Digital Commons Network^™

Promoting The Concept Healthy Ageing For Use In Gerontological Health And Social Care Policy And Practice, Claire Donnellan

Research outputs 2022 to 2026

Aims: The concept of healthy or successful ageing dates back to the 1960s, where its goal is more realistic in today's ageing society as a result of effective interventions to control and reduce disability and health risks. The aim of this paper is to outline the importance of defining ageing, the semantics and indicators used, and to identify common challenges for health professionals' understanding and application of a healthy ageing approach in their everyday clinical practice. Design and Methods: This discursive paper demonstrates how realistic ageing indicators are for highlighting the variation and impact of challenges associated with ageing. It …

Nation, Nature And Childhood In Five Curricula: Towards Earthly Education, Zsuzsa Millei, Katarzyna Gawlicz, Lucy Hopkins, Camilla Eline Andersen, Danielle Ekman Ladru

Research outputs 2022 to 2026

This article explores the relations between nation, nature and childhood in five early childhood education curricula in the Nordic, post-socialist and settler-colonial states with the focus on the role education plays in the face of the climate crisis. The authors identify three interconnecting themes in which nation, nature and childhood are entangled in these curricula: 1) national nature as an object of learning; 2) nature and home/birth land and Country; and 3) stewardship for national nature. Exploring these themes from the perspective of alternative pedagogies developed to address the child–nature relations during the Anthropocene, the authors argue that these notions …

Embodying Policy Work: An Exploration Of Contexts, Actions And Meanings Towards New Possibilities For Physical Education Teacher Education (Pete), Victoria Evans, David Aldous, Dawn Penney

Research outputs 2022 to 2026

This theoretical paper presents a heuristic framework that is directed towards transformative thinking and practices in Physical Education Teacher Education (PETE). The research focus and direction, embodying policy work, applies and extends Bernstein’s concepts of the pedagogic and corporeal device to offer new directions for inquiry and explore the considerations these raise for PETE professionals and their practices. The paper affirms the importance of policy work in PETE, while recognising a need for more nuanced and critical understandings of the complex interrelationships between contexts and actions, and the potential meanings generated and ascribed to different forms of policy work and …

A Figurational Analysis Of Health And/Or Physical Education Teacher Educators’ Conceptualisations Of Policy, And Their Sociogenesis, Laura Alfrey, Dylan Scanlon, David Aldous, Jenna Lorusso, Kellie Baker, Christopher Clark, Mo Jafar

Research outputs 2022 to 2026

Policy engagement is key to promoting quality physical education yet it has been identified as a ‘grand challenge’ for Health and/or Physical Education (H/PE) internationally. All H/PE professionals, including teacher educators, have a collective responsibility to engage with policy but existing research tells us little about how H/PE teacher educators (H/PETEs) understand and engage with policy. It is important to examine H/PETEs conceptualisations of policy for a few reasons, not least because teacher educators play a crucial role in supporting future generations of teachers who themselves will need to engage with policy as a core feature of their professional lives. …

Investigation Of Causal Relationships Of The Cross-Scale Wave Coupling Through Information Theoretical Approach, Elmer Rivera, J. Johnson, Simon Wing, Eun-Hwa Kim, Khan-Hyuk Kim, Katariina Nykyri

Faculty Publications

No abstract provided.

Findings And Recommendations From The State Of The Art (Sota) Conference On Nursing Research To Improve Veteran Outcomes, Amelia E Schlak, Sarah Krein, Laura A Petersen, David Atkins, Catherine Battaglia, Elizabeth Burkhart, Renee Colsch, Marguerite Daus, Heather Gilmartin, Nipa Kamdar, Melissa Knox, Ann Kutney-Lee, Christine M Olney, Kathryn Rugen, Tracy Weistreich, Sheila Cox Sullivan, On Behalf The Nursing Sota Planning Committee

Faculty, Staff and Students Publications

The Veterans Health Administration (VHA), the largest employer of nurses in the United States, has more than 120,000 nursing personnel providing care to over 9 million Veterans across diverse settings. Despite nursing's central role in delivering and sustaining care, research on strengthening the nursing workforce and optimizing nursing practice has remained underdeveloped in VHA. To address this gap, VHA's Office of Research and Development, in partnership with the Office of Nursing Services, convened a State of the Art (SOTA) conference in November 2023 focused on nursing. The Nursing SOTA brought together nurses, researchers, operational leaders, and other stakeholders to review …

