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Andres Macias-Chamaidan V. Attorney General United States Of America

2026 Decisions

Agency

Impact Of Apitegromab On Motor Function In Spinal Muscular Atrophy, Jordyn Linfield, Ashley Jacob, Haylee Whyde, Owen Fox, Kaitlyn Bowden, Connor Dains, Brenna Hissong, Manoranjan D'Souza

Pharmacy and Wellness Review

Spinal muscular atrophy (SMA) is an inherited neuromuscular disorder characterized by the progressive loss of alpha motor neurons in the anterior horn of the spinal cord, leading to muscle weakness, atrophy, and impaired motor function.¹ SMA remains an extensive and difficult-to-treat condition, with only three disease-modifying therapies currently available to patients. A new investigational agent with a unique mechanism of action, apitegromab (SRK-015), has shown promising results in recent clinical trials. The safety and efficacy of apitegromab in patients with SMA have been explored in several clinical trials, with the TOPAZ and SAPPHIRE studies being the most notable. This …

Intouch Week Of January 12, 2026, New York Medical College

InTouch

• Department of Cell and Molecular Physiology Unites Three Disciplines
• Paul Arnaboldi, Ph.D., Receives More Than $500,000 NIH Grant to Support Respiratory Vaccine Development
• Action speaks louder than words in dealing with antisemitism and violence
• Celebrate the Publication of the 8th Edition Principles and Practice of Radiation Oncology
• Gabriel Project Mumbai, Welcomes Second Cohort of TCDM Students and Faculty
• Love at NYMC
• Student Spotlight: A Full-Circle Journey

Reformulation Of The Protein Databank For Real-Time Search Of Geometrical Attributes Of Protein Structures, Musa Azeem, Christopher Lee, Aaron Hein, Christopher Ott, Homayoun Valafar

Faculty Publications

Introduction:

In this study, we introduce the design and implementation of PDBMine, a large-scale, queryable platform for mining sequence-structure statistics from the Protein Data Bank (PDB). PDBMine enables rapid analysis of local conformational trends across proteins by extracting dihedral angles and sequence patterns at scale. In addition to the design and implementation of PDBMine, we also present results validating its ability to return structurally meaningful information.

Methods:

We first assess the accuracy of its dihedral angle distributions by comparing them to established Ramachandran space and verifying expected behaviors of residues such as glycine and proline. We then use PDBMine to …

Optimal Quantization Of Finite Uniform Data On The Sphere, Mrinal Kanti Roychowdhury

School of Mathematical & Statistical Sciences Faculty Publications

This paper develops a systematic and geometric theory of optimal quantization on the unit sphere 𝕊2, focusing on finite uniform probability distributions supported on the spherical surface—rather than on lower-dimensional geodesic subsets such as circles or arcs. We first establish the existence of optimal sets of n-means and characterize them through centroidal spherical Voronoi tessellations. Three fundamental structural results are obtained. First, a cluster-purity theorem shows that when the support consists of well-separated components, each optimal Voronoi region remains confined to a single component. Second, a ring allocation (discrete water-filling) theorem provides an explicit rule describing how optimal representatives are …

The Regulation Of Technological Innovation In Financial Services: A Comparative Approach With Respect To Digital Assets And Artificial Intelligence, Howell E. Jackson, Katja Langenbucher

Law and Contemporary Problems

No abstract provided.

The Divergence Of Mandatory Climate Disclosure In The United States And European Union, Alessio M. Pacces, David Zaring

Law and Contemporary Problems

No abstract provided.

Alcohol And The Endocrine System: A Critical Review Of Disruptions, Potential Mechanisms, And Health Implications, Patricia E. Molina, Liz Simon

School of Graduate Studies Faculty Publications

The endocrine system coordinates and integrates cellular activity throughout the body by regulating cellular and organ function and maintaining homeostasis. Homeostasis, the dynamic maintenance of internal balance despite changing external or internal conditions, is essential for proper cellular function. The endocrine system achieves this through a complex regulatory network of hormone-mediated signaling among multiple endocrine organs, relying on precisely regulated synthesis and release of hormones and specific hormone-receptor interactions. Endocrine-mediated actions coordinate critical physiological processes, including growth, metabolism, reproduction, stress adaptation, and circadian rhythms throughout the lifespan. Endocrine glands—such as the hypothalamus, pituitary, thyroid, parathyroid glands, pancreas, adrenal glands, and …

