Digital Commons Network^™

Kole, Isaiah Aladejobi

Masters Theses

This project focuses on the development of building blocks influenced by the architecture and design styles of Yoruba culture and Washington DC. These building blocks aim to provide an educational and culturally enriching experience for individuals of all ages, with a particular focus on youth.

By combining the traditional design elements of Yoruba architecture with the modern urban aesthetic of Washington DC, the building blocks offer a unique blend of cultural influences for children and adults to explore. Through hands-on building activities, users can engage with the cultural heritage of these two regions, while also developing important skills such as …

Sustained Alternate-Day Fasting Potentiates Doxorubicin Cardiotoxicity, Mualla Ozcan, Zhen Guo, Carla Valenzuela Ripoll, Ahmed Diab, Antonino Picataggi, David Rawnsley, Aynaz Lotfinaghsh, Carmen Bergom, Jeff Szymanski, Daniel Hwang, Jie Zheng, Robert J Hayashi, Pamela K Woodard, Attila Kovacs, Joel Schilling, Babak Razani, Abhinav Diwan, Ali Javaheri, Et Al.

2020-Current year OA Pubs

Fasting strategies are under active clinical investigation in patients receiving chemotherapy. Prior murine studies suggest that alternate-day fasting may attenuate doxorubicin cardiotoxicity and stimulate nuclear translocation of transcription factor EB (TFEB), a master regulator of autophagy and lysosomal biogenesis. In this study, human heart tissue from patients with doxorubicin-induced heart failure demonstrated increased nuclear TFEB protein. In mice treated with doxorubicin, alternate-day fasting or viral TFEB transduction increased mortality and impaired cardiac function. Mice randomized to alternate-day fasting plus doxorubicin exhibited increased TFEB nuclear translocation in the myocardium. When combined with doxorubicin, cardiomyocyte-specific TFEB overexpression provoked cardiac remodeling, while systemic …

A Look At Provincial Budgets, Ishrat Husain Dr.

Faculty Research - Newspaper and Magazine Articles

Budget discussions and debates in Pakistan have historically focused on the federal government and FBR, though the provincial budgets should occupy a salient place in the aftermath of the 18th Amendment and the 7th National Finance Commission Award. This has not been the case despite the fact that the objectives of raising the tax-to-GDP ratio and efficient and effective delivery of public goods and services to the citizens can be achieved mainly through provincial budgets.

Dinner With André: A Personal Tribute To André Hampton, David Dittfurth

St. Mary's Law Journal

No abstract provided.

Public Accommodations Originalism’S Inability To Solve The Problems Of Online Content Moderation, Vincent A. Marrazzo

St. Mary's Law Journal

In response to online platforms’ increasing ability to moderate content in what often seems to be an arbitrary way, Justice Clarence Thomas recently suggested that platforms should be regulated as public accommodations such that the government could prevent platforms from banning users or removing posts from their sites. Shortly thereafter, Florida passed the Transparency in Technology Act, which purported to regulate online platforms as public accommodations and restricted their ability to ban users, tailor content through algorithmic decision-making, and engage in their own speech. Texas followed suit by passing a similar law, and Arizona debated a bill purporting to regulate …

John Roberts And Owen Roberts: Echoes Of The Switch In Time In The Chief Justice’S Jurisprudence, Luke G. Cleland

St. Mary's Law Journal

No abstract provided.

Genotype-Degree Of Hemolysis Correlation In Hereditary Spherocytosis, Yimeng Shi, Yuan Li, Xiawan Yang, Xiaoxia Li, Guangxin Peng, Xin Zhao, Xu Liu, Yufei Zhao, Jing Hu, Xiangrong Hu, Baohang Zhang, Kang Zhou, Yang Yang, Youzhen Xiong, Jianping Li, Huihui Fan, Wenrui Yang, Lei Ye, Liping Jing, Li Zhang, Fengkui Zhang

Faculty, Staff and Student Publications

BACKGROUND: Hereditary spherocytosis (HS) is a common inherited hemolytic anemia, caused by mutations in five genes that encode erythrocyte membrane skeleton proteins. The red blood cell (RBC) lifespan could directly reflect the degree of hemolysis. In the present cohort of 23 patients with HS, we performed next-generation sequencing (NGS) and Levitt's carbon monoxide (CO) breath test to investigate the potential genotype-degree of hemolysis correlation.

