Digital Commons Network^™

Harvestable Metadata Services Development: Analysis Of Use Cases From The World Data System, Robert R. Downs, Alicia Urquidi Díaz, Qi Xu, Juanle Wang, Aude Chambodut, Chuang Liu, Simon Flower, Karen Payne

Copyright, Fair Use, Scholarly Communication, etc.

Minimally, a research data repository exists to make a collection of data assets available to potential users. If a dataset cannot be discovered and found, it cannot be reused (Garnett et al. 2017). Harvestable metadata catalogues are a key strategy for achieving greater global findability of data assets, as they create a surveyable access point to discover data products within large data collections. Such catalogues can be especially effective if they are tailored for interoperability with feature-rich infrastructures (e.g. meta-catalogues, see Kapiszewski & Karcher 2020; CRFCB 2014) that are highly visible and widely used, and also themselves integrated within the …

The Parthenon, July 5, 2023, Evan Green, Conner Woodruff, Matt Schaffer, Chayce Matheny, Victoria Ware, Shauntelle Thompson, Rafael Alfonso, Scott Price

The Parthenon

No abstract provided.

Regulation Of Nucleotide Excision Repair, Wenzhi Gong

LSU Doctoral Dissertations

Nucleotide excision repair (NER), a “cut and patch” mechanism, has two subpathways, namely transcription coupled repair (TCR) and global genome repair (GGR). TCR rapidly removes UV photoproduct (UV PP) in the transcribed strand (TS) of an actively transcribed gene, whereas GGR removes those DNA lesions throughout the genome. This dissertation mainly focused on identifying novel factors that function in NER and investigating the potential molecular mechanisms underlying initial damage recognition and downstream processes in NER. We identified Rpb7, a subunit of RNA polymerase II, represses TCR via its multiple regions. Specifically, the conserved region of Rpb7 that interacts with the …

Expressing Outrage, Re-Inventing Hope: Performing Nationhood In Nigerian Standup Comedy., Babasinmisola Fadirepo

LSU Doctoral Dissertations

The intersection of the Nigerian national identity and popular culture has been overwhelmingly located in the Nigerian movie industry and the Afrobeats, the flourishing Nigerian popular music. Further, when intervention about the Nigerian national identity is located within standup comedy performances, such analysis is vastly linguistic analysis of the performance. Through the lens of performance studies, this dissertation extends the discussion of the Nigerian national identity to standup comedy performances. In addition to the linguistic analysis of select Nigerian standup comedy performances, this work considers the location, costumes of comic acts, and the settings of the performance studied. Simply, this …

Circadian Disruption And Colorectal Cancer Incidence In Black Women, Lauren E Barber, Trang Vopham, Laura F White, Hemant K Roy, Julie R Palmer, Kimberly A Bertrand

Faculty, Staff and Students Publications

BACKGROUND: Animal and experimental studies suggest circadian disruption increases colorectal cancer risk, but evidence in humans is limited. We examined night shift work, chronotype, and residential position within a time zone, proxies for circadian disruption, in relation to colorectal cancer risk.

METHODS: Participants in the Black Women's Health Study, a prospective cohort of 59,000 Black American women established in 1995, reported history of night shift work and chronotype on follow-up questionnaires. Residential position within a time zone was estimated using participant addresses at each questionnaire cycle. Number of colorectal cancer cases and follow-up duration varied by analysis depending on timing …

Feasibility And Safety Of Personalized, Multi-Target, Adoptive Cell Therapy (Ima101): First-In-Human Clinical Trial In Patients With Advanced Metastatic Cancer, Apostolia M Tsimberidou, Kerstin Guenther, Borje S Andersson, Regina Mendrzyk, Amir Alpert, Claudia Wagner, Anna Nowak, Katrin Aslan, Arun Satelli, Fabian Richter, Sabrina Kuttruff-Coqui, Oliver Schoor, Jens Fritsche, Zoe Coughlin, Ali S Mohamed, Kerry Sieger, Becky Norris, Rita Ort, Jennifer Beck, Henry Hiep Vo, Franziska Hoffgaard, Manuel Ruh, Linus Backert, Ignacio I Wistuba, David Fuhrmann, Nuhad K Ibrahim, Van Karlyle Morris, Bryan K Kee, Daniel M Halperin, Graciela M Nogueras-Gonzalez, Partow Kebriaei, Elizabeth J Shpall, David Vining, Patrick Hwu, Harpreet Singh, Carsten Reinhardt, Cedrik M Britten, Norbert Hilf, Toni Weinschenk, Dominik Maurer, Steffen Walter

