Digital Commons Network^™

Inflammaging In Aged Tissues Drives Remodeling Of The Cd8+ T Cell Compartment, Irina Shchukina, Carlos J Rodriguez-Hernandez, Heather S Ruiz, Maksim Kleverov, Rachel L Mintz, Katsutaka Mineura, Subhadra C Gunawardana, Sunnie Hsiung, Bishan Bhattarai, Veronika Vachova, Jan Kossl, Denis A Mogilenko, Rachael L Field, Tran H Nguyen, Quazim A Alayo, Christopher G Huckstep, Barbora Vander Wielen, Jonathan R Brestoff, Sheila A Stewart, David W Piston, Takeshi Egawa, Daniel Kreisel, Gwendalyn J Randolph, Maxim N Artyomov

2020-Current year OA Pubs

Aging strongly impacts CD8

Regulation Of Pfh1 Helicase Activity By Nucleic Acid Interactions And Mitochondrial Ssb, María Ortiz-Rodríguez, Saurabh P Singh, Francisco J Cao-García, Roberto Galletto, Borja Ibarra

2020-Current year OA Pubs

Pif1-family helicases are essential for proper nuclear and mitochondrial genome maintenance, yet the regulation of their activities remains incompletely understood. Here, we use single-molecule manipulation and visualization techniques to dissect the real-time mechanochemical behavior of Pfh1, the sole Pif1-family helicase in

Mining And Sustainable Development In Sierra Leone: The Role Of Institutional Quality, Ibrahim Massaquoi

Journal of Sustainable Mining

While mining can drive economic growth, create jobs, and promote infrastructural development, it also poses risks to the environment, human health, and social well-being. Therefore, to achieve sustainable development, responsible mining is crucial. This study empirically examines the role of institutional quality in the mining-sustainable development nexus in Sierra Leone. With the use of the planetary pressures-adjusted human development index (PHDI) as a comprehensive measure of sustainable development, the study is able to integrate economic, social, and environmental dimensions. The autoregressive distributed lag (ARDL) model confirms the existence of both short-run and long-run dynamics. The results of the study show …

Hope And The Handiwork Of Varda: Celestial Signposts Of The Music’S Mending, Kristine Larsen

Journal of Tolkien Research

Varda, the Queen of the Valar, wields tremendous cosmological power in Tolkien’s legendarium. It is not without cause that Melkor fears her, as her power is literally written in the stars for all to see. Not only do her bright stars and constellations provide light against the darkness, but two of her creations – the Valacirca (Big Dipper) and Menelmacar (Orion) – are direct and intentional warning signs to Melkor of his unavoidable defeat in the Last Battle at the end of days. Indeed, Melkor’s capture by the armies of the Valar at the end of the First Age is …

Biopolymer Fibre Production And Metal Free Circuitry, Natalie M. Durdle Miss

Defensive Publications Series

This paper details a decentralized, open-source manufacturing framework designed to produce structural textiles and metal-free electrical circuits using public-domain chemistry and low-cost, unregulated hardware. The platform utilizes expired late-nineteenth and early-twentieth-century patent methodologies, optimizing them for domestic, kitchen-scale replication with non-toxic, food-safe components. The primary structural substrate is derived from the acid-precipitation of casein proteins from dairy fractions, which are solubilized in a mild alkali solution to form a viscous spinning dope. To address the historical dependency on toxic cross-linkers like formaldehyde, this framework introduces three accessible micro-extrusion methodologies that utilize a non-toxic, ten percent aqueous potassium alum bath: (1) …

The Metric Field And Its Primitives, Steven Kirkland

Defensive Publications Series

The Metric Field and Its Primitives is the formal-mathematics layer of a research project whose popular-science companion, Inners Guide to the Hyper Loop, ships the story. This volume ships the mathematics: definitions, theorems, proofs, falsifier ladders, and the algebra the framework reads across substrates from atomic spectra to slime moulds to the cosmic substrate.

The framework. A candidate fundamental framing under Metric Field Ontology (MFO) commitments. The conventional readings of physics — general relativity, quantum field theory, the Standard Model, ΛCDM cosmology, M-theory's eleven-dimensional supergravity — are preserved at the mathematical level. What is shifted is the ontological framing: …

Computer Aided Field Investigation (Cafi): A Provenance-First Architecture For Real-Time Msme Credit Decisioning In India, Murali Krishnan

Defensive Publications Series

Computer Aided Field Investigation (CAFI) is a provenance-first architecture for real-time MSME credit decisioning in India, replacing the photographs-and-narrative output of conventional field visits with a hash-chained, tablet-captured, audit-defensible evidence graph. The five-layer architecture combines geo-fenced tablet field capture, DPDP-compliant consent-bound media acquisition, an append-only provenance data model in which every credit-decision fact links to immutable source artifacts, a deterministic real-time triangulation engine cross-validating borrower declarations against Goods and Services Tax (GST) returns and Account Aggregator (AA) bank statement data, a quality-assurance anomaly layer detecting photo perceptual hash collisions, GPS clustering, visit duration outliers, and field-officer response patterns, and a …

Water System #30 Solar‑Thermal, Vortex‑Enhanced Desalination System, Michael Victor Caldwell Mr.

