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The Church And Child Welfare: Exploring Faith-Based Support For Foster, Kinship, Adoptive, And Biological Families, Elizabeth Deagle Oct 2025

The Church And Child Welfare: Exploring Faith-Based Support For Foster, Kinship, Adoptive, And Biological Families, Elizabeth Deagle

Orphans and Vulnerable Children Senior Capstone

The child welfare system relies on foster, kinship, adoptive, and biological families to provide care, stability, and permanency for vulnerable children. Despite their critical role, these families often face complex challenges, including trauma exposure, placement instability, caregiver burnout, socioeconomic and legal barriers, and limited access to supportive resources. Historically, churches and faith-based organizations have played a significant role in caring for orphaned and vulnerable children. This paper examines the unique contribution of the church and faith-based organizations in strengthening child welfare efforts across three dimensions: (1) biblical and theological foundations for caring for vulnerable children and families, (2) trauma-informed ministry …


Ruthless: The Revolution Of Gangsta Rap, Laci D. Lavoy Oct 2025

Ruthless: The Revolution Of Gangsta Rap, Laci D. Lavoy

Theses

The popularization of gangsta rap in the United States was pivotal to the advancement of Black America following the close of the Civil Rights Movement. The ruthlessness of gangsta rap created a distaste of authority that became a catalyst for Black American unity and change. Artists quickly started writing songs that spoke out against issues plaguing Black and poor Americans, realizing the power of the microphone and the radio. These rappers created an awareness for White audiences that had not been present before and even created a space for White artists with shared experiences. Female rappers took this activism a …


Hr Newsletter, Minnesota State University Moorhead Oct 2025

Hr Newsletter, Minnesota State University Moorhead

HR Newsletter

No abstract provided.


Mechanisms For The Age-Related Increase In Fatigability Of The Elbow Flexor Muscles In Healthy Adults, Blaine E. Arney, Andrew Kuplic, Mitchell D. Adam, Christopher W. Sundberg, Sandra Hunter Oct 2025

Mechanisms For The Age-Related Increase In Fatigability Of The Elbow Flexor Muscles In Healthy Adults, Blaine E. Arney, Andrew Kuplic, Mitchell D. Adam, Christopher W. Sundberg, Sandra Hunter

Exercise Science Faculty Research and Publications

The mechanisms for the age-related increase in fatigability of the elbow flexor muscles during dynamic contractions are unknown. The purpose of this study was to determine the contribution of supraspinal and contractile mechanisms for the age-related increase in fatigability of the elbow flexor muscles. Twenty-eight young (23.2 ± 2.6 years; 14 females) and 32 older adults (72.6 ± 5.6 years; 15 females) performed 80 maximal velocity contractions at 20% of maximal isometric strength. Voluntary activation and muscle contractile properties were assessed before and immediately following the fatiguing exercise using transcranial magnetic stimulation (TMS) and electrical stimulation. Fatigability (% reduction in …


Using Gate And Key Systems To Engage Players With Varied Motivation Profiles, Wu Jin Oct 2025

Using Gate And Key Systems To Engage Players With Varied Motivation Profiles, Wu Jin

Level Design Theses and Dissertations

This study explores how literal gates and skill-based gates in level design can influence player behavior and align with different motivation profiles based on Nick Yee's Gamer Motivation Model [1]. The researcher created a single-player video game level using Dying Light 2, called "Electric Revival," to explore the appeal of literal gates and skill-based gates. The researcher expects that different types of players will exhibit distinct preferences for specific types of gates based on their motivation profiles, which align with their primary motivations. The researcher recruited 14 playtesters, of varying motivation types, to play the level and share their …


Peritoneal Immunosurgery: Immunotherapy Augmented Surgery For The Treatment Of Peritoneal Cancers, Ada I Ozcan, Arianexys Aquino López, Mary K Mckenna, Malcolm K Brenner, Alastair M Thompson Oct 2025

Peritoneal Immunosurgery: Immunotherapy Augmented Surgery For The Treatment Of Peritoneal Cancers, Ada I Ozcan, Arianexys Aquino López, Mary K Mckenna, Malcolm K Brenner, Alastair M Thompson

Faculty, Staff and Students Publications

Peritoneal malignancy often indicates disruptions in multiple physiological systems resulting from widespread cancer. The heterogenous origin and dynamic nature of peritoneal cancer make it difficult to treat with standard approaches that fit into guidelines. We describe how successful treatment should address the underlying pathology, the systemic response to surgical treatments and target the immune perturbations that facilitate the establishment and propagation of this multifaceted disease.


