Digital Commons Network^™

Health-Related Quality Of Life In Pediatric Acute Recurrent Or Chronic Pancreatitis: Association With Biopsychosocial Risk Factors, See Wan Tham, Fuchenchu Wang, Cheryl E Gariepy, Gretchen A Cress, Maisam A Abu-El-Haija, Melena D Bellin, Kate M Ellery, Douglas S Fishman, Tanja Gonska, Melvin B Heyman, Tom K Lin, Asim Maqbool, Brian A Mcferron, Veronique D Morinville, Jaimie D Nathan, Chee Y Ooi, Emily R Perito, Sarah Jane Schwarzenberg, Zachary M Sellers, Uzma Shah, David M Troendle, Michael Wilschanski, Yuhua Zheng, Ying Yuan, Mark E Lowe, Aliye Uc, Tonya M Palermo, International Study Group Of Pediatric Pancreatitis: In Search For A Cure (Insppire) And Consortium For The Study Of Chronic Pancreatitis, Diabetes And Pancreatic Cancer (Cpdpc)

Faculty, Staff and Students Publications

OBJECTIVES: Abdominal pain, emergency department visits, and hospitalizations impact lives of children with acute recurrent pancreatitis (ARP) and chronic pancreatitis (CP). Data on health-related quality of life (HRQOL) in this population, however, remains limited. We aimed to evaluate HRQOL in children with ARP or CP; and test biopsychosocial risk factors associated with low HRQOL.

METHODS: Data were acquired from the INternational Study Group of Pediatric Pancreatitis: In search for a cuRE registry. Baseline demographic and clinical questionnaires, the Child Health Questionnaire (measures HRQOL) and Child Behavior Checklist (measures emotional and behavioral functioning) were completed at enrollment.

RESULTS: The sample included …

Comparative Effects Of Eccentric Overload Training On Muscle Function Measures When Combined With Aquatic Plyometric Training, Cassidy Weeks

All Graduate Plan B and other Reports, Spring 1920 to Spring 2023

Although there is a growing body of knowledge on eccentric resistance training and aquatic plyometric training on muscle function measures alone, no research to date has investigated the effects of a mixed training model. Aquatic plyometrics and overload eccentric training are two different training models which could work synergistically because the shortcomings of one model are the virtues of the other (i.e., plyometrics are not as effective at producing large muscle size and strength gains and eccentric-only training largely lacks the functional SSC component). The purpose of this study was to examine and compare the effects of a combined eccentric …

Relationship Of Eccentric Strength And Forward Perturbation Restabilization After Foot Contact, Leandra K. Ashworth

All Graduate Plan B and other Reports, Spring 1920 to Spring 2023

Background: Forward falls are the most common fall direction and pose safety concerns for adults. To prevent forward falls, compensatory steps, and change-in-support reactions (e.g., foot contact) are critical for restabilizing center of mass after unpredictable, balance disturbances. Multi-joint, lower limb eccentric and isometric strength may provide additional insight on foot contact responses after a forward, temporally unpredictable perturbation. Multi-joint, eccentric muscular contractions have been found to result in significant neuromuscular adaptations (e.g., hypertrophy and muscular strength) and have higher retention capabilities than concentric contractions. Due to the importance of muscular strength in balance recovery, eccentric muscular strength could provide …

Circadian Regulation Of Gene Expression And Metabolism In The Liver, Dongyin Guan, Mitchell A Lazar

Faculty, Staff and Students Publications

Circadian rhythms are approximately 24-hour cycles of variation in physiological processes, gene expression, and behavior. They result from the interplay of internal biological clocks with daily environmental rhythms, including light/dark and feeding/fasting. Note that 24-hour rhythms of liver metabolic processes have been known for almost 100 years. Modern studies reveal that, like metabolism, hepatic gene expression is highly rhythmic. Genetic or environmental changes can disrupt the circadian rhythms of the liver, leading to metabolic disorders and hepatocellular carcinoma. In this review, we summarize the current understanding of mechanisms regulating rhythmic gene expression in the liver, highlighting the roles of transcription …

Heightened Levels Of Plasma Growth Differentiation Factor 15 In Men Living With Hiv, Neeti Agarwal, Claudia E Ramirez Bustamante, Huaizhu Wu, Reina Armamento-Villareal, Jordan E Lake, Ashok Balasubramanyam, Sean M Hartig

