Digital Commons Network^™

Physics-Guided Strategies For Enhancing Neural Networks Trained With Limited Data, Jose Guadalupe Perez Zamora

Open Access Theses & Dissertations

Deep neural networks excel at a wide range of processing tasks across various disciplines. However, the quantity and quality of data significantly impact network performance. In specialized domains, high-quality datasets are often difficult to gather, interpret, and curate for effective learning. Few-shot learning techniques, including transfer learning, data augmentation, and meta-learning, have emerged to address these constraints.

We propose three physics-guided strategies for enhancing neural networks trained with limited data: (1) combining existing models like LSTMs with Physics-Informed Neural Networks through two-branch architectures that merge their outputs, (2) deriving custom physics-informed data augmentation algorithms to expand limited datasets, and (3) …

Does Reducing Videofluoroscopy Frame Rate Affect Dige/St Grades In Modified Barium Swallow Studies?, Shitong Mao, Carla L Warneke, Sheila N Buoy, Ariana J Sahli, Brinda Rao Korivi, Carly E A Barbon, Kristy K Brock, Katherine A Hutcheson

Faculty, Staff and Student Publications

Understanding the effects of reduced frame rates on the reliability of Modified Barium Swallow (MBS) ratings for swallowing safety and efficiency is essential for clinical practice. While previous research has examined frame rate (simulated pulse rates) implications concerning penetration, aspiration, and residue ratings, the impact on summary grading systems like the Dynamic Imaging Grade of Swallowing Toxicity (DIGEST) remains unclear. This study analyzed a total of 315 full MBS videos collected from 278 patients, and 76.25% of patients were diagnosed with head and neck cancer (mean age 62.51 years, SD 8.53; 12.23% female). We performed pairwise comparisons of DIGEST grades …

Smags-Lasso: A Novel Feature Selection Method For Sensitivity Maximization In Early Cancer Detection, Hamid Khoshfekr Rudsari, Sara Khorami-Sarvestani, Johannes F Fahrmann, James P Long, Samir Hanash, Kim-Anh Do, Ehsan Irajizad

Faculty, Staff and Student Publications

Background: Sensitivity and specificity are foundational metrics for cancer detection tools. However, most machine learning algorithms prioritize overall accuracy during optimization, which fails to align with clinical priorities of early detection. We aim to develop a feature selection machine learning algorithm while maximizing sensitivity at a given specificity.

Methods: We developed SMAGS-LASSO, a machine learning algorithm that combines our developed Sensitivity Maximization at a Given Specificity (SMAGS) framework with L1 regularization for feature selection. This approach simultaneously optimizes sensitivity at user-defined specificity thresholds while performing feature selection. SMAGS-LASSO utilizes a custom loss function with L1 regularization and multiple parallel optimization …

Periostin Promotes Sarcoma Growth By Promoting Tumor-Associated Macrophage Migration And Differentiation, Jin-Fen Xiao, Kristin Ishaya, Emily Y Ko, Annaliese Fowler, Marina T Broz, Jlenia Guarnerio

Faculty, Staff and Student Publications

Soft-tissue sarcomas (STS) are characterized by abundant extracellular matrix (ECM) deposition, yet the functional contribution of specific ECM components remains poorly understood. In this study, we identify periostin (POSTN), a matricellular protein, as a regulator of sarcoma progression and the tumor immune microenvironment. Analysis of human sarcoma datasets revealed that high POSTN expression correlates with poor prognosis and elevated expression of ECM-related and myeloid cell–associated genes. In murine genetic models of sarcoma, tumors expressing high levels of Postn displayed enhanced expression of ECM genes and monocyte-recruiting cytokines. Functional silencing of Postnin vivo reduced tumor growth without altering tumor cell …

Experimental Design And Control Methods For Dose Rate Optimization In A Synchrotron-Based Proton Therapy Beamline, Jason Tang, Daniel Liu, Jacob Mathew, Sabrina Campelo, Lawrence Bronk, Paige Taylor, Yuting Li, Fada Guan

Faculty, Staff and Student Publications

Background: Ultra-high dose rate radiotherapy (typically defined >40 Gy/s) has shown promise for enhanced normal tissue sparing while maintaining tumor control, termed the FLASH effect when this biological response is observed. However, precise dose rate control remains a technical challenge in proton therapy systems, particularly for research applications investigating dose rate effects.

