Digital Commons Network^™

Bi-Allelic Loss-Of-Function Variants In Tmem63b Cause Syndromic Surfactant Dysfunction Disorder, Sock Hoai Chan, Audra N Iness, Jill A Rosenfeld, Mir Reza Bekheirnia, Lindsay C Burrage, Matthew Hoi Kin Chau, Chaerish Eint Myet Chae Htoo, Eric C Kao, Shamika Ketkar, Wan Wan Lim, Xi Luo, Rifhan Mazlan, Elizabeth Mizerik, Kein Seong Mun, Kalyani R Patel, Lorraine Potocki, Christina K Rapp, Xavier Roca, Ana Saianda, Ignacio Iglesias-Serrano, Everlyn C Siew, Donald Yuhui Sim, David R Spielberg, Sok-Kun Tae, Jing Xian Teo, Julian Warfsmann, Fan Xia, Child-Eu Registry, Saumya S Jamuar, Ee Shien Tan, Matthias Griese, Weng Khong Lim, Meow-Keong Thong, Keren Machol

Faculty, Staff and Students Publications

Transmembrane protein 63B gene (TMEM63B) encodes a mechanosensitive ion channel expressed in alveolar type II epithelial cells, where it mediates stretch-induced surfactant secretion. While heterozygous gain-of-function variants in TMEM63B have been associated with developmental and epileptic encephalopathy, no human disorder has previously been linked to bi-allelic loss-of-function variants. Here, we report five individuals from four unrelated families with childhood interstitial lung disease and bi-allelic predicted loss-of-function variants in TMEM63B. Affected individuals presented with early-onset respiratory distress, chronic hypoxemia, and diffuse parenchymal lung abnormalities on chest imaging. One individual died in infancy, two underwent bilateral lung transplantation, and two require oxygen …

Implications Of Weather Variability On Corn Yield In The U.S., Gideon Ayettey

LSU Master's Theses

Climate variability is a major source of risk to U.S. crop production, disrupting planting schedules and threatening yields. While prior research has explored the implications of weather shocks on crop yields, this study investigates the indirect channel via which weather variability impacts corn yield through planting delays in the U.S. Previous research has shown that U.S. corn production is highly vulnerable to short-term climate variability (Hu & Buyanovsky, 2003). We use county-level data from 2015 to 2024 for the top five corn-producing states and use a 2-stage least squares method to measure the effect. However, in our specification, planting day …

Seismicity Statistics, Pore Pressure, And Fault Heterogeneity: Insights From Laboratory Stick-Slip And Friction Experiments, Navin Thapa

Electronic Theses and Dissertations Archive

The spatial, temporal, and magnitude distribution of earthquakes is governed by fault zone properties including stress state, pore pressure, gouge composition, and structural heterogeneity. Variations in the b-value of the Gutenberg–Richter frequency–magnitude distribution and in precursory fault slip behavior are thought to reflect these underlying controls, yet isolating the contribution of individual factors from natural observations remains a central challenge in earthquake physics. Here, we investigate the effects of pore pressure and compositional heterogeneity on seismicity statistics and preparatory processes through two complementary sets of laboratory experiments. In the first study, we conducted triaxial compression experiments on faulted Westerly granite …

The Role Of The Student-Teacher Relationship In The Behavioral And Academic Outcomes Of Students With Emotional And Behavioral Disorders, Samantha Warren

Graduate Teacher Education

For students with or at risk of Emotional and Behavioral Disorders (EBD), achieving success in school is challenged by a continuous cycle of behavioral and academic challenges. This literature review examined the role of student-teacher relationships in influencing both behavioral and academic outcomes for this student population. This review synthesized the findings of 15 peer-reviewed, original research studies that utilized qualitative, quantitative, and mixed-methods approaches to capture behavioral metrics and participant perspectives. The studies highlighted how distinct relational dynamics served as either a primary catalyst or a significant barrier to student improvement through day-to-day classroom interactions. Targeted praise-to-reprimand ratios and …

Oregon State Rank Assessment For Deschutes Milkvetch (Astragalus Tegetarioides), Nora Dunkirk, Gabriel Campbell, Sue Vrilakas

Institute for Natural Resources Publications

Oregon state conservation status assessment for Deschutes Milkvetch (Astragalus tegetarioides) using NatureServe methodology, 2026.

P-Value Visualizer, Manish Rami

Software

An interactive tool demonstrating what a user set p-value indicates with regards to probability.