Association Between Lifestyle And Dietary Habits With C-Reactive Protein And Glucose: A Cross-Sectional Study, Mohammad Ariful Islam, Reaz Morshed, Shamim Alam, Jakir Hossain, Md Shahedul Islam

School of Integrative Biological & Chemical Sciences Faculty Publications

Background and Aims: Lifestyle and diet influence chronic disease risk through their impact on systemic inflammation. This research evaluated the association among dietary habits, physical activity, and inflammatory biomarkers, specifically glucose and C-reactive protein (CRP). Methods: This cross-sectional study examined lifestyle, sociodemographic, and nutritional indicators using a structured questionnaire, which was adapted from the WHO STEPwise guideline. A total of 200 participants were included based on their attendance for CRP and glucose assays at two health centers between May and September 2023 in Bangladesh. Results: Among participants with high fiber intake (> 20 g/day), 22% had normal blood glucose levels …

Adaptable Psychopathic Traits: Military And Para-Military Organizations, Mariana Ramirez

Student Theses

Although culturally distinct, both military and law enforcement careers demand individuals to operate effectively in high-risk environments; a characteristic shaped through processes of military and para-military occupational socialization, reinforced by an adaptable personality. Understanding the distinctions between military and law enforcement cultures provides a foundation for examining individual-level factors such as personality, behavior, and mental health. Recent research (e.g. Anestis et al., 2019; Batastini et al., 2023; Falkenbach et al., 2017; Falkenbach et al., 2018; McKinley & Verona, 2023; Patton et al., 2018; Preston et al., 2020; Roșca et al., 2021) has increasingly applied a psychopathic framework to study these …

Self-Efficacy Change Among Diverse Family Caregivers In Dementia Care, Deborah M Oyeyemi, Erich J Greene, Yunshan Xu, David R Lee, Rafael Samper-Ternent, Maya L Lichtenstein, Alan Stevens, Jeff D Williamson, Arun S Karlamangla, Debra Saliba, David B Reuben

Faculty, Staff and Student Publications

Objectives: To determine whether changes in caregiver self-efficacy (beliefs about one's ability to manage dementia-related problems and access help) differed by caregiver race and ethnicity across all participants enrolled in a large pragmatic trial of comprehensive dementia care.

Methods: In the Dementia Care Study (D-CARE), community-dwelling older adults with dementia and their unpaid family caregivers were randomized to receive usual care, community-based, or health system-based comprehensive dementia care. Caregiver self-efficacy was assessed at baseline, 6 months, and 18 months using a 4-item scale (range 4-20, higher scores indicate greater self-efficacy). Among all caregivers, we compared least squares means for overall …

Kindergarten Teachers’ Experiences And Training With Critical Reflection To Support Adaptive Teaching, Tessa Cushman

Walden Dissertations and Doctoral Studies

The problem that was addressed in this study is that kindergarten teachers often lack training in critical reflection as part of their adaptive teaching practice. Despite much research on critical reflection, there was a lack of knowledge regarding training kindergarten teachers receive on critical reflection and how they use it to adapt their teaching. The purpose of this study was to explore the experiences of kindergarten teachers regarding the training they received on critical reflection and the support they felt they needed to implement critical reflection for an adaptive teaching practice. Schön’s reflective practice theory was the conceptual framework for …

Play-Based Curriculum, Marina E. Prawdzik

Masters Projects

This project addresses the drastic decline of play and play-based learning in public education early childhood settings. Kindergarten classrooms have shifted their focus more to academics in the form of lecture based learning and lessons, rather than play based learning techniques. Because of this, children are lacking in cognitive development, physical development and social and emotional development and growth. This project includes research from within the state of Michigan, research within the United States as a whole, and research about play based learning from other countries such as Nigeria, Mexico, South Africa, Kenya, Finland, and Germany.

Report On A Self-Directed Pilot Study (For Students), Yoshihiko Ariizumi

Spiritual Proficiency

Level Up Your Life: The Science of Spiritual Growth

Ever feel like you're stuck in "mental noise" or struggling to stay focused? This study explores how a simple 4-week routine can literally "accelerate" your brain and emotional resilience. By using checklists and specific mental "switches," I found that we can turn daily frustrations into moments of gratitude and even boost our ability to learn complex subjects. This isn't just about faith; it's about a practical "system" to help you stay calm, sharp, and connected to your higher purpose in a busy world.