Purpose: To develop and validate a passive beam modulation technique using tungsten scatterers for controllable dose rate adjustment in a synchrotron-based proton therapy beamline without modifying accelerator parameters.

Methods: We investigated dose rate modulation using tungsten foils of varying thicknesses (0.1-3.5 mm) positioned upstream in an 87.2 MeV …

Activity-Dependent Transit Dose Assessment In 192ir High-Dose-Rate Brachytherapy Surface Applicator Using Gafchromictm Ebt4 Film, Daniel Liu, Emily Draeger, Christopher J Tien, Fada Guan

Faculty, Staff and Student Publications

Purpose: To characterize the newly released GafChromicTM EBT4 film for transit dose measurement in high-dose rate brachytherapy (HDR-BT) surface applicators and to systematically investigate the relationship between transit dose and 192Ir source activity.

Methods: EBT4 film was used to measure dose at 3 mm depth from a horizontally oriented Leipzig-style surface applicator connected to a 192Ir HDR-BT remote afterloading unit. Transit dose was systematically characterized across eight different source activities ranging from 3.372 to 9.716 Ci (13,724 U to 39,544 U) using measurements with seven nominal dwell times (5-100 seconds, scaled to 10 Ci (40,700 U)). Transit dose was derived …

Lymphodepletion, Tumor-Infiltrating Lymphocytes, And High Versus Low Dose Il-2 Followed By Pembrolizumab In Patients With Metastatic Melanoma, Merve Hasanov, Simin Kiany, Marie-Andrée Forget, Roland Bassett, Michael A Davies, Adi Diab, Jeffrey E Gershenwald, Isabella C Glitza, Jeffrey E Lee, Anthony Lucci, Jennifer L Mcquade, Sapna P Patel, Merrick I Ross, Hussein A Tawbi, Jennifer A Wargo, Michael K Wong, Chantale Bernatchez, Patrick Hwu, Cara Haymaker, Rodabe N Amaria

Faculty, Staff and Student Publications

This study evaluated the efficacy and safety of unengineered tumor-infiltrating lymphocytes (TILs) combined with pembrolizumab and either high (HD, Arm-1) or low (LD, Arm-2) doses of IL-2 in patients with metastatic melanoma (MM). Patients were lymphodepleted with cyclophosphamide and fludarabine, followed by TIL infusion and IL-2 (Arm-1: 720,000 IU/kg IV q 8 hrs up to 15 doses; Arm-2: 2 million IU SC for 14 days). Patients received pembrolizumab 200 mg IV starting 21 days post-TIL infusion, and every 3 weeks for up to 2 years. The primary endpoint was overall response rate (ORR) per RECIST 1.1. Blood samples were collected …

Normalization Of Temperature Effects For Quality Assurance Of Quantitative Prostate Apparent Diffusion Coefficient Imaging Across Multiple Sites, Ken-Pin Hwang, Joshua Yung, R Jason Stafford, Caroline Chung, Aradhana M Venkatesan

Faculty, Staff and Student Publications

Background: Apparent Diffusion Coefficient (ADC) as measured by diffusion weighted imaging is known to negatively correlate with prostate tumor aggressiveness. Heterogeneity in system and protocol performance causes potential variability in ADC acquired across a large scanner network, prompting a need to evaluate quantitative ADC from a prostate-specific MR diffusion protocol as part of quality assurance (QA). Due to the temperature dependence of ADC, repeatability and reproducibility assessments typically require phantoms to maintain a temperature of 0°C, imposing a considerable burden when assessing large numbers of scanners.