Faculty, Staff and Student Publications

IMA101 is an actively personalized, multi-targeted adoptive cell therapy (ACT), whereby autologous T cells are directed against multiple novel defined peptide-HLA (pHLA) cancer targets. HLA-A*02:01-positive patients with relapsed/refractory solid tumors expressing ≥1 of 8 predefined targets underwent leukapheresis. Endogenous T cells specific for up to 4 targets were primed and expanded in vitro. Patients received lymphodepletion (fludarabine, cyclophosphamide), followed by T-cell infusion and low-dose IL2 (Cohort 1). Patients in Cohort 2 received atezolizumab for up to 1 year (NCT02876510). Overall, 214 patients were screened, 15 received lymphodepletion (13 women, 2 men; median age, 44 years), and 14 were treated with …

Phase Ii Trial Of Medi0457 And Durvalumab For Patients With Recurrent/Metastatic Human Papillomavirus-Associated Cancers, Van K Morris, Amir Jazaeri, Shannon N Westin, Curtis Pettaway, Solly George, Ryan W Huey, Michaela Grinsfelder, Aaron Shafer, Benny Johnson, David Vining, Ming Guo, Bryan Fellman, Michael Frumovitz

Faculty, Staff and Student Publications

BACKGROUND: Human papillomavirus (HPV) types 16/18 drive oncogenesis for most patients with cervical, anal, and penile cancers. MEDI0457, a therapeutic DNA vaccine containing plasmids for E6 and E7 HPV-16/18 viral oncogenes and IL-12 adjuvant, is safe and provokes an immune response against E6/E7. We tested MEDI0457 with the anti-PD-L1 antibody durvalumab for patients with HPV-associated cancers.

METHODS: Patients with recurrent/metastatic, treatment-refractory HPV-16/18 cervical cancer, or rare HPV-associated (anal and penile) cancers were eligible. Prior immune checkpoint inhibition was not permitted. Patients received MEDI0457 7 mg intramuscularly (weeks 1, 3, 7, 12, and every 8 weeks thereafter) and durvalumab 1500 mg …

“An All-Inclusive, User-Friendly Resource”: A Review Of Taylor, Bogdan, And Devault’S Introduction To Qualitative Research Methods: A Guidebook And Resource (4th Edition), Mohammed Worku, Haymanot Alemayehu, Leta Ashebir, Kenenisa Lemi Debela Dr.

The Qualitative Report

We reviewed Taylor, Bogdan, and DeVault’s book entitled, Introduction to Qualitative Research Methods: A Guidebook and Resource (4th ed., 2016), and found to be an all-inclusive guide, user-friendly, and resourceful for qualitative researchers. Its inclusion of selected studies as examples to align them with the narratives of the main body of the study makes its value greater.

The Strategies Of Post-Covid Age In Iranian Higher Education: A Qualitative Approach, Esmaiel Jafari

The Qualitative Report

In the present study, the strategies of Iranian Higher Education Institutions (HEIs) in the post-COVID era have been considered. The research approach is qualitative and phenomenological, and accordingly, semi-structured interviews were conducted with 19 samples from two groups of chief executive officer and faculty members. Thematic content analysis method was used to analyze the qualitative data. The results showed that the strategies and guidelines of the higher education system in the post-COVID era include (1) Facilitate and promote domestic and international cooperation, (2) Attracting public support (3) Use of various teaching methods and (4) Develop the competencies of the faculty …

Infusing Military Culture In Multicultural Counseling Frameworks: A Phenomenological Study, Katherine M. Atkins, Toni R. Tollerud, Tilottama Roy-White, Lauren E. Brdecka, Deanna Chrones

The Qualitative Report

This descriptive phenomenological study focused on counselor educators’ (CESs) experiences infusing military culture into counseling curriculum. Specifically, this study sought to learn what counseling programs can do to best prepare counselors-in-training to work with military families. The researchers used the McCracken (1988) method to interview ten participants who had terminal degrees in counselor education or a highly related field, experience providing services to military-connected clients, and were aware of military cultural facets (e.g., implicit and explicit expectations, rules, and ways of being). The findings support the need to redefine multiculturalism and intentional infusion of military culture in counseling curriculum to …

