Digital Commons Network^™

A Phase 2 Randomized Trial Of Nbi-1065846 (Tak-041) In Patients With Anhedonia Associated With Major Depressive Disorder: Results Of The Terpsis Study, Shannon R Benedetto, Adrian Ionescu, Tingting Ge, Maura Furey, Swan Lin, Manish K Jha, Andrew Krystal, Asim A Shah, David P Walling, Neel Shah, Sakina J Rizvi, Sidney Kennedy, Antonio Laurenza, Venkatesha Murthy, Eiry Roberts, Jaskaran B Singh

Faculty, Staff and Students Publications

Background: Anhedonia is a core symptom of major depressive disorder (MDD) that may result from aberrant lateral habenula hyperactivity. Targeting G-protein coupled receptor 139 (GPR139) may improve anhedonia by modulating lateral habenula activity. NBI-1065846 is an investigational GPR139 agonist that improved anhedonia, anxiety, and depression in rodent models.

Methods: TERPSIS was a phase 2, proof-of-concept clinical study. Adults with MDD experiencing a major depressive episode with anhedonia were randomized 1:1 to NBI-1065846 or placebo for 8 weeks. The primary endpoint was the change in the Dimensional Anhedonia Rating Scale (DARS) score. Secondary endpoints were change in total Montgomery Åsberg Depression …

The Association Between Cardiac Vagal Activity And Urinary Catecholamine: Investigating The Effect Of Race And Sex, Li Shen Chong, Betty Lin, Elana B. Gordis, De Wayne P. Williams, Julian F. Thayer

Faculty Research, Scholarly, and Creative Activity

Black individuals are at greater risk for the development of cardiovascular diseases compared to White individuals. Autonomic nervous system (ANS) dysregulation has been identified as a significant risk factor contributing to racial disparities in cardiovascular disease, yet systematic racial differences that affect the measurement of ANS activity among White and Black participants are likely obscuring understanding about ANS-health disparity links. Moreover, sex differences in ANS activity have been observed. Thus, efforts to elucidate the comparability of ANS indices across race and sex are needed. This study aimed to investigate the effects of race and sex on the associations between two …

The Significance Of Blockchain Technology In Preserving Digital Evidence Integrity In Forensic Investigations, Marwa Popal, Ashfaq Ahmad, Muhammad Arshad

Research Outputs: 2025-Present

Digital forensics is the application of technology to the investigation and accounting of digital crime and the extraction and analysis of digital evidence from systems and networks. As the number of IoT [Internet of Things] devices has proliferated, the complexity inherent in forensic investigations has skyrocketed. While IoT forensics addresses the challenges of a lack of standardized security protocol and ensuring the integrity as well as security of evidence data, it brings to bear all the difficulties existing in classic forensics. Unfortunately, traditional digital forensic tools are generally inadequate in shielding that evidence from tampering or unauthorized access. Digital evidence …

The Double-Edged Role Of Cognitive Reappraisal: A Moderated Mediation Model Of Manager Support And Emotional Exhaustion Among Hotel Supervisors, Han Chen, Yvette Green

Journal of Global Hospitality and Tourism

Applying the Conservation of Resources Theory and the Affective Event Theory, this study explores the interplay between perceived manager support (PMS), negative emotions, and emotional exhaustion among hotel supervisors. The study also examines the moderating role of cognitive reappraisal strategy on the above relationships. Data were collected from a sample of U.S. hotel supervisors. Results showed that negative emotions play a mediating role in the relationship between PMS and supervisors’ emotional exhaustion. Cognitive reappraisal amplified the negative effect of PMS on negative emotions, the positive relationship between negative emotions and emotional exhaustion, and the indirect effect of PMS on emotional …

Customer Food Intake: An Empirical Analysis Of Gender, Restaurant Use And Attitude Toward Fast Food Among Adolescents And Young Adults, In Nairobi, Kenya, Gerishom G. Madivoli, Rosemarie Ayuma Khayiya, Beatrice Kamau

