Digital Commons Network^™

Sialidase Fusion Protein Protects Against Influenza Infection In A Cigarette Smoke-Induced Model Of Copd, Cheng-Yen Chang, Dominique Armstrong, John M Knight, Trevor V Gale, Stephen Hawley, Max Wang, Nancy Chang, David B Corry, Farrah Kheradmand

Faculty, Staff and Students Publications

First- and secondhand smokers are at an increased risk for influenza virus (IFV)-related respiratory failure and death. Despite approved influenza antiviral treatments, there is an unmet need for treatments that can improve outcomes in populations at risk for respiratory failure, including tobacco users with Chronic Obstructive Pulmonary Disease (COPD). Here we show that the sialidase fusion protein, DAS181, reduced viral burden, mitigated inflammation, and attenuated lung function loss, consistent with broad-spectrum anti-influenza responses in a mouse model of COPD and IFV-A infection. Treatment with DAS181 reprogramed the sialic acid-binding immunoglobulin-like lectins (Siglecs) in alveolar macrophages, increased expression of phagocytic marker …

Rapid Diagnostic Sequencing Of Stool Dna Using Targeted Nanopore Sequencing In Patients With A Pulmonary Tuberculosis Diagnosis, Tara Ness, Nontobeko Maphalala, Wethusonkhe Khumalo, Doctor Sibandze, Abigail Seeger, Maia Madison, Anca Vasiliu, Durbin Mulengwa, Clement Gascua, Mangaliso Ziyane, Sindisiwe Dlamini, Gugu Maphalala, Eric Bortz, Alexander Kay, Christoph Lange, Viola Dreyer, Tanja Niemann, Stefan Niemann, Andrew Dinardo, Anna Mandalakas, Stool4tb Global Partnership

Faculty, Staff and Students Publications

Background: Approximately 1.25 million individuals died of tuberculosis in 2023, in part due to ineffective treatment. In patients with paucibacillary tuberculosis, microbiologic confirmation and drug resistance testing via respiratory specimens is challenging; hence, stool samples are increasingly used for microbiologic confirmation. Targeted next-generation sequencing (tNGS) of stool DNA may improve detection of drug-resistant (DR) tuberculosis, helping patients receive appropriate treatments.

Methods: We assessed the ability of a nanopore tNGS approach using stool to detect drug resistance in a prospective, nested cohort of consecutive participants in Eswatini with pulmonary tuberculosis confirmed via sputum culture or sputum GeneXpert Ultra from 2020 to …

Endothelial Micu1 Protects Against Vascular Inflammation And Atherosclerosis By Inhibiting Mitochondrial Calcium Uptake, Lu Sun, Ruixue Leng, Monan Liu, Meiming Su, Qingze He, Zhidan Zhang, Zhenghong Liu, Zhihua Wang, Hui Jiang, Li Wang, Shuai Guo, Yiming Xu, Yuqing Huo, Clint L Miller, Maciej Banach, Yu Huang, Paul C Evans, Jaroslav Pelisek, Giovanni G Camici, Bradford C Berk, Stefan Offermanns, Junbo Ge, Suowen Xu, Jianping Weng

Faculty, Staff and Students Publications

Mitochondrial dysfunction fuels vascular inflammation and atherosclerosis. Mitochondrial calcium uptake 1 (MICU1) maintains mitochondrial Ca2+ homeostasis. However, the role of MICU1 in vascular inflammation and atherosclerosis remains unknown. Here, we report that endothelial MICU1 prevents vascular inflammation and atherosclerosis by maintaining mitochondrial homeostasis. We observed that vascular inflammation was aggravated in endothelial cell–specific Micu1 knockout mice (Micu1ECKO) and attenuated in endothelial cell–specific Micu1 transgenic mice (Micu1ECTg). Furthermore, hypercholesterolemic Micu1ECKO mice also showed accelerated development of atherosclerosis, while Micu1ECTg mice were protected against atherosclerosis. Mechanistically, MICU1 depletion increased mitochondrial Ca2+ influx, thereby decreasing the expression …