Patient's Perspective Of Shared Decision-Making In Rheumatoid Arthritis Treatment: A Grounded Theory Exploration, Isabela Viana Oliveira, Mariana Martins Gonzaga Nascimento, Cristiane P. Rezende Mrs, Carina M. Neves, Hagabo Mathyell Silva, Ana Luiza Mourawad Cesar, Djenane Ramalho De Oliveira

The Qualitative Report

Current guidelines for rheumatoid arthritis (RA) treatment state that all decisions should be shared with the patient. Therefore, it becomes necessary to understand in-depth how patients with RA with different levels of health literacy and activation feel about sharing the decision with the health professional and how they experience this process. Grounded theory was used. Data collection included semi-structured interviews with 14 patients with RA. From the analysis of the patients’ narratives, four categories were built: “Accepting the changes: non-shared decisions”; “The patient's rationale: why not share?”; “Reaching the requirements for sharing the decision: expanding the patient’s autonomy"; and "Experiencing …

The Significance Of Executive Protection In Collaborative Crisis Management Planning, Alan Saquella

Publications

In today’s dynamic and unpredictable business landscape, organizations face numerous potential crises that can disrupt operations and damage their reputation. To effectively mitigate the adverse impact of such events, organizations must consider executive protection as a crucial component of their crisis management planning. This article emphasizes the importance of collaborative crisis management planning, highlighting the critical role of executive protection in ensuring business continuity.

Optimizing The Membrane-Assisted Recovery Of Solids (Mars) Technology For Nutrient Removal And Recovery From Concentrated Waste Streams, Ben Yamin Hoque

USF Tampa Graduate Theses and Dissertations

The effective management of nutrients, such as nitrogen and phosphorus, in decentralizedwastewater treatment environments is a pressing challenge. These nutrients pose significant risks to the environment and public health when discharged into water bodies, while their recovery and reuse can help alleviate nutrient shortages in various industries, including agriculture. Conventional biological treatment methods used in centralized facilities are not suitable for decentralized systems due to operational complexities and space limitations. Chemical treatment mechanisms, such as adsorption, ion exchange, precipitation, and air-stripping, offer potential solutions but are accompanied by challenges like high costs and logistical issues. Therefore, finding a sustainable and …

The Association Between Reintegration, Perceptions Of Health And Flourishing During Transition From Military To Civilian Life Among Veterans With Invisible Injuries, Nicholas Rattray, Mindy Flanagan, Michelle Salyers, Diana Natividad, Ai-Nghia Do, Richard Frankel, Katrina Spontak, Marina Kukla

Health Services and Informatics Research

Veterans with mental health or cognitive conditions who are separating from military service often face challenges transitioning to civilian life. However, questions remain about the relationship between reintegration and key psychosocial and well-being outcomes for veteran populations with invisible injuries soon after military separation. We investigated cross-sectional relationships between reintegration difficulties and health and well-being outcomes based on data from standardized measures with 75 US veterans. Reintegration difficulties were associated with low mental health functioning, lower social support, and lower flourishing. Reporting fewer perceived limitations with reintegration was positively associated with physical functioning, and higher levels of participation were positively …

Elementary Teachers' Perspectives On Teaching Reading Comprehension, Reid Smith, Pamela Snow, Tanya Serry, Lorraine Hammond

Research outputs 2022 to 2026

PURPOSE: We report findings from a survey of elementary teachers regarding reading instruction. The purpose was to examine teachers' beliefs about how children in the first 7 years of schooling develop reading comprehension skills and to characterize the self-reported practices and strategies they use to support children to comprehend connected text. METHOD: A web-based survey was used to collect data from 284 Australian elementary teachers about their beliefs and practices regarding reading comprehension instruction. Selected Likert-scale items were aggregated to determine the degree to which participants held "child-centered" or "content-centered" views of reading instruction. RESULTS: Australian elementary school teachers hold …

Office Of Research, Economic Engagement And Outreach Update, July 5, 2023, Office Of Research, Economic Engagement And Outreach

Office of Research, Economic Engagement and Outreach

No abstract provided.

