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Evaluation Of Biruh Tesfa (Bright Future) For All: A Program For Out-Of-School Girls, Migrants, And Domestic Workers In Low-Income Ethiopian Cities, Annabel Erulkar, Eyasu Hailu, Henock Markos, Getnet Demissie, Tsegahun Tessema, Hana Hailu Jun 2023

Evaluation Of Biruh Tesfa (Bright Future) For All: A Program For Out-Of-School Girls, Migrants, And Domestic Workers In Low-Income Ethiopian Cities, Annabel Erulkar, Eyasu Hailu, Henock Markos, Getnet Demissie, Tsegahun Tessema, Hana Hailu

Adolescents and Young People

Biruh Tesfa (“Bright Future)” is the name of a program designed in the mid-2000s to address the disadvantage of out-of-school girls in urban Ethiopia. The program was originally designed to address social isolation by bringing girls together in safe spaces groups with adult female mentors and providing them with skills-building activities, including life skills, reproductive health, HIV education, nonformal education and referrals, and training. This evaluation examines various aspects of the Biruh Tesfa for All Program: characteristics of beneficiaries, including domestic workers; patterns of attendance, absenteeism, and dropout; indicators of mental health such as self-reported anxiety, sadness, and depression; and …


Sex Education In American Public Schools: Policy And Outcomes, Alexandra Mattingly Jun 2023

Sex Education In American Public Schools: Policy And Outcomes, Alexandra Mattingly

University Honors Theses

Sexual Education in American public schools is the subject of a long-standing debate between educators, parents, and policy makers. From the beginning of public schooling in the United States, the role that public schools ought to serve in educating students about sexual health has been unclear. This remains a topic of debate despite the fact that since the 1980s studies have shown consistently that comprehensive sexual education unequivocally leads to lower rates of pregnancy and sexually transmitted infection spread among students. Comprehensive sexual education is sexual education that includes information on safer sexual activity practices as well as information about …


From The Closet To The Campaign Trail: Navigating Disclosure Of Sexual Orientation In Campaign Media Content By Openly Lesbian Political Candidates In The Oregon 2022 Election Cycle, Bridget D. Volk Jun 2023

From The Closet To The Campaign Trail: Navigating Disclosure Of Sexual Orientation In Campaign Media Content By Openly Lesbian Political Candidates In The Oregon 2022 Election Cycle, Bridget D. Volk

University Honors Theses

This qualitative study examines the strategies employed by openly lesbian political candidates in navigating the disclosure of their sexual orientation within campaign media content during the Oregon 2022 election cycle. The project uses Tina Kotek, a candidate for Oregon governor, and Jamie McLeod-Skinner, a candidate for Oregon House District 5, as case studies. The thesis comprises of four main sections, each focusing on a specific aspect of campaign media content: analysis of the biography sections on each candidate's campaign website, examination of two selected social media posts from each candidate, analysis of two television advertisements for each candidate, and a …


Certification Of Pondok Pesantren As Professional Nazhir To Develop Productive Waqf, Salawat Fatih Ibrahim Jun 2023

Certification Of Pondok Pesantren As Professional Nazhir To Develop Productive Waqf, Salawat Fatih Ibrahim

Journal Of Middle East and Islamic Studies

Waqf is one of the potential financial instruments in Islamic economics. As a country with the largest Muslim population in the world, Indonesia has responded positively to developments in the waqf model, especially productive waqf. The waqf potential predicted in 2024 will reach 71.8 trillion, while the realization of waqf is only 199 billion. This means that there is a gap of up to 71.6 trillion between the waqf potential and its realization. This occurs as a result of the lack of knowledge about waqf, including nazhir as the manager of waqf assets. Moreover, the majority of nazirs in Indonesia …


The Urgency And Strategic Role Of Maqasid Shari'ah And Maslahah In Responding To The Legal And Economic Challenges Of Muslim Business, Fadhli Suko Wiryanto Jun 2023

The Urgency And Strategic Role Of Maqasid Shari'ah And Maslahah In Responding To The Legal And Economic Challenges Of Muslim Business, Fadhli Suko Wiryanto

Journal Of Middle East and Islamic Studies

The study of maqashid shari'ah began to receive intensive attention after the Prophet's death, especially when the Companions were faced with new problems and social changes that had never occurred when the Prophet Muhammad was still alive. With the existence of social changes as a result of the demands of the times and the dynamics of society, thus demanding the creativity of the friends seriously to conduct a study of the maqashid shari'ah as an effort to make legal breakthroughs to anticipate social changes that occur. Maqashid shari'ah and maslahat have a very urgent and strategic role to be used …