Journal of Global Hospitality and Tourism

Fast food is the fastest- growing food category worldwide, providing young people and adolescents with a quick, cost- effective, and easily accessible alternative to home- cooked meals. There has been considerably less research into how gender, restaurant usage, and attitudes influence patterns of fast- food consumption. Moreover, the growth of the fast- food industry in every nation creates a significant environmental impetus for increasing fast food consumption and promoting unhealthy eating behaviours. If this issue is not addressed, the prevalence of lifestyle diseases such as obesity, along with the costs of managing these conditions, will escalate, particularly in Kenya. This …

Reframing Service Quality In Ai-Powered Hospitality Environments, Olena Ciftci

Journal of Global Hospitality and Tourism

The hospitality and tourism industry is experiencing a technological shift through the integration of artificial intelligence (AI), transforming both guest experiences and service operations. While AI offers hyper-personalization, efficiency, and scalability, it challenges traditional notions of service quality rooted in human interaction. This viewpoint explores the emerging concept of tech-augmented hospitality, where AI and human employees co-create guest experiences. The paper highlights key research directions for reconceptualizing service quality in the era of AI-enhanced hospitality. It argues for the development of new evaluative frameworks that encompass hybrid service models, cultural adaptability, inclusivity, and AI literacy.

Preparing The Next Generation Of Health Education Teachers For The Ethical Use Of Ai, Melissa J. Haithcox-Dennis, Reeshemah Johnson

Journal of Research Initiatives

This article examines how health education teacher preparation programs can prepare future educators to use artificial intelligence (AI) in responsible and effective ways. It begins with a brief overview of the use of AI in education, considering the growing impact of generative AI technologies on teaching and learning. The article outlines international and national standards that govern the application of AI in education, addressing key ethical concerns, including the dissemination of inaccurate health information, violations of student privacy, bias, and inequitable access to AI tools. The article emphasizes the importance of ethical decision-making and professional responsibility when integrating AI into …

Stand For Support, Shatter The Silence: Administrative Approaches To Eradicate Bullying In Higher Education, Elaine M. Mora, Shawn P. Saladin

Journal of Research Initiatives

Bullying in higher education has become a widespread and complex issue that affects staff, faculty, and students worldwide, causing a detrimental impact on both psychological health and academic achievement. This paper provides a comprehensive examination of the phenomenon, encompassing all its manifestations, underlying causes, and significant consequences. The study, which draws on academic literature, outlines the various forms of bullying, including cyberbullying, mobbing, microaggressions, and social exclusion, and highlights the adverse effects these behaviors have on both individuals and academic communities. The research emphasizes how critical it is to comprehend the power relationships that exist in higher education settings and …

Multi-Generational Biases Perceived By Women To Senior Leadership Positions In Non-Profit Higher Education, Regina Watkins, Deanna R. Davis

Journal of Research Initiatives

Women remain underrepresented in senior leadership in both public and private industry and in non-profit postsecondary education. One reason that has been identified for the gender disparity in senior leadership positions is second-generation or implicit biases. The problem addressed in this study was the existence and persistence of second-generation biases that contribute to the lack of active senior women mentors, potentially inhibiting junior women from Generation X and millennials from achieving senior leadership status in non-profit higher education. The purpose of this qualitative descriptive case study was to gain a deeper understanding of the significance of perceptions of second-generation biases, …

Me, Myself, And Others: Emphasizing Identity Through Social-Emotional Learning As A Contributor To Adolescent Development, Marie Hall

Journal of Research Initiatives

Adolescence is a remarkable developmental period where figuring out who you are can feel essential. Relationships and sense of self are at the forefront during this period, as establishing a sense of connection can lead to positive social experiences that contribute to a myriad of benefits, ultimately facilitating positive life outcomes. School is often a central location for engagement, where relationships and a sense of self are explored, thereby serving as a primary social structure for youth. While adverse outcomes have been identified through this developmental period, school-based interventions that promote positive identity development and social connection have begun to …