Report On A Self-Directed Pilot Study (For Researchers), Yoshihiko Ariizumi

Spiritual Proficiency

Strategic Self-Regulation for Spiritual and Cognitive Enhancement

This pilot study investigates the impact of structured spiritual interventions on cognitive processing and emotional regulation. By integrating meta-cognitive tools—such as narrative accountability, systematic scripture application, and "mental toggles" via hymns—the research demonstrates a significant acceleration in learning efficiency and a reduction in emotional recovery time. The findings suggest that spiritual experiences are not merely random occurrences but "probability-controllable phenomena" that can be systematically cultivated through intentional environmental settings and habitual reflection.

Lanthorn, Vol. 60, No. 09, January 12, 2026, Grand Valley State University

Volume 60, August 4, 2025 – April 20, 2026

Lanthorn is Grand Valley State's student newspaper, published from 1968 to the present.

Employing Ai Tools To Predict Features For Dental Care Use In The United States During The Global Respiratory Illness Outbreak, Preeti Pushpalata Zanwar, Hamid-Reza Kodan-Ghadr, Vijayakumar Thirumalai, Suad Ghaddar, Shuo Jim Huang, Beth Harkness, Eben Rey, Romanch Shah, Sairaja Reddy Kurelli, Jay S. Patel

Health & Biomedical Sciences Faculty Publications

No abstract provided.

Spatial Omics At The Forefront: Emerging Technologies, Analytical Innovations, And Clinical Applications, Yunhe Liu, Yibo Dai, Linghua Wang

Faculty, Staff and Student Publications

Spatial omics transforms our understanding of cancer by revealing how tumor cells and the microenvironment are organized, interact, and evolve within tissues. Here, we synthesize advances in spatial technologies that map tumor ecosystems with unprecedented fidelity. We highlighted analytical breakthroughs-including multimodal integration and emerging spatial foundation models-that resolve functional niches and spatial communities, converting spatial patterns into mechanistic insights. We summarize how spatially organized features, from immune hubs to microbiota and neural interfaces, shape tumor evolution and clinical outcomes. We then outline how spatial approaches illuminate precancer biology, metastatic adaptation, and therapy response. Bridging discovery and translation, we provide a …

Contribution To The Chemotherapy Of Human Trypanosomiasis: Design, Synthesis, And Biological Evaluation Of Dimeric 2-Nitroimidazoles Against Trypanosoma Cruzi Amastigotes And Bloodstream Trypanosoma Brucei, Afonso Santine M.M. Velez, Otavio Augusto Chaves, Carlos Serpa, Fatma M. Salem, Bibo Li Ph.D., Bin Su Ph.D., Celio Geraldo Freire-De-Lima, Debra Decote-Ricardo, Marco Edilson Freire De Lima

Biological, Geological, and Environmental Faculty Publications

Effective and safe treatments for neglected tropical diseases caused by parasites, such as Chagas disease and sleeping sickness, remain lacking, posing a significant challenge for researchers worldwide. The rational design of dimeric compounds inspired solely by the pharmacophoric core of benznidazole (2-nitroimidazole) has proven to be a promising strategy for antiparasitic development. Thus, in the present work, it was increased the linker between the active units (2-nitroimidazole) to improve the interaction with TcNTR, facilitating the bioactivation of the longest dimers. Biological assays confirmed this, demonstrating that all compounds were active against replicative intracellular amastigotes of Trypanosoma cruzi (Tulahuen C2C4-LacZ). Notably, …

Insight Into The Decalcification Mechanism Of Calcium Silicate Hydrate Under A Water–Heat–Salt Environment, Wei Zhang, Boya Zhang, Jia Sun, Juntao Dang, Xiangke Guo, Keliang Li, Bo Tao Huang, Biqin Dong, Hongyan Ma, Dongshuai Hou

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

Understanding the decalcification mechanism of calcium silicate hydrate (C–S–H) under marine environments is crucial for concrete durability. In this study, the decalcification behavior of C–S–H under a water–heat–salt environment was systematically investigated through immersion experiments and reactive molecular dynamics simulations. Experimental results showed that elevated temperature and NaCl solution significantly accelerated Ca leaching and reduced the Ca/Si ratio of C–S–H. Simulation results further revealed that both high temperature and NaCl reduce the dissolution free energy of Ca, making its release more thermodynamically and kinetically favorable. Local structure analysis indicated that Cl^– disrupts Ca–Os (O atoms in silicate tetrahedra) connection …

Nursing Leadership Strategies In A New Paradigm For Nursing's Economic Value, Marianne Weiss, Sharon H. Pappas, Maureen Chadwick, Beth Oliver, Olga Yakusheva

Individual Open Access Articles

Nursing leaders increasingly recognize that, in today's complex healthcare environment, nurses are a crucial revenue-generating human capital asset, not just a costly labor input. In this article, the authors discuss nursing leadership strategies to amplify nursing's economic value to healthcare organizations.