The Concept Of Hadith, Meaning, And Position Of Hadith, Implementation And Comparison In Hadith Learning Application: Hadith Encyclopedia And Hadith Collection, Nurul Anggraeni Shinta Ilahi, Nurwahidin Nurwahidin, Mohammad Izdiyan Jun 2023

The Concept Of Hadith, Meaning, And Position Of Hadith, Implementation And Comparison In Hadith Learning Application: Hadith Encyclopedia And Hadith Collection, Nurul Anggraeni Shinta Ilahi, Nurwahidin Nurwahidin, Mohammad Izdiyan

Journal Of Middle East and Islamic Studies

The rapid development of information and communication technology has added new perspectives to research on the concept of hadith, the meaning, and position of hadith, which can also be seen as an effort to improve, enforce, and preserve hadith among the Muslim community in the online realm. The results of this study identified two specific mobile applications, namely the Hadith Encyclopedia and the Hadith Collection. This research aims to test several mobile applications that can be used to speed up the learning process and show how simple the verification and authentication of a hadith is in modern times. Hadith data …


Philanthropic Traditions In Religions; A Comparative Study Of Jews, Islam, And Christianity, Ahmad Sobiyanto, Nurwahidin Nurwahidin Jun 2023

Philanthropic Traditions In Religions; A Comparative Study Of Jews, Islam, And Christianity, Ahmad Sobiyanto, Nurwahidin Nurwahidin

Journal Of Middle East and Islamic Studies

The philanthropic tradition is one of the recommended acts of worship in Islam which is part of the pillar of Islam, zakat. However, it turns out that this tradition also developed in other religions and became interesting to learn. The purpose of this study is to describe qualitatively about philanthropic traditions in the teachings of major religions in the middle east, namely Judaism, Islam, and Christianity. Descriptive qualitative method (using content analysis techniques) is a type of literature research through books, journals and other relevant sources used in this research. That the religions of Judaism, Islam, and Christianity each have …


Terrain Characterization Via Machine Vs. Deep Learning Using Remote Sensing, Jordan Ewing, Thomas Oommen, Jobin Thomas, Anush Kasaragod, Richard Dobson, Colin Brooks, Paramsothy Jayakumar, Michael Cole, Tulga Ersal Jun 2023

Terrain Characterization Via Machine Vs. Deep Learning Using Remote Sensing, Jordan Ewing, Thomas Oommen, Jobin Thomas, Anush Kasaragod, Richard Dobson, Colin Brooks, Paramsothy Jayakumar, Michael Cole, Tulga Ersal

Michigan Tech Publications, Part 1

Terrain traversability is critical for developing Go/No-Go maps for ground vehicles, which significantly impact a mission’s success. To predict the mobility of terrain, one must understand the soil characteristics. In-situ measurements performed in the field are the current method of collecting this information, which is time-consuming, costly, and can be lethal for military operations. This paper investigates an alternative approach using thermal, multispectral, and hyperspectral remote sensing from an unmanned aerial vehicle (UAV) platform. Remotely sensed data combined with machine learning (linear, ridge, lasso, partial least squares (PLS), support vector machines (SVM), and k nearest neighbors (KNN)) and deep learning …


Influence Of Organics And Gas Mixing On Hydrogen/Brine And Methane/Brine Wettability Using Jordanian Oil Shale Rocks: Implications For Hydrogen Geological Storage, Amer Alanazi, Nurudeen Yekeen, Mujahid Ali, Muhammad Ali, Israa S. Abu-Mahfouz, Alireza Keshavarz, Stefan Iglauer, Hussein Hoteit Jun 2023

Influence Of Organics And Gas Mixing On Hydrogen/Brine And Methane/Brine Wettability Using Jordanian Oil Shale Rocks: Implications For Hydrogen Geological Storage, Amer Alanazi, Nurudeen Yekeen, Mujahid Ali, Muhammad Ali, Israa S. Abu-Mahfouz, Alireza Keshavarz, Stefan Iglauer, Hussein Hoteit

Research outputs 2022 to 2026

The substitution of fossil fuel with clean hydrogen (H2) has been identified as a promising route to achieve net zero carbon emissions by this century. However, enough H2 must be stored underground at an industrial scale to achieve this objective due to the low volumetric energy density of H2. In underground H2 storage, cushion gases, such as methane (CH4), are required to maintain a safe operational formation pressure during the withdrawal or injection of H2. The wetting characteristics of geological formations in the presence of H2, cushion gas, …


Longitudinal Analysis Of Change In Mammographic Density In Each Breast And Its Association With Breast Cancer Risk, Shu Jiang, Debbie L Bennett, Bernard A Rosner, Graham A Colditz Jun 2023

Longitudinal Analysis Of Change In Mammographic Density In Each Breast And Its Association With Breast Cancer Risk, Shu Jiang, Debbie L Bennett, Bernard A Rosner, Graham A Colditz

2020-Current year OA Pubs

IMPORTANCE: Although breast density is an established risk factor for breast cancer, longitudinal changes in breast density have not been extensively studied to determine whether this factor is associated with breast cancer risk.

