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Articles 31801 - 31830 of 2913382
Full-Text Articles in Entire DC Network
Parental Incarceration: The Lived Experiences Of Those Left Behind, Shatoya L. Young
Parental Incarceration: The Lived Experiences Of Those Left Behind, Shatoya L. Young
Doctoral Dissertations and Projects
Incarceration in the United States is being touted as an obscure public health crisis. Approximately 47% of male incarcerated individuals and 58% of female incarcerated individuals are parents to minors. The number of children who have experienced parental incarceration at any point in their lives is believed to be more than 5 million. Incarceration negatively impacts the lives of children, especially when children lack an understanding of their parents' incarceration. There are risk factors that increase the possibility of adverse outcomes for children of incarcerated parents, and protective factors that mitigate the risk of poor outcomes. Many of the stories …
The Lived Experiences Of South Carolina Public School Teachers On The Effects Of Servant Leadership On Teacher Retention: A Transcendental Phenomenological Study, Victor P. Rockhill
The Lived Experiences Of South Carolina Public School Teachers On The Effects Of Servant Leadership On Teacher Retention: A Transcendental Phenomenological Study, Victor P. Rockhill
Doctoral Dissertations and Projects
The purpose of this transcendental phenomenological study was to describe the lived experiences of secondary teachers in South Carolina with servant leader traits and their effects on teacher retention. The conceptual framework for this study was Robert Greenleaf’s servant leadership, as phrased by Van Dierendonck’s five traits of servant leadership, which have a positive effect on teachers’ retention. The central research question was: How do public school teachers in South Carolina describe the effects of servant leadership on teacher retention? This study used Moustakas’ Modified van Kaam method to arrive at the essence of the phenomenon by analyzing the data …
Exploring The Lived Experiences Of Resilient Special Education Teachers In Jamaica, Carlene Lawrence
Exploring The Lived Experiences Of Resilient Special Education Teachers In Jamaica, Carlene Lawrence
Doctoral Dissertations and Projects
The purpose of this transcendental phenomenological study was to describe the lived experiences of resilient special education teachers in Jamaica. The theoretical framework for this study was based on Richard Lazarus and Susan Folkman's cognitive appraisal theory, also known as the cognitive appraisal theory of stress and coping, as it is related to how special education teachers appraised and coped with stress. What did appraisal and coping look like in the lived experiences of resilient special education teachers from Jamaica? Given the nature of a transcendental phenomenological approach, which focuses on describing a phenomenon, this approach was suitable for this …
Recognition And Rewards In Healthcare: A Qualitative Exploration Of Employee Experiences Within A Single Health System, Karen B. Brodbeck
Recognition And Rewards In Healthcare: A Qualitative Exploration Of Employee Experiences Within A Single Health System, Karen B. Brodbeck
Doctoral Dissertations and Projects
This qualitative study, grounded in a constructivist research paradigm, explored how enhancing recognition and reward systems within a healthcare organization improved employee morale, retention, and overall organizational success. Guided by a flexible research design, the study sought to understand the lived experiences of healthcare professionals and how they perceived recognition within their organizational environments. Data were collected through in-depth interviews with 25 to 30 participants, allowing for rich, contextualized insights into how recognition practices influenced motivation, engagement, and commitment. By examining participants’ subjective interpretations and shared meanings, the research illuminated how recognition and reward systems were experienced in practice and …
A Phenomenological Study Of The Lived Experiences Of Members Of Alcoholics Anonymous Which Changes Behavior From Addiction To Recovery, Marie Buchanan Wiles
A Phenomenological Study Of The Lived Experiences Of Members Of Alcoholics Anonymous Which Changes Behavior From Addiction To Recovery, Marie Buchanan Wiles
Doctoral Dissertations and Projects