Effect Size & Distributional Overlap Visualizer, Manish Rami

Software

An interactive tool comparing a control group and a treatment group, both with standard scores (M = 100, SD = 15). Cohen's d is expressed in standard deviation units. The three shaded regions show what each group's distribution looks like and how much they overlap. You can either use the preset buttons for effect sizes (SLP benchmarks) or the slider to change the values of Cohen's d to examine the distributions.

An Automated Electrochemistry Platform For Accelerating The Characterization Of Enzymatic Electrochemistry, Michael A. Pence, Zachary A. Nguyen, Luke G. Kays, Dylan G. Boucher, Joaquín Rodríguez-López, Shelley D. Minteer

Chemistry Faculty Research & Creative Works

Enzymatic electrochemistry harnesses the selectivity of enzymes to enable electrochemical applications spanning sensing, synthesis, and energy conversion. However, the sequential nature of electroanalytical experiments limits throughput, restricting the scale at which enzyme-electrode systems can be screened. Here we demonstrate the capabilities of an automated electrochemistry platform, eLab, to increase the throughput of enzymatic electrochemistry investigations. We used the eLab to collect over 10,000 cyclic voltammograms across a large parameter space consisting of two enzyme variants (promiscuous and wild-type glucose oxidase), 20 saccharide substrates, 21 concentrations, and four scan rates, with measurements being made all in triplicate. The expansive dataset enabled …

Oregon State Rank Assessment For Mt. Hood Bugbane (Actaea Laciniata), Nora Dunkirk

Institute for Natural Resources Publications

Oregon state conservation status assessment for Mt. Hood Bugbane (Actaea laciniata) using NatureServe methodology, 2026.

Black Entrepreneurs’ Strategies For Sustainability, Barbara Davis

Walden Dissertations and Doctoral Studies

No abstract provided.

Organizational Demands, Worker Adaptation, And The Relational Ripple Effect In Child Welfare Case Planning, Mackenzie Alexia Leach

Walden Dissertations and Doctoral Studies

No abstract provided.

Teachers’ Experiences In Teaching Foundational Reading Skills In The General Education English Language Arts Classroom In Grades 9-12, Jodi Leigh Mckenzie

Walden Dissertations and Doctoral Studies

No abstract provided.

Behavioral Intentions And Use Of Telehealth Among Afro-Caribbean Immigrants In Florida, Patsy Patricia Lindo-Wood

Walden Dissertations and Doctoral Studies

Many researchers have documented the benefits of telehealth in managing cardiovascular disease and its risk factors. However, acceptance and use of telehealth among immigrants in the United States were low compared to other users, and little is known about Afro-Caribbean immigrants and their telehealth acceptance and use. Guided by the unified theory of acceptance and use of technology, this study explored how performance expectancy, effort expectancy, social influence, and facilitating conditions shape behavioral intentions and telehealth use among Afro-Caribbean immigrants in Port St. Lucie, Florida. A generic qualitative design with a purposive sampling strategy was used to interview 17 Afro-Caribbean …

A Regression Tree Framework For Denoising And Monitoring Of Image Data, Subhasish Basak

Doctoral Theses

The proliferation of advanced image acquisition technologies has led to the routine collection of large-scale image data across numerous scientific domains. This widespread reliance on image data accentuates the imperative to develop robust and efficient imaging techniques, which are essential for supporting modern applications across various scientific and industrial domains. This dissertation focuses on the development and analysis of methods for image denoising and image monitoring, two fundamental tasks in modern image analysis. A wide array of image denoising techniques exists in the literature, each tailored to handle specific types of noise or structural characteristics. However, no single method proves …

Final Basinwide Quality Management Plan (Qmp) – 2026-2030, Revision 0, Pioneer Technical Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

2026 July 2 - Tennessee Weekly Drought Summary, Tennessee Climate Office, East Tennessee State University

Tennessee Climate Office Weekly Drought Summaries

No abstract provided.

Juvenile Justice Professionals’ Perceptions Of Prevention Programs In West Central Florida, Terry Rachelle Harmon

Walden Dissertations and Doctoral Studies

No abstract provided.

Reducing Turnover At The Frontline: Hotel Leadership Strategies, Tamica Hales

Walden Dissertations and Doctoral Studies

No abstract provided.