OBJECTIVE: To prospectively evaluate the association between change in mammographic density in each breast over time and risk of subsequent breast cancer.

DESIGN, SETTING, AND PARTICIPANTS: This nested case-control cohort study was sampled from the Joanne Knight Breast Health Cohort of 10 481 women free from cancer at entry and observed from November 3, 2008, to October 31, 2020, with routine screening mammograms every 1 to 2 …


Acinetobacter Baumannii Atcc 17978 Encodes A Microcin System With Antimicrobial Properties For Contact-Independent Competition, Fabiana Bisaro, Howard A Shuman, Mario F Feldman, Michael J Gebhardt, Stefan Pukatzki Jun 2023

Acinetobacter Baumannii Atcc 17978 Encodes A Microcin System With Antimicrobial Properties For Contact-Independent Competition, Fabiana Bisaro, Howard A Shuman, Mario F Feldman, Michael J Gebhardt, Stefan Pukatzki

2020-Current year OA Pubs

No abstract provided.


Crypticproteindb: An Integrated Database Of Proteome And Immunopeptidome Derived Non-Canonical Cancer Proteins, Ghofran Othoum, Christopher A Maher Jun 2023

Crypticproteindb: An Integrated Database Of Proteome And Immunopeptidome Derived Non-Canonical Cancer Proteins, Ghofran Othoum, Christopher A Maher

2020-Current year OA Pubs

Translated non-canonical proteins derived from noncoding regions or alternative open reading frames (ORFs) can contribute to critical and diverse cellular processes. In the context of cancer, they also represent an under-appreciated source of targets for cancer immunotherapy through their tumor-enriched expression or by harboring somatic mutations that produce neoantigens. Here, we introduce the largest integration and proteogenomic analysis of novel peptides to assess the prevalence of non-canonical ORFs (ncORFs) in more than 900 patient proteomes and 26 immunopeptidome datasets across 14 cancer types. The integrative proteogenomic analysis of whole-cell proteomes and immunopeptidomes revealed peptide support for a nonredundant set of …


Characterization Of Cell-Type Specific Circular Rnas Associated With Colorectal Cancer Metastasis, Sidi Zhao, Amy Ly, Jacqueline L Mudd, Emily B Rozycki, Jace Webster, Emily Coonrod, Ghofran Othoum, Jingqin Luo, Ha X Dang, Ryan C Fields, Christopher A Maher Jun 2023

Characterization Of Cell-Type Specific Circular Rnas Associated With Colorectal Cancer Metastasis, Sidi Zhao, Amy Ly, Jacqueline L Mudd, Emily B Rozycki, Jace Webster, Emily Coonrod, Ghofran Othoum, Jingqin Luo, Ha X Dang, Ryan C Fields, Christopher A Maher

2020-Current year OA Pubs

Colorectal cancer (CRC) is the most common gastrointestinal malignancy and a leading cause of cancer deaths in the United States. More than half of CRC patients develop metastatic disease (mCRC) with an average 5-year survival rate of 13%. Circular RNAs (circRNAs) have recently emerged as important tumorigenesis regulators; however, their role in mCRC progression remains poorly characterized. Further, little is known about their cell-type specificity to elucidate their functions in the tumor microenvironment (TME). To address this, we performed total RNA sequencing (RNA-seq) on 30 matched normal, primary and metastatic samples from 14 mCRC patients. Additionally, five CRC cell lines …


Tachlīlu Manhaji Kitābati Al-‘Arabiyyah Fī Kurrāsati Ath-Tharīqti Al-Chamīdiyyati Fī Tachsīni Al-Kitābati Al-I’Tiyādiyyati, Ahmad Yasir Amrulloh, Ato'illah Ato'illah Jun 2023

Tachlīlu Manhaji Kitābati Al-‘Arabiyyah Fī Kurrāsati Ath-Tharīqti Al-Chamīdiyyati Fī Tachsīni Al-Kitābati Al-I’Tiyādiyyati, Ahmad Yasir Amrulloh, Ato'illah Ato'illah

