Digital Commons Network^™

Circadian Rhythms And Neuroendocrine Dysregulation In Adhd: Therapeutic Insights From Omega-3 Fatty Acids, Ayesha Zafar Iqbal, Patricia Marest Suwindi, Sunny Yin-Shan Chen, Lindsay Liang-Tien Cho, Kuan-Pin Su, Jane Pei-Chen Chang

BioMedicine

Attention-deficit hyperactivity disorder (ADHD) is a common neurodevelopmental condition often accompanied by circadian rhythm disturbances, particularly delayed sleep phase. These involve superchiasmatic nucleus (SCN) dysregulation, altered melatonin secretion, and hypothalamic–pituitary–adrenal (HPA) axis activity, which may be exacerbated by artificial light exposure. Genetic studies further implicate circadian mechanisms, linking ADHD with polymorphisms in clock genes such as PER and CLOCK.

Nutraceuticals, particularly omega-3 polyunsaturated fatty acids (n-3 PUFAs), have been proposed as modulators of circadian rhythms. N-3 PUFAs are essential for brain health and may influence melatonin synthesis and sleep–wake regulation. Preclinical and clinical findings suggest that supplementation can improve cognitive …

The Integrative Role Of Melatonin In Psychiatric Disorders: A Systematic Review Of Evidence From Circadian Biology, Lifestyle Medicine, And Psychoneuroimmunology, Ho Bao Chau Le, Kollawat Somsri, Thansita Bhunyakarnjanarat, Nattiya Hirankarn, Asada Leelahavanichkul

BioMedicine

Melatonin, a hormone produced by the pineal gland, is known for regulating circadian rhythms and has emerging therapeutic potential in psychiatric disorders. This systematic review examines evidence from clinical and preclinical studies to assess melatonin’s efficacy in the following conditions: depression, anxiety, bipolar disorder, and schizophrenia. Beyond its role in circadian regulation, melatonin exhibits antioxidative, anti-inflammatory, and immunomodulatory properties, which intersect with nutrition, lifestyle medicine, and psychoneuroimmunology (PNI).

The review finds that melatonin improves sleep quality, restores circadian balance, and modulates stress-related neuroimmune pathways. It also supports neuroplasticity and reduces oxidative stress, contributing to resilience against psychosocial and environmental stressors. …

From Rhythm To Resilience: The Interplay Of Circadian Rhythm, Melatonin, Lifestyle, Nutrition In Psychoneuroimmunology (Pni), Jane Pei-Chen Chang, Kuan-Pin Su

BioMedicine

Emerging evidence reveals that circadian rhythm, melatonin signaling, nutrition, and inflammation are intricately intertwined in shaping both mental and physical health. Circadian disruptions and lifestyle imbalances contribute to neuroinflammation, mood dysregulation, and cardiometabolic dysfunction, as seen in attention-deficit/hyperactivity disorder (ADHD), major depressive disorder (MDD), metabolic syndrome,and cardiovascular diseases. This special issue highlights interdisciplinary research that integrates circadian biology, nutrition, and psychoneuroimmunology (PNI) toward personalized and preventive psychiatry. Featured studies explore circadian and melatonin mechanisms in ADHD and MDD, the therapeutic and prophylactic potential of omega-3 polyunsaturated fatty acids (n-3 PUFAs), the neuroprotective potentical of paeoniflorin, and the role of extracellular …

Climate And Non-Genetic Effects On Goat Milk Quality And Casein Prediction Using Machine Learning, Ibrahima Mahamane Abdourhamane, Dilek Arsoy

The Thai Journal of Veterinary Medicine

Milk quality is becoming more and more crucial for farmers with the increasing use of component-based pricing systems in the sector. This study aimed to investigate the effects of climate-related and non-genetic factors on goat milk quality on the island of Northern Cyprus and to predict casein content using machine learning techniques. An analysis was performed on 21,695 goat milk samples collected between 2012 and 2018. Somatic cell count (SCC), standard plate count (SPC), and key milk components such as protein, casein, lactose, and fat were evaluated for different seasons, regions, farm sizes, and raw milk types. Five machine learning …

