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Articles 287641 - 287670 of 2921386
Full-Text Articles in Entire DC Network
Changes In Global Energy Landscape And New Developments In Energy Science And Technology Amid Ukraine Crisis, Chao Wang, Fuquan Sun, Ye Xu, Xiangqiang Jiang
Changes In Global Energy Landscape And New Developments In Energy Science And Technology Amid Ukraine Crisis, Chao Wang, Fuquan Sun, Ye Xu, Xiangqiang Jiang
Bulletin of Chinese Academy of Sciences (Chinese Version)
Energy is the blood vessel of an economy. The outbreak of the Ukraine crisis has triggered a regional energy supply crisis and a global energy market turmoil. As a result, the global energy landscape and energy science and technology development trends have undergone profound changes, with far-reaching impact on China’s science and technology strategies in the energy sector. Based on the study of energy strategy shift of the world’s major economies, this study focuses on research and analysis on the strategic trends of energy science and technology from the perspectives of international energy trade, global low-carbon transition and national energy …
Development And Issues Of Biotech Seed Industry In China, Peijuan Chi, Hualing Xie, Ping Zhao, Fang Chen, Ning Wu, Zhixi Tian, Weicai Yang, Yanping Yang
Development And Issues Of Biotech Seed Industry In China, Peijuan Chi, Hualing Xie, Ping Zhao, Fang Chen, Ning Wu, Zhixi Tian, Weicai Yang, Yanping Yang
Bulletin of Chinese Academy of Sciences (Chinese Version)
Biotech seed industry is a strategic core industry. Biotechnology combined with digital technology has promoted the seed industry into an intelligent era, and the breeding paradigm has changed from “experimental selection” to “computational selection”. Biotech seed industry has become a research and development intensive industry, and the market is highly concentrated, which is controlled by large multinational enterprises. The scientific and technological output of China and the United States is in the first echelon, and the number of papers and authorized patents ranks among the top two in the world. From the perspective of core competitiveness, the United States is …
Strengthening Open Data Infrastructure And Promoting Open Science, Huadong Guo, Hesheng Chen, Dongmei Yan, Jianhui Li, Gang Chen, Guojin He, Juncai Ma, Dong Liang, Lingyi Kong
Strengthening Open Data Infrastructure And Promoting Open Science, Huadong Guo, Hesheng Chen, Dongmei Yan, Jianhui Li, Gang Chen, Guojin He, Juncai Ma, Dong Liang, Lingyi Kong
Bulletin of Chinese Academy of Sciences (Chinese Version)
To promote economic development, social progress, and scientific and technological innovation, it is necessary to strengthen scientific cooperation and information sharing. Open data has emerged in response and become a seemingly inevitable development in the evolution of digital technology. Open data, however, must be supported by infrastructure composed of physical entities and virtual systems that meet the needs of data applications in many fields. Constructing and strengthening open data infrastructure should therefore be considered important objectives of information technology development. This study analyzes the elements of open data infrastructure and expounds its significant positive role in implementing open science. Based …
Changes In International Development Environment And China's Choices Of S&T Strategy: Historical Review And Future Prospects, Kaihua Chen, Zehua Xue, Chao Zhang
Changes In International Development Environment And China's Choices Of S&T Strategy: Historical Review And Future Prospects, Kaihua Chen, Zehua Xue, Chao Zhang
Bulletin of Chinese Academy of Sciences (Chinese Version)
Changes in international development environment such as geopolitics, geo-economics and science and technology innovation are reshaping the world’s competitive landscape and altering the balance of power among nations. China needs to adapt to the changes in international development environment, accurately grasp the new trends, optimize and adjust the science and technology strategy, effectively respond to new challenges, and seek new advantages in international competition. This study reviews China’s choices of science and technology strategy under the changes in international development environment. By summing up the successful experiences and remaining issues of the past science and technology strategies, the study proposes …
Research On Open Science Governance Framework Model, Yaxiang Yuan, Xin Wei, Yang Wang, Yuanchun Zhou
Research On Open Science Governance Framework Model, Yaxiang Yuan, Xin Wei, Yang Wang, Yuanchun Zhou
Bulletin of Chinese Academy of Sciences (Chinese Version)
Open science is thriving and driving a global paradigm shift in scientific research. Open science governance is designated to gradually increase the transparency and global participation in the process of scientific and technological progress, ensure low-cost openness around the world, accelerate the global dissemination and sharing of results, and improve the scientific and humanistic literacy of the people. With the development trend of open science becoming more and more powerful, a series of challenges emerge gradually. By analyzing and studying the open science governance framework model, it helps to further sort out the governance logic, clarify the governance subjects and …
Policy Overview (April—May, 2023)
Policy Overview (April—May, 2023)
Bulletin of Chinese Academy of Sciences (Chinese Version)
No abstract provided.