Hcmv Infection Of Terminally Differentiated Neurons Disrupts Microtubule Organization, Resulting In Neurite Retraction, Jacob W. Adelman, Andrew T. Sukowaty, Kaitlyn J. Partridge, Jessica E. Gawrys, Allison Akins, Scott S. Terhune, Allison D. Ebert Oct 2025

Hcmv Infection Of Terminally Differentiated Neurons Disrupts Microtubule Organization, Resulting In Neurite Retraction, Jacob W. Adelman, Andrew T. Sukowaty, Kaitlyn J. Partridge, Jessica E. Gawrys, Allison Akins, Scott S. Terhune, Allison D. Ebert

Biological Sciences Faculty Research and Publications

Human cytomegalovirus (HCMV) is a prolific human herpesvirus that infects most individuals by adulthood. While typically asymptomatic in adults, congenital infection can induce serious neurological symptoms, including hearing loss, visual deficits, cognitive impairment, and microcephaly in 10%–15% of cases. HCMV has been shown to infect most neural cells, with our group recently demonstrating this capacity in stem cell-derived forebrain neurons. Infection of neurons induces deleterious effects on calcium dynamics and electrophysiological function paired with gross restructuring of neuronal morphology. Here, we utilize an induced pluripotent stem cell-derived model of the human forebrain to demonstrate how HCMV infection induces syncytia, drives …


The Effect Of Self-Efficacy And Commitment On The Retention Of Alternatively Certified Teachers, Lydia V. Leduc Oct 2025

The Effect Of Self-Efficacy And Commitment On The Retention Of Alternatively Certified Teachers, Lydia V. Leduc

Doctor of Education (Ed.D)

Teacher attrition has opened the doors for professionals from other fields to enter the teaching field by following an alternative path. Yet, the attrition rate of these alternatively certified teachers (ACTs) is higher than that of traditionally certified teachers (TCTs). The objective of this transcendental phenomenological study was to examine the effect of self-efficacy and commitment on teacher retention of ACTs in Northwest Florida. The participants in the study worked in several schools in the area. After interviews, responses were evaluated, and categories and codes were compiled. Analysis was then done on the frequency and quality of response data to …


Fall Prevention In Home Care: The Introduction Of The Steadi Initiative As Evidence-Based Tool, Margarida Barbosa - Barreiro Oct 2025

Fall Prevention In Home Care: The Introduction Of The Steadi Initiative As Evidence-Based Tool, Margarida Barbosa - Barreiro

All Doctor of Nursing Practice (DNP) Scholarly Projects

Problem: Falls continue to be one of the leading causes of injury and mortality among older adults and remain a significant driver of healthcare utilization and cost. Within the home health setting, inconsistent practices in fall risk assessment and intervention have contributed to care gaps and increased patient vulnerability. The absence of a standardized, evidence-based process created the need for a structured quality improvement initiative to strengthen patient safety.

Aim of the Project: The purpose of this quality improvement project was to integrate the CDC’s Stopping Elderly Accidents, Deaths, and Injuries (STEADI) toolkit into home health visits to enhance the …


Montebello Islands Marine Sediment Retains Nuclear Weapons-Derived Radionuclide Contamination 70 Years After Detonations, Madison Williams-Hoffman, Mathew P. Johansen, Piers Larcombe, David P. Child, Michael A.C. Hotchkis, Oscar Serrano, Paul S. Lavery, Sangeeth Thiruvoth, Pere Masqué Oct 2025

Montebello Islands Marine Sediment Retains Nuclear Weapons-Derived Radionuclide Contamination 70 Years After Detonations, Madison Williams-Hoffman, Mathew P. Johansen, Piers Larcombe, David P. Child, Michael A.C. Hotchkis, Oscar Serrano, Paul S. Lavery, Sangeeth Thiruvoth, Pere Masqué

