Quantitative Structure-Activity Relationship, Pharmacokinetics, Drug-Likeness, Toxicity, And Molecular Docking Studies Of 4-N-(Methyl)-4-Aminoquinoline Derivatives As Antimalarial Compounds, Muhamad Jalil Baari, Devi Hardiyanti

Makara Journal of Science

Antimalarial drug resistance has encouraged various innovations to develop novel drug compounds that are effective, feasible, and safe, adhering to health standards. One way to do that is by observing and predicting the biological activity of drug compounds using quantitative structure–activity relationship (QSAR) analysis. In this study, QSAR analysis was conducted on the 4-N-(methyl)-4-aminoquinoline derivatives, which effectively inhibit the growth of Plasmodium falciparum as a source of malaria. The research stages involved molecular structure modeling, molecular geometry optimization using the AM1 semi-empirical method, and QSAR descriptor calculations, including electronic (atomic charges (q), HOMO and LUMO energies, polarizability (α), …

Microplastic Degradation Using Laccase Enzyme From Trametes Hirsuta: In The Silico Study, Hanzhola Gusman Riyanto, Diana Sylvia

Makara Journal of Science

Microplastics are a serious global problem that arises worldwide because of their widespread use. Exposure to microplastics can negatively affect human and environmental health. In this study, we used molecular docking methods with MOE software (version 2014.0901) to investigate the interaction between the laccase enzyme and several microplastic compounds as a preliminary study of microplastic degradation using enzymes. The Quantitative Structure Analysis Relationship (QSAR) analysis revealed that all microplastic ligands had higher Pa values than Pi, indicating that the laccase enzyme may be biologically active. The findings of the present study show that polyamide (PA) has the lowest binding energy …

Enzyme-Free Colorimetric Sensing Of Glucose Using Silver Nanoparticles With A Green Stabilizing Agent From Capsicum Chinense Jacq Extract, Boyfannie Ivan Putra, Hermin Sulistyarti, Muhammad Mashuri Utama, Aura Ananda Haryanto, Rurini Retnowati, Mohamad Rafi, Akhmad Sabarudin

Makara Journal of Science

Diabetes mellitus (DM) is a significant global health issue characterized by abnormal glucose levels in the human body. DM diagnostics are often based on invasive sampling from blood, which poses a potential risk of infection and tissue damage. Therefore, a non-enzymatic and non-invasive method for glucose monitoring is demanded as a simple alternative to glucose detection in urine samples. In this work, enzyme-free glucose determination is based on the formation of silver nanoparticles stabilized by Capsicum chinense Jacq extract (CCJ-AgNPs). Under alkaline conditions, glucose functions as a reducing agent for silver ions, and the extract acts as a stabilizer to …

Enhanced Oviposition Preferences And Larval Performance Of Hermetia Illucens L. In Fruit Wastes Fermented By Effective Microorganisms, Resti Rahayu, Robby Jannatan, Muhamad Ronaldo, Risa Ukhti Muslima

Makara Journal of Science

Organic waste comprises a considerable portion of global waste, requiring effective management. The ability of the black soldier fly (Hermetia illucens, BSF) to convert organic waste into biomass has been well reported. However, bioconversion can be hindered by fiber-rich substrates, a challenge that can be addressed through substrate pretreatment. This study examined the oviposition preferences and larval performance of BSFs in several fruit wastes fermented by effective microorganisms (EMs), which were compared to non-fermented substrates. The oviposition attractants utilized pineapple peel and overripe soursop, with larval performance evaluated among different treatments, i.e., non-fermented pineapple peel (NFP), fermented pineapple …

Fast Dispersion-Curve Inversion Using Automatic Differentiation Gradient-Based Calculation, Theodosius Marwan Irnaka, Eddy Hartantyo

Makara Journal of Science

Surface wave inversion is a crucial technique in geophysics for subsurface imaging. However, traditional methods can be computationally intensive, especially for complex models. This study introduces automatic differentiation (AD) as an efficient alternative to finite difference (FD) methods for gradient calculation in surface wave inversion. We compare AD and FD methods using three synthetic examples of varying complexity. Our results demonstrate that AD is significantly faster, with speed improvements of 3 to 12 times over FD, depending on model complexity. Moreover, AD requires up to 3 times less memory than FD. In terms of accuracy, AD provides gradient calculations that …