The purpose of this transcendental phenomenological study is to understand the experiences of AA members in rural southern Virginia, leading to behavior changes from addiction to recovery. Exploring these experiences will provide an understanding of how this organization provides recovery capital, reduces rural barriers to addiction treatment, and facilitates a spiritual awakening that supports behavior change. The spiritual awakening is achieved by following the 12-step principles of AA, which results in behavioral changes leading to improved sobriety outcomes. Changes in behavior have been explained by the Social Cognitive Theory, which posits that behavior results from a reciprocal interaction between the …
A Phenomenological Study Of The Perspectives Of Transition Planning For High School Special Educators, Keva A. Adams
A Phenomenological Study Of The Perspectives Of Transition Planning For High School Special Educators, Keva A. Adams
Doctoral Dissertations and Projects
The purpose of this hermeneutic phenomenological study was to understand the experiences of integrating transition planning for special educators at secondary schools in Triton County, Michigan. The theory guiding this study is Ajzen’s theory of planned behavior, as the principle theorizes that an individual’s behavior is determined by their intentions and perceived behavior of control. The central research question of this study is: What are special educators’ lived experiences integrating special education transition planning at secondary schools in Triton County, Michigan? The design of this study employed hermeneutic phenomenological design with various units of analysis. The data was collected through …
A Quantitative Analysis Of Ptsd Symptom Severity, Alcohol Use, And Resilience In American Military Veterans Using Standardised Assessment Instruments, Oladimeji Owolabi
A Quantitative Analysis Of Ptsd Symptom Severity, Alcohol Use, And Resilience In American Military Veterans Using Standardised Assessment Instruments, Oladimeji Owolabi
Doctoral Dissertations and Projects
Post-Traumatic Stress Disorder (PTSD) continues to be a significant mental health concern among U.S. military veterans. This quantitative study examines the interrelationships among PTSD symptom severity, alcohol use, and psychological resilience using three standardised instruments: the PTSD Checklist for DSM-5 (PCL-5), the Alcohol Use Disorders Identification Test (AUDIT), and the Connor-Davidson Resilience Scale (CD-RISC). A cross-sectional correlational design was implemented with a convenience sample of 150 American military veterans, recruited through online platforms and veteran-focused organisations from all branches. Participants completed an anonymous online survey that assessed trauma-related symptoms, alcohol consumption behaviours, and resilience levels. Statistical analysis included descriptive statistics, …
The Perceived Influence Of Co-Curricular Support Systems On The Educational Leadership And Development Of High-School-Aged Children In Single-Parent Homes In South Florida: A Transcendental Phenomenological Study, Jonathan A. Biles
Doctoral Dissertations and Projects
The purpose of this transcendental phenomenological study was to describe the perceptions of co-curricular support systems regarding the educational leadership and development of high-school-aged children in single-parent homes in South Florida. Focusing on the Tri-County area of South Florida, the theory guiding this research is Erik Erikson’s eight stages of psychosocial development, which pertain to the adolescent stage of development. The central research question was: What is the perception of co-curricular activities' influence on the academic achievement of adolescent-aged students raised in single-parent homes? Using multiple data collection methods: questionnaires, personal interviews, and focus groups, the data gathered was used …
Establishing The St. Paul Ame Church’S Community Youth Chaplain Ministry To Equip African American Youth To Manage Their Mental, Emotional, And Spiritual Health, Michelle A. Creer
Establishing The St. Paul Ame Church’S Community Youth Chaplain Ministry To Equip African American Youth To Manage Their Mental, Emotional, And Spiritual Health, Michelle A. Creer
Doctoral Dissertations and Projects
African American youth face a myriad of challenges that negatively impact their well-being. As such, this study explores the role of community youth chaplaincy interventions in helping African American youth manage their mental, emotional, and spiritual health. The study focused on training the trainers who will guide and support the young people. The training and self-application/intervention centered on building resilience, identity formation, addressing racial trauma, and nurturing spiritual growth through understanding that God created participants in His image and their identity is in Christ. Nine adult participants who are engaged in churches and activities within the African American community, contributed …
