Digital Commons Network^™

A Piezoelectric Gelatin Scaffold For Schwann Cell Induced Spinal Cord Repair, Scott Stratton

Dissertations

Spinal cord injury (SCI) results in axonal damage and consequently, functional loss for which there is no effective treatment at the present time. Axon growth across the injured site is needed to restore disruptive axonal circuitry, which is needed for recovery of lost function, but endogenous axon growth is poor. A Schwann cell (SC) transplant has shown promise in promoting axon growth in the injured spinal cord. Similarly, it has been shown that axons grow into biomaterial conduits especially when they are engineered to provide physical and biochemical growth-promoting cues. While both approaches are promising, their overall effect on axon …

Preemption In State Tobacco Minimum Legal Sales Age Laws In The Us, 2022: A Policy Analysis Of State Statutes And Case Laws, Page D. Dobbs, Ginny Chadwich, Eric Crosbie, Jessica Breslin, Lisa Henriksen

Health, Human Performance and Recreation Faculty Publications and Presentations

Preemptive statutory language within tobacco minimum legal sales age (MLSA) laws has prohibited localities from enacting stricter laws than state statutes. With the recent uptake of state Tobacco 21 laws in the US, the current landscape of preempted MLSA laws is unknown. This study sought to update the status of preemption in MLSA laws enacted in US states between 2015–2022. A public health attorney reviewed state tobacco MLSA laws (n = 50) and state tobacco control codes, searching for language regarding preemption. When statutes were unclear, case law was reviewed by examining local ordinances that were invalidated by state court …

Why The Other-Race Effect Matters: Poor Recognition Of Other-Race Faces Impacts Everyday Social Interactions, Elinor Mckone, Amy Dawel, Rachel A. Robbins, Yiyun Shou, Nan Chen, Kate Crookes

Research outputs 2022 to 2026

What happens to everyday social interactions when other-race recognition fails? Here, we provide the first formal investigation of this question. We gave East Asian international students (N = 89) a questionnaire concerning their experiences of the other-race effect (ORE) in Australia, and a laboratory test of their objective other-race face recognition deficit using the Cambridge Face Memory Test (CFMT). As a ‘perpetrator’ of the ORE, participants reported that their problems telling apart Caucasian people contributed significantly to difficulties socializing with them. Moreover, the severity of this problem correlated with their ORE on the CFMT. As a ‘victim’ of the ORE, …

The Vitamin D Serum Levels In Pregnant Women Affected By Covid-19: A Systematic Review And Meta-Analysis, Luiza Szarpak, Stepan Feduniw, Michal Pruc, Michal Ciebiera, Basar Cander, Mansur Rahnama-Hezavah, Łukasz Szarpak

Faculty, Staff and Students Publications

Vitamin D can modulate immune responses, and its deficiency is linked to increased autoimmunity and susceptibility to infection. In the general population, it has been observed that serum vitamin D levels are connected with the risk of COVID-19 and its severity. Our study aims to examine reported findings on the effect of vitamin D serum levels on infection of COVID-19 during pregnancy. PubMed, Web of Science, Embase, and Cochrane Library were searched for relevant studies. Serum vitamin D serum levels in COVID-19-positive and COVID-19-negative pregnant women were 24.61 ± 20.86 ng/mL and 24.12 ± 17.33 ng/mL, respectively. In mild vs. …

The Efficiency Of P27 Cleavage During In Vitro Respiratory Syncytial Virus (Rsv) Infection Is Cell Line And Rsv Subtype Dependent, Wanderson Rezende, Xunyan Ye, Laura S Angelo, Alexandre F Carisey, Vasanthi Avadhanula, Pedro A Piedra

Faculty, Staff and Students Publications

Respiratory syncytial virus (RSV) fusion protein (F) is highly conserved between subtypes A and B (RSV/A and RSV/B). To become fully active, F precursor undergoes enzymatic cleavage to yield F1 and F2 subunits and releases a 27-amino-acid peptide (p27). Virus-cell fusion occurs when RSV F undergoes a conformational change from pre-F to post-F. Previous data show that p27 is detected on RSV F, but questions remain regarding if and how p27 affects the conformation of mature RSV F. Monoclonal antibodies against p27, site Ø (pre-F specific), and site II were used to monitor RSV F conformation by enzyme-linked immunosorbent assay …