Purpose: To develop a QA procedure at room temperature for assessing the reproducibility of …

Addressing Controversy In Fusobacterium Nomenclature: What Exactly Does “F Nucleatum” Refer To?, Martha A Zepeda-Rivera, Floyd E Dewhirst, Susan Bullman, Christopher D Johnston

Faculty, Staff and Student Publications

The F. nucleatum group (sensu lato) is historically composed of four subspecies (F. nucleatum subsp. animalis, F. nucleatum subsp. nucleatum, F. nucleatum subsp. polymorphum, F. nucleatum subsp. vincentii). Although F. nucleatum sensu lato members are typically associated with oral disease, they have recently been shown to disseminate to the gastrointestinal tract and are associated with adverse health conditions such as inflammatory bowel disease and colorectal cancer (CRC). A growing debate over the nomenclature applied to Fusobacterium taxonomy has resulted in different names for these lineages, shifting them from their historic subspecies designations to …

Effect Of Focussing On Anastatica Hierochuntica Flower On Labour Pain, Duration Of Labour And Perceived Fatigue During Labour: Randomized Controlled Study, Emine Koç, Şükran Başgöl, Sümeyye Bal, Sabire Kirtiloğlu

Journal of Asian Midwives (JAM)

Background: Maternal fatigue and pain during labour can adversely affect the health of the mother, fetus, and newborn. Anastatica hierochuntica is a plant traditionally used in some cultures during childbirth rituals. When placed in water, the dried flower gradually unfolds and symbolically represents the opening of the uterus and birth canal. This study aimed to investigate the effect of focusing on the Anastatica hierochuntica flower during labour on labour pain, duration, and perceived fatigue.
Methods: This randomized controlled trial was conducted in the delivery unit of a mother-friendly hospital with 119 participants 60 in control group and 59 in intervention …

Factors Associated With Preterm Premature Rupture Of Membranes: A Case-Control Study In A Tertiary Hospital In Kabul, Afghanistan, Atia Sharif Nadi, Freshta Sharif Tawakkuli, Zainab Sharif Ezadi, Sayed Murtaza Sadat Hofiani, Shoaib Murtaza Sadat Naeemi, Ahmad Komail Frogh

Journal of Asian Midwives (JAM)

Background: It is essential to identify preterm premature rupture of membranes (PPROM) and its associated risk factors to reduce its impact. This study aims to find the demographic, reproductive, and obstetric factors associated with PPROM among women in Kabul, Afghanistan.
Methods: This case-control study was conducted over six months in 2023 at a tertiary hospital in Kabul, Afghanistan. We included 40 cases of PPROM and 80 controls without PPROM in this study. We used structured questionnaires to collect demographic, reproductive, and obstetric characteristics of the participants. To find the factors associated with PPROM, Logistic regression was performed using IBM SPSS …

The Effect Of An English Mother Tongue On Spanish Language Acquisition, Erin Wallace

Honors Theses

This study investigates how English influences the Spanish acquisition of English-speaking learners by analyzing written errors, background factors, and interview data. Using two linguistic classification frameworks, it identifies both the types and underlying causes of errors, revealing that gender and plural agreement issues, verb forms, word order problems, and subjunctive misuse are the most frequent difficulties. These errors primarily stem from first-language transfer, overgeneralization, and instructional gaps. The findings highlight the need for targeted practice, contrastive analysis, and greater exposure to authentic Spanish input. Despite limitations such as small sample size and incomplete interview participation, the study offers direction for …

A Story Of Life Through Death: An Osteobiography Of Two Individuals From The Late Saxon Period, Isabella Ragazzi

Honors Theses

The Anglo-Saxons were the most influential inhabitants of the British Isles in the years AD 450-1066, reigning during a time marked by much warfare, pestilence, and famine. Their impact on British history is still seen through archival materials as well as the archeological and bioarchaeological records. A recent development in the field of bioarchaeology is the osteobiography, which places skeletal analysis in context of the overall culture to create the most complete interpretation of the individual and their life history. Involving both traditional bioarchaeological evaluation and isotopic analysis, this method was applied to two Anglo-Saxon skulls donated to the University …

An Assessment Of The Relationship Between Stress And Glucose Levels In Medical Laboratory Science Students, Jayla Edwards

Honors Theses

Stress is prevalent among college students. Prolonged, unmanaged stress can affect physiological processes such as glucose metabolism. This study aimed to examine the effects of stress on glucose levels of medical laboratory science (MLS) students at the University of Southern Mississippi (USM). To achieve this, the participants’ perceived stress levels and glucose levels were measured at the beginning of the semester and during finals week, a period when college students typically experience the most stress. There were nineteen MLS students that participated. Data was collected at two phases: phase 1 at the beginning of the semester and phase 2 during …