Faculty, Staff and Students Publications

Plasma biomarkers that reflect energy balance disorders in people living with HIV (PLWH) remain limited. Growth differentiation factor 15 (GDF15) abundance in plasma of mice and humans induces negative energy balance but also becomes highly elevated in obesity and other metabolic diseases. We sought to compare plasma GDF15 levels in PLWH and HIV-negative persons and mouse models expressing the HIV accessory protein Vpr (that recapitulate HIV-associated metabolic disorders) and determine their relationship to metabolic parameters. We measured liver Gdf15 mRNA levels and plasma GDF15 levels in male Vpr mice and littermate controls. In parallel, we analyzed plasma GDF15 levels in …

Engagement Of Families In The Care Of Hospitalized Pediatric Patients: A Scoping Review, Teresa Jerofke-Owen, Natalie S. Mcandrew, Karen Gralton, Joan P. Totka, Marianne E. Weiss, Alissa V. Fial, Kathleen J. Sawin

College of Nursing Faculty Research and Publications

This scoping review was conducted to examine the range, nature, and extent of the published family engagement literature specific to the pediatric acute care setting to highlight future research and practice development opportunities. Included studies (N = 247) revealed global relevance. Engagement strategies ranged from more passive such as allowing/encouraging families to be present at the bedside to more active strategies aimed at promoting mutual and reciprocal nurse–patient interactions. Family engagement is distinguished by a mutually beneficial partnership of families with health care team members and care organizations. Future research in the area of family engagement in pediatric nursing …

Present Limitations And Future Projections: Food Insecurity, Housing Insecurity And Optimism Among College Students, Amber Obermaier

Graduate Theses and Dissertations

Within the last decade, research has identified wide-ranging disparities in access to basic needs among university students. These differences, such as a lack of adequate food and housing during university, provide a negative environmental experience with potential to limit one’s optimism or hope for the future. This research explores how basic needs insecurity and social vulnerabilities among college students are related to subjective assessments of their prospects for the future. The present study utilizes survey data from a random sample of college students (n=300) enrolled at an urban university in the Midwest region of the United States of America. Logistic …

Informing The Parent Component Of An Acceptance-Based Behavioral Weight Loss Treatment Program Tailored For Hispanic Adolescents In The El Paso Region, Patrick Vaughn Hopkins

Open Access Theses & Dissertations

ABSTRACT

Regarding the clinical efficacy of adolescent weight loss interventions, no agreed-upon definitions or standards for weight loss success exist among pediatric populations, nor do they exist for weight regain or weight maintenance. There are currently no safe, efficacious, long-term treatment options for Hispanic adolescents with overweight or obesity (OW/OB). The purpose of this study was to gather data to inform development of an acceptance-based behavior therapy (ABT) intervention for adolescents with OW/OB in the Paso del Norte region. The primary goal of this research study was to inform the parent component of this adapted intervention. A secondary goal was …

The Experience Of Immigration And Aging On The Health Of Older Adults In The El Paso, Texas, Border Region, Sonia Lizet Ramos

Open Access Theses & Dissertations

Healthcare access continues to be a problem for immigrant populations in the United States, especially for Latino immigrants at the US-Mexico border. There is limited social research examining the experience of access to health care of older adult Latino immigrants during their life course in the U.S. In U.S.-Mexico border communities, documented and undocumented residents face unique experiences when accessing health care. This thesis focuses on understanding the intersectionality of the immigration process and health care access of older adult Latino immigrants on the U.S.- Mexico. Using qualitative data collected from participants living in the County of El Paso, Texas, …

Inflammaging: Inflammatory Biomarkers Associated With Nutrition, Metabolism And Muscle Tissue Oxygenation Relative To Sarcopenic Status In Older Adults, Marni Elise Shoemaker

Open Access Theses & Dissertations

The purpose of this study is to examine if we can differentiate inflammaging between sarcopenic and non-sarcopenic older adults by exploring if there are differences between biomarkers of inflammation and nutritional status in older adults with distinct differences in skeletal muscle mass, strength, and function, metabolic flexibility, and muscle tissue oxygenation. Twenty-one non-sarcopenic (mean±standard deviation, age = 73.1±6.2 yrs, n=5 males, n=5 females) and sarcopenic (age = 81.2±10.5 yrs, n=6 males, n=5 females) were categorized based on muscle mass and strength criteria according to the European Working Group on Sarcopenia in Older People. Body composition, handgrip and leg extension strength, …

Implications Of Metal Coordination In Damage And Recognition Of Nucleic Acids And Lipid Bilayers, Ana Dreab

Chemistry & Biochemistry Theses & Dissertations

Metal ions have a myriad of biological functions from structural stability to enzymatic (de)activation and metabolic electron transfer. Redox-active metals also mediate the formation of reactive oxygen species which may either cause oxidative damage or protect cellular components. Computational modeling is used here to investigate the role of (1) metal-ion binding to antimicrobial peptides, (2) metal-ion removal and disulfide formation on zinc finger (ZF) proteins, and (3) coordination of thiones/selones for the prevention of metal-mediated redox damage.

