Digital Commons Network^™

Experimental Testing And Constitutive Modelling Of Pavement Materials, Xueyan Liu, Yuqing Zhang, Zhanping You, Linbing Wang, Changhong Zhou

Michigan Tech Publications, Part 1

No abstract provided.

Connective Tissue Presentation In Two Families Expands The Phenotypic Spectrum Of Pyroxd1 Disorders, Frances J Evesson, Gregory Dziaduch, Samantha J Bryen, Francesca Moore, Sara Pittman, Beena Devanapalli, Leigh B Waddell, Monique M Ryan, Manoj P Menezes, Conrad C Weihl, Adviye Ayper Tolun, Craig Zaidman, Helen Young, Lesley C Adès, Sandra T Cooper

2020-Current year OA Pubs

Recessive variants in the oxidoreductase PYROXD1 are reported to cause a myopathy in 22 affected individuals from 15 families. Here, we describe two female probands from unrelated families presenting with features of a congenital connective tissue disorder including osteopenia, blue sclera, soft skin, joint hypermobility and neuromuscular junction dysfunction in addition to known features of PYROXD1 myopathy including respiratory difficulties, weakness, hypotonia and oromotor dysfunction. Proband AII:1 is compound heterozygous for the recurrent PYROXD1 variant Chr12(GRCh38):g.21452130A>G;NM_024854.5:c.464A>G;p.(N155S) and Chr12(GRCh38):g.21462019_21462022del;NM_024854.5:c.892_895del;p.(V298Mfs*4) and proband BII:1 is compound heterozygous for Chr12(GRCh38):g.21468739-21468741del;NM_024854.5:c.1488_1490del;p.(E496del) and Chr12(GRCh38):g.21467619del;NM_024854.5:c.1254+1del. RNA studies demonstrate c.892_895del;p.(V298Mfs*4) is targeted by nonsense mediated decay …

Design, Construction, And Testing Of Recombinant Dna-Based Vaccines For Protection Against Salmonella Enterica Subspecies Enterica Serovar Javiana, Ashley Edwards

LSU Doctoral Dissertations

In the United States, Salmonella Javiana is among the top 5 most common nontyphoidal Salmonella serotypes, with a 325% increase in infection rate since 1970. Globally, nontyphoidal Salmonella leads to approximately 93.8 million illnesses and 155,000 deaths annually, with disproportionate impacts in developing countries. In the United States alone, these infections lead to over $4 billion in costs, the majority of which are attributed to those expenses incurred from mortalities. The zoonotic nature of nontyphoidal Salmonellae and their ability to survive on and within vegetation mean huge economic burden potential for various agricultural industries as well, especially since some of …

Integrative Molecular Analysis Of Dna Methylation Dynamics Unveils Molecules With Prognostic Potential In Breast Cancer, Rashid Mehmood, Alanoud Alsaleh, Muzamil Y. Want, Ijaz Ahmad, Sami Siraj, Muhammad Ishtiaq, Faizah A. Alshehri, Muhammad Naseem, Noriko Yasuhara

All Works

DNA methylation acts as a major epigenetic modification in mammals, characterized by the transfer of a methyl group to a cytosine. DNA methylation plays a pivotal role in regulating normal development, and misregulation in cells leads to an abnormal phenotype as is seen in several cancers. Any mutations or expression anomalies of genes encoding regulators of DNA methylation may lead to abnormal expression of critical molecules. A comprehensive genomic study encompassing all the genes related to DNA methylation regulation in relation to breast cancer is lacking. We used genomic and transcriptomic datasets from the Cancer Genome Atlas (TGCA) Pan-Cancer Atlas, …

A High-Dimensional Microfluidic Approach For Selection Of Aptamers With Programmable Binding Affinities, Dingran Chang, Z Wang, Connor D. Flynn, Alam Mahmud, Mahmoud Labib, H Wang, Armin Geraili, Xiangling Li, Jiaqi Zhang, Edward H. Sargent, Shana O. Kelley

Peninsula Medical School

No abstract provided.