Wild@Fire2025: Overview Of Word-Level Code-Mixed Language Identification In Dravidian Languages, Ameeta Agrawal, Asha Hegde, Sharal Coelho, Sabur Butt, Fazlourrahman Balouchzahi, Sudha V, Shashirekha Hosahalli Lakshmaiah

Computer Science Faculty Publications and Presentations

Code-mixing is considered as a linguistic phenomenon that combines several languages into one text. It has now become very common in multilingual societies, especially in digital communication. Word-Level Identification of Languages in Dravidian Languages (WILD) - a Code-mixed Language Identification (CoLI) in Dravidian languages shared task, organized as a part of Forum for Information Retrieval and Evaluation (FIRE) 2025, put forward these challenges to the researchers by asking them to develop models capable of classifying words in code-mixed texts involving Dravidian languages - Tamil, Telugu, Malayalam, Kannada, and Tulu, which are interwoven with English. It poses significant challenges due to …

“She Was My Egg Donor, Not My Mom”: Using Attribution Theory To Understand How Adult Daughters Manage Their Low-Quality Daughter-Mother Relationship, Denise Alonso-Pecora, Crystal Nguyen, Jennifer L. Bevan, Michelle Miller-Day, Allison Alford

Communication Faculty Articles and Research

This study employs attribution theory to examine how adult daughters from low-income backgrounds perceive and manage low-quality daughter-mother relationships. Using in-depth interviews and flexible coding, we analyzed how daughters (n = 42) attribute locus, responsibility, specificity, and stability. Daughters often located control internally within their mothers, citing enduring traits as sources of conflict while noting external influences such as trauma or substance abuse. Responsibility was frequently self-assumed despite blaming mothers, positioning attribution as a means of asserting agency. Many saw their relationships as uniquely difficult and consistent, reinforcing perceptions of stability and specificity. Our study extends attribution theory to …

Dynamic Fib-4 Score Changes And Hcc Risk In Patients With Masld And Elevated Liver Enzymes: A Nationwide Cohort Study, Yee Hui Yeo, Hsiu J Ho, Tsai-Wei Huang, Teng-Yu Lee, Ju Dong Yang, George Cholankeril, Chien-Jen Chen, Hawi-I Yang, Chuen-Fei Chen, Hung-Chuen Chang, Chun-Ying Wu

Faculty, Staff and Students Publications

Introduction: Hepatocellular carcinoma (HCC) can develop in individuals with metabolic dysfunction-associated steatotic liver disease (MASLD) without cirrhosis, especially in those with elevated liver enzymes. However, there is currently no low-cost, scalable screening tool for this population. To address this need, we investigated the association between serial changes in FIB-4 (fibrosis-4) scores over a 3-year period and the risk of developing HCC in a large, diverse cohort of patients with MASLD without cirrhosis.

Methods: This study utilized a nationwide cohort from the National Health Insurance Research Database (NHIRD), including 810,698 patients with MASLD who had demographic and laboratory data at baseline …

Tumor-Infiltrating Bacteria Disrupt Cancer Epithelial Cell Interactions And Induce Cell-Cycle Arrest, Jorge Luis Galeano Niño, Falk Ponath, Victor A Ajisafe, Clara R Becker, Andrew G Kempchinsky, Martha A Zepeda-Rivera, Javier A Gomez, Hanrui Wu, Jessica G Terrazas, Heather Bouzek, Elizabeth Cromwell, Pritha Chanana, Matthew Wong, Ashish Damania, Michael G White, Y Nancy You, Scott Kopetz, Nadim J Ajami, Jennifer A Wargo, Christopher D Johnston, Susan Bullman

Faculty, Staff and Student Publications

Tumor-infiltrating bacteria are increasingly recognized as modulators of cancer progression and therapy resistance. We describe a mechanism by which extracellular intratumoral bacteria, including Fusobacterium, modulate cancer epithelial cell behavior. Spatial imaging and single-cell spatial transcriptomics show that these bacteria predominantly localize extracellularly within tumor microniches of colorectal and oral cancers, characterized by reduced cell density, transcriptional activity, and proliferation. In vitro, Fusobacterium nucleatum disrupts epithelial contacts, inducing G0-G1 arrest and transcriptional quiescence. This state confers 5-fluorouracil resistance and remodels the tumor microenvironment. Findings were validated by live-cell imaging, spatial profiling, mouse models, and a 52-patient colorectal cancer cohort. Transcriptomics reveals …

