Digital Commons Network^™

A Phase Ii Trial Of The Wee1 Inhibitor Adavosertib In Setd2-Altered Advanced Solid Tumor Malignancies (Nci 10170), Edward Maldonado, Nikolaos A Trikalinos, Et Al.

2020-Current year OA Pubs

UNLABELLED: We sought to evaluate the efficacy of WEE1 inhibitor adavosertib in patients with solid tumor malignancies (cohort A) and clear cell renal cell carcinoma (ccRCC; cohort B). NCT03284385 was a parallel cohort, Simon two-stage, phase II study of adavosertib (300 mg QDAY by mouth on days 1-5 and 8-12 of each 21-day cycle) in patients with solid tumor malignancies harboring a pathogenic SETD2 mutation. The primary endpoint was the objective response rate. Correlative assays evaluated the loss of H3K36me3 by IHC, a downstream consequence of SETD2 loss, in archival tumor tissue. Eighteen patients were enrolled (9/cohort). The median age …

Risk Factors For Postpartum Depression And Severe Distress Among Mothers Of Very Preterm Infants At Nicu Discharge., Julie A. Hofheimer, Elisabeth C. Mcgowan, Lynne M. Smith, Samantha Meltzer-Brody, Brian S. Carter, Lynne M. Dansereau, Steven Pastyrnak, Jennifer B. Helderman, Charles R. Neal, Sheri A. Dellagrotta, Thomas Michael D O'Shea, Barry M. Lester

Manuscripts, Articles, Book Chapters and Other Papers

OBJECTIVE:  To identify psychological, medical, and socioenvironmental risk factors for maternal postpartum depression (PPD) and severe psychological distress (SPD) at intensive care nursery discharge among mothers of very preterm infants.

STUDY DESIGN:  We studied 562 self-identified mothers of 641 infants born(NOVI) conducted in nine university-affiliated intensive care nurseries. Enrollment interviews collected socioenvironmental data, depression, and anxiety diagnoses prior to and during the study pregnancy. Standardized medical record reviews ascertained prenatal substance use, maternal and neonatal medical complications. The Edinburgh Postnatal Depression Scale and Brief Symptom Inventory were administered at nursery discharge to screen for PPD and SPD symptoms, respectively.

RESULTS: …

Psychotropic Medication Usage In Pediatric Ckd: Reporting From The Ckd In Children Cohort., Ryan C. Ward, Amy J. Kogon, Matthew B. Matheson, Anne Dawson, Stephen R. Hooper, Stephen Molitor, Cynthia Wong, Susan L. Furth, Bradley A. Warady, Lyndsay A. Harshman

Manuscripts, Articles, Book Chapters and Other Papers

Background: Mental health disorders within the pediatric CKD population are prevalent. The frequency is unknown with which psychotropic medications that commonly treat these conditions are used in this population.

Methods: Data from the CKD in Children (CKiD) cohort study were used to describe the use of psychotropic medications and patient-related characteristics of use. Medications were classified into three groups: antidepressants, central nervous system (CNS) stimulants, and antipsychotic/mood stabilizing medications. Participant age, sex, CKD severity, and duration of medication use were ascertained. Medication use was evaluated in parallel with CKD disease type, presence of urological comorbidity, and hypertension. Chi-square tests compared …

Metalogues, Robert Kelly

Robert Kelly Manuscripts

No abstract provided.

July 2024, Robert Kelly

Robert Kelly Manuscripts

No abstract provided.

Inpatient Staff Perspective On Verbal De-Escalation Within A High Acuity Population, Giovanna Dezutti

Dissertations

This study explored inpatient staff’s perspective of verbal de-escalation within a high acuity population as well as the factors that make either a positive or negative impact on the effectiveness of verbal de-escalation as used in high acuity impatient settings. This phenomenological study used semi-structured interviews of 5 participants working in this setting. Participants were recruited through snowball sampling, and interviews were conducted via zoom. This study found that participants unanimously agreed that the training they received regarding verbal de-escalation was not sufficient and that employment of certain personality traits and behaviors were more effective than using only the methods …

A Qualitative Study Exploring The Management & Implications Of Power Differentials Experienced By Pre-Licensed Supervisees In Clinical Supervision Settings, Joyti Jariwala