Research outputs 2022 to 2026

Three nuclear weapons tests were conducted in the 1950s at the Montebello Islands, an Indian Ocean archipelago in NW Australia. Anthropogenic radionuclides were introduced into the surrounding waters, where little quantification of the marine environment has occurred since. Here, we assess the distribution of anthropogenic radionuclides and plutonium (Pu) atom ratios in marine sediment throughout the Montebello Islands and the Western Australian (WA) coastline. Surface sediment was analysed for 90Sr, 137Cs, 238,239,240,241Pu and 241Am, alongside 240Pu/239Pu and 241Pu/239Pu atom ratios. The highest activity concentrations in sediment were from 239,240Pu, …


Identifying And Addressing Barriers To Long Term Follow Up Care Of Patients With Hepatitis C In A Rural Southern Appalachian Clinic, Sarah M. Brown Oct 2025

Identifying And Addressing Barriers To Long Term Follow Up Care Of Patients With Hepatitis C In A Rural Southern Appalachian Clinic, Sarah M. Brown

Doctoral Projects

This project addressed the issue of loss to follow-up (LTFU) among patients infected with hepatitis C virus (HCV), a significant barrier to achieving sustained virologic response (SVR) and improving outcomes. LTFU is particularly critical among marginalized and rural populations who face socioeconomic barriers, stigma, and other social determinants of health (SDOH) that affect treatment adherence. Grounded in the Social Ecological Model (SEM), this project examined systemic, community, interpersonal, and individual factors influencing LTFU (Ahmed et al., 2022; Al-Khazraji et al., 2019; Kilanowski, 2017).

This Doctor of Nursing Practice (DNP) quality improvement initiative sought to improve patient retention in HCV care …


Stochastic Modeling Of Electromagnetic Wave Propagation Through Extreme Dust Conditions In Underground Mines Using Vector Parabolic Approach, Emmanuel Atta Antwi, Samuel Frimpong, Muhammad Azeem Raza, Sanjay Madria Oct 2025

Stochastic Modeling Of Electromagnetic Wave Propagation Through Extreme Dust Conditions In Underground Mines Using Vector Parabolic Approach, Emmanuel Atta Antwi, Samuel Frimpong, Muhammad Azeem Raza, Sanjay Madria

Mining Engineering Faculty Research & Creative Works

Post-disaster underground (UG) mine environments are characterized by complex and rapidly changing conditions, adding extra attenuation to propagating electromagnetic (EM) waves. One such complex condition is the extreme generation of dust and sudden rise in humidity contributing to extra attenuation effects to propagating waves, especially under varying airborne humidity and dust levels. The existing wave propagation prediction models, especially those that factor in the effect of dust particles, are deterministic in nature, limiting their ability to account for uncertainties, especially during emergency conditions. In this work, the vector parabolic equation (VPE) model is modified to include dust attenuation effects. Using …


Strengthening Connections: Downtowns & Trails In Barrington, Nh, Shannon Rogers Ph.D., Nathaniel B. Bernitz, Patricia Prescott Oct 2025

Strengthening Connections: Downtowns & Trails In Barrington, Nh, Shannon Rogers Ph.D., Nathaniel B. Bernitz, Patricia Prescott

UNH Cooperative Extension

No abstract provided.


Teachers As First Responders: Transferring Trauma-Informed Strategies Into The Classroom, Lauren A. Daley-Norris Oct 2025

Teachers As First Responders: Transferring Trauma-Informed Strategies Into The Classroom, Lauren A. Daley-Norris

Doctor of Education (Ed.D)

Research suggests that nearly two-thirds of students experience a traumatic event by the age of 16 (Elmore et al, 2023; Wall, 2021). Despite this prevalence, a standardized training module for trauma-informed care (TIC) in K-12 education remains absent. Existing studies primarily focus on school or district-wide implementations (Avery et al, 2020; Champine et al., 2022; Plumb et al., 2016). The quantitative, quasi-experimental within-subjects repeated measures research design was used to address the study’s topic. Two research questions were formally stated to address the study’s purpose. Descriptive and inferential statistical techniques were used to analyze study data. Teachers (N = 12) …