Managing Elderly Patients With Dementia Using Evidence-Based Non-Pharmacological Interventions In The Ed Setting, Rita Anue Cho

Walden Dissertations and Doctoral Studies

Persons with dementia frequent emergency departments (EDs), but ED staff lack understanding of cognitive impairment and evidence-base management of these symptoms, which sometimes results to unsafe encounters, aggression, agitation and assault with or without injuries. As a result, staff may resort to physical or chemical restraints to maintain safety for patients, staff, and the milieu. It is essential for staff in the ED to understand the disease process, recognize behavioral triggers, and apply evidence-based non-pharmacological interventions. The purpose of this project was to provide education to ED staff to enhance their understanding of cognitive disorders and dementia in the elderly …

Caregiving And Mental Health Among Mothers During The Covid-19 Pandemic, Makayla Elise Techentine

Walden Dissertations and Doctoral Studies

The 2019 coronavirus (COVID-19) pandemic led to reliance on family members or friends to care for the sick, resulting in a burden of informal caregiving stressors and relationship to mental health. Guided by the stress process model, this quantitative, cross-sectional study aimed to assess the relationship between caregiving stressors and the mental health of mothers of children aged 18 years or younger who were serving as informal caregivers. Secondary data from the 2020-2021 Behavioral Risk Factor Surveillance System (N = 1,772) considered the independent variables related to caregiving stressors, including hours spent caregiving, time since becoming a caregiver, personal care …

Design And Fpga Deployment Of Quantized Convolutional Spiking Neural Networks For Ecg Arrhythmia Classification, Olamilekan Banjo

Electronic Theses and Dissertations 2020 - Present

Wearable ECG monitors enable continuous cardiac surveillance, yet most remain limited to basic heart rate metrics or coarse atrial fibrillation detection, relying on cloud-based analysis that introduces latency, connectivity dependence, and battery drain. Deploying advanced multi-class arrhythmia classification directly on-device is constrained by the tight memory, power, and computational budgets of wearable hardware. This dissertation presents a Quantized Convolutional Spiking Neural Network (QCSNN) for real-time ECG arrhythmia detection on edge hardware, developed across three progressive phases.

Phase 1 introduces a separately trained two-stage QCSNN architecture — a binary classifier cascaded with a four-class classifier — trained directly via surrogate gradient …

Peer-Peer Mentoring In Undergraduate Medical Education (Ume): Scoping Review Of Us-Based Medical Schools, Sakshi Sehgal, Jordon Brinkley, Andrea Kadima, Sydney Wright, Nicole Winston Ms, Pharmd, Edd

Journal of the Georgia Public Health Association

Background: Mentorship plays a formative role in undergraduate medical education (UME) From shaping professional outcomes to developing longitudinal personal relationships, various forms of mentorship can influence student progress meaningfully, particularly for students from underrepresented or marginalized backgrounds. Though faculty-student mentorship has been readily investigated, limited knowledge exists regarding peer-peer mentorship structures, particularly within UME in the American medical education model. This scoping review sought to investigate existing peer-peer mentorship models, as well as report on the need for further mentorship within this realm in UME.

Methods: This scoping review employed Arksey and O’Malley’s framework. We conducted a systematic and comprehensive …

The Role Of Social Determinants Of Health In Hydroxyurea Adherence Among Persons With Sickle Cell Disease: A Systematic Review, Doreen O. Ugwu, Lori L. Vick, Terika Williams, Aurela Nikaj, Seyi Omeh, Benjamin Becerra Dr., Tilicia Mayo-Gamble

Journal of the Georgia Public Health Association

Objective: Georgia has one of the highest prevalences of sickle cell disease (SCD). For Georgians living with SCD, inadequate medication adherence is associated with important clinical outcomes. One important area that is understudied in SCD is the impact of social determinants of health (SDoH) on medication adherence. A foundational understanding of SDoH is needed to introduce, inform and carry out programs and interventions designed to facilitate hydroxyurea adherence through the state of Georgia.

Method: We conducted a systematic literature review to synthesize the literature on SDoH addressed in studies to improve hydroxyurea adherence in persons with SCD. SDoH were based …

Assessing Integrated Pest Management Protocols For The Invasive Aquatic Weed Giant Salvinia (Salvinia Molesta), Samantha Lee Prinsloo

LSU Doctoral Dissertations

Giant salvinia (Salvinia molesta) is free-floating aquatic fern that originates from South America. Through human introduction, giant salvinia has escaped its native range and is listed as an invasive species across multiple continents causing negative socio-economic and environmental impacts. This research aimed to expand our understanding of integrated pest management for controlling giant salvinia by combining chemical and biological control. The objectives were to assess the effects of rainfastness, carrier volume, and growth stage on herbicide efficacy, assess augmented biological control and optimal weevil release densities, assess weevil populations in the field, determine herbicide and surfactant toxicity to …