Dissertations

The focus in this qualitative study was to explore how power differentials in supervision create positive and negative experiences between licensed psychologists and pre-licensed doctoral students. The study results provide insight into how supervisees navigate these dynamics during supervision, which typically involves experiential learning environments in which trainees discuss progress, receive feedback, and enhance their skills. The theoretical framework grounding the study was social learning theory, which is based on the idea that individuals learn from modeling, observation, and imitation in a social context (Bandura, 1986). Reflexive thematic analysis was used to recognize similarities in findings gathered via two sets …

Generation Z’S Perspective On Work-Life Balance: Case Of Kosovo, Lorine Bajrami

Theses

This capstone project examines the perspective of Generation Z in Kosovo toward work-life balance by specifically looking at their preferences regarding flexibility, remote work, and the compromise of work-life balance with other work-related factors. People who are born between 1996 and 2010 belong to the Generation Z cohort, which is characterized by profound digital savviness, mental health awareness, preference for flexibility in workplace, and strong desire to balance work and personal life. The data for analyzing the Gen Z’s perspectives on life work-balance is collected through an online survey (n=174) and two focus group discussions. Global reports and existing research …

Impacts Of Professional Development On Researchers, Kayleigh M. Patterson

Theses

In this work, I study the effectiveness of Professional development for Emerging Education Researchers (PEER) using a framework adapted from one that evaluates professional development for teachers. Professional Development (PD) is the process of learning information after one’s main school for job settings. These cover job/career specific skills that are not taught during schooling, since they are normally more specific. While a Ph.D. does set up a lot of specific skills, due to a changing research climate based on discoveries and organizational standards, there are always more skills to learn for a researcher. Therefore, there are professional development for researchers …

Feasibility Of Simulation Free Abdominal Stereotactic Adaptive Radiotherapy Using An Expedited Pre-Plan Workflow, Alex T Price, Joshua P Schiff, Alice Silberstein, Robbie Beckert, Tianyu Zhao, Geoffrey D Hugo, Pamela P Samson, Eric Laugeman, Lauren E Henke

2020-Current year OA Pubs

BACKGROUND AND PURPOSE: Improved hounsfield-unit accuracy of on-board imaging may lead to direct-to-unit treatment approaches We aimed to demonstrate the feasibility of using only a diagnostic (dx) computed tomography (CT)-defined target pre-plan in an

MATERIALS AND METHODS: Eight patients with abdominal treatment sites (five pancreatic cancer, three oligometastases) were treated using an integrated adaptive O-Ring gantry system. Each patient's target was delineated on a dxCT. The target only pre-plan served primarily to seed the ART process. During the ART session, all structures were delineated. All simulated cases were treated to 50 Gy in 5 fractions to a planning target optimization …

Phase 1b Study To Assess The Safety, Tolerability, And Clinical Activity Of Pamiparib In Combination With Temozolomide In Patients With Locally Advanced Or Metastatic Solid Tumors, Agostina Stradella, Haeseong Park, Et Al.

2020-Current year OA Pubs

BACKGROUND: Pamiparib is a potent, selective, poly (ADP-ribose) polymerase 1/2 inhibitor that demonstrates synthetic lethality in cells with breast cancer susceptibility gene mutations or other homologous recombination deficiency. This two-stage phase 1b study (NCT03150810) assessed pamiparib in combination with temozolomide (TMZ) in adult patients with histologically confirmed locally advanced and metastatic solid tumors.

METHODS: Oral pamiparib 60 mg was administered twice daily. During the dose-escalation stage, increasing doses of TMZ (40-120 mg once daily pulsed or 20-40 mg once daily continuous) were administered to determine the recommended dose to be administered in the dose-expansion stage. The primary objectives were to …

Enacting Data Context: Fixing Meaning In Transparency Data Initiatives, Lindsay Poirier

Statistical and Data Sciences: Faculty Publications

This article documents the “context cultures” underpinning efforts to develop regulations for collecting and reporting data in a United States public database known as Open Payments. Open Payments is a dataset published annually by the US Center for Medicare and Medicaid Services that documents the transfers of value from pharmaceutical and medical device manufacturers to physicians, prescribing non-physicians, and teaching hospitals. In the article, I show context became a manifold concern as differentially-situated actors engaged in modes of public advocacy and social action around not only what data meant, but also what it meant to make data meaningful. I show …

Decentralized Clinical Trials For Medications To Reduce The Risk Of Dementia: Consensus Report And Guidance, Leanne Howard, Carla Abdelnour, Erin Abner, Ricardo F. Allegri, Hiroko H. Dodge, Serge Gauthier, Camilla M. Hoyos, Gregory Jicha, Patrick G. Kehoe, Catherine J. Mummery, Adesola Ogunniyi, Nikolaos Scarmeas, Xiaoying Chen, Jodie R. Titiner, Christopher R. Weber, Ruth Peters

Neurology Faculty Publications

INTRODUCTION: Recent growth in the functionality and use of technology has prompted an increased interest in the potential for remote or decentralized clinical trials in dementia. There are many potential benefits associated with decentralized medication trials, but we currently lack specific recommendations for their delivery in the dementia field.

