Digital Commons Network^™

Randomized Phase 2 Trial Of Tremelimumab And Durvalumab In Combination Versus Sequentially In Recurrent Platinum-Resistant Ovarian Cancer, Emily M Hinchcliff, Anne Knisely, Naomi Adjei, Bryan Fellman, Ying Yuan, Ami Patel, Cai Xu, Shannon N Westin, Anil K Sood, Pamela T Soliman, Aaron Shafer, Nicole D Fleming, David M Gershenson, Raghunandan Vikram, Tharakeswara Bathala, David Vining, Dhakshina M Ganeshan, Karen H Lu, Charlotte C Sun, Larissa A Meyer, Amir A Jazaeri

Faculty, Staff and Student Publications

BACKGROUND: Single-agent immune checkpoint inhibitors (ICIs) have demonstrated limited responses in recurrent ovarian cancer; however, 30%-40% of patients achieve stable disease. The primary objective was to estimate progression-free survival (PFS) after sequential versus combination cytotoxic T-lymphocyte antigen 4 and programmed death ligand 1 ICIs in patients with platinum-resistant high-grade serous ovarian cancer (HGSOC).

METHODS: Patients were randomized to a sequential arm (tremelimumab followed by durvalumab on progression) or a combination arm (tremelimumab plus durvalumab, followed by durvalumab) via a Bayesian adaptive design that made it more likely for patients to be randomized to the more effective arm. The primary end …

Temporal Changes In Treatment And Late Mortality And Morbidity In Adult Survivors Of Childhood Glioma: A Report From The Childhood Cancer Survivor Study, Peter M K De Blank, Katharine R Lange, Mengqi Xing, Sedigheh Mirzaei Salehabadi, Deokumar Srivastava, Tara M Brinkman, Kirsten K Ness, Kevin C Oeffinger, Joseph Neglia, Kevin R Krull, Paul C Nathan, Rebecca Howell, Lucie M Turcotte, Wendy Leisenring, Gregory T Armstrong, M Fatih Okcu, Daniel C Bowers

Faculty, Staff and Student Publications

Pediatric glioma therapy has evolved to delay or eliminate radiation for low-grade tumors. This study examined these temporal changes in therapy with long-term outcomes in adult survivors of childhood glioma. Among 2,501 5-year survivors of glioma in the Childhood Cancer Survivor Study diagnosed 1970-1999, exposure to radiation decreased over time. Survivors from more recent eras were at lower risk of late mortality (≥5 years from diagnosis), severe/disabling/life-threatening chronic health conditions (CHCs) and subsequent neoplasms (SNs). Adjusting for treatment exposure (surgery only, chemotherapy, or any cranial radiation) attenuated this risk (for example, CHCs (1990s versus 1970s), relative risk (95% confidence interval), …

Disease Progression, Survival, And Molecular Disparities In Black And White Patients With Endometrioid Endometrial Carcinoma In Real-World Registries And Gog/Nrg Oncology Randomized Phase Iii Clinical Trials, Zachary A Kopelman, Chunqiao Tian, Jordyn Tumas, Neil T Phippen, Christopher M Tarney, Erica R Hope, Stuart S Winkler, Suzanne Jokajtys, Calen W Kucera, John K Chan, Michael T Richardson, Daniel S Kapp, Chad A Hamilton, Charles A Leath, Nathaniel L Jones, Rodney P Rocconi, John H Farley, Angeles Alvarez Secord, Casey M Cosgrove, Matthew A Powell, Ann Klopp, Joan L Walker, Gini F Fleming, Nicholas W Bateman, Thomas P Conrads, G Larry Maxwell, Kathleen M Darcy

Faculty, Staff and Student Publications

OBJECTIVE: Investigate racial disparities in outcomes and molecular features in Black and White patients with endometrioid endometrial carcinoma (EEC).

METHODS: Black and White patients diagnosed with EEC who underwent hysterectomy ± adjuvant treatment in SEER, National Cancer Database (NCDB), the Genomics Evidence Neoplasia Information Exchange (GENIE) project (v.13.0), and eight NCI-sponsored randomized phase III clinical trials (RCTs) were studied. Hazard ratio (HR) and 95% confidence interval (CI) were estimated for cancer-related death (CRD), non-cancer death (NCD), and all-cause death.