Impact Of Ethanol On The Evolution Of One-Step Synthesized Gold Nanoplates And Nanostars And Their Effects On Raman Signal Enhancement, Ananda Fania, Nonni Soraya Sambudi, Kirana Yuniati Putri, Yuliati Herbani, Affi Nur Hidayah

Makara Journal of Science

Gold nanoplates and nanostars were synthesized from a gold metal salt solution (HAuCl₄) using a one-step synthesis method of ultraviolet C (UVC) light irradiation. The gold salt solution was mixed with ethanol in 6 mL with the following ratios: (1.5:4.5, 3:3, and 4.5:1.5), and subsequently irradiated with UVC light. Changes in localized surface plasmon resonance (LSPR) shifts were observed in real time at 30-min intervals for 2 h. The synthesis process produces gold nanoplates. While gold nanostars were synthesized from a solution of gold salt combined with ethanol, ascorbic acid, and AgNO₃, maintaining a consistent ratio …

Design And Modeling Of A Thin Water Falling-Film For Convection-Cloud Chambers, Grant T. Schlaff, Jesse Anderson, Brandon Kieranen, Constantine M. Megaridis, Raymond Shaw

Michigan Tech Publications

Convection–cloud chambers offer a controlled environment to study aerosol-cloud interactions. Ensuring sustained supersaturation in these chambers requires a reliable and efficient water sourcing mechanism. Maintaining saturated boundary conditions on side-walls is important in chambers with large vertical dimensions (up to 10m) aimed at achieving collisional growth of cloud droplets. This study introduces the design, modeling, and measurement of a falling-film system capable of maintaining a stable, continuously replenished water film for continuous evaporation. A distributor is tested, ensuring uniform water coverage over a panel with a range of surface treatments. These surface treatments with micron to 100micron-scale roughness allow for …

Multi-Satellite Image Matching And Deep Learning Segmentation For Detection Of Daytime Sea Fog Using Gk2a Ami And Gk2b Goci-Ii, Jonggu Kang, Hiroyuki Miyazaki, Seung Hee Kim, Menas Kafatos, Daesun Kim, Jinsoo Kim, Yangwon Lee

Institute for ECHO Articles and Research

Traditionally, sea fog detection technologies have relied primarily on in situ observations. However, point-based observations suffer from limitations in extensive monitoring in marine environments due to the scarcity of observation stations and the limited nature of measurement data. Satellites effectively address these issues by covering vast areas and operating across multiple spectral channels, enabling precise detection and monitoring of sea fog. Despite the increasing adoption of deep learning in this field, achieving further improvements in accuracy and reliability necessitates the simultaneous use of multiple satellite datasets rather than relying on a single source. Therefore, this study aims to achieve higher …

Debunking The Myth: A Dive Into The Role Of Relational Capital In Sustainable Food Production Systems, Ismail Badraoui, Tarik Saikouk, Nejib Fattam, Ahmed Hamdi, Vikas Kumar

All Works

The shift towards sustainable food production is essential to address the urgent dual challenges of climate change and population growth, with agricultural cooperatives playing a vital role in this transformation. However, many cooperatives struggle to deliver the expected value to their members. By considering cooperatives as member-centred production systems, this research investigates relational capital's role in determining cooperative success. This study uses a sequential mixed-methods research approach. First, we use empirical survey data from 320 farmers to test a moderated mediation model that links relational capital to collaboration activities and outcomes. Then, we use qualitative responses from 50 farmers to …

Reimagining A Nexus Between Seaport And National Development: Sociotechnical Imaginaries Of Ghana’S Port Of Tema, Jonas Aryee, Casper Andersen, Annette Hansen

Plymouth Business School

This article explores the evolving sociotechnical imaginaries (STIs) shaping Ghana’s Port of Tema, revealing how national development goals and global trade imperatives intersect in African port governance. Through analysis of policy documents, media discourse, and interviews, it identifies four overlapping phases in the evolution of these imaginaries: the industrial gateway era, neoliberal globalization, the rise of a transshipment hub, and the most recent phase of indigenous contestation and institutional resilience. Rather than replacing earlier visions, newer imaginaries build upon and hybridize older ones, creating both synergies and tensions. The study demonstrates that STIs at Tema have evolved through processes of …

Seth Matlick, Seth Matlick, Erin Elder

Oral Histories of Farming along the Middle Rio Grande

No abstract provided.