The Passive-Active Interaction (Pai) Model: Redefining Audio Interactions In Video Game Music, Morgan A. Weeks

LSU Doctoral Dissertations

Scholarship on music in video games has focused on the player in two main ways: the psychological effect music has on the player and the physical, kinesthetic relationship between the player’s inputs and the game’s music. This dissertation builds on this work by exploring gameplay moments in which the music informs the player’s inputs through rhythms, tempo, harmonic relationships, and changes in the musical texture. Using “analytical play” (Summers 2016), rhythmic analysis, looping analysis, and harmonic observations, alongside a variety of different video games, consoles and genres, I have developed an analytical Passive-Active Interaction (PAI) Model that is applicable to …

How Financial Aid Affects The Odds Of Study Abroad Participation For Students Of Color, Patrick Newcomb

LSU Doctoral Dissertations

Prior research has shown that studying abroad provides students with enriching, diverse educational experiences with positive personal, academic, and professional outcomes. Despite the benefits, only a small portion of American higher education students participate in study abroad programs. Students of color disproportionately study abroad at lower rates than White students. Since cost is often cited as the primary barrier preventing education abroad, this study examined the types of financial aid associated with study abroad access and participation.

This study used data from the National Postsecondary Student Aid Study, which is a nationwide dataset designed to represent the makeup of institutions …

Adoption Of Virtual Influencers By The Healthcare Industry: Benefits And Drawbacks, Jessica L. Holden, Ismet Anitsal, Melek Meral Anitsal

AMTP Proceedings 2025

Social media influencers are thought leaders and influence others' attitudes, opinions, and behaviors (Pourkarim et al., 2023. Laszkiewicz & Kalinska, 2023). The healthcare industry currently utilizes social media and social media influencers to provide generalized health advice and opinions on and experiences with different providers (Reed & Feilding, 2022). However, the use of social media by healthcare businesses is still relatively novel (Gijsen et al., 2020), although it is becoming increasingly used for healthcare education and decision-making (Stellefson et al., 2020). Within the social media marketing space, there has been a rise in the use of virtual influencers. A Virtual …

Who And Its Enduring Commitment To Global Pediatrics, Peter J Hotez

Faculty, Staff and Students Publications

No abstract provided.

Ethics Of Learning Surgical Autonomy In Safety-Net Hospital Systems With Patients Who Are Incarcerated, Kala T Pham, Rachel W Davis

Faculty, Staff and Students Publications

Safety-net hospitals care for patients who are incarcerated and are key environments in which surgical trainees learn to wield their professional autonomy. This article explores ethical questions raised by surgical trainees' participation in carceral care and canvasses possible responses to those questions.

Klf4 Enhances Transplantation-Induced Hematopoiesis By Inhibiting Tlrs And Noncanonical Nfκb Signaling At A Steady State, Chun Shik Park, Cory S Bridges, Andrew H Lewis, Taylor J Chen, Saptarsi Shai, Wa Du, Monica Puppi, Barry Zorman, Sumazin Pavel, H Daniel Lacorazza

Faculty, Staff and Students Publications

The transcription factor Krüppel-like factor 4 (KLF4) acts as a transcriptional activator and repressor. KLF4 plays a role in various cellular processes, including the dedifferentiation of somatic cells into induced pluripotent stem cells. Although it has been shown to enhance self-renewal in embryonic and leukemia stem cells, its role in adult hematopoietic stem cells (HSCs) remains underexplored. We demonstrate that conditional deletion of the Klf4 gene in hematopoietic cells led to an increased frequency of immunophenotypic HSCs in the bone marrow, along with a normal distribution of lymphoid and myeloid progenitor cells. Noncompetitive bone marrow transplants showed normal engraftment and …

Use Of Wastewater Grit And Milorganite Chaff In Concrete, Carter Deinhammer

Master's Theses (2009 -)