Assessment Of In-Frame Indel Variants In An Unsolved Cohort Of Inherited Retinal Diseases Using Machine Learning, David E Rauch, Meng Wang, Muhammad Jafar Hussain Hafiz, Daniel C Brock, Yumei Li, Molly Marra, Mark E Pennesi, Paul Yang, Everett Lesley, Irma Lopez, Robert Koenekoop, Edward Ryan Collantes, Joanne Bolinao, Rui Chen

Faculty, Staff and Students Publications

The standard for in silico pathogenicity prediction of in-frame insertions and deletions (indels) is less established compared to other types of variations. We aimed to systematically assess the performance of in silico machine learning (ML) tools on a patient cohort with inherited retinal diseases (IRDs). The performance of four ML tools (CADD, FATHMM-indel, VEST4, and MetaRNN-indel) was compared. Among them, MetaRNN-indel showed the best overall results. MetaRNN-indel was then applied to 1013 unsolved IRD patients, identifying two likely pathogenic causal variants in two unrelated IRD patients by confirming clinical phenotypes. Hence, our findings indicate that reliable prediction of the pathogenicity …

Strategies And Challenges For The Recruitment Of Young Healthy Participants In The Dietary Approaches To Longevity And Health (Dial Health) Pilot Trial, Hannah E Cabre, Courtney M Peterson, Gareth R Dutton, Kimberly L Drews, Stephanie T Broyles, Robert Dubin, Laura Q Rogers, Catherine Champagne, Dennis T Villareal, Daniel S Hsia, Leanne M Redman, Corby K Martin

Faculty, Staff and Students Publications

Background: Understanding the impact of nutrition on human aging requires long-term trials in young, healthy, unmedicated adults. As part of the Dietary Approaches for Longevity and Health (DiAL Health) pilot project, we evaluated strategies for recruiting this population for aging-related dietary intervention studies.

Methods: We analyzed recruitment costs to enroll 70 participants (ages 25-49, BMI 22.0-29.9 kg/m2) across two DiAL Health sites and used NHANES data (2017-March 2020) to estimate the proportion of U.S. adults meeting partial trial eligibility. Additionally, a formative study surveyed 492 U.S. adults (≥18 years) to assess interest in aging-focused dietary trials.

Results: Of 2049 applicants …

Sewers To Solutions: A Guide To Wastewater Pathogen Monitoring, Justin R Clark, Anthony W Maresso

Faculty, Staff and Students Publications

Wastewater-based epidemiology (WBE) is the analysis of wastewater to detect pathogen levels or activity for public health awareness or action. Pioneered in the 1940s, WBE underwent a resurgence during the COVID-19 pandemic, providing important information about number of cases, outbreaks, and seasonal impact. With advancements in detection technologies and growing interest in environmental surveillance, WBE is poised to become a standard practice in public health monitoring. Here, we provide an overview of the current state of the art of pathogen WBE, including methods of molecular detection, analysis of wastewater data, real-world applications and programs, public health interventions, and benefits and …

Lysine Demethylase 4a Is A Centrosome-Associated Protein Required For Centrosome Integrity And Genomic Stability, Pratim Chowdhury, Xiaoli Wang, Richard I Han, Manga Motrapu, Ashley G Boice, Yuya Nakatani, Sofia Vargas-Hernandez, Julia F Love, Claude Chew, Sandra L Grimm, Dereck Mezquita, Frank M Mason, Elisabeth D Martinez, Cristian Coarfa, Cheryl L Walker, Anna-Karin Gustavsson, Ruhee Dere

Faculty, Staff and Students Publications

Centrosomes play a fundamental role in nucleating and organizing microtubules in the cell and are vital for faithful chromosome segregation and maintenance of genomic stability. Loss of structural or functional integrity of centrosomes causes genomic instability and is a driver of oncogenesis. Here we identify lysine demethylase 4A (KDM4A), an epigenetic 'eraser' of chromatin methyl marks, as a centrosome-localized protein, visualized at the nanometer-scale resolution. We additionally uncovered that KDM4A demethylase enzymatic activity is required to maintain centrosome homeostasis and integrity; a previously unknown functionality unlinked to altered expression of genes regulating centrosome number. We find that KDM4A interacts with …

Clinical Factors And Diagnoses Associated With Inappropriate Urine Culture Ordering In Primary Care, Marissa Valentine-King, Barbara W Trautner, Michael A Hansen, Roger Zoorob, Lisa C K Danek, Kenneth Muldrew, Forrest Hudson, Robert L Atmar, Larissa Grigoryan

Faculty, Staff and Students Publications

Objective: Evaluate the prevalence and risk factors for inappropriately ordered urine cultures in primary care.

Design: Cross-sectional study using chart reviews.