METHODS: A modified Delphi method engaged an expert panel to develop recommendations for the conduct of decentralized medication trials in dementia prevention. A working group of researchers and clinicians with expertise in dementia trials further refined the recommendations.

RESULTS: Overall, the recommendations support the delivery of decentralized trials in dementia prevention …

A New Reporter Confronts The Supreme Court’S Unpublished Decisions, Peter W. Martin

Cornell Law Faculty Publications

In late January 2021, the Supreme Court of the United States issued a long list of orders. It concluded with a single sentence: “It is ordered that Rebecca Anne Womeldorf be appointed Reporter of Decisions of this Court . . . , effective January 25, 2021, . . . charged with the duty of reporting the decisions of the present Term which have not been reported prior to January 25, 2021.” The order was silent about the immense challenge facing the new Reporter in the form of unpublished decisions from prior terms. Actions taken by Ms. Womeldorf and her staff, …

Llu Dentistry - Volume 33, Number 2, Loma Linda University School Of Dentistry

Articulator (Dentistry)

In this issue:

4 | Dean's Message
5 | 39th Annual Children's Day
6 | Leading the Way: The Journey of an RDAEF Program Director
8 | Charles Goodacre, DDS'71, MSD - Fellowship in the Royal College of Surgeons and Dr. Thaddeus V. Weclaw Award
9 | LLU Shines with Silver at Men's NCPA National Pickleball Tournament
10 | Summer Programs
11 | Yumi & Ashangbi Luikham Endowed Scholarship
12 | Where are they now? Travis Tramel, RDHAP, MA, PhD
14 | Ukrainian Children Find Hope & Healing
16 | The Global Burden of Oral Health
22 | Yearbook Roundup …

Biostratigraphic Revision Of Esthonyx (Tillidontia, Mammalia) In The Contect Of Climate Change In The Lower Eocene Of The Bighorn Basin, Wyoming, John Colter Johnson

Department of Earth and Atmospheric Sciences: Dissertations, Theses, and Student Research

Esthonyx is an early Eocene tillodont found in North America, Europe, and India. The genus was named by Edward Drinker (E. D.) Cope in 1874 based on specimens from the San Jose Formation in New Mexico. Since then, several species of Esthonyx have been described from North America alone. The best record of Esthonyx comes from the central Bighorn Basin (BHB) in Wyoming, where it appears in 220 localities in a 640 m-thick stratigraphic succession. Since the last summary of Esthonyx in the BHB, several hundred new specimens have been collected and curated at the Denver Museum of Nature and …

Multi-Case Study Of Left-Flank Boundaries Within Supercells, Peyton B. Stevenson

Department of Earth and Atmospheric Sciences: Dissertations, Theses, and Student Research

This study investigates the prevalence and significance of forward-flank convergence boundaries (FFCBs) and left-flank convergence boundaries (LFCBs) in shaping the structure and intensity of supercells, using observational data from various field projects. Unlike previous research focusing on individual cases, this study examines a diverse range of cases to provide comprehensive insights into the relationship between these boundaries and supercell characteristics such as intensity, longevity, and tornadogenesis. By analyzing high-resolution surface data, the research addresses the frequency, location, and intensity of these boundaries, and their impact on pseudo vertical vorticity, pseudo convergence, and density gradients. A total of 228 boundary identifications …

Design And Evaluation Of An Esa-Based Method Of Ensemble Subsetting For A Wofs (Warn On Forecast-Like System), Daniel J. Butler

Department of Earth and Atmospheric Sciences: Dissertations, Theses, and Student Research

Forecasting severe thunderstorm environments in the southeastern United States can be challenging due to mesoscale heterogeneities such as shortwave troughs, pre-existing airmass boundaries, cold fronts aloft, low-level jets, dry air intrusions, and mesoscale lows. To combat these challenges, ensemble sensitivity analysis (ESA) may be applied to a Warn-on-Forecast (WOF)-like ensemble to improve forecasts of severe convection through ensemble weighting and subsetting. Ensemble-based weighting and subsetting uses ensemble members that most accurately represent the thunderstorm environment in areas of mesoscale heterogeneity. This study creates and evaluates the ensemble-based weighting and subsetting in four cases of severe thunderstorm occurrence. The open parameter …

