Digital Commons Network^™

Copus Profiles Paper Data, Jamie Jensen, Rebecca L. Sansom, Jennifer B. Nielson, Richard E. West, Geoffrey Wright, Bryn St. Clair

ScholarsArchive Data

COPUS profile data, interview transcripts

Whole-Genome Sequencing Analysis Of Human Metabolome In Multi-Ethnic Populations, Elena V Feofanova, Michael R Brown, Taryn Alkis, Astrid M Manuel, Xihao Li, Usman A Tahir, Zilin Li, Kevin M Mendez, Rachel S Kelly, Qibin Qi, Han Chen, Martin G Larson, Rozenn N Lemaitre, Alanna C Morrison, Charles Grieser, Kari E Wong, Robert E Gerszten, Zhongming Zhao, Jessica Lasky-Su, Bing Yu

Faculty, Staff and Student Publications

Circulating metabolite levels may reflect the state of the human organism in health and disease, however, the genetic architecture of metabolites is not fully understood. We have performed a whole-genome sequencing association analysis of both common and rare variants in up to 11,840 multi-ethnic participants from five studies with up to 1666 circulating metabolites. We have discovered 1985 novel variant-metabolite associations, and validated 761 locus-metabolite associations reported previously. Seventy-nine novel variant-metabolite associations have been replicated, including three genetic loci located on the X chromosome that have demonstrated its involvement in metabolic regulation. Gene-based analysis have provided further support for seven …

Towards Generalizable Machine Learning Models For Computer-Aided Diagnosis In Medicine, Yiyang Wang

College of Computing and Digital Media Dissertations

Hidden stratification represents a phenomenon in which a training dataset contains unlabeled (hidden) subsets of cases that may affect machine learning model performance. Machine learning models that ignore the hidden stratification phenomenon--despite promising overall performance measured as accuracy and sensitivity--often fail at predicting the low prevalence cases, but those cases remain important. In the medical domain, patients with diseases are often less common than healthy patients, and a misdiagnosis of a patient with a disease can have significant clinical impacts. Therefore, to build a robust and trustworthy CAD system and a reliable treatment effect prediction model, we cannot only pursue …

Criminal Justice Reform And The Centrality Of Intent, Cynthia V. Ward

Villanova Law Review (1956 - )

No abstract provided.

Democratizing Tthe Eighth Amendment, Erin E. Braatz

Villanova Law Review (1956 - )

No abstract provided.

Stacking The Deck: How The Eighth Circuit's Decision In United States V. Crandall Threatens The First Step Act's Bipartisan Criminal Justice Reforms, Anthony Passela

Villanova Law Review (1956 - )

No abstract provided.

There's No Place Like Home: The Second Circuit Disturbs Fourth Amendment Protections In Torcivia V. Suffolk County, Jillian E. Sprong

Villanova Law Review (1956 - )

No abstract provided.

Reorientation, Soleil Nguyen

Masters Theses

A non-linear narrative to understand the place and character of my neighborhood.

The Influence Of Internal Marketing On Employee Performance In The Ghanaian Public Sector: The Mediating Role Of Organizational Commitment, Francis Osei, Alfred Owusu, Collins Kankam-Kwarteng, Gertrude Agyemang

BISNIS & BIROKRASI: Jurnal Ilmu Administrasi dan Organisasi

This research assessed the influence of internal marketing on employee performance in the public sector of Ghana, as mediated by organizational commitment. This research was conducted on a total of 300 public sector workers in Ghana, of whom 200 responses were received, representing a response rate of 66.6%. Purposive and convenience sampling techniques were adopted. The PLS-SEM technique was implemented to determine the associations among the variables. The research results reveal significant associations among internal marketing, employee performance, and organizational commitment. Moreover, a partial role is played by organizational commitment. The research findings indicate that the public sector, particularly Metropolitan, …