Defensive Publications Series

Water System #30 solar‑thermal, vortex‑enhanced desalination system designed for off‑grid, humanitarian, and disaster‑response water purification. The system uses concentrated solar heat, a cyclonic evaporation chamber, and a multi‑stage contaminant separation process to convert seawater or high‑TDS brackish water into potable water without membranes, high‑pressure pumps, or consumables.

To ensure stable operation under variable sunlight and high‑salinity conditions, the system integrates:

• A phase‑change thermal flywheel to buffer solar fluctuations

• A passive ultrasonic scale‑prevention ring to eliminate mineral buildup

• A hydrophobic gyroid demister to prevent salt‑mist carryover

• A high‑conductivity polymer condenser wrap to increase distillate yield

This disclosure provides a complete, manufacturable, …

Agentic System For Real-Time Social Media Intelligence Synthesis And Strategic Briefing Generation, Kevin Babu

Defensive Publications Series

A technique is proposed for real-time social media intelligence synthesis and strategic briefing generation. Engagement metrics associated with social media content associated with a user are obtained. An artificial intelligence (AI) agent configured to derive data for a social media briefing based on the engagement metrics is instantiated. The AI agent is caused to calculate an engagement velocity of the social media content based on a rate of change of the engagement metrics over a time period. The AI agent is caused to to determine a brand sentiment forecast and a viral breakout point based on the engagement velocity and …

System And Method For Automated Testing Gap Categorization And Codebase Vulnerability Localization, Aman Singh

Defensive Publications Series

A system related to automated testing gap categorization and codebase vulnerability localization in large-scale distributed computing environments. The system may receive an incident record containing unstructured text and identifiers pointing to external systems, obtain content from the external systems based on the identifiers, and aggregate the content into a unified context payload. The system may generate a fingerprint data structure based on the unified context payload and a versioned analysis prompt to determine whether AI model analysis is needed. The system may perform multi-stage AI analysis including identifying where a supervised analysis system indicated a testing gap, classifying the type …

Gaussian-Weighted K-Nearest Distribution Point Mapping For Smooth Probability Estimation, Ania Kacewicz, Jud Dagnall

Defensive Publications Series

Proposed herein is a method to map compressed data representations to smooth probability distributions by distributing each data point's weight across its k-nearest distribution bins using Gaussian decay, creating a natural exponential falloff where closer bins receive exponentially more weight than distant bins. Unlike traditional methods that either create spiky distributions (nearest-neighbor-only) or over-smooth local features (global kernel density estimation), a bounded Gaussian approach, as proposed herein, confines smoothing to local neighborhoods while maintaining smoothness within those regions. The algorithm includes circular distance support for temporal data (ensuring hour 23 is treated as 1 hour from hour 0, not 23 …

Optimized, Context-Aware Large Language Model (Llm) Architecture For Artificial Intelligence (Ai)-Native Sixth-Generation (6g) Networks, Swapnil Barai, Ravi Shekhar, Dishant Parikh, Gaurav Kumar Rungta

Defensive Publications Series

The evolution toward sixth-generation (6G) networks introduces agentic communication, in which autonomous software agents interact and execute actions based on real-time environmental data. Large language models (LLMs) provide reasoning capability for such agents, but deploying an individual LLM for each agent can be operationally and economically infeasible. This disclosure presents a consolidated, context-aware LLM architecture that centralizes LLM resources within a 6G core and logically separates the resources into control plane (CP) and user plane (UP) instances. Using a shared resource model and a context-tagging mechanism based on device type, radio access technology (RAT), and function type, the architecture supports …

Integrated Passive Design Strategies For Enhancing Energy Performance Of Hotel Buildings In Hot-Arid Climates: A Simulation-Based Study, Esraa Ebrahiem Abu-Elenain

HBRC Journal

Sustainable architectural design strategies offer effective solutions for enhancing energy efficiency and reducing operational costs in energy-intensive buildings, such as hotels in hot-arid climates. However, limited research has addressed the integrated application of multiple passive design strategies within hotel buildings using a unified simulation-based framework. This study investigates the combined application of wind catchers (Malqaf), adaptive mashrabiya shading systems, and high-performance glazing on a proposed hotel floor in Ras Sedr, Egypt. The design was modeled in Autodesk Revit and analyzed through dynamic simulation using EnergyPlus. A comparative approach was adopted, including a baseline scenario and an improved design scenario. The …

