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Recommending Answers To Math Questions Using Kl-Divergence And The Approximate Xml Tree Matching Approach, Siqi Gao May 2023

Recommending Answers To Math Questions Using Kl-Divergence And The Approximate Xml Tree Matching Approach, Siqi Gao

Theses and Dissertations

Mathematics is the science and study of quality, structure, space, and change. It seeks out patterns, formulates new conjectures, and establishes the truth by rigorous deduction from appropriately chosen axioms and definitions. The study of mathematics makes a person better at solving problems. It gives someone skills that (s)he can use across other subjects and apply in many different job roles. In the modern world, builders use mathematics every day to do their work, since construction workers add, subtract, divide, multiply, and work with fractions. It is obvious that mathematics is a major contributor to many areas of study. For …


20230530_Moving In And Revitalizing Our Special Collections, Laura J. Hall May 2023

20230530_Moving In And Revitalizing Our Special Collections, Laura J. Hall

HSLIC Blog Post

No abstract provided.


Collusive Prosecution, Ben A. Mcjunkin, J.J. Prescott May 2023

Collusive Prosecution, Ben A. Mcjunkin, J.J. Prescott

Law & Economics Working Papers

In this Article, we argue that increasingly harsh collateral consequences have surfaced an underappreciated and undertheorized dynamic of criminal plea bargaining. Collateral consequences that mostly or entirely benefit third parties (such as other communities or other states) create an interest asymmetry that prosecutors and defendants can exploit in plea negotiations. In particular, if a prosecutor and a defendant can control the offense of conviction (often through what some term a “fictional plea”), they can work together to evade otherwise applicable collateral consequences, such as deportation or sex-offender registration and notification. Both parties arguably benefit: Prosecutors can leverage collateral consequences to …


The Effects Of Dual Iqos And Cigarette Smoke Exposure On Airway Epithelial Cells: Implications For Lung Health And Respiratory Disease Pathogenesis, Pritam Saha, Siddhi Jain, Ipsita Mukherjee, Samir R. Panda, Amir A. Zeki, V.G.M. Naidu, Pawan Sharma May 2023

The Effects Of Dual Iqos And Cigarette Smoke Exposure On Airway Epithelial Cells: Implications For Lung Health And Respiratory Disease Pathogenesis, Pritam Saha, Siddhi Jain, Ipsita Mukherjee, Samir R. Panda, Amir A. Zeki, V.G.M. Naidu, Pawan Sharma

Center for Translational Medicine Faculty Papers

Background Cigarette smoking remains a primary cause of chronic lung diseases. After a steady decline, smoking rates have recently increased especially with the introduction of newer electronic nicotine delivery devices, and it is also emerging that dual- or poly-product usage is on the rise. Additionally, with the introduction of IQOS (a heated tobacco product) globally, its impact on human health needs to be investigated. In this study we tested if dual exposure (cigarette smoke (CS)+IQOS) is detrimental to lung epithelial cells when compared with CS or IQOS exposure alone.

Methods Human airway epithelial cells (BEAS-2B) were exposed to either CS, …


Enhanced Evasion Of Neutralizing Antibody Response By Omicron Xbb15, Ch11, And Ca31 Variants, Panke Qu, Julia N Faraone, John P Evans, Yi-Min Zheng, Claire Carlin, Mirela Anghelina, Patrick Stevens, Soledad Fernandez, Daniel Jones, Ashish R Panchal, Linda J Saif, Eugene M Oltz, Baoshan Zhang, Tongqing Zhou, Kai Xu, Richard J Gumina, Shan-Lu Liu May 2023

Enhanced Evasion Of Neutralizing Antibody Response By Omicron Xbb15, Ch11, And Ca31 Variants, Panke Qu, Julia N Faraone, John P Evans, Yi-Min Zheng, Claire Carlin, Mirela Anghelina, Patrick Stevens, Soledad Fernandez, Daniel Jones, Ashish R Panchal, Linda J Saif, Eugene M Oltz, Baoshan Zhang, Tongqing Zhou, Kai Xu, Richard J Gumina, Shan-Lu Liu