Piscidins, natural-occurring antimicrobial peptides, efficiently kill bacteria by targeting their membranes. Their efficacy is enhanced in vitro by metal-binding and the presence of …

Temporal Dynamics And Seed Dispersal In Plant-Frugivore Communities Of The Dominican Republic, Spencer Christian Schubert

Biological Sciences Theses & Dissertations

Plant-animal mutualisms are a foundational component of biodiversity in terrestrial ecosystems. Most tropical forest plants have adapted to produce fleshy fruits to attract frugivorous animals to disperse seeds. Interaction patterns among plant taxa and their seed dispersers are driven by a complex suite of factors involving their evolutionary history and environmental context, and the structure of these mutualistic networks are theoretically tied to their ecological function. I carried out a series of field studies to investigate the temporal dynamics of mutualistic interactions of plant and avian frugivore communities in the central Dominican Republic and how their characteristics affect seed dispersal …

Strategies To Prevent Central Line-Associated Bloodstream Infections In Acute-Care Hospitals: 2022 Update, Niccolò Buetti, Jonas Marschall, Marci Drees, Mohamad G Fakih, Lynn Hadaway, Lisa L Maragakis, Elizabeth Monsees, Shannon Novosad, Naomi P O'Grady, Mark E Rupp, Joshua Wolf, Deborah Yokoe, Leonard A Mermel

2020-Current year OA Pubs

No abstract provided.

The Heritage Family Study: A Review Of The Effects Of Exercise Training On Cardiometabolic Health, With Insights Into Molecular Transducers, Mark A Sarzynski, Treva K Rice, D C Rao, Et Al

2020-Current year OA Pubs

The aim of the HERITAGE Family Study was to investigate individual differences in response to a standardized endurance exercise program, the role of familial aggregation, and the genetics of response levels of cardiorespiratory fitness and cardiovascular disease and diabetes risk factors. Here we summarize the findings and their potential implications for cardiometabolic health and cardiorespiratory fitness. It begins with overviews of background and planning, recruitment, testing and exercise program protocol, quality control measures, and other relevant organizational issues. A summary of findings is then provided on cardiorespiratory fitness, exercise hemodynamics, insulin and glucose metabolism, lipid and lipoprotein profiles, adiposity and …

Evaluating Plant Uptake Of 4,4'-Methylenedianiline, Jeff Wight

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

4,4’-Methylenedianiline (MDA) is an important industrial chemical used primarily in the production of polyurethane. It is toxic and a suspected human carcinogen. Polyurethane is used in a wide variety of applications such as furniture cushioning, coatings, adhesives, sealants, and elastomers. Polyurethane in soil may degrade and release MDA. This is concerning due to some models predicting a high potential for MDA to be taken up by plants and stored in edible tissue, creating a possible route of exposure for humans and animals. In this project, the potential for MDA to be take up by plants was investigated in order to …

Effects Of Providing Novel Feedstuffs To Livestock On Production And Skeletal Muscle Growth, Laura A. Motsinger

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

As the population increases and available land for food production decreases, it is necessary for livestock producers to continually work towards increasing livestock production efficiency. In livestock operations, feed accounts for the majority of input costs associated with raising livestock. As such, it is necessary to improve growth and production of livestock animals, while also optimizing feed utilization. Different feedstuffs can be included in the diet of livestock animals to maximize growth and production. However, the effects of some of these novel feedstuffs on growth and production of livestock animals has not been elucidated. As such, we investigated the effects …

Nutrient Uptake And Water Quality In Great Salt Lake Wetland Impoundments, Rachel L. Buck

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The Great Salt Lake (GSL) is the largest inland body of water on the Pacific flyway, a major pathway for migratory birds in the Americas that extends from Alaska to Patagonia. The lake is surrounded by approximately 360,000 acres of wetlands, providing critical food, shelter, cover, nesting areas, and protection to between 4–6 million birds that visit each year. Impounded wetlands were created as part of the GSL ecosystem to support waterfowl habitat. These large, shallow, submergent wetlands are diked to control water levels to sustain aquatic plants which are an important food source. Besides providing critical habitat, these impoundments …

Global Change Effects On Carbon Cycling In Terrestrial Ecosystems, Guopeng Liang

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Since terrestrial ecosystems store approximately 3 times more carbon (C) than the atmosphere, they have a significant effect on the atmospheric CO₂ concentration. Although many studies have been conducted to determine global change effects on C cycling in terrestrial ecosystems, the underlying mechanisms remain uncertain. To address this knowledge gap, I utilized meta-analysis, laboratory experiments, and soil microbial community analysis.