Cultivation Mode And Path Of Future Industries Driven By Disruptive Technologies — Enlightenment Of The United States’ Layout Of Next Generation Of Integrated Circuit Industry, Yue Zhang, Jiang Yu, Ya Yang, Feng Chen
Cultivation Mode And Path Of Future Industries Driven By Disruptive Technologies — Enlightenment Of The United States’ Layout Of Next Generation Of Integrated Circuit Industry, Yue Zhang, Jiang Yu, Ya Yang, Feng Chen
Bulletin of Chinese Academy of Sciences (Chinese Version)
Disruptive technologies have key impact on the path, direction, and international competition pattern of future industrial development, so the forward-looking layout of future industries driven by disruptive technologies is an inevitable choice for China to seize the commanding heights of science and technology and accelerate the construction of a new development pattern. Based on the in-depth analysis of the whole process and whole chain of the United States’ Electronics Resurgence Initiative layout of disruptive technologies and the technology identification mechanism, organization management mechanism, evaluation mechanism, and demonstration application mechanism of cultivating future industries, this study extracts the scientific connotation and …
Innovation Ecosystem Of Future Industry: Structure And Path, Junkai Li, Fei Gao, Yi Gong
Innovation Ecosystem Of Future Industry: Structure And Path, Junkai Li, Fei Gao, Yi Gong
Bulletin of Chinese Academy of Sciences (Chinese Version)
The innovation ecosystem of future industry faces great challenge in multiple dimensions such as systematic structure, function, and path for the continuous emergence and breakthrough of cutting-edge basic knowledge. Based on the theories of natural ecosystem and innovation system, this study builds a future industrial innovation ecosystem structure framework consisting of frontier knowledge creation community, application scenario transformation community, and industrial value realization community with consideration of the characteristics and evolution laws of future industry. In such innovation ecosystem, promising government and entrepreneurial spirit are important entity and key element, and policies for incubating and developing future industry should focus …
Ecological Governance Of Aral Sea: Important Way To Deepen Scientific And Technological Cooperation With Central Asia, Miao Wu, Jianfang Qiao, Yuanming Zhang, Changyan Tian, Yaoming Li, Yun Hao, Xiaoyun Zhang, Lixian Wang, Jingjing He
Ecological Governance Of Aral Sea: Important Way To Deepen Scientific And Technological Cooperation With Central Asia, Miao Wu, Jianfang Qiao, Yuanming Zhang, Changyan Tian, Yaoming Li, Yun Hao, Xiaoyun Zhang, Lixian Wang, Jingjing He
Bulletin of Chinese Academy of Sciences (Chinese Version)
In September 2022, the President of the People’s Republic of China visited Uzbekistan for the first time after the epidemic. In the subsequent joint statement between China and Uzbekistan, China welcomed the adoption of the Aral Sea initiative proposed by Uzbekistan at the General Assembly of the United Nations. The two sides expressed their willingness to actively promote synergy between the Global Development Initiative and projects related to improving the ecological, economic, and social environment of the Aral Sea region under the framework of the United Nations. In this context, this paper describes the current situation of the Aral Sea …
Some Trends And Enlightenment Of Darpa-Like Agencies In The United States, Jun Qiu, Zheng Liang, Xinyi Gu, Jianxiang Yuan, Lan Xue
Some Trends And Enlightenment Of Darpa-Like Agencies In The United States, Jun Qiu, Zheng Liang, Xinyi Gu, Jianxiang Yuan, Lan Xue
Bulletin of Chinese Academy of Sciences (Chinese Version)