Experimental Investigation Of Polymer Injection In High Permeability Conduits For Material Sustainability And Behavior In Oil Reservoirs, Sherif Fakher, Abdelaziz Lafi Khlaifat

Faculty Journal Articles

No abstract provided.

Tiam1 Coordinates Synaptic Structural And Functional Plasticity Underpinning The Pathophysiology Of Neuropathic Pain, Lingyong Li, Qin Ru, Yungang Lu, Xing Fang, Guanxing Chen, Ali Bin Saifullah, Changqun Yao, Kimberley F Tolias

Faculty, Staff and Students Publications

Neuropathic pain is a common, debilitating chronic pain condition caused by damage or a disease affecting the somatosensory nervous system. Understanding the pathophysiological mechanisms underlying neuropathic pain is critical for developing new therapeutic strategies to treat chronic pain effectively. Tiam1 is a Rac1 guanine nucleotide exchange factor (GEF) that promotes dendritic and synaptic growth during hippocampal development by inducing actin cytoskeletal remodeling. Here, using multiple neuropathic pain animal models, we show that Tiam1 coordinates synaptic structural and functional plasticity in the spinal dorsal horn via actin cytoskeleton reorganization and synaptic NMDAR stabilization and that these actions are essential for the …

You Ca N’T Police Your Way Out Of These Problems: Disregarding The Structural Components Of Community Problems, Kian Spencer Gaines

Theses and Dissertations

Community-Oriented Policing Services (COPS) emerged in response to longstanding criticisms revolving around police accountability and effectiveness. It emphasizes civilian participation in crime-prevention and problem-solving efforts to build trust between the police and minoritized communities with whom they have had an antagonistic relationship. Traditional policing is reactive in nature, with officers acting only after crime has been committed or a call for service has been made; it enforces the law; “legitimizes” use of violence; and emulates military structure and tactics. In this study I describe it as “enforcement” or “crime-fighting policing.” COPS programs are embedded within this structure. Unlike traditional policing, …

Brain Structure Correlates Of Obsessive-Compulsive Personality Traits, Allison Moreau

Arts & Sciences Graduate Student Theses and Dissertations

Obsessive-Compulsive Personality Disorder (OCPD) is the most common personality disorder, yet much remains unknown about its etiology. Although neural contributions to many other psychiatric disorders have been extensively studied, few existing studies have examined neural correlates of OCPD. Furthermore, all have had insufficient sample sizes to produce reliable results. Large samples are needed to reliably detect the expected small brain-behavior relationships. However, large neuroimaging studies often do not assess for personality disorders, although many assess for normative personality. The present study employed a Five-Factor Model of personality disorders, which conceptualizes personality disorders as maladaptive extremes of normative personality traits, to …

Fatal Crashes Rose In Alabama Over Past 3 Years, New Uab Study Finds, Matt Windsor

Browse All News

No abstract provided.

How To Protect Yourself From Travel Scams, Tehreem Khan

Browse All News

No abstract provided.

Evaluating The Generalizability Of Predictive Classifiers Built From Desi Imaging Lipid Data Across Mass Spectrometry Platformsjournal Of The American Society For Mass Spectrometry, Rachel J Dehoog, Monica Lin, Gregory Roman, Roy Martin, James Suliburk, Livia S Eberlin

Faculty, Staff and Students Publications

In this study, we evaluate the generalizability of predictive classifiers built from DESI lipid data for thyroid fine needle aspiration (FNA) biopsy analysis and classification using two high-performance mass spectrometers (time-of-flight and orbitrap) suited with different DESI imaging sources operated by different users. The molecular profiles obtained from thyroid samples with the different platforms presented similar trends, although specific differences in ion abundances were observed. When using a previously published statistical model built to discriminate thyroid cancer from benign thyroid tissues to predict on a new independent data set obtained, agreement for 24 of the 30 samples across the imaging …

An Undesired Implication From Globalization: Isis, An Adaptive Threat In A Dormant Phase, Abel Josafat Manullang, Raden Ap Wicaksono, Arfin Sudirman

Global: Jurnal Politik Internasional

Globalization has brought about numerous changes to the world. However, those changes and advances have also been enjoyed by terrorist groups, one of them is ISIS which uses those things in its terror acts. This article seeks to explain how ISIS has adapted and enhanced its capacity as a result of globalization. Apart from employing the qualitative research method, this article also uses concepts and theories like terrorism, globalization, and James D. Kiras's theory on how globalization enhances terrorism. This article would then proceed to the three matters of ISIS as a threat to national and international security, how ISIS …

Asean’S Role In The Regional Comprehensive Economic Partnership (Rcep) Formation To Enhance Regional Economic Integration, Shofiya Adila, Dadan Suryadipura S.Ip., M.Ipol.

