Digital Commons Network^™

Altered Bile Acid Transport In Liver Disease, Sarah Cayton, Lindsay C. Czuba

Pharmaceutical Sciences Faculty Publications

Background/Objectives: Bile acids, synthesized from cholesterol in the liver, are amphipathic molecules that play an integral role in lipid digestion and absorption, while also serving as systemic endocrine hormones. They continuously undergo enterohepatic circulation, where they interact with various transporter proteins. Dysregulated bile acid transport is associated with the pathogenesis of liver disease. This review summarizes the key findings relating to bile acid transport expression and activity in the pathogenesis of liver disease.

Methods: A review of the literature was performed using PubMed and relevant terms including, but not limited to, “bile acid transporters”, “liver disease”, and “bile acid uptake …

Beyond Fixed Thresholds: Per-Label Calibration For Fine-Grained Emotion Detection On The Goemotions Dataset, Sai Puneet Naga Venkata Subramanyam Patchipulusu

Selected Full-Text Master Theses 2021-

This study investigates the effectiveness of five community fine-tuned transformer models for fine-grained emotion detection on the GoEmotions dataset: SamLowe/roberta- base-go_emotions (RoBERTa-base), cirimus/modernbert-base-go-emotions (ModernBERT), mrm8488/deberta-v3-base-goemotions (DeBERTa-v3-base), bhadresh-savani/bert-base-go- emotion (BERT-base-cased),and tasinhoque/distilbert-go-emotions (DistilBERT) . While the original GoEmotions research by Demszky et al. (2020) established a BERT-base baseline with a macro-F1 of 0.46, this thesis extends that work through independent empirical evaluation of five derivative models, systematic per-label threshold optimization, and comparative analysis of architectural trade-offs across the full transformer model family. Using the GoEmotions simplified test split (5,427 examples across 28 categories), all five models were evaluated at a fixed 0.5 …

Solving The Middle School Math Problem To Increase Achievement, Andre Goodlow

Educational Leadership Professional Doctorate Dissertations

This study used improvement science to address persistent and disproportionate low mathematics achievement among middle school students, particularly Black/African American and Hispanic students, in an urban school district in the Pacific Northwest. Local data indicated significant deficiencies in math proficiency, with the target district exhibiting achievement disparities exceeding state averages. The project investigated root causes of low math achievement, prioritizing the enhancement of foundational math skills and the implementation of evidence-based interventions. The improvement theory centered on deploying an evidence-based core math curriculum and intervention program for incoming middle school students, tested through cycles during a four-week summer school program. …

Pláticas Of Latinas In Educational Leadership: Stories Of Identity, Resilience, And Transformation, Vanessa Davalos

Educational Leadership Professional Doctorate Dissertations

Despite federal and state equity laws that prohibit discrimination based on sex and national origin, women remain significantly underrepresented in K–12 educational leadership, with Latina leaders experiencing even greater disparities. While the number of Hispanic students in public schools continues to grow, the representation of Latina leaders has not kept pace, creating a critical gap between those leading schools and the communities they serve.

The purpose of this qualitative phenomenological study is to provide insight into the lived experiences of Latina educational leaders in order to deepen understanding of how identity, role, and leadership intersect (Hernandez & Murakami, 2016). Centering …

Establishing A Public Health Surveillance System For The Opioid Crisis: The Experience Of The Healing Communities Study, Bridget Freisthler, Daniel J. Feaster, Charles Knott, Marc Larochelle, John Mccarthy, Svetla Slavova, Sharon L. Walsh, Jennifer Villani

Biostatistics Faculty Publications

Introduction: Efforts to reduce opioid overdose deaths in the United States have been stymied by the lack of timely and standardized population-level data for local, state, and national levels. The U.S. has a strong national need for linking opioid and other drug overdose surveillance data to service utilization data for overdose prevention and treatment to inform resource allocation and response planning.

Methods: We provide insight on the challenges of identifying, obtaining, and harmonizing administrative outcome data across four states using the collective experience from the HEALing Communities Study to test a community-engaged, data-driven, population-level intervention to reduce opioid overdose deaths. …

Pediatric Clinical Reasoning Labs’ Impact On Student Self-Efficacy In Pediatric Physical Therapy Education, Bethany Early

Dissertations

All graduates of entry-level Doctor of Physical Therapy (DPT) programs must be competent to work with patients across the lifespan and high levels of perceived self-efficacy (SE) may be a predictor of future success. Experiential learning is an effective teaching and learning strategy used within Pediatric PT education (PedPTE). This study examined the extent to which pediatric clinical reasoning labs impact student SE within PedPTE, and to what extent does previous experience or interest in pediatrics have on perceived SE.