In the context of major-power interactions, science and technology has increasingly become the main battleground and the inevitable place of competition among major powers. The new scientific and technological revolution will reshape the growth and decline of the economic competitiveness of countries and the global competition pattern. In order to compete for the increasingly competitive scientific and technological commanding heights, the United States clones the successful Defense Advanced Research Projects Agency (DARPA), which has been active and achieved many scientific and technological innovation achievements. Now, the United States plans to promote the establishment of agencies, such as the Advanced Research …
Strengthen Basic Research Capacity Of Enterprises And Make Up For Shortcoming Of National Innovation System, Xielin Liu, Xinzhi Chang, Peipei Yang
Strengthen Basic Research Capacity Of Enterprises And Make Up For Shortcoming Of National Innovation System, Xielin Liu, Xinzhi Chang, Peipei Yang
Bulletin of Chinese Academy of Sciences (Chinese Version)
Basic research is the source of technological innovation, and currently, public research entities are the main force behind basic research. However, demand-driven research in the Pasteur quadrant and Edison quadrant requires firms to play a major role. The experience of the United States has shown that large firms can directly bridge the gap between science and industrial demand, improve industrial competitiveness, and the key lies in improving their scientific capabilities. Encouraging large firms to invest in demand-driven basic research can accelerate the transfer and transformation of scientific and technological achievements, increase the industrialization of basic research, and fill the demand-side …
Research On China’S Open Science Policy System, Wei Yang, Xiwen Liu, Jinxia Huang, Man Xiao, Xinman Zheng, Ruofei Chang
Research On China’S Open Science Policy System, Wei Yang, Xiwen Liu, Jinxia Huang, Man Xiao, Xinman Zheng, Ruofei Chang
Bulletin of Chinese Academy of Sciences (Chinese Version)
Open science has risen to the global strategic level. The open science policy will provide an accelerator for achieving global sustainable development goals. China’s formulation and support of open access policies and open science infrastructure policies are still insufficient. The practical demand for China’s open science policy comes from the emerging open innovation research scenario, while the long- term demand comes from the construction of an open innovation ecosystem. This study proposes an open science policy system that conforms to the framework of China’s science and technology innovation policy system, and proposes policy action suggestions that adapt to the UNESCO …
Trend Observation: Analysis On Development Trend Of Precision Medicine
Trend Observation: Analysis On Development Trend Of Precision Medicine
Bulletin of Chinese Academy of Sciences (Chinese Version)
No abstract provided.
Majority In Nh Think Trump Committed A Crime In Mishandled Docs Case, Half Believe He Will Be Convicted 6/20/2023, Unh Survey Center
Majority In Nh Think Trump Committed A Crime In Mishandled Docs Case, Half Believe He Will Be Convicted 6/20/2023, Unh Survey Center
All UNH Survey Center Polls
Six in ten New Hampshire residents believe Donald Trump committed a crime in the federal investigation into mishandling of classified documents and half think he will be convicted. However, very few 2020 Trump voters say his indictment makes them less likely to vote for him. On other topics, an increasing percentage of Granite Staters think the U.S. is doing too much to aid Ukraine and few expect an outright Ukrainian victory. Ahead of a Supreme Court decision, a majority of Granite Staters disapprove of colleges and universities using race and ethnicity in their admissions decisions.