Al-Arabi: Journal of Teaching Arabic as a Foreign Language

The lack of learners in understanding Arabic writing rules properly makes it difficult for them to write Arabic-based texts, especially those with beginner backgrounds from the lay community, so special methods are needed to deal with these problems. T


Defects In Lysosomal Function And Lipid Metabolism In Human Microglia Harboring A Trem2 Loss Of Function Mutation, Fabia Filipello, Shih-Feng You, Farzaneh S Mirfakhar, Sidhartha Mahali, Bryan Bollman, Mariana Acquarone, Jacob A Marsh, Anirudh Sivaraman, Rita Martinez, Claudia Cantoni, Luca De Feo, Laura Ghezzi, Miguel A Minaya, Arun Renganathan, Anil G Cashikar, Wandy Beatty, Abhirami K Iyer, Marina Cella, Laura Piccio, Celeste M Karch, Et Al. Jun 2023

Defects In Lysosomal Function And Lipid Metabolism In Human Microglia Harboring A Trem2 Loss Of Function Mutation, Fabia Filipello, Shih-Feng You, Farzaneh S Mirfakhar, Sidhartha Mahali, Bryan Bollman, Mariana Acquarone, Jacob A Marsh, Anirudh Sivaraman, Rita Martinez, Claudia Cantoni, Luca De Feo, Laura Ghezzi, Miguel A Minaya, Arun Renganathan, Anil G Cashikar, Wandy Beatty, Abhirami K Iyer, Marina Cella, Laura Piccio, Celeste M Karch, Et Al.

2020-Current year OA Pubs

TREM2 is an innate immune receptor expressed by microglia in the adult brain. Genetic variation in the TREM2 gene has been implicated in risk for Alzheimer's disease and frontotemporal dementia, while homozygous TREM2 mutations cause a rare leukodystrophy, Nasu-Hakola disease (NHD). Despite extensive investigation, the role of TREM2 in NHD pathogenesis remains poorly understood. Here, we investigate the mechanisms by which a homozygous stop-gain TREM2 mutation (p.Q33X) contributes to NHD. Induced pluripotent stem cell (iPSC)-derived microglia (iMGLs) were generated from two NHD families: three homozygous TREM2 p.Q33X mutation carriers (termed NHD), two heterozygous mutation carriers, one related non-carrier, and two …


Cortical Adaptation Of The Night Monkey To A Nocturnal Niche Environment: A Comparative Non-Invasive T1w/T2w Myelin Study, Takuro Ikeda, Joonas A Autio, Akihiro Kawasaki, Chiho Takeda, Takayuki Ose, Masahiko Takada, David C Van Essen, Matthew F Glasser, Takuya Hayashi Jun 2023

Cortical Adaptation Of The Night Monkey To A Nocturnal Niche Environment: A Comparative Non-Invasive T1w/T2w Myelin Study, Takuro Ikeda, Joonas A Autio, Akihiro Kawasaki, Chiho Takeda, Takayuki Ose, Masahiko Takada, David C Van Essen, Matthew F Glasser, Takuya Hayashi

2020-Current year OA Pubs

Night monkeys (Aotus) are the only genus of monkeys within the Simian lineage that successfully occupy a nocturnal environmental niche. Their behavior is supported by their sensory organs' distinctive morphological features; however, little is known about their evolutionary adaptations in sensory regions of the cerebral cortex. Here, we investigate this question by exploring the cortical organization of night monkeys using high-resolution in-vivo brain MRI and comparative cortical-surface T1w/T2w myeloarchitectonic mapping. Our results show that the night monkey cerebral cortex has a qualitatively similar but quantitatively different pattern of cortical myelin compared to the diurnal macaque and marmoset monkeys. T1w/T2w myelin …


Validation Of A Predictive Model For Hospital-Acquired Acute Kidney Injury With Emergence Of Sars-Cov-2 Variants, Meredith C Mcadams, Pin Xu, Michael Li, L Parker Gregg, Sameh N Saleh, Mauricio Ostrosky-Frid, Duwayne L Willett, Ferdinand Velasco, Christoph U Lehmann, S Susan Hedayati Jun 2023

Validation Of A Predictive Model For Hospital-Acquired Acute Kidney Injury With Emergence Of Sars-Cov-2 Variants, Meredith C Mcadams, Pin Xu, Michael Li, L Parker Gregg, Sameh N Saleh, Mauricio Ostrosky-Frid, Duwayne L Willett, Ferdinand Velasco, Christoph U Lehmann, S Susan Hedayati