Global: Jurnal Politik Internasional

The RCEP agreement is currently the largest free trade agreement involving ten ASEAN member countries and their trading partners, comprising around 30% of the world’s GDP. As an international organisation in the Southeast Asian region, ASEAN has the desire to increase its regional economic integration, one of which is through the RCEP agreement. This article aims to discuss how ASEAN attempts to enhance regional economic integration through its roles during the RCEP agreement's formation process. The author uses role theory by Lisbeth Aggestam (2006), which elaborates on four role concepts: role expectations, role conception, role performance, and role-set. This research …

Turning Ubud Into Unwto's Prototype For A World Gastronomic Destination Through Gastrodiplomacy, Alessandro Kurniawan Ulung

Global: Jurnal Politik Internasional

In 2019, the Indonesian Government proposed Ubud in Bali to become the United Nations World Tourism Organization (UNWTO) 's prototype for a world gastronomic destination. It turned out that, despite its rich inventory of gastronomic assets and attractions, Ubud met with challenges when convincing UNWTO to give it the title. To deal with this problem, the Indonesian Government practised gastrodiplomacy to influence UNWTO to endorse Ubud as the world gastronomic destination. This research, therefore, aims to explain the implementation of Indonesia's gastrodiplomacy. By using a qualitative method with interpretative analysis in place, I argued that the Government used gastrodiplomacy to …

Urban Memory Becomes An Idea In The Concept Of Spatial Planning (Study Case: Restoration Area Of Tambora District, West Jakarta), Riska Phillia, Antony Sihombing

Smart City

Urban heritage is a small part of the past of the city that holds the roots of the city's identity and culture, which are the city's identity. The strong identity of the historic area must be maintained, but this has a dilemma because of the need for change today. Therefore efforts are needed to create adaptive urban heritage areas. City spaces have a deep relationship with the people who inhabit them, with the most memorable or most memorable experiences and memories for them. This research contributes to exploring urban memory to develop conceptual spatial plans in restoration areas, using qualitative …

Study Of The Impact Of The Incompatibility Of Space Utilization In The Krukut River, Kevin Daniel Mangasi, Dwinanti Rika Marthanty

Smart City

The emergence of development on riverbanks has raised environmental problems in Indonesia, such as flooding, one of which is in the Krukut River Basin which crosses the province of DKI Jakarta. The land use change around the Krukut River causes narrowing and disrupts the absorption of rainwater and triggers sedimentation. This study aims to identify risks in the Krukut riverbank area based on the variable area of land use mismatch, population density, frequency and depth of flooding, volume of waste production, availability of waste management for water bodies and waste banks. The method used in this research is to load …

Major Paths Changes In 2013-2022 To Walkability (Case Study: Dukuh Atas Tod), Daniel Harvey Tulis, Antony Sihombing

Smart City

Development area with the concept of Transit Oriented Development (TOD) occurs so rapidly in big cities, which aims to create an integrated transportation system and is supported by the surrounding area. TOD area must have good road access for vehicles and space for pedestrians. Dukuh Atas TOD is one of the transit-oriented areas planned to be the largest TOD area in Jakarta so that developments are felt every year, including visuals and the road traffic system and pedestrian space. This research is using qualitative method by answering specific and actual variables. Time series analysis to see changes every year combined …

A Study On The Influence And Importance Of Black Science Teachers, Demetrice Smith-Mutegi

Journal of Research Initiatives

Black teachers have been known to provide positive experiences and outcomes for students, especially Black students. Nevertheless, Black science teachers are marginally represented in public classrooms across the United States, and Black students are marginally under-represented in science, technology, engineering, and mathematics (STEM). Black science teachers provide an inherent value to the education of Black children, including their ability to make science meaningful and relevant, contribute to the community where they live and work, and relate to students' experiences more intimately. Further, All levels of education should prioritize Black science teacher recruitment, and educational researchers should provide more evidence of …