Wastewater grit is a major byproduct from preliminary municipal wastewater treatment. Chaff is a collection of dried biosolids generated as a waste product from Milorganite® fertilizer production. Because landfilling is a costly and unsustainable method, the development of technologies for diverting grit from landfills to a useful product by tapping grit’s inherent values (e.g., sand and gravel) are of great interest. Chaff, consisting of fibers, provides a potential source for bolstering concrete tensile strength through internal means. This research has proposed a concept of grit and chaff additive-based concrete, an expansion of the grit-assisted patch material developed (GAP) in previous …

Beyond The Bickering: Examining Event, Victim, And Offender Characteristics For Sibling Abuse Incidents In Oregon, Isabella M. Starr

University Honors Theses

Sibling violence (SV) is the most prevalent form of intrafamilial and domestic violence, yet it remains underrecognized and lacks the systematic attention given to other forms of family violence. Often minimized or misclassified as typical sibling rivalry, SV can inflict serious and lasting physical, emotional, and psychological harm on its victims. This study explores the characteristics of sibling violence incidents reported to law enforcement in Oregon between 2016 and 2023, using data from the National Incident-Based Reporting System (NIBRS). Through an analysis of 5,793 single-victim, single-offender incidents, the research examines demographic patterns among victims and offenders, incident dynamics, and typological …

Differential Treatment Effects On Β-Cell Function Using Model-Based Parameters In Type 2 Diabetes: Results From The Glycemia Reduction Approaches In Diabetes: A Comparative Effectiveness Study (Grade), Kristina M Utzschneider, Mark Tripputi, Nicole M Butera, Andrea Mari, Samuel P Rosin, Mary Ann Banerji, Richard M Bergenstal, Necole Brown, Anders L Carlson, Ralph A Defronzo, Michaela R Gramzinski, Tasma Harindhanavudhi, Alexandra Kozedub, William I Sivitz, Michael W Steffes, Ashok Balasubramanyam, Neda Rasouli

Faculty, Staff and Students Publications

Objective: To evaluate how model-based parameters of β-cell function change with glucose-lowering treatment and associate with glycemic deterioration in adults with type 2 diabetes (T2D).

Research design and methods: In the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE), β-cell function parameters derived from mathematical modeling of oral glucose tolerance tests were assessed at baseline (N = 4,712) and 1, 3, and 5 years following randomization to insulin glargine, glimepiride, liraglutide, or sitagliptin, added to baseline metformin. Parameters included insulin secretion rate (ISR), glucose sensitivity (insulin response to glucose), rate sensitivity (early insulin response), and potentiation. Linear mixed-effects …

Postnatal Zika And Dengue Infection And Their Effects On Neurodevelopment Among Children Living In Rural Guatemala, Edwin J Asturias, Amy K Connery, Daniel Olson, Molly M Lamb, Alejandra Paniagua-Avila, Evan J Anderson, Chris Focht, Alison M Colbert, Muktha Natrajan, Jesse J Waggoner, Erin Scherer, D Mirella Calvimontes, Guillermo A Bolaños, Desirée Bauer, Paola Arroyave, Sara Hernández, Maria A Martinez, Aida V Ralda, Neudy Rojop, Edgar E Barrios, Andrea Chacon, Walla Dempsey, Kay M Tomashek, Wendy A Keitel, Hana M El Sahly, Flor M Muñoz

Faculty, Staff and Students Publications

Background: Prenatal Zika virus (ZIKV) infection leads to microcephaly and adverse neurodevelopment. The effects of postnatal ZIKV infection on the developing brain are unknown. We assessed the neurodevelopmental outcomes of children exposed postnatally during the ZIKV epidemic.