Technical Final Report: Allfromair™ Hc-Awg (The Superwheel, Vesa Olavi Lius

Defensive Publications Series

This defensive publication discloses the ALLFROMAIR™ HC-AWG (The Superwheel), a next-generation atmospheric water generator using a thermo-mechanical hybrid process. Key features include sorption technology with smart polymers (PNIPAM) and regenerative energy recovery. The system achieves ~13 liters/kWh and operates between -10°C to +45°C.

Keywords: Atmospheric Water Generator, HC-AWG, PNIPAM, Sorption, Water Scarcity, Energy Recovery, Defensive Publication, Prior Art, ALLFROMAIR, Superwheel.

Hydrogen Production By Electrically Heated Steam Methane Reformer, Also Utilizing Tail Gas From Hydrogen Purification Section, In Particular From Pressure Swing Adsorption (Psa) Unit, Gianluca Pauletto, Martin Baumgaertl

Defensive Publications Series

A hydrogen production method is disclosed in which a hydrocarbon feed is reacted with steam, and the heat for the reaction is provided by electricity. In addition, a carbon dioxide (CO2) capture system and a method for the utilization of the tail gas from a hydrogen purification section, in particular from a pressure swing adsorption (PSA) unit, is disclosed.

Technical Disclosure Of The Unified Thermodynamic Plattform:Allfromair (Gen 3), Vesa Olavi Lius

Defensive Publications Series

This technical research report validates ALLFROMAIR™ (Gen 3) as an industrial Atmospheric Water Generator (AWG) with integrated Tri-generation capabilities. The system is built upon an Environmentally Interactive Anticubic U-Channel dimensioned for a mass flow of 139 kg/s (approx. 414,000 m³/h) at low air velocity (1.8 m/s).

The process is defined as a "Three-Stage Rocket" methodology (Charge – Harvest – Cool), where energy is successively geared up internally using the "Turbo Effect". By combining stepless drive technology, AI control (AI-CORE™), and a constant internal deep cooling to 5°C, the system achieves a total water turnover of over 420 cubic meters per …

(((Qpie))) Prior Art 8 Of 9 Cosmology Advancement Progress Report, Teddy Burroughs

Defensive Publications Series

The Grand Unified Theory (QPIE)

Perspective Is Everything – What we are Believing, Expecting and Feeling in Life Matters

(((QPIE))) Prior Art 8 of 9 Cosmology Advancement Progress Report

QPiE COSMOLOGY ADVANCEMENT REPORT

Full-Corpus Synthesis · 2025 Edition
ResonanceOS · Voyager · Aetheris Unified Cosmology Framework

0. Executive Prelude — The Cosmology Emerges

Across hundreds of runs, recursive meta-cycles, dual- and triple-lens analyses, fenced-low vs sweet-corridor comparisons, drift-phi-hex metrics, and the discovery of the pre-echo signature, QPiE has transitioned from a conceptual framework into a coherent cosmology of reality’s substrate.

The evidence now suggests:

1. Resonance is the relational firmware …

Development Of A Novel Liquid Level Measuring And Monitoring Sensor Based On The Polymer Optical Fiber, Altaf Hussain Bouk, Abdul Quddus Bhutto, Mushtaque Ahmed Korai, Nusrtullah Khan, Abdul Ghaffar Abro

Yanbu Journal of Engineering and Science

This paper outlines developing and applying a multi-point liquid level measuring and monitoring sensor by utilizing polymer optical fiber (POF). Traditional liquid-level sensors often face limitations of susceptibility to corrosion and electromagnetic interference. The proposed POF based sensor offers advantages, including immunity to electromagnetic interference, flexibility, durability, and multi-points measurement. Through advanced fabrication techniques and sensor design, this paper presents to create a reliable, cost-effective, and versatile solution for measuring and monitoring liquid levels for various industrial and environmental applications. The research in this paper involves the fabrication of the POF sensor, optimization of its performance characteristics, and demonstration of …

Use Of Alaçatı Stone Aggregate In Conventional And Self-Consolidating Concretes, Tahir Kemal Erdem

