Digital Commons Network^™

Chromatin Insulators Homie And Nhomie Can Interact With Distant Copies Either Together Or Separately, With Distinct Outcomes For Enhancer-Promoter Interactions, Miki Fujioka, Wenfan Ke, Paul Schedl, James B. Jaynes

Department of Biochemistry and Molecular Biology Faculty Papers

Chromatin insulators, a.k.a. boundary elements, separate regions of the chromosome with distinct chromatin characteristics, including distinct histone modifications. This activity affects gene expression by allowing chromatin domains to be stably regulated and maintained. Insulators also block enhancer-promoter interactions and, somewhat paradoxically, facilitate other interactions, particularly when they stitch together distant regions of the chromosome by pairing with specific partners. Here we explore how long-range interactions facilitated by insulator pairing are affected by the presence of two potentially competing partners. Our results show that when two partners are present, they can reduce each other's effects on distant gene expression, suggesting that …

The Shrinking Caspian Sea: Eco-Hydrological Responses To Human And Climate Pressures, Jesse Duku, Mohammad J. Tourian, Marzi Azarderakhsh, Rovshan Abbasov, Ali Mehran, Ali Torabi Haghighi, Stefanos Xenarios, Azara Boschee, Salih Babagiray, Mojtaba Sadegh, Nima Shokri, Ali Nazemi, Alireza Farahmand, Samaneh Ashraf, Temur Khujanazarov, Elmira Hassanzadeh, Dalal Najib, Daniel Placht, Shamshagul Mashtayeva, For Full Author List, See Comments Below

Faculty Research, Scholarly, and Creative Activity

The Caspian Sea, the Earth's largest inland water body, faces water level decline, drawing comparisons to the collapse of the Aral Sea. Unlike the Aral Sea, the relative roles of climatic variability, hydrological changes, and anthropogenic pressures on the Caspian Sea remain poorly understood. Here, we integrate satellite observations, in situ hydrological records and reanalysis data to examine recent drivers of the Caspian water loss. We show that total river inflow to the Caspian Sea has declined significantly, primarily due to reduced discharge from the Volga River. At the same time, precipitation over the basin has remained broadly stable, while …

Phasing Out A Way Of Life: How Decarbonization Affects Coal Dependent Communities, Alex Loeb

Duke Environmental Law & Policy Forum

As member states seek to comply with European Union industry rationalization directives that will force mines that cannot compete with free-market prices without subsidies to close, domestic governments across Europe will face competing pressure from civil society. Many traditional European mining communities are dependent on the coal industry and will resist the phase out of its position in the European energy mix. In Asturias, Spain, the phase out of non-competitive coal mines has had devastating impacts on former mining towns, as they struggle to transition to a coal-free economy. After phasing out coal, Asturias has struggled with unemployment and significant …

Statistical Methods In Research, Horahenage Dixon Vimalajeewa

UNL Faculty Course Portfolios

This course portfolio documents the design, delivery, assessment, student-learning evidence, and reflective evaluation of STAT 801A-700: Statistical Methods in Research, an online asynchronous service course designed to introduce students from diverse disciplinary backgrounds to foundational statistical reasoning and applied data analysis. The course is a non-calculus-based introduction to statistical methods used to answer research questions, with emphasis on collecting, organizing, describing, analyzing, and drawing conclusions from data. The course also emphasizes applications relevant to biology, agriculture, and other research-oriented fields. This is an online distance course aimed to develop students’ understanding of basic probability and statistical concepts, recognize the importance …

Course Portfolio: Elements Of Physics Phys 151, Evan A. Rich

UNL Faculty Course Portfolios

This course portfolio documents the instructional design, teaching methods, and ongoing assessment efforts for PHYS 151: Elements of Physics, an algebra-based introductory physics course at the University of Nebraska-Lincoln. The course serves a broad undergraduate population, including architecture, construction management, and life science majors. The portfolio describes the teaching framework that integrates pre-lecture video preparation, active in-class engagement through iClicker questions, and collaborative weekly recitation sections, all unified around a structured six-step problem-solving approach. A central concern of the course is building students’ self-efficacy in physics, particularly among those with math anxiety or limited preparation. Two assessments are reported: a …