Architecture Of Androgen Receptor Pathways Amplifying Glucagon-Like Peptide-1 Insulinotropic Action In Male Pancreatic Β Cells, Weiwei Xu, M M Fahd Qadir, Daniela Nasteska, Paula Mota De Sa, Caroline M Gorvin, Manuel Blandino-Rosano, Charles R Evans, Thuong Ho, Evgeniy Potapenko, Rajakrishnan Veluthakal, Fiona B Ashford, Stavroula Bitsi, Jia Fan, Manika Bhondeley, Kejing Song, Venkata N Sure, Siva S V P Sakamuri, Lina Schiffer, Wandy Beatty, Rachael Wyatt, Daniel E Frigo, Xiaowen Liu, Prasad V Katakam, Wiebke Arlt, Jochen Buck, Lonny R Levin, Tony Hu, Jay Kolls, Charles F Burant, Alejandra Tomas, Matthew J Merrins, Debbie C Thurmond, Ernesto Bernal-Mizrachi, David J Hodson, Franck Mauvais-Jarvis

Faculty, Staff and Student Publications

Male mice lacking the androgen receptor (AR) in pancreatic β cells exhibit blunted glucose-stimulated insulin secretion (GSIS), leading to hyperglycemia. Testosterone activates an extranuclear AR in β cells to amplify glucagon-like peptide-1 (GLP-1) insulinotropic action. Here, we examined the architecture of AR targets that regulate GLP-1 insulinotropic action in male β cells. Testosterone cooperates with GLP-1 to enhance cAMP production at the plasma membrane and endosomes via: (1) increased mitochondrial production of CO

Progesterone From Ovulatory Menstrual Cycles Is An Important Cause Of Breast Cancer, Herjan J T Coelingh Bennink, Iman J Schultz, Marcus Schmidt, V Craig Jordan, Paula Briggs, Jan F M Egberts, Kristina Gemzell-Danielsson, Ludwig Kiesel, Kirsten Kluivers, Jan Krijgh, Tommaso Simoncini, Frank Z Stanczyk, Robert D Langer

Faculty, Staff and Student Publications

Many factors, including reproductive hormones, have been linked to a woman's risk of developing breast cancer (BC). We reviewed the literature regarding the relationship between ovulatory menstrual cycles (MCs) and BC risk. Physiological variations in the frequency of MCs and interference with MCs through genetic variations, pathological conditions and or pharmaceutical interventions revealed a strong link between BC risk and the lifetime number of MCs. A substantial reduction in BC risk is observed in situations without MCs. In genetic or transgender situations with normal female breasts and estrogens, but no progesterone (P4), the incidence of BC is very low, suggesting …

What Regenerative Agriculture Can Teach Medical Students About Human Health, David Ebbott, Dimitrios Papanagnou

Department of Emergency Medicine Faculty Papers

No abstract provided.

Thermal Transport And Physical Characteristics Of Silver-Reinforced Biodegradable Nanolubricant, Jaime Taha-Tijerina, Karla Aviña, Nicolás Antonio Ulloa-Castillo, Dulce Viridiana Melo-Maximo

Informatics and Engineering Systems Faculty Publications

In this investigation, the thermal transport behavior of biodegradable lubricant reinforced with silver nanostructures (AgNs) at various filler fractions of 0.01, 0.05, 0.10, and 0.20 weight percent was evaluated over a temperature scan analysis, ranging from room temperature up to 60 °C. The experimental results revealed significant gradual enhancements in thermal conductivity as AgNs concentration and evaluating temperatures were increased. These improvements showed the important role of nanostructures’ interaction within the biodegradable lubricant. The thermal conductivity performance improved for nanolubricants ranging from 6.5% at 30 °C and 0.20 wt.% AgNs content up to a maximum 32.2%, which was obtained at …

Challenges In The Clinical Understanding Of Genetic Testing In Birth Defects And Pediatric Diseases, Tina O Findley, Jacqueline G Parchem, Aarti Ramdaney, Sarah U Morton