Pengaruh Aerobic Low Impact Exercise Terhadap Fungsi Kognitif Lansia Dengan Risiko Demensia Di Sasana Tresna Werdha Cibubur Tahun 2025, Nur Achirda, Liza Laela Abida, Kania Annisa Zahra

Jurnal Fisioterapi Terapan Indonesia

Background: Entering old age, the elderly often face various problems, one of which is impaired cognitive function. Some factors that influence the decline in cognitive abilities in the elderly include gender, education level, occupation, nutritional status, and comorbidities that can interfere with the nervous system, such as dementia and Alzheimer's disease. The problem of dementia in the elderly is an important concern that requires effective prevention and treatment. Dementia in the elderly can include several aspects, such as orientation, registration, attention and calculation, memory, and language. Physiotherapy has an important role in maintaining and improving body movement function, so that …

The Two Hungers: Food Security, Morality, And Cash Transfer Policies For Canela Apanjekra People In Indigenous Central Brazil, Bruno Nogueira Guimarães

Tipití: Journal of the Society for the Anthropology of Lowland South America

This article examines how the Canela Apanjekra (Porquinhos Indigenous Land, Maranhão, Brazil) engage with conditional cash transfer policies aimed at combating hunger—especially the Bolsa Família Program—and how these policies are interpreted through Indigenous moral economy. Drawing on long-term ethnographic research (2011–2019) and a household survey conducted in 2019, it argues that “hunger” is not a unitary condition measurable solely through individual consumption, but a relational and ecological experience shaped by obligations to share, by shame/respect (paham), and by shifting conditions of subsistence. The analysis develops the notion of “two hungers”: in the village, hunger is commonly articulated as …

The Matter Of Production And Forms Of Sharing: Transformations Of Food Economies In Lowland South America, Clarice Cohn, Diego Madi Dias, Adriana Athila

Tipití: Journal of the Society for the Anthropology of Lowland South America

This special issue of Tipití presents a critical examination of ‘food economies’ and their transformations within Indigenous communities in Lowland South America. Stemming from seminal ideas in its Anthropology that directly or indirectly discuss ‘food’ (and much of what goes along with it), this edited volume focuses on the materiality of relations as a strategic lens for understanding contemporary Indigenous lives and their transformations, according to how they are perceived by Indigenous peoples themselves and others such as health care professionals and the state. The articles explore how Indigenous foodways—from acquisition to consumption, including sharing and distribution—reveal key aspects …

Fermentative Processes Of The Agricultural Food System In The Upper Rio Negro: Ethnographic Notes On Feminine Knowledge, Intention, And Agency In The Production Of Fermented Beverages, Lorena França

Tipití: Journal of the Society for the Anthropology of Lowland South America

This article examines the fermentative processes at the core of the agricultural food system of the Upper Rio Negro, northwestern Amazon, highlighting women’s technical and social agency in the production of fermented beverages such as caxiri. Based on ethnographic fieldwork conducted among Baniwa and Tukano families between 2018 and 2019, the study explores how fermentation constitutes not merely a biochemical transformation of matter but a sociotechnical language through which women express intention, alliance, and distinction. The paper analyzes in detail two cases of caxiri preparation, showing how women’s manipulation of manioc, tubers, saliva, and utensils configures embodied knowledge transmitted …

The Influence Of Naturalness On Grocery Shoppers' Purchase Decisions In The United States, Rebecca Neusner

Honors Theses - Providence Campus

The term “natural” and naturalness labeling have increasingly been used on food packaging for a largely disinformed public who associate naturalness with qualities that are often not present in the products that display it. This survey-based study examines the influence of naturalness on the decision-making process of grocery shoppers in the United States. Survey responses were analyzed to determine the value participants place on products with naturalness indicators and to identify what other attributes they prioritize when shopping. The results indicate that participants value naturalness and price in their purchase decisions more than attributes such as brand or appearance, and …

Effectiveness Of Intradialytic Resistance Training On Muscle Mass And Strength In Patients On Hemodialysis, Sandra Vasquien, I Ketut Swarjana, A.A.A. Yuliati Darmini, I Nyoman Arya Maha Putra