Hrd Effects On First-Line Adjuvant Chemotherapy And Parpi Maintenance Therapy In Chinese Ovarian Cancer Patients, Lei Li, Yu Gu, Mengpei Zhang, Xiaohua Shi, Zhe Li, Xinyun Xu, Tianqi Sun, Yu Dong, Chao Xue, Xiaoru Zhu, Ran Lv, Kai Jiao, Xuwo Ji, Li-Juan Wang, Yang Zhang, Zhiyong Liang, Ying Jin, Rutie Yin, Ming Wu, Han Liang

Faculty, Staff and Student Publications

Homologous recombination deficiency (HRD) testing has been approved by FDA for selecting epithelial ovarian cancer (EOC) patients who may benefit from the first-line poly (ADP-ribose) polymerase inhibitor (PARPi) maintenance therapy. However, the effects of HRD on the clinical outcomes of first-line chemotherapy and first-line PARPi maintenance therapy have not been rigorously evaluated in Chinese EOC patients. Here, we developed an HRD assay and applied it to two large retrospectively collected Chinese EOC patient cohorts. In the first-line adjuvant chemotherapy cohort (FACT, N = 380), HRD status significantly improved PFS (median, 15.6 months vs. 9.4 months; HR, 0.688; 95% CI, 0.526-0.899; …

Heritable Aortic Root Aneurysms, Maral Ouzounian, Scott A Lemaire, Dianna M Milewicz

Faculty, Staff and Student Publications

No abstract provided.

Leukemia Relapse Via Genetic Immune Escape After Allogeneic Hematopoietic Cell Transplantation, Simona Pagliuca, Francesca Ferraro, Et Al.

2020-Current year OA Pubs

Graft-versus-leukemia (GvL) reactions are responsible for the effectiveness of allogeneic hematopoietic cell transplantation as a treatment modality for myeloid neoplasia, whereby donor T- effector cells recognize leukemia neoantigens. However, a substantial fraction of patients experiences relapses because of the failure of the immunological responses to control leukemic outgrowth. Here, through a broad immunogenetic study, we demonstrate that germline and somatic reduction of human leucocyte antigen (HLA) heterogeneity enhances the risk of leukemic recurrence. We show that preexistent germline-encoded low evolutionary divergence of class II HLA genotypes constitutes an independent factor associated with disease relapse and that acquisition of clonal somatic …

Healthcare Provider Perspectives On Hiv Cure Research In Ghana, Helena Lamptey, Benjamin Newcomb, Evelyn Y Bonney, James O Aboagye, Peter Puplampu, Vincent J Ganu, Gloria Ansa, Joseph Oliver-Commey, George B Kyei

2020-Current year OA Pubs

INTRODUCTION: Antiretroviral therapy (ART) has reduced mortality and improved life expectancy among HIV patients but does not provide a cure. Patients must remain on lifelong medications and deal with drug resistance and side effects. This underscores the need for HIV cure research. However, participation in HIV cure research has risks without guaranteed benefits. We determined what HIV healthcare providers know about HIV cure research trials, the risks involved, and what kind of cure interventions they are likely to recommend for their patients.

METHODS: We conducted in-depth qualitative interviews with 39 HIV care providers consisting of 12 physicians, 8 counsellors, 14 …

Irritability Moderates The Association Between Cognitive Flexibility Task Performance And Related Prefrontal Cortex Activation In Young Children, Yanwei Li, Adam S Grabell, Susan B Perlman

2020-Current year OA Pubs

The association between cognitive flexibility and related neural functioning has been inconsistent. This is particularly true in young children, where previous studies have found heterogenous results linking behavior and neural function, raising the possibility of unexplored moderators. The current study explored the moderating role of dimensional irritability in the association between cognitive flexibility task performance and prefrontal activation in young children. A total of 106 3- to 7-year-old children were recruited to complete a custom-designed, child-adapted, cognitive flexibility task, and 98 of them were included in the data analysis. The children's dorsolateral prefrontal cortex activation was monitored using functional near-infrared …