Chemical And Sensory Attributes Of Different Ethanol Reduction Methods In Muscadine Wine Production, Alexandra A. Escalera, Patricia C. Patricio Morillo, Drew Budner, Katherine A. Thompson-Witrick, Andrew J. Macintosh Oct 2025

Chemical And Sensory Attributes Of Different Ethanol Reduction Methods In Muscadine Wine Production, Alexandra A. Escalera, Patricia C. Patricio Morillo, Drew Budner, Katherine A. Thompson-Witrick, Andrew J. Macintosh

Chemistry

There has been a recent shift in the global wine market towards reduced-alcohol wines. Muscadine grapes (Vitis rotundifolia) have become a popular choice in many emerging markets; however, their suitability in reduced-alcohol wine production has not been extensively tested. In this study, methods to reduce ethanol in muscadine wine were compared to determine differences in chemical and sensory attributes and consumer preference. The methods evaluated included full fermentation time with Saccharomyces cerevisiae (control), reduced fermentation time with Saccharomyces cerevisiae (stopped fermentation), fermentation with Saccharomycodes ludwigii yeast (instead of Saccharomyces cerevisiae), and vacuum distillation. The control and distilled wines were fermented …


Navigating Law And Taboo: Sexual Expression And Healthcare Access Among Tunisian Women, Serafina Sqatrito Oct 2025

Navigating Law And Taboo: Sexual Expression And Healthcare Access Among Tunisian Women, Serafina Sqatrito

Tunisia and Italy: Politics and Religious Integration in the Mediterranean

Women’s sexual health within Tunisia exists at an intersection between progressive legal frameworks, while also reversely experiencing modesty linked to gendered expectations, as well as enduring sexuality expression as a cultural taboo. This study aims to investigate how Tunisian women across generations understand as well as navigate intimacy, healthcare access, sexual education, sexual expression, within this complex social and legal context. Using a qualitative method, this study conducted four semi-structured interviews with women aged between 18-65 living in urban areas of Tunis and La Marsa. The interviews focused on experiences of shame and openness surrounding sexual life, societal sexual pressure …


Educational Mobility And Agency For Young Women In Rural Tunisia, Ruth Righi Oct 2025

Educational Mobility And Agency For Young Women In Rural Tunisia, Ruth Righi

Tunisia and Italy: Politics and Religious Integration in the Mediterranean

This paper examines the educational agency of young women in rural Tunisia, particularly in Djerba, exploring the paradox between high educational attainment and limited economic empowerment. Despite consistently outperforming male peers academically, university-educated Tunisian women face significantly higher unemployment rates and entrenched gender roles that dictate their mobility. The central question is the extent to which young women in rural Tunisia possess the agency required to realize their educational goals and how they balance traditional expectations with personal aspirations. Using a qualitative methodology, questionnaires were distributed in Arabic to a small sample of three university students in Djerba. Centering the …


Navigating Survival Without Rights: The Case Of Sub-Saharan And Sudanese Migrants In Tunisia, Amel Mohdali Oct 2025

Navigating Survival Without Rights: The Case Of Sub-Saharan And Sudanese Migrants In Tunisia, Amel Mohdali

Tunisia and Italy: Politics and Religious Integration in the Mediterranean

This study examines irregular migration and the lived experiences of migrants and asylum seekers in Tunisia, focusing on how individuals navigate prolonged transit in the absence of legal status, protection, and formal rights. Based on qualitative interviews with eight migrants from Sub-Saharan Africa, and Sudanese refugees displaced by mass violence, the research approaches migration not as a single act of movement but as an extended condition shaped by housing, employment, mobility, and access to safety. Across interviews, Tunisia is described as a transit country that unexpectedly became a site of residence due to expired visas, exit fines, and restricted onward …


Key Considerations For Department Mergers, Teshome Abebe Oct 2025

Key Considerations For Department Mergers, Teshome Abebe

Faculty Senate Reports

This white paper by Senator Abebe highlights key areas faculty and chairs should consider when discussing potential department mergers.