Systematic Assessment Of The Contribution Of Structural Variants To Inherited Retinal Diseases, Shu Wen, Meng Wang, Xinye Qian, Yumei Li, Keqing Wang, Jongsu Choi, Mark E Pennesi, Paul Yang, Molly Marra, Robert K Koenekoop, Irma Lopez, Anna Matynia, Michael Gorin, Ruifang Sui, Fengxia Yao, Kerry Goetz, Fernanda Belga Ottoni Porto, Rui Chen

Faculty, Staff and Students Publications

Despite increasing success in determining genetic diagnosis for patients with inherited retinal diseases (IRDs), mutations in about 30% of the IRD cases remain unclear or unsettled after targeted gene panel or whole exome sequencing. In this study, we aimed to investigate the contributions of structural variants (SVs) to settling the molecular diagnosis of IRD with whole-genome sequencing (WGS). A cohort of 755 IRD patients whose pathogenic mutations remain undefined were subjected to WGS. Four SV calling algorithms including include MANTA, DELLY, LUMPY and CNVnator were used to detect SVs throughout the genome. All SVs identified by any one of these …

Stromal And Therapy-Induced Macrophage Proliferation Promotes Pdac Progression And Susceptibility To Innate Immunotherapy, Chong Zuo, John M Baer, Brett L Knolhoff, Jad I Belle, Xiuting Liu, Angela Alarcon De La Lastra, Graham D Hogg, Natalie L Kingston, Marcus A Breden, Paarth B Dodhiawala, Daniel Cui Zhou, Varintra E Lander, C Alston James, Li Ding, Kian-Huat Lim, Ryan C Fields, William G Hawkins, Jason D Weber, Guoyan Zhao, David G Denardo, Et Al.

2020-Current year OA Pubs

Tumor-associated macrophages (TAMs) are abundant in pancreatic ductal adenocarcinomas (PDACs). While TAMs are known to proliferate in cancer tissues, the impact of this on macrophage phenotype and disease progression is poorly understood. We showed that in PDAC, proliferation of TAMs could be driven by colony stimulating factor-1 (CSF1) produced by cancer-associated fibroblasts. CSF1 induced high levels of p21 in macrophages, which regulated both TAM proliferation and phenotype. TAMs in human and mouse PDACs with high levels of p21 had more inflammatory and immunosuppressive phenotypes. p21 expression in TAMs was induced by both stromal interaction and/or chemotherapy treatment. Finally, by modeling …

Utah Florist Preferences For Local Cut Flowers, Kynda R. Curtis, Melanie Stock

All Current Publications

This fact sheet provides crucial information on wholesale florist needs and preferences for local cut flowers. The information here will enhance the ability of current and potential cut flower growers to properly assess the profit potential of their decisions and assist with the long-term sustainability of their farming operations.

Bronchopulmonary Dysplasia: Ongoing Challenges From Definitions To Clinical Care, Sushma Nuthakki, Kaashif Ahmad, Gloria Johnson, Milenka Cuevas Guaman

Faculty, Staff and Students Publications

Bronchopulmonary dysplasia (BPD) is the most common complication of extreme prematurity. Its etiology is multifactorial and is attributed to genetic susceptibility to prenatal and postnatal factors. As advancements in neonatology have led to the increased survival of premature infants, a parallel increase in the incidence of BPD has occurred. Over time, the definition and diagnostic criteria for BPD have evolved, as have management strategies. However, challenges continue to exist in the management of these infants, which is not surprising given the complexity of the disease. We summarize the key diagnostic criteria and provide insight into the challenges related to various …

Autolysosomal Exocytosis Of Lipids Protect Neurons From Ferroptosis, Isha Ralhan, Jinlan Chang, Matthew J Moulton, Lindsey D Goodman, Nathanael Y J Lee, Greg Plummer, H Amalia Pasolli, Doreen Matthies, Hugo J Bellen, Maria S Ioannou

Faculty, Staff and Students Publications

During oxidative stress neurons release lipids that are internalized by glia. Defects in this coordinated process play an important role in several neurodegenerative diseases. Yet, the mechanisms of lipid release and its consequences on neuronal health are unclear. Here, we demonstrate that lipid-protein particle release by autolysosome exocytosis protects neurons from ferroptosis, a form of cell death driven by lipid peroxidation. We show that during oxidative stress, peroxidated lipids and iron are released from neurons by autolysosomal exocytosis which requires the exocytic machinery VAMP7 and syntaxin 4. We observe membrane-bound lipid-protein particles by TEM and demonstrate that these particles are …

Intersectionality In Canada's 'Caregiver Program': The Impact Of Race, Class, And Gender On Filipina Women In The 'Global Care Chain', Taylor Simsovic