RESULTS: Black (n = 4397) vs. White (n = 47,959) patients in SEER had a HR (95% CI) of 2.04 (1.87-2.23) …

Oral Decitabine And Cedazuridine Plus Venetoclax For Older Or Unfit Patients With Acute Myeloid Leukaemia: A Phase 2 Study, Alexandre Bazinet, Guillermo Garcia-Manero, Nicholas Short, Yesid Alvarado, Alex Bataller, Tareq Abuasab, Rabiul Islam, Kathryn Montalbano, Ghayas Issa, Abhishek Maiti, Musa Yilmaz, Nitin Jain, Lucia Masarova, Steven Kornblau, Elias Jabbour, Guillermo Montalban-Bravo, Caitlin R Rausch, Sherry Pierce, Courtney D Dinardo, Tapan Kadia, Naval Daver, Marina Konopleva, Xuelin Huang, Hagop Kantarjian, Farhad Ravandi

Faculty, Staff and Student Publications

Background: Hypomethylating agents combined with venetoclax are effective regimens in patients with acute myeloid leukaemia who are ineligible for intensive chemotherapy. Decitabine and cedazuridine (ASTX727) is an oral formulation of decitabine that achieves equivalent area-under-curve exposure to intravenous decitabine. We performed a single centre phase 2 study to evaluate the efficacy and safety of ASTX727 plus venetoclax.

Methods: This study enrolled patients with newly diagnosed (frontline treatment group) acute myeloid leukaemia who were ineligible for intensive chemotherapy (aged ≥75 years, an Eastern Cooperative Oncology Group [ECOG] performance status of 2-3, or major comorbidities) or relapsed or refractory acute myeloid leukaemia. …

Trajectories Of Health Care Contact Days For Patients With Stage Iv Non-Small Cell Lung Cancer, Arjun Gupta, Paul Nguyen, Danielle Kain, Andrew G Robinson, Amit A Kulkarni, David H Johnson, Carolyn J Presley, Anne H Blaes, Gabrielle B Rocque, Ishani Ganguli, Christopher M Booth, Timothy P Hanna

Faculty, Staff and Student Publications

Importance: Patients with stage IV non-small cell lung cancer (NSCLC) experience substantial morbidity and mortality. Contact days (ie, the number of days with health care contact outside the home) measure how much of a person's life is consumed by health care, yet little is known about patterns of contact days for patients with NSCLC.

Objective: To describe the trajectories of contact days in patients with stage IV NSCLC and how trajectories vary by receipt of cancer-directed treatment in routine practice.

Design, setting, and participants: A retrospective, population-based decedent cohort study was conducted in Ontario, Canada. Participants included adults aged 20 …

Thematic Analysis Of Alzheimer's Medication Management Discussion In A Non-Moderated Online Forum, Jia Liu, Kylie Meyer, Ashlie Glassner, Mitzi Gonzales, Rebecca J Bartlett Ellis, Hyejin Park, Lixin Song, Neela Patel, Jing Wang

Faculty, Staff and Student Publications

Background: Managing medications for Alzheimer's disease and related dementias is challenging for caregivers. Information about caregivers' strategies to manage these challenges is needed to inform intervention development.

Objective: This study aimed to understand caregivers' medication management experiences by analyzing online community discussions.

Methods: Posts were extracted from the ALZConnected® Forum using keywords "medication" and "drug" via web scraping. The researchers applied thematic analysis.

Results: Four major themes emerged: (1) role transition of medication management responsibilities, (2) caregivers' uncertainty about medication purpose and values, (3) conflicts between the care recipients and caregivers, and (4) difficulty accessing and affording medications.

Conclusions: The …

Efficient Photocatalytic Core–Shell Synthesis Of Titanate Nanowire/Rgo, Xiaofang Ye, Yang Tian, Mengyao Gao, Fangjun Cheng, Jinshen Lan, Han Chen, Mark Lanoue, Shengli Huang, Z. Ryan Tian

Chemistry & Biochemistry Faculty Publications and Presentations

Wide bandgap semiconductor-based photocatalysts are usually limited by their low solar energy conversion efficiency due to their limited absorption solar wavelength, their rapid surface recombination of the photogenerated electron–hole pairs, and their low charge-carrier mobility. Here, we report a novel stepwise solution synthesis for achieving a new photocatalytic core–shell consisting of a titanate nanowire/reduced graphene oxide shell (or titanate/rGO) 1D-nanocomposite. The new core–shell nanocomposite maximized the specific surface area, largely reduced the charge transfer resistance and reaction energy barrier, and significantly improved the absorption of visible light. The core–shell nanocomposites’ large on/off current ratio and rapid photo-responses boosted the photocurrent …