Faculty, Staff and Student Publications

Omicron subvariants continuingly challenge current vaccination strategies. Here, we demonstrate nearly complete escape of the XBB.1.5, CH.1.1, and CA.3.1 variants from neutralizing antibodies stimulated by three doses of mRNA vaccine or by BA.4/5 wave infection, but neutralization is rescued by a BA.5-containing bivalent booster. CH.1.1 and CA.3.1 show strong immune escape from monoclonal antibody S309. Additionally, XBB.1.5, CH.1.1, and CA.3.1 spike proteins exhibit increased fusogenicity and enhanced processing compared with BA.2. Homology modeling reveals the key roles of G252V and F486P in the neutralization resistance of XBB.1.5, with F486P also enhancing receptor binding. Further, K444T/M and L452R in CH.1.1 and …


Optimization Of The Filler-And-Binder Mixing Ratio For Enhanced Mechanical Strength Of Carbon-Carbon Composites, Ji-Hong Kim, Hye-In Hwang, Ji-Sun Im May 2023

Optimization Of The Filler-And-Binder Mixing Ratio For Enhanced Mechanical Strength Of Carbon-Carbon Composites, Ji-Hong Kim, Hye-In Hwang, Ji-Sun Im

Faculty, Staff and Student Publications

In this paper, a method for optimizing the mixing ratio of filler coke and binder for high-strength carbon-carbon composites is proposed. Particle size distribution, specific surface area, and true density were analyzed to characterize the filler properties. The optimum binder mixing ratio was experimentally determined based on the filler properties. As the filler particle size was decreased, a higher binder mixing ratio was required to enhance the mechanical strength of the composite. When the d


Microfibril-Associated Protein 5 And The Regulation Of Skin Scar Formation, Chen Han, Trevor R Leonardo, Bruna Romana-Souza, Junhe Shi, Shalyn Keiser, Heidi Yuan, Mohamad Altakriti, Matthew J Ranzer, Sammy Ferri-Borgogno, Samuel C Mok, Timothy J Koh, Seok Jong Hong, Lin Chen, Luisa A Dipietro May 2023

Microfibril-Associated Protein 5 And The Regulation Of Skin Scar Formation, Chen Han, Trevor R Leonardo, Bruna Romana-Souza, Junhe Shi, Shalyn Keiser, Heidi Yuan, Mohamad Altakriti, Matthew J Ranzer, Sammy Ferri-Borgogno, Samuel C Mok, Timothy J Koh, Seok Jong Hong, Lin Chen, Luisa A Dipietro

Faculty, Staff and Student Publications

Many factors regulate scar formation, which yields a modified extracellular matrix (ECM). Among ECM components, microfibril-associated proteins have been minimally explored in the context of skin wound repair. Microfibril-associated protein 5 (MFAP5), a small 25 kD serine and threonine rich microfibril-associated protein, influences microfibril function and modulates major extracellular signaling pathways. Though known to be associated with fibrosis and angiogenesis in certain pathologies, MFAP5's role in wound healing is unknown. Using a murine model of skin wound repair, we found that MFAP5 is significantly expressed during the proliferative and remodeling phases of healing. Analysis of existing single-cell RNA-sequencing data from …


Navigating Uncertainty: The Role Of Gold, Silver, Oil, Cryptocurrency, And Esg Indices In The Mena Region, Rahaf Zakaria Sakr May 2023

Navigating Uncertainty: The Role Of Gold, Silver, Oil, Cryptocurrency, And Esg Indices In The Mena Region, Rahaf Zakaria Sakr

Theses and Dissertations

This study examines the effectiveness of various financial instruments as hedges and safe havens during different market conditions in the MENA region. It compares traditional safe-haven investments ( gold, silver, and oil) and non-traditional safe-havens (cryptocurrencies and ESG stocks) to determine which investments function better as hedges and safe havens during different market conditions. The data covers eight years, starting in 2015 and ending in early 2023. DCC GARCH is utilized to examine time variation in conditional correlations. This study finds that Gold, Silver, and cryptocurrency can be considered strong hedges to the MENA market on average and weak safe …