Culture, Society, and Praxis

This paper explores the experiences of migrant Filipina caregivers in Canada under the Live-in Caregiver's Program (LCP) and the subsequent Caregivers Program (CP), focusing on the intersecting factors of race, class, and gender. Through a literature review, the study investigates the distinct and precarious position occupied by Filipina migrant caregivers, who face marginalization by the Canadian government. The framework of the 'global care chain' proposed by Aggarwal and Das Gupta (2013) and the concept of the 'international transfer of caretaking' presented by Parreñas (2000) are employed to illuminate the devaluation of 'women's work,' particularly that performed by migrant Filipina and …

Idiosyncrasy Of The State And God: An Analysis On Religiosity And Ideology In Latin America, James D. Fiorenza

Culture, Society, and Praxis

In this research paper, I will be analyzing the relationship between the religiosity of Latin America in terms of popular religion and religiosity of its followers, and how it has impacted and continues to impact the political systems of Latin America in terms of ideology. I will be conducting this research by conducting three case studies following the development of my hypothesis, my research of my case nations and the collecting of all needed data. After this, I will compare all my data and establish a well-developed conclusion which accurately conveys and demonstrates this data. My research will focus on …

A Vicious Cycle: How Racialised Moral Panics Simultaneously Reproduce (And Are Reproduced By) Repressive Policing Practices, Oscar D. Sharples

Culture, Society, and Praxis

Policing and moral panics exist in a mutually reinforcing, reciprocal relationship, the harmful outcomes of which are disproportionately directed towards poor communities of colour. This paper will draw on two examples of moral panics: those surrounding Islamic terrorism and Black crime, in order to illustrate the harm that this reinforcing relationship can cause. This harm manifests itself in increasingly restrictive antiterrorism laws, Prevent initiatives, racial profiling, and internal surveillance within the Muslim community; as well as the policies of Joint Enterprise, Knife Crime Prevention Orders (KCPOs), and the strengthening of the school-to-prison pipeline, which disproportionally target Black youth. With reference …

Dynamic Architecture As An Approach To Educational Building Development, Sara Hamed Nour, Medhat Samra

Mansoura Engineering Journal

The dynamic design of our architectural environment today has become a necessity as scientific and technological development is accelerating. Since education is the basis for the advancement of society, the architecture of educational buildings must keep pace with that development. The traditional learning spaces are no longer suitable for educational curricula and the modern learning mechanism, they need dynamism, flexibility, multi-functionality, and response to the surrounding environment changes and user desires. The basis of the research is to design our educational buildings in a dynamic manner that works on the following:

• Creating a modern educational environment with flexible, versatile …

Terrorism And Growth: Evidence From India And Egypt, Nibal Ezz Eldin Attia Nibal, Ahmed Sabry Abou Zaid

Future Journal of Social Science

The impact of terrorism is different in developed and developing countries, according to many economists. But what leads to variation in the consequences of terrorism among two developing countries? This paper takes into account two developing countries from two different continents and quantifies the impact of terrorism on GDP per capita. The data is extracted and arranged from the Global Terrorism Index (Humanity, n.d.) for India and Egypt from the years 1975-2018 and 1977-2018, respectively. A set of statistical analyses using the OLS and Newey-West method is used to examine the relationship between the variables. For India, an act of …

Dialoguing Narratives Of Social Movement Theories And Subjectivities, Sarra Moneir

Future Journal of Social Science

This paper serves as a theoretical study for displaying a sample of the prime literature on social movement theories in comparison with one another, shedding light on the gaps and fundamental contributions. This will be carried out in comparison to the scholarship on subjectivity. Social movement and social movement theories have been inevitable tools of analysis since primarily the 1980s, serving as replacements for modes of apprehending popular mobilization. Since then, theoretical contributions in this field have grown and shown a multitude of orientations and focal strategies on how to focus and study social movements in their various forms and …

Good State, Bad State: Gender, Multiculturalism And Religious Law In India, Rina V. Williams

Future Journal of Social Science

What role(s) can the state play when cultural rights come into conflict with women’s rights? This article compares conceptions of the state in the normative literature against two empirical cases of multicultural debate in modern India: Islamic law in the 1980s and Hindu law in the 1950s. I find that three conceptions of the state found in the normative literature—oppressive, facilitative, and vacated states—are only partially supported in the empirical cases, which proffer some support for the state as oppressive, but little or none for the state as facilitative or vacated. They also indicate a fourth model …

Reimagining The Theory Of Necropolitics In A Modern Lens: Hate Crimes And Violence, Salma Ahmed Abdulmagied Gheita