Beyond The Classroom: The Role Of Cultural Capital In College-To-Career Transitions, Keynijah Sullivan

Honors Theses

For many college students, the transition into the workforce is shaped not only by academic knowledge, but also by access to less visible resources, often referred to as cultural capital. Research has been done in the past that discusses how cultural capital is transferred through families, its role in academic settings, and its impact on employability. However, there is a gap in research focusing on the role of cultural capital in college-to-career transitions. This study uses qualitative methods, specifically semi-structured interviews with junior and senior undergraduates at the University of Southern Mississippi. The purpose of this study is to better …

Nursing Students’ Attitudes Regarding Technical Standards For Entrance Into A Bachelor Of Science In Nursing Program, Jordyn Cook

Honors Theses

Admission into a Bachelor of Science in Nursing program requires students to meet specific criteria including a non-negotiable set of technical standards. Technical standards encompass physical abilities including twisting, bending, and handling objects of varying weights (Good Samaritan College of Nursing and Health Science, n.d.). While physical capabilities may hold significance in bedside nursing, the American Nurses Association does not establish specific physical qualifications (American Nurses Association, 2010). Due to admission criteria and technical standards, individuals with disabilities are rarely found among career nurses and nursing students (Leslie & Miller, 2020).

This study aims to determine nursing students’ attitudes towards …

Feasibility Of A Co-Designed And Personalised Intervention To Improve Vegetable Intake In Rural-Dwelling Young Adults, Katherine Mary Livingstone, Jonathan C. Rawstorn, Stephanie R. Partridge, Yuxin Zhang, Eric O, Stephanie L. Godrich, Sarah A. Mcnaughton, Gilly A. Hendrie, Kathleen M. Dullaghan, Gavin Abbott, Lauren C. Blekkenhorst, Ralph Maddison, Scott Barnett, John C. Mathers, Laura Alston

Research outputs 2022 to 2026

Background: This study determined the feasibility, acceptability, engagement and efficacy of a co-designed and personalised digital intervention to increase vegetable intake (Veg4Me) in young (18-to-35 years) rural-dwelling Australian adults. Methods: Participants living in rural Australia were recruited via local government networks and social media and randomised to receive 12-weeks’ access to personalised (intervention) or non-personalised (control) versions of the free Veg4Me web application. The intervention included: (1) personalised recipes, (2) geo-located food environment map, (3) healthy eating resources, (4) goal-setting portal, and (5) personalised e-newsletters. The primary outcome was feasibility (recruitment, participation, and retention rate). Secondary outcomes were user engagement, …

Impacts Of Dredging And Restoration On Sedimentary Carbon Stocks In Seagrass Meadows Of Pari Island, Indonesia, Yusmiana P. Rahayu, Gary A. Kendrick, Pere Masqué, Wawan Kiswara, Hadiwijaya L. Salim, Ali A. Lubis, Mathew A. Vanderklift

Research outputs 2022 to 2026

The effects of dredging and restoration on carbon sequestration in seagrass sediments is not well understood. Our knowledge is derived from few studies conducted in areas affected by dredging or restoration, the majority of which are from temperate regions. There is limited information available for tropical regions, where seagrass sediments can differ greatly in species composition, geomorphology, and hydrodynamic conditions. This study aims to assess the effects of dredging and seagrass restoration on sediment organic carbon concentrations and stocks at Pari Island, Indonesia. The results indicated that sediment organic carbon concentrations (%Corg) were higher in persistent seagrass meadows than in …

Fast And Accurate Measurement Of Small Field Dosimetry Using A Novel Scintillation Detector, Yiding Han, Jingzhu Xu, Yao Hao, Baozhou Sun

Faculty, Staff and Students Publications

Background: The most used instruments for small-field dosimetry have notable limitations, including the need for correction of output factors, limited scanning speeds, and challenges in alignment for percentage depth dose (PDD) measurements, particularly for extremely small fields. However, plastic scintillation detectors (PSDs) are an attractive alternative for small-field dosimetry due to their correction-free nature, linear dose response, and fast response time.