Engaging Students And Stakeholders In Times Of Crisis: Hbcus Bridging Social Capital On Facebook While Navigating Physical Distancing, Pamela Peters

Journal of Research Initiatives

COVID-19 placed a strain on colleges that tend to rely on tuition, especially small HBCUs, which traditionally serve a high percentage of underrepresented students. Being away from campus, many stakeholders were experiencing higher levels of stress and anxiety. Social media offers an outlet for schools and stakeholders to stay connected during a crisis. Using social capital, this study examined how small HBCUs bridged social capital on Facebook during the year before and the first two years of the pandemic. A comparative analysis of Facebook posts of 30 HBCUs with a student population of under 2000 was conducted to determine post …

Khaled Hosseini’S Judgment In The Kite Runner Towards Pashtun And Hazara Identities, Bilal Waziri, Dawod Mangal, Kamaldeen Kamal

Journal of Research Initiatives

This book review offers a compelling examination of Khaled Hosseini's portrayal of Pashtun and Hazara identities in his acclaimed novel, *The Kite Runner*. Through a literary-ethnographic lens, the research delves into how narrative techniques can construct, amplify, or distort ethnic representations, particularly within the tumultuous backdrop of Afghanistan. The novel is scrutinized for its stark depiction of Pashtuns as oppressors and Hazaras as perennial victims, which risks perpetuating a simplistic and problematic singular narrative. Employing a library-based qualitative approach, this paper thoughtfully interprets textual evidence within the rich sociocultural and historical landscape of Afghanistan. The findings reveal that while the …

Students' Purchase Intention Of Street Food In Front Of De La Salle University - Dasmariñas Cavite, Patricia Jana J. Abeabe, Shanin S. Albios, Brent Louis C. Aure, Jimford U. Tabuyo

ICHRIE Research Reports

This study examined the factors that influence students' buying intentions for street food. A quantitative descriptive research design was employed to assess students' purchasing intentions toward street food in front of De La Salle University - Dasmariñas Gate 1. The study utilized convenience sampling, with 371 respondents consisting of undergraduate, masters, and doctoral students. Data were collected through an online survey using a Four-Point Likert Scale questionnaire. Statistical tools are weighted mean and Analysis of Variance (ANOVA) T-test. The findings revealed that perceived food quality and convenience significantly influenced students' buying intentions, while perceived food value also played a crucial …

Robust Ai Solutions For Financial Markets Through Generative Modeling, Dynamic Graph Learning, And Reinforcement-Based Portfolio Optimization, Jingyi Gu

Dissertations

Financial markets are inherently uncertain and dynamic, driven by complex factors such as macroeconomic signals, investor sentiment, and evolving inter-asset relationships. While machine learning has advanced financial modeling, existing approaches often fall short in addressing the real-world intricacies of finance. This dissertation confronts two critical challenges, human-driven stochasticity and risk-intensive decision-making under real-world trading constraints, while seizing a pivotal opportunity, the structural dynamics of evolving financial systems. These elements are foundational to advancing robust and practical financial intelligence.

To this end, this dissertation develops a unified framework for robust financial modeling and decision-making. The framework is architected as a progressive, …

Optimizing Hip And Knee Assistance For Walking And Sit-To-Stand Transitions: An Intrinsic Muscle Mechanics Based Predictive Approach, Neethan Ratnakumar

Dissertations

As the global population ages, the demand for wearable assistive technologies continues to rise, driven by their potential to enhance mobility and independence in older adults. Effectively designed controllers for lower-limb exoskeletons to assist sit-to-stand (STS) and walking are crucial for delivering efficient, safe, and comfortable assistance during daily activities. Traditionally, controller optimization involves biomechanical modeling and user-specific customization. Musculoskeletal simulations play a central role in this process by providing insights into human-exoskeleton interaction dynamics, thereby informing and refining control strategies.