The methodology was a sequential explanatory mixed methods research design. Quantitative data collection included 27 second year DPT students, utilizing …

From Voice To Noise: Accented Speech, Constructed Languages, And Subtitling Practices As Markers Of Difference, Alice Alonso Limongi

Course Work

This monograph explores three main strategies of vocal exotification in Anglophone film: representations of accented speech, inclusion of constructed languages, and non-subtitling of snippets of other languages. Using Stuart Hall’s encoding/decoding framework, I approach these practices as rhetorical devices that both construct and are constructed by the complexity of our social landscapes. Portrayals of accented speech, constructed languages, and subtitling practices form a gradient of abstraction, where the denotative meaning of words gradually loses importance to the sonic characteristics of the voice. Combining broader cultural scholarship from Edward Said, sound studies writings on power and language from Nina Sun Eidsheim …

Enabling Communication Resiliency In The Connected Car Environment, Antonio Guerrero-Ibáñez, Juan Contreras-Castillo, Sherali Zeadally, Een-Kee Hong

Information Science Faculty Publications

Connectivity has become integral to various application domains, with the automotive sector as a prime example. Advances in electronics, computing, and telecommunications have driven the evolution of the connected car ecosystem, transforming it into a data-rich environment that enhances road safety, efficiency, and overall mobility. However, the success of this ecosystem depends on seamless, reliable, and resilient communications. We identify key challenges that may affect communications in the connected car environment and discuss solutions that enhance resiliency and robustness. Finally, we propose a multi-layered network architecture that will enhance communication resilience in the connected car ecosystem.

Family Functioning And Stress In Arab American Young Adults, Sahar Kaouk

Selected Full-Text Dissertations 2020-

Family functioning plays a central role in the lives of Arab American young adults, yet little research has examined how family dynamics relate to stress in this population. Guided by Bowen’s (1978) Family Systems Theory, this study investigated the relationship between family functioning and perceived stress, as well as the roles of Differentiation of Self (DoS), Reflective Coping, and collectivistic orientation. Participants included 225 young adults ages 18 to 25 who self-identified as Arab American. Data were collected using self-report measures, and structural equation modeling was used to test the hypothesized model. Results indicated that family functioning was indirectly related …

Democracy And Development In American History, Michael T. Rock

Economics Faculty Research and Scholarship

No abstract provided.

Songs Of The Sea: Reading The Archival Waters Of Afrodiasporic Literary Worlds, Charlee Thacker

Senior Honors and Award-Winning Theses

No abstract provided.

An Intersectional Investigation Of Gendered Racial Microaggressions And Asian American Women’S Body Appreciation, Liujun Chen, Xiaoyin Liu, Thomas P. Le, Lydia H.R. Ahn

Psychology Faculty Research and Scholarship

While some research has explored the cultural correlates of negative body image among Asian American women, fewer studies have addressed what may contribute to body appreciation among Asian American women. We recruited a sample of 234 Asian American women via Prolific, who completed an online survey. Specifically, the present study examined (1) whether gendered racial microaggressions were associated with body appreciation among Asian American women, (2) whether resistance and empowerment against racism moderated this association, and (3) whether three subscales of internalized racism—self-negativity, weakness stereotypes, and appearance bias—mediated this association. A regression analysis showed a negative association between gendered racial …

The Impact Of Intimate Partner Violence On Victims’ Mental, Physical, And Economic Well-Being: A Comprehensive Literature Review (2012–2022), Kerry Lee, Jennifer L. Mezzapelle, Lyric N. Russo, Emily M. Douglas, Denise A. Hines

Graduate School of Social Work and Social Research Faculty Research and Scholarship

Intimate partner violence (IPV) remains a significant global public health concern, drawing increasing attention due to its profound impact on victims. A systematic review by Lawrence et al. (2012) demonstrated that IPV victims of physical and psychological abuse experience higher rates of physical injuries, poorer health outcomes, poorer physical functioning, and increased psychological symptoms compared to non-victimized individuals. Building on this work, we conducted a systematic review of 159 quantitative studies published between 2012 and 2022.

Across the included studies, more than half had samples ranging between 100-500 (52.8%, n=84) in size, were cross-sectional (84.9%; n=135), and utilized …

Development Of Highly Reactive Sulfone Iminium Fluoride Reagents And Their Application In Fluorine Methodologies, James Vogel

Bryn Mawr College Dissertations and Theses

Organofluorines are important molecules that have found great use in the pharmaceutical industry. Deoxyfluorination is an appealing methodology available to synthetic chemists for forming carbon-fluorine bonds. In the first part of this work, we report the synthesis of sulfone iminium fluorides (SIFs), a new and highly reactive sulfur (VI) fluoride reagent class. A small library of these compounds was synthesized in five simple, modular steps from cheap starting materials. The SIF reagents successfully convert alcohols and carboxylic acids into their corresponding fluorinated moieties in high yields at room temperature with unprecedented reaction speed, requiring just 60 seconds. Furthermore, the SIF …