Purpose: This study evaluates the robustness and accuracy of the dosimetric measurements using a new water-equivalent PSD in small-field dosimetry. The study also aims to report accurate measurements of output factors, profiles, and an indirect method for measuring PDD …

Integration Of Fluorescence Imaging And Advanced Analytical Techniques For Reliable Contamination Detection, Mahsa Aliee

Theses and Dissertations

Effective surface contamination detection in food processing and healthcare environments is hindered by the limitations of visual inspection and ATP bioluminescence testing, both of which struggle to identify thin, transparent, or spatially irregular organic residues. These constraints contribute to inconsistent hygiene verification and create a need for objective, scalable, and real-time detection methods capable of operating under variable environmental conditions.

This dissertation develops an integrated framework that combines UV-induced fluorescence imaging with advanced analytical techniques to improve contamination detection reliability. A UV/UVC fluorescence imaging system was engineered with synchronized pulsed excitation (275 nm, 365 nm, 405 nm), adaptive exposure control, …

Resistance Through Policy: Documenting Lgbtq+ Advocacy In Public Education, Rhys Mitchell Fryar

Theses and Dissertations

This research examines how educational policies related to LGBTQ+ students are constructed, interpreted, and implemented across federal, state, and district-levels. It asks whether institutional intent reflects authentic commitment to equity or functions as symbolic compliance in politically contested environments. Using Portland Public Schools (PPS) as a case study, the analysis situates the district within Oregon’s affirming policy landscape and the Trump administration’s restrictive federal mandates. PPS has adopted policies, such as Administrative Directive 4.30.061 AD (2023b) and the Gender Identity Support Guide (2023a), to support queer and gender-expansive students; however, it faces a federal investigation (U.S. Department of Education, 2025b, …

Dynamic Wellbore-Integrity Framework For Post-Blowout Capping Of Offshore Wells, Abdelhakim Khouissat

Theses and Dissertations

In the aftermath of a blowout, a well undergoes a period of unrestricted fluid discharge (de facto primary recovery) followed by pressure buildup after its shut-in, which can adversely impact wellbore integrity. The quintessential example is Union Oil’s 1969 “A-21” well blowout in California’s Santa Barbara Channel, where seafloor-broaching incidents (oil “boilups”) kept taking place from the sides of the well following several failed well-capping attempts, until reservoir depletion eventually allowed a successful shut-in.Analytical and numerical reservoir depletion models are coupled with near-wellbore geomechanics to quantify yardsticks related to the post-blowout discharge utilized to indicate dangers for underground blowouts, in …

False Memory Susceptibility In Association With Attachment Theory: Effects On Memory Conformity, Rachel Catherine Miller

Theses and Dissertations

False memory research has been an evident topic in various fields of psychological study. Research in this area has important implications in forensic contexts and clinical settings as false memories can result in an array of harmful consequences. To explain individual differences in susceptibility to endorsing false memories of the rare medical procedure known as the voiding cystourethrogram (VCUG), the current study extended the findings of Herndon and colleagues (2014). It also examined predictor variables from attachment theory (such as attachment anxiety and avoidance), depressive symptomatology, compliance levels (e.g., use of confederates), and the impact of guided imagery (i.e., a …

Microbial Communities And Host Plants Of Megachilidae In The Greater Grand Forks Area (Ggfa), Sara Margit Wallace

Theses and Dissertations

Although Megachilidae are important pollinators in the United States, there is still much to learn about the health and functionality of these bees. Megachilids are threatened by competition from non-native pollinators and other environmental factors. The species distribution and composition of the gut microbiome in megachilid bees are not well known for the Greater Grand Forks Area (GGFA). My research seeks to answer the questions: what megachilid species are in the GGFA, where are they, and what symbionts are in their gut microbiomes? I collected and identified solitary bee specimens from North Dakota and Minnesota, dissected their gut contents, and …

Examining The Utility Of Haptic Feedback To Improve Pilot Situational Awareness & Performance: A Psychophysiological Approach, Jessica Van Bree

Theses and Dissertations

Pilot situational awareness (SA) has been deemed to be a critical component of flight efficacy, efficiency, and overall mission success. Studies have shown that several incidents and accidents have been the result of level-one SA errors, meaning that members of the flight crew have failed to accurately perceive the elements in their environments. As such, several strategies have been investigated to improve pilot SA. One potential avenue of research is the addition of haptics in to the flight deck. In some studies, the implementation of haptics have shown to improve piloting tasks, pilot safety, and aircraft control. The current study …