Career And Technical Education Faculty Members' Attitudes Toward Assessment: A Case Study, Cecelia R. Brewer
Career And Technical Education Faculty Members' Attitudes Toward Assessment: A Case Study, Cecelia R. Brewer
Doctoral Dissertations and Projects
The purpose of this case study was to understand career and technical education (CTE) faculty members’ attitudes toward assessment at a community college in Kansas. This study explored how faculty members perceived and engaged with outcomes assessment, including their beliefs about its effectiveness, their level of influence in assessment-related decisions, and their sense of being valued within a culture of assessment. The research questions were: 1) What are faculty members’ attitudes toward various assessment methods in career and technical education, including the assessment of both knowledge and skills?, 2) How much do faculty members believe assessment contributes to improving teaching …
Intergenerational Apologetics: A Strategy For Careful Confidence, Thomas C. Farley
Intergenerational Apologetics: A Strategy For Careful Confidence, Thomas C. Farley
Doctoral Dissertations and Projects
There is a subtle confusion between the objectives of evangelism and apologetics, leaving Open Door Baptist Church (ODBC) seniors unknowingly ill-equipped and intimidated to defend their Christian values. The purpose of this Doctor of Ministry research was to address that intimidation by training seniors in a dedicated faith-values curriculum to become confident apologetic communicators. The intervention leveraged the process of intergenerational values-sharing while training stakeholders to develop their own faith narratives by seamlessly integrating biblical values with relevant apologetic particulars into personal stories to be shared with their grandchildren. In this environment, participants could develop a personal faith narrative that …
The Shared Experiences Of Learning Forgiveness Of Oneself Using The Reach Forgiveness Model For Those With Chronic Illnesses And Disabilities, Diane Delezene Browers
The Shared Experiences Of Learning Forgiveness Of Oneself Using The Reach Forgiveness Model For Those With Chronic Illnesses And Disabilities, Diane Delezene Browers
Doctoral Dissertations and Projects
The purpose of this qualitative phenomenological research study was to understand the shared lived experiences of disabled persons after using self-forgiveness coping skills. The theory guiding this study is Lazarus and Folkman’s stress and coping theory, which explores the ability of a person to manage stressors when the mind is overwhelmed and the ability to cope with stress falters. Furthermore, the stress and coping model of forgiveness, which was developed lessen stress by using forgiveness as a coping strategy, and critical disability theory are foundational to this study with specific relation to chronic illness, mental health, and ableism. The principal …
The Lived Experiences Of Community College Faculty Working With Students With Cross-Categorical Disabilities: A Phenomenological Study, Michelle Rosalie Amenta
The Lived Experiences Of Community College Faculty Working With Students With Cross-Categorical Disabilities: A Phenomenological Study, Michelle Rosalie Amenta
Doctoral Dissertations and Projects
The purpose of this transcendental phenomenological study was to describe the preparedness towards disability for faculty members at community colleges. The theory guiding this study was Oliver’s social model of disability, as the theory explained the relationship between environmental, institutional, and attitudinal barriers and disabilities. The central research question was: What are the lived experiences of community college faculty who instruct students that self-disclose their cross-categorical disabilities? The research sample included thirteen faculty members from community colleges in varied disciplines across the United States. Data collection consisted of individual interviews and focus groups, with analysis using Moustakas’ modified Stevick-Colaizzi-Keen Method …
The Media's Influence On The Public's Perception Of Police Use Of Force, Kristopher D. Lauro
The Media's Influence On The Public's Perception Of Police Use Of Force, Kristopher D. Lauro
Doctoral Dissertations and Projects
