Digital Commons Network^™

Commentary: Myocardial Relaxation Matters, Paige E Brlecic, Todd K Rosengart

Faculty, Staff and Students Publications

No abstract provided.

Pediatric Ercp In The Setting Of Acute Pancreatitis: A Secondary Analysis Of An International Multicenter Cohort Study, Carolena Trocchia, Racha Khalaf, Ernest Amankwah, Wenly Ruan, Douglas S Fishman, Bradley A Barth, Quin Y Liu, Matthew Giefer, Kyung Mo Kim, Mercedes Martinez, Luigi Dall'oglio, Filippo Torroni, Paola De Angelis, Simona Faraci, Sam Bitton, Steven L Werlin, Kulwinder Dua, Roberto Gugig, Clifton Huang, Petar Mamula, J Antonio Quiros, Yuhua Zheng, Travis Piester, Amit Grover, Victor L Fox, Michael Wilsey, David M Troendle

Faculty, Staff and Students Publications

Previous studies have demonstrated the safety of performing endoscopic retrograde cholangiopancreatography (ERCP) in the pediatric population; however, few have addressed the outcomes of children undergoing ERCP during acute pancreatitis (AP). We hypothesize that ERCP performed in the setting of AP can be executed with similar technical success and adverse event profiles to those in pediatric patients without pancreatitis. Using the Pediatric ERCP Database Initiative, a multi-national and multi-institutional prospectively collected dataset, we analyzed 1124 ERCPs. One hundred and ninety-four (17%) of these procedures were performed in the setting of AP. There were no difference in the procedure success rate, procedure …

Association Between Modifiable Social Determinants And Mental Health Among Post-9/11 Veterans: A Systematic Review, Nipa Kamdar, Sundas Khan, Diana P Brostow, Lia Spencer, Sharmily Roy, Amy Sisson, Natalie E Hundt

Faculty, Staff and Students Publications

Introduction: As U.S. Veterans reintegrate from active duty to civilian life, many are at risk for negative modifiable social determinants of health. The prevalence of mental health conditions among Veterans is also high. Awareness of the associations between these two factors is growing. This systematic review provides a comprehensive analysis of the current state of knowledge of the associations between modifiable social determinants and mental health among U.S. Veterans.

Methods: The authors systematically searched four databases and identified 28 articles representing 25 unique studies that met inclusion criteria. Findings from the studies were extracted and synthesized on the basis of …

Interstitial Nephritis: Wherefrom, Wherein, And Whereto, Garabed Eknoyan

Faculty, Staff and Students Publications

Abnormalities of the renal interstitium were noted early while identifying chronic kidney disease in 1827; however, interest in glomerular and vascular lesions was then distracted from their further study. As a complication of scarlet fever, interstitial lesions attracted attention in 1859 and came to be defined as acute interstitial nephritis in 1898. The chronic form of interstitial nephritis was traditionally attributed to pyelonephritis until the advent of kidney biopsy in the 1950s, when interstitial lesions were recognized as an independent primary cause of chronic kidney disease from studies of analgesic nephropathy and vesico-ureteral reflux. The term tubulointerstitial nephritis was introduced …

The Nanoflow Repository, Jessie E Arce, Joshua A Welsh, Sean Cook, John Tigges, Ionita Ghiran, Jennifer C Jones, Andrew Jackson, Matthew Roth, Aleksandar Milosavljevic

Faculty, Staff and Students Publications

Motivation

Extracellular particles (EPs) are the focus of a rapidly growing area of exploration due to the widespread interest in understanding their roles in health and disease. However, despite the general need for EP data sharing and established community standards for data reporting, no standard repository for EP flow cytometry data captures rigor and minimum reporting standards such as those defined by MIFlowCyt-EV (https://doi.org/10.1080/20013078.2020.1713526). We sought to address this unmet need by developing the NanoFlow Repository.

Results

We have developed The NanoFlow Repository to provide the first implementation of the MIFlowCyt-EV framework.