Setting: Two primary care, safety-net clinics in Houston, Texas.

Patients: Non-pregnant adults without a urinary catheter who had a urine culture and a primary care visit between 11/2018 and 3/2020.

Methods: We classified patients lacking physician documentation of the following symptoms as having an inappropriately ordered urine culture: dysuria, frequency, urgency, hematuria, fever, chills, costovertebral angle tenderness, nephrolithiasis, and pain (suprapubic, pelvic, or flank). We extracted patient demographics, visit-related diagnostic codes, past medical history, and urine culture results. Diagnostic …

Between Trends And Truths: Tiktok Therapy-Speak And Mental Health, Zoe Stephens

Scripps Senior Theses

The rise of therapy-speak on social media has introduced mental health terminology into everyday discourse among young adults, yet its psychological impacts remain unclear (Chevalier, 2024; Jain et al., 2025). The present study investigated the effects of TikTok videos containing therapy-speak on stigma toward mental illness, mental health awareness, and mental health literacy. Using a between-groups experimental design, 95 U.S. college students aged 18 to 24 were randomly assigned to view either therapy-speak TikTok content or neutral TikTok content. Participants subsequently completed three post-exposure measures: the Mental Health Literacy Scale (MHLS; O’Connor & Casey, 2015), a self-constructed Mental Health Awareness …

End-To-End Development And Experimental Validation Of A 1/10-Scale Autonomous Vehicle, Rikkin Pankaj Panchal

Electrical Engineering Theses

Autonomous vehicle development demands vast resources, making scaled down platforms a critical alternative for solving core algorithmic challenges. The primary contribution of this thesis is the end to end development and validation of a complete real time autonomous driving pipeline deployed on a one tenth scale vehicle. To streamline platform development, an AI assisted annotation framework automates dataset generation, significantly reducing manual labor while improving training data quality. The system perception stack features a reinforcement learning guided online multi camera calibration framework that enables adaptive surround view stitching without the need for offline recalibration. This is paired with robust lane …

Senolytic-Resistant Senescent Cells Have A Distinct Sasp Profile And Functional Impact: The Path To Developing Senosensitizers, Utkarsh Tripathi, Masayoshi Suda, Vagisha Kulshreshtha, Bryan T Piatkowski, Allyson K Palmer, Nino Giorgadze, Christina Inman, Nathan Gasek, Ming Xu, Kurt O Johnson, Tamar Pirtskhalava, Selim Chaib, Larissa P G Langhi Prata, Yi Zhu, Renuka Kandhaya-Pillai, Stefan G Tullius, Saranya P Wyles, Rambabu Majji, Hari Krishna Yalamanchili, David B Allison, Tamar Tchkonia, James L Kirkland

Faculty, Staff and Students Publications

The senescent cell (SC) fate is linked to aging, multiple disorders and diseases, and physical dysfunction. Senolytics, agents that selectively eliminate 30%-70% of SCs, act by transiently disabling the senescent cell antiapoptotic pathways (SCAPs), which defend those SCs that are proapoptotic and pro-inflammatory from their own senescence-associated secretory phenotype (SASP). Consistent with this, a JAK/STAT inhibitor, Ruxolitinib, which attenuates the pro-inflammatory SASP of senescent human preadipocytes, caused them to become "senolytic-resistant". Administering senolytics to obese mice selectively decreased the abundance of the subset of SCs that is pro-inflammatory. In cell cultures, the 30%-70% of human senescent preadipocytes or human umbilical …

Corals, Creation, And Conservation: Evaluating Human-Marine Relations Through Coral Reef Biology And Artistic Practice, Emma Gray Garman

Scripps Senior Theses

This thesis investigates the relationship between humans and marine ecosystems through two complementary lenses: scientific research and artistic practice. The biology chapter proposes a five-year coral reef monitoring study across four Queensland, Australia islands — two heavily visited and inhabited (Fitzroy and Green Islands) and two minimally visited and uninhabited (High and Woody Islands) — to assess whether human activity correlates with bleaching severity over time. Grounded in preliminary survey data from Green Island in 2024, which revealed approximately 54% of coral bleached or dead, the study hypothesizes that reefs adjacent to inhabited islands will exhibit greater bleaching severity, consistent …

Spectral Decimation On The Schreier Graphs Of The Basilica Group: A Thesis In Fractal Analysis, Anne D. Bannon