Police use of force has long been a concern within law enforcement, but in recent decades, it has faced increasing scrutiny from the general public and across all sectors of society, sparking widespread debate on the practice. The rise of body-worn cameras (BWCs) and the prevalence of cell phone recordings of police incidents have amplified attention on the issue. Media representations of police use of force are influential in bringing together or shaping public opinion and often encapsulate ideological biases; the pervasive publicity associated with such incidents provides a unique opportunity for detailed examination of the underlying relationship between media …
A Father To The Fatherless: A Trauma-Informed Care Ministry For Fatherless Fathers, Delmus L. Gillis
A Father To The Fatherless: A Trauma-Informed Care Ministry For Fatherless Fathers, Delmus L. Gillis
Doctoral Dissertations and Projects
This DMIN action research project proposed that the Bethlehem Baptist Church (BBC) did not develop ministries that specifically addressed the persistent unbiblical endemic of fatherlessness within its congregation. The initial tragedy of fatherlessness can be transformed into the beautiful design of godly families when proper attention is given to the root cause of damaged relationships and effective means of correcting abnormalities are properly instituted in the church. Therefore, the researcher created the Trauma-Informed Care Ministry for Fatherless Fathers to guide fathers who experienced fatherlessness into a biblical model of fatherhood. When the church remains silent on important matters of faith, …
A Hermeneutic Phenomenological Study Exploring Inclusion Of Latinos In Higher Education In Bilingual Programs, Carmem Charette
A Hermeneutic Phenomenological Study Exploring Inclusion Of Latinos In Higher Education In Bilingual Programs, Carmem Charette
Doctoral Dissertations and Projects
The purpose of this hermeneutic phenomenological study was to understand the lived experiences of promoting the inclusion of Latino/a students through bilingual programs at higher education institutions in the United States. To include Latinos in higher education administrators redesigned courses originally taught in English into Spanish and Portuguese at several colleges and universities nationwide. This qualitative research was designed as a hermeneutic phenomenological study, and three data collection methods were used: journal prompts, individual interviews, and focus group interviews. Data were collected from educational leaders, including administrators, deans, faculty coordinators, advisers, and professors, who shared their perspectives and experiences as …
Circumstances Surrounding Officer Involved Fatal Shootings, James Corrin
Circumstances Surrounding Officer Involved Fatal Shootings, James Corrin
Doctoral Dissertations and Projects
Over the past several years, there has been concern from mainstream media outlets, politicians, citizens, and community leaders that police officers in the United States engage in unjustified use of deadly force events within communities. This has led to violent protests across the country. Police reform and the de-funding of the police have been a crucial topic for debate and discussion. An argument has been made by some individuals that law enforcement officers involved in the fatal shootings of unarmed Black male citizens are racially motivated. The purpose of the following research is to identify if these arguments are valid. …
Sexual Scripts In Conflict: Does Religiosity Moderate The Relationship Between Pornography Use And Permissive Sexuality?, Alex D. Castaneda
Sexual Scripts In Conflict: Does Religiosity Moderate The Relationship Between Pornography Use And Permissive Sexuality?, Alex D. Castaneda
Doctoral Dissertations and Projects
The sexual script acquisition, activation, and application model (3AM) posits that viewing pornography leads to the internalization of the scripts implicitly and explicitly depicted. Recent research indicates that pornography viewing is associated with more permissive sexuality. Religious individuals, especially conservative Christians, report greater distress from their pornography use, and research has investigated the role of religiosity in pornography-related outcomes. Religiosity has been shown to protect against pornography exposure and buffer against the internalization of the pornographic script. Sexual script theory posits that individuals with existing scripts that are more deeply held will be less susceptible to new, contradictory scripts. This …
Machine Learning-Based Determination Of Sex-Related Bladder Cancer Biomarkers, Joseph Pizzi