Faculty, Staff and Students Publications

We previously developed and validated a model to predict acute kidney injury (AKI) in hospitalized coronavirus disease 2019 (COVID-19) patients and found that the variables with the highest importance included a history of chronic kidney disease and markers of inflammation. Here, we assessed model performance during periods when COVID-19 cases were attributable almost exclusively to individual variants. Electronic Health Record data were obtained from patients admitted to 19 hospitals. The outcome was hospital-acquired AKI. The model, previously built in an


Genetic Studies Of Paired Metabolomes Reveal Enzymatic And Transport Processes At The Interface Of Plasma And Urine, Pascal Schlosser, Nora Scherer, Franziska Grundner-Culemann, Sara Monteiro-Martins, Stefan Haug, Inga Steinbrenner, Burulça Uluvar, Matthias Wuttke, Yurong Cheng, Arif B Ekici, Gergely Gyimesi, Edward D Karoly, Fruzsina Kotsis, Johanna Mielke, Maria F Gomez, Bing Yu, Morgan E Grams, Josef Coresh, Eric Boerwinkle, Michael Köttgen, Florian Kronenberg, Heike Meiselbach, Robert P Mohney, Shreeram Akilesh, Gckd Investigators, Miriam Schmidts, Matthias A Hediger, Ulla T Schultheiss, Kai-Uwe Eckardt, Peter J Oefner, Peggy Sekula, Yong Li, Anna Köttgen Jun 2023

Genetic Studies Of Paired Metabolomes Reveal Enzymatic And Transport Processes At The Interface Of Plasma And Urine, Pascal Schlosser, Nora Scherer, Franziska Grundner-Culemann, Sara Monteiro-Martins, Stefan Haug, Inga Steinbrenner, Burulça Uluvar, Matthias Wuttke, Yurong Cheng, Arif B Ekici, Gergely Gyimesi, Edward D Karoly, Fruzsina Kotsis, Johanna Mielke, Maria F Gomez, Bing Yu, Morgan E Grams, Josef Coresh, Eric Boerwinkle, Michael Köttgen, Florian Kronenberg, Heike Meiselbach, Robert P Mohney, Shreeram Akilesh, Gckd Investigators, Miriam Schmidts, Matthias A Hediger, Ulla T Schultheiss, Kai-Uwe Eckardt, Peter J Oefner, Peggy Sekula, Yong Li, Anna Köttgen

Faculty, Staff and Students Publications

The kidneys operate at the interface of plasma and urine by clearing molecular waste products while retaining valuable solutes. Genetic studies of paired plasma and urine metabolomes may identify underlying processes. We conducted genome-wide studies of 1,916 plasma and urine metabolites and detected 1,299 significant associations. Associations with 40% of implicated metabolites would have been missed by studying plasma alone. We detected urine-specific findings that provide information about metabolite reabsorption in the kidney, such as aquaporin (AQP)-7-mediated glycerol transport, and different metabolomic footprints of kidney-expressed proteins in plasma and urine that are consistent with their localization and function, including the …


Divergent Clinical Presentations And Outcomes Among Children And Adolescents With Kaposi Sarcoma In Malawi And Tanzania, Liane R Campbell, Allison Silverstein, Erin Peckham-Gregory, William Kamiyango, Jimmy Villiera, Casey L Mcatee, Jason M Bacha, Carrie L Kovarik, Parth S Mehta, Toni Chanroo, Asulwisye Kapesa, Beatrice Malingoti, Rizine Mzikamanda, Nmazuo W Ozuah, Carl E Allen, Michael E Scheurer, Nader K El-Mallawany Jun 2023

Divergent Clinical Presentations And Outcomes Among Children And Adolescents With Kaposi Sarcoma In Malawi And Tanzania, Liane R Campbell, Allison Silverstein, Erin Peckham-Gregory, William Kamiyango, Jimmy Villiera, Casey L Mcatee, Jason M Bacha, Carrie L Kovarik, Parth S Mehta, Toni Chanroo, Asulwisye Kapesa, Beatrice Malingoti, Rizine Mzikamanda, Nmazuo W Ozuah, Carl E Allen, Michael E Scheurer, Nader K El-Mallawany

Center for Medical Ethics and Health Policy Staff Publications

Objectives: The Kaposi sarcoma (KS) T0 versus T1 staging classification does not address the unique clinical features of paediatric KS in human gammaherpesvirus 8 (HHV-8) endemic regions of Africa. This study seeks to define patterns of childhood KS using a paediatric-specific approach.