Ai-Driven Detection Of Neurodevelopmental Disorder From Emotional Speech Using A Hybrid Cnn–Bilstm–Attention Framework, Nayarah Shabir, Parveen Lehana, Sheema Khan

School of Medicine Publications

Neurodevelopmental disorders (NDDs) are associated with impairments in communication, behavior, and social interaction, making accurate diagnosis clinically challenging. Autism Spectrum Disorder (ASD), a major NDD, often exhibits atypical speech patterns characterized by altered prosody and reduced emotional expressiveness. The study proposes a hybrid dual-path framework for ASD detection from emotional speech using two strategies: PCA–GMM-based acoustic modeling and a CNN–BiLSTM–Attention architecture for spectral–temporal feature learning. The proposed framework captures probabilistic, spectral, and temporal speech characteristics for robust ASD classification. Acoustic analysis demonstrated clear separability between ASD and non-ASD speech, while the deep learning framework achieved stable and reliable performance across …

Perspective On Lessons Not Learned: From Coley’S Toxins To Microbial Drug Delivery, Guidance For Institutional Review Boards (Irbs), Brian P. Hanley, Alejandro J. Betancourt, Gustavo Gross, Wilbur (Bo) Bowne

School of Medicine Publications

The bacterial and toxin methods of cancer treatment date back 130 years. This paradigm rests on nonspecific bacterial-toxin-generated immunotherapy. This high-risk oncology research is experiencing a renaissance of methods that are among the most effective yet. Glioblastomas and other resistant cancers are the modern touchpoint, because of remission history following sepsis. Spurred by recent research deaths, we discuss protocols IRBs should consider in live bacterial or synthetic immuno-stimulatory trials. Human systemic inflammatory response syndrome immunology is unique due to non-functioning SIGLEC-13 and 17, which control excessive Toll-like receptor 4 (TLR-4) signaling. This is not a technicality like human CD8+/CD4+ T …

The Fingers-Based Occlusion Effect Triggering Methodology That Will Be Utilized For Creating Visual Imagery And Visual Patterns Utilizing A Pen Tool Where The Pen Tool Can Be Utilized To Create Visual Imagery And Visual Patterns On Physical Surfaces And On 3-Dimensional Virtual Space Areas., Punarjeewa Abeysekera

Defensive Publications Series

This paper describes a fingers-based occlusion effect triggering methodology that will be utilized for creating visual imagery and visual patterns utilizing a pen tool where the pen tool can be utilized to create visual imagery and visual patterns on physical surfaces and on 3-dimensional virtual space areas. The fingers-based occlusion effect triggering methodology will incorporate a pen tool, a built-in display that produce illumination, tracking markers and built-in camera configuration. The methodology will be required to utilize a power source that will be required to power the pen tool and its entities. And the methodology will be required to utilize …

Primitive For Finding Actionable Information In Time Series Based On Motif Locations, Michael Yeh, Yan Zheng, Junpeng Wang

Defensive Publications Series

The present disclosure relates to a system and method for finding actionable information in time series based on motif locations. The method includes an analysis computer that obtains time series data. The analysis computer generates a plurality of motifs. For each motif of the plurality of motifs, the analysis computer determines identified locations in the time series data that match the motif and determines a plurality of motif type scores based on the identified locations of the motif. The analysis computer determines a selected motif of the plurality of motifs based on the plurality of motif type scores for each …

Method, System, And Computer Program Product For Online Account Recovery, Elisa Duarte

Defensive Publications Series

Methods, systems, and computer program products are provided for online account recovery. An example method includes: receiving an account recovery request associated with a user account a user is unable to access, the account recovery request including identity data and payment device data, the payment device data obtained via short range wireless communication in response to the user arranging the payment device relative to a computing device; in response to receiving the account recovery request, authenticating the chip based on a cryptogram; in response to authenticating the chip, inputting a payment device identifier and the identity data into a model …

Optimally Scaled Low-Rank Adaptation For Efficient High-Rank Fine-Tuning, Yilang Zhang, Xiaodong Yang, Yiwei Cai

Defensive Publications Series

A method can be performed during a round of iteration during a loss function optimization process. The method can include a computer obtaining a first matrix and a second matrix. The computer can determine a selected scaling process from a first scaling process and a second scaling process. The computer can modify the first matrix and the second matrix using the selected scaling process to obtain a first modified matrix and a second modified matrix. The computer can determine a first moment and a second moment based on the first modified matrix and the second modified matrix. The computer can …