Machine Learning-Based Determination Of Sex-Related Bladder Cancer Biomarkers, Joseph Pizzi
Theses
Bladder cancer exhibits sex-specific behavior, occurring more frequently in males but progressing to advanced stages more commonly in females. The activation of sex hormone receptors may explain these differences, but the exact genetic drivers remain poorly understood. Furthermore, current bladder cancer biomarkers have inconsistent sensitivities and specificities in practice, making early diagnosis a challenge. This study approaches bladder cancer biomarker discovery through machine learning techniques on gender and disease-stratified RNA-seq data. Training sets limited to differentially expressed genes were subjected to four different feature selection methods: differential gene expression analysis adjusted p-value, recursive feature elimination with support vector machine, logistic …
Simulations Of A High Ozone Episode And Heatwave Day Using A Coupled Multi-Layer Urban Canopy And Chemistry Model, H. Gamarro, W. M. Angevine, B. C. Mcdonald, R. Bornstein, P. Ramamurthy, F. Moshary, L. M. Judd, J. E. González-Cruz
Simulations Of A High Ozone Episode And Heatwave Day Using A Coupled Multi-Layer Urban Canopy And Chemistry Model, H. Gamarro, W. M. Angevine, B. C. Mcdonald, R. Bornstein, P. Ramamurthy, F. Moshary, L. M. Judd, J. E. González-Cruz
Faculty Research, Scholarly, and Creative Activity
Coastal cities face critical challenges in managing ozone pollution because of high population density and complex interactions between urbanization and coastal meteorology. Using New York City (NYC) as a case study, this work examines how urban surfaces influence heatwaves, sea-breeze circulations, and boundary-layer dynamics, and how these processes shape nitrogen dioxide ((Formula presented.)) distributions and ozone formation. Observations from the 2018 Long Island Sound Tropospheric Ozone Study (LISTOS), collected with an airborne high-resolution ultraviolet–visible spectrometer, provide tropospheric (Formula presented.) column densities for evaluating the Weather Research and Forecasting model coupled with Chemistry (WRF-Chem) in multiple urban canopy configurations. Results show …
Versatile Smad2 And Smad3 Epitope-Tagged Mouse Models For Genomic Profiling Of Tgfβ Signaling: Uncovering Gdf9-Smad2/3 Targets, Zian Liao, Qian Zhang, Keisuke Shimada, Kaori Nozawa, Suni Tang, Masahito Ikawa, Diana Monsivais, Martin M Matzuk
Versatile Smad2 And Smad3 Epitope-Tagged Mouse Models For Genomic Profiling Of Tgfβ Signaling: Uncovering Gdf9-Smad2/3 Targets, Zian Liao, Qian Zhang, Keisuke Shimada, Kaori Nozawa, Suni Tang, Masahito Ikawa, Diana Monsivais, Martin M Matzuk
Faculty, Staff and Students Publications
Transforming growth factor β (TGFβ) signaling pathways are integral for a plethora of biological processes. SMAD2 and SMAD3 are the principal transcriptional effectors of TGFβ superfamily ligands, yet quantitative, genome-wide mapping of their DNA-associated complexes under physiological contexts has remained limited due to the lack of specific, robust models. Here, we generated two versatile epitope-tagged mouse models in which endogenous SMAD2 and SMAD3 proteins are globally tagged with hemagglutinin (HA) and podoplanin (PA) sequences, respectively, enabling high-fidelity profiling of SMAD2 and SMAD3 binding across tissues. To demonstrate the broad application of our models, we exemplified the usage of our lines …
Relative Impact Of Multidomain Lifestyle Interventions On Deficit Accumulation Frailty Over 24 Months In The U.S. Pointer Trial, Mark A Espeland, Kayloni Olson, Christy C Tangney, Darren R Gitelman, Maryjo Cleveland, Amber A Thro, Yitbarek N Demesie, Heather M Snyder, Rachel A Whitmer, Pankaja Desai, Rifat Alam, Lucia Crivelli, Thomas M Holland, Olivia Preissle, Rema Raman, Michele K York, Laura D Baker
Relative Impact Of Multidomain Lifestyle Interventions On Deficit Accumulation Frailty Over 24 Months In The U.S. Pointer Trial, Mark A Espeland, Kayloni Olson, Christy C Tangney, Darren R Gitelman, Maryjo Cleveland, Amber A Thro, Yitbarek N Demesie, Heather M Snyder, Rachel A Whitmer, Pankaja Desai, Rifat Alam, Lucia Crivelli, Thomas M Holland, Olivia Preissle, Rema Raman, Michele K York, Laura D Baker
Faculty, Staff and Students Publications
Background: Multidomain lifestyle interventions hold promise as approaches to slow aging. Deficit accumulation frailty indices (FIs) are increasingly used to capture aging processes. Frailty is highly associated with increased mortality and chronic disease risk, but the degree to which multidomain lifestyle changes impact frailty is not clear.