Availability and implementation

The NanoFlow Repository …

Evaluating Demographic Representation In Clinical Trials: Use Of The Adaptive Coronavirus Disease 2019 Treatment Trial (Actt) As A Test Case, Ana M Ortega-Villa, Noreen A Hynes, Corri B Levine, Katherine Yang, Zanthia Wiley, Nikolaus Jilg, Jing Wang, Jennifer A Whitaker, Christopher J Colombo, Seema U Nayak, Hannah Jang Kim, Nicole M Iovine, Dilek Ince, Stuart H Cohen, Adam J Langer, Jonathan M Wortham, Robert L Atmar, Hana M El Sahly, Mamta K Jain, Aneesh K Mehta, Cameron R Wolfe, Carlos A Gomez, Tatiana Beresnev, Richard A Mularski, Catharine I Paules, Andre C Kalil, Angela R Branche, Annie Luetkemeyer, Barry S Zingman, Jocelyn Voell, Michael Whitaker, Michelle S Harkins, Richard T Davey, Robert Grossberg, Sarah L George, Victor Tapson, William R Short, Varduhi Ghazaryan, Constance A Benson, Lori E Dodd, Daniel A Sweeney, Kay M Tomashek

Faculty, Staff and Students Publications

Background: Clinical trials initiated during emerging infectious disease outbreaks must quickly enroll participants to identify treatments to reduce morbidity and mortality. This may be at odds with enrolling a representative study population, especially when the population affected is undefined.

Methods: We evaluated the utility of the Centers for Disease Control and Prevention's COVID-19-Associated Hospitalization Surveillance Network (COVID-NET), the COVID-19 Case Surveillance System (CCSS), and 2020 United States (US) Census data to determine demographic representation in the 4 stages of the Adaptive COVID-19 Treatment Trial (ACTT). We compared the cumulative proportion of participants by sex, race, ethnicity, and age enrolled at …

The Early Impact Of Covid-19 On Intensive Care Nurses’ Personal And Professional Well-Being: A Qualitative Study, Kelly Calkins, Jill L. Guttormson, Natalie S. Mcandrew, Holly Losurdo, Danielle Loonsfoot, Shania Schmitz, Jacklynn M. Fitzgerald

College of Nursing Faculty Research and Publications

Objective

To describe the impact of the COVID-19 pandemic on intensive care nurses personal and professional well-being.

Research Methodology/Design

A descriptive, qualitative design was used. Two nurse researchers conducted one-on-one interviews via Zoom or TEAMS using a semi-structured interview guide.

Setting

Thirteen nurses who were working in an intensive care unit in the United States participated in the study. A convenience sample of nurses who completed a survey in the larger parent study provided an email and were contacted by the research team to participate in interviews to discuss their experiences.

Main Outcome Measures

An inductive approach to content analysis …

Snowmobile Recreation In Western Montana, Liam Harry, Melissa Weddell

Institute for Tourism and Recreation Research Publications

This report is a summary of recreation snowmobilers in Western Montana regarding their visitor characteristics and demographics. The Institute forTourism and Recreation Research (ITRR) conducted surveys of snowmobilers to understand the profile and general characteristics of this user group.

Influence Of Depression And Interpersonal Support On Adherence To Antiretroviral Therapy Among People Living With Hiv, Jerry John Nutor, Akua O. Gyamerah, Robert Kaba Alhassan, Henry Ofori Duah, Rachel G.A. Thompson, Natalie Wilson, Orlando Harris, Jose Gutierrez, Thomas J. Hoffmann, Monica Getahun, Glenn-Milo Santos

College of Nursing Faculty Research and Publications

Background

Poor adherence and under-utilization of antiretroviral therapy (ART) services have been major setbacks to achieving 95-95-95 policy goals in Sub-Saharan Africa. Social support and mental health challenges may serve as barriers to accessing and adhering to ART but are under-studied in low-income countries. The purpose of this study was to examine the association of interpersonal support and depression scores with adherence to ART among persons living with HIV (PLWH) in the Volta region of Ghana.