‘Wala Kaming Alam Sa Stroke Care’ (We Don’T Know Anything About Stroke Care): Experiences Of Care Providers Delivering Stroke Rehabilitation Care In The Philippines, Fiona Leggat, Sarah Ann Buckingham, Aira Patrice Rueda Ong, Bridie Kent, Nena Marie Santos, Annah Teves, Vergil Boac, Paula Melizza Valera, Elda Anota, Maria Mercedes Barba, Myrna Estrada, Neil Bryan Pita, Alyssa Dar Juan, Lorraine Faeldon, Fiona Jones

School of Nursing and Midwifery

BackgroundIn the Philippines, rising stroke prevalence and healthcare inequalities present a concerning outlook. While acute stroke care is prioritised, rehabilitation remains undervalued. The experiences of healthcare providers who deliver stroke support are also under-researched.Objective(s)Our study aimed to explore the experiences and needs of care providers across multiple regions of the Philippines to inform the development of stroke support initiatives and programmes.MethodsForming part of the Tulong, Ugnayan ng Lingap At gabaY (TULAY) project, a qualitative descriptive design involving semi-structured interviews was used. Care providers with professional or voluntary community healthcare service delivery roles were recruited. Data were analysed using reflexive thematic …

Disease-Causing Mfn2 Mutants Impair Mitochondrial Fission Dynamics By Distinct Drp1 Dysregulation, Daniel Lagos, Pamela R. De Santiago, Nicolás Pérez-Bravo, Benjamín Cartes-Saavedra, Josefa Vial-Brizzi, Diego Troncoso-Chandía, Oliver Podmanicky, Rita Horvath, Verónica Eisner

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Mitochondria undergo fusion and fission. While DRP1 regulates fission, fusion is controlled by OPA1, MFN1, and MFN2. The balance between these processes and the crosstalk between machineries remains poorly understood. MFN2 mutations cause Charcot-Marie-Tooth disease type 2 A (CMT2A), affecting mitochondrial fusion and morphology. However, their role in fission is unclear. Using skin fibroblasts from CMT2A patients (L248H and M376V MFN2 mutations) and wild-type mouse embryonic fibroblasts expressing these variants, we studied how MFN2 mutations impact mitochondrial dynamics beyond fusion. We analyzed mitochondrial morphology and dynamics by live-cell confocal microscopy and tested fusion/fission protein levels, oxygen consumption rate (OCR), extracellular …

Detectability Of Polarized Γ-Ray Emission From Blazar Flares With Cosi, Garrett A. Latiolais, Jorge Otero-Santos, Michela Negro, Lea Marcotulli, Mohammad Ali Boroumand, Savitri Gallego, Tiffany Lewis, Et Al.

Michigan Tech Publications

We investigate the detectability of polarized γ-ray emission from blazar flares with the Compton Spectrometer and Imager (COSI). Using 17 yr of Fermi Large Area Telescope observations, we analyze light curves for 1413 blazars and identify a maximum of 787 sources with flaring episodes through Bayesian block analysis. For each flare, we estimate the minimum detectable polarization (MDP99%) in the COSI energy band (0.2–5 MeV) using instrument response functions under a range of spectral assumptions and background conditions. Under baseline background levels (1 count s⁻¹) and assuming that blazar flare statistics in the MeV band are comparable to …

Chatgpt, Where Should I Go? A Qualitative Exploration Of How Large Language Models Are Experienced As Support For Travel Planning, Mohammad Amin Kuhail, Asbjørn Følstad, Saifeddin Alimamy

All Works

Large language models (LLMs) are increasingly used for travel planning. Yet, little is known about how travellers experience and interact with such language models. This qualitative study explores how users employ LLMs to plan trips, drawing on the hedonic/pragmatic model of user experience to examine functional and affective dimensions. We collected data from 104 participants with prior experience using LLMs for travel advice through open-ended questionnaire responses. Thematic analysis revealed three key insights: (1) users value the pragmatic benefits of LLMs, such as efficiency, clarity, and confidence in decision-making, while also appreciating hedonic qualities, including inspiration, enjoyment, and authenticity; (2) …