Methods: A prospective study enrolled infants 0-3 months of age and their mothers, and children 1.5-3.5 years of age in rural Guatemala from 2017 and were followed for 12 months until 2019. Neurodevelopment was evaluated using the Mullen Scales of Early Learning (MSEL). ZIKV and dengue virus (DENV) infections were identified by polymerase chain reaction (PCR) using active surveillance. Serological analyses, stratified by …

Preferences For Survivorship Education And Delivery Among Latino And Non-Latino Childhood Cancer Survivors And Caregivers, Omar Shakeel, Shiley Aguilar, Alicia Howell, Ashley Ikwuezunma, Olga Taylor, M Fatih Okcu, Ranjan Bista, Jill Hartley, Rodrigo Eraña, Juan Carlos Bernini, Lisa Kahalley, Michael Scheurer, Maria Monica Gramatges

Faculty, Staff and Students Publications

Purpose: To assess survivor and parent perceptions of the long-term survivor visit and preferences regarding accessing health information, survivorship education, and support networks in rural and metropolitan regions of Texas.

Methods: Leveraging the multi-institutional Survivorship and Access to Care for Latinos to Understand Disparities (SALUD) cohort, we administered a 26-item bilingual survey to adult survivors of childhood cancer and parents of younger survivors. Characteristics and responses were compared between survivors vs. parents and Latinos vs. non-Latinos using a t test or Fisher exact test. Odds ratios for the outcomes of interest were calculated with 95% confidence intervals.

Results: We received …

Climate Change Detection In Four Locations In Peninsular Malaysia For Green Sustainability Awareness, Noor Kesuma Mohd Yazid, Norshahida Shaadan, Firdaus Mohamad Hamzah, Nurain Ibrahim, Mahayaudin M.Mansor

Malaysian Journal of Computing (MJoC)

Climate change impacts ecosystems, often resulting in the extinction of many species and their habitats and harm to human health. Preserving and protecting green spaces is essential to maintaining ecosystem health. This study aims to detect and examine climate change and its impact on temperature and rainfall at four locations in Malaysia to increase green environment sustainability awareness. The methodology involved investigating the pattern of climate variation using several visualization tools, the Mann-Kendall test, the EWMA control chart, and the Kruskall-Wallis test. Data on monthly average temperature and rainfall amount for the 30 years between 1989 and 2018 was obtained …

Localization Module In User Experience Questionnaire For Cross Cultural Website Design, Nurhayati Mohd Husni, Nur Atiqah Sia Abdullah

Malaysian Journal of Computing (MJoC)

The importance of User Interface (UI) and User Experience (UX) in ensuring the practicality and usability of websites for users is well-recognized. The User Experience Questionnaire (UEQ) is widely employed to evaluate these aspects of a product, ensuring linguistic and cultural appropriateness for its target locale based on country, region, or language. However, the UEQ lacks a module specifically designed to assess the localization properties of a product. This research aims to extend the UEQ by introducing a localization module that adheres to cross-cultural design principles. The study involved a systematic literature review to identify potential items for the localization …

Integrated Cybersecurity Framework For Enhanced Threat Detection And Incident Response In The Digital Era, Azlin Ramli, Mohamad Yusof Darus, Yusnani Mohd Yussoff, Badri Azni, Kanqi Xie

Malaysian Journal of Computing (MJoC)

This research presents a novel cybersecurity framework aimed at improving threat detection and incident response in today's complex digital environment. The framework integrates three key components: advanced threat detection, accelerated incident response, and continuous risk assessment, adopting a holistic and adaptive approach. It leverages machine learning (ML) and artificial intelligence (AI) to proactively identify and counter evolving cyber threats, moving beyond traditional reactive systems. The advanced threat detection element utilizes AI-driven analytics to spot anomalous patterns and forecast potential vulnerabilities, thus enhancing threat visibility. The accelerated incident response streamlines automated responses to common threats, significantly cutting response times. Complementing these …

A Preliminary Strategy Towards Supporting The Automation Of Shariah Compliant Requirements, Normi Sham Awang Abu Bakar, Azlin Nordin, Madihah Sheikh Abdul Aziz, Norzariyah Yahya, Aminudin Che Ahmad