This work presents a simulation-driven approach for developing exoskeleton controllers for walking and STS using two distinct methods: optimal …

Reasons For Cheating In Online Assessments And Strategies For Mitigating It: A Specific Study From The Perspectives Of English Language Teachers In Jeddah Governorate, Abdulelah M. Alqarni

Journal of King Abdulaziz University: Arts and Humanities

Assessment is one of the challenges facing online education, as academic integrity can be compromised due to students' cheating behavior. The current qualitative research sought to examine English language teachers' perceptions of the reasons why students cheat on online assessments. It also sought to find strategies to reduce cheating in these assessments. Thirteen teachers (seven males and six females) with at least five years of teaching experience in various secondary schools in the Jeddah Education Governorate participated in the study. Data were collected through semi-structured interviews and analyzed using MAXQDA software, version 2024. Data analysis revealed several reasons for cheating …

Doing Away With Racial Profiling In Policing Without Doing Away With The Rule Of Law, François Tanguay-Renaud

All Papers

Since the turn of the millennium, Canadian appellate courts have been investing increasingly systematic efforts in demystifying and curtailing racial profiling in policing. These judicial efforts have so far been focused on the application of the legal criteria for arrest and detention as well as their regulation under section 9 of the Canadian Charter of Rights and Freedoms. In this article, I contend that this unidimensional approach is unsound and outline a corrective path forward. First, I argue that the prevailing judicial understanding of what racial profiling is and how it affects the lawfulness of arrests and detentions has the …

Raising Provider Awareness Of Fluid Status In Women Undergoing Elective Cesarean Section Through The Use Of A Preoperative Checklist To Assess Fluid Status: A Quality Improvement Project, Marcus Miller, Michael Sorge

Doctor of Nurse Anesthesia Practice (DNAP) Manuscripts

Abstract

Maternal hypotension following neuraxial anesthesia during cesarean section is a common and potentially harmful complication. While vasopressors are often used for this issue, they carry risks to fetal well-being. Goal-directed fluid therapy (GDFT) provides an individualized approach that may improve outcomes by optimizing fluid status perioperatively. This quality improvement project aimed to increase provider awareness of fluid status through the implementation of a preoperative checklist that assessed fluid status in women undergoing cesarean section. A preoperative fluid assessment checklist was developed using evidence-based predictors of fluid status and integrated into anesthesia workflow. The project followed the Plan-Do-Study-Act cycle and …

Bridging The Gap: Harnessing Emerging Technology To Narrow The Academic Achievement Gaps Of Minority Students, Dionne Williams, Terence Vinson, Kristi Young, Danielle Williams, James R. Mixon

The Journal of the Research Association of Minority Professors

The academic achievement gap of Black, Hispanic, and Native American students has historically lagged as it relates to Caucasian students. This work defines academic achievement as standardized test scores, graduation rates, and college completion rates. The persistent educational disparities faced by minority students remain a significant challenge for school systems. The integration of technology offers a promising solution to help narrow these academic achievement gaps and provide equitable learning opportunities. Technology offers educators the ability to utilize self-paced instructional programming, ensuring that the educational needs and deficiencies of minority students are addressed. This work explores how innovative technological tools, ranging …

Transforming Education Through The Cohort Model In Graduate Schools Of Education, Kristi Young, James R. Mixon, Dionne Williams, Danielle Williams

The Journal of the Research Association of Minority Professors

The cohort model has emerged as a transformative approach in graduate schools of education for fostering a collaborative learning environment, providing professional networking opportunities, increasing community, and fostering a sense of belonging. This analysis is framed within Mead, Vygotsky’s, and Wenger’s theoretical framework on the interconnectedness of social interaction and cognitive development. Increased engagement, learning opportunities, promoting student success, enhanced leadership development, and improved program components are noted benefits of utilizing the cohort model in graduate schools of education. These authors noted some challenges to the cohort model, such as group dynamics and cohesion, diversity and inclusion, rigid structure, pressure …