Examining Dietary Disparities And Associated Factors Among Young Children Across Diverse Racial, Ethnic And Immigrant Households In Nebraska, Naveta Bhatti

College of Education and Human Sciences: Dissertations, Theses, and Student Research

Early childhood is a crucial stage for developing eating behaviors which in turn plays a major role in determining health outcomes. Assessing children’s diet plays a crucial role in tackling the obesity epidemic. One of the ways to assess children’s dietary intake is by evaluating their dietary quality. Dietary quality refers to the overall healthfulness and nutritional value of an individual's diet, considering the combination of foods consumed over time. Research has consistently demonstrated that a high-quality diet is associated with a reduced risk of several health issues, such as all-cause mortality, cardiovascular disease incidence or mortality, cancer incidence or …

Development Of A Rule-Based Monitoring System For Autonomous Heavy Equipment Safety, Amirpooya Shirazi

Department of Construction Engineering and Management: Dissertations, Theses, and Student Research

Roadway construction work zones are constantly exposed to interactions among construction equipment, workers, and vehicles. Furthermore, ensuring safety in these areas is considered a challenging task due to the complexity of the environment. As shown in the rising trend of fatal accidents in roadway work zones, current OSHA regulations in construction safety are insufficient in effectively detecting unsafe situations and mitigating the risks. Furthermore, best practices, such as internal traffic control planning (ITCP), exhibit critical limitations requiring continuous monitoring of active work zones as well as adjustments to the site coordination plans due to the dynamic nature of work zone …

The Influence Of Student-Teacher Relationship Quality On Educational Outcomes For Students With Attention-Deficit/Hyperactivity Disorder, Cassidy Ann Spradlin

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

The purpose of this dissertation study was to examine the associations between student-teacher closeness, student-teacher conflict, and educational outcomes (i.e., academic, social, and behavioral outcomes) for students with elevated symptoms of attention-deficit/hyperactivity disorder (ADHD). Positive student-teacher relationship quality is linked to educational success and has been found to be inversely related to adverse outcomes in the general population. Previous research has examined differences in student-teacher relationship quality for students with ADHD, but the association between student-teacher relationship quality and educational outcomes is not well understood for students with ADHD. This dissertation study examined the association between student-teacher relationship quality and …

Unmanned Aerial Vehicle (Uav)-Based High-Throughput Phenotyping For Maize Improvement, Eric T. Rodene

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Modern breeding programs rely heavily on efficiently screening large numbers of genotypes for agronomic traits, such as disease resistance, drought tolerance, and yield. Identifying the genetic loci or genes associated with these traits using GWAS or functional analyses will benefit future plant breeding efforts seeking to incorporate these traits into new crop varieties, whether through conventional breeding or gene editing techniques. Unmanned aerial vehicle (UAV)-based image data has been increasingly used for this task, as it allows entire test plots to be quickly and cost-effectively phenotyped. In my research, I have developed methods to improve the accuracy of machine learning …

Performance Fatigability And Neuromuscular Responses During And After One Set Of Forearm Flexion Muscle Actions To Failure At 30% Versus 70% One-Repetition Maximum In Men And Women, Tyler Joseph Neltner

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Previous studies have examined sex differences in performance fatigability during isometric, isokinetic and controlled dynamic constant external resistance (DCER) fatiguing tasks (FT), however, whether those sex differences remain during maximal intended velocity (MIV) DCER muscle actions remains unclear. The purpose of this study was to examine the sex-related differences in the time course of fatigue, neuromuscular responses, and coactivation from the ipsilateral and contralateral limbs during MIV DCER muscle actions to failure at low versus high relative loads, as well as performance fatigability from pre- to post-testing. Twenty-seven college-aged men (n = 14) and women (n = 13) …

Exploring Producers' Willingness To Pay For Ecosystem Services: Three Essays On Soil Health, Location Preferences, And Cover Crop Adoption, Kaouter Essakkat

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

This dissertation comprises three essays: one assessing Midwest producers' willingness-to-pay (WTP) for soil health-enhancing ecosystem services (ES), another examining the impact of policy implementation locations on WTP, and a third identifying factors influencing producers' adoption of cover crops (CC).