RESULTS: In the present cohort, we identified 8 ANK1,9 SPTB,5 SLC4A1 and 1 SPTA1 mutations in 23 patients with HS, and the median RBC lifespan was 14(8-48) days. The median RBC lifespan of patients with ANK1, …

Input / Output, Zach Scheinfeld

Masters Theses

Input/Output emphasizes the processes and systems that create engagement, narrative, and meaning in graphic design, as opposed to singular inputs and outputs. In a series of experimental frameworks, ranging in form from 3D printed objects to browser-based painting tools, variables are put into the hands of the audience and user, creating conditions that are prime for retooling, repurposing, world-building, and play. Throughout, an open dialogue and feedback loop is formed between interface and user, author and reader, and teacher and student, where power, agency, and structure are in constant circulation, resulting in the emergence of unexpected forms, speculative technologies, and …

In A Condition Of No Light, Alana Perino

Masters Theses

In a Condition of No Light is an autofictional investigation into lineages of familial domesticity. The performances therein circumnavigate one family in one domestic environment, yet are in dialogue with repertoires learned and rehearsed within legacies of myth, literature, theater, film, music, and image; as well as through the otherwise untraceability of embodied memory and inherited trauma. The methodologies used are primarily photographic but also encompass practices reaching towards sculpture, installation, and performance. The line of questioning reserved for this inquiry is how a home, its objects, and inhabitants generate, spacialize, and embody the conditions of wealth, whiteness, and gender. …

Sit Less, Move More: A National Study Of Physical-Activity Behavior And Cancer, Stella O. Nwogugu

Dissertations

Physical activity is associated with lower risks of cancer, the second leading cause of death among Americans. Yet, sedentary behavior is the prevailing lifestyle for about 80% of American adults. Additionally, cancer survivors remain significantly inactive, even though physical activity has been shown to decrease risk of cancer and cancer recurrence, improve tolerance of cancer therapy, and reduce mortality. This research explores the relative impact of personal agency, social support, and key demographic variables on physical-activity behavior for a national sample of adults as well as how these relationships differ for cancer survivors and their counterparts.

Betty Jean Hendley Clifton

African American Funeral Programs

No abstract provided.

Integrated Dc Microgrid Testbed For Qos Evaluation, Yasin Emir Kutlu, Ruairí De Fréin, Malabika Basu, Ali Malik

Conference papers

This poster describes the development of an integrated Direct Current (DC) Microgrid (MG) testbed, consisting of power system and computer networking hardware, e.g. Cisco 4331 Integrated Services Routers (ISR) and 500W AC/DC power supplies, to test the Quality of Service (QoS) of MG control packets which are delivered over Layer-2 and Layer-3 networking topologies. It facilitates an examination of control packets between MG end-points, that enable real-time power load sharing, in the presence of background computer network traffic such as video streaming. The effects of difference levels of background traffic on the round trip time of control packets are demonstrated.

An Electric Vehicle Analysis Model For Sustainable Environment In Devoicing Nationals, Nada A. Nabeeh, Karam M. Sallam, Ali Wagdy Mohamed

Neutrosophic Systems with Applications

The usage of fossil fuels is regarded as the generation of energy alternative towards electric vehicles (EVs) in third-world nations for a cleaner transportation sector. The rapid development of EVs is the most effective solution, even if the short-term ecological benefits for third-world nations cannot cover the short-term expenses. Since ecological issues have opened the door for certain developing nations to catch up to the worldwide competition, it is important to weigh other options to bring EVs to the marketplace. Hence, the study proposes a model of neutrosophic set combined with entropy to deal with uncertain cases. The proposed model …

Message From The President, Georgia Southern University

Messages from the President

Dear Colleagues

Exploring The Risk Narratives Of Transgender People Engaged In Do-It-Yourself Hormone Replacement Therapy, Brianna Rae Cusanno

USF Tampa Graduate Theses and Dissertations

This dissertation analyzed the risk narratives of transgender people engaged in do-it- yourself hormone replacement therapy. Transgender (trans) people, those whose gender identities and/or expressions defy normative constructions of gender, experience a variety of health inequities as a consequence of systemic oppression within U.S. society. Many of the health inequities observed in trans people can be traced to structural determinants, such as discrimination at home, work, and school that results in housing, food, and social instability. Yet, medical and public health researchers have often attributed trans health inequities to “high risk” behaviors in which trans people engage.