England Logistics, Inc., England Carrier Services, Llc, And C.R England, Inc., Plaintiffs / Appellees V. Kelle's Transport Service, Llc, Tim Zack, Chris Nielsen, Casey Brown, Caleb Kuhn, Ryan Butler, Austin Butler, Joseph Charlton, Jim Quinn, Cody Isaacson, Raun Singleton, And Marc Kramer, Defendants / Appellants : Brief Of Appellant, Utah Court Of Appeals May 2023

England Logistics, Inc., England Carrier Services, Llc, And C.R England, Inc., Plaintiffs / Appellees V. Kelle's Transport Service, Llc, Tim Zack, Chris Nielsen, Casey Brown, Caleb Kuhn, Ryan Butler, Austin Butler, Joseph Charlton, Jim Quinn, Cody Isaacson, Raun Singleton, And Marc Kramer, Defendants / Appellants : Brief Of Appellant, Utah Court Of Appeals

Utah Court of Appeals Briefs (2020 –)

On appeal from the Third Judicial District Court, Salt Lake County, Honorable Mark Kouris, District Court No. 180909680

Jeffery S. Williams, NELSON CHRISTENSEN, Walter A. Romney, Jr., Justin R. Olsen, Attorneys for Appellees

Troy L. Booher, Caroline A. Olsen, Taylor P. Webb, Lincoln W. Hobbs, Attorney for Appellants


Julie Kinsey, Petitioner/Appellee V. Glen D. Kinsey, Respondent/Appellant : Brief Of Appellant, Utah Court Of Appeals May 2023

Julie Kinsey, Petitioner/Appellee V. Glen D. Kinsey, Respondent/Appellant : Brief Of Appellant, Utah Court Of Appeals

Utah Court of Appeals Briefs (2020 –)

On Appeal from the Third Judicial District Court, Salt Lake County, Utah, before the Honorable Judge Dianna Gibson, District Court Judge Case No. 20-4907035 DA

K. Bradley Carr (14428) CARR WOODALL Attorney for Respondent/Appellant Glen D. Kinsey

Cory R. Wall (4937) WALL & WALL, apc Attorney for Petitioner/Appellee Julie Kinsey


Amniotic Fluid Embolism Diagnosis & Treatment Pathway, Jeremy May May 2023

Amniotic Fluid Embolism Diagnosis & Treatment Pathway, Jeremy May

Doctor of Nursing Practice Projects

Access to care in rural areas can prove difficult for any patient, but especially for the expecting mother. Healthcare providers in these rural settings often lack the staffing and experience to effectively recognize and treat rare obstetric emergencies. Amniotic fluid embolism (AFE) is a rare medical emergency that requires healthcare providers to rapidly diagnose, monitor, and treat the sequela of resulting symptoms in the obstetric patient. After a literature review, a teaching session was developed and implemented as part of the annual training for 20 nursing staff at a small 50-bed rural hospital in central California. An 8-question pre-test was …


Search For Heavy Resonances And Quantum Black Holes In Eμ, Eτ, And Μτ Final States In Proton-Proton Collisions At √S = 13 Tev, A. Tumasyan May 2023

Search For Heavy Resonances And Quantum Black Holes In Eμ, Eτ, And Μτ Final States In Proton-Proton Collisions At √S = 13 Tev, A. Tumasyan

Department of Physics and Astronomy: Faculty Publications

A search is reported for heavy resonances and quantum black holes decaying into eμ, eτ, and μτ final states in proton-proton collision data recorded by the CMS experiment at the CERN LHC during 2016–2018 at √s = 13TeV, corresponding to an integrated luminosity of 138 fb−1. The eμ, eτ, and μτ invariant mass spectra are reconstructed, and no evidence is found for physics beyond the standard model. Upper limits are set at 95% confidence level on the product of the cross section and branching fraction for lepton flavor violating signals. Three benchmark signals are studied: resonant τ sneutrino …