The first essay pioneers the understanding of agricultural producers’ valuation of soil health-associated ES amid growing concerns of soil degradation due to agricultural intensification. Using a discrete choice experiment, this study assesses producers’ WTP for a policy that incentivizes ES provision, specifically improved water quality, carbon sequestration, and enhanced crop yield. Surveying producers across Iowa, Kansas, and Nebraska, our results show …

A Collection Of Short Stories, Tryphena Lizzert Yeboah

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

The short stories in this collection offer diverse and expansive realities of the human condition, particularly around the lives of women—their identities, bodies, emotions, and how they live and navigate a social order that is often constructed to dominate and undermine them. How can we complicate marginalized portrayals of women shaped by the male gaze and interrogate the patriarchal presumption of the African woman? What different approaches should be employed in capturing different aspects of her domestic and social life, how she defines and expresses autonomy, how she subverts gender norms, and her experiences of emotional and physical violence? These …

Assessment Of Foam Decontamination In Tomato Washing Process, Basim M. Alohali

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

The work of the dissertation investigated the efficacy of foam-based decontamination treatments to enhance microbial safety in Roma tomatoes, specifically targeting natural microflora and Salmonella contamination. Growing concerns over foodborne illnesses linked to fresh tomatoes and the limitations of conventional decontamination techniques, such as organic matter built-up and limited microbial reduction, are addressed. The primary objectives were to characterize the physiochemical properties of foams formed using various concentrations of Tween 20 (T20) and sodium dodecyl sulfate (SDS) with and without the addition of sodium hypochlorite (NaOCl) and peracetic acid (PAA), compare the efficacy of foam and traditional dump tank (DT) …

Estranged Temporality: How Time Tells Stories In Science Fiction, Phillip H. Howells

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

According to Darko Suvin in his influential critical treatise, Metamorphoses of Science Fiction, estrangement in Science Fiction (SF) gives authors the ability to build worlds related to but distant from our own using specific metaphors. This dissertation takes up this term and applies it to the fulcrum of time in SF as a method of creating possible futures and imaginative pasts in order to illuminate the realities of the present. The realities of the present are congruent with the material circumstances of the past, and this can be seen in the kinds of SF worlds built by members of …

Genetically Modified Bovine Milk-Derived Small Extracellular Vesicles In Drug Delivery, Alice Kah Hui Ngu

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Small extracellular vesicles (SEVs, “exosomes”) are natural nanoparticles that can be endogenously synthesized and also obtained from dietary sources, such as bovine milk SEVs (mEVs). mEVs have been extensively studied and discovered with contributive features that potentially play a role in drug delivery and other therapeutic purposes, such as diagnostic tools. Current studies have shown that mEVs have been used preclinically to carry in targeting drugs, nucleotides, biomolecules, and labels to target metabolic diseases and cancers. Extensive studies have focused on further modifying SEVs to enhance their versatility in pharmaceutical use. In this dissertation, we exhibited one of the ways …

Laser 3d Printing Of Diamond-Based Composite Materials For Thermal Management Applications, Nada Kraiem

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

With the trend towards miniaturization of electrical equipment and the constant increase in power density in semiconductor devices, efficient heat management has become a major concern for researchers. Indeed, this technological evolution imposes increasingly strict constraints in terms of thermal dissipation, necessitating innovative solutions to ensure better durability and reliability of components. In this context, the use of composite materials offering high thermal conductivity (TC) and low coefficient of thermal expansion (CTE) compared to pure metals has become essential to address overheating issues in electronic components.

The utilization of advanced materials such as diamond (D), with exceptional TC and hardness …

Advancements In Microscale Tensile Testing: A Novel Device For The High Throughput Analysis Of Two-Photon Polymerized Microfibers In Liquid, Grayson D. Minnick

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Two-photon polymerization (TPP) enables the 3D fabrication of micro- and nanostructures from biocompatible materials with high resolutions, reaching into the realm of hundreds of nanometers. Such capabilities are crucial for advancing applications in fields like mechanobiology. As microscale technologies evolve, the precise characterization of material properties becomes increasingly essential. This is especially true for TPP-printed microstructures serving as scaffolds for 3D cell culture and intended for studying the mechanics of tissues. Despite the importance, traditional micro-scale tensile testing methods typically lack scalability and fail to replicate relevant environmental conditions. This dissertation introduces a new device that is specifically designed to …