Aβ)1-42 and phosphorylated tau (p-tau) predict high amyloid status from Aβ positron emission tomography (PET); however, the extent to which combination of these plasma assays can predict remains unknown. Methods: Prototype Simoa assays were used to measure plasma samples from participants who were either cognitively normal (CN) or had mild cognitive impairment (MCI)/AD in the Australian Imaging, Biomarkers and Lifestyle (AIBL) study. Results: The p-tau181/Aβ1-42 ratio showed the best prediction of Aβ-PET across all participants (area under the curve [AUC] = 0.905, 95% confidence interval [CI]: 0.86–0.95) and in CN (AUC = …

A Review On Security Issues And Solutions Of The Internet Of Drones, Wencheng Yang, Song Wang, Xuefei Yin, Xu Wang, Jiankun Hu

Research outputs 2022 to 2026

The Internet of Drones (IoD) has attracted increasing attention in recent years because of its portability and automation, and is being deployed in a wide range of fields (e.g., military, rescue and entertainment). Nevertheless, as a result of the inherently open nature of radio transmission paths in the IoD, data collected, generated or handled by drones is plagued by many security concerns. Since security and privacy are among the foremost challenges for the IoD, in this paper we conduct a comprehensive review on security issues and solutions for IoD security, discussing IoD-related security requirements and identifying the latest advancement in …

Exploring Issues Of Resilience And Technology Use For Older People - A Scoping Review Protocol, Timothy J. Smith, Khui Hung Lee, Kan Yu, Leisa Armstrong, David M. Cook

Research outputs 2022 to 2026

The aim of this scoping review is to understand the extent of issues of resilience implied by the interactions of older people with financial, social, and health related technologies. Older people aged 60+, technology use or non-use, and issues of resilience studied over the last four years (2019-2022) demarcate the scope of this review. Key exclusion criteria are older adults living in long-term care facilities, nursing homes, care homes and hospital in-patients. It also excludes studies on the perspectives of older peoples’ clinicians. The review will be carried out according to the Joanna Briggs Institute (JBI) scoping review methodology. The …

Children’S Digital Citizenship Project: Your Perspectives: A Report For Children, Harrison See, Kylie Stevenson, Emma Jayakumar, Phoebe Zeng

Research outputs 2022 to 2026

This report talks about a teamwork project between the LEGO Group, the Australian Research Council (ARC) Centre of Excellence for the Digital Child (Digital Child) and Edith Cowan University (ECU).

In 2022, the LEGO Group, ECU and Digital Child researchers teamed up to ask children and adults in India, Korea and Australia about digital citizenship. We collected all this information together and compared our results, and then made some suggestions about how we can all do things better to help kids be safer, smarter, and happier online.

Children’S Perspectives Of Digital Citizenship In India, Korea And Australia: Report Of Findings From Children’S Digital Citizenship And Safety Roundtables, Kylie Stevenson, Emma Jayakumar, Harrison See, Yeonghwi Ryu, Shruti Das

Research outputs 2022 to 2026

This report presents data and findings from Phase Two of the research project Digital Safety and Citizenship Roundtables. In this phase, which focuses on children’s perspectives of digital safety and digital citizenship, three child-focused, play-based roundtables were held in Seoul (Korea), Delhi (India) and Perth (Australia) respectively in the months of June and July 2022, with 48 children in total contributing their perspectives. Qualitative data was collected from these child participants through 90-minute play-based roundtables featuring three sections: a short introductory drawing activity using prompt cards; a discussion regarding the children’s understanding of digital citizenship; and a LEGO play activity …

Contexts For Children’S Digital Citizenship In India, Korea And Australia: A Literature Review, Kylie Stevenson, Emma Jayakumar, Viet Tho Le, Yeonghwi Ryu, Harrison See

Research outputs 2022 to 2026

Children’s digital citizenship today: In an increasingly digitised and technically mediated world, an individual’s digital citizenship, or “ability to use digital technology and media in safe, responsible and ethical ways” (DQ Institute, 2019) has never been more relevant, particularly when it concerns our youngest digital citizens. Navigating online spaces safely and confidently are skills fundamental to a modern individual’s social and emotional development, education, work and play. A digital citizen’s abilities, however, are greatly impacted by notions of access; not just physical access, but also access mediated culturally and socio-economically. Less is known about very young children’s experiences of digital …

Cyber Security Curriculum In Western Australian Primary And Secondary Schools: Interim Report: Curriculum Mapping, Nicola Johnson, Ahmed Ibrahim, Leslie Sikos, Cheryl Glowrey

Research outputs 2022 to 2026

Cyber-crime poses a significant threat to Australians—think of, for example, how scams take advantage of vulnerable people and systems. There is a need to educate people from an early age to protect them from cyberthreats.