One such behavior …

Final 2023 Residential Metals Abatement Program (Rmap) Walkerville Park (Walkerville Drive And Ryan Road) Soil Remedial Action Work Plan (Rawp), Pioneer Technical Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Care Remittances: Farmworkers' Political Knowledge And Hemispheric Information Practices During The Covid-19 Pandemic, Jennifer Martinez-Medina

Dissertations and Theses

Information is the building block of democracy. Yet, dominant political theories assume different groups within the political system acquire, process, and use information similarly, even as the golden age of globalization has sparked new forms of cross-border political exchanges. Despite a flourishing literature by interdisciplinary social scientists, gaps remain in our understanding of how transnational information circuits shape political knowledge and democratic judgments of groups in host and home countries, especially among so-called "information poor" agricultural workers who often live in precarious conditions. Using a mixed-methods analysis based on the community-engaged Oregon COVID-19 Farmworker Study (OR COFS) and interviews with …

Contextualizing The Role Of Answerers' Gaze Orientation In Turn Taking, Cassidy Moore

Dissertations and Theses

This thesis extends our understanding of the role of gaze orientation in turn taking, answering the following research question: When an answerer withdraws their gaze from a questioner at the completion point of the first turn-constructional unit of their answer, is this a practice for communicating that their answer-turn-so-far is not transition relevant (i.e., that the answerer is not complete with their turn and will continue speaking)? Data are videotapes of 274 information-seeking sequences drawn from 28 dyadic, mundane, English conversations between close friends. The methods are mixed, including conversation analysis and coding for statistical purposes. Data were transcribed for …

Targeting Cxcr4 Abrogates Resistance To Trastuzumab By Blocking Cell Cycle Progression And Synergizes With Docetaxel In Breast Cancer Treatment, Shuying Liu, Shelly M Xie, Wenbin Liu, Mihai Gagea, Ariella B Hanker, Nguyen Nguyen, Akshara Singareeka Raghavendra, Gloria Yang-Kolodji, Fuliang Chu, Sattva S Neelapu, Adriano Marchese, Samir Hanash, Johann Zimmermann, Carlos L Arteaga, Debasish Tripathy

Faculty, Staff and Student Publications

Background: Although trastuzumab and other HER2-targeted therapies have significantly improved survival in patients with HER2 overexpressed or amplified (HER2+) breast cancer, a significant proportion of patients do not respond or eventually develop clinical resistance. Strategies to reverse trastuzumab resistance remain a high clinical priority. We were the first to report the role of CXCR4 in trastuzumab resistance. The present study aims to explore the therapeutic potential of targeting CXCR4 and better understand the associated mechanisms.

Methods: Immunofluorescent staining, confocal microscopy analysis, and immunoblotting were used to analyze CXCR4 expression. BrdU incorporation assays and flow cytometry were used to analyze dynamic …

Non-Homologous End-Joining Pathway Genotypes Significantly Associated With Nasopharyngeal Carcinoma Susceptibility, Chia-Wen Tsai, Liang-Chun Shih, Wen-Shin Chang, Che-Lun Hsu, Jie-Long He, Te-Chun Hsia, Yun-Chi Wang, Jian Gu, Da-Tian Bau

Faculty, Staff and Student Publications

Defects in the non-homologous end-joining (NHEJ) DNA repair pathway lead to genomic instability and carcinogenesis. However, the roles of individual NHEJ genes in nasopharyngeal carcinoma (NPC) etiology are not well-understood. The aim of this study was to assess the contribution of NHEJ genotypes, including XRCC4 (rs6869366, rs3734091, rs28360071, rs28360317, rs1805377), XRCC5 (rs828907, rs11685387, rs9288518), XRCC6 (rs5751129, rs2267437, rs132770, rs132774), XRCC7 rs7003908, and Ligase4 rs1805388, to NPC risk, with 208 NPC patients and 416 controls. Genotype-phenotype correlations were also investigated by measuring mRNA and protein expression in adjacent normal tissues and assessing the NHEJ repair capacity in blood lymphocytes from 43 …

Brain Abscess And Stroke In Children And Adults With Hereditary Hemorrhagic Telangiectasia: Analysis Of A Large National Claims Database, Andrew J. White, Itay Marmor, Kate M. Peacock, Katelin B. Nickel, Jessica Zavadil, Margaret A. Olsen

2020-Current year OA Pubs

BACKGROUND AND OBJECTIVES: Hereditary hemorrhagic telangiectasia (HHT) is an inherited disease associated with pathogenic variants in transforming growth factor-β signaling pathway-related genes, resulting in abnormal vascular development in various organs. Brain arteriovenous malformations (AVMs) may lead to intracranial hemorrhage, and brain abscess or ischemic stroke may result from right to left shunting via pulmonary AVMs. We aimed to investigate the risk for these severe complications in both adults and children with HHT.