The Blurry Line Between Corporation And Cult: A Retrospective Autoethnographic Study, Ernst Graamans

The Qualitative Report

In popular management literature corporations are sometimes loosely compared to cults. The comparison is a severe allegation as it implies the transgression of subordinate employees’ integrity. This paper explores to what extent such comparisons with cults are warranted as well as the implications this has for the practice of corporate culture management. On grounds of the author’s unique, first-hand experience in both corporate and cultic environments a retrospective autoethnographic (RAE) approach was chosen to further explore the supposed resemblance. The comparison is structured along Lifton’s eight criteria of thought reform and reveals that although akin to cults in all aspects …

Contributions Of Barad's New Materialism To Well-Being Research, M. Isidora Bilbao-Nieva, Alejandra Meyer

The Qualitative Report

In this article, we discuss the contributions that Karen Barad's theorizations can make to the study of well-being, particularly their ontoepistemological framework, “agential realism,” that emphasizes the inseparability of matter, ethics, and knowledge, as the relational entanglements of agencies. We use these ideas to imagine well-being as differential materializations, entanglements of human, and the non-human agencies that “intra-act” with each other and are inseparable from how we know about them and our responsibilities in their reconfigurations. From this perspective, we see well-being as a phenomenon, underpinning its dynamism and processuality. Analyzing an interview fragment, we exemplify how Barad's theorizations can …

Mutualism As Mutual Trust: An Ethnographic Case Study On An Elementary-School Teacher-Team Participation In A Science Pd Program, Olga Gould-Yakovleva, Xiufeng Liu

The Qualitative Report

This grounded in social constructivism yearlong ethnographic case study was conducted at the final stage of a larger, longitudinal, multisite, and multi-year project. The current research focused on a group of urban public elementary schoolteachers who volunteered to participate in the National Science Foundation (NSF)-funded interdisciplinary science and engineering partnership (ISEP) project. These teachers were enrolled in the professional development (PD) college courses in physics and engineering design, summer research in university laboratories, and interdisciplinary science inquiry (ISI) pedagogy sessions. This research sought to understand the factors which contributed to successful teamwork at the elementary school under investigation. Additionally, this …

The Emotional Impact Of Sensitive Topics: An Autoethnographic Account Of An Ovarian Cancer Research, Dinah A. Tetteh

The Qualitative Report

Growing evidence suggests that qualitative research about sensitive topics is emotional work with varied unanticipated risks for researchers. This autoethnographic essay adds to the extant literature by discussing the complexities added when the research topic is sensitive, and the researcher has not personally experienced the topic under study. I reflect on and analyze epiphanies in my research with 28 ovarian cancer survivors in northwest Ohio and southern Michigan in the United States, including how I processed the death of some participants. I suggest that practicing active listening, reflexivity, and flexibility can help manage limitations of a research project of this …

Intraprocedural Versus Initial Follow-Up Minimal Ablative Margin Assessment After Colorectal Liver Metastasis Thermal Ablation: Which One Better Predicts Local Outcomes?, Yuan-Mao Lin, Iwan Paolucci, Jessica Albuquerque Marques Silva, Caleb S O'Connor, Bryan M Fellman, Aaron K Jones, Joshua D Kuban, Steven Y Huang, Zeyad A Metwalli, Kristy K Brock, Bruno C Odisio

Faculty, Staff and Student Publications

Objectives: The aim of this study was to investigate the prognostic value of 3-dimensional minimal ablative margin (MAM) quantified by intraprocedural versus initial follow-up computed tomography (CT) in predicting local tumor progression (LTP) after colorectal liver metastasis (CLM) thermal ablation.