Future Journal of Social Science

This research paper is testing the validity of the Necropolitics theory and how we can reintroduce its definitions in a modern lens. Though the theory of Necropolitics is extreme and historically was a terminology and paradigm that was used towards more catastrophic and traumatizing events. The main argument that this paper is discussing is how did the idea of Necropolitics evolved into a more institutional, systematic, and legalized manors of exclusion. This is made through critical discourse analysis of the text presented on the term Necropolitics to highlight on the history of this term and what it stood for in …

Quantifying Implicit Bias In Judicial Legal Opinions: A Natural Language Processing Approach, Philip N. Surendran

Quantitative Social Science Undergraduate Senior Theses

Implicit bias and criminal justice are two concepts that have long been intertwined. There is no justice without neutrality, and yet how do we tell if the actors enforcing the system are actually impartial? In this thesis, I utilize recent advancements in machine learning to attempt to answer this question. Specifically, I use natural language processing to examine the text of opinions written by judges in appellate courts, and I leverage these findings to build quantifiable measures of implicit bias. In particular, I look at the over/under-representation of certain emotions, sentiments and linguistic styles as a proxy for disparate treatment …

The Death Of Volunteerism In America And The True Cost To Society, John R. Ash

Pennsylvania Economic Review

Communities throughout the United States face a public safety concern in providing fire protection and emergency medical services (EMS) due to the nationwide decline in volunteerism. Two-thirds of the nation’s 30,000 fire departments are volunteer-run, and since 2015, the number of volunteer firefighters has declined from 814,850 to 682,600. EMS organizations face an equally daunting dilemma with up to a 55% attrition rate in emergency medical technicians and paramedics. Pennsylvania has been especially hard hit. Benjamin Franklin founded the first volunteer fire department in the nation in Pennsylvania. In this state, the number of volunteer firefighters has dropped from a …

A Novel Approach To Legacy Donations With Long-Term Benefits Supported By Numerical Illustrations, Daniel Solow, Robin Symes

Faculty Scholarship

Philanthropic donors face challenges in matching the causes to which they donate, the time horizon—and thus impact—of their donations, and the charitable vehicles they choose for making contributions. Wealthier donors may elect to create their own foundations and customize their charitable support. Less wealthy donors have limited choices: they may contribute to a nonprofit's current operations or to existing nonprofit endowments. We present a novel approach for making charitable donations, blending aspects of each of these strategies. Our approach has potential long-term financial benefits, allows donors to control their charitable donations in a convenient and easy-to-implement manner, can be established …

The Role Of Native Cysteine Residues In The Oligomerization Of Kcnq1 Channels, Alison Bates, Rebecca B Stowe, Elizabeth M Travis, Lauryn E Cook, Carole Dabney-Smith, Gary A Lorigan

Faculty, Staff and Student Publications

KCNQ1, the major component of the slow-delayed rectifier potassium channel, is responsible for repolarization of cardiac action potential. Mutations in this channel can lead to a variety of diseases, most notably long QT syndrome. It is currently unknown how many of these mutations change channel function and structure on a molecular level. Since tetramerization is key to proper function and structure of the channel, it is likely that mutations modify the stability of KCNQ1 oligomers. Presently, the C-terminal domain of KCNQ1 has been noted as the driving force for oligomer formation. However, truncated versions of this protein lacking the C-terminal …

Effects Of Daylight On College Students’ Physical And Mental Well-Being, Sathya Thenappan

Quantitative Social Science Undergraduate Senior Theses

While existing literature predominantly deals with the impact of daylight on adults in general and more specifically at the workplace, less is known about its impact on the college student demographic and daylight exposure levels at college residences. Given its considerable impact on both the physical and mental well-being of individuals, daylight has been used in the treatment of an assortment of diseases from seasonal affective disorder to depression. With college students constituting the majority of today’s people who suffer from mental health issues in society, uncovering the link between daylight exposure and its impact on the physical and mental …

Studying Changes In Covid-19 Vaccination Attitudes By Race Across Major Socio-Political Events, May Oo Khine

Quantitative Social Science Undergraduate Senior Theses

This thesis explores the dynamics of COVID-19 vaccination attitudes on Twitter across three specific events, focusing on changes observed within different racial groups. Understanding the shifts in public sentiment regarding COVID-19 vaccination is crucial for developing targeted interventions to improve vaccine uptake and decision-making among individuals from diverse racial backgrounds. To conduct this study, I first collected tweets from one month before and after each selected event. I built two machine learning classifiers to perform sentiment and emotion analysis on these collected tweets. Additionally, an AI facial recognition model was utilized to categorize Twitter users by race. This enabled the …