Linear And Nonlinear Optical Properties Of Anthocyanin Dye From Red Cabbage In Different Ph Solutions, Rajaa Nader, Slafa I. Ibrahim Ibrahim, Ali H. Al-Hamdani
Linear And Nonlinear Optical Properties Of Anthocyanin Dye From Red Cabbage In Different Ph Solutions, Rajaa Nader, Slafa I. Ibrahim Ibrahim, Ali H. Al-Hamdani
Baghdad Science Journal
This article studied some linear and nonlinear optical characteristics of different pH solutions from anthocyanin dye extract at 180 oC from red cabbage. First, the linear spectral characteristics, including absorption and transmittance in the range 400-800 nm for anthocyanin solution 5% v/v with different pHs, were achieved utilizing a UV/VIS spectrophotometer. The experimental results reveal a shift in the absorption toward the longer wavelength direction as pH values increment. Then, the nonlinear features were measured using the Z-scan technique with a CW 532 nm laser to measure the nonlinear absorption coefficient through an open aperture. A close aperture (diameter 2 …
Delay Differential Equation Of The 2nd Order And It's An Oscillation Yardstick, Anmar Hashim Jasim
Delay Differential Equation Of The 2nd Order And It's An Oscillation Yardstick, Anmar Hashim Jasim
Baghdad Science Journal
This study focuses on studying an oscillation of a second-order delay differential equation. Start work, the equation is introduced here with adequate provisions. All the previous is braced by theorems and examplesthat interpret the applicability and the firmness of the acquired provisions
Evaluation Of Serum Levels Of Proinflammatory Cytokines Il-8, Il-17, And Il-22 In Helicobacter Pylori Infection And Their Association With The Degree Of Gastritis Histopathology In A Sample Of Iraqi Patients, Miriam Jasim Shehab, Batool Mutar Mahdi, Reem Husam Al-Tabra, Dhuha Salim Namaa
Evaluation Of Serum Levels Of Proinflammatory Cytokines Il-8, Il-17, And Il-22 In Helicobacter Pylori Infection And Their Association With The Degree Of Gastritis Histopathology In A Sample Of Iraqi Patients, Miriam Jasim Shehab, Batool Mutar Mahdi, Reem Husam Al-Tabra, Dhuha Salim Namaa
Baghdad Science Journal
Gastritis can be defined as histological inflammation of the gastric mucosa. It can be classified according to the time course of the disease as acute or chronic, histological findings, anatomic location, and pathological mechanisms. The objective of this study was to evaluation of serum levels of the proinflammatory cytokines IL-8, IL-17 and IL-22 in Helicobacter pylori infection and their association with the degree of gastritis histopathology in a sample of Iraqi patients. The case-control prospective study consists of 60 patients who attended the Gastrointestinal Tract Center at Al-Kindy Teaching Hospital during the period from December 2019 to April 2020. In …
Dynamic Simulation Of Urban Agglomeration Passenger Transport Network Vulnerability Based On Multi-Agent, Chengbing Li, Yunfei Li, Peng Wu
Dynamic Simulation Of Urban Agglomeration Passenger Transport Network Vulnerability Based On Multi-Agent, Chengbing Li, Yunfei Li, Peng Wu
Journal of System Simulation
Research on vulnerability of comprehensive passenger transportation network in urban agglomerations helps to ensure the transportation efficiency of intercity travel.A comprehensive passenger transport network model of urban agglomeration is built based on multi-layer complex network theory. Urban transportation transfer factors are considered, actual passenger flow is used to calibrate the station load and capacity and a dynamic model of network cascading failure is constructed. Multi-agents are used to simulate the actual passenger flow, Dijkstra algorithm is used to find the shortest path, and two time-dimensional vulnerability evaluation indicators are proposed.MATLAB is used to carry out the dynamic simulation …