Materials and methods: This single-institution, patient-clustered, tumor-based retrospective study included patients undergoing microwave and radiofrequency ablation between 2016 and 2021. Patients without intraprocedural and initial follow-up contrast-enhanced CT, residual tumors, or with follow-up less than 1 year without LTP were excluded. Minimal ablative margin was quantified by a biomechanical deformable image registration method with segmentations of CLMs on intraprocedural preablation …

Survival Outcomes And Toxicity Of Adjuvant Immunotherapy After Definitive Concurrent Chemotherapy With Proton Beam Radiation Therapy For Patients With Inoperable Locally Advanced Non-Small Cell Lung Carcinoma, Kelsey L Corrigan, Ting Xu, Yuki Sasaki, Ruitao Lin, Aileen B Chen, James W Welsh, Steven H Lin, Joe Y Chang, Matthew S Ning, Saumil Gandhi, Michael S O'Reilly, Carl M Gay, Mehmet Altan, Charles Lu, Tina Cascone, Efstratios Koutroumpakis, Ajay Sheshadri, Xiaodong Zhang, Li Liao, X Ronald Zhu, John V Heymach, Quynh-Nhu Nguyen, Zhongxing Liao

Faculty, Staff and Student Publications

Introduction: Adjuvant immunotherapy (IO) following concurrent chemotherapy and photon radiation therapy confers an overall survival (OS) benefit for patients with inoperable locally advanced non-small cell lung carcinoma (LA-NSCLC); however, outcomes of adjuvant IO after concurrent chemotherapy with proton beam therapy (CPBT) are unknown. We investigated OS and toxicity after CPBT with adjuvant IO versus CPBT alone for inoperable LA-NSCLC.

Materials and methods: We analyzed 354 patients with LA-NSCLC who were prospectively treated with CPBT with or without adjuvant IO from 2009 to 2021. Optimal variable ratio propensity score matching (PSM) matched CPBT with CPBT + IO patients. Survival was estimated …

Juggling Academic Practice And Care: Collaborative Autoethnography Within A Basque University Research Group, Asunción Martínez-Arbelaiz, Aingeru Gutierrez-Cabello, Estibaliz Aberasturi-Apraiz, Jose M. Correa-Gorospe

The Qualitative Report

Many university scholars, including the authors of this article, acknowledge that they feel like they are riding an emotional roller coaster with academic success, as well as many project failures. Except for our PhD thesis, many of us complete our research tasks in relatively established research groups. However, little research has examined the potential these groups might have to mitigate feelings of academic isolation. To fill in this gap, we designed two methodological steps. First, we adopted the Woolfian metaphor of a room of our own, where we composed individual vignettes regarding our feelings of isolation. We read each other's …

Performance Characteristics Of The 5-Ring Ge Discovery Mi Pet/Ct Scanner Using Aapm Tg-126 Report, Refaat Y Almazrou, Shadei F Alanazi, Mohammed H Alzaid, Razan S Al-Fakhranee, Shanli Ding, Osama R Mawlawi

Faculty, Staff and Student Publications

AIM: To report on the performance characteristics of the 5-ring GE Discovery MI PET/CT systems using the AAPM TG-126 report and compare these results to NEMA NU 2-2012 where applicable.

MATERIALS AND METHODS: TG-126 testing was performed on two GE 5-Rings Discovery MI scanners. Tests performed included spatial resolution, PET/CT image-registration accuracy, sensitivity, count rate performance, accuracy of corrections, image contrast, scatter/attenuation correction, and image uniformity. All acquired data were analyzed using scanner console or free software tools as described by TG-126 and the results were then compared to published NEMA NU 2-2012 values.

RESULTS: Both scanners gave similar resolution …

A Computer Vision Solution To Cross-Cultural Food Image Classification And Nutrition Logging​, Rohan Sethi, George K. Thiruvathukal

Computer Science: Faculty Publications and Other Works

The US is a culturally and ethnically diverse country, and with this diversity comes a myriad of cuisines and eating habits that expand well beyond that of western culture. Each of these meals have their own good and bad effects when it comes to the nutritional value and its potential impact on human health. Thus, there is a greater need for people to be able to access the nutritional profile of their diverse daily meals and better manage their health. A revolutionary solution to democratize food image classification and nutritional logging is using deep learning to extract that information from …

Clearing The Path: Improving Implementation Of Georgia’S Pathways To Coverage Program, Nicholas Smith

Emory Law Journal Online

Georgia’s Medicaid program is in flux. The State recently launched Pathways to Coverage, a partial Medicaid expansion program for non-disabled adults in households under 100% of the Federal Poverty Line, with eligibility contingent on reporting 80 hours of work per month. Pathways’ rollout coincides with Medicaid “unwinding,” an ongoing post-COVID redetermination process in which thousands of Georgians have already lost coverage. As such, Pathways could play an important role in offsetting the unwinding’s disenrollment effects. But Pathways may also serve as a test case for conservative lawmakers hoping to institute (or reinstitute) work requirements to restrict Medicaid coverage in their …