A Machine Learning Framework For Contractor Scope Matching Using Profile Characteristics And Work Package Vector Similarity, Pedro Fonseca, Sergei Chuprov

Computer Science Faculty Publications

This paper presents a machine learning-based framework for predicting contractor performance in the construction industry by integrating contractor profile information with work package characteristics. The proposed approach addresses procurement challenges arising from the misalignment between contractor expertise and assigned scopes, a key contributor to cost overruns and schedule delays. Unlike existing models that rely on aggregated project-level indicators, the framework enables scope-aware performance prediction by leveraging the Work Breakdown Structure (WBS) to capture similarity among work packages. Contractor profiles are encoded using historical performance data, while WBS elements are vectorized to quantify scope similarity and contextualize predictions. Experimental results demonstrate …

Exploring Strategies For Reducing Employee Turnover In Healthcare Facilities, Khaddy Jammeh

Walden Dissertations and Doctoral Studies

No abstract provided.

Synthesis And Characterization Of Synergistic Bioactive– Organometallic Condensation Polymers, Francesca Isabel Mosca

Electronic Theses and Dissertations 2020 - Present

This research focuses on the synthesis and structural characterization of polymers with anticipated anticancer and antiviral properties by combining metal-containing Lewis acids, organotin dichlorides (R2SnCl2), Group 4 metallocene dichlorides (Cp2TiCl2, Cp2ZrCl2 and Cp2HfCl2), and triphenyl Group 15 metal dichlorides (Ph3AsCl2, Ph3SbCl2 and Ph3BiCl2), with biologically active Lewis bases, lamivudine, a synthetic nucleoside, and camphoric acid, a dicarboxylic acid, to achieve synergistic effect.

Five classes of polymers were synthesized using interfacial polymerization: lamivudine and organotin dichlorides, lamivudine and Group 4 metallocene dichlorides, camphoric acid and triphenyl Group 15 metal dichlorides, camphoric acid and organotin dichlorides, and camphoric acid and Group 4 …

Synthesis And Characterization Of Organometallic Polymers And Their Cytotoxicity Towards Human Cancer Cell Lines, Paul Peter Slawek

Electronic Theses and Dissertations 2020 - Present

This research aimed to synthesize organometallic polymers from dialkyl (methyl, ethyl, butyl, cyclohexyl, and octyl) and diaryl (phenyl) tin dichlorides and three organic monomers, dipicolinic acid (DPA), chloramphenicol (CH), and isomannide (IS), using interfacial polymerization. Structure-activity relationships were investigated through physicochemical characterization (light-scattering photometry, proton NMR, and IR spectroscopy) and cytotoxicity was evaluated against six human cancer cell lines (AsPC-1, PANC-1, MCF-7, MDA-MB-231, HT-29, PC-3), with cisplatin serving as the reference standard.

Five DPA/tin polymers were synthesized, with IC₅₀ values in the range of 0.60–0.71 μg/mL. Their cytotoxicity was significantly lower than that of cisplatin (0.0023-0.044 μg/mL), suggesting that …

Discovery Of Bmi-Associated Gut Microbiome Signatures In The Awi-Gen 2 Cohort, Meriem Yagoubi

Theses and Dissertations

Obesity is increasing across sub-Saharan Africa amid rapid dietary, environmental, and urbanization transitions, yet the gut microbiome features associated with adiposity in African populations remain under-characterized. This study investigated whether species-level gut microbiome composition is associated with body mass index (BMI) in the AWI-Gen 2 cohort, and whether BMI-associated microbial signals remain detectable after accounting for the dominant geographic structure of the microbiome. Gut microbiome community structure and diversity were characterized across 1,665 participants, and differential abundance analysis was used to identify taxa associated with BMI after controlling for study site. Machine learning models were then trained to assess how …

Quantitatively Hyper-Positive Real Rational Functions Iii, Daniel Alpay, Izchak Lewkowicz

Mathematics, Physics, and Computer Science Faculty Articles and Research

Hyper-Positive Real, matrix-valued, rational functions are associated with absolute stability (the Lurie problem). Here, quantitative subsets of Hyper-positive functions, related through nested inclusions, are introduced. Structurally, this family of functions turns out to be matrix-convex and closed under inversion. A state-space characterization of these functions through a corresponding Kalman-Yakubovich-Popov Lemma, is given. Technically, the classical Linear Matrix Inclusions, associated with passive systems, are here substituted by Quadratic Matrix Inclusions.