In chapter 2, I conducted a meta-analysis to examine whether effects of long-term N addition on plant productivity can shift over time. I found that 44% of studies showed a marked trend (increase or decrease) in the strength of …

An Exploration Of Parent Management Training Programs And Their Cultural Relevance, Maria De La Caridad Alvarez

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Behavioral parent training is a research-supported treatment for improving child behavior and increasing parenting skills. Despite many programs sharing a theoretical foundation and common elements, there is great variety in terms of treatment targets, populations served, treatment length, delivery setting, and expected outcomes. The purpose of this research was to first systematically organize and categorize relevant program information for the most frequently referenced Parent Management Training (PMT) programs. To this end, 19 programs were identified for review. We summarized each program and their available research evidence which ranged from 1 to 72 studies. The findings from this first project informed …

Role Of Mitochondria In Postmortem Proteolysis And Meat Tenderness, David Son Dang

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Among all eating quality characteristics in beef, tenderness is regarded as one of the most important traits. Previous research indicates that consumers are willing to pay a premium for beef guaranteed to be tender. Yet, tenderness is difficult to control and predict as it is influenced by a multitude of factors. Among these factors, meat aging has been shown to be a strong determinant of tenderness. Meat aging describes a process in which muscle tissue is broken down by other proteins within the muscle, resulting in a more tender product after cooking. Two well-recognized proteins that participate in the breakdown …

Greater Sage-Grouse Brood Responses To Livestock Grazing In Sagebrush Rangelands, Hailey Peatross Wayment

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The distribution and abundance of the greater sage-grouse (Centrocercus urophasianus; sage-grouse) have declined in the last 60 years. Range contractions and population declines have been attributed to loss and fragmentation of their sagebrush (Artemisia spp.) habitats. Grazing by livestock remains the predominant anthropogenic land-use across sagebrush ecosystems in North America, occurring on 87% of remaining sage-grouse habitat. Most of the peer-reviewed literature reports the potential for negative impacts of sagebrush reduction treatments, to increase livestock forage, on sage-grouse habitat. However, few studies have linked livestock grazing at the landscape level to vital rates (e.g., nest initiation rates, …

Impact Of Ph And Palmitic Acid On Ruminal Fermentation And Microbial Community Composition, Lexie Padilla

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The objective of this study was to evaluate the effects of dietary palmitic acid and pH on rumen fermentation, fiber digestibility, and bacterial community composition. The two factors in the experiment were palmitic acid treatment and pH treatment. Palmitic acid treatments included a control diet compared to a diet containing 1.5% palmitic acid. pH treatments included normal pH (6.6 to 7.0) compared to low pH (6.0 to 6.4). Rumen fluid from a cow was added to artificial rumens to study the effects of the two treatments relative to fermentation and changes within the microbial community. Results of the study showed …

Bullied Because Of Their Teeth: Evidence From A Longitudinal Study On The Impact Of Oral Health On Bullying Victimization Among Australian Indigenous Children, Md Irteja Islam, Verity Chadwick, Tuguy Esgin, Alexandra Martiniuk

Research outputs 2022 to 2026

Making life better for Indigenous peoples is a global priority. Although bullying and oral health have always been a topic of concern, there is limited information regarding the impact of this problem on the general population, with no evidence in this regard among the Australian Indigenous population. Thus, we aimed to quantify the relationship between bullying victimization and oral health problems by remoteness among 766 Australian Indigenous children aged between 10–15-years using data from the LSIC study. Bivariate and multilevel mixed-effect logistic regression analyses were employed. Findings indicated children self-reported bullying more than parents reported their children were being bullied …

Dietary Iron And The Elite Dancer, Caitlin Attwell, Cory Dugan, Alannah K. A. Mckay, Joanna Nicholas, Luke Hopper, Peter Peeling

Research outputs 2022 to 2026

Dancers are an athlete population at high risk of developing iron deficiency (ID). The aesthetic nature of the discipline means dancers potentially utilise dietary restriction to meet physique goals. In combination with high training demands, this means dancers are susceptible to problems related to low energy availability (LEA), which impacts nutrient intake. In the presence of LEA, ID is common because of a reduced mineral content within the low energy diet. Left untreated, ID becomes an issue that results in fatigue, reduced aerobic work capacity, and ultimately, iron deficient anaemia (IDA). Such progression can be detrimental to a dancer’s capacity …