Assessing The Role Of Ocean Literacy In Liberia's Blue Economy : Pathway To Sustainable Blue Ocean Development In Liberia, Precious Tete Nah Oct 2025

Assessing The Role Of Ocean Literacy In Liberia's Blue Economy : Pathway To Sustainable Blue Ocean Development In Liberia, Precious Tete Nah

Ocean Sustainability, Governance & Management Dissertations

Ocean literacy involves understanding the fundamental concepts of the ocean's functioning, leading to informed and responsible decisions about the ocean. This understanding is vital for developing responsible ocean citizenship and implementing measures to sustain the ocean, as it highlights the ocean's influence on humans and the impact of human activities on it. Using a qualitative research method with a purposive sampling approach, the research asks focus group representatives from New Kru Town and Westpoint, both closed- and open-ended questions, on the importance of ocean literacy, challenges, prospects, and recommendations to promote sustainable blue ocean development.

The results of the research …


Growth Measurements In Ugandan Children With Sickle Cell Anaemia From A Hydroxyurea (Hydroxycarbamide) Treatment Trial Relative To Unaffected Sibling Controls, Dennis Kalibbala, Vincent Mboizi, Grace Nambatya, Susan Murungi, Joan Ashaba, Catherine Nabaggala, Lynnth Turyagyenda, Deogratias Munube, Phillip Kasirye, Robert Opoka Oct 2025

Growth Measurements In Ugandan Children With Sickle Cell Anaemia From A Hydroxyurea (Hydroxycarbamide) Treatment Trial Relative To Unaffected Sibling Controls, Dennis Kalibbala, Vincent Mboizi, Grace Nambatya, Susan Murungi, Joan Ashaba, Catherine Nabaggala, Lynnth Turyagyenda, Deogratias Munube, Phillip Kasirye, Robert Opoka

Paediatrics and Child Health, East Africa

No abstract provided.


Diffusion Of Innovation Of Port Decarbonization Measures : A Case Study Approach, Clint Rocky Mcculloch, Lucas Fernando Vaquero Roviriego Oct 2025

Diffusion Of Innovation Of Port Decarbonization Measures : A Case Study Approach, Clint Rocky Mcculloch, Lucas Fernando Vaquero Roviriego

Port Management Dissertations

The dissertation is a study of how stakeholders diffuse innovation in port decarbonization strategies through a case study approach, with emphasis on the Diffusion of Innovation (DOI) relating to the technical and operational measures in the developing regions. Port, being a critical hub in global supply chains, have to manage the increasing pressure of reducing greenhouse gas (GHG) emissions in alignment with International Maritime Organization (IMO) 2023 GHG strategy as well as the Paris Agreement. However, there is a gap in empirical research, specifically in non-European regions like South America and the Caribbean, highlighting the need for insights from stakeholders’ …


Gulf Coast Faculty Council Minutes - October 17 2025, Eric Saillant Oct 2025

Gulf Coast Faculty Council Minutes - October 17 2025, Eric Saillant

Gulf Coast Faculty Council Minutes

No abstract provided.


Assessment And Management Of Magnesium And Trace Element Status In Children With Ckd Stages 2-5, On Dialysis And Post-Transplantation: Clinical Practice Points From The Pediatric Renal Nutrition Taskforce., Jetta Tuokkola, Caroline E. Anderson, Sheridan Collins, Pearl Pugh, Molly R Wong Vega, Matthew Harmer, Lyndsay A. Harshman, Christina L. Nelms, Barry Toole, An Desloovere, Fabio Paglialonga, Nonnie Polderman, José Renken-Terhaerdt, Rukshana Shroff, Evelien Snauwaert, Stella Stabouli, Johan Vande Walle, Bradley A. Warady, Vanessa Shaw, Larry A. Greenbaum Oct 2025

Assessment And Management Of Magnesium And Trace Element Status In Children With Ckd Stages 2-5, On Dialysis And Post-Transplantation: Clinical Practice Points From The Pediatric Renal Nutrition Taskforce., Jetta Tuokkola, Caroline E. Anderson, Sheridan Collins, Pearl Pugh, Molly R Wong Vega, Matthew Harmer, Lyndsay A. Harshman, Christina L. Nelms, Barry Toole, An Desloovere, Fabio Paglialonga, Nonnie Polderman, José Renken-Terhaerdt, Rukshana Shroff, Evelien Snauwaert, Stella Stabouli, Johan Vande Walle, Bradley A. Warady, Vanessa Shaw, Larry A. Greenbaum