Optimizing The Role Of Notaries In Digital Property Inheritance: A Comparative Legal Analysis, Tjhong Sendrawan, Rosa Agustina, Edmon Makarim, Arman Nefi, Josephine Rus Indra Sapti Ipfelkofer

Indonesia Law Review

One of the provisions in inheritance laws regarding the transfer of digital property after someone's death is a relatively new and evolving area of legal consideration. Inheritance laws were developed long before the widespread adoption of digital property, such as cryptocurrencies, non-fungible tokens (NFTs), online accounts, and other forms of digital property. As a result, existing inheritance laws often lack clear guidance on how to control the legal transfer of these digital assets upon the owner's death. This article aims to analyze the legal concept of digital property to be inherited and to provide solutions for current digital property inheritance …

Perceptions Of College Students With Learning Disabilities On High School Transition Services Related To Self-Determination Skills, Julie Ann O'Malley

Graduate Theses & Dissertations

This phenomenological qualitative study explored college students' recalled experiences with high school special education secondary transition programming and its impact on their college success and perceived readiness. Guided by Self-Determination Theory (SDT), focusing on the competence need, the research examined students' perceptions of instruction quality and quantity, and their preparedness in disability awareness and knowledge of strengths and limits.

Analysis of survey data and semi-structured interviews revealed key findings consistently showed students perceived high school transition services as inadequate in both quantity and quality. They reported a lack of formal instruction, including the absence of designated classes, a lack of …

2+2 Doesn't Always Equal 4: A Mixed Methods Approach To U.S.-Born Children Of Immigrants' Cultural Identities And Belonging, Teriin Lee

Dissertations

Within the next generation, one in five adults born in the United States will be a child of immigrants. Despite this, research on children of immigrants is limited. Specifically, the scholarship on this growing demographic limited their experiences to cultural identity, as it pertains to belonging. Simply put, the literature supposes that children of immigrants’ cultural identities define their sense of belonging. Moreover, the literature lacks insight into the lived experiences of children of immigrants, despite the increasing prevalence of this population.

This study aimed to address how children of immigrants experience cultural identity and belonging. A mixed methods research …

Enhancing Patient Outcomes: Developing A Comprehensive Database For Tracking Post- Dural Puncture Headache Incidence And Contributing Factors, Meredith B. Auge, Brittany Bogonovich

Doctor of Nurse Anesthesia Practice (DNAP) Manuscripts

Post-dural puncture headache (PDPH) is a debilitating complication following labor analgesia, often resulting from unintentional dural puncture (UDP). While national incidence is approximately 1.5%, institutional rates may vary due to provider experience, documentation practices, and patient factors. This Doctor of Nurse Anesthesia Practice (DNAP) quality improvement project aimed to improve identification and monitoring of UDP and PDPH through a revised tracking tool, retrospective review of 2024 data, and planning for an electronic registry. A multidisciplinary team of anesthesiologists, Certified Registered Nurse Anesthetists (CRNAs), Student Registered Nurse Anesthetists (SRNAs), and IT and quality specialists revised an existing tracking tool to better …

Quality Improvement Initiative For Emergency Cesarean Delivery: Implementation Of Rapid Sequence Spinal Anesthesia, Hunter L. Baselj, Joseph A. Gabster

Doctor of Nurse Anesthesia Practice (DNAP) Manuscripts

Abstract

Background: General anesthesia (GA) for emergency cesarean sections (EmCS) poses potential risks Rapid Sequence Spinal Anesthesia (RSSA) offers a promising alternative that preserves benefits of neuraxial anesthesia while accommodating the urgency of EmCS. This quality improvement (QI) project aimed to implement and evaluate the use of RSSA at a teaching hospital, utilizing a decision-tree tool to enhance clinical efficiency and assess provider perceptions regarding its impact on airway complications and post-operative pain outcomes. Methods: A RSSA decision-making chart was developed and introduced to anesthesia providers at a teaching hospital. A total of 16 providers, including CRNAs, SRNAs, and anesthesiologists, …