Methods: The U.S. Study to Protect Brain Health through Lifestyle Intervention to Reduce Risk (U.S. POINTER) was a 2-year randomized clinical trial to compare two multidomain lifestyle interventions designed to increase exercise, improve diet, and promote social and cognitive stimulating activities and health monitoring. The Structured intervention incorporated greater structure, intensity, and accountability …
Goals And Budgets: An Exploratory Study Of Sequencing In Budget Simulation Engagement, Frankline Muthomi
Goals And Budgets: An Exploratory Study Of Sequencing In Budget Simulation Engagement, Frankline Muthomi
Public Administration Faculty Publications and Presentations
Purpose:
The purpose of this study is to examine how the sequencing of budget simulations influences the alignment between priority goals and budgetary decisions. Drawing on behavioral perspectives, the study posits that two simulation sequences—goal setting to budgeting (default) and budgeting to goal setting (alternative)—shape individuals' budgetary responses, particularly the proximity between a program's total cost and the corresponding budgetary allocations. Design/methodology/approach This study employs a quasi-experimental research design using Balancing Act modules that enable participants to articulate their priority goals and corresponding resource allocations. Adult Americans (aged 18 and above) were recruited through an online crowdsourcing platform and randomly …
Developing Endpoints For The Cardiac Burden In Myotonic Dystrophy Type 1: A Workshop Report, Julia M Hartman, Samuel Carrell, William J Groh, Thomas A Cooper, Jordana Kron, Greg Hundley, Jennifer Jordan, Amy Ladd, Man Hung, Nicholas E Johnson
Developing Endpoints For The Cardiac Burden In Myotonic Dystrophy Type 1: A Workshop Report, Julia M Hartman, Samuel Carrell, William J Groh, Thomas A Cooper, Jordana Kron, Greg Hundley, Jennifer Jordan, Amy Ladd, Man Hung, Nicholas E Johnson
Faculty, Staff and Students Publications
Cardiac disease is a well-established manifestation of myotonic dystrophy type 1 (DM1), characterized by progressive cardiac conduction slowing with increased risk of atrial and ventricular arrhythmias, heart block, and sudden cardiac death. Multiple disease modifying therapies are in clinical trials for DM1 and show promise in improving skeletal muscle weakness and myotonia. Testing the effects of these medicines, or others, in the heart is of critical importance, but requires identification of endpoints of cardiac function that accurately reflect the state of DM1 cardiac disease. To better define cardiac endpoints, the Myotonic Dystrophy Clinical Research Network (DMCRN) and the Myotonic Dystrophy …
Structure-Preserving Multivariate Hypothesis Testing For Mass Spectrometry Imaging And Single-Cell Data, Keziah E Liebenberg, Erin Craig, Robert Tibshirani, Livia S Eberlin
Structure-Preserving Multivariate Hypothesis Testing For Mass Spectrometry Imaging And Single-Cell Data, Keziah E Liebenberg, Erin Craig, Robert Tibshirani, Livia S Eberlin
Faculty, Staff and Students Publications
Motivation: Mass spectrometry imaging (MSI) and single-cell RNA sequencing (scRNA-seq) offer high-resolution views into tissue and cellular heterogeneity. However, conventional statistical analyses often treat sub-measurements (pixels or cells) as independent, ignoring their nested origin from individual samples. This assumption inflates the effective sample size, increases false discoveries, and undermines biological interpretation. Pixel- or cell-level averaging avoids this but sacrifices spatial or cellular resolution.
Results: We evaluated block-SAM on both simulated and real-world datasets. In DESI-MSI data from kidney, lung, and ovarian tumors, block-SAM consistently identified fewer-but more reliable-differential features compared to traditional-SAM. For example, in the kidney dataset, traditional-SAM identified …
Transforming Sexual And Reproductive Health And Rights For Adolescent Girls In West And Central Africa, Mame Soukeye Mbaye, Sarah Engebretsen, Maty Dia, Karen Austrian
Transforming Sexual And Reproductive Health And Rights For Adolescent Girls In West And Central Africa, Mame Soukeye Mbaye, Sarah Engebretsen, Maty Dia, Karen Austrian
Adolescents and Young People
This brief summarizes the evidence on adolescent girls’ sexual and reproductive health and rights (SRHR) in West and Central Africa (WCA), particularly evidence from the GIRL Center’s priority countries. It explores social norms and structural barriers to adolescent girls’ SRHR, pregnancy, harmful practices, unmet need for contraception, service gaps, SRHR in conflict settings, and legal and policy barriers. The brief informs strategies and promising entry points that have the potential to transform SRHR outcomes for girls in the region.
Accelerating Adolescent Girls’ Education In West And Central Africa, Mame Soukeye Mbaye, Sarah Engebretsen, Maty Dia, Karen Austrian
Accelerating Adolescent Girls’ Education In West And Central Africa, Mame Soukeye Mbaye, Sarah Engebretsen, Maty Dia, Karen Austrian
Adolescents and Young People
This brief summarizes the evidence on gender inequality in education in West and Central Africa (WCA), particularly the GIRL Center’s priority countries. It explores attendance, progression, transition to secondary, and re-entry. This brief informs strategies that address persistent inequalities and promote transformative outcomes for adolescent girls in the region.