Manuscripts, Articles, Book Chapters and Other Papers

Children and young people with chronic kidney disease (CKD) are at risk for deficiency or excess of magnesium and trace elements. Kidney function, dialysis, medication, and dietary and supplemental intake can affect their biochemical status. There is much uncertainty about the requirements of magnesium and trace elements in CKD, which leads to variation in practice. The Pediatric Renal Nutrition Taskforce is an international team of pediatric kidney dietitians and pediatric nephrologists, formed to develop evidence-based clinical practice points to improve the nutritional care of children with CKD. PICO (patient, intervention, comparator, and outcomes) questions led the literature searches, which were …


Burdens Of Proof In Criminal Procedure, Eve Brensike Primus Oct 2025

Burdens Of Proof In Criminal Procedure, Eve Brensike Primus

Articles

The Supreme Court’s haphazard approach to allocating burdens of proof in criminal procedure has created a system in which constitutional rights can be rendered meaningless simply because defendants are required to prove things they cannot possibly know. Even though allocations of the burden of proof often drive litigation outcomes, the Court has failed to establish clear burden allocation structures for cases arising under the Fourth, Fifth, Sixth, and Fourteenth Amendments, leaving lower courts split about how to allocate the burdens. When the Supreme Court does allocate burdens, it often does so without explanation or consideration of key factors. Recent Supreme …


Changes In Antiviral Prescribing For Children With Influenza In Us Emergency Departments., Tess Stopczynski, Olla Hamdan, Justin Z. Amarin, James W. Antoon, Laura S. Stewart, Haya Hayek, James Chappell, Andrew J. Spieker, Eileen J. Klein, Janet A. Englund, Geoffrey A. Weinberg, Peter G. Szilagyi, John V. Williams, Marian G. Michaels, Julie A. Boom, Leila C. Sahni, Mary Allen Staat, Elizabeth P. Schlaudecker, Jennifer E. Schuster, Rangaraj Selvarangan, Ayzsa Tannis, Heidi L. Moline, Samantha M. Olson, Natasha B. Halasa Oct 2025

Changes In Antiviral Prescribing For Children With Influenza In Us Emergency Departments., Tess Stopczynski, Olla Hamdan, Justin Z. Amarin, James W. Antoon, Laura S. Stewart, Haya Hayek, James Chappell, Andrew J. Spieker, Eileen J. Klein, Janet A. Englund, Geoffrey A. Weinberg, Peter G. Szilagyi, John V. Williams, Marian G. Michaels, Julie A. Boom, Leila C. Sahni, Mary Allen Staat, Elizabeth P. Schlaudecker, Jennifer E. Schuster, Rangaraj Selvarangan, Ayzsa Tannis, Heidi L. Moline, Samantha M. Olson, Natasha B. Halasa

Manuscripts, Articles, Book Chapters and Other Papers

IMPORTANCE: Despite national recommendations, antiviral prescribing in emergency departments (EDs) for children at higher risk of severe influenza, such as those younger than 5 years and those with specific underlying conditions, remains low.

OBJECTIVE: To assess whether there were changes in antiviral prescribing for children at higher risk of severe influenza in academic pediatric EDs before the COVID-19 pandemic (2016-2020) vs the late pandemic period (2021-2023).

DESIGN, SETTING, AND PARTICIPANTS: This multicenter, cross-sectional study included influenza-positive children younger than 18 years presenting to the ED at 1 of 7 US pediatric academic hospitals participating in the Centers for Disease Control …


Leveraging De-Implementation Science To Promote Infection Prevention And Stewardship: A Roadmap And Practical Examples (Part Ii Of Ii), Westyn Branch-Elliman, Jennie H Kwon, Et Al. Oct 2025

Leveraging De-Implementation Science To Promote Infection Prevention And Stewardship: A Roadmap And Practical Examples (Part Ii Of Ii), Westyn Branch-Elliman, Jennie H Kwon, Et Al.