Participants’ And Physiotherapists’ Views On The Delivery Of A Randomised Controlled Feasibility Trial Investigating A Bespoke Dynamic Elastomeric Fabric Orthosis For Women With Chronic Pelvic Girdle Pain: A Qualitative Exploration, Bradley Halliday, Jennifer Freeman, Sarah Chatfield, Lee Cameron, Kirsty Carter, Joanne Hosking, Jill Shawe

School of Health Professions

Background: Chronic pregnancy-related pelvic girdle pain (PPGP) affects approximately 10–30% of postpartum women beyond 3 months. Such pain is typically recalcitrant to standard care. A dynamic elastomeric fabric orthosis (DEFO) is one option. A feasibility randomised controlled trial (fRCT) assessed the feasibility and acceptability of trial design, interventions and data collection. The aim of this qualitative sub-study was to explore the experience of women participating in the feasibility trial, and physiotherapists delivering the trial intervention. Methods: An embedded qualitative study within a fRCT. The fRCT randomised participants to either control (standard care involving advice and exercise) or intervention (standard care …

Koba-Nielsen Local Zeta Functions, Convex Subsets, And Generalized Selberg-Mehta-Macdonald And Dotsenko-Fateev-Like Integrals, Willem Veys, Wilson A. Zuniga-Galindo

School of Mathematical & Statistical Sciences Faculty Publications

The Koba-Nielsen local zeta functions are integrals depending on several complex parameters, used to regularize the Koba-Nielsen string amplitudes. These integrals are convergent and admit meromorphic continuations in the complex parameters. In the original case, the integration is carried out on the n-dimensional Euclidean space. In this work, the integration is over a variety of (bounded or unbounded) convex subsets; the resulting integrals also admit meromorphic continuations in the complex parameters. We describe the meromorphic continuation's polar locus explicitly, using the technique of embedded resolution. This result can be reinterpreted as saying that the meromorphic continuations are weighted sums of …

Entre La Lucha: Familismo And Well-Being Of Latino Immigrant Families Navigating Manual Labor And Anti-Immigrant Sentiment, Faviola Robles Saenz

Dissertations and Theses

The United States' history of treatment toward Latino immigrants has been shaped by anti-immigrant sentiment and exploitative labor practices, creating psychological violence that harms their families' well-being. Although previous research has examined anti-immigrant sentiment, labor conditions, and familismo among Latinos, these areas are often studied in isolation, with limited attention to their intersections and how they are experienced across generations. Informed by history, prior research, and my lived experiences, this study qualitatively explored the intersections of anti-immigrant sentiment and parents' manual labor to understand how these contexts shape familismo and well-being among Latino immigrant families. This work was grounded in …

Expanding Transmobilities: Understanding Genderdiverse And Transgender Travel Behavior Through An Art-Informed Methodology, Nicholas Michael Puczkowskyj

Dissertations and Theses

Transgender and genderdiverse people face discrimination and harassment in public when making trips in Portland, OR. People who identify as genderdiverse or transgender create unique travel behavior due to the influence of their internalized and expressed gender identity and through interactions in public. This dissertation examines how gender identity influences the travel behavior of genderdiverse and transgender people and how these experiences influence their subjective wellbeing when making trips in Portland, Oregon. Traditional one-on-one interviews were conducted in conjunction with allowing the interviewees to produce art as a non-verbal form of expression and communication of their experiences making trips in …