Comparative Outcomes Of Interventions For Femoropopliteal Chronic Total Occlusion Versus Non-Chronic Total Occlusion Lesions From The Multicenter Xlpad Registry, Shirling Tsai, Yulun Liu, Lawrence Hoang, Michael Vu, Hua Lu, Bala Ramanan, David Fernandez Vazquez, Zachary Rosol, Sameh Sayfo, Mohamad Amer Alaiti, Panagiotis Koutakis, Emmanouil S Brilakis, Mehdi H Shishehbor, Subhash Banerjee
Comparative Outcomes Of Interventions For Femoropopliteal Chronic Total Occlusion Versus Non-Chronic Total Occlusion Lesions From The Multicenter Xlpad Registry, Shirling Tsai, Yulun Liu, Lawrence Hoang, Michael Vu, Hua Lu, Bala Ramanan, David Fernandez Vazquez, Zachary Rosol, Sameh Sayfo, Mohamad Amer Alaiti, Panagiotis Koutakis, Emmanouil S Brilakis, Mehdi H Shishehbor, Subhash Banerjee
Faculty, Staff and Student Publications
Background Endovascular intervention of femoropopliteal chronic total occlusions (CTOs) is technically more complex. However, there is lack of comparative analysis between CTO and non-CTO femoropopliteal interventions. Methods and Results We report procedural details and outcomes of patients treated for femoropopliteal CTO and non-CTO lesions in the XLPAD (Excellence in Peripheral Artery Disease) registry (NCT01904851) between 2006 and 2019. Primary outcomes were procedural success and 1-year major adverse limb events, a composite of all-cause death, target limb revascularization, or major amputation. Analysis included 2895 patients (CTO: n=1516 patients; non-CTO: n=1379 patients) with 3658 lesions (CTO: n=1998 lesions; non-CTO: n=1660 lesions). Conventional …
Continuous Professional Development And Work Conditions For English-Language Teaching Practitioners In Ireland: Where Do We Go From Here?, Deborah Tobin, Cathryn Bennett
Continuous Professional Development And Work Conditions For English-Language Teaching Practitioners In Ireland: Where Do We Go From Here?, Deborah Tobin, Cathryn Bennett
Irish Journal of Academic Practice
In Ireland, English-language schools have historically constituted a lucrative sector for their owners and the Irish exchequer. However, teachers of English as a foreign language have not reaped financial rewards on an equitable scale. Two online surveys were conducted in 2020 and 2021 to ascertain teachers’ attitudes to continuous professional development and to their workplace conditions in privately-run schools. Findings from both surveys reflect a highly skilled, highly qualified and highly motivated cohort with a strong commitment to engaging in continuous professional development and a keen sense of their own professionalism. However, this was not found to be reflected in …
Complete Genome Sequences Of 37 Bacteria From The Human Vaginal Tract, Christopher Whidbey, Alyssa N Konopaski, Robel Teshome, Sejal Dhaliwal, M Quinn Peters, Marlyd E Mejia, Mallory B Ballard, Kathryn A Patras
Complete Genome Sequences Of 37 Bacteria From The Human Vaginal Tract, Christopher Whidbey, Alyssa N Konopaski, Robel Teshome, Sejal Dhaliwal, M Quinn Peters, Marlyd E Mejia, Mallory B Ballard, Kathryn A Patras
Faculty, Staff and Students Publications
Microorganisms colonizing the human vaginal mucosa are associated with healthy states, as well as conditions such as bacterial vaginosis and infection-associated preterm birth. Here, we report complete genome sequences of 37 bacterial isolates from the human vaginal tract.