Methods: The Lilongwe paediatric KS staging classification categorizes disease based on clinical phenotype: stage 1 = mild/moderate KS limited to cutaneous/oral involvement, stage 2 = primarily lymphadenopathic disease, stage 3 = woody edema KS, stage 4 = visceral and/or severe/disseminated mucocutaneous disease. Characteristics and outcomes were evaluated from paediatric referral centres in Lilongwe, Malawi, and Mbeya, Tanzania.

Results: …


Discordant Calls Across Genotype Discovery Approaches Elucidate Variants With Systematic Errors, Elizabeth G Atkinson, Mykyta Artomov, Alexander A Loboda, Heidi L Rehm, Daniel G Macarthur, Konrad J Karczewski, Benjamin M Neale, Mark J Daly Jun 2023

Discordant Calls Across Genotype Discovery Approaches Elucidate Variants With Systematic Errors, Elizabeth G Atkinson, Mykyta Artomov, Alexander A Loboda, Heidi L Rehm, Daniel G Macarthur, Konrad J Karczewski, Benjamin M Neale, Mark J Daly

Faculty, Staff and Students Publications

Large-scale high-throughput sequencing data sets have been transformative for informing clinical variant interpretation and for use as reference panels for statistical and population genetic efforts. Although such resources are often treated as ground truth, we find that in widely used reference data sets such as the Genome Aggregation Database (gnomAD), some variants pass gold-standard filters, yet are systematically different in their genotype calls across genotype discovery approaches. The inclusion of such discordant sites in study designs involving multiple genotype discovery strategies could bias results and lead to false-positive hits in association studies owing to technological artifacts rather than a true …


Beyond The Treatment: The Role Of Race, Sex, And Education In Health Trajectories Between Cancer Survivors And Noncancer Older Adults, Minzhi Ye, Eva Kahana, Gary Deimling, Adam Perzynski, Kurt Stange Jun 2023

Beyond The Treatment: The Role Of Race, Sex, And Education In Health Trajectories Between Cancer Survivors And Noncancer Older Adults, Minzhi Ye, Eva Kahana, Gary Deimling, Adam Perzynski, Kurt Stange

School of Social Work Faculty Publications

Introduction:

The number of older, long-term cancer survivors is increasing. However, little is known about how cancer and aging affect the health trajectories of older adults differently. In addition, the impact of race, sex, and education on the processes of aging and the cancer experience needs further investigation. The current study aims to address this knowledge gap by combining two National Cancer Institute (NIC)-funded longitudinal studies conducted in Cleveland from 1998 to 2010.

Materials and Methods:

The unique cross-sequential design facilitates a comparison between the health changes in long-term (five years +) older cancer survivors (breast, prostate, and colorectal cancer) …


Effects Of Individual Strategies For Resource Access On Collaboratively Maintained Irrigation Infrastructure, Jordan L. Stern, Afreen Siddiqi, Paul N. Grogan Jun 2023

Effects Of Individual Strategies For Resource Access On Collaboratively Maintained Irrigation Infrastructure, Jordan L. Stern, Afreen Siddiqi, Paul N. Grogan

Faculty Publications

Built infrastructure for water and energy supply, transportation, and other such services underpins human well-being and socioeconomic development. A fundamental understanding of how infrastructure design and user strategies interact can guide important design decisions as well as policy formulation for ensuring long-term infrastructure viability in conjunction with improved individual user benefits. In this work, an agent based model (ABM) is developed to study this issue for the specific case of irrigation canals. Cooperatively maintained irrigation canals serve essential roles in sustaining agriculture-based economies in many regions. Canal system design can strongly affect benefits derived by distributed users, regional agricultural output, …


Studies On The Leukocyte-Associated Ig-Like Inhibitory Receptor-1 Signaling Pathway In T Lymphocytes, Chidi Zacheaus Jun 2023

Studies On The Leukocyte-Associated Ig-Like Inhibitory Receptor-1 Signaling Pathway In T Lymphocytes, Chidi Zacheaus

Theses and Dissertations (ETD)

Inflammation is a natural process in which the immune system concertedly responds to pathogens and abnormal cell growth to protect the host. For an efficient/effective immune response that circumvents tissue atrophy, a delicate balance between stimulatory and inhibitory mechanisms is essential for the proper functioning of the immune system. Immuno-receptor Tyrosine-based Inhibitory Motif (ITIM)-bearing receptors in immune cells, including T lymphocytes, play a major role in preventing autoimmune responses. Leukocyte-associated Ig-like Inhibitory Receptor 1 (LAIR-1) is one of ITIM-bearing receptors. The mechanism by which LAIR-1 attenuates T-cell response has yet to be completely understood. In this study, I investigated a …