Methods

We conducted a cross-sectional survey among 181 PLWH 18 years or older who receive care at an ART clinic between November 2021 and …

Carboplasty, A Minimally Invasive Procedure For Knee Osteoarthritis: Surgical Technique And Clinical Evidence, Antonio Madrazo-Ibarra, David A. Kolin, Tracey Hunter, Joseph A. Ogyaadu, Henry Ofori Duah, Henry O. Tutu, Anthony Bandoh, Prudence Nutsuklo, Kwadwo Boachie-Adjei, Kaitlin M. Carroll, Amoli Vad, Eric Zhao, Vijay B. Vad

College of Nursing Faculty Research and Publications

Knee osteoarthritis affects ~16% of adults in the world and is considered one of the most incapacitating diseases. Despite the advances in scientific knowledge and biological treatments in the field of orthopedics, available nonsurgical treatments for knee osteoarthritis are limited and still ineffective in delaying or stopping the progression of arthritis. Biologics such as platelet-rich plasma, bone marrow aspirate, and progenitor cells have emerged as potential treatments for osteoarthritis; however, the results are still not as expected. Carboplasty is a new treatment that involves the application of bone marrow aspirate into the bone-cartilage interface and intra-articularly, with the intention of …

Exome-Wide Assessment Of Isolated Biliary Atresia: A Report From The National Birth Defects Prevention Study Using Child-Parent Trios And A Case-Control Design To Identify Novel Rare Variants, Pagna Sok, Aniko Sabo, Lynn M Almli, Mary M Jenkins, Wendy N Nembhard, A J Agopian, Michael J Bamshad, Elizabeth E Blue, Lawrence C Brody, Austin L Brown, Marilyn L Browne, Mark A Canfield, Suzan L Carmichael, Jessica X Chong, Shannon Dugan-Perez, Marcia L Feldkamp, Richard H Finnell, Richard A Gibbs, Denise M Kay, Yunping Lei, Qingchang Meng, Cynthia A Moore, James C Mullikin, Donna Muzny, Andrew F Olshan, Faith Pangilinan, Jennita Reefhuis, Paul A Romitti, Jeremy M Schraw, Gary M Shaw, Martha M Werler, Sanjiv Harpavat, Philip J Lupo, University Of Washington Center For Mendelian Genomics, Nisc Comparative Sequencing Program, The National Birth Defects Prevention Study

Faculty, Staff and Students Publications

The etiology of biliary atresia (BA) is unknown, but recent studies suggest a role for rare protein-altering variants (PAVs). Exome sequencing data from the National Birth Defects Prevention Study on 54 child-parent trios, one child-mother duo, and 1513 parents of children with other birth defects were analyzed. Most (91%) cases were isolated BA. We performed (1) a trio-based analysis to identify rare de novo, homozygous, and compound heterozygous PAVs and (2) a case-control analysis using a sequence kernel-based association test to identify genes enriched with rare PAVs. While we replicated previous findings on PKD1L1, our results do not suggest that …

Uprooting Patriarchy: Meditations On Gender, Masculinities, And Healing Through Buddhist Practices, Noah Souder-Russo

Dissertations, Theses, and Capstone Projects

Western patriarchal socialization trains men and male-conditioned people to express dominance and power-over self and other. The particularly vicious expression of cis-hetero-white-patriarchal masculinity is a delusional force that continues to uphold all systems of domination, subjugating marginalized bodies and the earth herself. For those of us who have bought in to what bell hooks calls the “patriarchal ideal,” there is much work to be done to heal from the momentum of our conditioning for the well-being and sustainability of the collective. With an awareness of the untenable nature of perpetuating patriarchal dominance, efforts to unpack and uproot this internalization have …

A Gift To My Self: A Psychoanalytic Approach To Understanding The Experiences Of Women Who Choose Not To Have Children, Irina D. Tchania