Reference Proteins To Improve Core 1 And Core 2 Alzheimer's Disease Csf And Plasma Biomarkers, Linda Karlsson, Nicolas R Barthélemy, Kanta Horie, Suzanne E Schindler, Brian A Gordon, Cyrus A Raji, Tammie L S Benzinger, John C Morris, Randall J Bateman, Et Al.
Reference Proteins To Improve Core 1 And Core 2 Alzheimer's Disease Csf And Plasma Biomarkers, Linda Karlsson, Nicolas R Barthélemy, Kanta Horie, Suzanne E Schindler, Brian A Gordon, Cyrus A Raji, Tammie L S Benzinger, John C Morris, Randall J Bateman, Et Al.
2020-Current year OA Pubs
Concentration-based fluid biomarkers represent an informative and cost-effective way to detect and monitor Alzheimer's disease (AD) pathology. However, non-AD-related interindividual variation in biofluids can also affect biomarker concentrations. Here, we investigated whether normalization of CSF and plasma biomarkers to reference proteins, such as amyloid-β40 (Aβ40) and non-phosphorylated mid-region tau (np-tau), improves their robustness and reliability of representing AD pathology load. Using the Swedish BioFINDER-2 cohort [n = 1702, 50.7% male, mean (standard deviation) age 68.4 (12.2) years], we compared the associations between tau/Aβ-PET load and fluid biomarkers alone versus biomarkers in a ratio with a reference protein (Aβ40 or np-tau) …
Validate-Perianal: An International Real-World Multi-Centre Exploratory Validation Of The Topclass Definition Of A Radiologically Healed Fistula In Perianal Fistulising Crohn's Disease, Easan Anand, Thirza J Van Croonenburg, Sami Samaan, Phil Tozer, Ailsa Hart, Parakkal Deepak, David H Ballard, Jaap Stoker, Phillip Lung
Validate-Perianal: An International Real-World Multi-Centre Exploratory Validation Of The Topclass Definition Of A Radiologically Healed Fistula In Perianal Fistulising Crohn's Disease, Easan Anand, Thirza J Van Croonenburg, Sami Samaan, Phil Tozer, Ailsa Hart, Parakkal Deepak, David H Ballard, Jaap Stoker, Phillip Lung
2020-Current year OA Pubs
OBJECTIVES: Radiological healing on MRI is the ultimate therapeutic goal in Class 2a perianal fistulising Crohn's disease (pfCD). The TOpClass consortium recently defined radiological healing (TOpClass-RH) by the absence of T2 hyperintensity, a completely fibrotic fistula tract, and the absence of contrast enhancement when used. This study aimed to validate TOpClass-RH in real-world clinical practice.
MATERIALS AND METHODS: VALIDATE-PERIANAL was a retrospective, multi-centre international study. Patients with pfCD with a baseline MRI scan showing active disease and follow-up MRI evidence of radiological fistula healing between 2021 and 2023 were identified. Paired scans were independently reviewed by three gastrointestinal radiologists using …
Development And Feasibility Testing Of A Video-Based Virtual Reality Bullying Safety Skills Intervention For School-Aged Children With Disabilities, Trevor C. Maxfield
Development And Feasibility Testing Of A Video-Based Virtual Reality Bullying Safety Skills Intervention For School-Aged Children With Disabilities, Trevor C. Maxfield
USF Tampa Graduate Theses and Dissertations
Virtual reality (VR) technology has emerged as a promising instructional tool for children with disabilities; however, research on using VR to improve safety skills in this population remains limited. The present study employed a 2-phase approach to develop and evaluate a video-based VR bullying safety skills intervention for children with disabilities. In Phase 1, bullying and applied behavior analysis experts reviewed and validated the intervention content, including the response to bullying steps, school-based scenario storyboards, and embedded behavioral procedures, rating the content as valid and technically adequate. Expert feedback informed refinements to the intervention content and the decision to transition …