Impact Of Social Media On Academic Performance Of University Female Students Of Khushal Khan Khattak University Pakistan, Saeed Ullah Jan Jun 2023

Impact Of Social Media On Academic Performance Of University Female Students Of Khushal Khan Khattak University Pakistan, Saeed Ullah Jan

Library Philosophy and Practice (e-journal)

Due to the rapid development of the Internet and communication technologies, social media has become an essential part of our daily lives. It enables people to interact and share information without being limited by location or time. Consequently, social media's influence has extended to various aspects of society, including higher education. Students in higher educational institutions now utilize social media for both academic and non-academic purposes. Therefore, it has become crucial to understand how social media affects students' academic performance. Although many studies have explored the use of social media in higher education, there remains a significant gap in understanding …


Modeling Potential Damages Of Hurricanes At The Facility Scale: A Case Study Of Eglin Air Force Base, Alexander J. Baldwin, Christopher M. Chini, Steven J. Schuldt, Justin D. Delorit Jun 2023

Modeling Potential Damages Of Hurricanes At The Facility Scale: A Case Study Of Eglin Air Force Base, Alexander J. Baldwin, Christopher M. Chini, Steven J. Schuldt, Justin D. Delorit

Faculty Publications

Tropical cyclones have intensified and are expected to strengthen throughout the 21st century due to climate change impacts. Storm intensification poses a serious threat to coastal municipalities and infrastructure that are not designed to withstand future wind and storm surge potential. Coupled modeling software has been widely used to replicate extreme weather events and simulate climate change effects to understand the magnitude of vulnerability coastal regions face. However, these studies are often conducted at too coarse resolutions to provide decision makers with actionable information for facility-level adaptation. This study addresses this limitation using a coupled modeling approach by simulating climate-intensified …


Association Of Area Deprivation Index With Severity Of Covid-19 In Pediatric Patients: A Multisite Study Of Racially And Ethnically Diverse Children, Sebastian Acosta, Srinivasan Suresh, Anna K Ettinger, Fabio Savorgnan, Ananth Annapragada, Nirupama Kannikeswaran, Usha Sethuraman Jun 2023

Association Of Area Deprivation Index With Severity Of Covid-19 In Pediatric Patients: A Multisite Study Of Racially And Ethnically Diverse Children, Sebastian Acosta, Srinivasan Suresh, Anna K Ettinger, Fabio Savorgnan, Ananth Annapragada, Nirupama Kannikeswaran, Usha Sethuraman

Faculty, Staff and Students Publications

Area deprivation index (ADI) is associated with the risk of severe COVID-19 in adults. However, this association has not been established in children. Information on ADI, demographics, clinical features, disease severity, and outcomes was analyzed for 3434 children with COVID-19. A multivariate logistic regression revealed that non-Hispanic Asians, extremes of weight, and higher ADI were associated with severe disease.


A Novel Through-The-Scope Helix Tack-And-Suture Device For Mucosal Defect Closure Following Colorectal Endoscopic Submucosal Dissection: A Multicenter Study, Jad Farha, Hemchand Ramberan, Hiroyuki Aihara, Linda Y Zhang, Amit Mehta, Camille Hage, Alexander Schlachterman, Anand Kumar, Brianna Shinn, Andrew Canakis, Raymond E Kim, Lionel S DʼSouza, Jonathan M Buscaglia, Andrew C Storm, Jason Samarasena, Kenneth Chang, Shai Friedland, Peter V Draganov, Bashar J Qumseya, Salmaan Jawaid, Mohamed O Othman, Muhammad K Hasan, Dennis Yang, Mouen A Khashab, Saowanee Ngamruengphong, Esd-Closure Working Group Jun 2023

A Novel Through-The-Scope Helix Tack-And-Suture Device For Mucosal Defect Closure Following Colorectal Endoscopic Submucosal Dissection: A Multicenter Study, Jad Farha, Hemchand Ramberan, Hiroyuki Aihara, Linda Y Zhang, Amit Mehta, Camille Hage, Alexander Schlachterman, Anand Kumar, Brianna Shinn, Andrew Canakis, Raymond E Kim, Lionel S DʼSouza, Jonathan M Buscaglia, Andrew C Storm, Jason Samarasena, Kenneth Chang, Shai Friedland, Peter V Draganov, Bashar J Qumseya, Salmaan Jawaid, Mohamed O Othman, Muhammad K Hasan, Dennis Yang, Mouen A Khashab, Saowanee Ngamruengphong, Esd-Closure Working Group

Faculty, Staff and Students Publications

Background: Complete closure of large mucosal defects following colorectal endoscopic submucosal dissection (ESD) with through-the-scope (TTS) clips is oftentimes not possible. We aimed to report our early experience of using a novel TTS suturing system for the closure of large mucosal defects after colorectal ESD.