Dissertations, Theses, and Capstone Projects

Although motherhood has long been a normative female experience, individual decisions regarding bearing and mothering children vary among women. Partly due to shifts in gender roles and contemporary societal expectations, the conflation of womanhood with motherhood – and the centrality of motherhood within female identity – is being increasingly challenged. Women who choose to remain childless make up a growing, unique, and understudied population group. Decisions regarding intentional childlessness have been considered through the lenses of sociology and feminist critique, while psychologically and psychoanalytically oriented scholarship is more limited. This study aimed to further our understanding of the voluntarily childless …

Babel, Daniel Horowitz

Dissertations, Theses, and Capstone Projects

This thesis is a series of three memoiristic essays around the vortex of identity. The first is an exploration of how childhood overmedication split the continuity of the author’s self-conception. The second traces the slipperiness of Jewish and Queer identifications detailing their synthesis in the klezmer revival in New York City in late 1980s and early 90s. The third is a polyphonic narration of the recovery of a lost klezmer’s life story in the face of the silence of time and slaughter.

Older Adults In The Great Recession: Labor Force Transitions, Perceived Workplace Ageism And Life Satisfaction, Duygu Başaran Şahin

Dissertations, Theses, and Capstone Projects

Until the global economic crisis caused by the Covid19 pandemic, the Great Recession (GR) of 2007-2009 was the most severe economic downturn since the Great Depression in the U.S. History. Previous research argues that older adults were relatively protected from the GR’s harshest impact because their unemployment rates were relatively lower compared to younger adults. However, the focus on unemployment rate as the ultimate indicator of a recession’s impact might have downplayed older adults’ experiences. Indeed, some studies showed that despite relatively lower unemployment rates, once unemployed, older adults took significantly longer to be reemployed compared to adults in younger …

Fantasmas Compartidos: Posmemoria, Herencia Y Reescritura De La Guerra Civil Española En México Y España, Mayte Lopez Sanchez

Dissertations, Theses, and Capstone Projects

This dissertation analyzes contemporary novels and films about the traumatic legacies of the Spanish Civil War through the lens of postmemory, memory studies, and transatlantic studies. I examine how Mexican and Spanish writers and filmmakers from the postwar generations approach the memories of their ancestors—and their own—to reframe history through fiction, memory work, and personal agency. Studies about historical memory are typically constrained to national contexts, but I highlight how trauma transcends the nation not only in space but also in time. Moreover, I focus on how inherited memories acquire new meanings in contemporary representations and how those resignifications have …

Evidence-Based Practice In The Management Of Tinnitus In Children And Adolescents: A Systematic Review Of The Literature, Rivka Deutsch

Dissertations, Theses, and Capstone Projects

Objective: The purpose of this investigation is to conduct a systematic review of the literature to compile and evaluate the known research on the management of tinnitus in children/ The specific aims of this paper are to determine what approaches can be considered best practice for the management of tinnitus in this population, what aspects of adult management (if any) can be adapted for children, and whether the literature supports one management approach over another.

Methods and Results: A comprehensive search utilizing the Medline and Cumulated Index to Nursing and Allied Health Literature (CINAHL), and Google Scholar databases, accessible via …

An Offer You Cannot Refuse: Understanding The Elusive Construct Of "Voluntary" Plea Decisions, Melanie B. Fessinger

Dissertations, Theses, and Capstone Projects

Defendants often plead guilty in exchange for reduced punishments. Some argue that these reduced punishments are necessary for the functioning of the criminal justice system, whereas others argue that they are inherently coercive because they place a burden on the exercise of constitutional rights. This potential coercion is of concern because the constitution requires valid guilty pleas to be made by defendants voluntarily. However, “voluntary” is an elusive construct of which courts, scholars, and laypeople have differing definitions. Although limited research has focused specifically on perceptions of voluntary pleas, decades of research have shown that individuals generally perceive decisions more …

Examining The Role Of Evidence-Based Suspicion In Racial Disparities In Wrongful Convictions, Jacqueline Katzman