Consistent with the increasing prevalence of cyberthreats to individuals and organisations in Australia, the national Australian curriculum has been updated (version 9.0) to include specific content for cyber security for primary and secondary students up to Year 10. Endorsed by Education Ministers in April 2022, the Western Australian School Curriculum and Standards Authority (SCSA) completed a detailed audit of the endorsed Australian Curriculum version 9.0 …

Fundamental Data Analysis Tools And Concepts For Bioacoustical Research, Chandra Salgado Kent, Tiago A. Marques, Danielle Harris

Research outputs 2022 to 2026

Bioacoustics is a growing field of research in which sound is measured to gain knowledge about species’ natural history and their environments. For example, bioacousticians have been able to create phylogenies, identify populations, and estimate abundance using sound. Moreover, today, many animals are exposed to human-generated noise, which can impact animals’ behavior, ability to communicate, physiology, hearing, and, in some instances, survival. Bioacoustics, thus, is commonly used to assess and predict the impacts of anthropogenic noise on animals and their populations. The use of bioacoustics to address such research questions, however, is only effective provided the quantitative and statistical analysis …

Faces Of Pain In Dementia: Learnings From A Real-World Study Using A Technology-Enabled Pain Assessment Tool, Mustafa Atee, Kreshnik Hoti, Paola Chivers, Jeffery D. Hughes

Research outputs 2022 to 2026

Pain is common in people living with dementia (PLWD), including those with limited verbal skills. Facial expressions are key behavioral indicators of the pain experience in this group. However, there is a lack of real-world studies to report the prevalence and associations of pain-relevant facial micro-expressions in PLWD. In this observational retrospective study, pain-related facial features were studied in a sample of 3,144 PLWD [mean age 83.3 years (SD = 9.0); 59.0% female] using the Face domain of PainChek®, a point-of-care medical device application. Pain assessments were completed by 389 users from two national dementia-specific care programs and 34 Australian …

Helping Students From Refugee Backgrounds Succeed In Higher Education Through Support Systems, Arinola Adebayo

Theses and Dissertations

Like every student enrolled in a higher education institution, students from refugee backgrounds are not only concerned about how to get into college, but how to connect with the support systems available to them on campus. The purpose of this research was to examine the social support systems available to college students from refugee backgrounds while on campus, the resources these students engaged in to keep them connected to college, and how they tapped into available resources to be successful in achieving their higher educational career and goals. Using qualitative methods, this research used an intrinsic-embedded, single-case design case study. …

The Impact Of Stress Dependent Permeability Alteration On Gas Based Eor In The Bakken Formation, Ailin Assady

Theses and Dissertations

Effective stress exerted on porous rocks can change and alter reservoir permeability accordingly during reservoir development. The permeability evolution under different reservoir statues will impact oil production and EOR design in the Bakken shale porous media. An accurate permeability model can improve capturing the fluid transport mechanism and create a reliable long-term dynamic fluid forecast via reservoir simulation. This research is focused on studying permeability alteration behavior under different pressure circumstances. The reservoir gradually loses its original pore pressure during production, increasing reservoir net effective stress. Therefore, a reduction in reservoir properties such as permeability or porosity can occur in …

An Introduction To Numerical Relativity And Simulations Of Binary Neutron Stars, Hayden Dale Drown

Theses and Dissertations

The theory of general relativity is currently the best description of gravity. However, the equations in general relativity are highly nonlinear and only the simplest of cases can hope to be solved analytically. As a result, the field of numerical relativity was created to solve some of these issues and to model more complicated dynamical situations. This thesis sets out to give the reader a basic understanding of general relativity, numerical relativity, as well as an understanding of some of the programs that are used in numerical relativity research such as Lorene and the Einstein Toolkit and concludes with a …