Neuron-Associated Macrophage Proliferation In The Sensory Ganglia Is Associated With Peripheral Nerve Injury-Induced Neuropathic Pain Involving Cx3cr1 Signaling, Rafaela M Guimarães, Conceição E Aníbal-Silva, Marcela Davoli-Ferreira, Francisco Isaac F Gomes, Atlante Mendes, Maria C M Cavallini, Miriam M Fonseca, Samara Damasceno, Larissa P Andrade, Marco Colonna, Cyril Rivat, Fernando Q Cunha, José C Alves-Filho, Thiago M Cunha

2020-Current year OA Pubs

Resident macrophages are distributed across all tissues and are highly heterogeneous due to adaptation to different tissue-specific environments. The resident macrophages of the sensory ganglia (sensory neuron-associated macrophages, sNAMs) are in close contact with the cell body of primary sensory neurons and might play physiological and pathophysiological roles. After peripheral nerve injury, there is an increase in the population of macrophages in the sensory ganglia, which have been implicated in different conditions, including neuropathic pain development. However, it is still under debate whether macrophage accumulation in the sensory ganglia after peripheral nerve injury is due to the local proliferation of …

Dissociation Protocols Used For Sarcoma Tissues Bias The Transcriptome Observed In Single-Cell And Single-Nucleus Rna Sequencing, Danh D Truong, Salah-Eddine Lamhamedi-Cherradi, Robert W Porter, Sandhya Krishnan, Jyothishmathi Swaminathan, Amber Gibson, Alexander J Lazar, J Andrew Livingston, Vidya Gopalakrishnan, Nancy Gordon, Najat C Daw, Nicholas E Navin, Richard Gorlick, Joseph A Ludwig

Faculty, Staff and Student Publications

BACKGROUND: Single-cell RNA-seq has emerged as an innovative technology used to study complex tissues and characterize cell types, states, and lineages at a single-cell level. Classification of bulk tumors by their individual cellular constituents has also created new opportunities to generate single-cell atlases for many organs, cancers, and developmental models. Despite the tremendous promise of this technology, recent evidence studying epithelial tissues and diverse carcinomas suggests the methods used for tissue processing, cell disaggregation, and preservation can significantly bias gene expression and alter the observed cell types. To determine whether sarcomas - tumors of mesenchymal origin - are subject to …

System, Method, And Computer Program Product For Automatically Scraping Categorical Data From A Plurality Of Websites, Patrick Ryan Flanagan, Piers William Butler Clough

Defensive Publications Series

Systems, methods, and computer program products are provided for automatically scraping categorical data from a plurality of websites. These include: determining a product category; identifying a first website including data associated with the product category; automatically scraping the first website to compile first product data associated with the product category; generating a plurality of web queries based on the compiled first product data; executing the plurality of web queries to identify a plurality of websites; automatically scraping at least a portion of the plurality of websites to compile supplier data associated with suppliers in the product category; and storing at …

Indications For Signalling The Presence Of A Private 5g Network, Roberta Maglione, Gioacchino Castorio, Suresh Krishnan, Josh Halley, Neha Pradeep

Defensive Publications Series

Private 3rd Generation Partnership Project (3GPP) fifth-generation (5G), or Private 5G (P5G), networks are local networks or local area networks (LANs) that are built using 3GPP 5G wireless technology to carry traffic within a specified area, such as within an organization, on a campus, or within an industrial space. A growing number of enterprise and public sector companies are considering building their own P5G networks to address their need for clean spectrum, high bandwidth, low latency, higher availability, and increased visibility. With the introduction of P5G networks, there may be scenarios where both Wi-Fi and P5G networks are present in …

Collective Musical Cognition: Relevance, Dialogue, And Reflection In Group Learning, Leonore Pogonowski, Cindy Bell, Nathalie Robinson

Visions of Research in Music Education

The purpose of this article is to introduce collective musical cognition as a mode for developing diagnostic critical thinking in music at all levels of the educa-tional continuum–kindergarten through graduate school. It defines and illustrates how collective musical cognition is influenced by relevance, dialogue, and reflection as social and educational practices in the classroom. Relevance, dialogue, and reflection - the three components of collective musi-cal cognition–are critical social practices that transform music education pedagogy, whether practiced in the orchestral rehearsal room, the general music classroom, or the choral and band rehearsal rooms. The prevailing idea is student engagement: student engagement …

A Personal Retrospective On The Mmcp, Leonore Pogonowski

Visions of Research in Music Education

Reprint with permission by National Association for Music Education. Original citation: Pogonowski, L. (2001). A personal retrospective on the MMCP. Music Educators Journal 88(1), 24-27+52.