Faculty, Staff and Student Publications

Advances in prenatal/neonatal genetic screening practices and next generation sequencing (NGS) technologies have made the detection of molecular causes of pediatric diseases increasingly more affordable, accessible, and rapid in return of results. In the past, families searching for answers often required diagnostic journeys leading to delays in targeted care and missed diagnoses. Non-invasive prenatal NGS is now used routinely in pregnancy, significantly altering the obstetric approach to early screening and evaluation of fetal anomalies. Similarly, exome sequencing (ES) and genome sequencing (GS) were once only available for research but are now used in patient care, impacting neonatal care and the …

Self Management Programs And Its Effects On Blood Pressure, Thao Vo

Master of Science in Nursing Family Nurse Practitioner

No abstract provided.

Housing And Space Guidelines For Livestock, Kendall Kunelius

UNH Cooperative Extension

By using best management practices, farmers can greatly reduce or eliminate problems arising from odors and flies, pesticide drift, contamination of surface and ground waters, and damage to neighboring crops. Following best management practices can help eliminate problems that arise between farming activities and other land uses in urban environments.

Three New Majors Added For 2023-24, Julia Perez

News and Events (Discontinued Series)

No abstract provided.

Circadian Features Of Cluster Headache And Migraine: A Systematic Review, Meta-Analysis, And Genetic Analysis, Barlas Benkli, Sun Young Kim, Nobuya Koike, Chorong Han, Celia K Tran, Emma Silva, Yuanqing Yan, Kazuhiro Yagita, Zheng Chen, Seung-Hee Yoo, Mark J Burish

Faculty, Staff and Student Publications

BACKGROUND AND OBJECTIVES: Cluster headache and migraine have circadian features at multiple levels (cellular, systems, and behavioral). A thorough understanding of their circadian features informs their pathophysiologies.

METHODS: A librarian created search criteria in MEDLINE Ovid, Embase, PsycINFO, Web of Science, and Cochrane Library. Two physicians independently performed the remainder of the systematic review/meta-analysis using Preferred Reporting Items for Systematic Review and Meta-Analyses guidelines. Separate from the systematic review/meta-analysis, we performed a genetic analysis for genes with a circadian pattern of expression (clock-controlled genes or CCGs) by cross-referencing genome-wide association studies (GWASs) of headache, a nonhuman primate study of CCGs …

Glial Progenitor Heterogeneity And Key Regulators Revealed By Single-Cell Rna Sequencing Provide Insight To Regeneration In Spinal Cord Injury, Haichao Wei, Xizi Wu, Joseph Withrow, Raquel Cuevas-Diaz Duran, Simranjit Singh, Lesley S Chaboub, Jyotirmoy Rakshit, Julio Mejia, Andrew Rolfe, Juan J Herrera, Philip J Horner, Jia Qian Wu

Faculty, Staff and Student Publications

Recent studies have revealed the heterogeneous nature of astrocytes; however, how diverse constituents of astrocyte-lineage cells are regulated in adult spinal cord after injury and contribute to regeneration remains elusive. We perform single-cell RNA sequencing of GFAP-expressing cells from sub-chronic spinal cord injury models and identify and compare with the subpopulations in acute-stage data. We find subpopulations with distinct functional enrichment and their identities defined by subpopulation-specific transcription factors and regulons. Immunohistochemistry, RNAscope experiments, and quantification by stereology verify the molecular signature, location, and morphology of potential resident neural progenitors or neural stem cells in the adult spinal cord before …

Perceptions Of Health Workers Regarding The Covid-19 Vaccine Report Application In Ogan Ilir Regency, South Sumatra, Haerawati Idris, Amrina Rosyada, Anggun Budiastuti, Nurmalia Ermi

Journal of Indonesian Health Policy and Administration

The Lapor Vaksin COVID-19 Application was developed to support a vaccination coverage surveillance database sourced from community self-report. This application provides data on vaccination coverage and allows users to view updates to educational content about vaccines and visualization of COVID-19 vaccine data in real-time. This study aims to analyze the perception among health worker about Lapor Vaksin COVID-19 application in the community. This study uses descriptive research with a case study design. This study was conducted in September 2021 through a virtual zoom meeting, in Ogan Ilir Regency, South Sumatra. The research sample was 42 health workers consisting of vaccine …