2020-Current year OA Pubs

De-implementation of established practices is a common challenge in infection prevention and antimicrobial stewardship and a necessary part of the life cycle of healthcare quality improvement programs. Promoting de-implementation of ineffective antimicrobial use and increasingly of low-value diagnostic testing are cornerstones of stewardship practice. Principles of de-implementation science and the interplay of implementation and de-implementation are discussed in part I of this Society for Healthcare Epidemiology of America White Paper Series.In this second part of the series, we discuss a process for applying principles of de-implementation science in infection prevention and stewardship and then review some real-world examples and case …


Chimeric Antigen Receptor Natural Killer (Car-Nk) Cells: From Preclinical Promise To Clinical Reality In Cancer Immunotherapy, Hunter Cassidy Cochran, Kevin Ashkan Ghobadi, Armin Ghobadi Oct 2025

Chimeric Antigen Receptor Natural Killer (Car-Nk) Cells: From Preclinical Promise To Clinical Reality In Cancer Immunotherapy, Hunter Cassidy Cochran, Kevin Ashkan Ghobadi, Armin Ghobadi

2020-Current year OA Pubs

Chimeric antigen receptor (CAR) natural killer (NK) cell therapy represents an emerging frontier in cancer immunotherapy. CAR-NK cells offer the potential for "off-the-shelf" treatments with a favorable safety profile, due in part to their innate capacity for HLA-unrestricted tumor targeting and an absence of graft-versus-host disease. Landmark clinical studies using cord blood - derived CAR-NK cells and another employing iPSC-derived CAR-NK cells have reported impressive response rates, durable remissions, and minimal toxicity. Furthermore, a growing landscape of ongoing clinical trials is exploring innovative strategies to enhance persistence, overcome solid tumor challenges, and prevent antigen escape. These advances collectively underscore the …


The Triglyceride-Glucose Index And Risk Of End-Stage Renal Disease Across Different Durations Of Type 2 Diabetes Mellitus: A Longitudinal Cohort Study, Mi-Sook Kim, Kyu-Na Lee, Jeongmin Lee, Jeongeun Kwak, Seung-Hwan Lee, Hyuk-Sang Kwon, Jing Hughes, Kyung-Do Han, Eun Young Lee Oct 2025

The Triglyceride-Glucose Index And Risk Of End-Stage Renal Disease Across Different Durations Of Type 2 Diabetes Mellitus: A Longitudinal Cohort Study, Mi-Sook Kim, Kyu-Na Lee, Jeongmin Lee, Jeongeun Kwak, Seung-Hwan Lee, Hyuk-Sang Kwon, Jing Hughes, Kyung-Do Han, Eun Young Lee

2020-Current year OA Pubs

BACKGRUOUND: This study investigated the association between the triglyceride-glucose (TyG) index, a marker of insulin resistance, and the risk of end-stage renal disease (ESRD) in individuals with type 2 diabetes mellitus (T2DM), focusing on variations by diabetes duration.

METHODS: We analyzed 1,219,148 Korean adults with T2DM from National Health Insurance Service data who underwent biennial health evaluations (2015 to 2016). ESRD was defined using specific procedural codes (V codes), and Cox proportional hazard models were employed to estimate hazard ratios (HRs) for ESRD across TyG index quartiles and diabetes duration categories, adjusting for various confounders.

RESULTS: Over 6,967,381 person-years of …


Microglia Regulate Gabaergic Neurogenesis In Prenatal Human Brain Through Igf1, Diankun Yu, Samhita Jain, Andi Wangzhou, Beika Zhu, Wenyuan Shao, Elena J Coley-O'Rourke, Stacy De Florencio, Jaeyeon Kim, Jennifer Ja-Yoon Choi, Mercedes F Paredes, Tomasz J Nowakowski, Eric J Huang, Xianhua Piao Oct 2025

Microglia Regulate Gabaergic Neurogenesis In Prenatal Human Brain Through Igf1, Diankun Yu, Samhita Jain, Andi Wangzhou, Beika Zhu, Wenyuan Shao, Elena J Coley-O'Rourke, Stacy De Florencio, Jaeyeon Kim, Jennifer Ja-Yoon Choi, Mercedes F Paredes, Tomasz J Nowakowski, Eric J Huang, Xianhua Piao

2020-Current year OA Pubs

GABAergic neurons are essential cellular components of neural circuits. Their abundance and diversity have increased significantly in the human brain, contributing to the expanded cognitive capacity of humans