Scripps Senior Theses

This thesis is intended to provide a comprehensive overview of the literature required to fully understand research conducted during the University of Connecticut's Fractals & Stochastics REU in the summer of 2025. The literature review includes a description of Robert Strichartz's seminal work pertaining to the Laplacian spectrum of the Sierpiński Gasket, which provides a framework for how we approach studying the spectrum of the basilica Julia set. Defining the basilica Julia set and the closely-related Basilica group involves graph theory, automata theory, iterated monodromy group theory, and amenable group theory. Further time is dedicated to defining the graph Laplacian …

Appalachia In Presidential Campaign Rhetoric Since 1964, Meredith Morello

Scripps Senior Theses

This thesis examines how presidential candidates have invoked Appalachia in campaign rhetoric from Lyndon B. Johnson's 1964 election through 2024, arguing the region functions not as a geographic reference but as a strategically deployable political symbol. Through mixed-methods analysis of 83 campaign-period sources archived in the American Presidency Project, a structured thematic coding schema traces how candidates frame the region across six decades using two analytically distinct modes: objective-economic and moralized-culture framing.

Five major structural patterns emerge: Johnson's institutionalization of the region as bounded domestic poverty; strategic silence during national instability; reframings enabling rhetorical reentry; symbolic portability across ideological projects; …

Making Faces, Elinor Attisani

Scripps Senior Theses

Making Faces critiques the naturalization of gender norms and asserts that all gender expression is learned and imitative. With respect to my work, “naturalization” refers to the attribution of patterns of behavior to an unbreakable essence at the core of a person; the distinct qualities that place masculinity and femininity in opposition are often attributed to natural characteristics of the male and female sexes. Judith Butler famously contradicts this myth of gender expression as the externalization of an underlying core identity in their book, Gender Trouble, where they argue that the repeated imitation of a nonexistent ideal is constitutive of …

Modeling French Language Preservation: An Optimal Control Problem, Charlotte Blasi

Scripps Senior Theses

The French language is one of the most globally spoken languages, with over 300 million speakers and designated the official language of 29 nations. French continues to prosper as a result of its titular nations' imperialist history that emphasized linguistic diffusion as well as the support of international organizations dedicated to promoting both the language and the culture of French-speaking nations. In this thesis, we explore the nuanced history of French-speaking countries and one institution dedicated  to promoting the French language, the OIF. We further examine the media mechanism of the OIF and construct a system of Ordinary Differential Equations …

From South Korea To South Central: The 1992 Los Angeles Uprising And The "Rooftop Korean", Mina Althea Lamson Jung

Scripps Senior Theses

This thesis examines the historical formation of the "rooftop Korean," the racial figure of the armed Korean American shopkeeper that emerged during the 1992 Los Angeles Uprising and has since been mobilized repeatedly in service of anti-Black counterinsurgency. Drawing on the framework of racial capitalism, this thesis argues that the rooftop Korean was not a spontaneous product of the Korean-Black conflict in South Central Los Angeles but the culmination of decades of U.S.-Korea relations, South Korean militarization, and the racial geography of capitalist development on both sides of the Pacific.

Tracing a transnational arc from the Korean War through the …

The Split Child: Fragmented Temporalities And Selves In Post-Francoist Horror Cinema, Harper A. Denniston

Scripps Senior Theses

This thesis interrogates the prolific figure of the spectral child in post-dictatorial horror cinema in Spain. During the renaissance wave of the horror boom (a period between the late 1990s and early 2000s that experienced a surge in horror films), narratives of haunting often presented the ghost in child form, blending childhood and horror. This thesis examines the spectral child as depicted in the seminal horror films The Devil’s Backbone (2001) and The Orphanage (2007). First, I establish the historical context behind these films, exploring the traumatic history of children during the Spanish Civil War and Franco dictatorship, Spain’s cultural …

Shrines On Asphalt Shoulders: Documenting Roadside Memorials In Western U.S. Roadscapes, Isabella R. Sullivan

Scripps Senior Theses

This thesis analyses the practice of documenting and uploading roadside memorials in the Western United States as a socially transformative process facilitated between two distinct kinds of noticing. Drawing on (auto)ethnographies of roadside memorial sites in Colorado and California, interviews with photographers and cartographers working primarily in the American Southwest, and Google Street View media, this research examines how recognition of the social negotiations involving memory and mortality that are already present in the physical shrines evolves when documenters capture and transpose them online. First, these documenters have developed the “eyes to see” roadside memorials for various significant reasons in …