Characterization Of Retinal Drusen In Subjects At High Genetic Risk Of Developing Sporadic Alzheimer’S Disease: An Exploratory Analysis, Inés López-Cuenca, Elena Salobrar-García, Inés Gil-Salgado, Lidia Sánchez-Puebla, Lorena Elvira-Hurtado, José A. Fernández-Albarral, Federico Ramírez-Toraño, Ana Barabash, Jaisalmer De Frutos-Lucas, Juan J. Salazar, José M. Ramírez, Ana I. Ramírez, Rosa De Hoz

Research outputs 2022 to 2026

Having a family history (FH+) of Alzheimer’s disease (AD) and being a carrier of at least one ε4 allele of the ApoE gene are two of the main risk factors for the development of AD. AD and age-related macular degeneration (AMD) share one of the main risk factors, such as age, and characteristics including the presence of deposits (Aβ plaques in AD and drusen in AMD); however, the role of apolipoprotein E isoforms in both pathologies is controversial. We analyzed and characterized retinal drusen by optical coherence tomography (OCT) in subjects, classifying them by their AD FH (FH-or FH+) and …

Understanding The Fate And Transport Of Per- And Polyfluoroalkyl Substances In Wastewater Systems: A New England Perspective, Sydney Kathleen Adams

Master's Theses and Capstones

This thesis explores the story of per- and polyfluoroalkyl substances (PFAS) in New England wastewater systems. PFAS compounds, known for their environmental persistence, toxic nature, and heavy integration into our daily lives, has recently become an infamous topic in environmental engineering due to the discovery of contaminated agricultural lands, water resources, and food systems. In response to these daunting discoveries, regulators have begun looking to reduce point source pollution of PFAS, including that of wastewater systems and facilities. As conduits of PFAS, wastewater systems funnel PFAS from industrial, commercial, and residential sources and emit them into the environment via aqueous …

Social-Emotional Learning: A Literature Review, Stella M. Westhoven

Electronic Theses and Dissertations

ABSTRACT

Social-emotional learning targets the development of positive interpersonal relationships, empathy, emotional regulation, healthy identities, personal/collective goal orientation, and responsibility in the decision-making process (CASEL Organization, 2021). Schools, however, have the main objective of ensuring that academic measures are met. Linking social-emotional learning and skills to the school system’s principal goal, academic results, can facilitate the greater implementation of such programs within the school setting. This systematic literature review examined the relationship between social-emotional learning programs in schools and academic outcomes, such as grades, test scores, or grade point averages. Secondly, it explored the relationship between students’ social-emotional skills and …

Macronutrient Availability Shapes Host Response To Infection And Feeding Behavior, Weston Gerald Perrine

Graduate Theses and Dissertations

Macronutrients in the diet are vital to the physiological processes necessary for an organism to effectively clear a pathogen. Diet can be important to a host’s susceptibility to infection and severity of pathology, though results can vary across host-pathogen systems (Sen et al. 2016). Manipulating the ratio of specific macronutrients in the diet is an effective method to begin understanding how individual macronutrients, rather than food types, have on immune responses. Using an avian host-pathogen system, I explored the effects of dietary macronutrient composition, specifically lipid and protein content, on disease pathology and behavior of canaries (Serinus canaria) infected with …

The Impact Of Dietary Protein Supplementation As Part Of A Time Restricted Feeding Eating Pattern On Sleep, Mood, And Body Composition In Adults With Overweight Or Obesity, Rebecca L. Bowie

Graduate Theses and Dissertations

Obesity in the United States continues to increase, and effective, long-term weight loss strategies are limited. Time restricted feeding (TRF) is a dietary intervention that has potential to serve as an effective long-term weight loss strategy, however more data is needed to establish the effectiveness of a TRF eating pattern on obesity and its related health outcomes. To our knowledge, manipulation of macronutrient composition during TRF intervention and the effect of TRF on sleep and mood have not been studied. Therefore, the objective of this study was to determine the effect of protein supplementation during TRF on mood, sleep, and …

A Mixed Methods Approach To Context Specific Curriculum Design For Very Small And Small Strawberry Growers In The Southeastern United States, Thomas A. Yeargin

Graduate Theses and Dissertations

Outbreaks of foodborne illness due to fresh produce are a continued threat to both the publichealth and the economy in the United States. Though there are many factors which influence the perpetuation of foodborne pathogens, the inability of the food industry to curtail this issue indicates systemic failure of interventions aimed at improving food safety practices. In this dissertation, we detail the efforts made over the past few decades to provide training to food producers and food handlers as well as recommendations that have been made for improvement based on these studies. By borrowing from more advanced fields of study …