The Effect Of Mineral Composition On Elastic Properties Of The Bakken Formation In The Williston Basin, North Dakota, John Albert Harju

Theses and Dissertations

Hydrocarbon production from tight oil and/or shale plays requires drilling horizontal wells with very long laterals and hydraulic fracturing operations to stimulate the reservoirs which have generally very low porosity and permeability. A great amount of experience has been accumulated over the past two decades in the North America from production of these types of reservoirs. The Bakken formation in North Dakota, is one of the largest tight oil producers in the U.S.A. and currently ranks as the second largest producer of oil in the nation. The Bakken formation is divided into the upper and lower shale members, which are …

Development Of A Food Composition Database For Assessing Nitrate And Nitrite Intake From Animal-Based Foods, Liezhou Zhong, Alex H. Liu, Lauren C. Blekkenhorst, Nicola P. Bondonno, Marc Sim, Richard J. Woodman, Kevin D. Croft, Joshua R. Lewis, Jonathan M. Hodgson, Catherine P. Bondonno

Research outputs 2022 to 2026

Scope:

Nitrate and nitrite are approved food additives in some animal-based food products. However, nitrate and nitrite in foods are strictly regulated due to health concerns over methaemoglobinaemia and the potential formation of carcinogenic nitrosamines. In contrast, plants (like leafy vegetables) naturally accumulate nitrate ions; a growing body of research reveals beneficial metabolic effects of nitrate via its endogenous conversion to nitric oxide. To refine the association of dietary nitrate and nitrite intake with health outcomes, reliable measures of nitrate and nitrite intake from dietary food records are required. While a vegetable nitrate content database has been developed, there is …

Optimal Sizing And Energy Scheduling Of Grid-Supplemented Solar Pv Systems With Battery Storage: Sensitivity Of Reliability And Financial Constraints, Aakash Hassan, Yasir M. Al-Abdeli, Martin Masek, Octavian Bass

Research outputs 2022 to 2026

Establishing reliable, clean, and inexpensive solar PV systems is a complex interplay between the level of reliability (LPSP), financial constraints, and CO2 emissions. This paper investigates the impact of these factors on stand-alone (SA) and grid-supplemented (GS) solar PV systems over multiple seasons. The research uses established hardware models, detailed power management strategies as well as realistic Australian grid tariffs and Genetic Algorithms to find the minimum Cost of Energy (COE) subject to LPSP and financial constraints. The developed power management strategies are also tested experimentally on a real solar PV system. The results indicate that the grid-supplemented system yields …

The Role Of Tribal Funding In American Indian Postsecondary Success: Inquiry Into The Problem Of Practice, Delana Lynn Mclean

Theses and Dissertations

The rising costs of college attendance and the diminishing availability of viable funding sources cause students to incur debt in order to pursue postsecondary education. This dissertation in practice examines how one tribal education funding program contributed to the successful transition between high school and college for the enrolled members of the Mandan Hidatsa Arikara (MHA) Nation in North Dakota. I used a quantitative method to examine which pre-college and in-college characteristics were associated with the success outcomes, such as retention and academic achievement (as measured by the first-year college GPA) after the first year of transition to a postsecondary …

Design Of Novel High-Performance Materials For Sliding Applications, Caleb Michael Matzke

Theses and Dissertations

Break down of a material due to mechanical usage, otherwise known as wear, is a common issue that affects almost every industry as well as many commonly used goods. Components, such as bearings, can have major damage over time, especially if they are not protected by a lubricant. This thesis investigates the friction and wear behavior of high-performance materials lubricated by fuel-based lubricants. This work is divided into two parts; The first focuses on polymer matrix composites, and the second focuses on advanced ceramics. Polymers are of interest due to the ease of production and the polymer of choice for …

Towards A Digital Twin For Characterising Natural Source Zone Depletion: A Feasibility Study Based On The Bemidji Site, Kaveh Sookhak Lari, Greg B. Davis, John L. Rayner