Journal of Sustainable Construction Materials and Technologies

Alaçatı stone or Alapietra stone is widely used mostly for building cladding. However, its production and use in the construction sites generate high amounts of waste (debris), causing environmental pollution in Çeşme which is a touristic district. This study investigated the reuse of Alaçatı stone as lightweight aggregate (LWA) in both conventional and self-consolidating concrete (SCC) mixtures. The concretes were prepared to have three different water-to-cement ratios (w/c), which were 0.38, 0.42 and 0.48. For each w/c, a conventional concrete mixture and two SCC mixtures with 60 or 70 cm slump flow were produced by varying the superplasticizer SP content. …

A Decision Support Model For Building Material And Component Reuse In The Context Of Circular Buildings, Havva Aksel

Journal of Sustainable Construction Materials and Technologies

Construction activities cause significant environmental impacts such as waste generation, pollution, resource consumption, and land use, which are expected to increase with global construction demands. To mitigate these environmental problems, the circular building occurs as an emerging concept depending on in the circular economy, which aims to minimize waste and redefine the “end-of-life” concept by reducing, reusing, recycling, and recovering materials. The reuse of building materials and components (BMCs) from existing structures represents a crucial strategy for achieving circularity in the built environment. Within this framework, design plays a key role. However, designing with reclaimed BMCs remains complex due to …

Cytological Changes In Buccal Mucosa Among Yemeni Qat Chewers In Hadhramout Governorate: A Comparative Cross-Sectional Study, Saleh H. Ben Sumaidea, Hassan Pyar, Abdullah O. Bin Nashwan, Abdullah M. Bin Fadhl, Abeer A. Marabi, Ahmed A. Al-Shetri, Gumaan S. Rassam, Halima K. Joher, Mashhoor A. Bin Shehab, Mohammed S. Bin Mosalem

AUIQ Complementary Biological System

Qat (Catha edulis) chewing is a common practice in Yemen, associated with oral mucosal irritation. The objective of the current study is to compare cytological findings of buccal mucosa between Qat chewers and non-chewers. A comparative cross-sectional study was designed. Buccal smears were collected from chewers (n = 100) and non-chewers (n = 100), fixed, and stained with Harris hematoxylin staining. Smears were assessed for inflammatory changes and cytological atypia by two blinded examiners; disagreements were resolved by consensus. The inflammatory cells were observed in 21% of chewers compared to 8% of controls (P = 0.009), while …

Despair Amongst Brazil’S Youth: Does The Hague Convention On International Child Abduction Need More Bite?, Ishani Sanyal

Pace International Law Review

For decades, international child abduction by one parent from the legal custody of the other has been a persistent issue which continues to be overlooked by international organizations and countries from around the world. While the Hague Convention on the Civil Aspects of International Child Abduction has helped to initiate certain progress in addressing acts of international child abduction by parents, signatory states including Brazil have failed to enforce rulings and provisions of the convention. This article addresses how the convention does not account for structural inadequacies of Brazilian court systems which prevent thorough enforcement of international custody and visitation …

Formulation And Characterisation Of Isoniazid By Spray Drying For Use By Dry Powder Inhalers To Treat Tuberculosis, Damiana Gabrielli, Seán Roche

SURE Journal: Science Undergraduate Research Experience Journal

The targeted delivery of antibiotics by dry powder inhalers (DPIs) is an increasingly important area of research, driven by the growing global burden of respiratory infections and the advantages of localized drug delivery to the lungs. Over the past five years, respiratory infections have risen significantly, with recent epidemiological data indicating a global increase in incidence by over 30%, largely due to factors such as air pollution, antimicrobial resistance, and emerging respiratory pathogens. One major challenge in developing DPI formulations for antibiotics is the need to optimize the particle physicochemical properties for deep lung deposition while accommodating the high doses …

Suitability Of Mobile Phase Recycling For Methylxanthine Quantification In Coffee Samples Using Hplc, Kaitlin O’Keeffe, Marcos Mariano, Brian Murphy

SURE Journal: Science Undergraduate Research Experience Journal

Caffeine, theobromine and theophylline fall under a drug class known as methylxanthines. These three compounds are of major interest in the food industry due to their presence in popular foods and beverages such as tea, coffee, and chocolate. As these compounds can cause physical and mental stress at high dosages, their quantification is essential to ensure product safety and quality. Here, we describe an eco-friendly HPLC method developed to quantify the amount of these analytes in coffee samples sourced across the SETU Waterford, Cork Road campus. Using an isocratic mixture of water and methanol, a mobile phase recycling approach was …