The Shrinking Caspian Sea: Eco‐Hydrological Responses To Human And Climate Pressures, Jesse Duku, Mohammad J. Tourian, Marzi Azarderakhsh, Rovshan Abbasov, Ali Mehran, Ali Torabi Haghighi, Stefanos Xenarios, Azara Boschee, Salih Babagiray, Mojtaba Sadegh, Nima Shokri, Ali Nazemi, Alireza Farahmand, Samaneh Ashraf, Temur Khujanazarov, Elmira Hassanzadeh, Dalal Najib, Daniel Placht, Shamshagul Mashtayeva, Ekaterina Rets, Hamid Norouzi, Kaveh Madani, Manoochehr Shirzaei, Hossein Shafizadeh-Moghadam, Chiyuan Miao, Ali Mirchi, Shuo Wang, Amir Aghakouchak

Publications and Research

The Caspian Sea, the Earth's largest inland water body, faces water level decline, drawing comparisons to the collapse of the Aral Sea. Unlike the Aral Sea, the relative roles of climatic variability, hydrological changes, and anthropogenic pressures on the Caspian Sea remain poorly understood. Here, we integrate satellite observations, in situ hydrological records and reanalysis data to examine recent drivers of the Caspian water loss. We show that total river inflow to the Caspian Sea has declined significantly, primarily due to reduced discharge from the Volga River. At the same time, precipitation over the basin has remained broadly stable, while …

Empirical Analysis And Optimization Of Impingement Cooling-Jet-Geometry For Austempering Hot-Rolled Steel Using Computational Fluid Dynamics, Azubuike Michael Nwankwo, Thomas Okechukwu Onah, Bertrand Nduka Nwankwojike

Engineering and Technology Journal

This investigation evaluates stationary impingement cooling of two bio-based fluids on a rectangular steel plate (230 × 120 × 12 mm) using jet diameters of 10 mm and 40 mm across impingement gaps of 115–155 mm. The study addresses the critical need for sustainable cooling media in metallurgical processes while advancing fundamental understanding of bio-fluid jet impingement heat transfer through integrated experimental-computational methodology. ANSYS-based numerical simulations and parametric optimization assessed how jet diameter and impingement gap influence convective heat transfer coefficients and governing dimensionless parameters. Temperature–time data were analysed using lumped thermal mass methods, generating empirical correlations from Reynolds, Nusselt, …

[Birds-Of-A-Feather] A Tri-Level Roadmap To Ai-Ready Universities: Strategy, Operations, Deployment, Sarah Forzetting, Rochelle Lundy, Ahmad Pratama, Karryl Kim Sagun Trajano, Antara Chakraborthy, Yasmine Wong

FORCE 2026

This panel discussion by three institutions will offer three approaches to conceptualizing and supporting AI use at the national, local, and individual levels.

Nanyang Technological University will frame the discussion by examining AI as a social good, highlighting how even advanced initiatives such as Singapore’s face equity gaps that risk leaving vulnerable populations behind. The panelist will further outline how information professionals and other key stakeholders can play a critical role in bridging these gaps in the pursuit of widespread public AI literacy. Stanford University Libraries will outline difficulties institutions have in operationalizing guidelines to help researchers bring a project …

Developing An Assessment Framework To Support Critical Evaluation Of Ai-Powered Academic Search Engines, Huajin Wang

FORCE 2026

As AI-powered tools are emerging in all aspects of research, it’s challenging for researchers, students, and librarians alike to assess the benefit, usefulness, and risks associated with a new AI-powered tool or AI-enhanced features of an existing one. To address this challenge, Carnegie Mellon University Libraries is developing a Tool Evaluation Framework to help users understand how AI-powered tools work, initially focused on AI-enhanced academic search engines. By evaluating criteria such as mechanisms for document retrieval, processes for content generation, and the quality of outputs, this framework guides users to carefully consider the strengths and weaknesses of a tool before …

Supporting Fair Practices In Scholarly Publishing With The Editorial Reference Handbook, Susanna-Assunta Sansone, Allyson Lister, Rebecca Taylor-Grant, Matthew Cannon

FORCE 2026

Co-produced by academics and publishers (incl. CUP, Cell Press, EMBO Press, Taylor & Francis, GigaScience Press, OUP, PLOS, Springer Nature), the Editorial Reference Handbook (https://publishers.fairassist.org) assists scholarly publishers in supporting the sharing of digital research objects and in operationalising FAIR research practices by addressing gaps in editorial workflows, policy implementation and stakeholder alignment. The Handbook comprises three interrelated components—a checklist, detailed guidance documentation, and a flowchart—intended primarily for in-house editorial staff while also providing value to reviewers, authors, and service providers.