Malaysian Journal of Computing (MJoC)

Web-based technology offers a wide range of online services in practically every industry, including the medical field. The ISO MS 1900:2014 certification has been awarded to the Sultan Ahmad Shah Medical Centre (SASMEC)@IIUM (Shariah-based Quality Management System). All hospital reporting processes are currently carried out manually using a variety of physical forms, such as the food premise inspection form, the complaint form, and the programme monitoring form to support the implementation and monitoring of the shariah- compliance-related activities. This strategy necessitates a considerable amount of effort, time, and resources to manage these manual activities. These problems have led to insufficient …

Examining The Impact Of Feature Selection Techniques On Machine And Deep Learning Models For The Prediction Of Covid 19, Hafiza Zoya Mojahid, Jasni Mohamad Zain, Marina Yusoff, Abdul Basit, Abdul Kadir Jumaat, Mushtaq Ali

Malaysian Journal of Computing (MJoC)

Feature selection is a vital preprocessing step for identifying the most informative features in complex datasets, enhancing the efficiency and accuracy of machine learning models. Its applications extend across various domains, including big data analytics, finance, chemometrics, medical diagnostics, biological research, intrusion detection systems, and renewable energy solutions. In medical contexts, feature selection serves a dual purpose: it reduces dimensionality while simultaneously improving the comprehension of disease etiology. This study delves into key variable selection methods—specifically Recursive Feature Elimination (RFE), Principal Component Analysis (PCA) and Least Absolute Shrinkage and Selection Operator (LASSO). We evaluate the interaction of these methods with …

The Prevalent Mindset Pattern (Deliberative-Implemental) As A Predictor Of Positive Thinking Among University Students, Susan Rasim Khalil Arafa, Thaer Ahmad Ghbari

Journal of Educational and Psychological Studies

The study aimed to identify the prevailing mindset (deliberative-implemental) among university students and its ability to predict their positive thinking, as well as to determine whether there were statistically significant differences in mindset (deliberative-implemental) according to gender and faculty variables. To achieve the study objectives, data were collected using two research instruments: the Deliberative-Implemental Mindset Scale, which consists of two dimensions— deliberative mindset and implemental mindset—and the Positive Thinking Scale, which includes 25 items distributed across five dimensions: optimism and general satisfaction, emotional regulation and emotional intelligence, acceptance of others and personal responsibility, forgiveness and self-acceptance, and love of learning …

Racial Disparities In Utilization Of Medications And Disease Outcomes In Inflammatory Bowel Disease Patients, Khaled Alsabbagh Alchirazi, Osama Hamid, Thabet Qapaja, Mohammad Aldiabat, Nour Azzouz, Motasem Alkhayyat, Miguel Regueiro

2020-Current year OA Pubs

BACKGROUND: Although traditionally associated with White European ancestry, inflammatory bowel disease (IBD) has increased among different races and ethnicities. Large studies conducted in the United States and Canada have identified more complex disease phenotypes among Black patients. Our study aimed to investigate disparities in IBD treatments and outcomes between Black and White patients in the United States.

METHODS: Using the TriNetX database, adult IBD patients were divided into 2 groups based on race: Black and White patients with IBD, Crohn's disease (CD), or ulcerative colitis (UC). Medical therapy and disease outcomes were evaluated in both groups with 1:1 propensity-score matching. …

Dynamic Femoral Head Coverage Following Periacetabular Osteotomy For Developmental Dysplasia Of The Hip, Christina A Bourantas, Emma C Behrman, Molly C Shepherd, Keith R Lohse, John C Clohisy, Michael D Harris

2020-Current year OA Pubs

BACKGROUND: Developmental dysplasia of the hip reduces hip stability due to insufficient femoral head coverage. Periacetabular osteotomy surgery aims to increase this coverage. Typically measured using radiographs, most coverage assessments are limited to static hip positions and cannot capture 3D anatomy. This study quantified how dynamic 3D femoral coverage changes during gait and squat after periacetabular osteotomy surgery and compared dynamic coverage to static measures.