Health Care Spending For Cardiovascular Disease Under National Health Insurance Scheme In Indonesia Before And During Covid-19: Descriptive Analysis And Policyrecommendations, Atik Nurwahyuni, Prastuti Soewondo, Mardiati Nadjib, Yuli Farianti, Mazda Novi Mukhlisa, Helmi Wahyuningsih, Emmy Ridhawaty Mangunsong, Athiyah Athiyah, Yunita Yunita, Sekar Arum Handarbeni Sayekti, Kurnia Sari, Amila Megraini

Journal of Indonesian Health Policy and Administration

The Cardiovascular disease (CVD) prevalence continues to increase. This study aims to identify the CVD spending and utilization in the Indonesia National Health Insurance (JKN) scheme 2017-2021 using the JKN claims classified by Disease Accounts analyzed descriptively. The CVD spending increased by $125,4 million in 2019 compared to 2017 and mostly for the hospital (91% in 2019) with the highest spending occurring in the age above 60 years. Moreover, the hospital inpatient spending was dominated during these five years. The highest portion of spending by severity level was at mild level, followed by moderate and severe levels. Health facilities’ capacities …

Reflections On Universities, Politics, And The Capitalist State: An Interdisciplinary And Intergenerational Discussion With Clyde W. Barrow, Clyde W. Barrow, Heather Steffen, Isaac Kamola

Political Science Faculty Publications

Since its publication in 1990, Clyde W. Barrow’s book, Universities and the Capitalist State: Corporate Liberalism and the Reconstruction of American Higher Education, 1894-1928, has been a touchstone text for generations of scholars studying higher education. This conversation between Barrow, Heather Steffen, and Isaac Kamola examines the book’s legacy in order to explore how the interdisciplinary study of higher education has changed over the past three decades. In doing so, they examine the space and place of academic knowledge and academic labor, offering an interdisciplinary discussion of critical praxis within the university.

A Hierarchical Cluster Approach Toward Understanding The Regional Variable In Country Conflict Modeling, Benjamin D. Leiby, Darryl K. Ahner

Faculty Publications

Purpose: This paper aims to examine how the regional variable in country conflict modeling affects forecast accuracy and identifies a methodology to further improve the predictions.

Design/methodology/approach: This paper uses statistical learning methods to both evaluate the quantity of data for clustering countries along with quantifying accuracy according to the number of clusters used.

Findings: This study demonstrates that increasing the number of clusters for modeling improves the ability to predict conflict as long as the models are robust.

Originality/value: This study investigates the quantity of clusters used in conflict modeling, while previous research assumes a specific quantity before …

The Metabolic Profile Of Young, Watered Chickpea Plants Can Be Used As A Biomarker To Predict Seed Number Under Terminal Drought, Sarah J Purdy, David Fuentes, Purushothaman Ramamoorthy, Christopher Nunn, Brent N Kaiser, Andrew Merchant

Faculty, Staff and Student Publications

Chickpea is the second-most-cultivated legume globally, with India and Australia being the two largest producers. In both of these locations, the crop is sown on residual summer soil moisture and left to grow on progressively depleting water content, finally maturing under terminal drought conditions. The metabolic profile of plants is commonly, correlatively associated with performance or stress responses, e.g., the accumulation of osmoprotective metabolites during cold stress. In animals and humans, metabolites are also prognostically used to predict the likelihood of an event (usually a disease) before it occurs, e.g., blood cholesterol and heart disease. We sought to discover metabolic …

A Systematic Review Of The Long-Term Clinical Success Of Gastric Peroral Endoscopic Myotomy For Refractory Gastroparesis, Tamara Stojilkovic, Kelsey Staudinger, Jennifer F. Dennis