Post-Processed Data And Graphical Tools For A Conus-Wide Eddy Flux Evapotranspiration Dataset, J. M. Volk, J. L. Huntington, F. Melton, B. Minor, T. Wang, S. Anapalli, R. G. Anderson, S. Evett, A. French, R. Jasoni, N. Bambach, W. P. Kustas, J. Alfieri, J. Prueger, L. Hipps, L. Mckee, S. J. Castro, M. M. Alsina, A. J. Mcelrone, M. Reba, B. Runkle, M. Saber, C. Sanchez, E. Tajfar, R. Allen, M. Anderson May 2023

Post-Processed Data And Graphical Tools For A Conus-Wide Eddy Flux Evapotranspiration Dataset, J. M. Volk, J. L. Huntington, F. Melton, B. Minor, T. Wang, S. Anapalli, R. G. Anderson, S. Evett, A. French, R. Jasoni, N. Bambach, W. P. Kustas, J. Alfieri, J. Prueger, L. Hipps, L. Mckee, S. J. Castro, M. M. Alsina, A. J. Mcelrone, M. Reba, B. Runkle, M. Saber, C. Sanchez, E. Tajfar, R. Allen, M. Anderson

Department of Agricultural and Biological Systems Engineering: Faculty Publications

Large sample datasets of in situ evapotranspiration (ET) measurements with well documented data provenance and quality assurance are critical for water management and many fields of earth science research. We present a post-processed ET oriented dataset at daily and monthly timesteps, from 161 stations, including 148 eddy covariance flux towers, that were chosen based on their data quality from nearly 350 stations across the contiguous United States. In addition to ET, the data includes energy and heat fluxes, meteorological measurements, and reference ET downloaded from grid- MET for each flux station. Data processing techniques were conducted in a reproducible manner …


Toxicological Effects Assessment For Wildlife In The 21st Century: Review Of Current Methods And Recommendations For A Path Forward, Thomas G. Bean, Val R. Beasley, Philippe Berny, Karen M. Eisenreich, John E. Elliott, Margaret L. Eng, Phyllis C. Fuchsman, Mark S. Johnson, Mason D. King, Rafael Mateo, Carolyn B. Meyer, Christopher J. Salice, Barnett A. Rattner May 2023

Toxicological Effects Assessment For Wildlife In The 21st Century: Review Of Current Methods And Recommendations For A Path Forward, Thomas G. Bean, Val R. Beasley, Philippe Berny, Karen M. Eisenreich, John E. Elliott, Margaret L. Eng, Phyllis C. Fuchsman, Mark S. Johnson, Mason D. King, Rafael Mateo, Carolyn B. Meyer, Christopher J. Salice, Barnett A. Rattner

United States Geological Survey: Staff Publications

Model species (e.g., granivorous gamebirds, waterfowl, passerines, domesticated rodents) have been used for decades in guideline laboratory tests to generate survival, growth, and reproductive data for prospective ecological risk assessments (ERAs) for birds and mammals, while officially adopted risk assessment schemes for amphibians and reptiles do not exist. There are recognized shortcomings of current in vivo methods as well as uncertainty around the extent to which species with different life histories (e.g., terrestrial amphibians, reptiles, bats) than these commonly used models are protected by existing ERA frameworks. Approaches other than validating additional animal models for testing are being developed, but …


Ndls Communicator: Week Of 05.30.22, Notre Dame Law School May 2023

Ndls Communicator: Week Of 05.30.22, Notre Dame Law School

NDLS Communicator

The Latest News

  • G. Marcus Cole reappointed as dean of Notre Dame Law School
  • Paolo Carozza receives ND faculty award
  • Becket Fund for Religious Liberty presents ND Law Dean G. Marcus Cole with 2023 Legal Service Award
  • ND Law to hold third annual Notre Dame Religious Liberty Summit in London
  • UK House of Lords member David Alton to receive 2023 Notre Dame Prize for Religious Liberty
  • Conference in Chile explores religious liberty and educational pluralism in Latin America and the Caribbean
  • Professor Marah Stith McLeod holds criminal law workshop at Notre Dame’s Kylemore Abbey
  • Program on Church, State & Society …


Show Your Wildcat Pride And Receive A Unh Hat, Jeremy Gasowski May 2023

Show Your Wildcat Pride And Receive A Unh Hat, Jeremy Gasowski

UNH Today Archive

No abstract provided.