METHODS: Pre- and post-surgery CT scans from 38 patients with hip dysplasia were used to reconstruct 3D femur and pelvis bones with which gait and squat were simulated. Models of 38 control subjects were also …

Factors Associated With Shock At Presentation In Kawasaki Disease Versus Multisystem Inflammatory Syndrome In Children Associated With Covid-19, Supriya S Jain, William B Orr, Et Al.

2020-Current year OA Pubs

BACKGROUND: While clinical overlap between Kawasaki disease (KD) and multisystem inflammatory syndrome in children (MIS-C) has been evident, information regarding those presenting with shock has been limited. We sought to determine associations with shock within and between diagnosis groups.

METHODS: The International KD Registry enrolled contemporaneous patients with either KD or MIS-C from 39 sites in 7 countries from January 1, 2020, to January 1, 2023. Demographics, clinical features and presentation, management, laboratory values, and outcomes were compared between the diagnosis and shock groups.

RESULTS: Shock at presentation was noted for 19 of 672 KD patients (2.8%) and 653 of …

Microvascular Aberrations Found In Human Polycystic Kidneys Are An Early Feature In A Pkd1 Mutant Mouse Model, Daniyal J Jafree, Yoshiharu Muto, Benjamin D Humphreys, Et Al.

2020-Current year OA Pubs

Therapies targeting blood vessels hold promise for autosomal dominant polycystic kidney disease (ADPKD), the most common inherited disorder causing kidney failure. However, the onset and nature of kidney vascular abnormalities in ADPKD are poorly defined. Accordingly, we employed a combination of single-cell transcriptomics; three-dimensional imaging with geometric, topological and fractal analyses; and multimodal magnetic resonance imaging with arterial spin labelling to investigate aberrant microvasculature in ADPKD kidneys. Within human ADPKD kidneys with advanced cystic pathology and excretory failure, we identified a molecularly distinct blood microvascular subpopulation, characterised by impaired angiogenic signalling and metabolic dysfunction, differing from endothelial injury profiles observed …

Statistical Properties Of Functional Connectivity Mri Enrichment Analysis In School-Age Autism Research, Austin S Ferguson, Tomoyuki Nishino, Natasha Marrus, John R Pruett Jr, Alexandre A Todorov, Et Al.

2020-Current year OA Pubs

Mass univariate testing on functional connectivity MRI (fcMRI) data is limited by difficulties achieving experiment-wide significance. Recent work addressing this problem has used enrichment analysis, which aggregates univariate screening statistics for a set of variables into a single enrichment statistic. There have been promising results using this method to explore fcMRI-behavior associations. However, there has not yet been a rigorous examination of the statistical properties of enrichment analysis when applied to fcMRI data. Establishing power for fcMRI enrichment analysis will be important for future neuropsychiatric and cognitive neuroscience study designs that plan to include this method. Here, we use realistic …

Femoral Nail And Cement Static Spacer Technique For The Treatment Of Chronic Periprosthetic Knee Infection, Katherine Mistretta, Caroline Granger, Joseph Kromka, Andrew M Schneider

2020-Current year OA Pubs

A 2-stage protocol is standard of care treatment in the United States for chronic periprosthetic joint infection of the knee. While many patients benefit from insertion of an articulating spacer, there are instances in which this is not feasible, and a static spacer is indicated. However, many static spacer techniques risk instability and lack durability. The ideal static spacer construct should provide immediate brace-free weight-bearing to maximize function during the spacer stage and, if needed, permit delayed reimplantation in the case of medically high-risk patients. Here, we describe our surgical technique for a femoral nail and cement static spacer in …

Dynein Light Chains 1 And 2 Are Auxiliary Proteins Of Ph-Sensitive Kir4.1 Channels, Sun-Joo Lee, Jian Gao, Ellen Thompson, Jonathan Mount, Colin G Nichols