Jurnal Keperawatan Indonesia

Hemodialysis (HD) patients with chronic kidney disease (CKD) lose muscle mass and strength due to protein energy wasting (PEW). The purpose of this study was to test the effectiveness of intradialytic resistance training (IRT) in increasing muscle mass and strength. It used a pre-experimental, one-group pretest-posttest design. Based on a sample size estimate using G*power software, 33 CKD patients undergoing HD at a private hospital in Bali were included. The patients were selected using purposive sampling. Muscle mass was measured using Bioelectrical Impedance Analysis (BIA), while muscle strength was measured using the Medical Research Council Muscle Scale. The Wilcoxon test …

Real-World First-Line Outcomes Of Alectinib And Brigatinib In Anaplastic Lymphoma Kinase-Positive Non-Small Cell Lung Cancer: A Nationwide South Korean Cohort Study Using The Health Insurance Review And Assessment Data, Hee Jun Kim, Eunyoung Angela Lee, Jin-Hee Park, Hyun Woo Lee

Faculty, Staff and Student Publications

Background: Lung cancer remains the leading cause of cancer-related mortality worldwide. Anaplastic lymphoma kinase (ALK)-positive non-small cell lung cancer (NSCLC) presents unique clinical challenges, including frequent central nervous system (CNS) metastases. At present, comparative real-world data on ALK inhibitors remain limited. This study aimed to compare real-world progression-free survival (PFS) and overall survival (OS) among patients with ALK-positive NSCLC treated with first-line alectinib or brigatinib using nationwide South Korean data.

Methods: This retrospective cohort study analyzed anonymized data from South Korea's Health Insurance Review and Assessment Service, covering January 2007 to December 2023. Patients diagnosed with ALK-positive NSCLC (ICD-10: C34x) …

Assessing Knowledge, Attitudes, And Consumption Of Traditional Chinese Herbal Medicine Among Filipinos Post Covid-19 Pandemic, Jane Yugioksing

Social Transformations Journal of the Global South

Traditional Chinese Medicine (TCM) in the Philippines has existed as early as the first wave of migrants but has remained confined within a prescribed settlement in the Manila district known as Parian. Over the years, TCM has existed independently as a modality of treatment to improve one’s health, mostly catering only to the Chinese in the country. At the height of the COVID-19 pandemic, the Philippines’s Food and Drug Administration (FDA) approved the use of the TCM capsule Lian Hua Qing Wen as part of the COVID-19 treatment option, which was highly patronized by the mainstream Philippine society at that …

Analysis Of Public Knowledge, Attitudes, And Practices In Food And Drug Selection In Indonesia, Tina Wikara, Sri Astuti, Sri Nurhayati, Rotua Uli Carolina, Evi Ratna Sari

Kesmas

As consumers, the public plays a vital role in ensuring the safe and appropriate use of products. This study aimed to assess awareness of food and drug safety and quality among the Indonesian population. Using a cross-sectional survey, the authors measured public awareness across three key dimensions: knowledge, attitudes, and practices. Data were collected from 20,610 respondents aged 17–65 years from 34 provinces in Indonesia. The survey approach employed a three-stage stratified sampling design. Data were collected through structured face-to-face interviews, and the results were presented as an index ranging from 0 to 100 (low to high awareness). The respondents …

Post-Release Health Insurance Utilization Among Ex-Prisoners: A Scoping Review, Icha Khaerunnisa, Megah Andriany, Luky Dwiantoro

Kesmas

The lack of health insurance coverage after prison release significantly reduces access to essential healthcare services, hindering the continuity of care during community reintegration. The evidence on studies of health insurance use following prison release is limited. This scoping review aimed to summarize research on health insurance utilization after release from prison. Literature searches were conducted across databases including ScienceDirect, PubMed, and Scopus. Relevant articles were selected through a two-stage screening process. Data were extracted from the included studies and presented in tabular and descriptive formats. The keywords used were "health insurance AND post-release" and "inmates OR prisoners." This scoping …

Workplace Policy And Associated Factors Of Minimum Acceptable Diet Practices: An Online Survey Among Working Mothers In Indonesia, Fadhila Iswi Deandra, Judhiastuty Februhartanty, Muchtaruddin Mansyur