Beside this practical collaboratively developed product, the Handbook is also a socio-technical pilot to improve the culture …

Ten Years Of Tuwhera: A Commitment To Sustaining Open Access Publishing, Donna Coventry

FORCE 2026

Tucked away, far from the conference circuit, is a part of the world which doesn’t tend to make the headlines when it comes to open access initiatives. New Zealand and by extension, the South Pacific, is a region struggling with a history of colonisation and trying to make systematic change around decolonisation - open access to research about ‘our place in the world’ is vitally important. 

Ten years ago Auckland University of Technology’s library (Te Mātāpuna) made the decision to start hosting Diamond open access journals. Starting with two established journals, the service was named Tuwhera which can be translated …

Asian Open Research Data And Its Potential For Ai: Bridging The Digital Divide Through Strategic Data Sharing, Mark Hahnel, Simon Porter

FORCE 2026

The growing momentum for open research data in Asia intersects with global advances in artificial intelligence (AI). Open data policies and infrastructures are increasingly recognized as critical enablers of research equity, reproducibility, and innovation. This talk examines the current state of open academic data, highlights economic and scientific arguments for its adoption, and explores the transformative potential of Asian open data ecosystems in powering AI-driven discovery. Drawing on global examples such as the Protein Data Bank and emerging health datasets, the discussion positions Asian institutions to leverage open strategies that simultaneously meet compliance mandates, enhance visibility, and accelerate breakthroughs in …

Controversy Associated With Red-Light Traffic Cameras, Alan D. Smith, Anna Abdulmanova

Atlantic Marketing Association Proceedings

No abstract provided.

Managing Ai Bot Access To Open Scholarly Infrastructures, Petr Knoth

FORCE 2026

The rapid rise of generative AI has created unprecedented demand for large, high-quality research corpora. Open access repositories and other open scholarly infrastructures have therefore become primary sources for AI bots, because they host research that is not universally reliable, but remains far more evidence-based than most web content. This is both an opportunity and a strain: repositories are now more valuable than ever, but machine traffic brings sustainability, capacity and policy challenges. Repositories may be able to scale, but who should fund that scaling, and under what conditions?

The core dilemma is how to curb abusive high-load bot activity …

Beyond The Launch: Seven Years Of Sustaining An Open Educational Resource After The Grant Ends, Susan Gardner Archambault

FORCE 2026

This presentation shares seven years of lessons from maintaining Project CORA (Community of Online Research Assignments), an award-winning, open-access platform where librarians and educators share adaptable information literacy assignments. Launched in 2016 with grant support and strong community engagement, CORA saw early success: international page views across 150+ countries, 200+ shared assignments and teaching resources, and community-building features like "adapt this assignment" and leaderboards.

But when funding ended in 2018, Project CORA entered what many open projects experience but few discuss publicly: the precarious post-grant phase, when initial funding and enthusiasm fade but infrastructure still needs support. Annual contributions dropped …

Ab-Initio Investigation Of 2d Materials For Voc-Based Cancer Biomarker Detection And Hydrogen Storage Application, Ibrahim J.M. Alghoul

Thesis/ Dissertation Defenses

This dissertation is motivated by two driving forces:
(i) the need for biosensors for early cancer diagnosis, and
(ii) the need for hydrogen storage materials to support a future energy hydrogen-based economy.
Throughout this thesis, both challenges were addressed using computational methods based upon density functional theory (DFT), as implemented in the Vienna Ab-initio Simulation Package (VASP), ab-initio molecular dynamics (AIMD), and thermodynamic analysis.

On the side of cancer biomarker detection, exhaled breath containing volatile organic compounds (VOCs) have been shown to offer the analysis of a promising non-invasive diagnostic strategy. This thesis explored the functionalization of two distinct 2D …