Ten‐Year Cardiovascular Disease Risk Score And Cognitive Function Among Older Adults: The National Health And Nutrition Examination Survey 2011 To 2014, Jingkai Wei, Hanzhang Xu, Angela D. Liese, Anwar T. Nerchant Sc.D, Mph, Dmd, Liang Wang, Chih-Hsiang Yang, Matthew C. Lohman, Monique J. Brown Ph.D., Mph, Tiansheng Wang, Daniela B. Friedman Ph.D. May 2023

Ten‐Year Cardiovascular Disease Risk Score And Cognitive Function Among Older Adults: The National Health And Nutrition Examination Survey 2011 To 2014, Jingkai Wei, Hanzhang Xu, Angela D. Liese, Anwar T. Nerchant Sc.D, Mph, Dmd, Liang Wang, Chih-Hsiang Yang, Matthew C. Lohman, Monique J. Brown Ph.D., Mph, Tiansheng Wang, Daniela B. Friedman Ph.D.

Faculty Publications

BACKGROUND: The Framingham 10-year cardiovascular disease risk score, which is based on age, sex, smoking, total cholesterol, high-density lipoprotein-cholesterol, blood pressure, and diabetes, has been found to be associated with cognitive health, but these findings have not been validated in a representative sample in the United States. We aimed to examine the associations of Framingham risk score with cognitive function among older adults in a nationally representative sample, as well as by race or ethnicity, education, and family income.

METHODS AND RESULTS: A total of 2254 older adults ≥60years (57% female, 79% non-Hispanic White) in the National Health and Nutrition …


Patterns Of Hiv Disclosure And Its Impact On The Hiv Care Continuum Among Black Men Who Have Sex With Men In South Carolina, Xueying Yang Ph.D., Titilayo A. James, Monique J. Brown Ph.D., Mph, Tony Brown, Sydney Zarsadias, Ran Zhang, Fanghui Shi, Xiaoming Li Ph.D. May 2023

Patterns Of Hiv Disclosure And Its Impact On The Hiv Care Continuum Among Black Men Who Have Sex With Men In South Carolina, Xueying Yang Ph.D., Titilayo A. James, Monique J. Brown Ph.D., Mph, Tony Brown, Sydney Zarsadias, Ran Zhang, Fanghui Shi, Xiaoming Li Ph.D.

Faculty Publications

Addressing the psychosocial concerns of Black men who have sex with men (MSM), such as HIV disclosure, is critical for effective HIV treatment efforts. Black MSM living with HIV experience multiple psychosocial challenges, such as “triple stigma” due to their sexual orientation, racial minority status, and HIV status, which hinder their HIV disclosure and subsequent HIV care-seeking behavior. Our study sought to examine the HIV disclosure patterns and their impact on the HIV care continuum among Black MSM using a qualitative approach. Semi-structured interviews were carried out among 28 Black MSM aged ≥18 years old living in South Carolina. A …


Digital Competitiveness And Poverty Index Quadrant: Mapping The Digital Public Administration Challenge (Evidence From Indonesia), Rutiana D. Wahyunengseh, Sri Hastjarjo May 2023

Digital Competitiveness And Poverty Index Quadrant: Mapping The Digital Public Administration Challenge (Evidence From Indonesia), Rutiana D. Wahyunengseh, Sri Hastjarjo

BISNIS & BIROKRASI: Jurnal Ilmu Administrasi dan Organisasi

The role of the internet in reducing poverty has been tested in several countries. However, according to bibliometric analysis, not much has been studied from the perspective of inclusive digital public administration. This research's novelty is to complements the digital governance research by analyzing the relationship between digital competitiveness and poverty rates in Indonesia. This study aims to map the challenges of developing digital governance in Indonesia in the context of promoting sustainable development and more inclusive society. The research method uses descriptive quantitative with quadrant analysis techniques. The data used are the poverty rate from the Indonesian Central Bureau …


A Comparative Study On Contract-Based And Coproduction-Based Entrepreneurship Training Programs: A Study Case Of Jakarta Province, Fazlur Rahman Hassan, Muhammad Rizqy Anandhika, Maulana Fajrul Izzi May 2023