METHODS: We conducted a case-control study among participants aged 1-64 years in the MarketScan Commercial (2006-2019) and Multistate Medicaid Databases (2011-2019). We identified cases with HHT using

RESULTS: …

Peptidoglycan Deacetylation Controls Type Iv Secretion And The Intracellular Survival Of The Bacterial Pathogen Legionella Pneumophila, David Boamah, Michael C Gilmore, Sarah Bourget, Anushka Ghosh, Mohammad J Hossain, Joseph P Vogel, Felipe Cava, Tamara J O'Connor

2020-Current year OA Pubs

Peptidoglycan is a critical component of the bacteria cell envelope. Remodeling of the peptidoglycan is required for numerous essential cellular processes and has been linked to bacterial pathogenesis. Peptidoglycan deacetylases that remove the acetyl group of the

Achondroplasia Natural History Study (Clarity): 60-Year Experience In Orthopedic Surgery From Four Skeletal Dysplasia Centers, Nickolas J Nahm, W G Stuart Mackenzie, William G Mackenzie, Ethan Gough, S Shahrukh Hashmi, Jacqueline T Hecht, Janet M Legare, Mary Ellen Little, Peggy Modaff, Richard M Pauli, David F Rodriguez-Buritica, Maria Elena Serna, Cory J Smid, Julie Hoover-Fong, Michael B Bober

Faculty, Staff and Student Publications

BACKGROUND: The purpose of this study was to describe the frequency and risk factors for orthopedic surgery in patients with achondroplasia. CLARITY (The Achondroplasia Natural History Study) includes clinical data from achondroplasia patients receiving treatment at four skeletal dysplasia centers in the United States from 1957 to 2018. Data were entered and stored in a Research Electronic Data Capture (REDCap) database.

RESULTS: Information from one thousand three hundred and seventy-four patients with achondroplasia were included in this study. Four hundred and eight (29.7%) patients had at least one orthopedic surgery during their lifetime and 299 (21.8%) patients underwent multiple procedures. …

Achondroplasia Natural History Study (Clarity): 60-Year Experience In Orthopedic Surgery From Four Skeletal Dysplasia Centers, Nickolas J Nahm, W G Stuart Mackenzie, William G Mackenzie, Ethan Gough, S Shahrukh Hashmi, Jacqueline T Hecht, Janet M Legare, Mary Ellen Little, Peggy Modaff, Richard M Pauli, David F Rodriguez-Buritica, Maria Elena Serna, Cory J Smid, Julie Hoover-Fong, Michael B Bober

Faculty, Staff and Student Publications

BACKGROUND: The purpose of this study was to describe the frequency and risk factors for orthopedic surgery in patients with achondroplasia. CLARITY (The Achondroplasia Natural History Study) includes clinical data from achondroplasia patients receiving treatment at four skeletal dysplasia centers in the United States from 1957 to 2018. Data were entered and stored in a Research Electronic Data Capture (REDCap) database.

RESULTS: Information from one thousand three hundred and seventy-four patients with achondroplasia were included in this study. Four hundred and eight (29.7%) patients had at least one orthopedic surgery during their lifetime and 299 (21.8%) patients underwent multiple procedures. …

17Β-Estradiol Promotes Extracellular Vesicle Release And Selective Mirna Loading In Erα-Positive Breast Cancer, Rares Drula, Barbara Pardini, Xiao Fu, Mireia Cruz De Los Santos, Ancuta Jurj, Lan Pang, Sherien M El-Daly, Linda Fabris, Erik Knutsen, Mihnea P Dragomir, Recep Bayraktar, Yongfeng Li, Meng Chen, Filippo Del Vecchio, Léa Berland, Jessica Dae, Daniel Fan, Masayoshi Shimizu, Anh M Tran, Mercedes Barzi, Carlotta Pioppini, Angelica M Gutierrez, Cristina Ivan, Salyna Meas, Carolyn S Hall, Suresh K Alahari, Ioana Berindan-Neagoe, Muller Fabbri, Anthony Lucci, Banu Arun, Simone Anfossi, George A Calin