Further Refinement Of An Asd-Subscale For The Childhood Behavior Checklist, Kimberly Ellison
Further Refinement Of An Asd-Subscale For The Childhood Behavior Checklist, Kimberly Ellison
LSU Doctoral Dissertations
The early diagnosis of autism spectrum disorder (ASD) is tied to receiving the earliest possible intervention services that can influence a child’s development (Filipek et al., 1999). There are different measurement tools utilized to aid in the diagnostic assessment process, including broadband behavioral rating scales. The Childhood Behavior Checklist (CBCL; Achenbach & Rescorla, 2001) is a parent/caregiver completed questionnaire about one’s child (typically or atypically developing). The CBCL is one of the most utilized broadband measures at the initial stages of a diagnostic assessment or screening to aid in understanding the symptom presentation (Hyman et al., 2020). Currently, there …
Striatal Dopamine Synthesis And Cognitive Flexibility Differ Between Hormonal Contraceptive Users And Nonusers, Caitlin M Taylor, Daniella J Furman, Anne S Berry, Robert L White, William J Jagust, Mark D'Esposito, Emily G Jacobs
Striatal Dopamine Synthesis And Cognitive Flexibility Differ Between Hormonal Contraceptive Users And Nonusers, Caitlin M Taylor, Daniella J Furman, Anne S Berry, Robert L White, William J Jagust, Mark D'Esposito, Emily G Jacobs
2020-Current year OA Pubs
In rodents and nonhuman primates, sex hormones are powerful modulators of dopamine (DA) neurotransmission. Yet less is known about hormonal regulation of the DA system in the human brain. Using positron emission tomography (PET), we address this gap by comparing hormonal contraceptive users and nonusers across multiple aspects of DA function: DA synthesis capacity via the PET radioligand 6-[18F]fluoro-m-tyrosine ([18F]FMT), baseline D2/3 receptor binding potential using [11C]raclopride, and DA release using methylphenidate-paired [11C]raclopride. Participants consisted of 36 healthy women (n = 15 hormonal contraceptive users; n = 21 naturally cycling/non users of hormonal contraception), and men (n = 20) as …
Robust Acoustic Trapping And Perturbation Of Single-Cell Microswimmers Illuminate Three-Dimensional Swimming And Ciliary Coordination, Mingyang Cui, Susan K Dutcher, Philip V Bayly, J Mark Meacham
Robust Acoustic Trapping And Perturbation Of Single-Cell Microswimmers Illuminate Three-Dimensional Swimming And Ciliary Coordination, Mingyang Cui, Susan K Dutcher, Philip V Bayly, J Mark Meacham
2020-Current year OA Pubs
We report a label-free acoustic microfluidic method to confine single, cilia-driven swimming cells in space without limiting their rotational degrees of freedom. Our platform integrates a surface acoustic wave (SAW) actuator and bulk acoustic wave (BAW) trapping array to enable multiplexed analysis with high spatial resolution and trapping forces that are strong enough to hold individual microswimmers. The hybrid BAW/SAW acoustic tweezers employ high-efficiency mode conversion to achieve submicron image resolution while compensating for parasitic system losses to immersion oil in contact with the microfluidic chip. We use the platform to quantify cilia and cell body motion for wildtype biciliate …
The Effects Of Integral And Incidental Emotions On The Perceived Risk Of Gun Violence, Gloria Laugalis
The Effects Of Integral And Incidental Emotions On The Perceived Risk Of Gun Violence, Gloria Laugalis
USF Tampa Graduate Theses and Dissertations
Fearful people are pessimistic when it comes to risk judgments and angry people areoptimistic in their risk judgments (Lerner & Keltner, 2000; 2001). Since this has been supported in studies regarding both incidental and integral emotions, the findings from incidental studies have been broadly generalized to answer research questions regarding integral emotions. This generalization was challenged when Ferrer and Ellis (2021) recently found differing effects of incidental and integral emotions of fear and anger. In this study, we examine the effects of these emotions, both incidental and integral to the target risk, on risk perception to help determine if incidental …
Academic Procrastination Among Chinese International Undergraduate Students In The United States, Yunlu Xiang
Academic Procrastination Among Chinese International Undergraduate Students In The United States, Yunlu Xiang