Dissertations, Theses, and Capstone Projects

There are clear racial disparities in the rates of wrongful convictions, with Black exonerees disproportionately represented among the population of those exonerated, in DNA and non-DNA exonerations alike (National Registry of Exonerations, 2022; Innocence Project, 2022). This racial disparity also exists for those exonerees who were wrongfully convicted, at least in part, because an eyewitness mistakenly identified them. For decades, when eyewitness scholars explored racial bias, they focused on the cross-race effect or own-race bias among eyewitnesses, a bias positing that witness performance suffers when a witness is asked to make an identification of a cross-race face (Lee & Penrod, …

Numbered, Weighed, Divided: Revolution And/As Apocalypse In The Modern Liberal Tradition, Asher J. Wycoff

Dissertations, Theses, and Capstone Projects

A long-standing political-theological critique contends that liberalism lacks the capacity to address theological challenges, and qualitative political challenges more generally. This charge is prevalent in our current age of crises, when the capacity to address such challenges is essential to any political tradition’s self-legitimation. I argue that the liberal tradition, broadly conceived, has long contended with theological challenges, particularly during modern revolutionary periods. Theological discourses, especially eschatological ones, circulate widely in these moments. Modern political actors impute cosmic significance to the events of their present, with a central analogy crystallizing between revolution and apocalypse. Reading major theorists of three modern …

The Gilded Tropics: Winslow Homer And John Singer Sargent In Florida, 1886-1917, Theodore W. Barrow

Dissertations, Theses, and Capstone Projects

This dissertation examines the Floridian works of Winslow Homer and John Singer Sargent in the context of tourism, race, and the environment as perceptions of the tropics in an Anglo-American context. Both artists sojourned in Florida and produced a number of watercolors and related oils that not only testify to a rapidly-expanding tourist industry to the Sunshine State, but also update the Romantic myths of the tropics with a more sober, ironic Realist take. While Homer and Sargent continue to be popular subjects for studies and exhibitions on their own, this dissertation is the first to consider how their shared …

When Feeling Like A Fake Take A Toll On Your Work: Examining The Moderating Effect Of Task Characteristics On The Relationship Between Impostorism And The Use Of Dysfunctional Work Strategies, Alexandra Tumminia

Dissertations, Theses, and Capstone Projects

Impostor phenomenon refers to an experience of hidden feelings of intellectual fraudulence held in achievement domains. While research on the subject is limited, impostors are reasoned to use dysfunctional performance strategies marked by overworking and withdrawing (Clance & Imes, 1988). In the present studies, the relationship between impostorism and the use of overworking strategies (i.e., overpreparation, unnecessary rework) and withdrawing strategies (i.e., procrastination, self-handicapping) were explored among a sample of college students with work experience. These studies were designed to test whether task characteristics including autonomy (Study 1; N = 128) and the anticipation of feedback (Study 2; N = …

Algorithmic Sovereignty: Machine Learning, Ground Truth, And The State Of Exception, Matthew Martin

Dissertations, Theses, and Capstone Projects

This thesis examines the influence of algorithmic security technology on political theories of sovereignty and the state of exception. In computer science, an exception is a special circumstance that prevents a program from terminating normally. In political theory, the state of exception, as theorized by Carl Schmitt and Giorgio Agamben, cannot be encoded within the normal liberal legal order. With states’ increasing turn toward algorithmic answers to questions of ‘security,’ which, per Agamben, is the long-term form of the political state of exception, the relationship between the concept of the exception in these two disciplines comes to the fore. In …

Who Are Our Teachers? The Impact Of The Composition Teaching Practicum On Writing Studies, Maxine Krenzel

Dissertations, Theses, and Capstone Projects

For first year writing instructors, the teaching practicum is vital for navigating both the writing classroom and the institutions in which the classroom is embedded. The composition teaching practicum, or the often-required training course for new writing instructors, is where new instructors are typically first introduced to their institutional and departmental policies as well as to the field of Writing Studies. While the practicum is a course that is immensely important for new instructors, I have found that this course is nevertheless understudied, under- historicized, and—in institutional and disciplinary rhetoric—too often aligned with an abstract set of “best practices” that …