Towards A New Health Politics In Kenya: Labor Organizing And Strikes By Health Workers In The Public Health Sector, Michael Scanlon

Graduate Doctoral Dissertations

There has been insufficient attention by global health scholars to labor organizing by health workers, including when and why organizing occurs, what forms and strategies it takes and its implications for governance and policy. These questions are critical but largely absent in research on what has been called the “global health workforce crisis.” Kenya represents an important case study. A new constitution in 2010 expanded institutional spaces for labor organizing and decentralized governance of the health system. Both reforms had significant implications for the health workforce and strikes by health workers have been pervasive. In 2017, nationwide strikes by public …

The Role Of Intolerance Of Uncertainty In Prenatal Anxiety: Exploring Meta-Cognitive And Psychosocial Moderators, Jenna A. Macri

Graduate Masters Theses

Prenatal anxiety is common and has been linked to myriad adverse psychological and physical health outcomes for both the pregnant individual and the child. While research on factors contributing to the etiology and maintenance of prenatal anxiety is limited, intolerance of uncertainty has been identified as a key factor related to anxiety during pregnancy. The current study aimed to substantiate the role of intolerance of uncertainty in prenatal anxiety and explore meta-cognitive and psychosocial constructs as potential moderators of the relation between intolerance of uncertainty and prenatal anxiety. Additionally, due to inconsistencies in the operationalization of prenatal anxiety in the …

Effects Of Emotion Regulation On Reactions To Racism In Process Of Antiracism Among White Individuals, Stephanie Marando-Blanck

Graduate Doctoral Dissertations

The current study used multiple mediation models to explore the pathways and relationships among white privilege awareness, white emotional empathy, white cognitive empathy, white guilt, and different types of emotion regulation as predictors of individual and institutional antiracist engagement. Gaining an understanding of how white individuals experience and regulate certain racial emotions in the process of learning about their white privilege may inform antiracist trainings, diversity, equity and inclusion workshops, multicultural courses in schools, as well as counseling trainings in cultural humility. White adults (N = 170) were recruited through an online crowdsourcing platform (Prolific) and completed a brief (~20 …

Blackloving: The Culturally Responsive Engagement Practices Of Black Middle School Principals, Deandra L. Williams

Graduate Doctoral Dissertations

Black students are highly capable of learning and contributing to society when school communities are built on a foundation of love and there is meaningful school–family engagement. The purpose of this qualitative study was to examine how Black middle school principals engaged with Black families using BlackLoving culturally responsive family engagement practices as Black students transitioned from elementary to middle school in Boston Public Schools (BPS). The researcher employed Black Indigenous methodology, in the form of talking circles and memoing, to gather the stories of four former Black Boston public school principals (who were all men) and to explore their …

It's Deeper Than Rap. Exploring The Lived Experiences Of Black Faculty With Hip-Hop Epistemologies Through Counterstory, Austin Ashe

Graduate Doctoral Dissertations

This dissertation study explores the experiences of Black professors who carry Hip-Hop epistemologies and utilize Hip-Hop as a method to navigate the social and structural systems within their predominantly white institutions (PWIs). Grounded in Critical Race Theory, the study utilizes narrative inquiry and counterstorytelling. The analysis involved the development of a composite counterstory featuring the fictional protagonist, Hampton Franklin. The findings highlight common experiences among participants. Findings suggest that Black faculty are insiders whose positions grant them access and influence. Second, they are outsiders that navigate hypervisibility, invisibility, and racial battle fatigue. Third, each participant was a “pedagogue of the …