Faculty, Staff and Student Publications

The causes and consequences of abnormal biogenesis of extracellular vesicles (EVs) are not yet well understood in malignancies, including in breast cancers (BCs). Given the hormonal signaling dependence of estrogen receptor-positive (ER+) BC, we hypothesized that 17β-estradiol (estrogen) might influence EV production and microRNA (miRNA) loading. We report that physiological doses of 17β-estradiol promote EV secretion specifically from ER+ BC cells via inhibition of miR-149-5p, hindering its regulatory activity on SP1, a transcription factor that regulates the EV biogenesis factor nSMase2. Additionally, miR-149-5p downregulation promotes hnRNPA1 expression, responsible for the loading of let-7's miRNAs into EVs. In multiple patient cohorts, …

Optimization Of A Tidal–Wind–Solar System To Enhance Supply–Demand Balancing And Security: A Case Study Of The Goto Islands, Japan, Patxi Garcia-Novo, Daniel Coles, Yusaku Kyozuka, Reiko Yamada, Haruka Moriguchi, Daisaku Sakaguchi

School of Engineering, Computing and Mathematics

Due to the expected increase in electric power demand in the coming decades and the economic and environmental issues caused by power generation from the combustion of hydrocarbon fuels, the integration of renewable energy into the grids of remote islands has attracted attention. Among all renewable sources, tidal stream energy shows potential to contribute positively in areas with strong tidal currents due to the predictability and semi-diurnal periodicity of the resource, which makes it compatible with short-term energy storage. However, its performance in areas with lower available power density has not yet been addressed. In this paper, energy systems for …

Math Attitudes And Identity Of High Schoolers Impacted Through Participating In Informal, Near-Peer Mentoring, Aaron T. Wilson, Xiaohui Wang, Mayra Ortiz Galarza, John Knight, Eliazar Patiño

School of Mathematical & Statistical Sciences Faculty Publications

Research in mentoring has shown that students may at times be more willing and able to absorb information that is delivered to them by their near-peers, rather than by traditional figures of authority, like teachers and professors. In this study, underrepresented minority high school students participated in an informal learning experience that was led by college students who were "near-peers" to the high schoolers. Students were engaged by participating in interactive MathShows, following a Math Social Media Campaign, and attending a summer Math Internship. Participants in the quantitative component of the study included N = 559 U.S. high schoolers who …

Sb08-23/24: Resolution Revising Article Vii, Section 1 Of The Bylaws, Jordan Bailey

Senate Resolutions, 2007-Present

SB08-23/24: Resolution Revising Article VII, Section 1 of the Bylaws. This resolution passed 18Y-0N on a roll call vote during the October 4, 2023 meeting of the Associated Students of the University of Montana (ASUM).

Estimating Intermittency Significance By Means Of Surrogate Data: Implications For Solar Wind Turbulence, Eliza Teodorescu, Marius Mihai Echim, Jay Johnson

Faculty Publications

Introduction: Intermittency is a property of turbulent astrophysical plasmas, such as the solar wind, that implies irregularity and fragmentation, leading to non-uniformity in the transfer rate of energy carried by nonlinear structures from large to small scales. We evaluated the intermittency level of the turbulent magnetic field measured by the Parker Solar Probe (PSP) in the slow solar wind in the proximity of the Sun during the probe’s first close encounter. Methods: A quantitative measure of intermittency could be deduced from the normalized fourth-order moment of the probability distribution functions, the flatness parameter. We calculated the flatness of the magnetic …

Inequities In Treatments And Outcomes Among Patients Hospitalized With Hypertrophic Cardiomyopathy In The United States, Daniel Y Johnson, R J Waken, Daniel K Fox, Gmerice Hammond, Karen E Joynt Maddox, Sharon Cresci

2020-Current year OA Pubs

Background Hypertrophic cardiomyopathy (HCM) is the most common heritable cardiac disease. In small studies, sociodemographic factors have been associated with disparities in septal reduction therapy, but little is known about the association of sociodemographic factors with HCM treatments and outcomes more broadly. Methods and Results Using the National Inpatient Survey from 2012 to 2018, HCM diagnoses and procedures were identified by