Enhancing Social Activity Through Climate-Adaptive Design In Hot-Humid Campus Open-Spaces: A Case Study Of The University Of Basrah In Iraq, Noor A. Almansor, Farah Ahmed Thiab, Riyam Rajab Fenjan

HBRC Journal

Outdoor open spaces between university buildings support students' community interactions and academic achievements. However, in hot-humid climate zones, some of these spaces lack activity and experience social withdrawal due to thermal discomfort. This is seen on the University of Basrah campus. To address this, the study aimed to identify the most suitable climate-adaptive design pattern to improve thermal comfort and, in turn, enhance students' social presence in the University of Basrah's neglected, peripheral outdoor campus spaces. A convergent mixed-method case study was applied. First, measurable environmental and social factors were identified from related studies. Next, two open spaces in the …

The Impact Of Climate Change On Glass Facades: A Bibliometric Analysis, Pelin Akın, Güneş Mutlu Avinç

HBRC Journal

Climate change has direct impacts on the design and performance of building envelopes, necessitating new approaches in the discipline of architecture. In this study, a bibliometric analysis was conducted to understand the effects of climate change on glass façade systems. The 612 academic publications obtained from the Web of Science database were analyzed through R Studio Biblioshiny. Within the scope of the study, publication trends, key themes, prominent authors, institutions and geographical distributions were evaluated in detail. According to the findings of the research, it was indicated that research has gained momentum especially after 2016, focusing on themes such as …

A Hybrid Deep Learning Framework For Multi-Class Retinal Disease Classification, Ali M. Duhaim, Abbas M. Al-Bakry

AUIQ Technical Engineering Science

Ocular diseases such as diabetic retinopathy, glaucoma, and cataract remain major causes of vision loss worldwide, creating an increasing demand for accurate and reliable automated diagnostic systems. Although deep learning techniques have demonstrated strong performance in retinal image analysis, their clinical adoption is still limited by challenges related to predictive reliability, robustness, and interpretability. This study presents HEFR-Net (Hybrid EfficientNet-B3 and ResNet-50 Feature-Fusion Network), a hybrid deep learning framework designed for multi-class classification of retinal fundus images. The proposed architecture integrates EfficientNet-B3 and ResNet-50 through feature-level fusion, enabling the model to capture both fine-grained texture patterns and high-level structural characteristics …

High Temperature High Pressure Extraction Methods, Natalie M. Durdle Miss

Defensive Publications Series

A method is disclosed for accelerating the extraction of flavor volatiles, peptides, and gelatin from animal tissue using high-temperature, high-pressure, non-turbulent conditions to prevent emulsion. The disclosure further details a rapid clarification protocol using mechanically released intracellular proteins to form an aerated, buoyant filtration raft, as well as a cryo-filtration process leveraging a self-assembling gelatin polymer network to separate lipids and hazy proteins from an aqueous phase. These processes are specified for both artisanal culinary production and mass-scale commercial soup, pet food, and protein recovery manufacturing operations.

Accelerated Production Of Culinary Stocks, Natalie M. Durdle Miss

Defensive Publications Series

A method is disclosed for accelerating the extraction of flavor volatiles, peptides, and gelatin from animal tissue using high-temperature, high-pressure, non-turbulent conditions to prevent emulsion. The disclosure further details a rapid clarification protocol using mechanically released intracellular proteins to form an aerated, buoyant filtration raft, as well as a cryo-filtration process leveraging a self-assembling gelatin polymer network to separate lipids and hazy proteins from an aqueous phase.

Secure Live Streaming Architecture With Continuous Visual Identity Verification And Avatar‑Based Subject Representation, Krzysztof P. Bednarz

Defensive Publications Series

This publication describes a secure live streaming software architecture in which a human subject is continuously recognised using computer vision, visually occluded, and replaced in real time with an avatar-based graphical representation. The system supports local, remote, and distributed processing across mobile devices, desktop systems, and network-connected services. Identity verification is enforced throughout the streaming session, and streaming output is automatically frozen, paused, or terminated if the recognised subject no longer matches an authorised identity profile. This version extends the disclosure to include explicit failure modes and attack scenarios, strengthening its value as defensive prior art.

Dynamic Input Layering To Animate A Virtual Avatar Over A Mobile Video Capture Using Concurrent Front-Camera Tracking, Audio, And Ui Commands, Krzysztof P. Bednarz

Defensive Publications Series

This publication describes a mobile software architecture and method for real-time animation of a virtual avatar over a live or recorded video stream captured from a mobile device. The system concurrently utilises a back-facing for environmental video capture, a front-facing camera for facial tracking, and an audio input for lip synchronisation. A synchronisation and buffering mechanism aligns video, audio, and animation data streams in near real time, ensuring temporally coherent avatar animation over live or recorded video. These heterogeneous inputs are dynamically layered and synchronised to drive a two-dimensional (2D) or three-dimensional (3D) avatar while supporting both local recording and …

Crime-Related Media Consumption And Fear Of Crime Victimization: The Moderating Roles Of Stress And Coping, Katelyn Elizabeth Byers

Walden Dissertations and Doctoral Studies

No abstract provided.