A Comparative Study On Contract-Based And Coproduction-Based Entrepreneurship Training Programs: A Study Case Of Jakarta Province, Fazlur Rahman Hassan, Muhammad Rizqy Anandhika, Maulana Fajrul Izzi

BISNIS & BIROKRASI: Jurnal Ilmu Administrasi dan Organisasi

Training is essential to guide and equip SMEs with the necessary skill sets to adapt to the disruption of the COVID-19 pandemic. The budget limitation urged DKI Jakarta Provincial Government (DJPG) to change their conventional training program for SMEs and arrange an IT-based platform enabling all city entities, including private and non-private sectors, to participate in a coproduction scheme. This study employed the performance outcomes framework to examine the impacts of coproduction in entrepreneurship training for SMEs by comparing contract-based and coproduction-based training conducted by DJPG, including the impacts on the deliverables and budget. The results indicate that overall, coproduction-based …


On The Power Of Attainable Architecture Community Engagement And Interaction Through Architecture: A New Approach To Architectural Exhibitions, Jianing Yang May 2023

On The Power Of Attainable Architecture Community Engagement And Interaction Through Architecture: A New Approach To Architectural Exhibitions, Jianing Yang

Masters Theses

This thesis explores the potential of architecture exhibitions as a medium to make architecture more accessible and relevant to the public. Drawing inspiration from an article titled "6 Small Scale Projects with Large Social Impact", it highlights the significance of small-scale architectural interventions that foster social responsibility, public engagement, and sustainability.

The prevalent architectural elitism often overlooks attainable, small-scale architecture, which advocates for a broader appreciation of architecture, including the everyday built environments that shape our communities and everyday lives.

The thesis proposes a new approach to architecture exhibitions emphasizing authentic immersion and engagement. It introduces a unique 1:1 experience …


Executive Committee - Agenda 5/30/2023, Academic Senate May 2023

Executive Committee - Agenda 5/30/2023, Academic Senate

Academic Senate Agendas

No abstract provided.


Male Nursing Students In The Community College And The Struggle To Completion, Geri Brewer May 2023

Male Nursing Students In The Community College And The Struggle To Completion, Geri Brewer

Dissertations

Despite significant contributions to healthcare made by male nurses throughout the centuries, nursing is a female-dominated profession, creating challenges for male nursing students. The problem addressed in this study was that male nursing students experience challenges that impede their success toward completing their urban Midwest community college nursing program. Guided by the nursing undergraduate retention and success model, the purpose of this basic qualitative study was to explore male nursing students' perceptions of the challenges they face that impede their success and their recommendations for the supports they need to overcome these challenges within two urban Midwest community college nursing …


The Impact Of Leadership Behavior On Employee Engagement: A Qualitative Study, Torie M. Bonnet May 2023

The Impact Of Leadership Behavior On Employee Engagement: A Qualitative Study, Torie M. Bonnet

Theses

Employee engagement has been shown by previous researchers to improve the quality of work that is produced. Previous researchers have focused on how various leadership styles impact engagement. Researchers have revealed that the concepts of structural empowerment, authentic leadership, transformational leadership, and leader-empowering behavior have positively impacted employees' levels of engagement. The knowledge gap includes what behaviors lead to improved employee engagement, resulting in an upbeat team climate and decreased intention to leave a position. This study was designed to glean knowledge from experienced nurse managers regarding employee engagement and understand what skills could be taught to novice managers to …


Elizabeth Fitt, Oral History Interview, 2023, You Li May 2023

Elizabeth Fitt, Oral History Interview, 2023, You Li

Collective Memory of Women Journalists in COVID-19

Elizabeth Fitt is a freelance photographer based out of Beirut, Lebanon. Her work has been published with various media outlets including the Guardian, the Sunday Times, Forbes, Foreign Policy, the Telegraph, CNN, ABC Australia, The National, Middle East Eye, The New Humanitarian, The New York Post, and the New Scientist. She also writes on environmental issues for Mongabay.