Automated Glacier Classification In High Mountain Asia Using Machine Learning And A Random Forest Classifier, Victoria Elizabeth Halvorson

Dartmouth College Master’s Theses

High Mountain Asia (HMA) is home to the largest mass of glaciers and ice outside the north and south polar regions. HMA glaciers are projected to experience accelerated mass loss from higher greenhouse gas emissions through the end of the century. Many studies of glacier mass balance and mass loss in HMA obtain glacier area from the Randolph Glacier Inventory (RGI). However, the RGI is designed to show glacier area across the world that is accurate to the year 2000 and, as a result, is not an accurate representation of the current state of glacier area in HMA. Additionally, glacier …

A Loon On Highland Lake, An Eco-Fantasy, Erin E. Bennett

Dartmouth College Master’s Theses

A Loon on Highland Lake is a fantasy play, adapted from Tchaikovsky’s ballet, Swan Lake, itself an adaption of a Russian “swan maiden” folktale. In this retelling, the spirit of an invasive tree species, Alder Buckthorn, endangers the inhabitants of the small lake town of East Andover, New Hampshire. On the night of the 4^th of July, Buckthorn places a curse on an unfortunate news reporter, transforming him into a loon, the solitary black bird known in the northeast for its distinct, haunting call. Figgy, a shy ecologist living in East Andover, stumbles upon the knowledge that her …

Admissions Magazine Spring 2024, Embry-Riddle Aeronautical University

Admissions Magazine

Altitude: Students Take A Giant Leap Forward

• Science That Works
• Education At A Higher Altitude: At Embry-Riddle Aeronautical University, Daring to Think Big and Push Boundaries Is A Way Of Life
• A Crash Course In Safety
• The Perfect Fit
• Seizing the Moment
• Broadened Perspectives
• The Perfect Bond
• Don't Let the Bed Bugs Bite
• A Well-Balanced Education
• Mechanical Engineering Major Looks to Make Environmental Impact
• Molecular Level Science
• Not An Optical Illusion
• Asia Campus Lab Advances Uncrewed Systems Training
• A Giant Leap Forward
• Getting His Hands on the Future
• An Additive Experience
• Space Launch System
• The M-Star Program
• A Giant Leap …

Investigating Essential Oils, Natural Compounds, And Marine Based Rumen Buffers As Feed Additives For Enteric Methane Mitigation And Improved Ruminant Productivity, Ian Hodge

Theses

Ruminant dietary additives were investigated for enteric methane (CH4) mitigation and their effects on rumen fermentation characteristics during both in vitro and in vivo supplementation trials. A meta-analysis of the peer reviewed published literature was initially performed to establish the state of the art in the field and allowed benchmarking of the performance of the dietary additives screened during the project. Investigated feed additives included garlic oil (GO), nitrate, Ascophyllum nodosum (AN), Asparagopsis (ASP), Lactobacillus plantarum (LAB), calcareous marine algae (CMA), chitosan (CHI), essential oils (EO) and 3-nitrooxypropanol (3-NOP). The development of an in vitro screening method to evaluate the …

The Need For Fentanyl-Specific Drug Education In Schools, Emma Guggenheimer

Cardozo Journal of Equal Rights & Social Justice

The note advocates for the implementation of state legislation requiring fentanyl-specific drug education in K-12 schools to combat the escalating opioid epidemic, particularly among teenagers. It emphasizes the critical role of schools in providing comprehensive education to raise awareness about the dangers of fentanyl and prevent overdose deaths. The proposal includes mandates for fentanyl-awareness campaigns, updated curricula, and the use of tools like fentanyl test strips and naloxone in schools.

Development Of A 3d-Printed Device To Study How Bacteria Alters The 3d Migration Of Breast Cancer Cells, Jack Bedell

Honors Capstones

No abstract provided.