Research outputs 2022 to 2026

Natural source zone depletion (NSZD) of light non-aqueous phase liquids (LNAPLs) may be a valid long-term management option at petroleum impacted sites. However, its future long-term reliability needs to be established. NSZD includes partitioning, biotic and abiotic degradation of LNAPL components plus multiphase fluid dynamics in the subsurface. Over time, LNAPL components are depleted and those partitioning to various phases change, as do those available for biodegradation. To accommodate these processes and predict trends and NSZD over decades to centuries, for the first time, we incorporated a multi-phase multi-component multi-microbe non-isothermal approach to representatively simulate NSZD at field scale. To …

Evaluation Of Virtual Screening Strategies For The Identification Of Γ-Secretase Inhibitors And Modulators, Alicia Ioppolo, Melissa Eccles, David Groth, Giuseppe Verdile, Mark Agostino

Research outputs 2022 to 2026

γ-Secretase is an intramembrane aspartyl protease that is important in regulating normal cell physiology via cleavage of over 100 transmembrane proteins, including Amyloid Precursor Protein (APP) and Notch family receptors. However, aberrant proteolysis of substrates has implications in the progression of disease pathologies, including Alzheimer’s disease (AD), cancers, and skin disorders. While several γ-secretase inhibitors have been identified, there has been toxicity observed in clinical trials associated with non-selective enzyme inhibition. To address this, γ-secretase modulators have been identified and pursued as more selective agents. Recent structural evidence has provided an insight into how γ-secretase inhibitors and modulators are recognized …

Digitalization In Food Supply Chains: A Bibliometric Review And Key-Route Main Path Analysis, Abderahman Rejeb, Karim Rejeb, Alireza Abdollahi, Suhaiza Zailani, Mohammad Iranmanesh, Morteza Ghobakhloo

Research outputs 2022 to 2026

Technological advances such as blockchain, artificial intelligence, big data, social media, and geographic information systems represent a building block of the digital transformation that supports the resilience of the food supply chain (FSC) and increases its efficiency. This paper reviews the literature surrounding digitalization in FSCs. A bibliometric and key-route main path analysis was carried out to objectively and analytically uncover the knowledge development in digitalization within the context of sustainable FSCs. The research began with the selection of 2140 articles published over nearly five decades. Then, the articles were examined according to several bibliometric metrics such as year of …

Effective Differentiation Strategies For Engaging English Language Learners In The General Education Classroom: An Implementation Study, Renee Ullom

Theses and Dissertations

Because of the growing population of English Language Learners (ELL) (U.S. Department of Education, 2020) and lack of time, training, and resources for teachers, there is an intense need for identification of effective differentiation strategies for teachers to implement in the general education classroom, which allows ELL students to engage in grade-level curriculum while acquiring English. This mixed methods research study examines who ELL students are, barriers to success faced by ELL students, barriers to teachers when planning and delivering curriculum in the general education classroom. The investigation additionally explores the identification and implementation of effective differentiation strategies for ELL …

Retired Indigenous And Non-Indigenous College Student Athletes' Mental Health Relating To Athletic Identity, Cultural Identity, And Career Transition, Victoria Williams

Theses and Dissertations

To date, empirical studies have investigated the transition or retirement phase, following the conclusion of a student-athletes’ four-year career as a comparison between student-athletes and non-athletes. Specifically, when investigating these constructs, researchers have failed to thoroughly investigate the role cultural identity may play in mitigating psychological symptoms during the transition phase. As such, this study will seek to investigate both Indigenous and non-Indigenous retired college student- athletes, during the transition phase, in terms of the degree to which they identified with their athletic identity, cultural identity and career transition. It is expected those retired Indigenous and non-Indigenous student- athletes who …

The Nursing Care Of People With Class Iii Obesity In An Acute Care Setting: A Scoping Review, Bev Ewens, Vivien Kemp, Mandy (Amanda) Towell-Barnard, Lisa Whitehead

Research outputs 2022 to 2026

Background

Patients with Class III obesity pose unique challenges to health care staff and organisations. Care requirements of this population are unique and require specialised equipment and knowledge to meet these needs, maintain the quality of care, as well as the safety of patients and staff.

Aim

To synthesise the evidence on the nursing care of Class III obese patients in acute care settings.