Kesmas

Working mothers in Indonesia may influence complementary feeding practices, particularly their ability to ensure that their infants properly meet the minimum acceptable diet (MAD). In this cross-sectional study, an online survey was distributed through various online platforms where participants were recruited using convenience sampling. The questionnaire covered sociodemographic factors, workplace policies, and infant and young child feeding (IYCF) practices. Descriptive and logistic regression analyses were conducted. A total of 394 working mothers participated, of which over 90% of the respondents reported meeting minimum dietary diversity, minimum milk frequency, minimum milk feeding frequency, and MAD indicators as assessed with a standardized …

Challenges And Policies For Female Sex Workers’ Readiness To Participate In Pre-Exposure Prophylaxis Program: An Explorative Qualitative Study, Rico Januar Sitorus, Anita Rahmiwati, Diana Dewi Sartika, Elvi Sunarsih, Asri Maharani

Kesmas

The prevalence of human immunodeficiency virus is high among female sex workers (FSWs) in Indonesia, underscoring the need for integrated prevention strategies supported by strong government policies. This study aimed to investigate FSWs' willingness to participate in a pre-exposure prophylaxis (PrEP) program. This qualitative study employed semi-structured interviews with 20 participants residing in Pangkal Pinang City, Indonesia (4 stakeholders and 16 FSWs), recruited through purposive sampling. Data were collected from July to September 2024. This non-probability sampling method was adopted due to the focus on specific study objectives and a targeted population. The analysis of the interviews revealed three theme …

Participatory Implementation Science To Enhance Knowledge And Build The Capacity To Increase The Uptake And Sustainability Of Hpv Vaccination Among Girls In Nigeria, Peter Kalulu, Olufunto A Olusanya, Nkiruka Obodoechina, Maria A Afadapa, Temitope Ojo, Priscilla A Kabutey, Caven N Ngoe, Ashley Bardon, Juliet Iwelunmor, Et Al.

2020-Current year OA Pubs

BACKGROUND: Human papillomavirus (HPV) vaccination can prevent cancer in low- and middle-income countries (LMICs), but its uptake remains low, especially in Nigeria. Understanding participatory approaches can help identify local strategies to increase, build capacity for, and sustain vaccine uptake. This study evaluated the effectiveness of an innovation bootcamp in enhancing the knowledge and skills of youth implementers about HPV and cervical cancer as a strategy to increase vaccine uptake among Nigerian girls aged 9-14 years. An innovation bootcamp is an intensive training program that engages end users to build capacity and skills.

METHODS: This was a five-week hybrid bootcamp guided …

Dose-Dependent Benefits Of Dietary Yeast Cell Wall Supplementation On The Growth Performance And Stress Resilience Of The European Seabass (Dicentrarchus Labrax), Camille Houdelet, Ana Teresa Goncalves, Jorge Dias, Mark Rawling, Eric Leclercq

School of Biological and Marine Sciences

Preventive health management is central to modern aquaculture practices, within which functional feed additives are a key tool to optimising fish robustness and disease resilience. Despite being well documented, only few studies have assessed the dose–effect of graded levels of S. cerevisiae yeast cell wall (YCW) on fish performance and mucosal barrier immunity. A 9-week trial was conducted to assess the impact of graded levels of YCW on the performance and mucosal barriers of the European seabass under period: (1) non-challenge (43 days) then (2) with an applied husbandry stressors (20 days) in the form of high stocking density, low …

Gender Differences In Healthy Eating Index As Informed By The Awareness Of Diagnosis Of Metabolic Dysfunction-Associated Steatotic Liver Disease, Wei Ting Lin, Madeline Novack, Suthat Liangpunsakul, Chiung Kuei Huang, Hui Yi Lin, Po Hung Chen, Tung Sung Tseng, Peng Sheng Ting

School of Public Health Faculty Publications

Background/Objectives: Dietary quality is a driver of metabolic dysfunction-associated steatotic liver disease (MASLD). Men and women often have different levels of adherence to medical advice, but the effect of gender on adherence to dietary advice as a function of awareness of MASLD is understudied. We aim to investigate the differences in diet quality between men and women who are aware of their diagnosis of MASLD compared to their undiagnosed counterparts. Methods: We utilized the National Health and Nutrition Examination Survey 2017–2020 to identify a nationally representative sample of subjects with MASLD, 127 of whom reported a diagnosis of MASLD (diagnosed …

From Insight To Impact: Cns Consults In The Cvicu, Sarah Beldin, Kristina Boudreau

Biennial Convention (CONV)

Clinical Nurse Specialists (CNSs) are frequently consulted for their expertise, but formalizing this process via the electronic medical record (EMR) provides new opportunities for direct correlation of utilization of the CNS as a patient intervention to outcomes improvement. This project established a structured CNS consult process in the Cardiovascular Intensive Care Unit (CVICU), enabling multidisciplinary team members to order CNS consults tied to various concerns and access detailed post-consult notes in real time.