Addressing The Opioid Crisis Through County-Widen Public Safety Agencies’ Post-Overdose Outreach Programs, Julia Keane

School of Professional Studies

The opioid epidemic not only kills thousands every year but sees thousands survive overdoses only to overdose again in a continuous cycle. Massachusetts is no stranger to this epidemic, with numbers and patterns mirroring national rates. Newer changes to the drug supply, with fentanyl becoming increasingly used, sold, and cut with other drugs., have been on the rise and impact current opioid overdoses rates. Preventative measures are needed to address this public safety and public health crisis, not only bettering the current rates but decreasing future ones. This paper will first look at the methodology and literature used to understand …

Identity-Driven Targeted Violence: Attending To Identity, Emotion, And Personality-Related Predictors Of Attitudinal And Behavioral Prejudice, Patrick Timothy Mcgonigal

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Identity-driven targeted violence driven by gender identity, sexuality, race, and religion overwhelmingly impacts marginalized groups of individuals. Existing evidence suggests that acts of bias on college campuses are often unreported by students, leaving those who engage in these behaviors to continue without proper redress. A great wealth of data illustrates the deleterious impacts of identity-driven behavior on student victims, including heightened psychological distress, poorer academic performance, and lower retention. In contrast, limited research has examined relevant underpinnings of perpetrating identity-driven harassment. The current dissertation developed and disseminated a large survey to undergraduate students spanning three years of data collection. The …

Second Order Effects In Concrete Insulated Wall Panels, Salam A. Al-Rubaye

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Insulated concrete panels (CIPs) have been used for over 60 years for their both structural and thermal resistance. The flexural behavior of CIPs has been investigated in recent years. The CIPs are rapidly becoming ubiquitous in the precast industry, and the tilt-up industry is initiating a study to determine their effectiveness as a tilt-up product. There are several known challenges associated with a tilt-up version of a partially composite wall and likely other unknown challenges. This study was initiated to investigate the behavior of load-bearing concrete insulated wall panels for use in tilt-up construction. The primary objective was to understand …

The Teacher Acute Concussion Tool And Return To Learn In West Virginia, Samantha Jane Windisch

Graduate Student Scholarship

Due to the complex nature and varying presentations of concussions or mild TBIs, multiple health categories are often involved in the recovery of post-concussion symptoms including physical, cognitive, emotional, and behavioral health concerns. The neurological side effects, along with the potential involvement of other health domains can propagate decreased participation and engagement in meaningful occupations or impact the overall quality of performance of these activities. One of those activities is being able to return to learning in the classroom. West Virginia (WV) has been providing education and training on the Teacher Acute Concussion Tool (TACT) to school staff and personnel. …

Pilot Study: Effects Of Whole Body Vibrational Therapy On Equine Epaxial Muscle Soreness, Riley Leibeck

Undergraduate Honors Thesis Projects

Whole body vibrational therapy (WBV) is well-studied in people, but there is a paucity of research of its effect on horses. It is suggested that WBV use in horses increases performance, aids in recovery, and stimulates nerves, bones, and muscles in ways that normal exercise does not. The purpose of this pilot study was to determine if frequent WBV therapy sessions affect back soreness in horses using pressure algometry. Most sporthorses will experience back soreness in their careers, and it is regarded as one of the most common causes of poor performance in equine athletes. Five horses were measured for …

U.S. International Adoption Subsidies: Shining Light On The Dark History Of The Baby "Black Market", Rachel Briner

The International Law Review Association Student Forum

While international adoption is a beautiful concept in theory, it often leads to dark consequences. From its inception, human trafficking has enabled international adoptions. While the United States alone cannot dismantle the entire baby “black market” and the likely black market for children’s organs intertwined with it, the U.S. can remove its large contribution. By limiting the federal adoption subsidy to only domestic adoptions, the United States can ensure it only aids systems within its control and address the needs of its own children without homes more effectively. Many other authors have also noted various human trafficking and potential organ …

0887: Gwenyth E. Hood Collection, 1889-2023, Marshall University Special Collections

Guides to Manuscript Collections

Gwenyth Elise Hood was born on December 10, 1955, to Thomas Arthur Hood and Marion Louise Snee Hood in White Plains, NY, but moved with her family to Brandon, Vermont at the age of seven. She developed a love of reading and writing at an early age, discovering some favorite authors—Rudyard Kipling, Shakespeare, and J.R.R. Tolkien—at roughly the same time, in early adolescence. Then came Dante. Dante drew her to learn Latin and Italian; she had already started on French due to family heritage and the availability of the language in High School. In 1979 she won a University of …