Student Publications

Gastroparesis is a chronic and debilitating gastrointestinal disorder with few medical treatment options. Traditional surgical management has involved laparoscopic pyloromyotomy or gastric stimulation. In recent years, gastric peroral endoscopic myotomy (GPOEM) has become an attractive, less invasive option for patients with refractory gastroparesis. There is little information on the long-term clinical success of GPOEM in patients with refractory gastroparesis. This systematic review aims to evaluate the data on this procedure's long-term clinical efficacy and safety. A comprehensive literature review was done in PubMed, EMBASE, Ovid, and Google Scholar databases from the date of earliest entry in May 2017 up to …

Understanding Irrigation Water Optimization, Burdette Barker, Matt Yost, Jody Gale, Mark Nelson

All Current Publications

Irrigation is applied to much of the cropped area of Utah to support crop production. Limited water resources and competing demand for those resources make irrigation water conservation, irrigation water optimization, and efficient use of irrigation water important components of overall water resource management. It is well known in Utah that optimal irrigation use is even more critical during drought conditions. However, optimization practices change the quantity, quality, and timing of water flows. It is important to consider the possible hydrologic impact of irrigation practice changes and the desired outcome of an optimization practice to avoid implementing a practice that …

Transoptic Landscape Analysis: Multidimensional Landscapes Of A Multinational Wales, Mark Rhodes

Michigan Tech Publications, Part 1

In this article I propose a novel extension to landscape analysis through multidimensional understandings, including—yet reaching beyond—tangible and into more-than-representational understandings of landscape. This "transoptic" approach to landscape, breaking away from strictly searching for visual representations of culture, allows for sonic, experiential, and emotional layers of meaning embedded in landscapes to emerge from their plural cultural and historical contexts. Memory, and the production and experience of that memory in the landscape, benefit from this transoptic understanding. Utilizing memory work, which includes both memory production and consumption, in Wales as a case study, I employ a transoptic landscape analysis to approach …

Post-Harvest Eucalyptus Residue Removal Reduces Soil Aggregation And Biological Activities In Central-West Brazil, Karla Nascimento Sena, Thaís Soto Boni, Kátia Luciene Maltoni, Ana Maria Rodrigues Cassiolato, Engil Isadora Pujol Pereira

School of Earth, Environmental, & Marine Sciences Faculty Publications

Tree residue removal from Eucalyptus plantations after timber harvest can reduce soil functioning by reducing the organic matter input. To assess the effects of residue management systems (RMS) on soil aggregation, carbon (C) and nitrogen (N) content, and biological activities, a field trial was conducted in a commercial Eucalyptus plantation (loamy sand soil) in Mato Grosso do Sul, Brazil. The study assessed three RMS: cut-to-length (CTL), tree-length (TL), and bare litter (BL), respectively. After 21 months, undisturbed soil samples were collected and physically isolated into three aggregate-size fractions: large macroaggregates (LM), medium macroaggregates (SM), and microaggregates (MI). Results showed that …

Royal Assoc. Llc V. Gomez

All Decisions

No abstract provided.

Do Cognition And Emotion Matter? A Study Of Covid-19 Vaccination Decision-Making In College Students, Nien-Tsu Nancy Chen, Kimmy Kee, Bianca T. Villalobos, Miriam Ortiz, Hyesun Lee

Psychological Science Faculty Publications

The unparalleled speed of COVID-19 vaccine development has necessitated an expansion of existing knowledge on vaccination decision-making. The current study explored (1) how cognitions and emotions shaped college students’ COVID-19 vaccination decisions, and (2) where vaccination-inclined and vaccination-hesitant students converged and diverged in their decision-making process. Seventy-seven students participated in 26 focus groups to discuss their complex thoughts and feelings regarding COVID-19 vaccination, offering a more nuanced understanding of COVID-19 vaccination decision-making that has not been fully captured by quantitative studies. Thematic analysis found that vaccination-inclined participants and their hesitant counterparts reported differential patterns of positive and negative emotions, systematic …