The Creative Arts Laboratory: My Model For School-University Partnerships, Gena R. Greher

Visions of Research in Music Education

The Creative Arts Laboratory (CAL) was the embodiment of Lee Pogonowski’s teaching philosophy and an outgrowth of her work with the Manhattanville Music Curriculum Project (MMCP). Through frequent workshops and weekly in-class mentoring by CAL Teaching Artists, CAL facilitated teachers' capacities to help students make connections across subject matter areas. In this article I discuss how CAL as a professional development model for integrating the arts into the school curriculum, formed the basis of many of the School-University Partnerships, I developed to connect pre-service music education students with in-service music teachers. Through our partnerships, our students are learning what I …

The Extraordinary Legacy Of Lee Pogonowski, Richard Carr

Visions of Research in Music Education

This article is a memoir of the author’s experience studying music education at Teachers College Columbia University with Professor Lenore Pogonowski in the mid 1990s. The author completed four years of study at that institution earning an MA. Ed.M., and an Ed.D. He was also a teaching artist for the Creative Arts Laboratory, a US government funded program headed by Dr. Pogonowski, during that time. Professor Pogonowski had a profound impact on the author’s teaching practice during the ensuing decades. In his interactions with other music educators, he was surprised to learn how many of them were trained in a …

Lessons From The Stairwell: Celebrating And Sustaining The Pedagogical Legacy Of Lee Pogonowski, Shane Bordeau

Visions of Research in Music Education

As a teacher and researcher of music education for more than forty years, Lee Pogonowski was an early voice in disrupting traditional approaches to teaching and learning, inviting student-centered approaches that emphasized music as an aesthetic experience (Biasini & Pogonowski, 1969; Pogonowski, 2001). The influence of her work continues to reverberate throughout the field of music education, through the legacy of her impact on her students (Allsup, & Baxter, 2004; Greher, 2004; Robinson et al., 2011). Reflections on this legacy, through stories and memories of experiences in her classroom serve as a reminder and challenge to continue and expand the …

A Tribute To Dr. Lee Pogonowski: A Visionary Music Teacher Educator, Shawn Amdur

Visions of Research in Music Education

The insights, writings, and teachings of Dr. Lenore Pogonowski are highlighted with references to the beginnings of her Creative Music Strategies at Teachers College. Based on her work with the Manhattanville Music Curriculum Project (MMCP) there was an emphasis on 20th Century compositional techniques, the use of recorded and environmental sounds as well as the importance of free exploration.

Lee Pogonowski And The Art Of Instruction, Randall Everett Allsup

Visions of Research in Music Education

This essay concerns the educational legacy of Professor Lenore (Lee) Pogonowski, who passed away in early 2022 after a long career of teaching music education at Teachers College Columbia University. In this manuscript, I discuss the instructional design model that Lee Pogonowski called the “creative music strategy.” Her greatest achievement, most will agree, was her ability to inspire creativity while modeling the implementation of this instructional model. Pogonowski’s beliefs about the ineffability of the creative classroom aligned with her refusal to fix its instructional processes through the inherent linearity of the printed word. She did, however, leave her university students …

Preface, Nathalie Robinson

Visions of Research in Music Education

This Preface is a cherished personal memory of my dear friend, colleague, and mentor, Lenore (Lee) Pogonowski. It provides a glimpse of Lee as a young college professor in the early 1970s at Western Connecticut State University, when she was integrating and expanding her knowledge gleaned from her work with the Manhattanville Music Curriculum Project into the development of a new curricular approach for teaching college freshman music education majors. Her thinking about the teaching-learning process was years ahead of its time and a small group of us were the beneficiaries of this tremendous gift. Every author in this Journal …

Editorial: Musical Thinking, Thinking About Thinking And So Many A-Ha Moments!, Elissa Johnson-Green, Gena R. Greher

Visions of Research in Music Education

No abstract provided.