Improving Antihypertensive Medication Adherence Through Patient-Centered Assessment In Rural Primary Care, Tiesha Keoni Mathis

Walden Dissertations and Doctoral Studies

No abstract provided.

An Emotional Intelligence Staff Education Program For Patient-Aligned Care Team (Pact) Members, Linda Rogers

Walden Dissertations and Doctoral Studies

No abstract provided.

Successful Strategies Leaders Of New Car Dealerships Use To Maximize Retention Of Salespeople, Kacey Patrice Taylor

Walden Dissertations and Doctoral Studies

No abstract provided.

Perspectives Of Formerly Incarcerated African American Males On Prison Vocational Work Programs On Reducing Recidivism, Mark Steven Frazier

Walden Dissertations and Doctoral Studies

No abstract provided.

Popgenhelpr: An R Package To Streamline And Facilitate Informed Population Genomic Analyses And Visualization Of Genetic Ancestry, Diversity And Differentiation, Keaka Farleigh, Mason O. Murphy, Christopher Marie Blair, Tereza Jezkova

Publications and Research

Analysing large population genomic datasets requires an interdisciplinary skillset. Beyond a knowledge base in genetics and population biology, population genomic analyses involve computer science and statistics, representing a barrier for researchers without experience in those fields. PopGenHelpR seeks to lower this barrier by enabling researchers to perform population genomic analyses and generate near-publication quality figures in a streamlined and informed fashion. PopGenHelpR allows users to estimate genetic diversity within populations as well as differentiation among populations and individuals from single nucleotide polymorphism data. PopGenHelpR includes commonly used measures such as observed heterozygosity and FST. PopGenHelpR also provides five …

“Big River People”: Human-Nature Interactions In The Mekong And Columbia River Basins, Andrew M. Stone

Forest and Society

The Mekong and Columbia Rivers are a world apart. Yet rivers instantiate and manifest critical ecological relations. This paper draws on qualitative interviews, community dialogues, historical documents, and ceremony-based encounters to examine political practices among "big river people'' in the Mekong and Columbia River basins. It interprets participants' narratives and actions as expressions of ontological politics, i.e., contestation of imposed realities and lifeways. Participants link environmental degradation to violations of relational ethics. Across both study groups, elders and knowledge holders describe ecological and cultural loss as forms of ongoing violence enacted through hydropower development, displacement, and resulting erasure of ways …

A Review Of Full-Lifecycle Management Practices For Blue Mining Centered On Sustainable Development And Resource Efficiency, Hou Zhengmeng, Zhang Shengyou, Chen Qianjun, Sun Wei, Zhang Tian, Cai Nan, Huang Liangchao, Wang Qichen, Shi Tianle, Xu Xiaochuan

Coal Geology & Exploration

Against the backdrop of China’s goals of peak carbon dioxide emissions and carbon neutrality, along with the growing demand for critical minerals, this study presents a systematic review of domestic and international literature and engineering cases. Based on the Blue Mining concept proposed by Langefeld’s team of the Clausthal University of Technology and from the perspective of planning forward, this study organizes key technologies, treatment pathways, and essentials of full-lifecycle management used to transition mines from single-purpose stopes to multifunctional infrastructures. Centered on four guiding principles, i.e., energy, ergonomics, water resources, and circularity, this study reviews the synergetic planning process …

Advances In Research On Eco-Geological Environment Monitoring Of Underground Coal Mining Areas Based On Airborne Remote Sensing, Li Jun, Zou Zhaohui, Zhang Chengye, Wang Yi, Cheng Yang, Xu Lianhang, Zhang Jinhe, Liu Chuanrui, Liang Lixia

Coal Geology & Exploration

Background Timely and effective monitoring of the current status of eco-geological environment holds great significance for scientific decision-making regarding both geological environment protection and ecological restoration in underground coal mining areas. Owing to its advantage of large-scale and rapid monitoring, airborne remote sensing technology has emerged as an important approach to the eco-geological environment monitoring of mining areas. Advances This study first clarifies relevant concepts of eco-geological environment monitoring, as well as the monitoring requirements and contents specific to underground coal mining areas. Accordingly, it presents a summary of the advances in research on airborne remote sensing technology for the …

Improving Depression Severity Assessment And Appointment Adherence Among Young Adults Aged 18–30: A Staff Education Project, Vivian Ngefor Ndem

Walden Dissertations and Doctoral Studies

No abstract provided.