This project aimed to formalize CNS consults in the CVICU using EMR integration to enhance interdisciplinary collaboration and improve patient outcomes. By enabling team members to request …

Seeking Zero: Development Of A System-Wide Clabsi Prevention Policy, Daniel Martin, Cindy Beckett, Kady Martini, Todd Tussing, Emma Kociba

Biennial Convention (CONV)

In September 2024, at a 17-hospital Midwest United States healthcare system, quality assurance and nursing staff identified that a standardized system-wide central line-associated bloodstream infection (CLABSI) prevention and maintenance policy did not exist. This revelation occurred after an investigation noted an increase in CLABSIs, an issue compounded as each of the organization's hospitals were without system-level guidance on the prevention of CLABSIs. Therefore, using the PICOT question “In high-risk patients (P), how do system-wide best practices/strategies (I) compared to current practice (C) affect CLABSI (O)?, a systematic review of the published literature was conducted using CINAHL, PubMed, Scopus, and Embase …

Red Midge Larvae Are An Invertebrate Alternative Diet To Beef Liver For Planarian Husbandry, Jonah Pacis , '25, Danielle Ireland, Evangeline Coffinas, Jerome Sheehan, Kate Sun , '27, Eva-Maria S. Collins

Biology Faculty Works

Freshwater planarians are an emerging model for toxicology and neuroscience because of their amenability to rapid behavioral screening and remarkable ability to regenerate a cephalized nervous system. As invertebrates, planarians can help reduce the use of vertebrates in research; however, laboratories typically maintain planarians on diets of homogenized organic beef or chicken liver, raising ethical concerns with feeding a vertebrate diet. Organic liver is difficult to obtain, and preparation methods vary, introducing intra- and interlaboratory variability. Here, we show that Dugesia japonica planarians can be maintained for over a year on commercially available red midge larvae (RML), a natural prey …

The 23rd International Medical, Pharmaceutical, Cosmeceutical And Health Science Symposium (Impachs), Sultan Qaboos University

Sultan Qaboos University Medical Journal

No abstract provided.

Addressing The Burden Of Prematurity And Its Prevention In Developing Countries: Is It Time To Act Now?, Mahaveer Singh Lakra, Amar Taksande, Revat J. Meshram, Ashwini Lakra, Amit Kumar, Deepak Gandhi, Roshan Prasad, Mayur Wanjari

Chulalongkorn Medical Journal

Around 3.5 million preterm births occur in India annually, accounting for about 25% of all preterm births worldwide. Prematurity poses a significant burden world-wide but leaves a special impact on the families and health systems of low-socioeconomic countries where easy and universal access to adequate health services is compromised. Premature birth imposes a significant risk of neonatal death among all under-fives due to organ immaturity, sepsis, and respiratory distress syndrome. Efforts to address prematurity on a global scale involve a multifaceted approach, including improving access to quality prenatal care, enhancing neonatal care services, and implementing public health interventions to reduce …

Unleash The Potential - Our Vision For East Africa

Vision and mission statements

No abstract provided.