Ip Protection For Love: Dating App’S Feuds And Foes, Meredith Williams

Journal of Intellectual Property Law

A new method of meeting others and dating online has emerged amid today’s age of technology. Online dating, now largely facilitated through apps, has grown exponentially since its genesis. With this growth, online dating services have sought intellectual property protection. This Note examines the patentability of dating app features, primarily the digital user interface through the backdrop of a recent dispute between Tinder and Bumble. It begins with a history of online dating and analysis of why apps have become a popular tool to launch a business. The Note then delves into a new dating app concept and accompanying patent …

Give Starving Artists A Piece Of The Ip Pie: Making Room At The Table For Performers’ Rights, Meagan A. Sharp

Journal of Intellectual Property Law

Creators protect their valuable intellectual property interests through copyright. Historically, stage performers struggled to secure copyright ownership in their performances within a larger production. As the theatre landscape changes, however, trends indicate that producers will increasingly rely on performers to develop characters and shows. This reliance could prove to be an exploitative practice if performers do not receive additional compensation for their part in creating successful works. This Note first examines the meanings of authorship, fixation, and control under the Copyright Act of 1976, then widens its lens to consider alternate interpretations of these technical terms in light of an …

Transparency Is The Best Policy: The Case For Georgia To Allow Access To The Source Code Of Proprietary Voting Software, Grace Repella

Journal of Intellectual Property Law

Within the past century, electronic voting systems have become common place. Most states hold their elections via electronic voting machines. These voting machines require software, and that software is built out of source code. Most states, including the state of Georgia, use voting machines with proprietary software made by private companies to run their elections. These companies have pushed back against access to the source code of their software because of intellectual property issues related to trade secret and copyright law. Nonetheless, states have an interest in guaranteeing their elections are not vulnerable to attack or hacking, and voters want …

Architectural Copyrights: The Eighth Circuit's Structurally Sound Interpretation Of 17 U.S.C. § 120, Hunter T. Payne

Journal of Intellectual Property Law

The Eighth Circuit expanded architectural copyright protection in Designworks Homes, Inc. v. Columbia House of Brokers Realty, Inc., by interpreting § 17 U.S.C. 120(a) consistent with both its plain meaning and legislative intent. In doing so, the court took a pivotal step in protecting architects’ copyright interest in floorplans posted on virtual real estate websites without consent. The National Association of Realtors quickly took offense, declaring this an invitation to waves of litigation, hindering the current state of real estate transactions that often occur via websites like Zillow or Redfin. However, as highlighted by the Eighth Circuit, copyright fair use …

To "The" Or Not To "The"? The Question Has Been Answered: An Examination Of Trademark Bullying In The Context Of The Ohio State University's Recent Trademark Registration, Jennifer M. Danker

Journal of Intellectual Property Law

This Note examines the growing concern in the legal community around trademark bullying by specifically focusing on the registration of the word mark “THE” by The Ohio State University (“OSU”) and its potential for abuse and overreach in trademark enforcement. By carefully analyzing relevant legal precedent, statutory provisions, and USPTO administrative procedures, this Note critically considers the offered justifications for and likely consequences of the trademark’s registration.

By exploring the historical progression of trademark law, including its purpose and underlying principles, this Note provides a framework for evaluating the merits and potential concerns associated with the recent registration. Additionally, it …

From America Online To America, Online: Reassessing Section 230 Immunity In A New Internet Landscape, Madeleine E. Blair

Journal of Intellectual Property Law

In 1996, Congress passed the Communications Decency Act, a body of legislation aimed at regulating a nascent internet. Section 230 of the Act has become a subject of contention on both sides of the political aisle due to an immunity provision in the law barring private actions against online service providers for the conduct of those services’ users. Few lawsuits against online entities have survived this immunity provision. But two successful cases, Lemmon v. Snap, Inc. and A.M. v. Omegle.com, LLC, have used a products liability theory to overcome the limitation.

This Note examines Section 230 in light of these …

Rethinking "Reasonableness": Implementation Of A National Board To Clarify The Trade Secret Standard Now That The Work-From-Home Culture Has Changed The Rules, Hannah E. Brown

Journal of Intellectual Property Law

Under the federal Defend Trade Secrets Act (“DTSA”), almost any type of information can qualify as a trade secret but only if the owner has taken “reasonable measures” to keep such information secret. Under case law, what is “reasonable” varies and may differ based on the court, the company size, and the particular facts of each situation. The interpretation of what is “reasonable” must change with the times, specifically, to take into consideration the sharp increase in remote work that accompanied the COVID-19 pandemic. The rise in remote work necessarily means more servers accessing data and more remote transmission of …