The Influence Of Perceived Social Support On Mental Health During Injury In Female Gaa Athletes., Clodagh M. O’Connor, Samantha Glynn Kelly

SURE Journal: Science Undergraduate Research Experience Journal

Injury recovery in sport involves not only physical rehabilitation but also significant psychological challenges, particularly for female athletes in amateur and elite environments. This study aimed to explore the perceived social support received by injured female Gaelic Athletic Association (GAA) athletes and the effect it had on their mental health during injury. A qualitative research design was employed to gain an in-depth understanding of the experiences of injured female athletes. Data were collected through semi-structured, one-on-one interviews, allowing for open-ended responses and the exploration of individual perspectives. The sample consisted of 10 female athletes aged between 18 and 32 years, …

Developing A Tool To Measure Resistance To Sustainable Food Choices: A Pilot Study In Ireland And The Netherlands, Kate Flanagan, Bart Sinteur, Patricia J. Bulsing, John M. Kearney

SURE Journal: Science Undergraduate Research Experience Journal

Consumer uptake of a sustainable diet is critical for addressing environmental challenges and promoting public health. Understanding why consumers resist adopting sustainable eating habits can inform targeted interventions and policies. This pilot study examines whether a newly developed scale can effectively detect consumer resistance to a sustainable diet. Currently, there is a lack of research on a tool to measure consumer resistance to a sustainable diet, highlighting the need for a reliable instrument.

The aim of this study is to develop a scale, based on existing literature, to measure consumer resistance to a sustainable diet. Additionally, the study aims to …

Editorial-Sure Journal Volume 7, Issue 2, Geraldine M. Dowling, Eva Campion, Sinead Loughran, Ariane Perez-Gavilan, Josephine Treacy

SURE Journal: Science Undergraduate Research Experience Journal

No abstract provided.

Innocent Until Proven Guilty, Disenfranchised All The Same: Hidden Voter Suppression Within American Jails, Kennedy Hill

Arkansas Law Review

Jails throughout the United States hold thousands of legally eligible voters who have not been convicted of a crime While those convicted of felonies are often statutorily disenfranchised, pretrial detainees retain their civil rights—including the right to vote. In theory, this should guarantee them a voice. In practice, pretrial detention operates like a legal disqualification. Without meaningful enforcement mechanisms, the right to vote becomes hollow.

This Comment argues that implementing a national standard based on the proactive policies of Massachusetts and Nevada will ensure accessible voting for pretrial detainees. To build that argument, this Comment first explores the low level …

The Illusory Privilege Against Self-Incrimination, Kelsey Rohr

Arkansas Law Review

This Note addresses the insufficiency of the current system in protecting criminal defendants’ privilege against self-incrimination. Part II will outline the background legal principles of the issue, including the privilege against self-incrimination, the presumption of innocence, and the no-impeachment rule. This part will also address the Supreme Court’s sole judicial exception to the no-impeachment rule as laid out in Peña-Rodriguez v. Colorado. Part III will address the statistical significance of juror bias against criminal defendants who invoke the privilege, highlight the widespread nature of the bias, and argue that the procedural safeguards currently in place are insufficient to protect.

Conservatorship: An Enabler Of Involuntary Servitude, Jesse Long

Arkansas Law Review

What happens when the conflict of interest relates to the conservatee’s substantial talents and their potential earnings? In this circumstance, a conservator has a perverse incentive to profit off of and coerce their conservatee into labor which serves to benefit the conservator—a kind of involuntary servitude that would seem to implicate the plain text of the Thirteenth Amendment of the United States Constitution.

This Note proceeds in three parts. Part I describes the history of conservatorships, why they were created, and the problematic issues that have arisen from the conservatorship system. Part II analyzes how the lack of meaningful judicial …

The Kids Aren’T Alright, Amy B. Levin

Arkansas Law Review

It is not new that students struggle in law school. Research has shown for decades that, while students generally begin law school with healthy well-being, the competitive nature of law school combined with the stress of the Bar and securing post-Bar employment causes increased anxiety, depression, isolation, and related symptoms among students, especially women and underrepresented groups. What is new is the sheer number of law students struggling with serious mental health challenges today—a number that has reached crisis proportions.

This Article is divided into four parts. In Part I, I explore the mental health landscape for high school, college, …

Arkansas Law Review - Volume 78 Issue 3, Journal Editors

Arkansas Law Review

No abstract provided.