The Politics Of Fatness And The Demand For Our Collective Joy, Sky Caldwell

Scripps Senior Theses

The Politics of Fatness and the Demand for Our Collective Joy aims to assess the political-economic reasonings behind the return of overt anti-fatness and its coincidence with the re-normalization of the far right. My research looks at the sudden mass marketing of GLP-1 drugs and the use of the body as a spatial fix during recession-era economic conditions. First, this interdisciplinary project asks why the body positivity movement has not been successful in the greater fight against anti-fatness. Then, through archival research, discourse analysis, ethnographic interviews, and photography, my project explores various case studies of successful spaces and collectives working …

The Purimspiel: A Compilation Play, Jordan G. Becknell

Scripps Senior Theses

This thesis covers the process of researching, writing, and developing The Purimspiel: A Compilation Play. This playwrighting project explores the dissonance between the cultural memory of the Jewish holiday Purim and the holiday’s long-documented association with Jewish violence and vengeance as it connects to the modern questions of Jewish identity in the wake of the ongoing genocide in Gaza.

The Demand For Attention: Notification Technology And The Restructuring Of Communication, Sabrina Feld

Scripps Senior Theses

This thesis argues that notifications are not merely features of digital devices but infrastructural forces that quietly reorganize the conditions under which communication is perceived, enacted, and understood. Drawing on Science, Technology, and Society (STS) frameworks, specifically Actor-Network Theory and Langdon Winner's concept of Forms of Life, the first chapter traces how notifications produce a Form of Life organized around continuous responsiveness, in which incoming information appears as a pending demand, silence carries new moral weight, and the capacity for self-determined availability is structurally foreclosed. Understood this way, notifications become a case study for a broader pattern in which technological …

Viral Misunderstandings: Reddit Posts And The Covid-19 Infodemic, Julia C. Knutson

Scripps Senior Theses

Information epidemics or “infodemics” became the center of misinformation conversations, due to a global increase in information spread surrounding the COVID-19 pandemic. While many academic scholars and institutions, such as the World Health Organization (WHO) attribute the cause of infodemics to anti-science attitudes and the public’s lack of scientific literacy, scholars in Science, Technology, and Society argue that analyzing misinformation within these isolated bounds limits our understanding of its underlying social and historical contexts. Using the COVID-19 pandemic as a case study for misinformation analysis reveals a gap in our current understanding of how people who resonate with or spread …

I Am Hookman: A Reflection, Fiona E. Larsen-Teskey

Scripps Senior Theses

I am Hookman is a reflection paper on my process, experience, and growth performing in the play, Hookman, as my senior thesis.

(Dis)Orientations: Finding Rhythm Within Queer Nightlife In Los Angeles, Frances Bright Currie

Scripps Senior Theses

This thesis examines how queer individuals in Los Angeles perceive, inhabit, and reshape their experiences in queer cultural spaces. Through this project, I trace the evolution of queer nightlife in Los Angeles (from early gay counterspaces, through the collectivist politics of the Queer Nation, to post-gay assimilation and contemporary “inclusive” queer nightlife) in order to examine how queer space has been shaped and reshaped by a recurring tension between the utopian promise of universality and inclusion and the material realities of exclusion. Drawing on ethnographic fieldwork, queer theory, and approaches to memory and the archive, I argue that queer nightlife …

Facebooking Under Crisis: A Comparative Study Of Online French And American Mutual Aid Organizing During The Covid-19 Pandemic, Clare Reimers-Hejnal

Scripps Senior Theses

This thesis studies the political discussions, practices, and projects that emerged through mutual aid Facebook groups based in France and the United States during the COVID-19 pandemic. Of particular interest is how these online spaces and the Facebook users that comprised them understood their mutual aid organizing in relationship to specific themes, including but not limited to: the COVID-19 pandemic as a "crisis", the role of government presence or absence in the wellbeing of the public, and the concept of collective yet differentiated struggle. Chapter 1 looks at four Facebook pages based in the greater Paris area: Entraide Danube, Clichy …

Still Life As A Photographer: Visual And Mnemonic References To Photography In Yasuo Kuniyoshi’S 1944 Broken Objects And Room 110, Tara A. Attanasio

Scripps Senior Theses

This thesis examines Yasuo Kuniyoshi (1889-1953) and his still life paintings titled Broken Objects and Room 110 as modes of implicit portraiture, self-declaration, and self-reclamation. Following the attack on Pearl Harbor on December 7th, 1941, government authorities deemed Kuniyoshi an “enemy alien” and confiscated his photographic equipment. Painted two years following his camera’s confiscation, Broken Objects and Room 110 contain references that recall Kuniyoshi’s prewar photographic practice and visualize his response to the loss of his camera. I foreground my analysis with Kuniyoshi’s Self-Portrait as a Photographer from 1924 and his photography from the 1930s to detail his metacritical relationship …