Disclosure Harmonization And R&D Investment Efficiency, Lu Tong

Dissertations, Theses, and Capstone Projects

This study examines the effect of harmonized patent disclosure on the efficiency of firms’ research and development (R&D) investment. Patent disclosure harmonization reduces uncertainty about patent validity and the costs of processing patent information, resulting in better R&D investment decisions than before. Leveraging the introduction of the Global Dossier portal, an initiative to harmonize patent disclosure across multiple jurisdictions, as a natural experiment, this study finds consistent evidence. Results also show that firms reporting in non-English languages benefit more than those reporting in English due to reduced processing costs. Further analysis reveals that the Global Dossier leads to an increased …

Stokes Vector Modulation Of Optical Signals; Coherence, Noise, And Digital Signal Processing, Mario Bnyamin

Dissertations, Theses, and Capstone Projects

Stokes vector modulation (SVM) is a method of encoding information onto an optical wave by controlling its amplitude and its state of polarization (SOP). SVM offers the potential to achieve the high spectral efficiency of multi-dimensional symbols using a power-efficient, direct-detection receiver. Combining the two independent degrees of freedom representing polarization with one representing amplitude, SVM symbols are defined in a 3-D space of Stokes vectors, where vector length represents the amplitude and altitude/azimuth angles represent the SOP. The recoverable information content is fundamentally limited by the noise on the received signal, which may include shot noise due to photon-counting, …

Transnational Ritual Poetics Of Blackness In Performance, Nina A. Mercer

Dissertations, Theses, and Capstone Projects

In this dissertation, I investigate transnational ritual poetics of Blackness through a historical, cultural, and spatial lens, centering my exploration on the recurrence of circles, the crossroads, and waterways. I show how these formal poetics activate Africana cosmologies, cosmogonies, and mythologies dramaturgically by centering contemporary New York City performance works that bring together dance, theatre, and music. I contextualize NYC performance case studies in relation to performance practices in contemporary Salvador da Bahia. I am particularly interested in how the recurrence of circles, the crossroads, and water as formal poetics catalyze interventions along contested water-ways and landscapes marked by Black …

Navigating Through World’S Military Spending Data With Scroll-Event Driven Visualization, Hong Beom Hur

Dissertations, Theses, and Capstone Projects

Catching up with the current geopolitical event is more important than ever these days. Anti-western nations like Russia, China, Iran, and North Korea constantly challenge the world order set by the United States and its close allies. As a result, the world has seen a rise in military spending consecutively for the last several years. This data visualization project aims to provide an easy-to-read summary of military spending data published by the Stockholm International Peace Research Institute for hotly conflicted regions: East Asia, Europe, and the Middle East.

Scroll-event-driven visualization implemented using Scrollama.js and D3.js combines text, map, and data …

Voiding The Unwanted Self: An Examination Of Racialized Violence In The United States, Benjamin Stark

Dissertations, Theses, and Capstone Projects

This dissertation is concerned with the role of the psychic defenses projection and projective identification in the processes which lead to racialized violence in the United States. The dissertation posits that projection has been less considered as a primary driver of racialized violence than other psychic processes and should be better integrated into psychological research and literature on racialized violence. The thesis begins with a detailed examination of two instances of racialized violence, the first a macro example of nation vs. nation: the United States’ invasion of Iraq in 2003, before which the United States fantasized Iraq was developing weapons …

Ethnic Tensions In The Western Balkans And The Experience Of Ethnic Minorities, Nadina Resulani

Dissertations, Theses, and Capstone Projects

The Western Balkan has experienced a past of ethnic turmoil. From the wars in Croatia, Bosnia and Herzegovina and Kosovo to ethnic tensions in Serbia, Montenegro, and North Macedonia. Understanding that ethnicity itself continues to be a salient factor in Western Balkan, the question remains how Western Balkan states were able to remove themselves from the front light of ethnic tensions considering today these countries are known as being tourist destinations, cultural and academic meccas, and democratic candidates in line to join the European Union. In reviewing and comparing the geopolitical and social environment of three Western Balkan states: Montenegro, …