USF Tampa Graduate Theses and Dissertations
This research aimed to explore academic procrastination among Chinese internationalstudents, using NVivo 12 to analyze data gathered through interviews with six participants. The study identified both internal and external factors contributing to academic procrastination, with social networking and software being the most significant external factors and disinterest and avoidance being the most significant internal factors. The participants did not identify the COVID-19 pandemic as a significant factor in academic procrastination. The study analyzed gender differences in academic procrastination among Chinese students. The pandemic had different effects on men and women, with men downplaying the concept of time and women experiencing …
Long-Term Outcomes And Molecular Correlates Of Sotorasib Efficacy In Patients With Pretreated Kras G12c-Mutated Non–Small-Cell Lung Cancer: 2-Year Analysis Of Codebreak 100, Grace K Dy, Ramaswamy Govindan, Vamsidhar Velcheti, Gerald S Falchook, Antoine Italiano, Jürgen Wolf, Adrian G Sacher, Toshiaki Takahashi, Suresh S Ramalingam, Christophe Dooms, Dong-Wan Kim, Alfredo Addeo, Jayesh Desai, Martin Schuler, Pascale Tomasini, David S Hong, Piro Lito, Qui Tran, Simon Jones, Abraham Anderson, Antreas Hindoyan, Wendy Snyder, Ferdinandos Skoulidis, Bob T Li
Long-Term Outcomes And Molecular Correlates Of Sotorasib Efficacy In Patients With Pretreated Kras G12c-Mutated Non–Small-Cell Lung Cancer: 2-Year Analysis Of Codebreak 100, Grace K Dy, Ramaswamy Govindan, Vamsidhar Velcheti, Gerald S Falchook, Antoine Italiano, Jürgen Wolf, Adrian G Sacher, Toshiaki Takahashi, Suresh S Ramalingam, Christophe Dooms, Dong-Wan Kim, Alfredo Addeo, Jayesh Desai, Martin Schuler, Pascale Tomasini, David S Hong, Piro Lito, Qui Tran, Simon Jones, Abraham Anderson, Antreas Hindoyan, Wendy Snyder, Ferdinandos Skoulidis, Bob T Li
Faculty, Staff and Student Publications
Clinical trials frequently include multiple end points that mature at different times. The initial report, typically based on the primary end point, may be published when key planned co-primary or secondary analyses are not yet available. Clinical Trial Updates provide an opportunity to disseminate additional results from studies, published in JCO or elsewhere, for which the primary end point has already been reported.
In the longest follow-up, to our knowledge, for a KRASG12C inhibitor, we assessed the long-term efficacy, safety, and biomarkers of sotorasib in patients with KRAS G12C-mutated advanced non–small-cell lung cancer (NSCLC) from the CodeBreaK 100 clinical …
Arginine Depletion Attenuates Renal Cystogenesis In Tuberous Sclerosis Complex Model, Athar Amleh, Hadass Pri Chen, Lana Watad, Ifat Abramovich, Bella Agranovich, Eyal Gottlieb, Iddo Z Ben-Dov, Morris Nechama, Oded Volovelsky
Arginine Depletion Attenuates Renal Cystogenesis In Tuberous Sclerosis Complex Model, Athar Amleh, Hadass Pri Chen, Lana Watad, Ifat Abramovich, Bella Agranovich, Eyal Gottlieb, Iddo Z Ben-Dov, Morris Nechama, Oded Volovelsky
Faculty, Staff and Student Publications
Cystic kidney disease is a leading cause of morbidity in patients with tuberous sclerosis complex (TSC). We characterize the misregulated metabolic pathways using cell lines, a TSC mouse model, and human kidney sections. Our study reveals a substantial perturbation in the arginine biosynthesis pathway in TSC models with overexpression of argininosuccinate synthetase 1 (ASS1). The rise in ASS1 expression is dependent on the mechanistic target of rapamycin complex 1 (mTORC1) activity. Arginine depletion prevents mTORC1 hyperactivation and cell cycle progression and averts cystogenic signaling overexpression of c-Myc and P65. Accordingly, an arginine-depleted diet substantially reduces the TSC cystic load in …
Symplectic Lattice Gauge Theories On Grid: Approaching The Conformal Window, E Bennett, Pa Boyle, Debbio L Del, N Forzano, Dk Hong, J-W Lee, J Lenz, C-Jd Lin, B Lucini, A Lupo, M Piai, D Vadacchino
Symplectic Lattice Gauge Theories On Grid: Approaching The Conformal Window, E Bennett, Pa Boyle, Debbio L Del, N Forzano, Dk Hong, J-W Lee, J Lenz, C-Jd Lin, B Lucini, A Lupo, M Piai, D Vadacchino
School of Engineering, Computing and Mathematics
No abstract provided.