Data-Driven Evalutation And Optimization Of Fishbone Well Configurations For Geothermal Energy Recovery In The Red River Formation, Cedar Creek Anticline, Candace Proksch

Theses and Dissertations

This thesis evaluates the geothermal potential of the Red River C interval at the Cedar Creek Anticline and develops a workflow for screening fishbone multilateral designs in a heterogeneous carbonate reservoir. Regional heat-flow and depth maps delineated Cedar Creek as a thermally favorable site and the lower dolomite as the primary reservoir target, supporting construction of a 3D Petrel model that captured the five-member C-interval architecture, petrophysical properties, and temperature field. A multi-stage Particle Swarm Optimization and fast-marching framework used this model to generate and rank fishbone injector–producer configurations, and a line-source approximation combined with a fixed-efficiency Organic Rankine Cycle …

Identity Formation Through The Lived Experiences Of Immigrant Muslim High School Students, Badera Muhanna

Theses and Dissertations

The growing number of Muslim students enrolled in U.S. public schools necessitates a more comprehensive understanding of their unique experiences within their educational environments. This phenomenological qualitative study investigated Muslim students' perceptions of their lived experiences in a high school in the Northern Great Plains of the United States. Six Muslim students in their junior and senior years were selected to participate in semi-structured interviews. Through the lens of Bronfenbrenner’s ecological systems theory, this study aimed to deepen understanding of how Muslim students develop their sense of identity and the factors that contribute to this development. The findings revealed that …

Differential Microrna Profiling Of Blood L1cam And Bulk Extracellular Vesicles In Bipolar Disorder, Gabriel R Fries, Salahudeen Mirza, Jun Wang, Camila N C Lima, Wei Zhang, Marcela Carbajal Tamez, Giselli Scaini, Jair C Soares, Joao Quevedo

Faculty, Staff and Student Publications

Objective: This preliminary study aimed to identify microRNA (miRNA) signatures associated with bipolar disorder (BD) by profiling blood-derived extracellular vesicles (EVs) of both putative neuronal origin and from all sources.

Method: In two parallel studies of individuals with BD and controls (CON), we characterized miRNA expression profiles of blood EVs selected for L1CAM, a putative marker of neuronal origin (n = 20 BD/20 CON), as well as bulk EVs (n = 21 BD/20 CON). For each study, analyses identified miRNAs differentially expressed between groups, followed by functional interrogation and testing for associations with clinical features.

Results: Results of …

Application Of Plastic Waste As A Sustainable Bitumen Mixture—A Review, Nuha S. Mashaan, Thakur Chamlagai

Research outputs 2022 to 2026

Plastic waste is growing rapidly, while asphalt binders remain heavily reliant on petroleum bitumen. Incorporating recycled plastics into bitumen can divert waste and enhance pavement performance. This review compiles 251 experimental records from 56 studies to evaluate how plastic type, dosage, and processing conditions affect softening point, penetration, and viscosity. Across studies, plastics (PET, LDPE/HDPE/LLDPE, PP, and hybrids) consistently stiffen binders, reducing penetration and increasing softening point and viscosity, thereby improving rutting resistance while potentially raising mixing/compaction demands. Using grouped cross-validated machine-learning models (median baseline, ridge, random forest, XGBoost), we quantify the predictability of binder properties and show that nonlinear …

Biochar As Additive And Modifier In Bitumen And Asphalt Mixtures, Chathurika Dassanayake, Nuha S. Mashaan

Research outputs 2022 to 2026

Incorporating biochar into pavement materials is a novel and environmentally sustainable approach that aligns with global sustainability goals and advances greener pavement technologies. Studies have shown that biochar significantly enhances the strength, durability, and stability of pavements, while also contributing to sustainability by lowering the carbon footprint associated with traditional construction materials. Additionally, the incorporation of biochar contributes to the sustainability of asphalt engineering by reducing reliance on petroleum-based products and promoting the valorization of biomass. The primary objective of this review is to critically evaluate and synthesize existing research on the use of biochar in bitumen and asphalt mixtures, …