Team Versus Player? A Study Of Baseball Salary Arbitration And The Arbitrator Exchangeability Hypothesis, Devan Fink

Quantitative Social Science Undergraduate Senior Theses

I assess the decisions of arbitrators in Major League Baseball (MLB) salary arbitration hearings under the arbitrator exchangeability hypothesis. Salary arbitration occurs when a player, typically one with more than three, but fewer than six, years of major league service, cannot reach an agreement with his team on a contract for a given year. When this happens, the player and team go to an arbitration hearing. In a hearing, each side presents oral arguments in front of a panel of three independent arbitrators, proclaiming why the arbitrators should rule in their favor. The arbitrators then either decide to award the …

Using Infectious Disease Simulations To Model, Quantify, And Predict The Impact Of Self-Quarantine And Vaccination On Mpox Spread Across The United States, Amar Johanna Scherzer

Quantitative Social Science Undergraduate Senior Theses

In this paper, I build a data-driven theoretical model that reproduces the epidemiological (epi) curve of the mpox outbreak in the United States. The general framework presented in this paper considers the susceptible (S), infected (I), and recovered (R) stages of an mpox infection through an SIR model of disease spread. I use vaccination, transmissibility, recovery, and self isolation rates as parameters in my SIR model as well as a lag-time to account for the delay in vaccination roll-out. By using real-world data to inform estimates of the susceptible population and mpox transmission characteristics, I am able to simulate an …

Archaeogaming And The Re-Use Of Digital Archaeological Materials: Generating Serious Games For The Villas Of Roman Sicily, Kaitlyn Kingsland

USF Tampa Graduate Theses and Dissertations

With 10 million copies sold and 500 million dollars of revenue, the 11th installment of Ubisoft’s Assassin’s Creed series, Assassin’s Creed Odyssey (2018), showed how a videogame based on ancient Greek history and archaeology can make a splash in popular culture and that the distant past can become an extinguishable source of infinite engaging gaming narratives. As pedagogic and research counterparts to videogames of this kind, serious games and archaeogames focusing on Greek and Roman civilizations move from different premises, though aspiring to the same level of success. Serious games, created for a primary purpose other than sole entertainment, have …

What Makes An Impartial Jury? Perceptions Of Jury Impartiality And Court Legitimacy, Joshua P. Freitag

Quantitative Social Science Undergraduate Senior Theses

In light of decreasing trust in courts at all levels of the American justice system, it is more important than ever to understand what affects people’s perceptions of the courts as fair, just, and legitimate. The Black Lives Matter protests highlighted a racial element to perceptions of impartiality in the jury system. Existing literature reveals a complex historical relationship between race and the jury, but little research has been done on public perceptions of race in the jury box.

With a novel two-experiment design using a survey instrument and a half White–half Black respondent sample pool fielded using Prolific, I …

Dollarization In Latin America: The Effect On Macroeconomic Outcomes In El Salvador And Ecuador, John Stephen Petrich

Quantitative Social Science Undergraduate Senior Theses

This paper examines full dollarization in Latin America and the experience of El Salvador, Panama and Ecuador using the U.S. Dollar as their sole currency. This is accomplished by comparing key macroeconomic indicators in these countries to both their pre-dollarization experience and a control group of the largest economies in the region from 1986 to 2019. Special attention is paid to the comparison between El Salvador which fully dollarized and Guatemala which partially dollarized in 2001. A gravity model using a difference in differences analysis found no significant increase in bilateral trade with the United States relative to the control …

Sarcasm Detection In English And Arabic Tweets Using Transformer Models, Rishik Lad

Computer Science Senior Theses

This thesis describes our approach toward the detection of sarcasm and its various types in English and Arabic Tweets through methods in deep learning. There are five problems we attempted: (1) detection of sarcasm in English Tweets, (2) detection of sarcasm in Arabic Tweets, (3) determining the type of sarcastic speech subcategory for English Tweets, (4) determining which of two semantically equivalent English Tweets is sarcastic, and (5) determining which of two semantically equivalent Arabic Tweets is sarcastic. All tasks were framed as classification problems, and our contributions are threefold: (a) we developed an English binary classifier system with RoBERTa, …