Social Prescribing Within Five European Countries: A Protocol Of A Cross-Country Qualitative Analysis, Stephanie Tierney, Debra Westlake, Farhad Rezvani, Daniela Rojatz, Juliane Köberlein-Neu, Trutz Bommhardt, Sónia Dias, Maria João Marques, Donata Kurpas, Hendrik Napierala, Wolfram Herrmann, K Husk

Peninsula Medical School

Introduction Social prescribing is an approach to addressing non-medical issues affecting people’s health and well-being (eg, loneliness, housing or financial problems). It has gained international traction over recent years as complementary to medical care. A larger research project, comparing social prescribing across European countries, is considering how to tailor provision for the following groups: (a) LGBTIQ+persons, (b) refugees and first-generation immigrants and (c) older adults living alone. As part of this research, a qualitative study will address the question: What are the enabling and limiting factors associated with implementing social prescribing, across different European countries, from the perspective of key …

High-Sensitivity Cardiac Troponin I And Frailty: Associations With The Frailty Index And Fried Phenotype In Older Women, Jedd Pratt, Abadi K. Gebre, Carlos J. Toro-Huamanchumo, Elsa Dent, Trent Bozanich, Wai E. Lim, Elizabeth Byrnes, Julee Mcdonagh, Caleb Ferguson, Craig Sale, Kun Zhu, Carl Schultz, Richard L. Prince, Joshua R. Lewis, Marc Sim

Research outputs 2022 to 2026

Despite the nexus between cardiovascular health and frailty, the relevance of high-sensitivity cardiac troponin I (hs-cTnI), a biomarker of myocardial injury, to frailty is poorly understood. We examined whether hs-cTnI concentrations were associated with frailty in a well-characterized cohort of older women. A total of 1151 community-dwelling women from the Perth Longitudinal Study of Aging Women (mean age ± SD = 75.2 ± 2.7 years) were included. Frailty was operationalized using a validated frailty index (FI) of cumulative deficits and a modified Fried phenotype. Plasma hs-cTnI were categorized into quartiles. Cross-sectional associations between hs-cTnI quartiles and frailty were assessed using …

Smart Recurring Payment Auditor For Bait-And-Switch Mitigation, Prajna Shetty, Alok Roy

Defensive Publications Series

The present disclosure relates to the field of digital payment security, in particular to a system and method for mitigating bait-and-switch practices in recurring digital payment systems. The smart recurring payment auditor disclosed herein operates at a network layer of the payment infrastructure. The smart recurring payment auditor employs a multi-modal deep learning ensemble, advanced bitmapped feature encoding and temporal pattern synthesis to analyse recurring payment behaviour. Further, the smart recurring payment auditor integrates global merchant telemetry, user behavioural feedback, and descriptor intelligence to detect and score deceptive recurring billing schemes. Furthermore, upon identification of a suspicious pattern, the smart …

System And Method For Distributed Ai Model Processing Using Commodity Graphic Accelerators With Intelligent Workload Orchestration, Shreyas Kc, Yu Gu

Defensive Publications Series

This present disclosure relates to the field of Artificial Intelligence (AI), in particular to a system and method for distributed AI model processing using commodity graphic accelerators with intelligent workload orchestration. A system and method are provided for registering and utilizing commodity hardware equipped with graphic accelerators for distributed Artificial Intelligence (AI) model inference in both batch and real-time processing environments. The system comprises a hardware registration module for onboarding GPUs and other graphic accelerators, an AI model registration module for cataloguing models and their specifications, and an AI-based orchestration agent that analyses model characteristics, including complexity, data volume, feature …

Replay Time Based Cleanup Cache, R V Vighnesh

Defensive Publications Series

The present disclosure relates to the field of data processing, in particular to a time-based cleanup cache for optimizing deduplication in transaction processing systems. The cache organizes deduplication entries based on transaction dates and maintains only a minimal composite key required for unique identification, thereby improving both memory utilization and operational efficiency. The cache employs a deterministic cleanup process, wherein expired entries are automatically removed at predefined intervals, ensuring consistent performance and scalability under varying traffic conditions. Further, the cache is integrated into existing statestore workflows for replay validation and includes configurable capacity constraints, thereby enhancing service reliability, reducing infrastructure …