Biochar Derived From Different Sources Ameliorates The Phytochemical And Physiological Characteristics Of Foxtail Millet (Setaria Italica) Under Water Stress, Mohammad Keshavarz, Ehsan Bijanzadeh, Hamid Reza Boostani

Turkish Journal of Botany

Organic material, such as biochar, can improve soil fertility and crop yield under water stress. A pot experiment was conducted to consider the effects of biochar on the pigment content, enzyme activity, physiological characteristics, and nutrient uptake of foxtail millet under water stress. Plants were tested under normal, mild, and severe irrigation regimes (100%, 75%, and 50% field capacity, respectively) using different biochar sources (licorice root biochar (LRB), cow manure biochar (CMB), cotton residue biochar (CRB), and municipal waste biochar (MWB)) and a control without fertilizer. Under severe water stress, the chlorophyll a content and total chlorophyll increased by 137.3% …

Protective Role Of Salicylic Acid Against Abiotic Stresses In Horticultural Crops: A Review, Faisal Hayat, Xiaoyun Zhang, Mohammed Alyafei, Fareeha Shireen, Ummara Khan, Sumeera Asghar, Sezai̇ Erci̇şli̇, Karthishwaran Kandhan, Mohamed S. Sheteiwy, Yali Zhang, Xiaoyan Lu

Turkish Journal of Botany

Environmental stressors such as drought, floods, salinity, extreme temperatures, and heavy metal toxicity are major threats to horticultural plants because they disrupt plant physiological mechanisms, leading to reduced yield and quality. Salicylic acid (SA) is a plant hormone that regulates various physiological and biochemical functions in plants. Moreover, it regulates hormonal balance, enhances the absorption of essential nutrients, promotes photosynthesis and the production of antistress compounds, and improves stress resistance. This comprehensive review explains several physiological and biochemical activities that are affected by SA under stressful conditions, such as stomatal regulation, antioxidant defense systems, osmotic adjustment and gene expression regulation. …

Tannin Supplementation Alters Foraging Behavior And Spatial Distribution In Beef Cattle, Bashiri Iddy Muzzo, R. Douglas Ramsey, Kelvyn Bladen, Juan J. Villalba

Wildland Resources Student Research

Beef production on chemically uniform grass monocultures can limit nutrient synchrony and contribute to uneven pasture use. We evaluated whether supplementing tannins with bioactive plant secondary compounds improves foraging dynamics and landscape use by beef cattle grazing a meadow bromegrass monoculture in ways aligned with rangeland sustainability. Twenty-four Angus cow–calf pairs were allocated to six 3.6-ha paddocks (four pairs/paddock), randomly assigned to Control (Ctrl; n = 3) or Tannin treatment (TT; n = 3). Animals received 1 kg/cow/day of DDGs, with TT receiving an added 0.4% tannins (2:1 condensed:hydrolyzable). Grazing occurred during four 15-day periods (July– September) across two years. …

Dietary Fiber Modulates Gut Microbiota And Lipid Metabolism Ameliorating Alzheimer's Pathology In 5xfad Mice, Yuhai Zhao, Christopher M. Taylor, Walter J. Lukiw, Nicolas G. Bazan

School of Graduate Studies Faculty Publications

The gut-brain axis plays a critical role in maintaining neuronal integrity and influencing the progression of Alzheimer's disease (AD). Here, we investigated how commonly consumed dietary fibers modulate gut microbiota, lipid metabolism, and AD pathology in 5xFAD mice. Male mice were fed either fiber-free (FF) or fiber-plus (FP; 1% cellulose, 2% pectin, 2% inulin) diets for five months, followed by integrated analyses of gut microbiota (16 S rRNA sequencing), fecal lipid metabolites (LC-MS/MS), and neuropathological and behavioral outcomes. FP diets markedly altered microbial composition, characterized by increases in Muribaculaceae, Ileibacterium, and Lachnospiraceae NK4A136 group and reductions in Faecalibaculum and Coriobacteriaceae …

Nickel Toxicity To Safflower Seed Germination And Seedling Morphoanatomy, Uğurcan Baran, Sude Tanik, Mert Can Vardar, Güray Ülger, Ahmet Aksoy

Turkish Journal of Botany

The safflowers (Carthamus tinctorius L. cv Olas) grown hydroponically under nickel (Ni) stress were examined in this study. T he effects of 0, 0.75, 1, 3, 5, 10, and 15 mM Ni on seed germination rate, protein, and pigment content of germinating seeds were investigated. Also, the toxicity of 0.75 mM Ni on plant growth, malondialdehyde (MDA) amount, and anatomy of 21-day-old safflower seedlings were studied. Ni adversely affected the germination rate, radicle length, protein, and pigment content of safflower seeds, particularly when higher than 3 mM. It also negatively affected the biomass production, plant length, leaf number, and MDA …