Methods

A scoping review informed by JBI. CINAHL Plus, Medline, Scopus, Proquest Central, Web of Science and Embase were searched for primary research articles about the nursing management of people classified as Class III obese in …

Reference-Free Differential Histogram-Correlative Detection Of Steganography: Performance Analysis, Natiq M. Abdali, Zahir M. Hussain

Research outputs 2022 to 2026

Recent research has demonstrated the effectiveness of utilizing neural networks for detect tampering in images. However, because accessing a database is complex, which is needed in the classification process to detect tampering, reference-free steganalysis attracted attention. In recent work, an approach for least significant bit (LSB) steganalysis has been presented based on analyzing the derivatives of the histogram correlation. In this paper, we further examine this strategy for other steganographic methods. Detecting image tampering in the spatial domain, such as image steganography. It is found that the above approach could be applied successfully to other kinds of steganography with different …

Changes In Body Composition In Patients With Malignant Pleural Mesothelioma And The Relationship With Activity Levels And Dietary Intake, Emily Jeffery, Y. C. Gary Lee, Robert U. Newton, Philippa Lyons-Wall, Joanne Mcveigh, Deirdre B. Fitzgerald, Leon Straker, Carolyn J. Peddle-Mcintyre

Research outputs 2022 to 2026

Background:

Skeletal muscle loss is common in advanced cancer and is associated with negative outcomes. In malignant pleural mesothelioma (MPM), no study has reported body composition changes or factors associated with these changes. This study aimed to describe changes in body composition over time and its relationship with activity levels, dietary intake and survival.

Methods:

The study was a secondary analysis of data collected from a longitudinal observational study of patients with MPM. Participants completed 3-month assessments for up to 18 months. Participants with two dual-energy x-ray absorptiometry (DXA) scans were included. Changes in appendicular skeletal muscle mass (ASM) and …

Feasibility And Therapeutic Efficacy Of A Two-Week Low-Level Laser Acupuncture Therapy For Shoulder And Neck Pain In Office Workers: Protocol For A Pilot, Single-Blind, Doublearmed, Randomised Controlled Trial, Carol Chunfeng Wang, Lisa Whitehead, Travis Cruickshank, Johnny Lo, Jianhong Xia, Jun Wen

Research outputs 2022 to 2026

Background:

Shoulder and neck pain (SNP) is common in office workers and represents a serious public health problem given its detrimental impact on quality of life, physical functioning, personal finances, employers, and the health care system. Management with painkillers has adverse implications such as tolerance, addiction, and opioid abuse. Safe, sustainable, cost-effective, and evidence-based solutions are urgently needed. The non-invasive, painless, noninfectious, and safe modality of low-level laser acupuncture (LLLA) has shown promise for SNP management.

Objective:

The overarching aim of this study is to provide evidence of the feasibility and therapeutic efficacy of LLLA for office workers with SNP. …

Investigating Secondary Mathematics Teachers’ Analogies To Function, Vesife Hatisaru

Research outputs 2022 to 2026

This study investigates the analogies used by a sample of secondary mathematics teachers when they described the concept of function. The study is concerned with understanding what analogies were used by the participant teachers and conceptions of functions positioned in those analogies. Using examples from a set of responses to five open-ended questionnaire items, the article presents the main analogies found in the descriptions of the participant teachers and examines ways in which these are structurally mapped to function by applying Gentner’s structure-mapping theory of analogy. Among those discussed are the child–mother linkage and machine/factory analogies. Of interest is the …

Automatic And Fast Classification Of Barley Grains From Images: A Deep Learning Approach, Syed Afaq Ali Shah, Hao Luo, Putu Dita Pickupana, Alexander Ekeze, Ferdous Sohel, Hamid Laga, Chengdao Li, Blakely Paynter, Penghao Wang

Research outputs 2022 to 2026

Australia has a reputation for producing a reliable supply of high-quality barley in a contaminant-free climate. As a result, Australian barley is highly sought after by malting, brewing, distilling, and feed industries worldwide. Barley is traded as a variety-specific commodity on the international market for food, brewing and distilling end-use, as the intrinsic quality of the variety determines its market value. Manual identification of barley varieties by the naked eye is challenging and time-consuming for all stakeholders, including growers, grain handlers and traders. Current industrial methods for identifying barley varieties include molecular protein weights or DNA based technology, which are …