Methods: We performed a retrospective multicenter cohort study of consecutive patients who underwent attempted prophylactic defect closure using the TTS suturing system after colorectal ESD. The primary outcome was technical success in achieving complete defect closure, defined as a < 5 mm residual mucosal defect in the closure line using TTS suturing, with or without adjuvant TTS clips.

Results: 82 patients with a median defect size of 30 (interquartile range 25-40) mm were included. …


Fetal Malrotation With Midgut Volvulus: Prenatal Diagnosis And Planning, Oluyinka O Olutoye, J D Hammond, Jamie Gilley, Ross M Beckman, Marie Bulathsinghala, Sonya S Keswani, Jonathan Davies, Mark V Mazziotti, Roopali Donepudi, Michael A Belfort, Alice King, Pamela M Ketwaroo, Timothy C Lee Jun 2023

Fetal Malrotation With Midgut Volvulus: Prenatal Diagnosis And Planning, Oluyinka O Olutoye, J D Hammond, Jamie Gilley, Ross M Beckman, Marie Bulathsinghala, Sonya S Keswani, Jonathan Davies, Mark V Mazziotti, Roopali Donepudi, Michael A Belfort, Alice King, Pamela M Ketwaroo, Timothy C Lee

Faculty, Staff and Students Publications

Introduction: Malrotation of the intestinal tract is a congenital malformation commonly found either incidentally or after affected individuals develop signs and symptoms of intestinal obstruction. Malrotation is prone to midgut volvulus that can cause intestinal obstruction and lead to ischemia and necrosis requiring emergent surgical intervention. Rare instances of in utero midgut volvulus have been reported in the literature and carry a high mortality given the difficulty in establishing a diagnosis prior to development of signs of intestinal ischemia and necrosis. Advancements in imaging have made it possible to diagnose in utero malrotation earlier, raising the question of optimal timing …


When Patient Rudeness Impacts Care: A Review Of Incivility In Healthcare, Alexandra Townsley, Jennifer Li-Wang, Rajani Katta Jun 2023

When Patient Rudeness Impacts Care: A Review Of Incivility In Healthcare, Alexandra Townsley, Jennifer Li-Wang, Rajani Katta

Faculty, Staff and Students Publications

Healthcare workers increasingly face incivility and rude behaviors from patients, families, and visitors. Although these are less severe than other types of mistreatment, studies have documented that they may still impact healthcare worker well-being and patient care. Defining and measuring incivility can be challenging because current research relies on the perceptions of the targets. Furthermore, there is often overlap among different types of mistreatment, and much of it goes unreported by those who experience it. Nevertheless, multiple studies have documented that incivility is common in healthcare and has been associated with burnout and intent to leave. In clinical settings, multiple …


Imaging Of Pediatric Cardiac Tumors: A Cog Diagnostic Imaging Committee/Spr Oncology Committee White Paper, Cara E Morin, Lindsay M Griffin, Rebecca S Beroukhim, Pablo Caro-Domínguez, Sherwin Chan, Jason N Johnson, Juan C Infante, Christopher Z Lam, Ladonna J Malone, Elizabeth R Tang, Michael D Taylor, James C Wilkinson, Prakash M Masand Jun 2023

Imaging Of Pediatric Cardiac Tumors: A Cog Diagnostic Imaging Committee/Spr Oncology Committee White Paper, Cara E Morin, Lindsay M Griffin, Rebecca S Beroukhim, Pablo Caro-Domínguez, Sherwin Chan, Jason N Johnson, Juan C Infante, Christopher Z Lam, Ladonna J Malone, Elizabeth R Tang, Michael D Taylor, James C Wilkinson, Prakash M Masand

Faculty, Staff and Students Publications

Cardiac tumors in children are rare and the majority are benign. The most common cardiac tumor in children is rhabdomyoma, usually associated with tuberous sclerosis complex. Other benign cardiac masses include fibromas, myxomas, hemangiomas, and teratomas. Primary malignant cardiac tumors are exceedingly rare, with the most common pathology being soft tissue sarcomas. This paper provides consensus-based imaging recommendations for the evaluation of patients with cardiac tumors at diagnosis and follow-up, including during and after therapy.