2020-Current year OA Pubs

Inward rectifier Kir4.1 potassium channels are abundantly expressed in cells that are important for electrolyte homeostasis. Dysregulation of Kir4.1 underlies various neurological disorders. Here, through biochemical and structural studies of full-length Kir4.1, we show that dynein light chain 1 and 2 proteins, also as known as LC8, copurify with Kir4.1 at stoichiometric levels. Direct interaction between Kir4.1 and LC8 is supported by in vitro binding assays and reiterated with native Kir4.1 proteins from mouse brain. Notably, we identify a LC8 binding motif in the unstructured N terminus of Kir4.1. Among Kir subtypes, the motif is unique to Kir4.1 and is …

Self-Collected Vaginal Specimens For Hpv Testing: Recommendations From The Enduring Consensus Cervical Cancer Screening And Management Guidelines Committee, Nicolas Wentzensen, L. Stewart Massad, Megan A. Clarke, Francisco Garcia, Robert Smith, Jeanne Murphy, Richard Guido, Ana Reyes, Sarah Phillips, Nancy Berman, Jeffrey Quinlan, Eileen Lind, Rebecca B. Perkins, Enduring Consensus Cervical Cancer Screening And Management Guidelines Committee

2020-Current year OA Pubs

OBJECTIVE: The Enduring Consensus Cervical Cancer Screening and Management Guidelines Committee developed recommendations for the use of self-collected vaginal specimens for human papillomavirus (HPV) testing in health care settings.

METHODS: A comprehensive literature search was performed, external systematic reviews were evaluated, and HPV genotype agreement between self-collected vaginal and clinician-collected cervical specimens was summarized. Recommendations considered available data, public comments, and expert consensus. Recommendations were ratified through a vote by the Consensus Stakeholder Group.

RESULTS: Clinician-collected cervical specimens are preferred and self-collected vaginal specimens are acceptable for primary HPV screening of asymptomatic average-risk individuals. Repeat testing in 3 years is …

The Role Of Androgens On Experimental Pain Sensitivity: A Systemic Review And Meta-Analysis, Elizabeth Wu-Chen, Gourav Banerjee, Elise Requadt, Benjamin Hunter, Thomas J. Baranski, Whitney Trotter Ross, Hadas Nahman-Averbuch

2020-Current year OA Pubs

Animal studies have shown androgens, especially testosterone, may have an analgesic effect on nociceptive behavior. However, it is unclear if this effect is present in humans. This review and meta-analysis aim to summarize and synthesize the role of androgens on experimental pain sensitivity in humans. Studies were included if they examined the (1) relationships between androgens and experimental pain sensitivity, (2) group differences in androgen or pain levels, and (3) the effect of androgen interventions on experimental pain sensitivity. After a comprehensive search, 31 papers were identified. When possible, meta-analyses were performed. Most studies examined the impact of testosterone on …

Thrombotic Microangiopathy After Kidney Transplantation: Insights Into Genetic Etiology And Clinical Outcomes, Massini Merzkani, Nyein Chann Wai Lynn, Karen Flores, Gaurav Rajashekar, Kristin Progar, Rowena Delos Santos, John P Atkinson, Daniel C Brennan, Anuja Java

2020-Current year OA Pubs

INTRODUCTION: Thrombotic microangiopathy (TMA), characterized by small-vessel thrombosis caused by endothelial injury, presents significant diagnostic and treatment challenges in kidney transplantation.

METHODS: To investigate the factors associated with posttransplant TMA, we conducted a retrospective study of 3535 kidney transplant recipients at our center from 2008 to 2023.

RESULTS: Sixty-eight patients were diagnosed with TMA, and 93% (63 of 68) underwent genetic testing. Patients were categorized into 3 groups based on the TMA etiology. Group 1 (

CONCLUSION: Our findings underscore the need for comprehensive pre and posttransplantation genetic testing to predict and manage the risk of TMA and prevent graft …