In this interview, Fitt recalled the ground situation in Lebanon and the extreme caution and effort it took her to photograph vulnerable communities during lockdowns. Her projects depicted the overwhelming and devastating scenes in the ICU Wards, the food distribution among the …


Kathy Gannon, Oral History Interview, 2023, You Li May 2023

Kathy Gannon, Oral History Interview, 2023, You Li

Collective Memory of Women Journalists in COVID-19

Kathy Gannon covered Afghanistan and Pakistan for the Associated Press as chief correspondent and later news director for 35 years. She also covered the 2006 war in South Lebanon, the Iraq War, the Central Asian States, and the Middle East. Gannon was the only Western journalist allowed in Kabul by the Taliban in the weeks preceding the 2001 U.S.-British offensive in Afghanistan. In April 2014 Gannon was seriously wounded, hit by seven bullets while covering preparations for Afghan national elections when an Afghan police officer opened fire on the car in which she was riding. A Canadian native, she received …


Copus Profiles Paper Data, Jamie Jensen, Rebecca L. Sansom, Jennifer B. Nielson, Richard E. West, Geoffrey Wright, Bryn St. Clair May 2023

Copus Profiles Paper Data, Jamie Jensen, Rebecca L. Sansom, Jennifer B. Nielson, Richard E. West, Geoffrey Wright, Bryn St. Clair

ScholarsArchive Data

COPUS profile data, interview transcripts


Whole-Genome Sequencing Analysis Of Human Metabolome In Multi-Ethnic Populations, Elena V Feofanova, Michael R Brown, Taryn Alkis, Astrid M Manuel, Xihao Li, Usman A Tahir, Zilin Li, Kevin M Mendez, Rachel S Kelly, Qibin Qi, Han Chen, Martin G Larson, Rozenn N Lemaitre, Alanna C Morrison, Charles Grieser, Kari E Wong, Robert E Gerszten, Zhongming Zhao, Jessica Lasky-Su, Bing Yu May 2023

Whole-Genome Sequencing Analysis Of Human Metabolome In Multi-Ethnic Populations, Elena V Feofanova, Michael R Brown, Taryn Alkis, Astrid M Manuel, Xihao Li, Usman A Tahir, Zilin Li, Kevin M Mendez, Rachel S Kelly, Qibin Qi, Han Chen, Martin G Larson, Rozenn N Lemaitre, Alanna C Morrison, Charles Grieser, Kari E Wong, Robert E Gerszten, Zhongming Zhao, Jessica Lasky-Su, Bing Yu

Faculty, Staff and Student Publications

Circulating metabolite levels may reflect the state of the human organism in health and disease, however, the genetic architecture of metabolites is not fully understood. We have performed a whole-genome sequencing association analysis of both common and rare variants in up to 11,840 multi-ethnic participants from five studies with up to 1666 circulating metabolites. We have discovered 1985 novel variant-metabolite associations, and validated 761 locus-metabolite associations reported previously. Seventy-nine novel variant-metabolite associations have been replicated, including three genetic loci located on the X chromosome that have demonstrated its involvement in metabolic regulation. Gene-based analysis have provided further support for seven …


Towards Generalizable Machine Learning Models For Computer-Aided Diagnosis In Medicine, Yiyang Wang May 2023

Towards Generalizable Machine Learning Models For Computer-Aided Diagnosis In Medicine, Yiyang Wang

College of Computing and Digital Media Dissertations

Hidden stratification represents a phenomenon in which a training dataset contains unlabeled (hidden) subsets of cases that may affect machine learning model performance. Machine learning models that ignore the hidden stratification phenomenon--despite promising overall performance measured as accuracy and sensitivity--often fail at predicting the low prevalence cases, but those cases remain important. In the medical domain, patients with diseases are often less common than healthy patients, and a misdiagnosis of a patient with a disease can have significant clinical impacts. Therefore, to build a robust and trustworthy CAD system and a reliable treatment effect prediction model, we cannot only pursue …


Criminal Justice Reform And The Centrality Of Intent, Cynthia V. Ward May 2023

Criminal Justice Reform And The Centrality Of Intent, Cynthia V. Ward

Villanova Law Review (1956 - )

No abstract provided.